Podcast: Plain English with Derek Thompson (LS 62 · TOP 0.1% what is this?)
Episode: The Pill That Works Even When You Know It's Fake
Pub date: 2026-03-13

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Why do placebo effects work, even when patients know that they're taking a sugar pill? How do "nocebo" effects work, and why do some people hold onto beliefs that they suspect might bring them pain and suffering? What do the major world religions have to teach secular athletes and workers about the power of belief, and what does the psychological research tell us about the benefits of prayer, even for those who don't believe in God? Nir Eyal, bestselling author of the new book Beyond Belief, joins the show to talk about the research behind how our beliefs shape our lives.

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Host: Derek Thompson

Guest: Nir Eyal

Producer: Devon Baroldi

Today’s open is adapted from Derek’s Substack essay “If Placebos Work So Well, Why Not Prescribe Sugar Pills For Everything?”

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