1201: Benjamin Bikman | Insulin Resistance Is Killing Half of America

Summary

The Jordan Harbinger Show, Ep. 1201: "Benjamin Bikman | Insulin Resistance Is Killing Half of America"
Release Date: August 26, 2025

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Episode Overview

This episode features Dr. Benjamin Bikman, PhD in bioenergetics, leading researcher in metabolic health, and author of "Why We Get Sick." Jordan and Dr. Bikman deliver a compelling, accessible, and sometimes startling deep-dive into the dangers of insulin resistance—a hidden health epidemic that now affects nearly half of U.S. adults. The discussion spans misunderstandings around metabolism, how insulin resistance develops and wreaks havoc, why it can strike the thin as well as the overweight, new insights on GLP-1 medications like Ozempic, and practical, actionable changes listeners can make to radically improve their health.

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Key Discussion Points and Insights

1. What is Bioenergetics?

• Defining "Bioenergetics":
  Dr. Bikman clarifies that bioenergetics is a real, scientific discipline focusing on how mitochondria produce energy at a cellular level, blending biochemistry and physiology.
  • "Bioenergetics is a bit more of a heavy emphasis on the mitochondria, which is the powerhouse, the energy producing part of the cell." (03:57, Bikman)

2. The Real Metabolic Epidemic

• Not Just Obesity and Sugar:
  It's not just eating too much sugar or being overweight—it's about chronically elevated insulin. Dr. Bikman argues that nearly all modern cardiometabolic diseases have a root in persistent, unrecognized insulin resistance.
  • "As much as we have a glucose centric paradigm of metabolic health...we're missing the more important marker." (05:19, Bikman)
• Metabolic Syndrome Explained:
  The hosts demystify "metabolic health," emphasizing it's not about "speeding up" metabolism with broccoli or superfoods, but the complex chemistry of how our bodies handle nutrients and build or break down molecules.
  • "Metabolism is the sum of all chemical reactions happening in a cell at any moment." (07:05, Bikman)

3. Insulin Resistance: Symptoms and Significance

• What is Insulin Resistance? Dr. Bikman defines it in two parts:
  • (1) Some cells become less responsive to insulin
  • (2) The body produces more insulin (hyperinsulinemia)
• Downstream Damage:
  Most doctors treat symptoms (e.g., high blood pressure, erectile dysfunction) with drugs, not realizing they’re all "branches of the same diseased tree"—insulin resistance.
  • "We're never actually just looking at the whole tree and say, why don't we just chop the whole thing down?” (12:24, Bikman)

4. Thin People at Risk: The Role of Genetics & Fat Distribution

• Not Just a "Fat Person's Disease":
  Some ethnicities, especially East/South Asians and Hispanics, have lower thresholds for fat storage and develop insulin resistance at much lower levels of body fat compared to Caucasians.
  • "It's the size of the fat cell that matters and not the mass of fat." (18:24, Bikman)
• Visceral vs. Subcutaneous Fat:
  Where you store fat has a greater health impact than how much you store. Visceral (organ-surrounding) fat is particularly harmful.

5. How Insulin Resistance Develops

• Three Major Drivers:
  1. Stress (adrenaline/cortisol)
  2. Inflammation (less controllable)
  3. Most important: Chronic high insulin from frequent spikes—almost entirely from constant consumption of refined starches and sugars.
  • "A fundamental feature of biology is that too much of something will generally result in a resistance to that something." (24:31, Bikman)
• Modern Eating Habits:
  The average person is in a "state of elevated insulin" all day—breakfast, snacks, lunch, and so on never allow insulin to drop.

6. Detecting Insulin Resistance — Beyond Standard Bloodwork

• Blood Markers:
  • Fasting Insulin: Should be below ~6 µIU/mL, but rarely tested.
  • Triglyceride/HDL Ratio: A value under 1.5 is a strong indicator of insulin sensitivity. (33:57)
• Visual Cues:
  • Skin changes (acanthosis nigricans: dark, thick, creased neck skin)
  • Skin tags along the collar line

7. GLP-1 Agonists (Ozempic, Wegovy): Use, Misuse, and Addiction

• How They Work:
  These mimic a natural hormone to help control blood sugar and appetite by prolonging satiety.
• Risks:
  Dr. Bikman voices concern over widespread, high-dose use for weight loss, citing increased depression and reduced enjoyment in life, not just of food but general interests.
  • "This drug reduces your interest in life and things that you used to be passionate about.” (44:02, Bikman)
• A Better Approach:
  Dr. Bikman suggests short, low-dose, purposeful use to help break carb addictions and build new habits, rather than lifelong reliance.

8. Insulin Resistance and Brain/Hormone Health

• Alzheimer’s as "Type 3 Diabetes":
  Insulin resistance impairs the brain’s ability to absorb glucose, starving neurons; increasing fat burning and ketone availability has cognitive benefits.
• Impact on Hormones:
  • Lowered testosterone in men (fat cells create more aromatase, converting testosterone into estrogen—i.e., “your fat acts like an ovary”)
  • Erectile dysfunction may be an early warning sign of insulin resistance in men
  • In women, PCOS (polycystic ovary syndrome) is closely linked

9. Actionable Advice & Habits

• Diet:
  • Reduce/cut out refined carbs and frequent snacking—not just calories, but carb frequency.
  • Don’t focus on superfoods or metabolism boosters.
  • A diet primarily of protein and fat, with careful carb restriction, can reverse type 2 diabetes in as little as 90 days (based on clinical experience).
• Monitor:
  • Request fasting insulin in your labs, or use triglyceride/HDL ratio as a proxy.
• Behavioral:
  • Recognize carb cravings as addiction—a siren song that often defeats “moderation.”
  • Recruit allies (family, friends) for accountability.
  • Try non-insulin-spiking sweeteners like stevia, monk fruit, and allulose; avoid some sugar alcohols if they spike hunger individually.

10. Sleep, Environment, and Other Factors

• Avoid late-night carb intake—spiking glucose before bed disrupts sleep and triggers sympathetic overactivation.
• Many negative factors (poor sleep, chronic stress, air pollution, light exposure at night) all feed into insulin resistance.

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Notable Quotes & Memorable Moments

• On Addiction to Carbs:
  "No one is sitting around craving a plate of bacon and eggs…They want carbs. Carbs are the one macronutrient that humans crave and dare I say, have addictive tendencies towards." (01:04, Bikman)

• On Treating Symptoms vs. Causes:
  "If the clinician simply says to the patient, 'you have high blood pressure,'...then the next sentence is, 'here’s your prescription.'...If, however, we say, 'you have high blood pressure, which is a consequence of insulin resistance,'...now the next sentence is...let’s change your lifestyle." (09:49, Bikman)

• On Fat Distribution and Ethnicity:
  "The paradox being you actually have the potential to store a lot more fat because you can just keep making new fat cells. But the result is that the fat cells are much smaller, and small fat cells are not only insulin sensitive, they’re also anti-inflammatory." (19:33, Bikman)

• On Treating Obesity with Diet:
  “Within 90 days, every single one of these 11 [type 2 diabetes patients] had reversed their type 2 diabetes by every clinical marker, without ever having taken a single medication.” (62:28, Bikman)

• On Moderation and Addiction:
  "Moderation in all things is one of the most horrific ideologies when it comes to addictive habits...Abstinence is easier than perfect moderation." (66:31, Bikman)

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Timestamps for Key Segments

• [01:04] — Why humans crave carbs, not fat or protein
• [03:49] — Bioenergetics explained: more than a wellness buzzword
• [05:19 – 06:21] — Insulin, not just glucose, as the key marker for disease
• [12:24] — How treating symptoms, not the root problem, sets us up to fail
• [13:27] — Insulin resistance: the two-part pathology
• [16:37] — East Asians & thin people at risk: not just a disease of the overweight
• [20:55] — “Personal fat threshold” and why it’s lower for some ethnicities
• [24:31] — Three drivers of insulin resistance, but carbs are king
• [33:57] — Practical: How to really check if you’re insulin resistant with bloodwork and skin checks
• [36:55] — GLP-1s (Ozempic): moral panic, real risks, and how they might work
• [45:50] — Insulin resistance and the brain: Alzheimer’s as “type 3 diabetes”
• [48:31] — How fat tissue "acts like an ovary" in hormone imbalance
• [51:02] — ED in young men: Pornography AND insulin resistance—a canary in the coal mine
• [59:06] — Cytokines: How fat literally "belches" toxins and hormones
• [62:28] — Clinical results: fully reversing type 2 diabetes with a carb-restricted diet
• [66:31] — "Moderation in all things" myth, and how to build real support to change

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Practical Takeaways

• Get your fasting insulin tested or use TG/HDL ratio (<1.5) to check insulin resistance.
• Cut out refined carbs and snacking; eat mostly proteins and fats; hunger/energy will naturally regulate.
• Be cautious with GLP-1 drugs—treat them as short-term aids for building habits, not magic bullets.
• Insulin resistance isn’t just about belly size. It affects cognition, mood, fertility, sexual and hormonal health—even if you’re thin.
• Abstinence is often easier than “moderation” for carb-centric addictions!
• Late-night carbs can trash your sleep via glucose spikes.
• Don’t despair if you’re already unhealthy—even advanced insulin resistance can often be reversed in weeks or months.

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Final Thoughts

This episode makes a persuasive, practical case that focusing on insulin—rather than solely on calories or glucose—could revolutionize personal and public health. Dr. Bikman’s guidance is empowering, actionable, and candid about both the science and the real-life struggles of building new habits. If you or someone you know wants practical steps to avoid the worst diseases of modern life, this conversation is required listening—and a potent antidote to the myths of fad diets or easy pharmaceutical fixes.

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Recommended:

• "Why We Get Sick" by Dr. Benjamin Bikman (Book referenced throughout)
• Check your lab work for triglyceride/HDL ratio & consider requesting fasting insulin

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For more, visit jordanharbinger.com or search for “The Jordan Harbinger Show” wherever you listen to podcasts.

Transcript

[Jordan Harbinger]

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[Dr. Benjamin Bickman]

Show, no one is sitting around craving a plate of bacon and eggs. It doesn't happen. They're not wanting a stick of butter to be chomping on while they're watching a show on a Friday night. They want carbs. Carbs are the one macronutrient that humans crave and dare I say, have addictive tendencies towards. Based on many conventional definitions of addictive behavior. They seek it, they crave it, they regret it. When they over they can't moderate it is all these aspects of addiction.

[Jordan Harbinger]

Welcome to the show. I'm Jordan Harbinger. On the Jordan Harbinger show, we decode the stories, secrets and skills of the world's most fascinating people and turn their wisdom into practical advice that you can use to impact your own life and those around you.

[Jason DeFillippo]

Our mission is to help you become a better informed, more critical thinker through.

[Jordan Harbinger]

Long form conversations with a variety of amazing folks from spies to CEOs, athletes.

[Jason DeFillippo]

Authors, thinkers and performers, even the occasional Russian chess grandmaster, Emmy nominated comedian, extreme.

[Jordan Harbinger]

Athlete or tech luminary. And if you're new to the show or you want to tell your friends about the show, I suggest our episode starter packs. These are collections of our favorite episodes.

