B (5:44)

Thanks. I'm so thrilled to be with you.

A (5:47)

Well, I just wanna start by congratulating you on a fantastic bestselling book, Superagers. I absolutely devoured this and I'm thrilled that you're here because I cannot wait to get into a section of your book about how environmental factors are impacting how we age, our longevity and our health overall. And so I'm thrilled you're here. And what I would love to do is start by having you speak directly to the person who's with us right now and tell them what might change about their life if they take everything that you're about to share with us and teach us today to heart and they put it to use in their life.

B (6:28)

Well, I mean, I think the principal things that we've been known about for years, these lifestyle factors, I call them Lifestyle plus because it's much more than just diet, exercise and sleep. We have to now add in environmental factors we haven't paid nearly enough attention. And the compelling evidence that has come forth on air pollution, microplastics, nanoplastics, and the forever chemicals, these things are having a big impact and we're not doing anything about it.

A (6:59)

For starters, I just want to understand them because I had never heard the word microplastics, for example. I think intellectually or common sense wise, you of course go, oh, well, you know, air pollution of course impacts your health. But some of the statistics that we're going to unpack in your book, in terms of the connection between environmental factors and the diseases that people get and the health challenges that people are facing, it's really scary, Dr. Topol.

B (7:27)

It is scary. And the fact that most people are not aware of the risks and that we're not doing anything about those risks, you know, certain conditions are masked because like a heart attack, we can't really say, oh, it's from this forever chemical, or from the plastics or the air pollution, can't really say because they're so common. It's the number one killer. But when you see the declines in fertility, both among men and women, and you know that these plastics and chemicals are invading the testes and the ovaries and the Reproductive system. Right. When you see young people, as I've seen in their 20s and 30s, developing cancer with no risk, you say, well, wait a minute, these are special groups of people that shouldn't have these things. What is it in our environment that could account for this? And you know, until proven otherwise, these are the things we have to consider are causal.

A (8:23)

I agree with you. You know, as I was reading Superagers, Dr. Topol, and you're going through lifestyle plus factors, it stopped me in my tracks as you started to write about how pollution, how plastics, how the environment that we're living in, how there are household items that are in our homes right now that we use when we cook, that we sit next to at home, that also can impact our health and are playing a role in our longevity. How big of a factor is this?

B (8:55)

If we just talk about the forever chemicals in plastics, they have links to all the adverse health outcomes. Now, for example, we know that more young people are developing cancer than ever before. And it's not just colon cancer, breast cancer, all these types of cancers that were age related. We're seeing people in their 20s now with colon cancer, women in their 30s, young 30s with breast cancer. The question is why? They had no genetic predisposition. We have to think, well, maybe it's related to the chemicals. So some people will say, well, you don't have cause and effect. While others will say, you know what, we got this mechanism of inducing inflammation and being mutagenic that is capable of inducing mutations in our cells which could cause cancer. And we have this new thing we haven't seen before and it just keeps getting worse. It's pretty hard not to connect the two. Right.

A (9:49)

Well, and you write about this like on page 125, you literally say by 2050, if we keep going the way that we are, the number of people dying from cancer is gonna double. Yeah, that your theory that the rise in cancer in young people is due to microplastics and forever chemicals and air pollution and water contamination.

B (10:10)

And add to that ultra processed foods, which also are pro inflammatory and injurious. So just starting, maybe with plastics, Plastic water bottles, plastic bags, plastic everywhere. It's so pervasive. And the problem is we have it in our bodies and it's in our organs. One of the most important studies come out in years about plastics was one from Italy where they looked at people's arteries. These are the arteries in the neck, the carotid arteries, where there's atherosclerosis or cholesterol buildup. And they found that more than half had plastics in their arteries and that those are the people that had over fourfold risk of heart attacks and strokes.

A (10:53)

Wait, so hold on a second. Let me just make sure that the person heard that. So in a recent study, half of people have microplastic buildup in their carotid artery. And of those people that had microplastic buildup, they were four times greater risk for stroke and heart attack.

B (11:11)

That's right. And it was correlated with the fact that if you look at the RAH under the microscope, not only did you see the. The microplastics like polyvinyl chloride, but you saw profound inflammation around the plastic pieces. The other one, of course, was the brain. So this was in people who had died, and they looked at the brain and they found plastics throughout the brain. The spoonful of plastics in the brain.

A (11:33)

Spoonful of plastic in the brain, yeah.

B (11:34)

And wherever there was plastic, guess what? There was local, marked inflammation, just like in the artery wall. So you can't say that this innocuous. Right? This is something that's very troubling and it needs action.

A (11:49)

Well, I just want to try to translate to make sure I'm tracking with you. So the reason why the inflammation is the problem is because if your arteries are inflamed, that means they're going to get blocked, which means they're not going to work.

