The 5-Step System That Will Reset Your Body & Help You Live Longer

Fri Aug 15 2025

Dr. William Li reveals groundbreaking discoveries about the four specific gut bacteria found in people who live beyond 100 years, and how you can cultivate them starting today. This conversation completely reframes our understanding of longevity, showing how your gut health might be the missing link to preventing dementia, healing your body, and adding quality years to your life.

Transcript

Lewis Howes (0:00)

There is one main thing that is blocking you from reaching your full potential. And it's all because you're trying to do everything alone. And that's a big problem because real growth happens when you build a community, when you're in a room full of people who want to see you thrive, who support you becoming your best self. And if that's something you're looking for, then make sure to join me at the summit of greatness live at the iconic Dolby Theatre in in Los Angeles down in Hollywood, September 12th and 13th. Because this year is a powerful lineup of incredible speakers and performers like gabby Bernstein, like Dr. Tara Swart, like Brenda Bouchard, Amy Purdy, and so many more inspiring surprise guests. You'll experience a couple days of transformation and inspiration and deep connection with a community that actually gets you and wants to see you thrive. Tickets are selling fast, so go to lewishouse.com tickets right now to get your seats. Bring your friends and family, and I can't wait to see you there at the summit of greatness very soon. Welcome back, my friend, to the school of Greatness. It is a beautiful day. It's a blessed day and I'm grateful for another opportunity to live on purpose. I hope you're doing well today. I've gotten so many messages lately from so many of you who have just been so grateful for the content we've been providing for the interviews for the guests. And it means a lot to me every time I get a message from someone on social media or when someone comes up to me on the street and just says hello. And their biggest takeaway from the show, it really means a lot to me. We have got a big one. His name is Dr. William Lee. He's a physician, a scientist and a researcher. And we had him on the show before it got millions of views over on YouTube and the audio. But he is back and Dr. Lee reveals how our gut bacteria communicate with our brain, our immune system and overall health in ways that we are just beginning to understand. He's going to share some simple changes to our diet and lifestyle that you haven't heard before on any other show on how it can nurture beneficial gut bacteria and potentially adding healthy years to our lives. We all want to live longer and we all want to live healthier with the current days and years that we have. His a practical approach proves that optimizing your longevity isn't about expensive biohacking but about working with your body's natural healing systems. And he's going to share the four specific gut bacteria that stand out in people who live beyond 100 years and which foods help them flourish. This is going to be so powerful. Please share this with one friend and really send this out to a friend that you think could improve the quality of their health. Or maybe their mind's been a little bit foggy or they've been feeling stressed or anxious. There is so much that's connected to the gut, what we eat eat in our our mood and our brain health and our brain function. So it's not always about losing weight or something like that, but it's about optimizing the way our brain and our immune system work in tandem. And that's what this is about. So share this with one friend. If you're enjoying this, please leave a review over on Apple Podcast or on Spotify. Make sure you're following us on those platforms as well so you can stay up to date on all the biggest guests that we have coming out every single week. And also make sure to get a copy of Make Money Easy, the new book, which is about creating financial freedom and living a richer life. Without further ado, let's dive into this episode with Dr. William Lee did you.

Summary

Podcast Summary: "The 5-Step System That Will Reset Your Body & Help You Live Longer"

Podcast Information:

Title: The School of Greatness
Host/Author: Lewis Howes
Episode: The 5-Step System That Will Reset Your Body & Help You Live Longer
Release Date: August 15, 2025
Description: Lewis Howes hosts inspiring interviews with some of the most successful people across various fields to help listeners unlock their inner greatness and live their best lives.

Introduction

In this episode of The School of Greatness, host Lewis Howes welcomes Dr. William Lee, a renowned physician, scientist, and researcher specializing in cancer and longevity. Dr. Lee delves into the intricate connections between gut health, brain function, and overall longevity, presenting groundbreaking insights into how simple dietary and lifestyle changes can significantly enhance one's lifespan and quality of life.

Understanding the Gut-Brain Axis and Longevity

Dr. William Lee emphasizes the profound impact of gut bacteria on overall health, noting, "Our gut bacteria communicate with our brain, our immune system, and overall health in ways that we are just beginning to understand" (04:56). This gut-brain axis plays a crucial role in neurodegenerative diseases like Alzheimer's and Parkinson's, suggesting that optimizing gut health can contribute to both mental clarity and increased lifespan.

Key Insights:

The gut microbiome consists of approximately 39 trillion bacteria that influence various aspects of health.
Destabilization of gut bacteria can lead to increased inflammation, compromised immunity, and cognitive decline.
Recent discoveries reveal that the brain itself has a microbiome, with about 20% of its bacteria shared with the gut, underscoring the deep connection between gut health and brain function.