[Jason DeFillippo]

On topics like persuasion and negotiation, psychology.

[Jordan Harbinger]

Geopolitics, disinformation, China, North Korea, crime and cults, and more that'll help new listeners get a taste of everything we do.

[Jason DeFillippo]

Here on the show.

[Jordan Harbinger]

Just visit jordanharbinger.com start or search for us in your Spotify app to get started. My guest today has published over 150 peer reviewed papers, runs an NIH funded lab, and has a PhD in something.

[Jason DeFillippo]

Called bioenergetics, which, let's be real, sounds.

[Jordan Harbinger]

A lot less like science and more.

[Jason DeFillippo]

Like something you'd pay $3.99 for at a weekend chakra alignment retreat. But I promise it's the real deal.

[Jordan Harbinger]

And here's why you should care. He argues that it's not sugar itself.

[Jason DeFillippo]

That'S driving modern disease.

[Jordan Harbinger]

It's insulin, this blood sugar hormone that's actually kind of the boss of your entire metabolism. Half of the adults in the US.

[Jason DeFillippo]

Already have insulin resistance. Most don't even know it. It's quietly wrecking everything from your heart.

[Jordan Harbinger]

To your hormones to your brain. And today we're digging into what insulin really does, how it can tank your health before you even know what's going on.

[Jason DeFillippo]

Why my pants don't fit, I can't see my. You know what? Without a mirror is not the only.

[Jordan Harbinger]

Symptom to watch out for, and most importantly, what you can actually do to fix it before you end up as another scary statistic. All right, here we go with Dr. Benjamin Bickman. Look, I have to say I was.

[Jason DeFillippo]

Skeptical first about having you on because you got a PhD in something called bioenergetics, which first of all sounds like Scientology or something that involves chakras.

[Dr. Benjamin Bickman]

So there is in fact that term has been hijacked by kind of guru spiritual wellness individuals where it really is like harnessing the energy like chakra in your body. It's pretty discouraging. I put my head in my hands when I hear that. But in fact, by all means, let me define it.

[Jordan Harbinger]

Yeah, please.

[Jason DeFillippo]

Because I don't think anybody knows what it is. I think most people are going to.

[Jordan Harbinger]

Go, oh, I've heard of this.

[Jason DeFillippo]

It's getting energy from the earth while you meditate or something. Right.

[Dr. Benjamin Bickman]

Nobody knows the real version. Yeah. So it's a very niche area within science. In fact, when I earned that PhD in bioenergetics, there were only three universities in the entire country. In fact, I think only two at the time. Actually. Now there's three that even offered a degree in bioenergetics. So bioenergetics is a bit of a hybrid degree where it's a combination of a lot of biochemistry and physiology. So physiology is the study of how the systems in the body work. And then of course, biochemistry is the reactions within the cell that allow the cell to live. And then bioenergetics is a bit more of a heavy emphasis on the mitochondria, which is the powerhouse, the energy producing part of the cell. And so it's kind of this. Well, it is a hybrid, but an amalgamation of looking at energy in a very biochemical sense, which is things like calories, nutrients, how you burn things, how you build things. And that is all within the context of biology and the cell. So you take the chemistry part of the biochemistry and then integrate it into. Well, what does this mean in the context of things like obesity and diabetes?

[Jordan Harbinger]

It sounds like, from the book I.

[Jason DeFillippo]

Read, why we get Sick, it sounds.

[Jordan Harbinger]

Like you frame insulin and not glucose.

[Jason DeFillippo]

As this sort of upstream driver of almost every. What's the word?

[Jordan Harbinger]

Cardiometabolic disease, from type 2 diabetes to some cancers.

[Jason DeFillippo]

Is that a fair summary?

[Dr. Benjamin Bickman]

Yeah, it is, yeah. So that's a view that I believed, and still do, was sufficiently poorly understood that someone needed to kind of harness that message and encapsulate it. While I love academia, I also get frustrated by the limits we place on ourselves, which is we're content to just know something because we think the knowledge itself has value and we can't be bothered to wonder whether the idea actually has some legs to it in the real world. But yeah, I attempted to articulate those points in the book, but again, as you stated, the central premise of this is that as much as we have a glucose centric paradigm of metabolic health, you know, you go in and get a blood test every time they're measuring glucose or your hemoglobin A1C, they will never measure insulin. So our obsessive focus and zeroing in on glucose actually has us missing the more important marker. Because if we can reframe the paradigm to focus or at least include insulin, we not only detect these cardiometabolic chronic diseases much, much sooner, but we also treat them much better.

[Jason DeFillippo]

We used to get sick from infectious diseases, right? Cholera and all these. Well, now they're kind of. We're getting a resurgence of some of this, but more or less this isn't true anymore. I'm not worried about my kids getting dysentery like the Oregon Trail. That's not going to happen. Now people are getting sick and dying from what is called metabolic disease.

[Jordan Harbinger]

So tell us what this is. Because unfortunately, the word metabolism has also.

[Jason DeFillippo]

Been sort of hijacked by the fitness and wellness people, where it's like, you.

[Jordan Harbinger]

Got to eat this to get your metabolism going.

[Jason DeFillippo]

And my trainer's like, dude, your metabolism.

[Jordan Harbinger]

Has not stopped because we are.

[Jason DeFillippo]

You are not dead on the floor.

[Jordan Harbinger]

That's when your metabolism stops. You don't need to eat broccoli or.

[Jason DeFillippo]

Superfood or drink this kind of thing to get your metabolism going.

[Jordan Harbinger]

And metabolic disease doesn't mean you're not digesting food right.

[Jason DeFillippo]

It's totally different. So tell us what this actually means.

[Dr. Benjamin Bickman]

No, that's a really, really good question, particularly right now, while we are enjoying a moment where a lot of public health professionals at high levels are talking about metabolic health, quote, unquote. And so I think it is in our best interest to make sure we have a common definition of that term, because metabolism does mean. It almost means whatever a person wants it to mean. There are as many different definitions of metabolism as there are people to invoke the term. So as a scientist within the realm of metabolic research, I think the most apt definition is actually one that your trainer is alluding to, which is that metabolism is the sum of all chemical reactions happening in a cell at any moment. And then it is defined. You can then one layer down, break metabolism and all metabolic reactions up into two categories. Anabolic reactions, those reactions that are building up molecules, and then catabolic reactions, those biochemical reactions that are breaking things down. Now, even still, with that definition, someone could say, well, what does that have to do with metabolic health? Right. So here's where I think the best definition comes in. In fact, let's think sort of down two steps. I think it'd be easy for someone if we could all agree, we would say, okay, the maybe simplest definition is to look at it through the lens of the metabolic syndrome. After all, they both have the word metabolic in them. And the metabolic syndrome is this cluster of complications that always clumps together. Things like elevated waist circumference, elevated blood glucose, elevated blood pressure, and then dyslipidemia. Your blood lipids, your triglycerides in your HDL are a little out of whack.

[Jordan Harbinger]

Did you say elevated waist circumference?

[Jason DeFillippo]

That is.

[Dr. Benjamin Bickman]

Yeah.

[Jordan Harbinger]

That is the best PC term for.

[Jason DeFillippo]

Being fat that I've ever heard. Yeah, yeah, yeah, yeah.

[Dr. Benjamin Bickman]

But I do need to emphasize that it is specific to that middle of the body.

[Jason DeFillippo]

I see.

[Dr. Benjamin Bickman]

You know, it's that truncal fat. And so that's why I have to just point it out a little bit more than just saying you're chubby, because where you hold fat matters tremendously. So that's the metabolic syndrome. But then even still, someone could say, but why are all those metabolic. What do they all have to do with each other? That's where I think we take it down to the final foundational layer, which is what we call the metabolic syndrome. Used to be called the insulin resistance syndrome, and now we've actually come to the cause of it all. If we can say metabolic health, but be thinking, what is your insulin resistance status? Now we are really talking about some productive terms.

[Jason DeFillippo]

Okay, so this is maybe not what kills us, but this is what makes us sick. And then somebody comes in and says, oh, cardiac arrest due to high blood pressure.

[Jordan Harbinger]

And you're saying, okay, they put a.

[Jason DeFillippo]

Period at the end of that. But what I. It sounds like what you're saying is cardiac arrest due to high blood pressure due to insulin related resistance and the chain reaction of things that happens when that's elevated for, I don't know, like 30 years or something.

[Dr. Benjamin Bickman]

That's exactly right, Jordan. Yeah, you nailed it. Where I would say, and again, this does have real world ramifications, because if the clinician simply says to the patient, you have high blood pressure, then if it stops there, if there is a period, as you said, then the next sentence is, and here's your prescription for a drug.

[Jordan Harbinger]

Right?

[Jason DeFillippo]

If, however, address this symptom.

[Dr. Benjamin Bickman]

Yeah, exactly. If we say you have high blood pressure, comma, which is a consequence of insulin resistance, period. Now the next sentence is in response to maybe the patient's question, what do I do about it? Okay, well, this is a lifestyle problem. So now we start to change your lifestyle. And that's why you see so consistently, blood pressure drops so quickly as a person just directly makes lifestyle changes to improve their insulin resistance.

[Jordan Harbinger]

So When I was 33, I had 39% body fat, I think, which is not good.

[Jason DeFillippo]

For those of you keeping track at home, that's not good. Right Now I have 12. And most people wouldn't say, you're so.

[Jordan Harbinger]

Skinny, put some meat on, right?

[Jason DeFillippo]

I just look like a normal person. So I had 38, 39% body fat.

[Jordan Harbinger]

And the doctor, I went to one.

[Jason DeFillippo]

Of those, like, CEO health checks where they have you running on a treadmill and they take blood work, takes like eight hours. You know, they're doing all the scans and the guy was like, your blood pressure is high. You're insulin resistant. It's called pre diabetic or whatever.

[Jordan Harbinger]

And he's like, but it's not quite pre diabetic. It's like pre, pre diabetic.

[Jason DeFillippo]

Bear in mind, again, I was 33 at the time and I said, oh.

[Jordan Harbinger]

I have a prescription for blood pressure.

[Jason DeFillippo]

Medication that I just got from my doctor. And this guy goes, look, I'm not your doctor. I am a doctor.

[Jordan Harbinger]

You really should not be taking that.

[Jason DeFillippo]

For the next 50 years of your life. He's like, what you should do is.

[Jordan Harbinger]

Get in shape, because if you lose a bunch of weight and you start.

[Jason DeFillippo]

Eating right, your insulin resistance is going to go down. And I bet. And even though it's genetic, you know, partly your blood pressure is also going to go down and you probably don't actually need it.

[Jordan Harbinger]

You're just fat.

[Jason DeFillippo]

And he's like, I'm not trying to be mean, you know, he basically was just like, look, get a second opinion, please. Again, I'm not your doctor, but I.

[Jordan Harbinger]

Took it to heart.

[Jason DeFillippo]

I got, I went on a diet, I got a trainer. I didn't do it right away, which I should have, but I lost 50 plus pounds of fat. I got in really good shape.

[Jordan Harbinger]

And I do measure my blood pressure every day. I went from high blood pressure to completely normal blood pressure.

[Jason DeFillippo]

I went from insulin, super high insulin.

