← The Thyroid (and Hormone) Fixer Podcast: Thyropause, Menopause, Metabolism and How to Fix It
The Thyroid (and Hormone) Fixer Podcast: Thyropause, Menopause, Metabolism and How to Fix It
619. GLP-1s and Your Thyroid: What Ozempic Is Really Doing to Your Hormones
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I'm a thyroid specialist and what I'm seeing in real patients is concerning. Not because these medications are evil, but because they're being used without understanding the metabolic consequences. So before you start one, or if you're already on one, you need to hear this now. GLPs are not the villain, but using them without monitoring your thyroid is reckless. Welcome to the Thyroid and Hormone Fixer Podcast. If you've been told everything is fine, but you're gaining weight despite all the right things, struggling with brain fog, mood swings, low libido, or feeling like a stranger in your own body, you're in the right place. I'm Dr. Amy, the thyroid Fixer, and I want you to know right now, I see you, I believe you, and you don't have to figure this out alone anymore. We're going to do this together. But I'm also not here to play nice with bad medicine or empty promises. This show is meant to disrupt the entire health space. We're going to challenge the status quo, connect all the dots other providers miss, and give you real practical science back, tools you can use. Today. You're not going to get any more recycled biohacking advice, just truth, strategy and hope. Let's get you back to feeling like the badass human you're meant to be. I need to talk to every woman who's been told that your labs are normal while your body is screaming at you and rebelling against you. Fatigue, brain fog, the weight that will not come off, mood swings, hair loss, feeling dismissed, frustrated and confused. I get it. And that is exactly why I wrote my new book, the Thyroid Fix. The no Nonsense Guide to Fix Fatigue, Fogginess and Fat that Won't Budge. That just says it all. And it is now available for pre sale. So I need your help to spread the message. I am giving you an ask as my listener and a promise at the same time. If you pre order the Thyroid fix, my promise to you is to continue delivering all kinds of free advice, information, content, education, empowerment. Because that's what I love to do. Whether it's here in the Just Fixture Thyroid Facebook group or I'm on live. I will give you everything I possibly can if you do me one favor, which will be a favor for yourself as well. And pre order the Thyroid Fix. Now. This book is not another list of supplements, vague advice. It's not a diet plan. It's not filled with recipes. It is a clear, honest guide. It is the Thyroid Bible. It is the last thyroid book that you will ever need because it teaches you how to read your own labs. No other book has done that. It teaches you what medication and dose you need. No other book has ever done that. It will help you to understand why you are being misdiagnosed, why you're being under treated, and why you can't talk about hormones, weight loss or menopause without talking about the thyroid. I called it Thyroid Bible because like I said, this is going to be the thyroid book of the next few decades. When you pre order, you're not just supporting me, you're telling the publisher. This message matters and it needs to get out to the world and it needs to get into the hands of women who have been ignored for far too long. So will you go to thyroid fixbook.com and pre order a copy of yours today? It'll be shipped to you on May 12th and you will get free entry to our all day live event where I will be there answering your questions live, teaching live, and bringing in amazing guests for you to also connect with and ask your questions too. So thyroid fix book.com pre order yours today. If you've ever walked out of a doctor's office being told your labs are normal but you're exhausted, gaining weight, foggy, frustrated, then this is for you. Being told you're normal doesn't mean you're optimal, and it definitely doesn't explain why you still feel like something is wrong and feel like garbage. That's exactly why we created the Fixer Lab Test plus Consult. It's affordable, often less than ordering labs on your own from places like LabCorp or Ulta, and it includes comprehensive thyroid and hormone testing plus a full hour long consultation with one of my highly trained team members. We walk you through your results line by line and explain exactly what they mean for you so you can finally understand what's going on in your body and what your next step should be. So if you're done being told that you're fine and you're ready for real answers, then go to fixerpowerlab.com that's F I X E R P O w r l b.com and get some help that you need. If you're listening to this episode but you have not yet listened to episode 618, the Dark side of GOP's nobody warned you about, then please go back and