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Your body makes T2. And research shows that T2 can mimic T3 activity inside metabolic tissues without raising blood T3. So without needing to take more T3, T2 can actually mimic that same activity. Isn't that exciting? Welcome to the new and completely reimagined Thyroid Fixer podcast, a podcast that refuses to sound like every other health show out there. We're here to disrupt this entire space, and now you are part of that disruption. If you're listening right now, it's because something inside you finally said, I'm done being ignored. And I'm here to tell you. Good. Because this is where everything changes for you. This is where you say, no more. No more being dismissed by your doctor. No more being told your labs are normal. No more recycled medical advice. No more recycled biohacking advice. No more being told you accept what you know is isn't right here. You'll get truth. You'll get clarity. You'll get information you can actually use, tools, strategy, and guidance you can apply right now to take back your energy, your hormones, your metabolism, and your life. Every episode will give you something real, something that moves you forward, something that reminds you that you were never the problem, the system was. This is the Thyroid Fixer podcast. This is your turning point. This is where you rise. Get ready. We're about to disrupt everything you thought you knew about thyroid and hormone health. Let's go. I need to talk to every woman who's been told your labs are normal while your body is screaming at you and rebelling against you. Fatigue, brain fog, the weight that will not come off, mood swings, hair loss, feeling dismissed, frustrated and confused. I get it. And that is exactly why I wrote my new book, the Thyroid Fix. The no nonsense Guide to Fix fatigue, fogginess, and fat that won't budge. That just says it all. And it is now available for pre sale. So I need your help to spread the message. I am giving you an ask as my listener and a promise at the same time. If you pre order the thyroid fix, my promise to you is to continue delivering all kinds of free advice, information, content, education, empowerment, because that's what I love to do. Whether it's here in the just fix your thyroid Facebook group or I'm on live, I will give you everything I possibly can if you do me one favor, which will be a favor for yourself as well. And pre order the thyroid fix. Now, this book is not another list of supplements, vague advice. It's not a diet plan. It's not filled with recipes. It is a clear, honest Guide it is the Thyroid Bible. It is the last thyroid book that you will ever need because it teaches you how to read your own labs. No other book has done that. It teaches you what medication and dose you need. No other book has ever done that. It will help you to understand why you are being misdiagnosed, why you're being under treated and why you can't talk about hormones, weight loss or menopause without talking about the thyroid. I called the Thyroid Bible because like I said, this is going to be the thyroid book of the next few decades. When you pre order, you're not just supporting me, you're telling the publisher. This message matters and it needs to get out to the world and it needs to get into the hands of women who have been ignored for far too long. So will you go to thyroid fixbook.com and pre order a copy of yours today? It'll be shipped to you on May 12th and you will get free entry to our all day live event where I will be there answering your questions live, teaching live and bringing in amazing guests for you to also connect with and ask your questions too. So thyroidfixbook.com pre order yours today. Today we are talking about something we actually have not discussed yet on the Thyroid Fixer PODC past. But I decided to go a little bit deeper into the science so that you can really understand thyroid signaling at the tissue level, how T2 can act like T3 in your system. So if you can't get a hold of T3, your doctor says no, you don't need it, or uses fear mongering to scare you away from taking it. This episode is for you because the bottom line is without some type of action at your tissue level, at the cell level of active thyroid hormones, whether that's T2 or T3, without that action, you will remain sick. You will continue gaining weight, you won't be able to lose weight, you will remain exhausted, your hair will keep falling out, your joints will still hurt, your brain will still be foggy, you'll still have low mood, you'll struggle with anxiety and depression. You, you'll get band aid medications for it. Your cholesterol will be high, your blood sugar will be off, your stress response will be low and you won't poop every day like you should. And then that ties into detox. And then of course you'll be cold all the time, your heart rate will be slow, your brain function will be slow. You will be set up for advanced diseases of aging over time because you're not Addressing your low and slow thyroid function. It's time to so wake up. This is going to be the episode that you need to listen to to better understand