[Jordan Harbinger]

What was it called? A1C. The thing you mentioned earlier, that was.

[Jason DeFillippo]

Like off the charts bad, and now it's really good. My cholesterol was like 150. Now it's 75. One of, one of them triglycerides, I think.

[Jordan Harbinger]

And all of the bad numbers became.

[Jason DeFillippo]

Good just because I stopped eating as much and I got into shape physically.

[Jordan Harbinger]

It, it's hard to sort of overstate.

[Jason DeFillippo]

How much you can fix with lifestyle because you're hitting that downstream effect that you mentioned, right. You're getting, you're managing the insulin. So the blood pressure, the cardiac arrest, the brain, all this stuff is just like, it doesn't have a chance to develop.

[Dr. Benjamin Bickman]

It's downstream. Yeah, Downstream stream, as you said. Yeah. If we can drill down to the base foundation and say sometimes we'll use the analogy of a tree where chronic disease nowadays in medicine is like a tree where we are looking at each little branch of this diseased tree and we're saying, Jordan, you have high blood pressure, so we're going to just trim off these little branches with the blood pressure medication. Or maybe you've got erectile dysfunction. We're going to trim at that little branch and here's a medication, and we're never actually just looking at the whole tree and say, why don't we just chop the whole thing down? And so when we can acknowledge that all of these are simply branches off of one same core or truncal problem, namely insulin resistance, then that allows us to actually address the cause rather than the symptoms.

[Jason DeFillippo]

I like this. And fortunately, I also read in your book that insulin resistance is one of the most common conditions worldwide, which is scary. And I'll say scary, right? Because now you have to tell us what insulin resistance is, because I'm not sure I actually know what it means. I know a lot of people listening certainly don't.

[Jordan Harbinger]

But if this is one of the.

[Jason DeFillippo]

Most common conditions worldwide and it's bad, tell us what it is and how it causes other diseases.

[Dr. Benjamin Bickman]

Yeah, of course. That's great. Yes. So insulin resistance is a pathology with two parts. So there's two aspects to this disease. There's two sides to the coin. There's the one side which gives us the term itself, which is the fact that in the body, some cells are not responding well to insulin, so they've become resistant to insulin's signal.

[Jason DeFillippo]

Okay, so it tells other things what to do in your body.

[Dr. Benjamin Bickman]

That's a perfect description. That's what hormones do. Hormones are simply messages that are sent from the body telling the cells what to do. And every cell, importantly, this does matter. Every single cell of the body has insulin receptors on it. These little docking stations that are specific for insulin to come and dock and then tell the cell to do something. But again, with insulin resistance, some cells aren't working particularly well. But then that's one half of the problem. When we flip the coin over, this one coin that I'm calling insulin resistance, we have to consider the other part of this, which is that within the body, blood insulin levels are much higher than they were before. So that's a condition called hyperinsulinemia. So insulin resistance is two things. One, insulin isn't quite working well, and then second, insulin levels are much higher. That two part definition is critical. To understand how insulin resistance as a collective term can create so many different pathologies where it is, how can it contribute to Alzheimer's disease and atherosclerosis and hypertension and infertility in both male and female, et cetera, we have to keep both definitions in mind. But one other part of this, when we look at the global level, let me just really put a fine point on that. I was actually invited to do my. What's called a Postdoctoral fellowship in Singapore, of all places. So after I finished my PhD in bioenergetics in North Carolina, I knew I wanted to continue to pursue science and have the life of an academic as a good means to an end, to provide for my family. It was a job that I wanted. And so to do that, getting a PhD is not enough. You have to do something called a postdoctoral fellowship. I did mine in Singapore with the Duke Medical School. Now, of course, Duke has an elite medical school. They partnered with the government of Singapore to create a very high level elite medical school with a heavy emphasis on metabolism research, like diabetes. And type 2 diabetes is the most obvious outcome of insulin resistance. You think about insulin and its main job, controlling blood sugar. Well, when insulin's not working well, blood sugar goes up, and now you've got type 2 diabetes. But in Singapore, this beautiful country in Southeast Asia, one of my children was born there. We love it there. We just went there for spring break this year. We love it. Interestingly, you walk on the streets of Singapore and you would look at the average Singaporean of predominantly East Asian descent, so Chinese descent, primarily, and you'd be surprised at how few chubby people there are. Maybe they're a little chubby, someone's a little chubby. But you walk on the streets of the United States with blacks and whites being the primary ethnicities, and we have a lot of obesity here.

[Jason DeFillippo]

Yeah.

[Dr. Benjamin Bickman]

And yet, as much as we are as a country fatter than Singapore, we have less insulin resistance and less type 2 diabetes than they do.

[Jordan Harbinger]

What?

[Dr. Benjamin Bickman]

Yeah. As a percent of the population, the United States, when it comes to type 2 diabetes, as a formal diagnosis, we are about country number 70 or so, whereas Singapore has been as high as number nine. I think they might be in the low teens right now.

[Jason DeFillippo]

So it's not just about being fat.

[Dr. Benjamin Bickman]

It's not just about being fat. That's a. I don't want to force the conversation too early into the origins of insulin resistance, but how we store fat actually matters much more than how much fat we're storing.

[Jason DeFillippo]

Okay, I want to get to that in a little bit because I. I do find that's super interesting. I wouldn't have expected that.

[Jordan Harbinger]

However, if you go to China, you.

[Jason DeFillippo]

Will see a lot of fat people.

[Jordan Harbinger]

I was shocked. I was thinking like, you guys, we gave you Kentucky Fried Chicken, but you got to use it responsibly. What is going on here? It. It starting to look like Michigan over here.

[Jason DeFillippo]

Come on.

[Dr. Benjamin Bickman]

And in fact, no surprise, no surprise that they have higher rates of type 2 diabete than we do.

[Jason DeFillippo]

Look, I probably am a little bit biased because I have a skew, right? I live in California. And so people are like, I don't know anybody that buys frappuccinos, for example. I'm sure obviously a lot of people do that, but I don't know people that drink Slurpees.

[Jordan Harbinger]

But in China and in Asia, you go, and you get a bubble tea, you know, those boba teas, and you go, oh, okay. And if you forget to say no sugar, it is like a 100% saturation.

[Jason DeFillippo]

Of sugar in milk tea.

[Jordan Harbinger]

And you just feel your teeth like.

[Jason DeFillippo]

Dissolving with every sip.

[Jordan Harbinger]

It's worse than Coca Cola. And people will drink and eat treats like that constantly.

[Jason DeFillippo]

And my wife, who's East Asian from.

[Jordan Harbinger]

Taiwan, she goes, yeah, but you don't see any fat people. It's gotta be genetic. And it sounds like what you're telling me is it doesn't matter if they're fat, they're still all sick with the.

[Jason DeFillippo]

Same stuff you get even if you're fat.

[Dr. Benjamin Bickman]

Yeah, Some ethnicities simply have a potential to get fatter. And again, I don't want to pull us into that too soon. But some ethnicities, like blacks and whites, for example, as different as many people would claim we are as ethnicities, one thing we have in common is that we make more fat cells more easily than many other ethnicities do. And that gives us this paradoxical situation where in blacks and whites and all ethnicities are on this spectrum, where on one end we have blacks and whites, we make fat cells more readily than most other ethnicities, but because of that, all of the fat cells we have are smaller. And that's where the rubber meets the road. It's the size of the fat cell that matters and not the mass of fat. Then on the other end of that spectrum you have people like, of East Asian ethnicity where they have a very limited potential to make new fat cells. So any fat that they're gaining is forced to be stored in fat cells that are getting increasingly or ever larger in volume. The technical terms are hypertrophy when it comes to fat cells getting bigger because we aren't making new ones, versus hyperplasia where you're making new fat cells. Which means again, the paradox being you actually have the potential to store a lot more fat because you can just keep making new fat cells. But the result of that is that the fat cells are much smaller and small fat cells are not only insulin sensitive, they're also actually anti inflammatory, which helps with the Overall health profile of the person. So here, the United States is a good example. Although we are not even the fattest country on the planet, thank you very much. We're neither the fattest, nor the dumbest, nor the most diabetic. In defense of.

[Jordan Harbinger]

Are you sure I want to see the data?

[Jason DeFillippo]

I know it's surprising to see the data, but.

[Dr. Benjamin Bickman]

But we are, we are fat.

[Jason DeFillippo]

Yeah.

[Dr. Benjamin Bickman]

But we are healthier than other countries that are much less fat. And again, it's because we have more but smaller fat cells than East Asians, South Asians, Hispanics. They're all on that other end of the spectrum of having a limited potential to make new fat cells. And so a little bit of fat. If you take an East Asian version of me and you, you put ten pounds on that version of us versus ten pounds on this European version of us, the European version. We just don't look as good in our Speedo. The East Asian version we've got prediabetes and hypertension.

[Jason DeFillippo]

Oh, I see. So the bar for them to have the same problems with the same level of fat, it sounds like it's lower.

[Dr. Benjamin Bickman]

That's a perfect metaphor because what the term that is often used when I actually teach this as a lecture, I use the term personal fat threshold.

[Jason DeFillippo]

Yeah, yeah.

[Dr. Benjamin Bickman]

And I actually animate in a little bar on a body and say, you know, so a person with a very low fat threshold, that'd be like the East Asian body where a little bit of fat and you're already, you've already gone too far. But the bar on the northern European body is much, much higher. So you can have a lot more fat before you reach that critical threshold where it starts to become a problem.

[Jordan Harbinger]

That makes sense because when I was.

[Jason DeFillippo]

40% body fat, I had problems. But when I was probably like 35 or 32% body fat, my blood work still looked OK. Okay. You know, I looked chubby, but it was like. Unfortunately most of it was visceral. So between my organs.

[Jordan Harbinger]

So I carried it really well.

[Jason DeFillippo]

And people would always say there's no.

[Jordan Harbinger]

Way you lost 50 pounds. Because I bear, I didn't really look.

[Jason DeFillippo]

That different, but my organs were like, ah, I can move in here again. Oh my God.

[Jordan Harbinger]

Thank you. Right.

[Jason DeFillippo]

I mean, they were just getting crushed by fat between all of my or, which is I guess what raises blood pressure. Right. When something's getting. There's a friggin balloon full of fat between each of your organs, pushing on everything.

[Dr. Benjamin Bickman]

Yeah, visceral. Visceral fat cells are actually more problematic subcutaneous fat cells. So the human body will primarily store fat in two depots, subcutaneous, which is the fat that we can jiggle and pinch. That's the right beneath the skin, and that has a potential to grow out. And so if you are having more fat stored subcutaneously, you're making more fat cells because you can just keep pushing it out. Visceral adipose, because of the volume limit, will only grow through hypertrophy. So 10 pounds of visceral fat will have a much greater consequence on Health than 10 pounds of subcutaneous fat, because those visceral adipocytes will not grow through hyperplasia. They will not multiply, because then you begin to physically compress too much. So they become very hypertrophic, which promotes insulin resistance and inflammation. And the way they contribute to blood pressure is that the more you're increasing insulin, the more you're actually forcing the kidneys to retain salts and water, which just increases blood volume, which in turn increases blood pressure.

[Jason DeFillippo]

I see. Yeah.

