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I've benefited from that, it has broken the previous automatic response pattern that was not serving me well. Yeah. What's interesting about that predisposition to problem solve, like, I would imagine your inner monologue is like, this is a positive quality. Like, when I see a problem, I solve it right away. But if you're curious about why that is, perhaps you may find a deep discomfort with uncertainty. You know, it's like, what's driving behavior. Right. And that uncertainty is so uncomfortable that it has to be eradicated. And the best way to eradicate it is to just solve the problem. Right. Well, as opposed to what does it feel like to sit in that uncertainty instead? Or you could sit in the uncertainty. That's one thing you can do. You can also productively distract from the uncertainty and let time temper the emotional response linked with whatever is driving the uncertainty and see what that does for you. Or you can talk to someone else. You got to be careful who you talk to to help you reframe the uncertainty. Or you can lean on your culture for support, and if you believe in a higher power or are spiritual, activate some of those resources. There are lots of things you can do to deal with that experience. And one of those things, or two or three, may be far more productive than the default, which is to just try to kind of hammer it away with the worries. We continue with longevity scientist Valter Longo. What's interesting about your work is that, and maybe what's somewhat unusual about you as somebody who is a research scientist, is that you are thinking about how you balance your discoveries around efficaciousness with sustainability and adherence in the general population. It's one thing to look under a microscope, have a discovery, and extrapolate from that into some sort of principle, but how can that be translated into something that the average person can take and use, sustain, that will benefit them over time? Yes. And I think that we want to take it all the way to disease cures, not just treatment cures. Right. So now, for example, with diabetes, we now have three or four trials, all of them showing a 50 to 70% regression of the disease. And then on the FMD. On the FMD, just once a month without changing their diet. And that's a very important thing. Right. So we don't change our diet, we don't change our lifestyle. And we're saying, so, you know, for thousands of years people have been talking about food as medicine, Right. But then really never happened. Right. So that's what we're trying to do. Say, can we standardize this vegan based medicine and then use it to in some cases even cure diseases? And so diabetes, I think is definitely one of the ones where we were very confident. And so University of Leiden or the University of Heidelberg did the first trial a couple years ago. It showed impressive, impressive effects on A1C, but also on reduction of drug use. And then Laden repeated and got the same results. And so I think, yes, this is feasible ways to bring people back to a functional state, from a disease state to a functional state. And I think that a lot of that has to do with molecular mechanisms that are much more sophisticated than people may imagine. So for example, we just published in collaboration with Laura Perrin at Children's Hospital, we published on the use of the FMD in rats with kidney damage and then in people with kidney disease. Right. But in people, of course, we don't get to see what happens, but in rats we get to see what happens. And it's really remarkable. So we damaged the kidney and you see a complete disruption of the gene expression. So our genes are turned on and off in the different cells of the kidney. And then we start the fasting, mimicking diet. And you see that. So there is a very precise architecture, let's say, right, three dimensional, and that is completely destroyed by this toxin that we give the rats. Right? Then we start the fasting, mimicking diet cycles. And you see everything going back to where it was, almost like a magic intervention. So it's not really the fasting mimicking diet that is doing anything, right? It is the rat that always. And people are the same, that always had programs that are able to be triggered by fasting to turn on regenerative and developmental like programs. So the same genes that are used when the kidneys are first generated in a baby, like pluripotent stem cell generation, Is that what you're talking about? Yes, yes. So the cells are being reprogrammed into some of these reprogramming factors, Yamanaka factors, also known as Yamanaka factors, are turned on and you see that every organ is turning on different ones. Right. So in some cases you see October four being turned on. In some cases you see myc. So different organs use different ones, but they all have the same thing in common. They turn on these many genes that are involved in cellular, in organ generation. And then that's how they can go from this very disrupted state back to the previous healthy states. So they know exactly what to turn on to fix the problem. So then that's the power of these fasting, migraine diets, so turning on the ability of the body to fix itself. And so now, you know, diabetes, we're seeing it, we're seeing now with kidney disease, we are now seeing it with, I mean, at least this is in humans and animals, but for some other like gut, we are clearly seeing it in animal studies. And now there are many a number of trials that will test it in clinical trials Here. We've got a lot more to come, but first, a quick break. Today's episode is brought to you by Roka. You know, it's funny, we don't often think of eyewear as performance gear until it starts to get in the way. And if you're like me, somebody who has contended with eyesight impairment my entire life, it's a very real thing. Without a real solution for athletes, I cannot tell you how many times I've been mid run. Constantly shoving my glasses back up my nose, tripping on roots and rocks because I couldn't see them or my glasses had fogged up. Or what about out on the bike where the treachery is obviously far more intense. Well, this is why Roka has been a godsend for me. Approaching prescription eyewear from a performance perspective first. But not at the cost of fashion. 