listen. Because in the very beginning of that episode I explained that these two podcasts are not about fear mongering. They are not a hard line in the sand trying to scare you away from GLPs. These are meant for education Information empowerment. You take this information, swirl it around in your brain, like I said in the last one, and then decide. Because if you don't have all of the pieces of information, then you can't make an informed decision. And this is exactly what influencers or social media pushers will do. They will take one side and then drive it down your throat as dogma so that you believe it. And GLPs are very polarizing. I mean, you might have one camp that is shouting from the rooftops that you're injecting snake venom and that it's going to cause every cancer under the sun and that you're going to go blind. Okay. For the record, haven't found that data. Okay. And then on the other side, you have the group that is just screaming what a life changing medication this was. And for them it is, it is, it is. I'm hoping they're using it right and that they're not losing their hair and their muscle and not looking 20 years older, but it's changing their life. I'm in the middle, I'm like, listen, I'm microdosing gops. We use it in the clinic. I know they're kind of pricey, they're not really for everybody. So I do believe we need kind of a middle of the road answer to our obesity crisis. Still believe that. That's T2. Just saying. I think $44 a month is way, way, way more doable for the majority of the population than hundreds or thousands of dollars per month. But take the information, Decide for yourself. Weigh the pros, weigh the cons. Like weigh it all. In this episode. Yes, I'm going to the flip side of what these GLPs can do badly to your thyroid. Now, again, in the book the Thyroid Fix, I have an entire chapter on GOPs and, and their benefits and how they're a biohacking tool. Because I myself haven't been able to lower the amount of T3 medication that I take. Not again. That there's a gold star given out for. Oh, I lowered my T3 dose by 50 micrograms. No, I'm not going for a gold star because there isn't one. What I'm going for is the muscle preservation. So I'm going for the muscle preservation by trying to lower my T3 dose. Because we do know what we know. What I mean by that is that T3 doesn't decide between fat and muscle. It will burn both. And that's just the good with the bad that we take. Just like GLPs will burn both muscle and fat. We know that now, 40% lean muscle, 60% fat. So if I can pull back on my T3 dose to the lowest possible dose, that still runs my body, which now for me is 50 micrograms twice a day. I was on 75 twice a day, so I'm on a pretty hefty dose already. So it doesn't matter whether you lower it by 25, 50 or 5 micrograms. If you can pull it back a little bit, then we all have a better chance at muscle preservation. But we have to find that balance where we pull back but we don't go into hypothyroidism. So, yes, I was able to pull back a little bit on my T3 dose for muscle preservation, but I still microdose. I also shared on the last episode my horror story of what happened over the last couple of weeks after accidentally, not overdosing, but large dosing, macro dosing, my glp, that wasn't fun. So I present all of this to just share with you both sides, so that you can make educated, informed, empowered decisions. So before you go into this one, go to the last one. Listen to that. And please note that yes, yes, yes, we can use GLPs to help your thyroid, to reduce inflammation, to reduce the amount of thyroid hormone that you need to possibly even impact your antibodies. But it has to be done the right way because there's also this that can happen. Everybody's talking about the weight loss, but almost nobody is talking about what these GLPs do to your thyroid. I'm a thyroid specialist and what I'm seeing in real patients is concerning not because these medications are evil, but because they're being used without understanding the metabolic consequences. So before you start one, or if you're already on one, you need to hear this now. GLPs are not the villain, but using them without monitoring your thyroid is reckless. So before any of you come after me and say, wait, Dr. Amy, you said that GLPs are fantastic and that they could be a miracle. Yes, again, I said this in part one, I'll say this in part two. GLPs are fantastic. If you are a type 2 diabetic, if you truly are struggling with obesity, you cannot lose weight no matter what you do, or you are one of the rare people out there that was born with a GLP1 deficiency where your body just doesn't produce it. These medications are life saving and life altering, but we have to understand who should be taking them, and we need to understand what they do to our bodies. So GLP1 medications mimic a hormone that your body already makes after you eat glucagon. That hormone tells your brain