[Jordan Harbinger]

This is interesting.

[Jason DeFillippo]

And this is one of the reasons why, now that I'm in shape, one of the reasons I want to stay in shape forever is because I look and feel good.

[Jordan Harbinger]

But two, I realize that my personal.

[Jason DeFillippo]

Fat threshold, even for, I guess, a.

[Jordan Harbinger]

White person, is a little bit lower because my genetics are, hey, let's store all of this between your organs before.

[Jason DeFillippo]

We start making your waistline bigger. Whereas, like other folks, even in my.

[Jordan Harbinger]

Own family, they'll get a huge belly. But nothing changes because their fat is.

[Jason DeFillippo]

All in the front or the sides, they get love handles.

[Dr. Benjamin Bickman]

That's absolutely true. So that's an important point where even within the same ethnicity, you can have a tremendous variance, but also it explains the difference between sexes. Hypertrophy also explains within the same ethnicity why females are invariably fatter than males and healthier at the same time. If it was just a matter of fat mass, every woman would be sicker than her male counterpart with cardiometabolic problems because females are naturally fatter due to sex hormone differences. But they're not, because females, again, because of sex hormones like estradiol, will start to not only store fat subcutaneously more than men, but also activate more fat cell growth as needed. And so they'll stimulate the creation of new fat cells. So women will be fatter than men, but because they have more but smaller fat cells, they will invariably be more protected against these cardiometabolic problems that come from insulin resistance.

[Jordan Harbinger]

So what are the maybe top three.

[Jason DeFillippo]

Lifestyle factors that spike insulin all day long? Are we talking about, like, meal timing.

[Jordan Harbinger]

Or ultra processed foods and weird stuff that we're eating or carbs? What's the villain here?

[Dr. Benjamin Bickman]

Yeah, right, yeah. So that question touches on what are the kind of cardinal causes of insulin resistance? I believe that there are three actually worth noting. I will mention them in order of increasing importance. Two causes are relevant, but they're also things that you can't control too readily, which is stress and inflammation. Stress. And I define that as a professor who teaches endocrinology. So a class in hormones. Stress is really defined by the elevation of the two primary stress hormones, adrenaline. In the US we call it epinephrine, Actually, epinephrine and cortisol. So those two hormones, when they're up, they will promote insulin resistance. But there's only so much you can do, you know, like if someone says, well, my cortisol's up, what can I do? We'd say, well, calm down. And they'd say, well, now I'm even more stressed because I can't calm down, you know, so as much as it's a variable, it's also one you can't really. It's a lever you can't really control very well. The next one is inflammation. Inflammation causes insulin resistance, but again, that's a slippery lever. You can't really move it very well. It depends on some variables that may be outside of your control. But thankfully, both of those are more modest than the main one, which is the one you asked the question with, which is insulin itself. A fundamental feature of biology is that too much of something will generally result in a resistance to that something. And then that brings us to insulin. If we are living a lifestyle and eating a diet that is constantly raising our insulin, the body starts to become resistant to that signal. And then what? We then can logically just come to the conclusion of asking what spikes insulin the most? And that's of course, starches and sugars. So refined carbohydrates. I point the finger solidly at that as the primary culprit. That we have a culture of not only eating all the time and drinking. In the case of the bubble tea, it's a perfect example where we eat and drink refined starches and sugars almost all day. Certainly, as far as insulin is concerned, it is all day, because it will take insulin anywhere from three to four hours to come down after someone's had a big carb heavy meal. The average individual worldwide at this point, from the Middle east to East Asia to Southeast Asia to North and South America, through Europe and everywhere. The average individual spends every waking moment in a state of elevated insulin. Insulin has come down overnight. Just to put all this in perspective, overnight we've been fasting just because we've been asleep. Ideally, we wake up in the morning and the global first thing in the mouth is going to be something sugary and starchy again. It doesn't matter where you are. That's become common. And so we spike our insulin and then a couple hours later, we do it again with a mid morning snack. We do it again more dramatically with a big lunch and then an afternoon snack and then a dinner. And then of course, we need a snack or two in the evening. And so it is several hours into our sleeping moments before insulin finally comes down. And so that's why I say insulin matters more than the other variables. But then it matters even more because it's also one that you can immediately start to change by just cutting out those carbs.

[Jordan Harbinger]

Insulin resistance might shorten your lifespan, but these sponsors will make your remaining years a little bit more comfortable. We'll be right back. This episode is sponsored in part by Cayman Jack, America's number one margarita. We had a little backyard hang recently.

[Jason DeFillippo]

Just a bunch of us friends catching up, snacks on the table, music playing, you know, that kind of thing. A few lawn games that somehow get way too competitive. You know how it goes.

[Jordan Harbinger]

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[Jordan Harbinger]

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[Jason DeFillippo]

People were really into it. Like, really into it. Someone even was like, oh, is this bottled?

[Jordan Harbinger]

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[Jordan Harbinger]

This episode is also sponsored by Factor. Between two kids schedules taping the show.

[Jason DeFillippo]

And pretending I have a social life.

[Jordan Harbinger]

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[Jason DeFillippo]

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[Jordan Harbinger]

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[Jason DeFillippo]

Yeah, you're not booking guests for a.

[Jordan Harbinger]

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[Jason DeFillippo]

Let's say that we get blood work done pretty regularly for Americans, which is what, annual or something? If that, right? I do it every probably 10 weeks, but that's because I'm terrified of death, but and also because I spent my whole life not caring and not paying attention and now I'm trying to make up for lost time. And I'm experimenting with things, but that's neither here nor there.

[Jordan Harbinger]

But so from my point is, most.

[Jason DeFillippo]

Of us are not paying attention to this stuff or we get blood work and our doctor goes, looks fine. And you go, all right, you don't really know that he meant looks fine for a 60 year old man. Even though you're 24, right, you're within the normal range and that's all you care about. Are there other non obvious signs that listeners should watch out for or viewers I should say as well, what if we're tired all the time or I've got a bunch of weird marks appearing on my skin? I mean, is there some kind of obvious thing that we can see with our eyes?

[Dr. Benjamin Bickman]

So let me just reiterate the first point and revisit it just briefly. I would strongly encourage anyone who can to get their fasting insulin measured. So next time you go in actually for a lab test, try to buck the trend of insulin never being even discussed and say, hey, can you check that box there and actually measure my insulin? And if you can get a clinician to do that for you, you want to see your insulin somewhere below about 6 micro units per mil. So if you see that lower number, single digits, that's a really, really good sign that you're insulin sensitive. If you aren't able to convince your clinician to measure insulin, then look at your lipid markers, take your triglycerides number and divide it by your HDL cholesterol number. And if that ratio, the triglycerides divided by HDL is less than around 1.5, even better, less than 1, that's a really good sign that you're insulin sensitive. And so your metabolic health is going to be somewhere good if that number is down by close to one or even lower. Now, if you aren't relying on a blood test, then actually you mentioning the skin is a good one. Skin is a window to the metabolic soul. And interestingly, you can see the two most common skin features right around the collar line of the neck. One of them is a condition called acanthosis nigricans, which is a term, a complicated term, referring to the skin changing in both texture and color. And with the color it simply starts to get a little darker pigmented and so the melanin expression starts to change a little bit and the skin gets a little darker. Now, depending on the ethnicity, it might be hard to tell if the skin is darker, as the skin may naturally be darker across ethnicities. But thankfully that's where the other part of this comes in, which is that the skin also starts to take on the form of like a crinkled tissue paper. So it's a very kind of wrinkled, deep wrinkled, crinkled skin. And you can very much see that and feel it. So that's one skin condition. There's another one, commonly called skin tags. It's like a teeny little column of skin just jutting right up. And people probably can. They know what I'm talking about. They've seen it before, but it's these small, little. Well, little mushroom stalks of skin. And they're small, but you'll see them kind of dangling up like. Almost like a teeny little finger poking up out of the skin. And those are both very common manifestations of insulin resistance. Thankfully, there are also ones that can go away quite quickly as the insulin resistance improves.

[Jason DeFillippo]

Yeah, that's good to know.

[Jordan Harbinger]

What was the.

[Jason DeFillippo]

By the way, I'm looking at my blood work now.

[Jordan Harbinger]

What was the two things you divide into one another?

[Jason DeFillippo]

Triglycerides.

[Jordan Harbinger]

And what was the other one?

[Dr. Benjamin Bickman]

Triglycerides divided by HDL.

[Jason DeFillippo]

Okay, so this is old blood work, but 40 divided by 60.

[Dr. Benjamin Bickman]

If that's below one and a half, that's great.

[Jason DeFillippo]

Let me try this right now.

[Jordan Harbinger]

40 divided by 60.66.

[Dr. Benjamin Bickman]

Oh, yeah, you're laughing. That's great.

[Jason DeFillippo]

Oh, that makes me feel better.

[Jordan Harbinger]

I wish I tested insulin.

[Dr. Benjamin Bickman]

That's a very, very good sign.

[Jordan Harbinger]

Yeah, tell me about.

[Jason DeFillippo]

And I'm sure you have a whole.

[Jordan Harbinger]

Rant on this, but tell me about.

[Jason DeFillippo]

GLP1 agonists, aka Ozempic and stuff.

[Jordan Harbinger]

Because isn't this why people. Isn't insulin what this was originally for?

[Dr. Benjamin Bickman]

Yes. So these. Semaglutide, which is the main drug that has been now labeled as Ozempic and Wegovy and there are a few other drugs. If anyone is wondering about the drug. If you are looking at a drug and it has the ending of glutide or utide, it's going to fall within this family of drugs, which is mimicking the actions of a hormone that we all make in our intestines called GLP1. So we all make GLP1. It's a hormone and it has beneficial effects for metabolic health. One effect is to help improve blood sugar. It's to help blood sugar control by telling the liver to hold on to glucose and not be releasing it into the blood. But as GLP1 levels go up, there are these other effects that help with appetite. One is that it will slow the Movement of food through the intestines so you just feel fuller for longer. And then second complementing that is that GLP1 as a hormone will tell the brain. It will activate satiety centers in the brain. So the brain will be at that top level telling the body, hey, we're not hungry, we don't need to eat. So those complement each other quite well. So all of that was leveraged into these new drugs, like semaglutide being the main one. What's interesting is that while I have very strong reservations about the current use of these drugs, I believe they're used too readily for the wrong purpose and at too high of a dose. And the purpose matters because when we talk about these drugs, we talk about them as weight loss drugs. And that may give the person this mistaken view that as long as they're injecting, they're good to go and they don't need to worry about anything. And I think that's the wrong way of looking at it. Which leads to problems of people having profound nausea and even depression and suicidality. Those are all increased risks with the use of this drug. And I think it's because it's too much of a good thing. Now, if you'll allow me, let me kind of make a different use case for the drug. There was a paper published in 1996 which documented the GLP1 response in humans to eating a high carbohydrate meal and a high fat meal. And they noticed differences and they looked at the subjects of the study based on whether they were lean or obese. And when lean and obese people ate a high fat meal, the GLP one response was very similar. It had a lot of overlap. So one way of interpreting that would be to say that whether you're lean or obese, if you eat a high fat meal, you get a roughly equal degree of satiety. In as much as GLP1 is a satiety hormone, it makes us feel full, makes us want to eat less, then that is going to be equal, regardless of your body fat.

