
Hosted by Kris Gethin · EN

What if optimizing your health isn't just about training, nutrition, supplements, and sleep—but about the trillions of microorganisms living within and around you? In this episode, Kris sits down with Dr. Zach Bush to explore the microbiome and its potential influence on everything from digestion and brain function to hormones, athletic performance, recovery, and longevity. Dr. Bush shares how his career evolved from conventional endocrinology into microbiome and environmental health research, and why he believes many of the health challenges we face today cannot be separated from the health of our soil, food systems, and environment. They discuss the impact of modern agriculture, antibiotics, glyphosate, declining nutrient density, and environmental exposures on the microbiome, along with practical ways to support greater microbial diversity and resilience. The conversation also explores the gut-brain axis, intermittent fasting, regenerative agriculture, and Dr. Bush's work developing Restore, including his theory that microbial communication may play a much larger role in human health and longevity than we currently understand. In This Episode: Why Dr. Zach Bush left conventional endocrinology to study the microbiome How soil health and modern agriculture may influence human health and nutrition What antibiotics, glyphosate, and environmental exposures can do to microbial diversity The gut-brain connection and its relationship with mood, cognition, hormones, and neurological health Why gut integrity and microbial diversity may matter for athletic performance and recovery How modern farming practices have changed the nutritional landscape of our food Intermittent fasting and the potential benefits of giving the gut time to repair Why different people can respond very differently to the same foods and diets The connection between our environment and microbiome resilience Regenerative agriculture and rebuilding healthier soil ecosystems The science and thinking behind Restore and microbial communication How supporting the microbiome could influence resilience, healthspan, and longevity Timestamps: 00:00 – Why microbiome health matters for fitness, health, and longevity 02:12 – Dr. Zach Bush's journey from endocrinology to microbiome research 05:12 – How chemicals, pollutants, and our environment may influence human health 06:57 – The gut-brain axis: microbiome, mental health, and neurochemistry 09:36 – Has modern agriculture changed the nutrient density of our food? 12:24 – Antibiotics, glyphosate, microbiome diversity, and gut integrity 15:41 – Inflammation, gut barrier function, and athletic performance 18:36 – What animal agriculture can teach us about the microbiome and performance 20:27 – Gut health, testosterone, growth hormone, and neurochemicals 22:33 – Organic food, dietary diversity, and finding what works for the individual 26:06 – Intermittent fasting, gut repair, and hormonal health 29:24 – Why there is no universal "perfect diet" for the microbiome 33:03 – How your environment shapes microbiome resilience 36:25 – Supporting microbial diversity through food, lifestyle, and environment 41:15 – Microbial communication and its potential role in chronic disease 45:50 – Soil health, regenerative agriculture, and the future of human health 50:29 – Restore: the formulation, research, and theory behind it 56:28 – Cellular repair, resilience, and longevity 1:03:25 – "Cellular Wi-Fi": understanding microbial communication 1:08:00 – Travel, environmental exposures, and supporting the microbiome 1:10:50 – The bigger picture: restoring the health of our soil, microbiome, and future generations Resources & Links: PLEASE NOTE: Restore is now Ion* Gut Support Glyphosate / Roundup Information Connect with Dr. Zach Bush: Website Instagram Thank you to our sponsors: Biostack Labs NovaPrime Labs

