Transcript
A (0:00)
I'm Louise Nicola, and this is the Neuro Experience. I found a study showing that women with gum disease take, on average, two months longer to conceive. But it gets worse. The bacteria P. Gingivalis has been found in placental tissue of women who miscarried. I mean, I'm talking bacteria in the gums of these women. I have received DMs from women who have spent years trying to conceive. And their reproductive endocrinologists are running every single test except for checking their oral microbiome or the oral health. So I need you to tell me right now, what's the link here?
B (0:38)
We are working on changing this. Like, imagine if fertility clinics were oral microbiome testing and asking couples about their oral health. That's really what we need to move toward. So the studies that you're referring to is from the University of Western Australia. And it looked at. It was a cohort study, and it looked at 3,800 women, and it did find, on average, it took about two extra months to conceive when women had active periodontal disease.
A (1:06)
So cohort is where they track them over time, correct?
B (1:09)
Yes. And so why is that? So periodontal disease is a chronic state of gum disease. And so that involves certain pathogens, P. Gingivalis being one of them. And there's something called leaky gums. We've all heard of leaky gut and intestinal permeability. But now I want everyone to think of leaky gums. So do your gums bleed when you brush and floss? That's a sign of inflammation. That's also now a way, a vector for this bacteria to get into the circulatory system, where they release exotoxins and have cytokine release, and they cause inflammation, they can cause DNA fragmentation, and it can impact our fertility, endocrine disruption. And this includes not just with women, but men also, it can impact sperm mobility, sperm motility, sperm count. And so imagine if we started looking and testing patients, oral microbiomes to see do they have these pathogens. And you wouldn't know necessarily until you test. And just like we're getting into gut mapping, I really would like us to move toward oral microbiome testing, too, because we know there's so much connection between the state of our mouth and the state of our other systems.
A (2:24)
A few years ago, I came across a study linking pingivalis periodontal disease to Alzheimer's. And we saw that it went from the gum through the vagus nerve and then into the brain, the vagus nerve is the tenth cranial nerve. And that's the idea that I know. But how are we seeing that pathogen go from the gum all the way down to the placenta or the ovaries and causing these issues?
B (2:48)