[Jason DeFillippo]

Can I guess the rest of this, please? So the fit people versus the obese people eating a high carb meal, the satiety was wildly different. And the people who were obese were not satisfied after eating even a high carb meal.

[Dr. Benjamin Bickman]

Yeah, exactly. So, in fact, there was literally, Jordan, there was no response. When they looked at the GLP one response to the high carb meal, it stayed within the normal range and it did not reach a point of statistical significance at all. In the obese people, Whereas in the lean group, it went fantastically high and stayed elevated for about three hours. And so all of this is to say that we should have empathy, that if we are sitting at a table and we're going out for pasta and garlic bread, someone is going to eat a certain amount of that and feel full. In part because of GLP1, someone's going to eat a certain amount of that and not feel full and simply be looking around for the next plate of pasta and garlic bread. So to me, that suggests a better way of using these drugs. Because if we can then say to the person, you have a carb problem, and let's face it, people who are overweight, obese and diabetic, no one is sitting around craving a plate of bacon and eggs. It doesn't happen. They're not wanting a stick of butter to be chomping on while they're watching a show on a Friday night.

[Jason DeFillippo]

That's interesting. Yeah.

[Dr. Benjamin Bickman]

They want carbs. Carbs are the one macronutrient that humans crave and dare I say, have addictive tendencies towards, based on many conventional definitions of addictive behavior. They seek it, they crave it, they regret it. When they over, they can't moderate it is all these aspects of addiction. So we say to them, let's give you this drug to help you learn to eat differently and have a different relationship with food. And we're gonna start it at a lower dose, what you could even call a microdose. And we're gonna put you on a 90 day cycle. Remember, this isn't a weight loss drug. So we frame it properly. We say, this is a drug to help you control your carbohydrate cravings or addictions, depending on the person. And then we check on them. We say, how are you doing? How are your carb cravings working? They're getting a little better. And as they start to learn to change their habits and learn what it feels like, 90 days is enough for many people to actually cure an addiction. And so around at 90 days, let's wean them off, let's cycle off the drug, and let's see whether some of these habits have stuck. And some people, they have. And I know this from just anecdotal evidence of people, I know other people, it sticks for a while, maybe a month or two, and then it starts to fade and their habits are returning and they're starting to gain weight again. Then we say, all right, let's cycle you on again.

[Jordan Harbinger]

Is that in part because they didn't.

[Jason DeFillippo]

Build habits, they were just injecting a weight loss drug and they were like, they didn't go to change their diet.

[Dr. Benjamin Bickman]

When it comes to addictions, I am admittedly a little out of my wheelhouse where I can't articulate necessarily the variables that might go into one person being able to change habits and one person not. That's true, but even still, I think it's important that we frame the conversation outside the context of just weight loss. And we say this is a drug to help you change your habits. And then the person is more mindful where in the evening, if they are now starting to crave five bowls of cereal, they will remember, hold on, wait. I'm taking this drug to help me control these carb cravings. And I think there's something to be said for that little bit of placebo kick where if they're thinking about the drug in the proper framework, I believe firmly that they're going to get a little more help.

[Jordan Harbinger]

I'm glad you brought up the satiety thing because it's really easy for people.

[Jason DeFillippo]

To kind of be mean to overweight folks and be like, you just need to try harder.

[Jordan Harbinger]

But I know from going on a.

[Jason DeFillippo]

Diet and losing all that weight myself without drugs. I was talking to a bodybuilder who diets for contests. He was describing how hungry he was at certain calorie levels.

[Jordan Harbinger]

And I was like, I don't really experience that. I'm a little hungry.

[Jason DeFillippo]

But then I just hit my 1400 or I was at like 1300 calories for a while, which is ridiculous. And he's like, and you didn't get angry and, you know, kick the dog and try to bash the door down and rip the refrigerator off its hinges? And I was like, no, I just went to sleep.

[Jordan Harbinger]

And he's like, you have a superpower.

[Jason DeFillippo]

For controlling your hunger.

[Jordan Harbinger]

And it made me realize that, like.

[Jason DeFillippo]

If I didn't have that, I just would have eaten chocolate covered Rice Krispies or whatever the heck we got in the pantry here for the kids until I hit my 2,500 calories or something, I would have busted my diet.

[Jordan Harbinger]

And so any sort of drug that.

[Jason DeFillippo]

Can help people change their habits I think is fair.

[Jordan Harbinger]

I want to push back a little, play devil's advocate, maybe a little bit too. Even if you took GLP1 forever, semaglutide, whatever, forever, isn't that still healthier than being obese? Because obesity, reading your book, it just.

[Jason DeFillippo]

Basically is one of the worst things that can ever happen to your body.

[Jordan Harbinger]

So Unless these drugs kill you in some other way.

[Jason DeFillippo]

And even if they do, maybe it's.

[Jordan Harbinger]

Kind of better to still live with.

[Jason DeFillippo]

That and then not be obese because.

[Jordan Harbinger]

Like maybe you lost some bone and.

[Jason DeFillippo]

You lost some muscle and you need to work on that. But you don't have high blood pressure, you don't have joint pain, you don't have cardiac issues or whatever. You don't have social stigma that you're dealing with.

[Jordan Harbinger]

You don't have confidence issues you're dealing with.

[Jason DeFillippo]

It kind of seems like Even the worst GLP1 ozempic addiction is better than being 100 pounds overweight.

[Dr. Benjamin Bickman]

That's a really, really good counter. In fact, I, as a scientist, just to help everyone appreciate it, I'm one of those old fashioned scientists where I just pursue truth. To be a good scientist and I hope I am one. In all humility, I hope I am one. You have to be prepared to dump every theory you have the moment the data proves you wrong. And so you have to be humble and open minded to counter points. What would be the counter to that? So first of all, I don't know. In the absence of data, I can't say whether it would be better. But the data we do have are pretty clear. Like if you tell someone you're going to be on this drug for the rest of your life, it's telling that 70% of users of these drugs in the United States get off the drug of their own volition at two years. They don't want to keep taking it.

[Jason DeFillippo]

That's great.

[Dr. Benjamin Bickman]

They basically say I'd rather be fat.

[Jason DeFillippo]

Oh, never mind, I spoke too soon. I thought you meant it worked.

[Jordan Harbinger]

Did they get off the drug?

[Jason DeFillippo]

Not I'd rather be fat?

[Dr. Benjamin Bickman]

No, no. Well, I mean, maybe some people would say, well, I lost the weight I wanted, now I'm off. But they gain it all back within a year. That's very clear.

[Jason DeFillippo]

I see.

[Dr. Benjamin Bickman]

In fact, they end up fatter because of the muscle and bone loss which will not come back. The fat mass rebounds fantastically quickly. So 70% of users, they get off the drug at two years of their own choice. Now coincidentally, at that same two year period, a study was published just within the past few months finding a 200% increased risk of major depression in these people that go on the drug compared to placebo, a 100% increased risk of suicidal behavior. So there is something about these drugs where they would rather be fat than feel the way they're feeling. And so maybe one way of articulating this now this is My own opinion here, as much as we talk about these drugs as. And I don't even mean for this to sound like I'm universally opposed, I hope I've articulated what I think is a use case for these drugs.

[Jason DeFillippo]

Yeah, it doesn't sound like you are.

[Dr. Benjamin Bickman]

So one way of looking at the drug as much as we. We put a very favorable light on it by saying this drug helps you control your cravings and you crave these carbohydrates less. Maybe if we're being a little more honest, we would say this drug makes you less interested in things you used to be interested in. And a person was interested in carbohydrates and snacking on salty and crunchy and sweet and gooey foods, which is good to control. But they might have also been interested in going and playing pickleball with their friends. Now they don't really care to do that as much as they used to. They might have been interested in getting together with the girlfriends and going on a walk around the block every evening, and they don't really do that anymore. Maybe the more honest view is that this drug reduces your interest in life and things that you used to be passionate about.

[Jordan Harbinger]

Yeah, that's scary. In fact, that totally jibes with something.

[Jason DeFillippo]

I'd read about these a couple of months ago, which is that they might.

[Jordan Harbinger]

Have a role in treating certain addictions.

[Jason DeFillippo]

I don't know if you've seen this data, but it was something like they were using glp, one antagonist for addiction.

[Jordan Harbinger]

Which totally makes sense if you look.

[Jason DeFillippo]

At carbs as an addiction, and then you realize it makes people depressed because they're not as interested in other things they were interested in. Well, heroin is one of those things. Or alcohol is one of those things. Or cocaine.

[Dr. Benjamin Bickman]

Exactly. In fact, that evidence is part of why I articulate the view the way I do.

[Jason DeFillippo]

I see.

[Dr. Benjamin Bickman]

I'm very familiar with the fact that it can be used to control addictions, and that's why I think it works the way it does. It makes you less interested in the foods you used to crave, but it also makes you less interested in the other things you used to enjoy.

[Jason DeFillippo]

Yeah, that's scary, man.

[Jordan Harbinger]

There's a lot more with insulin resistance.

[Jason DeFillippo]

That I'd love to cover. And we're going to blast through some of this stuff super fast, I think. But brain health was something I wasn't really expecting. Memory learning, insulin resistance in the brain. You even mentioned that Alzheimer's is sometimes called type 3 diabetes.

[Jordan Harbinger]

Can you speak to that a little bit?

[Dr. Benjamin Bickman]

Yeah, it Is, yeah, it's scary. But again, I would say there's some good news, because I think there's something empowering about realizing that so many of these scary chronic diseases have a metabolic core. There's a good news there because you can do something about metabolic health rather than just feeling helpless as you descend into cognitive decline. So the brain is no exception. As every tissue in the body suffers in insulin resistance, most people don't appreciate the fact that the brain, in order to get enough glucose to meet its energetic needs, it requires insulin to be working well. And so as the brain tissue becomes insulin resistant, now insulin comes and knocks on the doors of these neurons, asking the doors to open up so the glucose can come in to fuel the neuron. The doors don't open. There's no answer to insulin. And so as you improve insulin sensitivity, you enhance the brain's ability to get glucose. Now, there's another part to it, because as you also improve insulin sensitivity, your insulin levels come down. And as insulin comes down, the body starts burning more fat. And when the body burns more fat, it makes more of something called ketones. I've heard of this. And ketones are a very favorable fuel for the brain. The brain loves ketones, to put it in a silly way. In fact, if the brain has a preference for either glucose or ketones, it chooses ketones. If it has equal access to both from the blood, like 70% of its energy will start coming from ketones if the ketones are available, even when the ketones are at lower levels than the glucose, Just evidence of how much the brain prefers ketones. And when you give a cognitive decline, brain ketones, cognition improves. This has been now shown in multiple studies, human studies, where you take people with Alzheimer's disease, kick them into ketosis by, say, some exogenous ketones, some ketone supplements, rapidly get them into ketosis, have them repeat some cognitive tests, and they'll do better. Depression is one of the symptoms of Alzheimer's disease. It's not just memory, but it is all a manifestation of the brain starting to go hungry or the brain's starting to starve because it can't get enough glucose because of insulin resistance, and because people are spiking their insulin all the time, they're never making ketones. So you want to give the brain a shot at ketones.