Bryan Johnson's recent autoimmune diagnosis has sparked an important conversation throughout the biohacking community. In this episode, Kris Gethin explores what this moment means—not as a criticism of Bryan's dedication, but as an opportunity to ask bigger questions about health, longevity, and the limits of optimization. Kris discusses the difference between collecting health data and creating true health, why modern lifestyles often disconnect us from our biological foundations, and how factors like sunlight, movement, grounding, nutrition, and resilience may matter more than endlessly stacking interventions. This episode is a reminder that while technology can be an incredible tool, it should support our biology—not replace it. Ultimately, longevity may depend less on eliminating every risk and more on working with the way humans were designed to live. In This Episode What Bryan Johnson's autoimmune diagnosis means for the future of biohacking Why more health data doesn't always translate to better health The difference between optimizing biomarkers and optimizing human biology How modern indoor living affects health, resilience, and longevity Why sunlight, movement, grounding, and nature remain foundational Animal-based nutrition vs. plant-based diets for performance and healthy aging The importance of preserving muscle as we age EMF exposure: what we know, what we don't, and practical ways to reduce it Why resilience—not eliminating every challenge—is essential for long-term health The role of humility, curiosity, and evolving with new scientific evidence Timestamps 00:00 – Bryan Johnson's autoimmune diagnosis and why it matters 00:23 – The dedication behind modern biohacking 00:50 – Are we pursuing optimization at the expense of biology? 01:17 – Did lifestyle cause the autoimmune condition? 01:46 – Respecting pioneers while continuing to ask questions 02:14 – The difference between tracking health and creating health 02:42 – When technology becomes overcomplication 03:12 – The environment humans were designed for 03:41 – Using technology to support biology—not replace it 04:10 – Why sunlight, movement, and circadian rhythms matter 04:36 – The health costs of modern indoor living 05:03 – Building resilience instead of avoiding every challenge 05:33 – Adaptation as a cornerstone of longevity 05:59 – Animal protein vs. plant-based nutrition 06:27 – Nutrient density and healthy aging 06:55 – Why muscle is one of the greatest predictors of longevity 07:23 – Respecting Bryan Johnson's discipline and consistency 07:52 – The physiological case for animal-based nutrition 08:21 – Personal lessons on maintaining muscle with age 08:50 – Sunlight's role in hormones and circadian health 09:17 – Grounding and reconnecting with nature 09:46 – What we currently know about EMF exposure 10:12 – Practical ways to reduce unnecessary EMF exposure 10:42 – Redefining optimization through simplicity 11:11 – Why resilience is built—not manufactured 11:38 – The downside of chasing certainty through endless interventions 12:06 – The tendency to overcomplicate health 12:36 – How nature helps regulate the nervous system 13:02 – Reinforcing biology with technology 13:30 – The importance of natural environmental inputs 13:56 – The complexity of human biology 14:23 – Balancing risk with resilience 14:49 – Letting go of outdated beliefs 15:19 – How reputation and business can influence health messaging 15:48 – The importance of transparency and humility in science 16:14 – Evolving as evidence evolves 16:40 – Staying curious instead of becoming attached to methods 17:06 – The biggest lesson from Bryan Johnson's journey 17:35 – Why wealth and technology can't override biology 17:59 – Understanding nature instead of trying to conquer it 18:27 – Measuring success beyond biomarkers 18:52 – Asking better questions about health and longevity 19:23 – The future of biohacking: science, humility, and biological principles 19:52 – Building health on timeless foundations 20:21 – Closing thoughts Resources Mentioned Bryan Johnson's longevity and biohacking journey Bahe Grounding Shoes - use code KRIS15 to save 15% off Blushield.com Practical EMF mitigation strategies - use code KRIS for 10% off Connect with Kris Gethin Website Instagram X (Twitter) Youtube Tik Tok