that you're full, slows digestion, stabilizes blood sugar, and ultimately reduces appetite. So people naturally eat less, sometimes dramatically less. If you've tried a glp, if you've taken a little bit too much, or if you are on a higher dose of a GLP and your appetite is affected, you need to listen to this. As we said in part one, some of that weight loss is impressive. It can be life changing. But some of that weight loss also could be muscle and it can start affecting your hair. That's the bottom line. So these drugs don't just reduce fat, they're reducing your food intake. They're reducing your energy availability. They're reducing signals to your entire endocrine system. And we know the thyroid is like the canary in the coalite. It is extremely sensitive to energy available in the body. Like, is there enough energy here for this body to run from head to toe? The thyroid runs the show. And it's very, very sensitive. So when calories drop quickly, your body doesn't just say, oh, yay, there's less calories, let's grab some fat from storage and burn it. No, your body says, oh, there's less calories, let's hold on to the fat and go into survival mode. And this is going to involve your thyroid. It's going to Involve increasing reverse T3, decreasing free T3, downregulating your metabolism. So, yeah, you might still be losing weight on paper and then destroying your metabolism in the process to where, when you come off of that drug, the weight is going to come back on and then some. And it's not because you're going to eat more. Everyone thinks that the weight regain or the rapid weight onset after stopping a glp, it's because, oh, a person's just eating more. No, no, that's not it. It is because you have successfully shut down your metabolism and downregulated your thyroid while you were on the glp. Now you're coming off of it and your thyroid is still in the toilet and your metabolism is still in the toilet. So this is why rapid weight loss hits the thyroid so hard. So your thyroid controls your metabolism. Can we all agree on that? We know that, right? We know that by now that the thyroid is the master regulator of your metabolism. But ultimately your brain decides how much thyroid hormone activity your body is allowed to use. So your brain senses that food intake is dropping here. Is there a famine going on. Is there something that we should know? Well, you know what? Just in case, just in case there was a famine, we're going to slow down this person's metabolism to conserve energy, because better safe than sorry. So this shows up as a lower conversion of T4 into active T3. If we're not converting our T4 to T3, what are we converting it to? Reverse T3, the brake pedal, the antithyroid hormone, the hormone that puts us in survival mode and in hibernation mode like we're a bear in the winter. Less energy expenditure, increased fatigue, cold intolerance, hair changes, and plateaued weight loss. There's another effect that we're going to be talking about with GLPs, and that's basically when your body adapts to that dose. So it's adapting to that dose of the GLP that you're taking, which is why most people have to continually increase it. But there's a metabolic adaptation happening to where your metabolism is down, regulating to a lower set point. So if your baseline metabolism, your BMR used to be. Before you started taking a GLP, it used to be 1200 calories a day. Now it's down to 900 calories a day, 800 calories a day. This is baseline metabolism. This doesn't include movement, walking, exercise, anything like that. This is your basal metabolic rate, as if you were lying in bed all day long. How many calories would you burn? Just breathing, just living. So your baseline metabolism actually down regulates in response to a lower caloric intake. Now, this effect is not specific to GLP1 drugs or GLPs in general. It happens with any type of aggressive weight loss. So even back in the days of fen phen. Oh, my gosh. Even back in the days of Jenny Craig and calorie counting and we tried to stay under 1200 calories, our metabolisms would downregulate to match the energy input into the system. Years ago, Dr. Jason Fung had an amazing presentation where he literally used a power plant as an example. I love this, I love this explanation where he shared, okay, you have a fuel plant, and this fuel plant is regularly getting in, let's say, 5,000 tons of fuel every day. So it's burning 5,000 tons of fuel every day. It's coming in, it's burning, it's coming in, it's burning, and then it's going out as energy or whatever, gas, fuel, whatever. So we're not worried about that part. We're just talking about the, the energy and, and the burning. Right. And Then all of a sudden, there's a shortage and. And now, oh, my gosh, only a thousand pounds of coal or whatever is coming into the plant. So we have to downregulate our workflow at the plant. We can't burn 5,000 tons of fuel