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Everything you want out of a vehicle, of course, but also because of their ethos, which is making the world a better place, providing what you need to make the most of life's adventures and using technology to do it so you're prepared for whatever comes next and have everything you need for every adventure you can imagine. Okay, let's get back to the show with a clip from personal development expert and best selling author Mark Manson. We're in like this guru sphere, right? Particularly in the self help world where there are outsized personalities out there who are commandeering like very large audiences and a significant mind share amongst a vast population of people who are probably genuinely looking for good advice and guidance at some period in their life in which they need it. But back to kind of what YouTube and the Internet rewards it rewards hot takes, contrarianism, heterodox thinking, certainty, conviction, charisma, all of these things. None of which necessarily are related to truth, veracity and good advice. So you, as somebody who I know, thinks about how do I provide good advice and do it with integrity? You're out there not competing, but you're, you're in a world in which those other people are out there for better or worse, who are motivated not by values necessarily, but more and more by metrics like growth. And with growth that means platforming people who might be not the best people to platform under the rubric of just asking questions and all of that kind of thing. Let me tell you what they don't want you to know and, and everything you've ever been told is a lie. And this is what works, right? I don't know if it's a willful blindness or a lack of self awareness or maybe just I don't give a fuck, it doesn't matter as long as I'm growing and more and more people are paying attention to me. Yeah, I have mixed feelings about this because I think it's good for the world. Actually. Let me start with a caveat and then I'll go into my mixed feelings. So the caveat of all of this is I want to say that as this is simultaneously happening, the guru sphere, as you put it, I really like that word is exploding. Right. Self help is bigger than it's ever been. It's become mainstream, essentially. There is an unprecedented wealth of genuinely good mental health and physical health information that's become available in the last 10, 15 years that was never available in all of human history. There's probably been more good advice shared on the Internet in the past 15 years than the rest of human history combined. So that's mixed in with all this stuff. And it's often very, very frustrating as a consumer to parse the good from the bad. Even people who by and large have ridiculous positions and beliefs about most things will occasionally share a really good piece of information. So it's like there's a mental struggle of sifting through all the information out there. So I want to put that on the table first. And then that relates to my mixed feelings in the following way, which is, ultimately, I feel like it's a good thing to let two opposing narratives into the public sphere and let them kind of combat each other, because a lot of times the conventional narrative does end up being full. I mean, how much nutritional information over the past 20 years that was conventional turned up to be absolutely terrible and horrible for people a decade later? Right. So it's like the conventional wisdom does get overturned frequently. And so you do want it to be free and available for people to attack and combat and offer alternative theories and. Yeah. Even if occasionally they're harebrained. Sure, whatever. That I think is fine. And I do think it does cause a lot of stress and strife among the population and among consumers. It makes our lives a little bit more complicated as it puts more responsibility on us to figure out what we're consuming and whether it's good or not. What I do worry about is, to your point, the over indexing of Crazy Town, let's call it. I've kind of come to, just as somebody who's observed online media my entire adult life and tried to really kind of track it and understand why certain audiences behave certain ways, I've kind of come to the conclusion that perhaps the most chronically online population in the world are the Crazy Town conspiracy theory people. They're more engaged, they're more vocal. If they like you, they'll watch everything, they'll like everything, they'll comment on everything. And so I think as creators, I think there are a lot of people in our industry who they'll dip their toe in that pool in the crazy town pool. And they'll get that flood of engagement. And that feels good. It's like, especially, I mean, when you've been, say, grinding through 20 episodes and you're at this plateau and like nothing's really popping off or performing well and you're like, man, what am I? What are we doing wrong? Like, what could I be doing better? And all of a sudden one just like shoots off like a rocket and like, man, I should do more of that. Next up is the iconic Maria Shriver.