B (11:59)

Yeah, well, it's not just even the blockage we're talking about. Even in the tissue of the brain outside of the arteries where the plastics can get in, once they get into our tissue, they. They incite a lot of inflammation. This isn't good. Whether it's in the wall of an artery or in the tissue like the brain, they're seen in testes, they're seen in semen, they've been associated with blood clots. They're in women's reproductive system as well. I mean, just as they're pervasive in the air and the water, they are in our bodies, and it's a cumulative exposure.

A (12:34)

I realize this isn't conclusive, but what do you worry about as a scientist in terms of the implications of these environmental factors?

B (12:43)

Well, the two that are especially troubling for our reproductive system, and it's not just for women with fertility, but we're seeing progressively lower sperm counts and sperm function in men. And so we have a big problem with reproductive health. But both forever chemicals which get into the reproductive organs, and also the plastics, nanoplastics, they both can do this. And so that's just One example, people are thinking, oh well, more women are trying to have children at an older age and having infertility. No, it's not just the aging, it's the hit on healthy aging. And so the same thing with men, the more infertile men. And so this reproductive health is just one dimension of the problem. This is likely having an effect on each of the major age related diseases. And the sad part about this is the lobbying against these. So we know there's a big problem, whether it's the air we breathe, the water we drink, our foods and all the others in our personal items and cooking, as you mentioned. Mel, what are we doing about it? Essentially nothing. It's amazing.

A (13:59)

Can you just start by explaining what the heck is a microplastic? Like, I don't even know what this means. And where is it? Is it in the air? Is it in water? Like, is it in the bottles? Like, what is a microplastic, Dr. Toba?

B (14:11)

Yeah, well, you know, it's everywhere. That's the sad part. You can only see them under a microscope. So yeah, it's the plastic bag or the plastic bottle, but it's coming out of these things. And so these microplastics, they are toxins. They are not degradable, biodegradable. So once they come into us, we're stuck with them.

A (14:33)

So for the person who's listening and me, does this mean that there's just particles in the air and the water and in the food and all around us that we are absorbing through our mouth and through our nose and through our skin? That. That's what you mean by microplastics?

B (14:51)

Yeah. So whether we're eating or whether we're breathing or drinking, we're constantly exposed to these. They are in, you know, microscopic minute quantities. But it isn't like they go out. I mean they just, we just are accumulating these into our body.

A (15:07)

What are forever chemicals?

B (15:08)

Yeah, so the, the fancy term for that are perfluorocarbonated alkylating agents. PFAS. PFAS? There's over 10,000 of these chemicals. And the key part is they have a fluoride to carbon, F to C bond and that makes non degradable. So that's why they're here forever. And so they are like plastics. And by the way, some of those chemicals are in the plastics. That's how they're made. They have also pervasive presence. 97% of us have PFAS forever chemicals in our blood, detectable at low levels, some higher than others.

A (15:49)

So where Exactly. Do the forever chemicals come from? Like how are they generated in the air and the water and in plastics?

B (15:56)

Yeah, well, you know, if you really want to get the nitty gritty on that, there's a famous New Yorker article from last year where a 3M employee, Chris Jensen basically was the whistleblower. And the company knew about the injurious effects of these chemicals, but they didn't want to do anything about it. And I mean, it's pretty scary to read this article because it's from the inside and 3M, that's kind of their thing. They just everything is made with forever chemicals, whether it's post its or plastics or, I mean, you name it. We've done nothing to rein this in, which is extraordinary. We know they have a toxic potential and yet just like with the big food industry with Ultra Process and like what we've seen with the plastics industry that rely on them, the companies that rely on these forever chemicals are doing nothing to make a difference. And so we're stuck with these very serious risks with no action.

A (17:07)

What are the top ways that you and I and the person listening are being exposed to microplastics and to the forever chemicals that are impacting our health?

B (17:17)

Well, it is pervasive and like you said, Mel, it's in our air and in our water. But there are certainly things that we could do to lessen the burden. I mean, so for example, wrapping things in plastic is not a good idea.

A (17:31)

I have a feeling that I'm going to Leave this conversation, Dr. Tobel, and throw out everything in my kitchen. Is that what's about to happen?

B (17:36)

Hopefully not. But if you want to be conscious about the burden of plastic intake, which is it's an enormous amount of plastics we're taking in on a daily, yearly basis. Anything we can do to reduce dwell time in plastic, or better yet, not plastic at all, that would be an improvement. In our family, we've made some changes. You know, we're a lot less things that are being wrapped in plastic. The things are sitting in plastic more likely to absorb some of the plastic material. But you know, cooking, you can reduce water bottles. No, not in plastic water bottles. So there's at least something you can do. But it's mainly paying attention to. It's pretty obvious what the plastics are like. For example, when you go to the grocery store, everything's in plastic bags. It's true, it should be cloth. So there's many ways, but it's mainly the attention to what things are being wrapped in or being cooked. In or cooked with make a difference. I mean, for example, we used to have these Teflon coated things like a spatula. Now we have wood. Unfortunately, what we can do on an individual basis is somewhat limited. Right. Because very little has been done to change the environmental burden that all of us face. I mean, we're breathing in these chemicals and nanoplastics. And so it isn't like you can change that very easily. So there's at least something you can do, but it's mainly paying attention.