anymore. It's 5,000 tons of coal. We have to shift gears, ramp down, downregulate, downshift, now we're only burning a thousand pounds of fuel. Same thing happens with your metabolism. It's going to downregulate. Jason Fung also, all those years ago, I'll never forget this study that he mentioned. There was a study where I'm going to try to get this, all the facts straight. I should have looked it up. But I'm just going from memory because it just kind of came into my head right now where they actually took, I want to say, prison inmates because they could control them and they could control how much food actually went into their bodies, right? So they took these prison inmates and they wanted to test to see what their metabolisms would do if you increase calories. So they brought them up to like 10,000 calories a day. 10,000 calories a day. Try to go eat that. It's hard. You probably won't. 10,000 calories a day. So what ended up happening is their metabolisms actually shifted upward. So even a couple of the inmates who gained weight eventually lost that weight because their energy plants, their bodies started adapting to the 10,000 calories coming in every day, and it was burning 10,000 calories every day. So our bodies do adapt to the amount of energy that we are putting in. It will adapt all day long. So when we are taking in less calories, our bodies adapt that way as well and downregulate. So GLP1s can make that aggressive weight loss effortless, which means that people can slip into conservation mode, hibernation mode, without even realizing it, because they're just focused on the scale. They're like, woo, my weight's going down, my weight's going down. But they're not realizing what's going on internally to their thyroid, to their metabolism when they're doing it. So the fastest way to wreck your thyroid is rapid weight loss without the right support. So here's why thyroid patients are especially vulnerable. If your thyroid is already struggling, this matters even more. So at least if you are one of our patients, you are getting optimized or you are optimized, you're going to have a leg up, you're going to be in a much better position to now incorporate NAGLP at a microdose with this important nutrients than Susie Q who's starting off with a rep. Thyroid hormones in a low state. Possibly her thyroid has already low free T3 elevator reverse T3. Well, I mean for her the GLP isn't even going to work. I had a patient like this. I talk about her often. She came into us with an A1C of an 11.9. She was a full blown type 2 diabetic. She was on a GLP for a year and a half. It did not budge the scale. She lost no weight whatsoever. Thank God it was actually covered by her insurance and she wasn't paying one of those IG influencers or pop up clinics that are selling GLPs. She was actually getting it covered by her insurance because she was a full blown type 2 diabetic. It was not working. It was not working. Nothing was moving well. It was because her thyroid was in the toilet shell was on T4 only her reverse T3 was elevated. Her free T3 was low. Once we fixed her thyroid then the GLP started working. But if you are going into using a GLP1 with your thyroid in the toilet, you are going to waste money and you could actually compromise your metabolism after. Do you want know the biggest health secret that nobody is talking about? Everything. I mean everything certs in your gut. But every day your gut is fighting the silent war against all the processed foods and the stress and the pesticides and the toxins in the air that you breathe. And then when your gut's in trouble, your whole body feels it, not just your gut. So here's where it gets a little bit crazy. Most people are spending money on probiotics that don't even work. I see this every day in the practice. Why? Because 99% of those traditional brands die in your stomach acid before they even reach your gut. So you might as well just flush them down the drain. That's what makes Just Thrive spore based probiotic completely different. I have tried it and I am sold. I am totally sold. And when I learn more about it after I interviewed the founder of Just Thrive, my eyes were opened up. I said this is why I see no change in patients when they throw in a typical probiotic that they got at the grocery store or at the nutrition shop. You need these live probiotic strains in order to do anything in your gut. Just live is the only one clinically proven to arrive at 100% alive in your gut. That is crazy. 