Kris Gethin shares insights on fitness, biohacking, the challenges of content creation, and personal experiences from recent travels. This episode offers practical advice on training, nutrition, and navigating the complex world of health supplements and social media. Chapters 00:00 Introduction and studio setup 00:37 New energy drink and market challenges 01:18 Kris Gethin's approach to cardio and the Carol Bike 02:13 Research-backed benefits of Rehit protocol 03:38 Recent travels and seminars in India and UK 05:06 Family, work, and managing distractions 06:27 Dealing with Airbnb and property management 08:22 Workout routines during travel and discipline 09:24 Sleep vs. workout dilemma 10:49 Supplements for mental and physical performance 12:15 Handling fatigue and overtraining 13:37 Client accountability and motivation 14:46 Formulating personalized training plans 17:08 Body composition and fat loss strategies 19:53 Muscle building and body transformation 22:45 Challenges in supplement industry and product launches 24:41 Community building and education in biohacking 27:59 The importance of medical guidance and diagnostics 30:48 The impact of GLP-1 and lifestyle on health 33:39 The future of biohacking and longevity 36:57 Reflections on personal growth and industry challenges 44:44 New product developments and success stories 50:33 Final thoughts and upcoming projects Resources Nova Prime Labs - Peptides and Oral Bioregulators - https://novaprimalabs.com/ Biohackedaf.com - Community and Education Platform - https://biohacktaf.com/ Unmatched Supps - Sports Performance Supplements - https://unmatchedsupps.com Biostack Labs - Anti-aging and Longevity Supplements - https://biostacklabs.com

Understanding Oral Bioregulators: A Deep Dive In the world of health supplements, oral bioregulators are emerging as a significant topic of discussion, yet many remain unaware of their potential benefits and applications. In this episode, we'll explore what oral bioregulators are, how they function, and why they might be a game-changer in your health regimen. Chapters 00:00 Introduction and Context 02:26 Understanding Oral Peptide Bioregulators 09:25 Prostate Health and Bioregulators 13:34 Eye Health and Retinal Support 16:53 Kidney Function and Bioregulators 20:33 Liver Health and Detoxification 23:58 Cartilage Repair and Joint Health 24:50 Understanding SLU PP332 and Its Role 27:35 Quality and Sourcing of Bioregulators 28:58 Conclusion and Community Engagement Thank you to our sponsors: NovaPrime Labs www.novaprimelabs.com Biostack Labs www.biostacklabs.com Unmatched Supps www.unmatchedsupps.com

Biohacking has become the new status symbol. Everyone wants the chamber, the wearable, the peptide, the IV, the stem cells, the red light, and the expensive recovery tool. But there is a problem most people do not want to admit: the body may not respond to the expensive stuff if the foundation underneath it is weak. In this episode, I'm talking about the part of biohacking that does not look impressive online but changes how well everything else works. The part people skip before they spend thousands trying to fix their energy, sleep, recovery, hormones, body composition, inflammation, focus, and health span. It is not that advanced tools have no place. It is that your body has to be in a position to use them. I also share where advanced biohacking tools fit into my own routine, and why I think the order matters. If you have been chasing the newest longevity tool, tracking every metric, or wondering why you still do not feel the way you want to feel, this episode will make you rethink what actually makes biohacking work. What's Discussed: (00:04) Why the most expensive biohacks can still miss the real problem. (02:26) What people are really trying to buy when they chase better energy, sleep, recovery, and health span. (04:48) The lifestyle gaps no device, compound, clinic, or recovery tool can cover for you. (06:31) The free layer of biohacking most people underestimate. (08:08) Why the body needs the right foundation before advanced tools work well. (15:30) The fat-loss and health-span mistake that can leave people lighter but weaker. (23:42) How to use data, recovery tech, supplements, and advanced tools without turning them into expensive entertainment. If you want my free book, A Guide to Biohacking, leave an honest review on the platform where you listen to this podcast, then email a screenshot to info@krisgethin.com. Find more from Kris Gethin: Website: krisgethin.com/ Instagram: @krisgethin/ YouTube: youtube.com/krisgethin 2 Shred: unmatchedsupps.com/products/2shred Resources Referenced in This Episode: Red Light Therapy Brand: Red Light Rising Link: redlightrising.co.uk/ Code: GETHIN5 Lumaflex, click here and use Code: KRISGETHIN (10% off) Collagen BPC-157 TB-500 GHK-Cu KPV Cartilax Sigma / Bio Cartilage / Nova Cartilage Vesugen

