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Nutrition is the foundation for everything that we do. If food isn't right, nothing else can be right. So we have to get the foundation first, and then it's building on that foundation with the systems that we're talking about.
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Welcome to the new and completely reimagined Thyroid Fixer podcast, a podcast that refuses to sound like every other health show out there. We're here to disrupt this entire space, and now you are part of that disruption. If you're listening right now, it's because something inside you finally said, I'm done being ignored. And I'm here to tell you good, because this is where everything changes for you. This is where you say, no more. No more being dismissed by your doctor. No more being told your labs are normal. No more recycled medical advice. No more recycled biohacking advice. No more being told you accept what you know isn't right here. You'll get truth. You'll get clarity. You'll get information you can actually use, tools, strategy, and guidance you can apply right now to take back your energy, your hormones, your metabolism, and your life. Every episode will give you something real, something that moves you forward, something that reminds you that you were never the problem the system was. This is the Thyroid Fixer podcast. This is your turning point. This is where you rise. Get ready. We're about to disrupt everything you thought you knew about thyroid and hormone health. Let's go. I need to talk to every woman who's been told your labs are normal while your body is screaming at you and rebelling against you. Fatigue, brain fog, the weight that will not come off, mood swings, hair loss, feeling dismissed, frustrated and confused. I get it. And that is exactly what why I wrote my new book, the Thyroid Fix. The no nonsense Guide to fix fatigue, fogginess, and fat that won't budge. That just says it all. And it is now available for pre sale. So I need your help to spread the message. I am giving you an ask as my listener and a promise at the same time. If you pre order the thyroid fix, my promise to you is to continue delivering all kinds of free advice, information, content, education, empowerment, because that's what I love to do. Whether it's here in the just fix your thyroid Facebook group or I'm on live, I will give you everything I possibly can if you do me one favor, which will be a favor for yourself as well. And pre order the thyroid fix. Now. This book is not another list of supplements, vague advice. It's not a diet plan. It's not filled with recipes. It is a clear Honest Guide. It is the Thyroid Bible. It is the last thyroid book that you will ever need because it teaches you how to read your own labs. No other book has done that. It teaches you what medication and dose you need. No other book has ever done that. It will help you to understand why you are being misdiagnosed, why you're being under treated and why you can't talk about hormones, weight loss or menopause without talking about the thyroid. I called it Thyroid Bible because like I said, this is going to be the thyroid book of the next few decades. When you pre order, you're not just supporting me, you're telling the publisher. This message matters and it needs to get out to the world and it needs to get into the hands of women who have been ignored for far too long. So will you go to thyroid fixbook.com and pre order a copy of yours today? It'll be shipped to you on May 12th and you will get free entry to our all day live event where I will be there answering your questions live, teaching live and bringing in amazing guests for you to also connect with and ask your questions too. So thyroidfixbook.com pre order yours today. If you are exhausted, gaining weight, you have brain fog, just feel off and you're tired of doctor hopping and wasting money. Listen closely. So many women bounce from provider to provider trying supplements, protocols and then functional approaches that never truly address the thyroid. Months turn into years and you're still stuck feeling like garbage, wasting your precious life. So this is why we offer a thyroid and hormone solution call. It's not a lab review, it's not treatment. It's clarity and strategy to determine whether you're a good fit for working with our clinic. We specialize in thyroid optimization and hormone optimization together because they go hand in hand. You can't do one without the other. You have to do them both. We prescribe in all 50 states and if you become a patient we take care of you from start to finish, testing, treatment, optimization and ongoing support. You don't have months or years to waste feeling this way and you shouldn't have to keep throwing money at people who don't truly understand the thyroid and hormones. So if you're ready for real help, go to Dr. Amy.com that's-r a m I e.com and click book a call in the top right corner to schedule your thyroid and hormone solution call and just let us help you get your life back and be that badass human that you are meant to be, that you deserve to be. So you hear a lot about detox detox pathways, how this relates to your hormones and hormone balance, and you may have heard me even talk about this on past episodes. I've done looking at the Dutch test and my detox pathways as it related to my uterine cancer. But this is a really important subject that we need to break down and you need to understand, especially as a woman, maybe you're on bioidentical hormone replacement therapy and you're wondering, hey, is my body actually utilizing the hormones? Or what about all of these detox protocols that Instagram influencers are talking about? Should I do that? Should I drink my cayenne pepper and lemon juice like Beyonce does in order to detox my liver? Or should I just take handfuls of supplements for my liver because I. I just keep hearing how important it is. Or should I do another gut healing protocol for my digestion? Right. So let's break through the bullshit. That might be the title of this podcast, Break through the Bullshit with my friend and colleague Danny Conway, who is coming on to help unpack this topic as well as, you know, we might even move into peptides, because off air, Dana and I were talking and we share the same belief that you do not jump to a GLP1 peptide to lose weight before you get the foundation down, before you're treating your body like a temple. You don't put a GLP1 or any peptide into a dumpster fire. So, Danny, thank you so much for coming on the show.