Four Essential Gut Bacteria for Longevity

Dr. Lee identifies four key bacteria prevalent in individuals who live beyond 100 years:

Odoribacter
Oscillobacter
Cristinellaella
Akkermansia

He states, "These bacteria improve your metabolism, lower inflammation, help your immunity, lower your cholesterol, and support brain health" (26:05). Akkermansia, in particular, is highlighted for its role in enhancing immune response and potentially reversing cancer through immunotherapy support.

Dietary Recommendations to Cultivate Beneficial Gut Bacteria

Dr. Lee provides practical dietary advice to nurture these beneficial bacteria:

1. Incorporate Polyphenol-Rich Foods:

Pomegranate: Contains Ellagitannins that support Akkermansia growth.
Chili Peppers and Black Raspberries: Promote the flourishing of essential gut bacteria.

"A medium-sized pear has 5 to 6 grams of dietary fiber, which can decrease mortality by 30%" (53:40).

2. Utilize Resistant Starches:

Refrigerated Cooked Potatoes: Transform starches into resistant forms that feed healthy bacteria.
Green Bananas and Plantains: Naturally high in resistant starches.

3. Reduce Ultra-Processed Foods:

Dr. Lee explains, "Ultra-processed foods with artificial preservatives and colorings can kill your gut bacteria, disrupting the symphony of your microbiome" (56:35).

4. Adopt a Plant-Based Whole Foods Diet:

Emphasizes eating minimally processed, whole, and fresh foods to flood the body with beneficial polyphenols and dietary fibers.
Encourages cooking at home to avoid the harmful effects of factory-processed foods.

Lifestyle Changes for Optimal Gut Health and Longevity

Dr. William Lee outlines a straightforward five-step system to reset the body and promote longevity:

Eat More Plant-Based Whole Foods:
- Focus on fresh, unprocessed ingredients to nourish beneficial gut bacteria.
Don’t Overeat:
- Practice mindful eating by serving smaller portions and stopping when satisfied, not necessarily full.
"Stop before you're full. You're satisfied before you're full" (62:13).
Skip Meals Occasionally:
- Implement intermittent fasting by skipping breakfast a few times a week to extend the body's fasting period and promote metabolic health.
Engage in Physical Activity:
- Incorporate brisk walks after dinner to aid digestion and support immune function.
Prioritize Quality Sleep:
- Ensure deep REM sleep to enable the glymphatic system to cleanse the brain of toxins, enhancing cognitive function.
"When we get good sleep, the glymphatic system opens up and drains the toxins from your brain" (67:26).

Impact of Negative Factors on Gut Health

Dr. Lee discusses various factors that can harm the gut microbiome and impede longevity:

Alcohol and Smoking:
- Both introduce toxins that negatively affect gut bacteria and overall health.
Vaping and Environmental Toxins:
- Chemicals from vaping and even exposure to cooking fumes for restaurant workers can disrupt gut bacteria balance.
Lack of Exercise and Poor Sleep:
- Both contribute to an unhealthy gut microbiome and weaken immune responses.

Supplementation for Gut Health

While emphasizing whole foods, Dr. Lee acknowledges that certain supplements can support gut health:

Vitamin D and Omega-3 Fatty Acids:
- Essential for brain health, immune function, and reducing inflammation.
Probiotics:
- Specifically Lactobacillus reuteri, which supports immune health, lowers inflammation, and promotes the release of oxytocin, the "social hormone."
"Lactobacillus reuteri makes your brain release oxytocin, enhancing social bonding and happiness" (31:19).

Mindset and Gut Health

Dr. Lee underscores the bi-directional relationship between mental health and gut health:

Stress, Anxiety, and Depression:
- Negative mental states can adversely affect the gut microbiome, leading to a vicious cycle of poor health.
Positive Thinking:
- Enhancing mental wellness can bolster gut health, contributing to overall longevity.
"We often disconnect mental wellness with physical wellness, but there's profound interconnectivity" (77:24).

Conclusion and Key Takeaways

Dr. William Lee provides a holistic approach to enhancing longevity through gut health, emphasizing that small, manageable changes can lead to significant health improvements. By prioritizing whole, plant-based foods, mindful eating, regular physical activity, adequate sleep, and strategic supplementation, individuals can nurture their gut microbiome, support their immune and brain functions, and ultimately live longer, healthier lives.

Notable Quotes:

"Real growth happens when you build a community, when you're in a room full of people who want to see you thrive" (00:00).
"Longevity is not about setting a number; it's about enjoying the journey and maintaining health along the way" (40:17).
"We're all hardwired to actually heal. We can get back to that healing" (40:49).

Additional Resources:

Books by Dr. William Lee:
- Eat to Beat Disease
- Eat to Beat Aging
YouTube Channel:
- DrWilliamLee – Regular updates and in-depth research discussions.

Join the Conversation: For those inspired by this episode, consider implementing Dr. Lee's five-step system and explore more of his research through his books and YouTube channel. Embrace these scientifically-backed strategies to reset your body, enhance your gut health, and pave the way for a longer, more vibrant life.