A (19:06)

Well, one of the things that I think of immediately is that when I go to the grocery store, if I put something in one of those plastic bags in the produce section, I leave it then in my fridge for a week or two before I end up using it and cooking in it. So that's an example of the thing bathing in it. And it's true, when I go to the farmer's market, there's nothing in plastic. People are using paper bags. Or I throw it into my basket and then I store it in the fridge without plastic. And so, you know what would be very interesting is have they ever done a study where like, if I think two people ago, my grandparents, if they were to draw my blood versus Grandma Bippert or Grandma Schneider's blood, I bet that the plastic content in my blood versus theirs must be night and day.

B (19:50)

Oh, no question. Because if you think about the fact that it's in virtually everyone's blood now and it wasn't, you know, 10 years, 20 years ago at detectable, things have changed so much. This has become just an enormous burden to us and we don't do anything about it. So, you know, going back to your point about going to the market in bags, why aren't we using paper rather than plastic? Why isn't that the norm? I mean, we have become so dependent on this. It's just, it's so frustrating to watch this.

A (20:23)

Well, I can also tell how impassioned you are when you start to make the case about infertility rates, rising sperm counts, lowering, the spike in cancers that people are getting diagnosed with when they're young children, middle school, high school, in their 20s, that are not the rates that people were diagnosed just 10, 20 years ago. I can see why, as a researcher, medical doctor, and one of the world's most respected medical researchers, literally in the world, that you're very upset and impassioned about this. This feels like a great moment to hit the pause and hear a word from our sponsors. And I'd also love for you to share this episode with people that you care. This is information that everybody deserves to have and Dr. Toble has so much more to share with you. So don't go anywhere. We'll be waiting for you after a short break. Who's ever cried in a dressing room? Pretty much everybody. Fashion can be overwhelming. This is hot. This is not. That's boring. And that is way too far. We just want great looks with a little edge that meet us where we are. Wrangling kids at the Office Girls night that's evereve their curation of new brands and hand picked trends solves fashion overwhelm and they help you pull it all together. Check out their fall collection called the Art of the Edge and get ready to love your look. Ever stylish, ever you ever Eve shop one of their 110 stores or visit evereve.com I use post it Notes for a lot of reasons. To keep track of deadlines, jot down quick ideas during meetings, leave reminders to feed the dog, call the doctor, or pay the gas bill. But Post it notes aren't just for checklists or reminders. One of my favorite ways to use Post it notes is for encouragement. Tiny notes of love and support for yourself or for the people you care about. Here's one of my favorite tricks. Leave a Post it note on your bathroom mirror. That way, when you walk in half asleep tomorrow morning, you're face to face with a little note from yourself. Crush the day you got this. That little boost matters. Or surprise someone else. Slip one in your kid's lunchbox. Stick one on your partner's steering wheel. Tuck it in a friend's book. Drop one in your neighbor's mailbox. Just a few words on a bright square that says I see you, I believe in you. I'm thinking of you. It's a small gesture, but it sticks with you. Literally. Because encouragement when it's written down becomes real. And Post it makes it ridiculously easy to make someone's day, including your own this back to school season. Share the words that matter most with Post it notes visit postit.com backtoschool did you know that scientific studies show that you make 35,000 decisions a day? But most of those decisions, they don't matter. But let me tell you about a decision that does. Feeling safe in your home. See, when you lock up for the night, you want peace of mind so you can sleep at night. Simplisafe gives you that. Most security systems wait until someone breaks in before they sound the alarm. That's too late. SimpliSafe's new active guard, Outdoor protection stops threats before they happen. AI powered cameras spot suspicious activity. So if someone's lurking, real agents jump in. They speak through the camera. They flip on the spotlights. They can call the police fast. The SimpliSafe system is designed to be proactive, not reactive. Plans start at about a dollar a day, 60 day money back guarantee. Over 4 million people made the decision to trust SimpliSafe. Now it's your turn. Visit SimpliSafe.com Mel to claim 50% off a new system. That's SimpliSafe.com Mel. There's no safe like SimpliSafe. Welcome back. It's your buddy Mel Robbins. And today you and I are learning from one of the most extraordinary and respected medical researchers alive today. His name is Dr. Eric Topol. We have the honor of having him here in our Boston Studios. And Dr. Topol, what if we go through a couple items one by one and have you talk about how they're either the free chemicals in this thing or the plastic in this thing can impact your health and what changes to swap out? Does that sound cool?

B (24:46)

Sure. Sure.