[Jordan Harbinger]

I know that insulin also affects testosterone, sperm. There's erectile dysfunction ramifications here.

[Jason DeFillippo]

I will say when my A1C insulin resistance, triglycerides, cholesterol, all that stuff went down. And Got healthier. My hormones went way up on their own. And I read in your book this was a slap across the face for sure. Fat tissue, in a way, acts like an ovary in terms of aromatization and hormones.

[Jordan Harbinger]

Can you tell us what that means? Because that was. Man, if you told me that, I wouldn't have gotten fat in the first place.

[Jason DeFillippo]

I think.

[Dr. Benjamin Bickman]

Yeah, yeah, yeah. No, I mean, you definitely start thinking of like a scene from Seinfeld where like the man's ear or the bro where the guy is starting to store fat in a way that is less manly than it used to be. You actually expressed the perfect term here. Aromatization is the term to refer to the actions of an enzyme called aromatase. In aromatase, its purpose is to take testosterone and convert it into estradiol, which is the main estrogen. Estrogen is actually a little family of hormones. It's not one single hormone. But it's a little known fact that all estrogens were once testosterone in males and females. It's just ovaries do this more than testes do. One of the many, many unexpected effects of insulin is to inhibit aromatase. So as much as aromatization is attempting to convert testosterone into estradiol in a man, that's happening less than it is, of course, in female counterparts. But the bigger a man is getting, the bigger his fat cells are getting, the more the fat cells actually are expressing this enzyme, aromatase. This enzyme that you think is just one related to the gonads and sex hormone production in the testes and the ovaries absolutely begins to express itself at higher amounts and at ever greater activities in the fat cells of the person as they're getting fatter and fatter. This is important though, because it changes the perspective. We have a perspective which is that you're fat because you are low T. In fact, in most men, it's actually probably the exact opposite. You are low T because you have too much fat. And as you reduce your fat, you reduce the aromatization. And now your testes and all that hard earned testosterone they're making can remain as testosterone the way the testes intended it to be, without the fat cell taking it in and hijacking it and sending it out as estradiol, making you less manly, literally physically. So the more we cut back on fat cell mass, just fat mass, the more the testes are able to do the job they want to do, which is just fill the body with manly testosterone.

[Jason DeFillippo]

Interesting. Yeah, I love the way you put this. I think also erectile dysfunction. I. I get a lot of letters for our Feedback Friday segment instead of vice segment. I am quite disturbed by the number of 20, 25 year old men who have erectile dysfunction. And at first I was like, stop.

[Jordan Harbinger]

Watching so much porn.

[Jason DeFillippo]

You know, if you can't get it up for your girlfriend.

[Dr. Benjamin Bickman]

Amen.

[Jason DeFillippo]

But gross oversimplification probably. Look, I'm not going to say that's not a problem because it's definitely a problem.

[Dr. Benjamin Bickman]

Agreed, Agreed. No, I'm glad you noted that though, because I do think it's an important part of our culture where the more we indulge in this kind of behavior and assume it doesn't have any consequences, the more ignorant we are and the more we're hurting these young men. They need to know that the more you're exposing yourself to pornography, the harder it's going to get for you to have a normal sexual relationship with a real human.

[Jason DeFillippo]

100%. From a science perspective, we're not evolved to have a thousand sexual partners at any point in our life. Even, you know, Genghis Khan probably had his own issues as a result from that, right? But now, like a guy who's in high school and has a phone can access a new virtual sexual partner every single day.

[Dr. Benjamin Bickman]

Oh, no, Jordan. It is sobering. It makes me ache for these young men. I think about, at the risk of really sounding kind of weird, you know, growing up in a little farm town in Alberta, if you wanted to try to look at something inappropriate, you got.

[Jason DeFillippo]

To drive to town.

[Dr. Benjamin Bickman]

You literally couldn't find it. In our little town, we had one little gas station, no dirty little magazines were sold there.

[Jason DeFillippo]

Oh, I see.

[Dr. Benjamin Bickman]

You literally couldn't find it. And now the idea of a young man having it in his phone, man, these boys have to have a level of discipline that we didn't need in the early mid-80s. You know, when I would have been. Or even late 80s, when I would have been at my peak of curiosity of these kinds of things. Late 80s, I guess, early 90s. I'm so grateful I didn't have access to it.

[Jason DeFillippo]

It's a good point. I got access to Internet porn in what, like college?

[Jordan Harbinger]

And I was like, well, okay, but I also have a girlfriend. So, like, you know, I was going to choose the real one. But pornography aside, I get these letters.

[Jason DeFillippo]

From these guys that I think is part porn brain, right? They can't get it up without porn or something like that.

[Jordan Harbinger]

But also I also think that they have other physical issues.

[Jason DeFillippo]

And it never occurred to me that it could be the canary in the coal mine of insulin resistance because of the hormone thing. Can you speak to how that might affect our manhood?

[Dr. Benjamin Bickman]

Absolutely. So we already touched on the testosterone aspect, and that does matter. Testosterone is a relevant part of normal erectile function in fertility, in men. But we don't even need to go that far. We can actually just come right back to insulin resistance. It's a little known effect. One of insulin's additional effects is to act on the endothelium of blood vessels. The endothelium is the innermost lining of the blood vessel. So think about every blood vessel as a hose, a tube, and then the innermost layer is the endothelium. When insulin comes to the endothelium and binds its own receptors on the endothelium, it will stimulate the production of a molecule called nitric oxide. The nitric oxide will permeate through the blood vessel and tell the blood vessels to expand. And so that's a process called vasodilation. And it is an essential part of normal erectile function that insulin acts in those blood vessels to stimulate this increased blood flow to enable normal erectile function. If insulin isn't working well in insulin resistance, it isn't. Then those blood vessels stay constricted. In fact, this is so well known to be connected that there was a paper published by physicians maybe 10 or 15 years ago, and the title of it was really telling, where it said something like, is erectile dysfunction the earliest manifestation of insulin resistance in otherwise healthy men? I think that might literally be the title of the manuscript. Just suggesting that there's this incredibly relevant metabolic component to this hormone that we used to think of as only being relevant to blood sugar. No. It also regulates even something like erectile function. And then in women we have the balanced other side, which is polycystic ovary syndrome.

[Jordan Harbinger]

Is that pcos?

[Dr. Benjamin Bickman]

Pcos.

[Jason DeFillippo]

I keep hearing about this.

[Dr. Benjamin Bickman]

That's the most common form of infertility in women. And once again, it's a consequence of insulin resistance affecting the ovaries ability to produce sex hormones, which prevents her from having a normal ovulation cycle. And she has PCOS as a result. So both of the most common forms of infertility in men and women within their respective spheres still have the same metabolic core.

[Jordan Harbinger]

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[Jason DeFillippo]

You cover in the book air pollution and insulin resistance, aging, cancer, even lack of sleep making us insulin resistant or light exposure at night.

[Jordan Harbinger]

It's kind of like all the stuff we kind of knew we had to do for some reason for health generally.

[Jason DeFillippo]

Turns out to all kind of be connected to insulin. It's really wild.

[Dr. Benjamin Bickman]

That's exactly right. And this is why when I attempted, like I mentioned a little while ago, when I wanted to try to step out of academia and say, okay, do any of my ideas actually matter in the real world? Because if scientists are being honest with ourselves, publishing a peer reviewed paper in a scientific journal doesn't change the world. It doesn't do anything. No one will ever read it.

[Jordan Harbinger]

Spoiler alert.

[Jason DeFillippo]

Yeah, I was gonna say nobody's reading it.

[Dr. Benjamin Bickman]

Even my own dad isn't gonna read those papers. They're so irrelevant to the lay audience. So when I was first imagining what are my best ideas to articulate to help people be healthier, it was to just bring awareness to this one problem because of how common it is and because of how relevant it is with so many diseases coming from it. But just to be clear, I don't want someone to roll their eyes and think, okay, Ben believes that insulin resistance is the singular cause of all ills. No, there are other noxious stimuli that would play into chronic diseases that would totally be going around insulin resistance entirely. But if we know that so many of these chronic diseases do come from one single thing, that is empowering, like I've said, because then we can just address that one single thing, knowing that all these other things are gonna get better.

[Jason DeFillippo]

It was really sort of disgusting and eye opening. About the section of the book where you talked about how fat cells essentially.

[Jordan Harbinger]

Belch toxic stuff into your blood.

[Dr. Benjamin Bickman]

Yeah.

[Jason DeFillippo]

It's unfair. There's your body betraying you right there.

[Jordan Harbinger]

It's pumping out hormones you don't want. What was the other thing?

[Jason DeFillippo]

Cytokines or something?

[Dr. Benjamin Bickman]

Exactly.

[Jordan Harbinger]

What are those?

[Dr. Benjamin Bickman]

Yeah, so cytokines are basically hormones that promote inflammation.

[Jason DeFillippo]

Okay.

[Dr. Benjamin Bickman]

And when the fat cells getting really, really big. That's why I said the smaller fat cells are anti inflammatory, not only because they're not releasing these pro inflammatory hormones, but they are actually literally releasing hormones that dampen inflammation. So they're turning it in the opposite favorable direction. But the bigger the fat cell gets the more it is vomiting out these pro inflammatory hormones that we call cytokines.

[Jordan Harbinger]

Once you read books like this, you're.

[Jason DeFillippo]

Just like, oh my gosh, I had no idea how important it is to stain.

[Jordan Harbinger]

Like, you just think, like, you get.

[Jason DeFillippo]

A little bit fat, it's not good for you. Maybe it's a little bit of extra pressure on your heart, your organs. You're like, ah, I'll lose the weight later.

[Jordan Harbinger]

You don't realize that having extra fat is just. You have fueled up an entire system.

[Jason DeFillippo]

Of dangerous and unhealthy hormones, chemicals, byproducts.

[Jordan Harbinger]

That is just 247 chugging into your body. It's like you might as well have.

[Jason DeFillippo]

A drip feed of diesel fuel into your right arm. I mean, it's not quite that bad, obviously, but it's just really scary to think about because again, you kind of think like, oh, I'm a little overweight, you know, whatever, what's the big deal? I'll lose it later. You don't realize it's doing damage every minute that you're alive.

[Dr. Benjamin Bickman]

It is a drip. In fact, that term, it's so well identified in obesity that they call it subclinical chronic inflammation. It's subclinical because you're not coming in with some overt infection or you can't look at the person and say, boy, you have a lot of inflammation and yet all of those levels are higher than normal. And so it is chronic, it's subclinical because it's not obviously causing clinical consequences, although it is subtly contributing to a host of them.

[Jordan Harbinger]

Once you're a diabetic, is it possible to get off insulin ever or.

[Jason DeFillippo]

It probably depends on the type of diabetes, right? If your pancreas doesn't work, I mean.