Kris Gethin explores the use of melanotan, a peptide that stimulates melanin production, as a healthier alternative to traditional tanning methods. He discusses its benefits for skin health, appearance, confidence, and long-term skin protection, emphasizing research perspectives and safety considerations. Chapters 00:00 Introduction and Kris Gethin's Personal Tanning Experience 01:22 What is Melanotan and Its Historical Use 03:41 Visual Benefits of a Darker Skin Tone 05:38 Health Risks of Tanning Beds and Overexposure 07:32 Pre-Holiday Skin Preparation with Melanotan 08:52 Reduced Sun Exposure and Skin Aging 10:12 Confidence and Aesthetic Benefits of Tanning 11:39 Research and Protective Aspects of Melanotan 13:03 Supporting Skin Health from Within 14:25 Long-Term Skin Protection and Aging Prevention 15:49 Building a Complete Skin Care Strategy Resources Preferred peptides: www.novaprimelabs.com Join the Biohacked AF Community - https://www.biohackedaf.com Melanotan Research Overview - https://pubmed.ncbi.nlm.nih.gov/ To enquire about 1 on 1 coaching with Kris email info@krisgethin.com

Discover the science behind Tesamorelin, a research peptide targeting visceral fat and promoting health span. Kris Gethin breaks down its mechanisms, research findings, and implications for fat distribution and longevity. Tesamorelin is a synthetic analog of growth hormone release hormone (GHRH), stimulating the pituitary to release endogenous growth hormone rather than supplying synthetic GH. It primarily targets deep visceral fat, especially around organs, instead of just superficial subcutaneous fat. Visceral fat is linked to metabolic diseases, inflammation, insulin resistance, and overall aging; reducing it can extend health span. Research shows Tesamorelin reduces visceral fat by approximately 14-18% over 26 weeks without significant weight change. Unlike appetite suppressants like GLP-1 agents, Tesamorelin is considered weight-neutral, aiming for fat redistribution rather than broad weight loss. The effects on body composition include improved fat distribution, preservation of lean mass, and healthier metabolic markers. It can influence glucose tolerance and may cause fluid retention, joint pain, or injection site reactions, especially in older or metabolic-compromised individuals. Optimizing lifestyle factors such as sleep, nutrition, and stress management is crucial, as environment impacts visceral fat accumulation. Measuring waist circumference, visceral fat via imaging, blood markers, and metabolic health indicators are essential for tracking progress. Use of peptides like Tesamorelin should be under medical supervision within a broader health and lifestyle strategy. Timestamps: 00:00 - Introduction to Kris Gethin and peptide content channels 00:27 - What is Tesamorelin and its clinical relevance 00:56 - Mechanism: GHRH analog stimulating growth hormone release 01:23 - Differentiating Tesamorelin from other peptides and its origin 01:50 - Impact on visceral and liver fat, and fat loss models 02:20 - Growth hormone axis and visceral fat interaction 02:44 - Education disclaimer and medical considerations 03:14 - Historical context: HIV-related lipodystrophy and fat redistribution 04:12 - Visceral vs subcutaneous fat differences 04:42 - Psychological and health impacts of visceral fat 05:10 - How Tesamorelin targets internal fat and body composition 05:37 - Fat loss measurement—imaging and metabolic markers 06:06 - Clinical trial outcomes: visceral fat reduction statistics 06:33 - Fat redistribution versus scale weight changes 07:00 - Growth hormone effects on adipose tissue and fat mobilization 07:29 - Localized fat loss and research evidence 07:58 - Impact on organs around visceral fat 08:24 - Clinical trial insights on visceral fat change over 26 weeks 08:53 - Quantitative results: visceral fat reduction percentages 09:21 - Fat loss success indicators: visceral fat, waist size, metabolics 09:49 - Why weight-neutral interventions are vital for health span 10:18 - Visceral fat's role in metabolic aging and liver health 10:45 - External factors influencing visceral fat and lifestyle importance 11:15 - Liver fat, insulin resistance, and metabolic health 11:45 - Impact on HIV-associated liver issues and relevance to non-HIV populations 12:14 - Liver fat's