A (24:46)

All right. Cool. I'm going to have one of my. I'm gonn. Our executive producer Tracy, bring over a box of things and you can't see this. If you're listening on YouTube, you can watch this, but I'm gonna narrate this. As Tracy puts a gigantic. And now I'm afraid to have this stuff near me because now I'm like, oh, my God. Dr. Topol just said this is all very dangerous stuff. So let's just start with I've got Tupperware. Tupperware. I'm just got big. You can hear it. These are in my cabinets right now. Talk to me about Tupperware.

B (25:22)

You know, the Tupperware parties you think about, that is like adding the plastic burden that we don't need at all. We should be avoiding plastic containers, which of course are everywhere. If we're going to wait another 10 years before we finally have this cause and effect that's waiting much too long when we can do something now that's beneficial.

A (25:43)

Dr. Topol, I microwave in plastic all the time. Is that okay?

B (25:48)

Hopefully that would be past tense because that is a double whammy. Here you've got not only the microplastics that can get into the food from the plastic container, but now you're heating it up, so you're really promoting it. We know if you heat up plastic, that's the way to get More nanoplastic into whatever you're. You're going to consume. So that you don't want to be using these for microwave plastic.

A (26:14)

Swap out for glass.

B (26:15)

Yes.

A (26:16)

Because if your food is sitting in that, even though it's convenient, it is absorbing more plastic. So the more time something spends in it and if you heat it up, even worse.

B (26:24)

It's a double whammy.

A (26:26)

It's a double whammy because you're releasing more microplastics. All right, I've got hairspray here.

B (26:31)

Yeah. Most of these hairsprays are, you know, chock full of forever chemicals, unfortunately. So if they supply the ingredients and you see any fluorinated stuff in there.

A (26:42)

From alcohol, it's the second thing. Yeah, I can't read half this stuff, but this one has alcohol and then it's like hydrofluorocarbon 152A. There's a methacryolate. A beauty.

B (26:59)

Horrible.

A (27:00)

Really? Why is this horrible?

B (27:01)

Because you're basically spraying forever chemicals on your head. You know, why would you want to do that?

A (27:08)

Okay, that's going down there. I don't want that. I have a scented candle that is. Is so like smelly that I can smell it from here. Bright blue candle. Ocean mist.

B (27:19)

Yeah. It's troubling because it could be emitting forever chemicals. Just the fact that you can smell it without it being lit and the color of it. Right. As well as lack of ingredients. Does it say what's in there?

A (27:33)

Are absolutely no ingredients on this.

B (27:35)

This is troubling. I mean, it's possible that there's no PFAS in it, but my guess is it's got plenty of them.

A (27:43)

How is a scented. See, I love candles.

B (27:45)

I do too.

A (27:46)

But. But how is a scented candle a toxin in the environment?

B (27:51)

Because now you're putting these right into the air you're breathing.

A (27:54)

Okay.

B (27:55)

And so you're basically inhaling these forever chemicals that you don't really want to put into your body.

A (28:02)

Is there a slightly better candle? Like, you see the soy based ones, the can. I don't have any candles that are a color.

B (28:10)

The color might be an indicator that we're getting into artificial stuff.

A (28:13)

Okay.

B (28:14)

But the question is why not put the ingredients, like what you just had for the hairspray, show us what's in it. We deserve that. And if it's got a fluorocarbon in there, we know it's non degradable and it's gonna get in our body and we can't get rid of it.

A (28:30)

All right, let's Talk about deodorant. So this is a deodorant. This one got alcohol and PPG114, beauty, ether, cybo. I don't even know what the hel I see. Paula, is this an indication that this is problematic?

B (28:47)

Well, if it has a fluorocarbon, anything with fluoride and carbon in there or alkylating agents, that's when you get the forever chemical. So that chemical bond is irreversible, non degradable, and just whether you eat something with it or breathe something with it, you're stuck with it forever.

A (29:08)

What about perfume? So I've got perfume here that hydro, like hydro. Okay, I see a lot of methadone, but benzotheminthenol, I can't read this stuff.

B (29:22)

Yeah, that is incriminating again, at least it lists the chemicals. Some of them don't even list their ingredients. Right.

A (29:28)

I don't think mine lists my ingredients.

B (29:29)

But if there's a forever chemical in there, which it sounds like there might, I would try to stay clear of that and stay with ones that, you know, have organic, non chemical stuff in them because you know, then you know, you're perfectly safe.

A (29:45)

You know what's so interesting about this conversation is I'm so psycho about moving my body and getting sleep and eating whole foods, like I call it my grandmother's diet. I just try to eat local. I try to eat whole foods as much as I can. I don't eat out of bags and boxes whenever I can. And so I'm not so about this kind of stuff and I'm just slathering chemicals all over my body and spraying it on me to make it look good. And then drinking out of my plastic bottles and microwaving my whole foods and my plastic containers, it didn't even occur to me.