A
Absolutely. It's great to be here. Good to see you, too.
B
Good to see you. And I know you deal with this a lot with your, your group, your audience of, of mainly women, I'm going to assume that are looking to obviously improve their health and lose weight. Because, I mean, listen, let's face it, as women, top of mind is whether or not we're carrying an extra five to 50 pounds on our body, we don't really care about optimal health unless we feel good about ourselves. So I know you do a lot with diet culture and breaking through that, and we're going to get to that too, like, like I said with the GLP1 discussion and other peptides. But let's start with what I started talking about. Let's start with that connection, that hidden connection, as you say, between sluggish digestion, which many people have, especially my listeners with hypothyroidism, ostrumos, constipation is, is big detox pathways and hormone balance and really how this actually shows up in everyday symptoms that women Are experiencing. Yeah.
A
And I think it's so important because I often tell clients that their gut is the root cause of their thyroid, many of their thyroid issues. So it plays well with what you're talking about. And when the gut's not functioning, when we can't absorb our nutrients, when we're not pooping daily, when we're sluggish and backed up and bloated and can't sleep, or we're waking up in the middle of the night because we have to go to the bathroom and all these things are happening. Our systems just are not functioning optimally and properly, quite frankly. And I see a huge connection with working on improving digestive markers, sluggish liver detox pathways, and hormone balance before someone ever actually starts working on, so to speak, their hormones. So that just goes to show you that if you work on those body systems, we can digest food better, we can assimilate our nutrients, we can, you know, support our brain health, all these things that are happening. And we can poop regularly. We talk about poop all the time. I'm guessing you do too, since.
B
Oh yeah, we say poop all the time. All the time.
A
And in all of that context, the hormones just start working better. And I have done testing to see, like, okay, I've only done a gut protocol, a detox protocol, used castor oil packs, dry brushing, all these things that seem super woo woo to some people and they're like, does that really work? I'm like, yeah, it does. I don't want clients to be relying on supplements regularly. And you even mentioned that earlier. But that being said, they can be supplemental. And then you get the person to the place where all those things are optimal. You're using castor oil packs and dry brushing as an adjunct to lifestyle factors. And then hormones start working better and then you can go in and kind of target the hormones and you're going to get a much better response.
B
Oh, all day. Yeah. Yeah. I'm happy that you said that because we can obviously give thyroid hormone, give bioidentical hormones balance that optimize people, and those are needed when they're needed. Right. But again, you can't put those hormones, thyroid hormone, bioidentical hormones, or even peptides onto someone who is, like I said earlier, is a dumpster fire. They're not eating properly, their guts a mess. They're not detoxing at all. They're not even doing the basics. They just want, give me the peptide, give me that peptide. Because, you know, Huberman talked about it and it's cool. No, no, you can't have that peptide because you're not even pooping every day. Let's just start there. So. Okay, Danny, where do you start, people? Then how, what should we start with? Take me through the whole detox pathway because there's a lot of people talking about phase one, phase two, and it sounds to me like it starts in our stomach, goes to the liver, kind of walk us through how our body detoxes.
A
So I do have to talk about the foundation because that's how I address everything. So. And I know you do too, but I just have to say for the sake of saying that nutrition is the foundation for everything that we do. If food isn't right, nothing else can be right. So we have to get the foundation first and then it's building on all of that, on that foundation with the systems that we're talking about. So we eat food, we hopefully absorb it. If we're not, you know, if we don't have leaky gut pathogens, other things going on, obviously as food moves through the digestive system, then we're getting into the utilization of nutrients and things that shouldn't be left in the body are going through digestion, detoxification or pooping out, elimination of waste, et cetera, et cetera. So with that being said, things get recirculated if that process isn't happening properly. From toxins to estrogen especially. And then the liver is also responsible for metabolizing hormones, like I said, estrogen, estrogen. But overall, the whole hormone picture, there's a connection with blood sugar, there's a connection with cholesterol, there's a connection with all of these things that those liver detox pathways are affecting. Now to your point of the detox pathways, phase one, phase two, however, whatever way you want to look at it, the body has to take toxins, turn them into water soluble waste, so to speak, so the body can eliminate that through stool, through urine, through sweat, through breath, to make all of these things possible. So the whole function of the body, looking at sluggish liver or sluggish digestion, going back to comprehensive blood work and looking at different markers, pathways, all of the scientific type stuff, that's where I look for patterns. I'm looking for different connections with the hormones and then going in and saying, okay, this is what we're going to do diet wise, this is what we're going to do with strategies, home strategies, Epsom salt bath, infrared sauna, castor oil packs, dry brushing, all the woo woo stuff that people are like, does that work or doesn't work? 100% does work. Self lymphatic drainage is a huge, huge one. And then we can take the supplement protocols, the kidney, liver support, the detox binders, all of those things and sort of up level what's actually happening and get to a point where someone can take down a therapeutic basis, then they eliminate or they finish the supplement. So I always tell clients there should be a start date and an end date. And if you're seeing someone that's like, here's your list of supplements, see you later, you should say see you later to that person because you should always know why you're taking things, what the duration, what the therapeutic benefits are and so on and so forth, and get to a point where the body is going to function optimally and you don't need to rely on those things in order for that to happen.
