Physicists at the LHC reported a four-sigma anomaly in B meson decay - a 1-in-16,000 deviation from Standard Model predictions - while Google committed $40 billion to Anthropic, Isomorphic Labs confirmed AI-designed drugs are heading to human clinical trials, and 75% of Google’s new code is now machine-generated.

https://sharedsapience.com/the-century-report-april-25-2026/

The LHCb experiment measured both angular distributions and decay rates in an electroweak penguin process, and both diverge from what the Standard Model predicts. A separate detector, CMS, published independent results last year pointing in the same direction. The LHCb team has already collected three times more data than the analyzed dataset, with upgrades planned that will multiply statistical power by fifteen. If the deviation holds through five-sigma confirmation, it would represent the first evidence of physics beyond the Standard Model in decades - and the analytical intelligence brought to bear on that confirmation will be categorically different from anything available even two years ago.

Google’s $40 billion Anthropic investment - $10 billion committed immediately at a $350 billion valuation - arrives days after Amazon’s $5 billion pledge. Anthropic’s two largest investors are now also its two sole infrastructure suppliers and its two direct competitors. Google provides TPU chips, Amazon provides Trainium chips, and both compete with Anthropic through their own model families. The entanglement deepens a pattern with no precedent in prior technology eras: capital flows in, compute capacity flows back, and the organizational boundaries between rival, investor, and supplier dissolve.

Isomorphic Labs confirmed it will begin human clinical trials of AI-designed molecules in oncology and immunology, with president Max Jaderberg claiming computational protein understanding produces drugs that are “very, very potent” at lower doses with fewer side effects. The FDA approved Regeneron’s Otarmeni gene therapy for hearing loss - with the company offering treatment free to all eligible U.S. patients - and issued priority vouchers to three psychedelic therapy companies studying psilocybin and methylone for depression and PTSD. Google disclosed that 75% of its new code is now AI-generated and reviewed by human engineers, up from 25% in October 2024. Time framed “too dangerous to release” as an emerging industry norm, with Mythos, GPT-5.4-Cyber, and GPT-Rosalind all restricted from general public access.

Additional Reading:

* Yahoo News/Phys.org - LHC Penguin Decay Anomaly: https://www.yahoo.com/news/articles/evidence-starting-mount-physicists-large-203000107.html

* TechCrunch - Google to Invest Up to $40B in Anthropic: https://techcrunch.com/2026/04/24/google-to-invest-up-to-40b-in-anthropic-in-cash-and-compute/

* Wired - Isomorphic Labs AI-Designed Drugs Headed to Human Trials: https://www.wired.com/story/wired-health-2026-how-ai-is-powering-drug-discovery-max-jaderberg/

* Time - ‘Too Dangerous to Release’ Is Becoming AI’s New Normal: https://time.com/article/2026/04/24/claude-mythos-chatgpt-rosalind-release-dangerous/

* Shared Sapience - The Century Report April 24, 2026 (DeepSeek V4 and GPT-5.5): https://sharedsapience.com/the-century-report-april-24-2026/

* Shared Sapience - The Century Report April 18, 2026 (GPT-Rosalind and Scientific Acceleration): https://sharedsapience.com/the-century-report-april-18-2026/

Want to track and verify all the “everything is changing” claims I’m making? I just launched a public Progress & Claims Tracker that logs breakthroughs, slowdowns, and outright contradictions, so my own theses can be challenged by the evidence in real time. Check it out. And hey, why not subscribe while you’re there?https://sharedsapience.com/progress-and-claims-tracker/

The Century Report is a facts-rooted, and therefore relentlessly optimistic, daily briefing on AI, science, energy, and the systems reshaping civilization — grounded by rigorous evidence from the stories of exponential progress happening every single day. Completely free. New release daily. Archives can be found at the link below. Subscribe to get TCR delivered daily directly to your inbox.

https://sharedsapience.com/century-report/

The Shared Sapience Substack:

Want to get started with learning about or working with AI?

I’ve helped hundreds of clients with their own journeys into this brave new world, and I can help you too. If you’re interested in personalized guidance, consulting, or workshops, reach out to me at ben@sharedsapience.com

FOLLOW SHARED SAPIENCE ON SOCIAL:

Bluesky: https://bsky.app/profile/sharedsapience.substack.com

Facebook: https://www.facebook.com/sharedsapience

Instagram: https://www.instagram.com/sharedsapience/

LinkedIn: https://www.linkedin.com/company/shared-sapience/

Threads: https://www.threads.com/@sharedsapience

TikTok: https://www.tiktok.com/@sharedsapience

X (Twitter): https://x.com/SharedSapience

SUBSCRIBE TO THE PODCAST:

YouTube: https://www.youtube.com/@SharedSapience/podcasts

RSS: https://podcast.sharedsapience.com/podcast/rss.xml

Spotify:

Apple:

Get full access to Shared Sapience at sharedsapience.substack.com/subscribe

The Standard Model Cracks - TCR 04/25/26