100% and it does something no other Probiotic can. It turns your gut into an antioxidant factory, creating protective compounds exactly where you need the most. So that means better digestion, better immunity, more energy, a lot easier weight management. Just Thrive Probiotic comes in capsule or berry flavored gummy. So there's an option for everyone in the family. So if you're actually ready to transform your health in 2025, you gotta take this 90 day challenge, love the way you feel, or get a full product refund, no questions asked. So to join the gut health revolution and take control of your health today, visit justthrive.com and save 20% on your first 90 day bottle of Just Thrive Probiotic with the promo code, Dr. Amy D R A M I E. So don't forget to check out all their other natural, clinically proven products to two, like their newest product, digestive bitters. Focus and memory. Gluten away and more. So that's Just Thrive. J U S T T H R I V E Health H E A L T H.com promo code Dr. Amy D R A M I E Because even if you're listening to me now, going, well, I'm on T4 only I didn't optimize my thyroid. I started GLP1 because I saw all the influencers doing it and all the celebrities were doing it and I lost weight. Okay, good. Talk to me after you come off of that. Talk to me. When big farmer takes it away from you, you can't get it anymore. What are you going to do? What are you going to do when you gain all that weight back and then some because you downregulated your thyroid, you increase your reverse C3, you put your body in the survival hibernation mode. Now you have no metabolism and you have no access to your drug. You have no way to get it. What are you going to do? Something to think about, honestly, because we don't know the future of GLPs. The truth is, is that Lilly and Novo are the two big pharma companies coming after the compounders. They've already shut it down on the research sites. Right. Will there be a black market for glpc? Yeah, there absolutely will be. But that's how you're going to have to get. You have to go to the guy at the gym who's selling them out of the back of his car. And that's how you're going to get your GLP is you don't know what the hell's in that bottle, that's for sure. But the reality is we Cannot put our head in the sand and pretend like we're going to have access to these medications for the rest of our life. Because we're not. Not if big Pharma has their way. You're not going to be able to get it from a compounding pharmacy anymore. You and you're already not able to get it from the research pharmacies, from the research peptide sites. So it is something to think about that if you have to go cold turkey. Where will your metabolism be? What is your baseline metabolic rate? Is it lower now? Do you have reduced mitochondrial function? Do you have hormone imbalance? Did you lose muscle which automatically makes you less metabolically active? Do you have chronic inflammation? So when calories drop sharply, that's a problem. Your whole system has less resilience. And then there's another issue. Medication changes. The need for medication change. If you are already on thyroid medication. So if you're on thyroid medication, you lose a significant amount of weight, your dose may no longer be appropriate. You could become over replaced possibly. Now if you're on T4 only, probably not. You probably just have an elevator reverse T3 and you being on a GLP, just push that reverse D3 higher. Which means my God, you just need to come to us. You need to book call, you need help right away. Just, just right away. Don't even worry about being over medicated. But if you are on T3, if you're on lyothyonine cytomel, natural desiccated thyroid, you might need a downshift in your dose. This is what I noticed. I have been on the same dose of T3 now for about 20 years. I used to take 75 micrograms of lyothyrenine twice a day which equals 150 micrograms of T3. When I started using a GLP and I started microdosing it in the right way. Not back when I talk about trying my glp, trying Manjaro when it first came out and I lost muscle. That's in part one. You can go back and listen to part one to hear that story. This is now at a micro, micro micro dose. I am talking oh and dare I say doses online. Oh my God. People are gonna themselves but okay, here's my dose of tersempatide. I was and kind of slash have been. I always play around with my dose but was have been taking about 0.5 milligrams. 0.5, not 5, not 2 5, not 1.5. 0.5 milligrams once a week or once every like 10 to 14 days. And my T3 need dropped. So what I ended up seeing is even on a micro dose now, the T3 that I was taking. And the bottom line is T3 will burn fat and muscle. By the way, I talk about this when I talk about T2, that the forgotten thyroid hormone that is in Thyroid Fixer T2 protects your muscle. It only burns body fat. T3, like it or not, burns fat and muscle. It does not differentiate between the two. So the high dose that I was on now all of a sudden became too much. And I didn't experience anxiety or a hyper sensation. What I ended up experiencing was the need for less. The. The need for less. T3 I saw again a resurgence of muscle loss and hair loss. Now again, part one, go back and listen to the last episode. Part one is where I talk about using Manjaro in the 5 milligram pen when it first came out. And