B (30:19)

This was amazing. When I did the deep dive in researching all the evidence about this, it became much more alarming. I wasn't aware of this either. And there's still some holdouts, there's still some naysayers saying, oh, it isn't as bad as you think. But you know what, when you put these things together, all these so called epidemiologic studies, large cohorts and showing the increase of exposure and how this is so much associated with bad health outcomes and acceleration of our aging process. This isn't good.

A (30:52)

You know, I've seen a lot written recently about also these free chemicals and plastics that are in women's products for menstruation and also baby diapers and can you talk to me A little bit about that. Like what do you looking for? The same thing. And say the chemical again that we're all looking for.

B (31:09)

Well, it's any perfluorocarbon. Unfortunately, there's been a big review of menstrual products and many of them have significant exposure of forever chemicals. And so again, our attention, whether it's the manufacturer or the consumer, is just not there. I mean, if manufacturers really want to be promoting health, they could use different ingredients, different components. Some of them are evidently, but most of them aren't.

A (31:42)

You know, I also have this nonstick techno resistant pan here. It says that it's got titanium in it, it's coated with something. Why are nonstick coated pans a really bad thing to cook with?

B (31:58)

That Teflon or other plastics is getting right into the food. The more you're using it, the more in microscopic quantities. But you're getting into your digestive tract and yeah, it's a problem.

A (32:09)

Well, and plus, I would imagine, Dr. Topol, that as you're cooking something in here and using a plastic cooking utensil and the heat is like heating up the plastic on the pan coating and on the utensil, you're just releasing more microplastic from the utensil and the pan into the food that you're eating.

B (32:30)

Just like the microwave of the Tupperware. Same thing. Heat is just gonna increase the load of the nanoplastics into your body.

A (32:39)

I'm gonna be emptying out a lot of the drawers at home. That's all I can say. What do you think about air filters in the house? I mean, should we all be having one? Is there a certain type of air filter that can help filter the air?

B (32:51)

Well, we do have a problem with bad air, dirty air. And so we saw this of course through Covid. And so had we at our home or our workplace, had better air filtration, we could have reduced the spread of COVID And it's the same with the respiratory viruses, but it also gets us to air pollution. Air pollution. When you get down to the 2.5 particulate matter, the tiny amounts of air pollution, the tiniest.

A (33:21)

What do you mean by that? What do you mean when you get down to the 2.5? I don't know what that means.

B (33:24)

So there's breakdowns of the pollutants in our air. The smaller you go, the more toxic. And again, just like we talked about with the microplastics and the forever chemicals, it's these small 2.5 particulate matter. These are the ones that are throughout our body inducing inflammation. And so anything we can do to have higher quality air, particularly with good filtration. So there are these HEPA filters, but even just exchanging the air, a lot.

A (33:59)

Of people like a fan.

B (34:00)

Yeah, well, fans or you know, normally at a workplace now we have these so called MERV11, MERV13. These are just air filtration systems that are exchanging our air on a frequent basis. The more exchanges, the more filtration, the better quality air. Last year the CDC for the first time said we're going to make a move towards healthy buildings. And that sounded really good. But what's actually being done that involves, you know, much better ventilation and filtration systems and there's little action that's actually been taken.

A (34:33)

So you know, the reality is, as I hear all this, it makes perfect sense. Like I'm not one of those people who's like, well there's not enough evidence to me, if you look at the rise in cancer and the rise of infertility rates and the rise of diseases that people are being diagnosed with at ages in their teens and 20s and 30s that they weren't being diagnosed with 20, 30 years ago, it makes a lot of sense. Like there's no denying to me the connection of all this, but I feel like it feels out of control that oh my God, there's teaspoons of plastic in my body, that it's in my arteries, that it's everywhere around me. The air that we breathe has got God knows what in it. Every product that I'm buying is not labeled. And so I don't know how to look for the free chemical. If you were to say, Dr. Topol, that there are three things that everybody can do and should do that would make the biggest impact in your environmental risks and mitigating against them, what would they be?

B (35:39)

Well, I think firstly it's to acknowledge that these environmental factors are very likely having inducing harm to our body. So, so the first thing is you gotta have awareness of these big three air pollution, the forever chemicals and the microplastics or nanoplastics. So that's step number one. The second one is that we need to what we can at an individual level, family level, reduce the hit. There are many practical things that we can do that we've been reviewing and that at least is doing something active towards trying to reduce the burden. The third thing is we need to start taking on the industry with the help of a government environmental protection that should be a strong factor in all this, that these companies that are the most active in this space that are manufacturing, knowing their products first, not disclosing it it in their, in the labels, secondly, knowing that they're chock full. Like we talked about, the problem that was unveiled with 3M that why aren't they using other components that are not posing risk to our health? Because, you know, when you look at these factors, like for example, now that we know that you can look at all the layers of a person's data and say there's just no reason that person would get pancreatic cancer, there is just no reason at all. But, oh, by the way, they happen to live in a place that's, you know, got very bad air pollution, very significant exposure to these toxic chemicals, plastics, ultra processed foods. Well, what's going on here? So the point is, by diagnosis of exclusion, the fact that we can look at all these other layers of data, say this person presented in their 60s with pancreatic or ovarian cancer, there's just no reason for it. Or lung adenocarcinoma in a very healthy young woman.

