The Spiritual Hustler Podcast

Host: Jessica Zweig
Episode: Unlocking Microdosing: Rewire Your Brain, Shift Your Subconscious, and Regulate Your Nervous System
Date: November 20, 2025

Episode Overview

This episode of The Spiritual Hustler dives into the practice of microdosing—specifically psilocybin mushrooms—as a tool for personal growth, manifestation, and nervous system regulation. Host Jessica Zweig shares her own multi-year journey with microdosing, breaking down the science, the spiritual implications, and the direct impact on women’s lives and businesses. She emphasizes reverence, intention, and the unique adaptation of microdosing for the female body. This solo Unlocking Series segment is rich with personal insights, actionable advice, and a clear invitation to rethink the intersection of entrepreneurship, spirituality, and wellness.

Key Discussion Points & Insights

1. Reframing Hustle: The Feminine Approach

• Jessica reminds listeners that her show is about “redefining the word ‘hustle’” and reclaiming work from a place of love, meaning, and wholeness—not lack or survival. She positions spiritual practices, like microdosing, as tools for this new paradigm.
  • Quote:

    "We don't hustle for money. We hustle for meaning... We hustle toward healing the ancestral programming of fear and step into a new understanding of safety in the body." (01:34)

2. Why Microdosing?

• Microdosing is presented as more than a trend—it’s “an ancient remembrance that humanity is waking up to” (07:25).
• Not about getting high, but about subtle, embodied transformation: “It becomes a frequency tool... a gentle amplifier of who you really are.”
• Jessica notes she has been practicing for nearly three years and fields frequent questions from her female community.

3. Science of Microdosing Psilocybin

• How it works:
  • Psilocybin at sub-perceptual doses (tiny amounts) activates serotonin receptors, specifically 5HT2A, and increases brain-derived neurotrophic factor (BDNF), described as “miracle grow for the brain.”
  • Helps break rigid thought loops, supports neuroplasticity, and decreases activation of the default mode network (DMN)—linked with stress, anxiety, and negative self-talk.
• Quote:

  “BDNF is like--think of it like miracle grow for the brain. It creates new neural pathways; it breaks rigid thought loops.” (09:19)

• Effect: Interrupts “past-based thinking and limiting identity loops,” promotes presence, and helps “your brain have literal room to choose new thoughts which equal new actions which equal new emotions.” (11:01)

4. Microdosing for Manifestation: Rewiring the Subconscious

• True manifestation is not magic, but the “repetition of thoughts and emotions and actions that match what you desire.”
• Most limiting beliefs are deeply rooted in the subconscious, frequently formed before age seven.
• Microdosing creates brain plasticity and softens “subconscious gates,” letting new empowering beliefs integrate faster.
• Quote:

  “Microdosing helps loosen the grip of old ‘I’m not enough’ identity so you can dissolve the programming, so that you literally shift your frequency.” (13:50)

• Increased emotional tolerance is noted as a key benefit: “Most women aren’t actually afraid of failure. They’re afraid of success and what that success is going to require of them.” (15:30)
• Maintains sustained alignment for intentional manifestation, allowing for expanded capacity and congruence.

5. Regulating the Nervous System

• Manifestation thrives when not in survival mode; regulation of the nervous system is crucial.
• Microdosing supports this balance by optimizing serotonin pathways, lowering physiological stress, and creating a “sense of safety and openness” in the body.
• Quote:

  “If your nervous system is dysregulated, your body cannot hold, literally cannot physically hold, the frequency of abundance, expansion and desire that you are calling in.” (17:58)

• Benefits include deeper meditation, more manageable emotional experiences, and a foundation of safety—enabling mind and intuition to flourish.
• Jessica underscores that “when the body feels safe, the mind can expand. And when the mind expands, your field becomes magnetic.” (18:41)