thyroid hormones actions at the cell level are diodase enzymes a little more advanced. I know we haven't talked about that yet. As well as T2 and T3's action as the active thyroid hormone. So let's get into this. First of all, thyroid hormones, it's important to know this, that when we test your blood, of course we are testing for the thyroid hormones that are in your bloodstream, but they don't work in your blood. They work in your cells. They work at the cell level. So just like we say, every single cell in your body has a little receptor site on it, like a lock and key mechanism for T3, not for T4, not for T1, the inactive thyroid hormone, but for T3 specifically. Now you're sitting there wondering, well, wait, what about T2? But you said we were going to talk about that. Well, T2 can, as we've said in previous episodes, grab onto an iodine molecule and it can become T3. But T2 has an action in and of itself, an independent action on the receptor site. So we're going to talk about that. So first of all, knowing that these thyroid hormones work inside the cell, we have to go inside the cell. We have to go to the powerhouse of the cell, which is your mitochondria. Remember, all the way back, let's rewind, maybe seventh and eighth grade science class. This is when we learned about the cell and the cell's action. So the mitochondria is the little metabolic engine house, the little powerhouse inside of your cell. And that mitochondria works on so many levels in your body. Number one, producing ATP, adeno triphosphate, that's going to give you energy, and that has a whole other working action in your body that we're not going to get into in this show. But it's important to note, even just from an energy standpoint, especially if you're dealing with hypothyroidism, that, yeah, we want to produce ATP at the cell level. So when we look at your lab values, those are the numbers in your blood. They tell us what is circulating, what actually be picked up by the cell. But they're not telling us what our tissues are actually receiving. And we have to remember that the real thyroid power happens at that cell level, at the mitochondrial level. So that really is why two people with the same labs can feel completely different. And this is also why I say the four most important words that any practitioner should be asking you that you're working with is, how do you feel? Because you have to layer how you feel. You have to layer that on top of the labs. And then we can say, okay, Sally, look over here. Your reverse T3 is through the roof. Your free T3 is in the basement. That is why you have fatigue and weight gain and hair loss and XYZ at the same time. Believe me, I've looked at many a lab. Thousands, thousands of labs. I can tell you that an elevator reverse T3, that really doesn't lie. Usually when a person has an Elevator reverse T3, we're not going to hear from them something like, I feel great. I have no symptoms at all. No, they're going to have symptoms. However, a free T3. So let's just say this individual has a reverse T3 less than 12. Awesome. And then we move over to their free T3, and it's a 2.7. And then we say, Ms. Sally, how do you feel? I feel great. Like, I really have no symptoms. I feel the best I have in my life. Okay. Then there's the same lab result in two separate people, and they feel completely different. This is why thyroid optimization is nuanced. You have to layer how you feel over your labs and look at it from that lens. So, but to understand why T2 is so interesting, we have to understand how T3 works inside of the body. So let's do that, and then we'll layer in T2 hormone receptors. Thyroid hormone receptors. We're getting a little bit geeky now, so put on your science hat. So, first of all, T3 doesn't just, like, float around your system randomly. It has to bind to thyroid hormone receptors inside the cell. So there are two main receptors. There's TR Alpha. This is the metabolic accelerator. So TR Alpha lives heavily in your heart, your skeletal muscle, your brain, your bone, and your GI tract. And this receptor controls your heart rate. This is why you might have a very low and slow resting heart rate. Your heat production, whether or not you are burning fat, thermogenesis, burning of stored body fat, and even your temperature regulation. This is why you feel cold when everyone else is totally comfortable. Muscle activity. So even the contraction and action of your muscles, neurological function, your brain function, your memory, your cognition, your focus, your motivation, your concentration, your mood, and then gut motility, whether or not you poop every day. So this is exactly why low thyroid function equals slow heart rate, fatigue, constipation, cold, brain fog, all the things and if you happen to have high thyroid function, as in Graves disease or hyperthyroidism, which we don't see as often, but this totally explains if the TR Alpha receptor is over activated, you're getting the heart palpitations, you're getting anxiety, you might get a tremor in your hands. So TR Alpha is actually your survival accelerator. Now TR beta is your metabolic regulator, not