B
Oh, my gosh, I love that. And that's what we do with people too, is when we're. I can't tell you the amount of people I've sat down with, looked at their supplement list and said, why are you taking this? And they don't know because a past, whatever told them to take it, they went to the chiropractor and, you know, and bought 27. They have no, no idea why they are taking this particular supplement. And that's just a shame because to your point, you should know and you know, I mean, listen, there's always going to be those, and I want to get your opinion on this too, there's always going to be those core supplements that you're not going to get from taking care of yourself. You're not going to get it from the food. Our soil is depleted, all of that. Then maybe you do have to add in like vitamin D. Maybe you do have to add in some magnesium because we know we're magnesium depleted. But, but you don't need 20, 30, 40 different supplements in a day. When you're focused on the basics, which I've been trying to kind of shine a spotlight on more and more on this, on the show, because I think we've gotten too far away, we've gotten too deep into biohacking with Gary Brucka and Dave Asprey, it's like, no, no, no, guys. Hey, remember when you used to talk about basic nutrition and taking care of your bodies? Let's go back there. Yes.
A
So I definitely agree with you. And once a client gets through their, you know, therapeutic protocol, for lack of a better word, I will say, hey, here's some foundational things that I think would be customized for you based on your history and what we've been working on. And I agree, typically some B vitamins, vitamin D, maybe some probiotics, or what I also like to do is have them do things seasonally. So in the springtime, they do a little liver detox support. In the wintertime, they're doing a little bit higher dose vitamin D and maybe some more immune support. In the summertime, maybe they're working on more of the amino acids and things that could help with endurance and workouts and things like that. So that's kind of how I like to do the foundational stuff once they get to where they want to be.
B
Okay, yeah. No, I love that. I love that. All right, so let's start with. We're starting with digestion. So what do you see are the biggest issues? Whether it's behavioral that people are doing themselves or what they're eating, or is it kind of structural or biological that, hey, we're just being assaulted with so many toxins and whatnot in our environment that it's breaking down our gut lining and people are having more gut issues.
A
So in my practice, I had a lot of women coming to me who have been doing the diet pretty dang well for a long time, and they've still yet to kind of get to that next level. And they're still struggling with weight loss and fat loss especially. So that's where, as you know, the comprehensive testing comes in. So we can see where those gaps are and what their underlying causes are that are truly affecting their digestion, whether it's pathogens, whether it's bacterial overgrowth, whether it's enzyme production or I should say, lack thereof, enzymes, HCl, things along that nature. And then kind of fine tuning and figuring out where those missing pieces are to their individual puzzle. It might be as simple as enzymes for one person and hidden mycotoxins for the next person. To your point of toxins and kind of just trying to solve the pieces of the puzzle beyond just, oh, yeah, let's have you remove processed food. Like, we both know that. I'm sure your audience knows that. My audience knows that. So this is kind of like the next step beyond the diet, so to speak. I always want to enforce that because the second I don't, someone's going to say, oh, she just said to use supplements or peptide and she say, say the diet piece. So it's like I'm. I'm always super clear, try to be super clear about that.
B
Yeah, no, I appreciate that tremendously. So does my audience. So simplification is key. Okay. So kind of staying with the gut before we move on. I mean, you know this even from a few years ago, I think it was even more popular than it is now. It's died down a little bit. But everybody went out because Jamie Lee Curtis came on with her Activia yogurt and told the world how important probiotics are. So everybody and their brother is now taking boatloads of probiotics. Whether they're eating Activia, they're buying at a gnc, whatever you. Can you break that myth of why? Number one, taking a probiotic is not the be all, end all answer is not going to totally heal your gut. There's so much more you have to do. And number two, maybe why you shouldn't take just one probiotic for the rest of your life every single day. Yes.
A
So I love both of these questions. You might have to remind me again of both questions because I might go on a tangent sometimes.
B
Okay.