[Dr. Benjamin Bickman]

That'S just 100% Depends. Yeah. So if it's type 1 diabetes, where you don't have the beta cells that make insulin, then you're on insulin for life. That doesn't mean there still isn't something to consider in all of this conversation. In fact, the same rule applies that if you are having to inject a lot of insulin to control all the carbs you're eating, the more you're injecting insulin, the more you have all the same consequences we've just been talking about, which is too much insulin driving, insulin resistance, and chronic disease. So the same rule applies. You just can never get off insulin entirely. You always need some. Now, in type 2 diabetes, that's absolutely the case, that you can fully reverse the disorder if it's true. Type 2 diabetes and not some form of type 1. To be clear, then, you are always making insulin. It's just a matter of you've demanded too much insulin from your body for too long and now you just need to recalibrate, if you will. We published a paper a couple years ago with a local clinic where we took 11 individuals with newly diagnosed type 2 diabetes. Every definition of type 2 diabetes they had, and within just 90 days of a low carbohydrate diet, and mind you, one that did not require them to count their calories. It was simply eat as much protein and fat as you want. Just keep your carbs to this level per day. Count the grams of carbs you eat so you don't have to be hungry. If you're hungry, eat. Just focus on proteins and fats. Within 90 days, every single one of these 11 people had reversed their type 2 diabetes by every clinical marker. There was no evidence of the disease whatsoever without ever having taken a single medication.

[Jordan Harbinger]

That's crazy.

[Jason DeFillippo]

I mean, sample size 11 is what people are going to say. So, yeah, we need more.

[Dr. Benjamin Bickman]

Yeah. So we published it as a case study, but you're seeing larger case reports and studies done, more actual clinical studies done by groups like Virta V I R T A. Virta Health has really been on the forefront of expanding this practice of looking at things like type 2 diabetes and saying this is a disease of you basically eating too much carbs.

[Jason DeFillippo]

Yeah.

[Dr. Benjamin Bickman]

And you just can't control your blood sugar anymore. And if you can't control your blood sugar, then let's just eat less of it.

[Jason DeFillippo]

Wow, this is really interesting. But it's great because what it means is you can take control of this and you might even be quite far gone down this road. You can still turn it back and reap all the benefits, especially to your brain and body. And again, it's part of your brain. Right. I think a lot of people might go, I don't care what I look like. And now it's like, oh, if there's a lot more going on than what you look like you're gonna end up with.

[Dr. Benjamin Bickman]

That's right.

[Jason DeFillippo]

Alzheimer's or. Yeah, Alzheimer's. Dementia, Other kinds of body issues that, you know, your penis isn't going to work. Guys are like, wait a minute.

[Dr. Benjamin Bickman]

Yeah, I want. I want that thing to work.

[Jason DeFillippo]

Yeah.

[Jordan Harbinger]

Like I thought. Okay, I'm overweight. At least I can take care of myself. Not for long there, buddy. Not for long.

[Jason DeFillippo]

You can't.

[Jordan Harbinger]

It's not going to work. It's not going to work at all.

[Jason DeFillippo]

Yeah.

[Jordan Harbinger]

So get things going on here. Wow, this is quite powerful. I mean, just restricting your carb intake.

[Jason DeFillippo]

Is just from somebody who went on a major diet a few years ago. Like I told you before, if I.

[Jordan Harbinger]

Only had to count my carbs, but.

[Jason DeFillippo]

I could eat as much protein and fat as I wanted. That's an amazing diet. That's really not hard to do.

[Jordan Harbinger]

It works because chiefly the calorie restriction is the issue.

[Jason DeFillippo]

Right. That's the part that makes you hungry.

[Jordan Harbinger]

But if you can just eat chicken and you're good, that's amazing.

[Dr. Benjamin Bickman]

Or even hamburger.

[Jason DeFillippo]

Yeah.

[Dr. Benjamin Bickman]

Make some hamburger patties and eat those hamburger patties.

[Jason DeFillippo]

That's a diet that literally, I think anybody could follow.

[Dr. Benjamin Bickman]

The problem being how addicted to carbs are you?

[Jason DeFillippo]

Yeah, right.

[Dr. Benjamin Bickman]

The concept is so simple, but the implementation might not be. There are some people who just with that knowledge are able to say, okay, I'm in, I'm committed.

[Jason DeFillippo]

That was me.

[Dr. Benjamin Bickman]

Yeah, you might be one of those people. But there are a lot of people. We know where those carbs are calling. It's like a little siren call every evening, tempting them to jump off the ship and drown themselves in like five bowls of cereal.

[Jason DeFillippo]

I mean, that's when you got to get out the atomic habits. James. Clear stuff. Right. And like, not have it in the house and like, make it so that your doordash requires you to log in every time you want to order something. And you know, all that, all that stuff to get. Get rid of the carb temptations. Have a locking cupboard that if your wife wants to eat Cheetos, she can, but you can't get in there.

[Dr. Benjamin Bickman]

Yeah. But also recruit help. You know, if you can. Mind you, sometimes the people we love end up sabotaging our efforts because they see you making a change that they don't want to make yet or they're not prepared to. But insofar as you can, like people listening who have a goal here, recruit help. Ask your friend or family loved one express some of these concerns and say, can you follow up with me? I've mentioned now a couple times having bowls of cereal that is like crack cocaine to me. In the evening, I will go through this pattern of like an addict where I will say, well, I'm just going to have one little bowl. This is so me knowing that I'm not going to stop at one bowl. If I could stop at one bowl, that would be fine, but I don't. I will not stop eating those frosted mini wheats until I have Them coming out my nose. And so I've told my wife over the years, if you see me go to the pantry. But again, we don't buy it very often because I know I can't control myself. But if I'll tell her, cheryl, if you see me going to the pantry, you stop me. I'm going to be a little tiffy about it. I'm going to be a little angry. That's right. But I mean, never mean, but don't care. You never care about how I feel about anything. Don't care now. Don't care. Now you're in charge. Yeah. You just tell me to stop. And it has helped.

[Jason DeFillippo]

Man, I'm the same way. If I. I'll be done eating, I'll be at my calorie thing because I still count the calories. I'm not the guy who can eyeball the food, even though it's just the numbers higher now.

[Jordan Harbinger]

And I'm like, oh, there's Captain Crunch. Yep, in the pantry. Oh, man, I want a handful of that. So I take a handful and I'm.

[Jason DeFillippo]

Like, that's kind of a small handful. Let me get a bigger one. And then I.

[Dr. Benjamin Bickman]

Well. And I need a little milk to help wash it down.

[Jordan Harbinger]

And you can't put that in your hand. So you put that in the bowl and you're like, that doesn't look like very much.

[Jason DeFillippo]

I could probably put another handful in there and then a little bit more milk.

[Jordan Harbinger]

And then suddenly I'm eating a whole.

[Jason DeFillippo]

Bowl of Captain Crunch at 9:30pm and.

[Jordan Harbinger]

You'Re just like, how did I get here?

[Dr. Benjamin Bickman]

I know, I know. Like, that's what I mean. That's why I say it's like a true addiction where, you know, you don't want to do it. But this is another reason why I rage against this mantra, moderation in all things. And I think that's the thing that the dietitian likes to say, because they don't want to say that some foods are worse than others. For some reason. I don't know what's in their brains that make them not able to admit that. But moderation in all things is one of the most horrific ideologies when it comes to addictive habits. Would we ever tell an alcoholic friend, if we're going out for drinks, hey, just we're going to go out for drinks. Why are you drinking milk? You know, I say that as a Mormon boy who does drink milk when I go out with buddies. And we'll say, hey, why are you drinking? Just come have A beer? Well, I can't. I'm an alcoholic. Well, then just have one.

[Jason DeFillippo]

Yeah.

[Dr. Benjamin Bickman]

How stupid is that? So St. Augustine. Funny for a Mormon boy like me, to quote a Catholic saint, St. Augustine said, which is brilliant and beautifully articulated. Abstinence is easier than perfect moderation for some of us. We need to acknowledge I'm an addict to these carbs. And so it's easier for me to never even start eating than it is to stop eating. So just don't even start.

[Jason DeFillippo]

I routinely say, why did you buy the big box of this? For the kids? And my wife's like, for the kids, huh? And I'm like, I don't need you enabling me. Yeah.

[Dr. Benjamin Bickman]

No. Your dynamic might be the same as mine.

[Jason DeFillippo]

Yeah.

[Dr. Benjamin Bickman]

My wife and I, I can have a pint of Ben and Jerry's or a pint of Haagen Dazs. One for me and one for my wife. She has this alien, like, ability to pop the lid off and daintily eat five or six bites, put the lid on and put it in the freezer.

[Jason DeFillippo]

Can't relate.

[Dr. Benjamin Bickman]

Yeah, I can't relate because not only am I going to go to the bottom of my pint, but I'm going to be wondering when she looks away so I can go finish hers, too.

[Jason DeFillippo]

That's right.

[Jordan Harbinger]

I want to just.

[Jason DeFillippo]

I want to taste a couple of those, too, on the other side. Yeah, exactly.

[Dr. Benjamin Bickman]

Yes.

[Jordan Harbinger]

So folks obviously should talk to their.

[Jason DeFillippo]

Doctor before they go on diets of any kind. Probably. But, yes, lower. Cut out the carbs and stop buying them and things like that, if you can. And see if your insulin, your fasting insulin levels change. That's the metric we're looking at in the blood.

[Dr. Benjamin Bickman]

Absolutely.

[Jordan Harbinger]

What about artificial sweeteners? Like, if I'm drinking a Diet Coke.

[Jason DeFillippo]

Is this spiking my insulin and is that bad?

[Dr. Benjamin Bickman]

Yeah, Good question. No, no. So it depends on the sweetener. But with Diet Coke, very explicitly, aspartame does not increase insulin. And so drinking a diet soda and even. But nowadays, more and more of the sodas have sucralose in them, too. So if it's a zero drink rather than just diet, then it has some aspartame and sucralose. I personally don't like the taste of sucralose. It's a little too sweet for me.

[Jason DeFillippo]

Yeah, same.

[Dr. Benjamin Bickman]

So if I want an indulgence, and I absolutely sometimes do, I will drink a diet Dr. Pepper. And there was no effect on a CGM or on insulin whatsoever. Now, that's not to say all Sweeteners are benign. Stevia is maybe the best one most consistently. As long as stevia has been around, there's like never been a single negative paper published about it. Aspartame's fine, stevia is fine. Monk fruit extract is fine, Erythritol is fine. But then some of the other alls do have a mild insulin effect, which can have consequences where it might make you a little hungrier after. So my view on sweeteners is if a person eats something that has been sweetened with a sweetener, and if it makes you a little hungry after, then it's one you should probably avoid because it probably is spiking your insulin. And mind you, some people can have a different response based on their microbiome. The microbiome actually can metabolize some of these sweeteners in different ways. So it gets more complicated than most people want to think. But, you know, I should have actually mentioned a sweetener. Allulose. Allulose is one that, far from making you feel hungry, increases GLP1 significantly. RX Sugar, for example, makes a bunch of allulose products. You're going to feel more full. So that's something I've used in the past. In the evenings, when I have some cravings, I'll eat a little sweetened allulose bar or something and it'll be pretty effective for appetite control. So not all sweeteners are created equal.

[Jason DeFillippo]

You might have to send me a link to your favorite allulose sweetened bar, because I've never heard of that. I want to try that and I'll put it in the show notes because I think people are going, wait, there's a bar I can eat that will make me not want to eat more stuff after that. That's pretty useful. What's one habit you changed after seeing your own data?