the accelerator. This is the regulator. Then Snoop Dogg have a song or I think in Dr. Dre, I'm going way back to my hip hop 90 days regulator. Okay, so TR beta is concentrated in your liver. So think detoxification. This is why I always say these people with detox protocols that just claim these wild claims like all you have to do is detox and you'll be fine. Yeah, no. The liver performs over 500 metabolic processes. One little cayenne pepper detox is not going to help your liver become healthy and do all that it needs to do in a day. So TR Beta, thyroid receptor beta concentrating the liver. We got the fat tissue pituitary in your brain. So remember the HPT axis, hypothalamus, pituitary, thyroid access pituitary signals and releases TSH or thyroid stimulating hormone. So the pituitary is responsible for that and then different parts of the brain. So this particular TR beta receptor controls your cholesterol metabolism. This is why you might have an elevated lipid panel. If you are hypothyroid, it controls your fat oxidation, the burning of stored body fat, your triglyceride handling. So whether or not, again, when we're looking at that lipid panel, are your triglycerides elevated? And you're like, wait, what's happening here? Fatty liver disease is huge with hypothyroidism, non alcoholic fatty liver disease. And then of course, as we mentioned, that TSH feedback to the pituitary, if TR beta is not working properly, we're going to get some rocky feedback to the pituitary where TSH might be falsely elevated high or falsely suppressed low. This is where T2 becomes fascinating because T2 appears to favor the TR beta dominant metabolic tissues like the liver and the muscle. Even when your blood level of T3 or free T3 doesn't rise, T2 can actually be acting on the metabolic regulator, the TR beta receptors. It can actually be working on those. And this is where we see an improvement in fatty liver disease. Multiple studies showing an improvement in fatty liver. With the use of T2, we see an increase in your baseline metabolic rate, your basal metabolic rate, the amount of fat that you burn at rest. We are seeing an increase in that with the use of T2, even without T3. Now, you can have normal T3 on the lab. You can have low activity inside your cells. You can also have pretty much optimal, because, you know, I hate using the term normal. But you can have optimal blood T3 or free T3 levels on your lab test and very strong signaling inside the tissues. So this is again where it comes back to the question of how do you feel? Because I'm going to say it over and over again. Thyroid optimization is a nuanced art. Unless you are working with someone or a group, like at the Advanced Thyroid Hormone Clinic. I'm just saying, that's what I built. No one on my team works for me unless they know the thyroid inside and out like I do. And my team has been with me for years. So unless you are working with someone that knows what in the hell they are doing with the thyroid, you're just not going to get better. You're just not. I just as a side note, like a little side tangent here, there are many practitioners who are claiming to be able to treat your thyroid. There are influencers that are now all of a sudden popping into the thyroid space, which cracks me up, especially when guys come in, because as we know, this is a woman's disease. Yeah, okay, a couple of you dudes out there do have hypothyroidism. But whenever I see a man, an influencer man in the functional space, right. He might even have a doctor in front of his name, get up and start posting or start talking about the thyroid and how you don't need that thyroid hormone. All you need to do is XYZ to fix your thyroid and get well. And it's usually just some hocus pocus. I also, I'm pretty sure I'm going to be copied very soon here by a gentleman influencer in the health space talking about thyroid. I just laugh because I'm like, you know, if a man who has never had a thyroid problem or has never been through perimenopause and menopause wants to talk to me about how I don't need bioidentical hormone replacement or I don't really need thyroid hormone. I just need to take his product or do his protocol. My response is, can we cut off your testicles and then withhold testosterone from you? And will you be singing the same song that you don't need hormones? Are you. Are you really. Are you going to be on your hands and knees begging, begging for your testosterone Replacement therapy. Because now you know what we feel like when our hormones crash. And even if we're just talking about thyroid, they don't know. They want to understand, and they want to use it as a promotional tool. But unless you have walked in these shoes, I know what it's like. That's why I'm here. That's why I'm telling you this information. That's why we have 610 different podcasts. That's why I have a free Facebook group. That's why I go on every single week, giving you my time to answer your questions for free. Because I have been there in your shoes. I have gained the weight, I have lost the hair, I've battled the fatigue. And this is only my 20s, when I was supposed to be living