that's when I noticed the muscle loss that was all the way back in 2020. Now I'm talking 2025 and 2026. Microdosing. I noticed, yes, absolutely. I needed a change in my T3 dose because I was then all of a sudden over medicated. I was losing muscle again. If you're not overdosed, then you also have to be aware of the opposite happening. Conversion issues worsen or you feel more hypothyroid. Either way, if no one is monitoring you, you're flying blind here. So if your doctor put you on semaglutide, tirzepatide, if you're using ritatrutide and you never checked your thyroid, that's a problem. It's also a problem if you're not regularly rechecking it. Okay, so we talked about muscle. We talked about muscle in part one. Muscle is not just for aesthetics. It is a metabolic organ. It burns glucose, it determines your resting metabolic rate, it supports its insulin sensitivity. You lose muscle and your metabolism slows. Even if the scale goes down, your metabolism will downregulate. And many people on GLP1s are eating far less protein and they're just moving less because their appetite and energy are lower. I mean, you can get fatigue on day two having nothing to do like day two after your injection having nothing to do with your lower caloric intake and everything to do with just the drug itself. Don't ask me why. I don't know the mechanism of action there. So yes, you're going to lose weight, but not the right kind. If you are losing muscle. That's why A lot of these celebrities are looking skinny, fat, they're looking lighter, but they're looking weaker and they're looking older. Thyroid patients are already prone to muscle loss. Thyroid patients are already prone to muscle loss. If you have a thyroid, if you are a thyroid patient and you are over the age of 40, you are at increased risk of muscle loss. If you're not replacing your testosterone and your estradiol, if you're not on bioidentical hormone therapy and you're taking a GLP1. Oh, my God. What are you doing? You are going to lose muscle and you are going to age quickly. Oh, good. You're going to lose 10 to 20 pounds. Great. Your face looks like you're 80 and you have no ass left, no arms, no legs. You've lost your muscle. Now you have a lower metabolism. You can see I'm getting a little fired up here. This is the reality. This is the reality. If you want to put your head in the sand, we'll see you when you decide to pop your head up and you're almost dead because your body has withered away and you have no thyroid function and no metabolism, and you look like a stick figure. So we'll see you then. If you want to keep your head in the sand, that's cool. For my people that want to listen and maybe do something about it, keep going. Okay, so we're going to dive deeper into how this is affecting your thyroid. So we already know we talked about the hair loss in part one. Well, you're going to lose even more hair if your reverse C3 goes up. So remember, GLP1s often reduce the need for a higher dose of thyroid hormone. The good thing about GLPs is that they are decreasing inflammation. So that decrease of inflammation in the body can also mean that you need a lower dose of your thyroid hormone. But if you don't answer that call, if you don't reduce your dose, then you are going to lose muscle and lose facial fat. So the effects of the lowered inflammation are basically overridden by the fact that now you have a lower metabolism and less muscle and less hair, and you don't look so good. So, yes, there are some benefits to. Well, there are many, many benefits to GLPs when used the proper way. When used the proper way. But we need to be cognizant about how it is affecting our thyroid. Now, again, I am not anti glp. We prescribed them for our patients. I am taking it myself in a micro dose, but I'm taking it the right way. And I am very cognizant about my thyroid function. I'm very cognizant of my muscle and my hair. I listen and respond to any minor changes. If I even think I am losing a little bit of muscle, I stop the glp. I, I, I have gone months without taking a dose. Months now. Okay, I'm going to flip the tables on you and talk a little bit positive of how it can help the thyroid. We already talked about reducing inflammation when we reduce insulin resistance. That can improve reverse T3 as well, because we know insulin resistance is a driver of elevated reverse T3. So if we can reduce insulin resistance through the use of a GLP, we can actually bring down reverse T3. So in that scenario. Good. It's good. But the key is that you have to be strategic. You have to look to see exactly how the GLP is affecting you. You need adequate protein. You need to do the strength training. You need the micronutrient support. You need the thyroid monitoring. You need to be working with someone that knows what they're doing, who is checking your thyroid, dosing you properly. Hopefully, you're on the right thyroid medication to begin