role in glucose regulation and overall health 12:42 - The importance of measuring internal fat and metabolic health 13:10 - How lifestyle interacts with peptide effects and fat storage 13:38 - The complex role of growth hormone and IGF-1 in body health 14:06 - Risks, side effects, and precautions with Tesamorelin 14:36 - The importance of medical oversight and blood work monitoring 15:06 - Peptides as part of broader lifestyle strategies 15:35 - Influence of environment and lifestyle on visceral fat 16:04 - The significance of fat distribution for health and appearance 16:33 - Misconceptions: fat loss vs fat redistribution and muscle preservation 17:02 - The balance of growth hormone signaling and metabolic risks 17:31 - Regulating GH pathways for optimal health outcomes 18:00 - Side effects: fluid retention, joint pain, sleep issues 18:29 - Medical considerations: conditions requiring caution 18:58 - The impact of growth hormone on glucose metabolism 19:27 - Reversibility: why maintaining lifestyle is key to permanence 19:54 - The importance of measuring progress with tools beyond the scale 20:22 - Integrating blood tests, imaging, and lifestyle logs 20:49 - Systemic approach: nutrition, training, stress, sleep 21:18 - Visceral fat as a reflection of metabolic health 21:46 - Peptides as lifestyle adjuncts, not standalone solutions 22:16 - Why deep visceral fat should be prioritized for health risk reduction 22:46 - Visuals of fat distribution and fat loss versus muscle depletion 23:15 - Peptides' role in health span, not just aesthetics 23:44 - Comparing Tesamorelin with traditional growth hormone therapies 24:12 - Muscle gain limitations and realistic expectations 24:39 - Peptides as tools for fat and metabolic health, not muscle building 25:09 - Broader issues: environment, lifestyle, and societal factors in obesity 25:38 - The importance of healthy habits for lasting results 26:05 - Changing environment to sustain fat loss gains 26:33 - Focus on targeted fat loss and biological change over scale weight 27:01 - Practical advice: measure waist, blood markers, and lifestyle factors 27:31 - Summary: deep visceral fat as a sign of aging; the role of Tesamorelin 27:59 - Trusted peptide suppliers and quality control 28:28 - Final thoughts and encouragement for responsible research and use Resources & Links: Biohacked AF Community & Education Nova Prime Labs (preferred peps) Connect with Kris Gethin: Twitter Instagram Website

Most people think they know what they're eating because they read the label. Grass-fed. Organic. High protein. Product of the USA. Low calorie. Clean ingredients. But that label is the end of the story, not the beginning. The beginning is the soil. The animal. The feed. The farm. The chemicals. The confinement. The way the food was raised, processed, mixed, marketed, and sold before it ever reached your plate. And that's where a lot of people are getting fooled. In this episode of The Kris Gethin Podcast, I sit down with Will Harris, fourth-generation farmer and owner of White Oak Pastures, to break down what most people never see about the food system. We talk about why industrial food became built around cheapness, volume, and taste, why regenerative farming is the opposite of that model, and why knowing your farmer may tell you more than any label ever could. Will Harris is the fourth-generation owner of White Oak Pastures in Bluffton, Georgia. After decades in industrial cattle farming, he rebuilt the farm into a regenerative, multi-species operation focused on soil health, animal welfare, nutrient-dense food, and restoring local food systems. What's Discussed: (03:50) How White Oak Pastures became a fourth-generation family farm. (07:27) Why Will walked away from the industrial farming model he was trained in. (09:22) How regenerative farming changed his soil organic matter from 0.5% to 5.5%. (13:40) Why modern food became built around cheapness, volume, and taste. (19:23) What "Product of the USA" labeling actually meant for years. (23:28) What most people don't know about supermarket ground beef. (44:19) Why real animal welfare includes instinctive behavior, not just food and water. Listen to this episode if you want to understand what's really behind your food, why the source matters, and why the farmer behind the product may be just as important as