life and feeling great. So unless a practitioner has what they claim that they specialize in, you close your eyes, you cover your ears, and you walk away. I told you this was a little side tangent. Now we'll get back to the episode. Okay, so again, we can have two people with lab results that this one. Oh, my gosh, free T3.2.7, but she feels phenomenal over here. This one, wow. Free T3 of a 3.5, and she feels like garbage. So you have to ask that person, how do you feel? And you have to look at it through these trained, nuanced glasses, or else you're not going to catch it, or else you're going to tell that woman with a 3.7. Free T3. Oh, you're fine. Your. Your labs are optimal. You're good. Well, no, obviously there's something going on at the cell level that even though it looks pretty on paper, she is still struggling. And symptoms tell us everything. Because if you still have symptoms now, sometimes with the back off and go, okay, these symptoms could be tied to hormones, they could be tied to low ferritin, they could. Could be tied to other things. But in general, when we look at it, hey, you know, if it walks like a duck and sounds like a duck, quacks like a duck, that kind of thing must be a duck. So, same thing when we're looking at a woman who has a host of thyroid symptoms. We can move over here and go, ah, yeah. Okay, well, we have to look at your thyroid labs through the lens of those symptoms that you're dealing with and not just check the box and call you good. Because thyroid action at the cell level actually depends on receptor availability. And unfortunately, I know your question. Is there a way to test it? No, there's Not. This is where the nuance art comes in. And listening to you, cellular conversion. We can see that in reverse T3. We'll talk about that more today. Enzyme regulation, the diodase enzymes that we're going to break down today, you're going to learn about those and whether or not the hormones are actually being delivered. So let's move on to the diodase enzymes. These are the gatekeepers. Right? So thyroid hormones are the messengers. Diodase decides whether the message gets delivered or not. So there are three of them. Dio1, this is your converter. Dio1, the converter lives in your liver, your kidney, and the thyroid gland. Its job is to convert T4 to T3. And this is why I say if you have had a total thyroidectomy and you are given T4 only, it is medical malpractice because you just remove the gland that produced the active thyroid hormone, T3. You also removed the main conversion gland. Yes, DIO1 still does live in liver and kidney, but it lives in the thyroid gland. You moved one out of three conversion forces conversion sites. DIO1's job is to convert T4 to T3. That's its job. Now, it does help to support your serum, your blood T3 levels. It helps support cholesterol metabolism and liver metabolic output. Now, T2 has been shown to increase DIO1 activity in liver. This is why T2 helps with conversion. If you are on T4 only, God forbid, but maybe you are. Maybe you're stuck on it. If you are on natural desiccated thyroid medication, which is 80% T4, you need help converting. Short of you being on T3 only. If you're on T3 only, continue listening, because I think it's important to get educated. But if you're on any amount of T4 whatsoever, you need to add in T2 to increase that DIO1 activity in your liver to help with conversion, because this is going to equal stronger local thyroid signaling. So we're going to get a louder signal to your cell that is starving for active thyroid hormone without forcing blood T3 higher. So we can amplify the message at your cell level without pushing up T3. If you are exhausted, gaining weight, you have brain fog, you just feel off, and you're tired of doctor hopping and wasting money. Listen closely. So many women bounce from provider to provider, trying supplements, protocols, and then functional approaches that never truly address the thyroid. Months turn into years and you're still stuck, feeling like garbage, wasting your precious life. So this is why we offer a Thyroid and hormone solution call. It's not a lab review. It's not treatment. It's clarity and strategy to determine whether you're a good fit. Fit for working with our clinic. We specialize in thyroid optimization and hormone optimization together. Because they go hand in hand. You can't do one without the other. You have to do them both. We prescribe in all 50 states, and if you become a patient, we take care of you from start to finish. Testing, treatment, optimization, and ongoing support. You don't have months or years to waste feeling this way. And you shouldn't have to keep throwing money at people who don't truly understand the thyroid and hormones. So if you're ready for real help, go to drami.com that's D R A M I E dot com and click book a call in the top right corner to schedule your thyroid and hormone solution call and just let us help you get your life back and be that badass human that you are meant to to be. That you deserve to be. Now, why is this also important for many, many individuals? Because there's many of you out there who