A
I want to talk about the probiotics first as far as the second question, because I also like to. And there's a lot of people say that you, you don't need to do this. And this is a myth. I like to rotate probiotics so we have tons of different strains of bacteria in our gut. If you just take one, then you're only going to get one and you're going to end up with an imbalance with many others. And that's a problem. Can I, can I sidetrack for a second? So let's talk. Okay. Akkermansia. Because this drives me crazy. So there's a lot of Akkermansia probiotics out there that marketing claims, oh, this will help with your GLP1 levels. But here's the problem, and I have proven this because we test for Akkermansia. I have tons of clients that come back high that have asked me, oh, should I take Akkermansia? And guess what? The Akkermansia is elevated because of other issues going on. So we have to actually fix those other issues before we see normal levels as far as that normalization. And that being said, said, if that person just goes out and takes Akkermansia because they think it's going to help their GLP levels because they don't want to take a GLP now, they've actually exacerbated the problem worse because the Akkermansia is elevated as a byproduct of usually mycotoxins or other toxins that are happening that the body is trying to defend against but can't do it on its own. So that's one big gripe and pet peeve I have. But overall, it's really just about rotating those strains of probiotics, making sure that you're getting different, various strains. There's certain strains of Lactobacillus that sort of counterbalance yeast and so on and so forth with these different strains. And so that's where the customization comes in of what was happening before, what did we solve based on the testing that we did? And now what approach of using probiotics is going to be worthwhile and not just literally throwing your money down the drain, because it's actually going to do you some good. So that's kind of my take on the whole probiotic thing. And let's be real, as far as probiotics go, some people feel great on them, other people don't notice anything, and other people actually might cause bloating and other issues. So that's where maybe fermented foods might come in or doing some more leaky gut healing, something like that.
B
Right? Absolutely. And then on the Akkermansia, I have a question for you. If people are high in Akkermansia, or let's just say people don't test and they add on this Akkermansia supplement because they heard that it'll increase their natural GLP1 production, can that actually backfire and diminish or shut down their own GLP1 production?
A
I'm not sure, actually. I can't say yes or no because I'm actually not sure. But, but the issue usually with the higher Akkermansia has more to do with the mycotoxins and other things, pathogens going on that the to defend against. So on one hand, yeah, you might think of it as someone might think, oh, well, it might be good if I take more Akkermansia because that will help the defense. But you're not actually solving the problem and getting rid of whatever toxins or pathogens are creating the problem to begin with, with. So in the long run, even if someone sees a short term all air quote benefit, the symptoms are going to end up coming back. And I see that countless times.
B
Yeah. Okay. Do you want to know the biggest health secret that nobody is talking about? Everything. I mean, everything starts in your gut, but every day your good is fighting the silent war against all the processed foods and the stress and the pesticides and the toxins in the air that you Breathe. And then when your gut's in trouble, your whole body feels it, not just your gut. So here's where it gets a little bit crazy. Most people are spending money on probiotics that don't even work. I see this every day in the practice. Why? Because 99% of those traditional brands die in your stomach acid before they even reach your gut. So you might as well just flush them down the drain. That's what makes Just Thrive spore based probiotic completely different. I have tried it and I am sold. I am totally sold. And when I learned more about it after I interviewed the founder of Just Thrive, my eyes were opened up. I said, this is why I see no change in patients when they throw in a typical probiotic that they got at the grocery store or at the nutrition shop. You need these live probiotic strains in order to do anything in your gut. Just Live is the only one clinically proven to arrive at 100 alive in your gut. That is crazy. 100. And it does something no other probiotic can. It turns your gut into an antioxidant factory, creating protective compounds exactly where you need the most. So that means better digestion, better immunity, more energy, a lot easier weight management. Just Thrive probiotic comes in capsule or berry flavored gummy. So there's an option for everyone in the family. So if you're actually ready to transform your health in 2025, you gotta take this 90 day challenge, love the way you feel, or get a full product refund, no questions asked. So to join the gut health revolution and take control of your health Today, visit Just Thrive.com and save 20 on your first 90 day bottle of Just Thrive Probiotic with the promo code Dr. Amy D R A M I E. So don't forget to check out all their other natural, clinically proven products too, like their newest product, digestive bitters. Focus and memory. Gluten away and more. So that's Just Thrive. J U S T T H R I V E Health H E A L T H.com promo code Dr. Amy D R A M I E. Yeah, that just popped in my head because I know some people can overdo it and then actually shut down their own production. So I just kind of thought about that. Okay, so then on the topic of people using probiotics as kind of a catch, all like, okay, my gut's a mess, I have bloating, I'll take a probiotic, I have gas, I'll take a probiotic, I have acid reflux, I'll take a probiotic.
A
So what people don't usually understand about leaky gut is that what leaky gut means is that you have antigens, foreign antigens, whether it's parasites, yeast, full mold, fungus, bacteria, food antigens, foreign bodies that are leaking from the blood into the gut and vice versa. So a probiotic unfortunately does not close or tighten up those junctions that are allowing that leaking to happen. So with probiotics, they can be beneficial after someone heals and seals the leaky gut. And you know, you have prebiotics and probiotics, which is a kind of a whole other level. But as far as fixing leaky gut, I've really never seen probiotics fix a leaky gut. Now, is there a percentage of people that take probiotics and they might have a resolution or resolve to some digestive issues? Yes, of course there is. It's just like taking digestive enzymes or taking HCl, hydrochloric acid. Those are all things that are in all reality pretty benign to try. And I always say, like, if you try it and it works, maybe you don't need a protocol or maybe that is the answer. But that being said, it just doesn't solve all the problems and it's not going to in the long run, really seal those tight junctions of the gut that are leaking because of whatever is going on in that individual person.
B
Yeah, yeah, that makes sense. Okay, so now where is next in the detox pathways? Now are we moving to the liver after we've digested or where are we going?