with, and you're not on T4. Only then you're working with someone who's going to monitor and work with you as you communicate with them. The different changes that you're seeing in your body, if you are noticing a loss of strength, if you're noticing hair changes, if you're noticing muscle changes. You know what happened to me? I looked at my arm and, you know, I work really hard. So if you're on YouTube, you get to see this. So actually, this is my bad arm. This is my, this is my smaller bicep. Let me, let me show you the other one. So I work really, really hard at my muscles. I really, really do. And see, I'm really proud of this bicep. I just am. So I got pretty decent, pretty decent arms, right? What I noticed when I start losing muscle now, I could go back to 20, 21. That was really bad. Like, I literally saw, like, skin hanging off. I went, oh, my gosh, I got my mom's arms. My poor mom, God rest her soul. Well, you know, when she was, like, in her late 70s, she didn't work out. I saw the loose skin and whatnot. Recently, if I go up too high in a dose, like I did last week or two weeks ago by accident, I will absolutely notice immediate changes in my muscle, like, immediate changes. So you have to be in tune with your body. Like, when I'M working out. I don't get the pump, I don't have the shape. So if you are noticing that, that is a huge, huge, huge red flag. Red flag. Make sure you monitor your thyroid regularly. Change up your dose of GLPs. Even if you are doing the strength training and the micronutrients and the protein and the blah, blah, blah. We, we all, we talk about that ad nauseam when we're talking about GLPs. But it is all about doing this the right way. They can help the right patient. But you have to be cognizant of what it's doing to your thyroid. You might need to change your thyroid dose entirely. You want to regularly monitor your reverse T3 because that can go up quickly when you are on a GLP1. So if you are on T4 of any kind, I don't care if you're on a natural desiccated thyroid medication that your naturopath gave you. If you are on any kind of T4 and NDT is 80% T4, any kind of T4, you look at that reverse T3. Now, I don't have to be as concerned with my reverse T3 because I'm on T3 only. So if you are on T4 of any kind, be cognizant of what your reverse T3 is doing. You might need a change in that T4 dose, meaning dropping the T4, adding in more T3. Or you might be like me on the other side who needed a reduction of their T3 dose due to the muscle loss. So this is what we are seeing with GLPs in the thyroid. Not necessarily 100% that. And yes, of course there is. I would be remiss if I didn't bring up the cancer, the thyroid cancer. If you do have a history of medullary thyroid cancer, there is a black box warning on GLP is that it's not for you. It is important to note that Those studies use GLPs like 20 times the amount that a human would. And humans versus rats. I said this in a previous podcast on GLPs. We have different receptors on our cells for GLPs than rats do. So it wasn't a great study, not a great comparison. Do not be overly concerned with the whole cancer aspect in your thyroid, but do be concerned and do be cognizant of how these GLPs are affecting your thyroid treatment, your thyroid quality health in general. We did see some studies show a reduction of free T3 when on a GLT1. So watch that free T3. Watch the reverse T3 and just pay attention to your symptoms. That's key. When we pay attention to our symptoms, when we tune into our bodies, that is going to give it us way more answers, way more answers than any lab. But you want to check your labs often as well. So key Takeaways we're going to test, not guess. We are going to check our thyroid function often. If we are on a glp, we already know that we're going to eat protein like it's our job and lift heavy. We know that. We know that already. We're going to be on bioidentical hormone replacement if we're over the age of 40. We are going to work with someone that knows what they're doing with GLPs that can actually help you with your caloric intake, with your protein intake, with your overall diet plan. For going on a glp, you're going to work with somebody that actually knows how to properly address your thyroid and optimize your thyroid and your hormones like we do at the Advanced Thyroid and Hormone Clinic so that you can stay optimized and reap the benefits of using a GLP. 1 the information shared on the Thyroid Fixer Podcast is intended solely for informational and educational purposes and it is not a substitute for professional medical advice, diagnosis or treatment. Always consult with your physician or other qualified healthcare provider with any questions you may have regarding a medical condition treatment or before making changes to your healthcare regimen, including medications, supplements, or other therapies. 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