cannot tolerate increasing your T3. You either get anxious, jittery, you start just losing your mind. I get it. I totally get it. Now, if you go Back to episode 602, this is where we talk about what to do if you can't tolerate what or you can't increase your T3. But this is going to be one of the key factors in getting you better and getting your life back is if we can increase conversion of T4 to T3. And this can be the conversion of your own thyroid gland too. So let's say you still have your thyroid gland. You're producing T4, you're producing a little bit of T3, but that T4 is just struggling to convert over to T3. Now, this is how our body was made. It was made to convert, but let's face it, doesn't always do so. So we are working to convert T4 to T3. We need to give our body help with that. This is where T2 comes in. Because you're going to amplify the message at the cell level. Hey, give me a metabolism. Hey, let me poop every day. Hey, cell, let's grow some hair and stop losing it. Right? So we need that stronger local thyroid signaling now. Dio 2, this is the protector. Dio 2, the protector lives in your brain pituitary. Also in your brain, lives in your skeletal muscle brown fat placenta. Its job is to make sure critical tissues always have enough T3. It's protecting. It's protecting brain function. It's protecting your mood, it's protecting cognition, is protecting your pituitary signaling. And this is why lab numbers don't always match symptoms, because we don't know. We can't measure necessarily what D1O2 is doing, because it's in parts of the body that we can't, like, biopsy to get some DIO2. We can't do that, but we know it's important. Now, DIO3 is the break, and this is that connection to reverse T3. So DIO3 shuts down, down thyroid signaling so you can see DIO1. Oh, my gosh. So vital. It's converting. It's converting. It's acting in so many different ways, is so vital. DIO2 is protecting us. Now DIO3 is kind of just screwing us over and putting the brakes on. So this DIO3 is what takes T4 and converts it to what we don't want. Reverse T3, it takes T3 and converts it to inactive metabolites that we can't even use. And Dio3 really amps up and starts appearing, because we're calling it the metabolic brake pedal. It starts appearing in stressed tissue or injured tissue, inflammation. We see it in fetal development. We see it in illness. If reverse T3 is elevated during conception, it can unfortunately end in a miscarriage or just affect fertility in general. Fetal development is where we see the baby's brain not develop increased risk or increased rates of developmental delays and autism. I often talk about my stepson. I truly, truly, truly believe there's hypothyroidism there in the mom. And that wasn't tested, that wasn't treated. This is why I urge women everywhere to just take your time getting pregnant. Make sure that your thyroid is optimized prior to getting pregnant, because if you do have issues with conversion, if that DiO3 enzyme is amped up, then you can affect your baby's brain development 100%. So we know reverse T3 is our survival mechanism, and it's built into our body for a reason. Because it's your body basically saying, like, slow down, conserve energy. Just sit there, survive. If you're lying in the ICU or the ER and you're fighting for your life, it's going to shut down your weight loss effort. You don't need to burn fat while you're lying there trying to survive. You don't need to have sex. You don't need to make major decisions so that it we know is is built into us for a reason and we know that it rises during stress. Chronic dieting, inflammation, illness, trauma, starbation, ICU states. I mean, listen, this is intelligent biology right here. But in modern life, when stress becomes chronic, inflammation becomes chronic, dieting becomes chronic, then your metabolism is going to stay stuck in survival mode. So we need reverse T3, but we don't want it while we're trying to walk around living life. So what drives Dio3 and reverse T3? So chronic cortisol stress. Chronic cortisol suppresses activation enzymes and increases dio3. So stress. Think about being stressed. Think just picture that DIO3 increasing, which is going to push up your reverse T3 and push your body into a hibernation survival mechanism mode. Inflammation kicks up cyto kindes which signal energy conversion again. Hey, body, conserve that fat. Conserve that energy. You don't need to burn fat right now. It's good if you're starving or extreme dieting, the body thinks that famine is happening. We talked about this in the 1990s, the whole, what was it, starvation phenomenon to where, okay, if you don't eat enough calories, your body is going to hold on to fat, not burn it, no matter what you do, because your body thinks you're starving. That is a real thing and that is actually tied to the DIO3 and reverse T3 mechanism. Illness, trauma, metabolism is going to shut down to preserve survival. Some genetics come into play here because some people do convert better than others. But lifestyle still has a stronger influence on the enzyme balance over genetics. It really does. So this is where