A
Yeah, so I think that's, you know, as far as after the digestion goes, the body's assimilated nutrients, so on and so forth, then the body is working to take whatever shouldn't be there anymore, so to speak, turn those toxins from phase one into phase two detoxification, turn those toxins into what we could just call water soluble compounds so the body can safely eliminate them, hopefully via sweat, urine, stool, breath, and then they can be on their merry way. If someone is not sweating regularly, if someone is not pooping regularly, if someone is feeling bloated and food gets stuck and you probably hear a lot of these types of complaints, obviously things aren't moving through the system as they should be. So that's where the lymphatic drainage, the dry brushing, the castor oil packs to support the liver, gallbladder digestion, that whole process can be helpful to get things moving. And then on the hormone side of things, the estrogen metabolism. And we don't want estrogen to recirculate, we Want to be able to have that process continue on a daily basis as needed, versus having the estrogen recirculate backs up. And, you know, we see that beta glucuronidase enzyme elevated on a GI map, so on and so forth with that whole process.
B
Now let's stay there and get a little more granular so the listeners can understand better. So whenever we're talking about a hormone, let's take estrogen, right? Because that is the big one that kind of recirculates. So whether we're producing our own estrogen or we are taking it as a bioidentical hormone replacement, it still has to be processed. So our liver does over 500 metabolic processes. We know that. And that estrogen still needs to move through different detox phases and detox pathways. That's what we see on a Dutch test.
A
Right.
B
So can you explain to the listeners, like layman's terms, bare bones, just what exactly is happening to that hormone as it moves along the pathway? And then what happens if someone, let's say they do have a thyroid problem, they are experiencing constipation, they only poop every other day or every third day or every fourth day birthday, God forbid, what's happening to that hormone in their body, that it's literally being recirculated.
A
So the hormone itself gets recirculated back into the digestive tract ultimately. So then we see an elevation in that enzyme, like I just mentioned, the beta gluc.
B
Okay?
A
And so with that being said, when the estrogen goes through that process, we want that process to be continuing. And this is especially relevant if I could just kind of add in, because I work with a lot of Carnivore clients as well. And Carnivore diet, it's a great elimination diet for various reasons, but there's a lot of influencers out there saying, oh, it's completely normal to poop once a week on Carnivore. No. Whether or not you're Carnivore, you should be pooping every single day. And I have to work on this with clients all the time because they're not going. And so they're getting that recirculation. So back to the question of the estrogen is moving through these pathways. We are hopefully going to have it come down the 2oh, and maybe some down the 16oh pathway and not the 4oh pathway, because of the way that the body is processing estrogen through these pathways. And one is more degenerative than the other two. And all of that being said, once it goes through that process and the body is doing the proper detoxification, methylation things are eliminating. That whole process should be happening on a regular basis. And when we see every other day, every three days, make my head explode. When someone says once a week, it's like, no, we need to get all of that working properly before we do anything else. And I'm going to sidebar for a second because we'll probably get to it, as you said. Then someone takes a GLP and they complain that they have constipation. Yeah, you're just exacerbating the problem. So this is why when, like when we were talking about in the beginning when I said, you know, the foundation has to work, nobody should be using peptides if they're not pooping properly. Those peptides aren't going to solve that problem. So all of these little nitty gritty, literally body systems that should be functioning optimally need to be close to that. And I say close to because I do feel that there's a place for peptides to help people get to that optimal level. I don't want to be completely like remiss about that. But this other stuff is like foundational. I'm not going to say as important as nutrition, but I'm going to say like pretty dang close kind of thing.
B
Oh yeah, no, I, I agree. Because again, let's talk about what the symptoms are when a woman does not properly detox her estrogen. So we hear women talk all the time about estrogen dominance and sometimes you'll actually hear a woman diagnose herself with estrogen dominance when she doesn't have estrogen dominance. But you know, it's like that's a buzzword, but yet it's real at the same time. Now I know, you know, personally, obviously I've gone down multiple rabbit holes since I was diagnosed with uterine cancer that if you're not properly metabolizing, detoxing your estrogen and that recirculates that estrogen dominance can equate, and you mentioned it already, push down that 4 and 16OH pathway, which is a more growth producing estrogen pathway. So essentially, even though horrible hormones don't cause cancer, excess estrogen can be problematic in the cancer realm. We'll say that there's not a causational effect, but it can become problematic. But outside of the big C, what are the symptoms that women might experience if they're recirculating their estrogen?