A (37:42)

Why?

B (37:43)

Well, all these things we're talking about here, because they induce inflammation, they induce mutations in our cells that could be carcinogenic.

A (37:52)

That's terrifying.

B (37:53)

Yeah, Yeah. I always like to have the hardest evidence to make a conclusion, but this one here has a flashing yellow light, especially when in context of not doing anything about it.

A (38:05)

Well, when you and your work have been cited in 365,000 papers and you've got over 13,000 published papers yourself and you're alarmed, I'm like DEFCON 10 over here thinking, get the plastic out of my house. Dr. Topol, I have so much that I wanna dig into with you, but let's take a quick pause so we can give our sponsors a chance to say a few words. As you're listening to our sponsors, be generous with this. Absolutely everybody that you care about and love deserves this information. And they would love a chance to learn from the extraordinary Dr. Eric Topol. And don't go anywhere because we have more from his new book, Super Agers, when we return. So stay with us. You ever get hot in bed? Whew. The sweaty kicking the sheets off, flipping the pillow over 50 times. Kind of hot. It's ridiculous. And if you've ever woken up drenched in sweat at 3:00am, you know exactly what I'm talking about. Getting good sleep isn't just nice, it's essential. It affects everything. Your focus, your mood, your ability to make it through the day. If your mattress is making you sleep hot, upgrading isn't just smart, it's a power move. That's where Mattress Firm steps in. Mattress Firm sleep experts match you with the right cooling mattress. Like the Tempur Breeze. It's got advanced cooling technology for hot sleepers, plus pressure, relieving support for those annoying aches and pains. And with free and fast delivery right to your door, better sleep starts right away. For the great sleep you deserve, visit Mattress Firm. They make sleep easy whether you're soaking up the last weeks of summer, planning a trip, or just looking for a new challenge before the fall. Rosetta Stone makes learning a language easy. Their method is immersive and intuitive. No boring memorization, no confusing grammar drills. Just quick lessons that fit into your day over coffee, waiting for an appointment even while traveling. And that's exactly how I used it. Before a trip to Greece with my husband, I practiced a little Greek. It was so easy to squeeze it in a few minutes here and there. And it made such a difference. Being able to say simple things like thank you or evaristo connected me instantly with the people I met at restaurants, hotels, even in taxis. That's the power of Rosetta Stone. Quick, effective lessons that turn into real connection wherever summer takes you. Rosetta Stone Learn a language. Make a connection. Don't wait. Unlock your language learning potential now. The Mel Robbins Podcast listeners, that's you can grab Rosetta Stone's lifetime membership for 50% off. That's unlimited access to 25 language courses for life. Visit RosettaStone.com Mel to get started and claim your 50% off today. Don't miss out. Go to RosettaStone.com Mel and start learning today. You know when the team is stretched thin, projects are piling up and everyone's doing three jobs and losing their minds in the process, it's time to hire. And when you need great people fast, there's only one place to go. Indeed. With Indeed's sponsored jobs, your post jumps right to the top of the list for people who are the best match. That means your job gets seen first by the right candidates because you can't afford to waste time. Look, there's no nonsense here. No monthly subscription. No long term contract. You only pay for results. That's why 3.5 million employers around the world trust Indeed. It works. It's fast. When it comes to hiring, Indeed is all you need. There's no need to wait any longer. Speed up your hiring right now with Indeed and listeners of this show will get a $75 sponsored job credit to get your jobs. More visibility@ Indeed.com Melrobbins Just go to Indeed.com Melrobbins right now and support our show by saying you heard about Indeed on this podcast. Indeed.com melrobbins Terms and conditions apply. Hiring Indeed is all you need. Welcome back. It's your friend Mel Robbins. And today you and I have the honor of getting to spend time with and learn from one of the most respected scientists in the world. His name is Dr. Eric Topol and he is here unpacking his evidence based approach to longevity and all of this extraordinary research and his new book, Superagers. So Dr. Topol, what would you say, Dr. Topol, though, to somebody who is listening like somewhere around the world because our audience is global.

B (42:29)

Yes.

A (42:29)

And you know, there is a person that is listening to this who is going to feel so overwhelmed by the chemicals and pollutants that they are surrounded by because of where they live and feel like, well, there's nothing I can do, is there? You know, obviously there's always something you can do. But what is the one thing that you would want this person who's feeling like, well, I live in a polluted area and I, you know, there is no regulation around where chemicals are dumped. What's one thing to really take a look at for yourself?