6. Microdosing for Women: Personal Experience with Microflow

• Jessica partners with and endorses Microflow, a product formulated specifically for women’s hormonal cycles.
• Microflow’s two blends: Exude (used during the follicular/ovulation phase) and Surrender (used during the luteal/menstrual phase), matching the 28-30 day cycle. For those who do not bleed, syncing with the moon is advised.
• She credits microdosing for clarity, deeper embodiment, congruence, intuition, bravery, and especially for softening her personal block around receiving: “Manifestation becomes a bigger byproduct when you have this coherency in your own inner system of receptivity.” (21:10)
• Quote:

  “I became braver. I became more intuitive. I became more aligned in every single aspect of my life.” (19:40)

7. Intention & Reverence: It’s Not a Hack

• Jessica warns against treating microdosing as a casual supplement; instead, approach with reverence and intention.
• Recommendations for ritual:
  • Hold the dose, tune in to gratitude, clarify your intention and ask for support—“Give the mushroom an assignment. It has an intelligence.” (22:29)
• Quote:

  “This is not a hack... This is a relationship. It is a sacred relationship with the mushroom.” (22:03)

8. Manifestation and Synchronicities

• With coherent action and consciousness, “manifestation becomes totally inevitable. Sycnchronicities explode, clarity deepens, and your business will respond—because now you’re manifesting from coherence, not fear.” (24:41)
• Jessica’s experience: transformed her life, her husband’s life, and those of friends and community members.
• Quote:

  “I really believe that it is returning from the earth to help all of humanity heal.” (25:44)

Notable Quotes & Memorable Moments

• “We don't hustle for money. We hustle for meaning... We hustle toward healing the ancestral programming of fear and step into a new understanding of safety in the body.” (01:34)
• “Microdosing… is an ancient remembrance that humanity is waking up to.” (07:25)
• “It’s not about getting high. It’s micro, somatically intelligent, sub-perceptual... it is a gentle amplifier of who you already are.” (08:04)
• “BDNF is like miracle grow for the brain.” (09:19)
• “We don’t manifest by putting shit on a mood board or affirmations or communing with the moon… Manifestation requires you ultimately to become the woman who already has the thing and to move like her.” (13:11)
• “If your nervous system is dysregulated, your body cannot hold, literally cannot physically hold, the frequency of abundance...” (17:58)
• “I became braver. I became more intuitive. I became more aligned in every single aspect of my life.” (19:40)
• “This is not a hack... This is a relationship. It is a sacred relationship with the mushroom.” (22:03)
• “Manifestation becomes totally inevitable. Synchronicities will start to explode everywhere you look.” (24:41)
• “I really believe that [psilocybin] is returning from the earth to help all of humanity heal.” (25:44)

Timestamps for Key Segments

• 00:52 — Show Theme & Mission Statement
• 06:15 — Microdosing: Ancient Practice & Current Popularity
• 08:04 — What Microdosing Is (and Isn’t)
• 09:19 — The Science: Serotonin, BDNF, & Brain Rewiring
• 11:01 — Microdosing and the Default Mode Network
• 12:22 — Subconscious Impact & Childhood Conditioning
• 15:30 — Emotional Tolerance and Fear of Success
• 17:58 — Nervous System Regulation Explained
• 19:40 — Jessica’s Personal Experience with Microflow
• 21:10 — Receiving and Inner Coherence
• 22:03 — Intention, Reverence, and Ritual
• 24:41 — Manifestation, Synchronicities & Closing Thoughts

Conclusion

Jessica Zweig’s episode on microdosing is both deeply personal and educational, blending neuroscience, spiritual practice, and practical application for modern women entrepreneurs. Listeners are invited to consider microdosing not as a shortcut or commercial hack, but as a sacred and intentional tool for transforming one’s consciousness, receptivity, and manifestation capacity—a process that ripples outward into all aspects of life and leadership. The emphasis is on feminine alignment, ritual, and honoring plant intelligence, positioning microdosing as a bridge between science and ancient wisdom for today’s businesswomen.