A
Okay, I love this question. And first I want to talk also about estrogen dominance. And say many, well, estrogen dominance is really real with especially seeing it on lab tests, symptoms like I'm about to talk about, one of the bigger drivers of estrogen dominance is inflammation. And so it's important that there's. People understand there's a connection there because a lot of women just think, oh, if I, and I literally got asked this question four times in the last week, if I just add more progesterone, is that going to fix my estrogen dominance? So on paper, on a lab test, sure it might. And there's probably a handful of women out there that if they just increase their progesterone that they're taking, their symptoms might be eliminated. But that being said, various symptoms can be water retention, bloating, fatigue, inability to lose weight, brain fog, inability to build muscle, therefore having a super hard time with weight loss and fat loss. So I say weight loss and fat loss loss because they can be different. I see them as being different. And some women do need both and some women just need one or the other kind of thing and we can rabbit hole that later. Sorry, but those are just some of the main things I see. And I think like the water retention, bloating, constipation, fatigue, brain fog, and then the connection to weight loss and fat loss, like those are the, some of the big ones.
B
Yeah, no, I'm glad you mentioned that. And then I don't know if this is a really, really bold statement to make or not, but I'm just kind of piecing this together in my mind as you're talking. If someone is taking a GLP one or GLP, we know there's 1, 2, 3. If someone is taking a GLP and they're taking enough to slow their digestion to where now they're not pooping, they do experience that slow gastric motility, then that is going to set you up for, for all of the estrogen dominant symptoms that Danny just mentioned, in addition to possibly increasing your risk of cancer. I mean, I know that's a big, big, big, big, big, big, bold statement tied to GLP1s and everybody listening is like, oh my God, no, don't tell me. I'm not saying GLP1s cause cancer. I'm saying if you are not pooping and you are not being properly guided, you're taking too much, you're pushing the limits with it, you're not doing the micro dosing with someone that knows what they're doing, just saying it could and
A
cycling them and stacking them properly and all those things are connected. But I completely agree with you. And it's not something that's going to happen overnight, but when you have this series of things happening or you have the person, here's another one, you have the person that has been constipated for 10 plus years, then you don't address all these detox things that we're talking about and they're not sweating regularly and they're not doing all these things and you go right to that as a, they think it's a solution and then they just end up again down the rabbit hole, more problems, more issues, recirculating the estrogen dominance, inflammation, etc. Etc.
B
Now what? And I know we kind of like not bash supplements, but we don't want people just taking them willy nilly. What supplements do you do you like to help people maybe with their gut or maybe with this estrogen detox pathway? Do you like calcium D glucarate? Do you like D like what do you like to use?
A
So I actually do not like dim and I never use dim because it can lower overall total estrogen. And most of the women I work with already have low estrogen and they're having issues because their practitioner told them that, oh, if they have estrogen, if they take estrogen, they should just take dim. Also, it's like, no. So to answer your question, I like to support the actual detox pathways through amino acids, liver support type, herbs, binders, so things that are specifically helping with the liver detoxification, but not so much with the estrogen level. Now side note, if that B glucuronidase is elevated, sometimes I will use calcium D glucarate. But that being said, just as a general rule, when I first start someone out on a liver detox protocol and we're addressing that stuff to get things moving prior to moving into gut cleansing and hormones and all of that, it's the liver, kidney support type stuff, it's the binders, it's the foundational nutrients. Sometimes I'll use bioregulate liver and kidney bioregulators as well. And all of those things again, 60,000 foot view of supporting the liver, detoxification, moving into digestion and then kind of going from there as the protocol progresses.
B
Okay, I love it. I love it. Okay, so now you mentioned peptides. We mentioned them in the beginning and how we don't use GLV ones, we don't use other peptides too. So not just the GLPs, other peptides on a dumpster fire. So let's expand on that, how do you like to incorporate? Well, first of all, what do you see from women? Are they coming into your world on a boatload of peptides? They don't know what they're doing or what they're taking and they're taking too many and then what do you like to actually use and how.
A
So I get both. I get the women that have tried whatever random protocol they saw on social media and they're like on this list of things they're like, but this isn't really working or it's not really doing what they told me. Yeah, because if you do a bunch of random peptides you're going to get a bunch of random results.
B
Right? Right.
A
Usually means no results. Okay, so there's that. So then I get the women that are like apprehensive because they actually are so confused by what's out there and they don't know what the best step by step approach, how to stack, how to cycle all of these things. So I like to approach again this is, let's just say all of the body systems are working almost optimally. Like I said, I think there's room for using peptides to get to the optimal level. But almost people are pooping regularly, they're eating properly, they're resistance training, they're sleeping. So we're on the same page there. Then I like to move into cellular health and anti inflammatory type stuff. So you know that would be like your mot c your Gemini name is okay to name peptides. So that would be like your MOT C formally SS31 looking at things like TB500BPC to look at you know, inflammation and increasing angiogenesis and all these things that can really support, support the body from a foundational level. Even like with bpc, even if someone doesn't necessarily have an injury per se, but again cellular optimal health. And then looking at okay if their goals are weight loss and fat loss, if they're not into GLPs, that's fine. Then there are other peptides to use. Five amino slope. Those are some of my favorite ones. They are going to go the GP route. Then it's looking at okay, low, I'm into the lowest microdose possible because when everything else is functioning you don't need a high dose number one. And I actually tell clients like since my so I work with a lot of women who are chronic undereaters in their history so I don't want something that's going to just come in and suppress their appetite. My goal is to initially Customize their macro so they get to a point where they're. My thing is eat more, way less, not eat less, way less. So I want to say again, eat more, way less.