B (43:05)

Well, the things that we've been discussing, I think, Mel, that at least will reduce that person's burden or their family's burden to some extent and at least that raises awareness so that, you know, everything you're doing now is a bit different. That, you know, when you go to the grocery store or the farmer's market, when you're cooking, you know that you're much more conscious of these potential risks. It isn't like, like you said, defcon. This is not like you're going to die or you're going to wind up in the hospital, but these are this kind of chronic, low level burden things that they're not helping. We know that much.

A (43:45)

Well, it makes you also wonder with the rise of autoimmune disorders and the massive increase in the last 20 years, when you see the rise of infertility rates, as you've suggested, the rise in cancer diagnosis in young people, when you see the rise of autism diagnosis, it does make you wonder how are these environmental factors truly impacting people's genes, people's organs, the way the body metabolizes food and air, the way that the immune system works. And the fact that you're alarmed is very alarming to me.

B (44:21)

Yeah. I think the problem we have is we're In a state of complacency. We've just accepted this. We've accepted this exponential rise of environmental toxins, all of which we've been discussing, induce inflammation in our body, pose a risk of every organ system, as you mentioned, including the immune system, and inflammation. And we're just sitting here in some kind of denialism, as if they're innocuous and they're not.

A (44:49)

You know, you hear people doing cleanses, whether it's going on like a heavy metal cleanse or doing something to reset, you know, their health. Once you have microplastics in your system, can you get them out of your body?

B (45:02)

The problem is the plastics and the forever chemicals are not degradable. So once you. It's a unidirectional thing. You take them in and they're in residence, they establish resonance in our bodies. Who would want that? Who wants these foreign chemicals and materials in our body? Especially when you see them, when you see them in an artery, and then you see surrounding the plastics is this intense inflammation of all these cells that come in that are just. And then you look at the arteries that don't have the plastics in them, and it looks, you know, okay, you say, whoa, I don't want these in my arteries, and I don't want these, you know, in my brain, because they can't be doing anything good there. So that's the problem, is they get throughout our body and they are inducing local inflammation, which is unhealthy. So here on the one hand, we have a lot of good things that we can do to promote healthy aging, but we got this problem that we're basically largely ignoring, and I hope that's going to change.

A (46:07)

Well, one thing that I am getting out of this conversation that I think is really important, number one, is that there are simple changes that I need to make that our family needs to make, now that I'm aware of it, in terms of how we cook the products that. That are certainly in our kitchen, the way that I am heating up food, the containers I drink water in, you know, I grew up in an area where there was a lot of manufacturing and there was not regulations related to the dumping of chemicals in lakes. And there were, when I was growing up, clustering of different types of lymph, nomas and cancers, which of course, all then tracked back to the chemical dumping. And so we know the connection between the environment and people's health, and we know, based on very bad things that have happened, how chemicals impact people's health. And so the fact I agree with you that we're not regulating this or protecting people from it seems profoundly unfair and frankly, stupid.

B (47:12)

Totally stupid.

A (47:13)

I also think if we're already on this hockey stick upswing, what's going to happen in 20 or 30 years? What's going to happen to our kids?

B (47:22)

Well, I really appreciate that point because I mean, the Superagers book is brimming with optimism because we're going to be able to prevent diseases. We have this newfound potential to do that. And we have this problem is the overhang, which is when are we going to get serious about environmental toxins and exposures? They're there, they're increasing. It's undeniable that they're having some, posing some hazard. In order to reap the benefits of this amazing capacity of prevention that we're gonna have, we've gotta pay a lot of attention to this issue.

A (47:59)

Well, I'm glad you brought up optimism because, you know, Super Ager is your best selling book, which is an evidence based approach to longevity and using the science of aging to your benefit so that you age well regardless of whether you're 20 or 30 or 40 or 50 or 60 or 70 or 80. And, and the lifestyle changes that you talk about in the book, whether it's sleep or exercise or eating less processed food or staying socially connected, are the evidence based way to improve your health outcomes. And I'm happy that you also were willing to laser in on a piece of your book that was about the environmental aspect because this is a piece that can feel very overwhelming and a lot of us frankly don't know about it. It. I've prioritized convenience over my actual health and I've prioritized just kind of being laissez faire about it because I didn't understand the deep connection and the actual scary evidence that you've laid out today about how environmental factors are contributing to poor outcomes as you age, regardless of how young or old you are. And so, you know, I am so appreciative, Dr. Topol, that you were willing to make the case and willing to talk to us about some of the simple changes we could make and to get us really revved up about the importance of this as a species, frankly.

B (49:25)

Particularly with children here. They're exposed to lots of plastics and these chemicals and of course it's the duration of exposure throughout a person's lifetime that also plays a role. And I went on a field trip with my 11 year old grandson last Friday, a marine biology field trip. And during that trip the kids all had lunches and it was really interesting that their parents, typically their mothers of course had, many of them had packed things in their lunch, no plastic at all. I said, wow, this is really impressive. So some people are getting the memo, some people are figuring out that there's ways to work around this plastic pervasiveness. And that's reassuring. We all can do better.