T2 fits in. So T2 is a naturally occurring thyroid metabolite. It's an exogenous thyroid metabolite. But your body already makes it. It's not synthetic, it's not foreign. Your body makes T2. And research shows that T2 can mimic T3 activity inside metabolic tissues without raising blood T3. So without needing to take more T3, T2 can actually mimic that same activity. Isn't that exciting? So even if we can't get our hands on T3, if our doctor has a cap on it, if our doctor says no, if you're living in a different country where it's absolutely impossible, like Canada, hello. And the UK and Australia, because I've had patients from there and man, is it frustrating getting your hands on T3. You can use T2. T2 can mimic T3 activity inside tissues without raising blood. T3. I'm going to say it again. T2 can mimic T3 Activity in your body at the cell level, at the tissue level, without actually needing more T3. Wow. Just let that sink in for a moment because this is an answer that we have been looking for, I've been looking for, even for my listeners, for my followers, for you, for you to have as an alternative. And, you know, I actually go back, oh, 20 years now. 20 years. I've been studying T2. And I remember when I was not virtual, I was just brick and mortar seeing patients in person. I had in my desk drawer this product, and it was a bro science product, and it meaning it had an angry name with a gorilla with claw marks on the front of it. And I would pull out this bottle and I'd hand it to my patient who was stuck on T4, only that we could not convince her doctor. And this is long before we could Prescribe in all 50 states, the whole deal. You know, I would have patients come in to see me from a different state, come to the office, and there was nothing we could do with their thyroid medication. We could do all the other things to improve conversion, to look for the root cause, to lower inflammation, all the things. But unless their doctor was on board with changing their thyroid medication, we were stuck. So I would hand her this bottle and say, trust me, I know it looks crazy. I know there's a gorilla with claw marks on the bottle. Just trust me on this one. And she would take it and it would work. And we would see, even without adding in T3, we would see this thyroid hormone actually work in her body to transform and change it. Amazing. So T2 activates T3. Like gene programs. T2 will activate many of the same genes that T3 does. So T2 is mimicking. It's acting like T3, especially in liver, in skeletal muscle, in metabolic tissues. Now the liver behaves like it's receiving a stronger thyroid signal when we add in T2. So this is going to lead to increased fat burning because we have to burn fat in the liver. We have to detoxify and burn fat. It's going to lead to improved mitochondrial output. Remember the powerhouse of the cell, ATP? It's going to lead to better lipid metabolism, a better cholesterol panel, reduced fatty liver and stronger metabolic activity. Stronger metabolism. A stronger metabolism equals fat burning. Period. End of story. A stronger metabolism equals fat burning. These are all the classic T3 effects. Even when the labs don't change, T2 is mimicking T3 at the cellular genetic level, at the liver level, at the metabolism level. Everything that T3 does. T2 can do as well without actually changing T3 in your blood. So basically, T3 writes the blueprint. T2 comes in and activates it turns the engine on. T2 directly stimulates mitochondrial respiration. What does this mean? If T2 is working really fast at the mitochondrial level, what is this mitochondrial respiration happening? This is more oxygen consumption, more ATP production, higher cellular energy output, which equals rapid metabolism activation. So this is going to increase your energy, increase your fat burning. That's layman's way of saying, better energy, better fat burning. Now, T2 helps to bypass these conversion bottlenecks. So we already said, when stress or inflammation pushes the body toward that DIO3 dominant pathway, then T2 is going to come in and bypass that traffic jam. So it's not going to force your blood levels of T3 up much. Now, there can always be some activation of an iodine molecule coming, attaching to T2, thus turning into T3 and raising it in the blood. So you might see a free T3 level go from a 2.5 to a 2.7 or 2.8, something like that. Very small bump in the actual blood marker of free T3. However, stronger activation at the cell level when it comes to how do you feel and your symptoms, as well as of course, your cholesterol panel, your lipid panel, your liver enzymes, all of that, because it's not forcing blood T3 up, it's working at the cell level. So it's going to enhance that metabolic signaling directly improve mitochondrial function. T2 is actually going to increase the DIO1 activity in the liver and support tissue responsiveness. Now, remember DIO1. This is your converter. So when we can activate more of the D101 in the liver, we're going to see an improved conversion of T4 to T3 and less conversion of T4 to reverse T3. We don't want the reverse T3. So it's bypassing those