B
Love that.
A
More, way less. Right. And that was like, for me, like years ago, I had to teach myself, okay, I'm never going to get my body composition goals if I don't eat enough. And so that's kind of like that was my journey too, after all the chronic dieting that I, I did. So circling back to the question is looking at, you know, if someone is going to use a glp, I want them on super micro dose. I want them to be doing all the other things. When they're doing all the other things. Correct. You don't need a lot of peptides because the peptides are just enough to, and I kind of hate this word, I don't like the word amplify, but people understand what that means. So it just sort of assists with the whole process, but it doesn't create a reliance on the peptide to do the results for them. The peptides aren't going to lift the weights. The peptides aren't going to do the food. The peptides aren't going to make them sleep. And they could all help, but they're not going to fix the foundation of all of that. And with that being said, it's also, you know, as far as like just kind of overall, I don't like to promote appetite suppression. I like to call it appetite balance. And I do respect the women especially who need to have help with their food noise. I totally understand that. But again, there's a difference and a fine line between helping with food noise and suppressing appetite. And we need to stay at the line of helping with food noise and not cross over to appetite suppression.
B
Yes. Oh, I love you for that because I think, you know, just like we're in this rapid changing world on social media and AI and it's like you can't keep up. I also feel like it was just yesterday that we were talking and educating people on this amazing GLP that's come out and how you can use it, how you can use it properly and, and the microdosing aspects to just. We are now in a show with these GLPs where everybody and their brother and sister are using them. I used to call them the Beverly Hills soccer mom drug of choice for weight loss, but, right. Everybody's using them, they're using them wrong. We're seeing all these side effects and it's like, wait a minute, we started off back here, and I'm talking back here is like a few months ago, talking about the benefits, and y' all have taken it to extremes, and now we have to reel everything back in and go, wait a minute. If you use these properly, there are benefits, but there are too many people, to your point, suppressing their appetite, losing their muscle, losing their facial fat, looking 20 years older than they are. Yes. Even celebrities. And we've. We've just gone astray. We've gone astray with the GLPs, and we need to reel it back in.
A
I totally agree. And you know, I have a lot of unpopular opinions, and for sure, I've been criticized on a lot of things and I don't really care, honestly. Like, my. In fact, I do words for every year. My word for this year is truth. Because, like, at the end of last year, I was just kind of feeling like I, you know, have so much to say. And sometimes I find myself, truth be told, like, maybe I shouldn't say that because, you know, X, Y, Z. But I always say, like, unpopular opinion kind of thing. And I think that people think like, oh, like, here's the problem is that many people that are also criticizing aren't bothering to understand what else is happening when someone uses, uses, whether it's a GLP or another peptide as a messenger in their body to help sort of direct the body on how to do things and how to re attach the signaling that's happening. So it's a signaling molecule to help the body do what it's supposed to do. And I feel like it's unfortunate that, you know, let's face it, media, it's unfortunate that people just listen to the regular media and they're not willing to learn or understand what's happening, actually happening.
B
Yep. That's so true. That is so true. Now, I love you and I love how you challenge the norm and you challenge the mainstream thinking. And you really do take these women, mainly over 40, right, who have yo yo dieted their entire lives. I was there. I was there. I mean, you know, I competed. That's a. That is a Yo yo diet. Over and over and over again. Essentially.
A
It is.
B
And I love your motto of. Of eat more, way less. So, Danny, you are doing massive things in this world. I know after hearing this episode, my ladies are going to want to follow you and check out your stuff and possibly join your community and join you. So can you tell everyone where they can find you and find more information? I know you're doing Instagram lives on the regular I'm going to be on yours very, very soon, so tell everybody where they can find you.
A
Yeah, absolutely. So my Instagram is Danny Conway official, so I do a lot of Q and A in my stories, myth debunking in my posts. I have a monthly community called the Wellness Collective where we go beyond diet. We talk about hormones, we talk about peptides, we talk about all of the things that women have questions about that they're not getting the answers that they need to progress with their goals. And then I have my weight loss accelerator program as well. So that's a program that I run quarterly and my website is nutrition the natural way.com and I do work with clients one on one as well.
B
So beautiful. Well we will put all of that down in the show notes so people can easily click and find you. Danny, thank you so much for your time today. I've loved this discussion because you and I are both on the same page and we're about truth and about just no bs making it real for people so they can cut through the noise. So I appreciate you and I appreciate what you're doing for women everywhere.
A
Awesome. Thanks for having me. It was great.