A (50:15)

Well, you know, you just mentioned kids and I was just sitting here thinking that if I take all the research that you've laid out and I think about my own life, 56 years old, and you talk about the rise of this in the last couple decades, I probably for the first 20, 25 years of my life was not exposed to microplastics. It's only been in the last couple decades that I have been. But when I think about my kids who are now 26 and 24 and 20, they've been exposed to this for their entire life. And you know, we love to point the fingers at social media, which certainly has its upside and massive downsides, especially in the development of young brains. But it makes you wonder, is the rise in adhd, especially the early diagnosis and other neuro divergent issues also partially because of these environmental toxins? And again, don't know. But when you really look at the research and the evidence, it's hard to deny that it's gotta be a contributing factor.

B (51:19)

That's the way I see it, Mel, because there's no way these things are good for us. And when you see the rising incidence of these things, there is no other explanation. It's hard to point away from this as a root cause. These things can't be good for us. And let's assume that they're bad for us and do something about it.

A (51:38)

Dr. Chopal, if the person listening does just one thing when they're done listening to all this that you've shared with us today, what would the one thing be?

B (51:49)

Well, I still want to leave a person with a very optimistic outlook that we have a capacity to prevent diseases that's more powerful than ever before in medical history. But we have to pay attention to the problem that is happening at the same time, which is steadily worsening, which is that we have these unwanted foreign toxins in our environment, in the things that are being manufactured, we're taking them in on a daily basis and that has to get, get on track. We just can't keep going on and expect to reap only the benefits without the concurrent risks that exist today. So I do hope that while we are in prevent mode, we pay More attention to this other issue, which is that we have a few layers of environmental exposures, each of which we can do something better with them to reduce them. But it's also going to take a collective of population wide attention to really make a difference.

A (53:00)

What are your parting words, Dr. Topol?

B (53:02)

Well, I couldn't be more excited about the ability to prevent the age related diseases, the ability for us to take a huge dent out of cancer, out of Alzheimer's and Parkinson's, along with cardiovascular disease, that being the number one killer throughout the world. There's never been better prospects for that and we have many ways we're going to achieve that. But let's not forget that alongside has been a creeping up of our environmental factors that are getting in the way. So let's make sure that we pay attention to that and take it seriously from here on in.

A (53:44)

Well, what I really appreciate about you is that. But underlying that message is the environmental factors aren't your fault, but now that you see them, you can do something to protect yourself against them. And now that you understand the bigger picture and how this is accelerating, you can be part of a solution that helps resolve these environmental factors for future generations. Dr. Toble, thank you, thank you, thank you for writing such a remarkable book, Superagers. Thank you for hopping on a plane and thank you for making this extremely compelling and alarming case and empowering us to make simple changes to protect ourselves.

B (54:20)

Thank you.

A (54:21)

And thank you. Thank you for taking the time to listen to something that could absolutely change your life. And there's no doubt in my mind that Dr. Topol's research and his new book, Superagers, has all the information and the simple changes that you can be making in your life, in the life of the people that you care about that will add years to your life. And I really hope you take everything that you learned today heart. And in case no one else tells you, I wanted to be sure to tell you that I love you and I believe in you and I believe in your ability to create a better life. Thank you for listening to something and for wanting to learn from somebody as smart and as researched and as respected as Dr. Eric Topol. Thank you for sharing this and I'll see you in a few days. I'll be waiting to welcome you in to the very next episode the moment you hit play. I'll see you there. Okay, you ready? Okay, great. Oh, I love that. Wow. So good. Well, thank you. See what happens. Okay. Okay, great. Okay. All right. That was so good. My God. Get it away from me.

B (55:33)

Well, you don't want to interrupt this couple.

A (55:36)

Oh, we will. I mean, she can fly in for production. I live in Southern Vermont.

B (55:40)

Oh, yeah. Oh, good, good. But what if she's on the other side of the country?

A (55:43)

She'll fly over just like you did. She'll be here for five days, right?

B (55:47)

That's great. I love it.

A (55:49)

Dr. Topol. I microwave in plastic all the time. Is that okay?

B (55:54)

I wouldn't advise it. Hopefully that would be past tense.

A (56:03)

Oh, and one more thing. And no, this is not a blooper. This is the legal language. You know what the lawyers write and what I need to read to you. This podcast is presented solely for educational and entertainment purposes. I'm just your friend. I am not a licensed therapist, and this podcast is not intended as a substitute for the advice of a physician, professional coach, psychotherapist, or other qualified professional. Got it? Good. I'll see you in the next episode. SiriusXM Podcasts.

B (56:47)

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A (57:16)

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