bottlenecks, it's improving conversion, it's supporting tissue responsiveness. T2 is actually tissue selective. It appears to be more biased toward metabolic tissues than heart stimulation. So we know that when we take T3 and maybe you're one of them. And this is going Back to episode 602. What if you can't tolerate or increase your T3? If you're like, ah, my heart, it's beating, it's fast, it's rapid, I got palpitations, the whole deal. T3 is not going to stimulate your heart. So those of you who cannot tolerate T3, you can take T2 because T2 is going to be more biased toward increasing your metabolism and not providing a stimulant effect. It has stronger liver and muscle effects. It protects your muscle. T3 will burn muscle and fat. T2 only burns fat less nervous system over stimulation. So you're not getting that anxious, jittery, amped up feeling like you can get with T3. Now the big question is, T2 is strong as T3. So now T2 is not identical to T3. It binds to receptors differently. But in certain tissues, it can produce T3 like metabolic effects. And where it is stronger, where T2 is stronger than T3 is in the fat burning department. Because T2 has a very, very strong impact on your thermogenic effect on your baseline metabolism, the amount of fat that you're burning at rest, and your body's ability to burn stored body fat as fuel, I. E. Thermogenesis, it is a much more powerful action on your metabolism and on your mitochondrial function and ATP production than does T3. So T3 is kind of acting on the whole body, right? T3 is acting on all the different mechanisms, all the different cells, whereas T2 is coming in and saying, let me help you convert that T4 to T3. Let me bump up your metabolism, let me give you more energy. And yeah, oh, by the way, I'll work on some of these other systems of the body too, to help you poop a little bit better, to improve your mood, improve your brain, brain function. But really, what I really like to do as my powerful T2 molecule, what I really like to do is actually act at the metabolism level, at the cellular level, because I want to give you better fat burning and better energy. That is what T2 is basically saying to us. So why does this matter? It shifts the conversation from lab numbers to what is going on at the cell level. Thyroid health is receptor signaling. It's enzyme balance, it's mitochondrial power, and it's how your tissues are responding. So T2 sits right at that intersection. Right at that intersection. So when you are told that your labs are normal, but you still feel exhausted, you feel inflamed, you feel stuck, you feel dismissed. We have to look deeper. We got to go beyond TSH. You know that we have to go beyond T4. We have to go beyond the normal range and look at the cellular thyroid action, your enzyme balance, your tissue metabolism. This is where the T2 conversation becomes so vital, because thyroid physiology is not just. Not just circulating hormones, it's cell signaling. And when we support that level, then metabolism can change. T2 very important in my opinion for everybody to be taking. I mean, this is really a no duh supplement right here. I truly believe that everyone should be on T2 for improvement across the board. From cholesterol to fatty liver to metabolism to brain function. Across the board. But especially if you are on T4 only. Especially if you have weight to lose. Especially if you have low energy, if you're on NDT medication, if your practitioner will not give you T3, if you can't tolerate T3, you can't increase your T3. Everybody listening to the sound of my voice should be on T2. Because even if you haven't been diagnosed with a thyroid problem, if you are carrying around excess weight, we know this increases all cause mortality. Every single chance you have a dying excess weight is so inflammatory that it increases your risk of all cause mortality. So get that weight off to be healthy. No, this isn't a beauty competition. Get the weight off to be healthy. Carrying around excess fat isn't healthy. I don't care if you're in a body shape, movement or whatever, carrying around excess weight is not healthy. Get the weight off. Use T2 to support your entire system. My God. Especially if you're on T4 only. And this will improve longevity. Longevity is such a buzzword these days. This will improve your longevity as well as your aesthetics and your quality of life. So once again, Thyroid Fixer and metabolism fixer in my line has C2 if you're wondering where you can get it. I've been studying this for 20 years now and yes, of course I put it into my supplements. That was the first thing out. That was, that was, that was the launch. The launch of Fixer Formulas was launched with T2 because I've been studying it for so long. So I hope this episode educates you and geeks you out a little bit because I know it does me. So until next time, thank you so much for listening. The information shared on the Thyroid Fixer Podcast is intended solely for informational and educational purposes. It is not a substitute for professional medical advice, diagnosis or treatment. 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