the label on the package. Find more from Kris Gethin: Website: krisgethin.com/ Instagram: @krisgethin/ YouTube: youtube.com/krisgethin 2 Shred: unmatchedsupps.com/products/2shred Follow Will Harris: Website Link: https://whiteoakpastures.com/ Instagram: https://www.instagram.com/whiteoakpastures/ Thank you to our sponsors: NovaPrime Labs www.novaprimelabs.com Unmatched Supps www.unmatchedsupps.com Biostack Labs www.biostacklabs.com Resources Referenced in This Episode: Red Light Therapy Brand: Red Light Rising Link: redlightrising.co.uk/ Code: GETHIN5 Lumaflex, click here and use Code: KRISGETHIN (10% off) Collagen BPC-157 TB-500 GHK-Cu KPV Cartalax Sigma / Bio Cartilage / Nova Cartilage Vesugen

In this episode, Kris Gethin discusses the science and practical application of peptides like the Wolverine stack, GHKCU, TB 500, and others for tissue repair, skin health, gut integrity, and injury recovery. Whether you're an athlete or interested in longevity, learn how these peptides support regeneration and how to approach their use responsibly. TIMESTAMPS 00:00 - Introduction to peptides and tissue repair strategies 00:27 - Kris on authenticity and setup behind the scenes 0:54 - Overview of the Wolverine stack (BPC 157 + TB 500) 1:24 - Benefits of peptides for skin, ligaments, gut, and recovery 1:51 - Deep dive into the glow stack (GHKCU for skin, hair, tissue) 2:17 - The CLO stack (inflammation and gut health, KPV) 2:47 - Understanding nerve impingement and inflammation support 3:15 - The tissue support pathway and target tissues 4:14 - Effects of training, aging, and lifestyle on tissue repair 5:42 - Why peptide stacks are popular for faster recovery 6:09 - How peptides support weak links in connective tissue 7:04 - BPC 157: mechanisms, benefits, and healing processes 7:32 - Tendon repair, fibroblast activity, and the importance of movement 8:56 - TB 500's systemic role in cell migration and wound healing 13:36 - GHKCU's role in skin, collagen, elastin, and anti-aging 15:02 - Skin health, aging factors, and topical applications 16:00 - Supporting scalp and hair health with peptides and lifestyle 17:25 - The KPV peptide and inflammation control in the CLO stack 19:17 - Using peptides during injury and rehab for real-world results 20:40 - Avoiding reckless peptide use and the importance of supporting factors 21:38 - Combining peptides with diet, amino acids, and sleep for optimal repair 22:35 - The impact of blood sugar control, muscle, and aging 23:34 - The importance of hormonal health and blood work before peptides 24:03 - Sourcing quality peptides: purity, sterility, and brand trust 25:26 - Layers of repair strategy: signals, substrates, load/load management 26:25 - Supporting hair, scalp, and skin with peptides, diet, and diagnostics 27:21 - Gut health and lab testing for comprehensive recovery 28:11 - Disciplinary lifestyle, sleep, nutrition, and environment for best results 29:10 - Kris' resources and community at biohackedaf.com for education and support RESOURCES Nova Prime Labs – High-quality peptides tested for purity and sterility Biohacked AF – Education, courses, community for peptide and biohacking insights CONNECT Kris Gethin: Instagram

In this episode I discuss the science and potential of the peptide epitalon in anti-aging, focusing on its effects on circadian rhythms, telomere length, and cellular health. I emphasize a disciplined, holistic approach to longevity and clarifies the current scientific understanding and limitations. Chapters 00:00 Introduction to Epitalon and Anti-Aging 01:20 Understanding Epitalon's Mechanisms03:41 Telomere Biology and Aging05:54 Oxidative Stress and Anti-Aging 07:48 Practical Applications of Epitalon10:15 Integrating Epitalon into a Longevity Strategy 12:11 MOTC: A Complementary Peptide 14:04 Mapping Anti-Aging Strategies15:59 Conclusion and Final Thoughts Resources My Instagram - https://www.instagram.com/krisgethin/ Epitalon research papers - https://pubmed.ncbi.nlm.nih.gov/12705294/ Telomerase activation studies - https://pubmed.ncbi.nlm.nih.gov/26227894/ Mitochondrial peptides and aging - https://pubmed.ncbi.nlm.nih.gov/31964494/ Preferred Pep Products www.novaprimelabs.com **Join my new platform where I have Peptide courses, article and a community where we talk about all things peptides and longevity: www.biohackedaf.com**