B
And thank you all for listening. Share this episode with ladies out there who are under eating, they're overtaking GLPs or they're taking probiotics every single day. And if that's you then you need to re listen to this episode and check out Dani and join her group and maybe work with her one on one. So until next time, thank you so much for listening to the show. The information shared on the Thyroid Fixer Podcast is intended solely for informational and educational purposes. It is not a substitute for professional medical advice, diagnosis or treatment. Always consult with your physician or other qualified healthc care provider with any questions you may have regarding a medical condition, treatment or before making changes to your healthc care regimen, including medications, supplements or other therapies. Use of the information provide provided in this podcast does not establish a doctor, patient or client provider relationship between you and the host or between you and any other healthcare professionals featured on the show. Any medical opinions or statements made by guests are their own and do not necessarily reflect those of the host or affiliated parties. Statements regarding dietary supplements or health related products mentioned in this podcast have not been evaluated by the fda. These products are not intended to die, diagnose, treat, cure or prevent any disease. Some episodes of the Thyroid Fixer Podcast may include sponsorships or affiliate links. The host may receive compensation for discussing or promoting certain products or services. Any such sponsorships or affiliations will be clearly disclosed during the episode. All opinions expressed are those of the host or guests and do not necessarily reflect the views of any sponsors. The inclusion of a product or service does not imply endorsement by any health care professional featured on this podcast.
Episode 610: Digestion, Detox Pathways and Hormone Balance and Why You NEED to Poop Daily
Host: Dr. Amie Hornaman
Guest: Dani Conway
Date: March 6, 2026
This episode dives into the foundational role of digestion, liver detox pathways, and daily bowel movements (“pooping”) in achieving hormone balance and thyroid health. Dr. Amie Hornaman and guest Dani Conway cut through trends and myths surrounding detox protocols, probiotics, hormone therapies, and peptides, with blunt truth and actionable advice, especially for women struggling with hypothyroid symptoms, constipation, and weight loss resistance. The key message: You can't optimize hormones, metabolism, or add advanced therapies like peptides until the basics—gut health and detoxification—are working.
“Nutrition is the foundation for everything that we do. If food isn't right, nothing else can be right.”
— Dani Conway [00:00 and 11:41]
“Oh, yeah, we say poop all the time. All the time.”
— Dr. Amie [09:43]
“Their gut is the root cause of their thyroid, many of their thyroid issues.”
— Dani Conway [08:38]
“You can't put those hormones, thyroid hormone, bioidentical hormones, or even peptides onto someone who… is a dumpster fire. They're not eating properly, their gut's a mess… They're not even pooping every day. Let's just start there.”
— Dr. Amie [10:33]
“There should be a start date and an end date [for supplements]. If you're seeing someone that's like, ‘Here's your list of supplements, see you later,’ you should say see you later to that person.”
— Dani Conway [13:38]
“I can't tell you the amount of people I've sat down with, looked at their supplement list and said, why are you taking this? And they don't know because a past, whatever told them to take it.”
— Dr. Amie [14:43]
“If you just take one [probiotic], then you're only going to get one and you're going to end up with an imbalance with many others. And that's a problem.”
— Dani Conway [19:28]
“Whether or not you're Carnivore, you should be pooping every single day... They're getting that recirculation.”
— Dani Conway [30:14]
“If you're not properly metabolizing, detoxing your estrogen... that recirculates, that estrogen dominance can equate, and ... push down that 4 and 16OH pathway, which is a more growth producing estrogen pathway.”
— Dr. Amie [32:34]
“You don't put a GLP1 or any peptide into a dumpster fire.”
— Dr. Amie [06:36]
“I actually do not like dim and I never use dim because it can lower overall total estrogen... I like to support the actual detox pathways through amino acids, liver support type, herbs, binders...”
— Dani Conway [37:13]
On the importance of daily elimination:
“Whether or not you're Carnivore, you should be pooping every single day.”
— Dani Conway [30:14]
On supplementation confusion:
“I can't tell you the amount of people I've sat down with, looked at their supplement list and said, why are you taking this? And they don't know because a past, whatever told them to take it...”
— Dr. Amie [14:43]
On root causes and never skipping steps:
“You can't put those hormones, thyroid hormone, bioidentical hormones, or even peptides onto someone who… is a dumpster fire.”
— Dr. Amie [10:33]
On real causes of estrogen dominance:
“One of the bigger drivers of estrogen dominance is inflammation... various symptoms can be water retention, bloating, fatigue, inability to lose weight, brain fog, inability to build muscle, therefore having a super hard time with weight loss and fat loss...”
— Dani Conway [33:43]
On peptide popularity and the risks of skipping steps:
“We have just gone astray. We've gone astray with the GLPs, and we need to reel it back in.”
— Dr. Amie [44:33]
On health truths and “no BS” advice:
“My word for this year is truth... I always say, like, unpopular opinion kind of thing. And I think that people think like, oh... but [they] aren’t bothering to understand what else is happening when someone uses, whether it's a GLP or another peptide as a messenger in their body...”
— Dani Conway [44:33]
Slogan:
“Eat more, weigh less.”
— Dani Conway [41:34]
If you’re struggling with constipation, “hormone imbalance,” or frustrated weight loss, start with your gut and daily habits. The magic bullet doesn’t exist, but the fixable basics do.