[Dr. Benjamin Bickman]

That's a great question. In fact, data is the right way to frame it because I did some of these changes I made based on data that I saw from wearables that I had on monitoring my sleep and at the same time monitoring my blood sugar levels with a continuous glucose monitor. Maybe the one habit that I've changed that has helped me the most overall, including and most especially my sleep habits. And I've long been a terrible sleeper, has been not spiking my blood glucose before I go to bed. Actually, I would wonder why I would be lying there in bed. My heart would be racing, it'd be beating hard and I'd be hot and like, I'd sweat so much I'd be so hot. And I didn't know that I was going to bed hyperglycemic every night. And hyperglycemia actually stimulates the sympathetic nervous system. That's the aspect of our nervous system that gets us ready to run and engage in something physical. Well, that's a terrible time to activate your sympathetic nervous system when you're trying to sleep. And so the one habit I changed the most, based on data, my own, was really avoiding glucose spiking foods in the evening. Easier said than done. But I shifted to other habits.

[Jason DeFillippo]

Yeah, Mr. Cereal Bowl.

[Jordan Harbinger]

Exactly.

[Jason DeFillippo]

That is easier said than done. Yep. It's funny.

[Jordan Harbinger]

What's one thing you changed?

[Jason DeFillippo]

Oh, stopped eating carbs in the evening.

[Jordan Harbinger]

Didn't we just talk about how you started?

[Jason DeFillippo]

You eat cereal every night.

[Dr. Benjamin Bickman]

Yeah.

[Jason DeFillippo]

That's good to know, though.

[Dr. Benjamin Bickman]

But that helped me with my motivation, honestly. Because when I started thinking about the lingering consequences of my poor sleep, it became a little more stark. Where before it would just be, hey, Ben, you're losing your six pack. You're going to get a little chubby. Well, that's so subtle that I could justify it. But when I really acknowledged now this is making me really chronically sleep deprived and I feel miserable all the time, that gave me a little extra push to actually help me make some differences.

[Jason DeFillippo]

I'll wrap with this. If you could allocate, let's say, $100 million of NIH money tomorrow, what study would you run?

[Dr. Benjamin Bickman]

That's an awesome question. I would do the opposite of all of these weight loss studies. So there's still a very ongoing raging debate about the nature of obesity, where some people will say, it's just purely calories, some people will say, no, it's just purely hormones, namely insulin. And my view is that it's actually a little bit of both, that a fat cell needs to be told to get fat, which is what insulin does, and it cannot without that signal. But at the same time, it has to have those calories to fuel that growth, so you can't have it either way. The problem is all the studies that have been done to try to answer that question. Is it a calorie problem? Is it a hormone problem? Have been weight loss studies, which introduces a tremendously relevant confounding variable, which is when you take the average person and say you're going to go from your standard American diet to this low fat diet, high carb, it's actually still fewer carbs than it was compared to the standard American diet. So in both diets, you actually have both lower calorie and lower insulin. Because even though this one over here is low fat but high carb, it's still fewer carbs than it was before because you're making them eat so much less. So you've never been able to answer the question on any of these weight loss studies, is it a calorie problem or is it an insulin problem? So to answer the question better, we actually have to do a weight gain problem, which is try to make people fat and have them on two different diets. Say, hey, you're going on a high carb version of this high calorie diet. You're going on a ketogenic version, a low carb, high fat version, but it's high calorie, and we're going to see which one makes people fatter. That then would answer the question much more definitively, and I would argue much more convincingly of what is it that makes us fat? Because trying to answer what makes us fat by doing weight loss studies is the wrong way to answer it, and it's going to continue to lead to confusion. So we need to actually make people fat and see which one is harder to get fatter on.

[Jordan Harbinger]

That's a good point. I hadn't even thought about that.

[Jason DeFillippo]

Wow.

[Jordan Harbinger]

It seems like somebody would love to.

[Jason DeFillippo]

Fund something like that. I don't know how the grant process works.

[Dr. Benjamin Bickman]

Oh, man, Jordan, it's so frustrating to get grants. It's maybe the one part about being a professor. I hate them. As a scientist, I hate the most.

[Jason DeFillippo]

Yeah, I'm sure you're not alone.

[Dr. Benjamin Bickman]

It is so difficult.

[Jordan Harbinger]

It just seems like if we could figure out what. But don't drug companies want to know what makes people fat? Don't exercise companies want to know what makes people.

[Jason DeFillippo]

It seems like a lot of people would be able to use these results.

[Dr. Benjamin Bickman]

Well, yeah, but you say a drug company. But the problem is there's no money to be made. If it is just a matter of control your carbs.

[Jason DeFillippo]

I see.

[Dr. Benjamin Bickman]

I would argue that the fact that there's nothing to patent is why these kinds of studies have not been done.

[Jason DeFillippo]

That totally makes sense. You're right. If the answer is, hey, eat less junk, they're going to go, well, wait a minute. I can't put a label on that. I can't sell that to your insurance company. Yeah, you're right. You're kind of stuck. You're gonna have to raise that money yourself.

[Jordan Harbinger]

The good news is it probably won't cost $100 million.

[Dr. Benjamin Bickman]

Oh, it would be less.

[Jason DeFillippo]

Yeah.

[Dr. Benjamin Bickman]

Yeah, but more than I can fund at the moment. Someday.

[Jason DeFillippo]

Yeah, man, you gotta call those Walmart Mormons, see if they can cut you a check.

[Dr. Benjamin Bickman]

You gotta start rallying the big BYU alumni base.

[Jordan Harbinger]

That's right. Dr. Beckman, thank you so much. This is fascinating. I, you know, whenever I look at.

[Jason DeFillippo]

The nutrition stuff, I'm always like, oh.

[Jordan Harbinger]

Am I gonna be interested in this nutrition thing?

[Jason DeFillippo]

And then it's always just endlessly fascinating. I really enjoyed this conversation, man. Thank you so much.

[Dr. Benjamin Bickman]

I did, too. This was great. Yeah, thanks so much for having me on.

[Jordan Harbinger]

What happens when the only way to survive is to lie so well? You forget who you really are? FBI veteran Scott Payne went undercover with one of the most dangerous biker gangs in the country and almost didn't make it out.

[Scott Payne]

This is the way I was trained, and this is what I think. Anytime you are something that you're not pretending to be, something that's opposite of you for a long period of time, especially in deep cover, generally one or two things is going to happen. You're either going to slip up and they're going to catch you, or you're going to become it. Because there's so many horror stories and undercovers, it sucks that the same mistakes are being made today that were being made in the 80s. You got a small department, you got somebody that's running the undercover, but that person is always also the case agent who is going to get promoted if the case succeeds. I'm not saying people are going to do the wrong thing. It's just a bad foundation. I guess people is kind of my business. Even as an investigator, at the end of the day, you need to be able to sit down with somebody and have a conversation with them and gather intelligence, get information. Because if all else fails and computers shut down and phones, that's great. It's all good stuff. But it's all human intelligence, and you just need to be able to talk to people. You got to be believable. And this is where a lot of people think about undercover. And when I'm out training and speaking, I mean, I'll ask, what do you think undercover is? Some people say acting. I go, okay, what else you think it is? Lying. Pretend to be something you're not. The true definition of undercover work is you're forming relationships that you're most likely going to betray. That sucks if you look at it that way. But you need to be able to figure out a way you're going to do it and rationalize it in your mind so it doesn't have an adverse impact on you.

[Jordan Harbinger]

Go inside Basement strip searches A brotherhood built on betrayal and the psychological damage that still lingers on. Episode 1120 of the Jordan Harbinger show.

[Jason DeFillippo]

Man, there was a lot we didn't even get to.

[Jordan Harbinger]

It's really more than just how fat.

[Jason DeFillippo]

You are, it's how you store it.

[Jordan Harbinger]

How do we know if we have that DEXA scan? I suppose, you know, is it between my organs?

[Jason DeFillippo]

Is it outside? Is it subcutaneous?

[Jordan Harbinger]

Pants don't fit. Can't see penis without mirror. I mean, good rules of thumb, but maybe not the best heuristic I've actually.

[Jason DeFillippo]

Had people ask before if I had diabetes because I am peeing constantly. I know some of you can relate. It turns out I'm just really well hydrated. But if you also are not well hydrated and you pee constantly, check that.

[Jordan Harbinger]

Insulin Resistance the book goes over a.

[Jason DeFillippo]

Lot of other topics related to insulin resistance. Autophagy, which is cell death, evolutionary context.

[Jordan Harbinger]

Early onset puberty, obesity, cancer, aging, air pollution, even lack of sleep can make us insulin resistant. Basically, a lot of things that make us unwell at first at least, lead to insulin resistance.

[Jason DeFillippo]

It's really quite fascinating and alarming.

[Jordan Harbinger]

So if you are insulin resistant, if that's what your blood work shows, I.

[Jason DeFillippo]

Highly recommend getting that under control. Because man, the downstream effects from that are just as you heard on the show, horrible.

[Jordan Harbinger]

Lethal. Insert adjective here.

[Jason DeFillippo]

Really not something you want to face.

[Jordan Harbinger]

All things Benjamin Bickman will be in the show. Notes on the Website Advertisers, Deals Discount Codes Ways to support this podcast [e-mail] deals please consider supporting those who support the show. Also our newsletter Very engaged you all are with this.

[Jason DeFillippo]

That was a weird way of Yoda way of saying it.

[Jordan Harbinger]

Anyway, the idea is to give you something specific and practical that'll have an immediate impact on your decisions, your psychology, and your relationships.

[Jason DeFillippo]

In under two minutes, we make it.

[Jordan Harbinger]

A good fast read.

[Jason DeFillippo]

It's out almost every Wednesday and it's a great companion to the show. Jordanharbinger.com news is where you can find it. Don't forget about six minute networking as well.

[Jordan Harbinger]

Over at sixminutenetworking.com I'm ordanharbinger on Twitter and Instagram.

[Jason DeFillippo]

You can also connect with me on.

[Jordan Harbinger]

LinkedIn in this show. It's created in association with podcast one. My team is Jen Harbinger, Jace Sanderson, Robert Fogarty, Tata Sidlowskis, Ian Baird, and Gabriel Mizrahi. Remember, we rise by lifting others the fee for the show is to share it with friends. When you find something useful or interesting, the greatest compliment you can give us is to share the show with those you care about. If you know somebody who's interested in health, maybe is worried about their insulin, maybe needs to get in better shape, definitely share this episode with them. In the meantime, I hope you apply what you hear on the show so you can live what you learn and.

[Jason DeFillippo]

We'Ll see you next time.

[Jordan Harbinger]

This episode is also sponsored in part by Progressive. You ever think about switching insurance companies to see if you could save some cash? Progressive makes it easy. Just drop in some details about yourself and see if you're eligible to save some money when you bundle your home and auto policies. The process only takes minutes and it could mean hundreds more in your pocket. Visit progressive.com after this episode to see if you could save Progressive Casualty Insurance Company and affiliates. Potential savings will vary. Not available in all states.

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[Dr. Benjamin Bickman]

Thanks.

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