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- [00:01]
Prime Obsession Host
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- [00:31]
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- [01:01]
Tessa Zali
Hello guys. Welcome back to the Treatment room podcast with your host Tessa Zali. So today we are diving into one of the most talked about ingredients in skincare right now everywhere pdrn. And today I am joined by Jan Marini herself. She is the founder of Jan Marini Skin Research. We are going to break down what PDRN actually does and how it impacts the the skin and what really separates high quality formulas from the hype. So Jan, welcome. We're excited to have you.
- [01:39]
Jan Marini
Oh my gosh, thank you, Tess. It's such so great to be here.
- [01:43]
Tessa Zali
You are such a beloved returning guest. Everyone loves our episodes. They're some of the most most downloaded episodes. So we're lucky to have you back. I want to ask you what, what is pdrn? What does it stand for and what is it doing for the sperm?
- [02:01]
Jan Marini
PDRN stands for polydioxide ribonucleotide. You don't have to remember that big word. Oh my gosh. It's, it's extracted from salmon sperm. So it's not salmon sperm. You know, you hear all these jokes on the Internet and, and social media. It's not salmon sperm. You could be allergic to salmon and you would not have a problem with this. This is something that is extracted from salmon sperm is through a very highly purified process. One of that it needs in order to really work the way that it works in the medical journals, it needs to have this very purified process and it's 98% compatible with human beings. Now we can't mate with animals, we can't mate with plants. So for the most part we're not compatible with another species. But there are a few exceptions. One exception would be pig valves because for decades historically pig valves have been used in heart surgery. We don't have to take anti rejection drugs. They work very, very well. And in this case this extract or these DNA fragments from salmon sperm were very compatible with. And there's lots of robust medical data. If you want me to get into that for a moment because this really validates it. Sure. Most people don't know. They think that somehow this just popped up and then some novelty thing that like for a while, remember you could go and get a pedicure and they put fish in there and they'd nibble away your. Okay, this is not a novelty. So historically, for a very long time, doctors by prescription have used PDRN either topically or by injection for people that have pressure wounds or diabetic ulcers. Now, particularly in individuals that are diabetics, we all have less blood supply to our extremities. But in diabetics, because they have vascular difficulties, particularly with insulin dependent diabetes, then there's a lot of issues healing on the lower extremities. And a diabetic could get a blister, they could get a little cut, not know it and it gets infected. It's very difficult oftentimes to address that. And if it turns into gangrene, they can't heal it. It results in amputation. So this is why you see more amputation with diabetics. Now what PDRN does, they inject that and it actually rebuilds tissue. This is a regenerative technology. Imagine that. You know, it's not about, oh, we're going to make some collagen, we're going to make some last, we're going to make it a little firmer. This is where they actually regenerate tissue. They avoid amputation. This is phenomenal. And so it began to be used aesthetically in Korea. Now that doesn't mean that Koreans are way advanced, way far ahead of us. They would inject it. It's not legal to inject in the face here in the US doesn't mean it won't be. Doesn't mean you might find some doctors that start doing it off label. But you know, to give you an example, I source ingredients from all over the world. I think I source one thing from Korea. So it's not like they're a hotbed of technology, although they do have a lot of devices that they use on the face and again, some of them aren't approved here. And I've seen some of the best skin in the world in Korea. I've seen some of the Best skin in the world in Japan or in Great Britain. But I've also seen some of the worst skin ever. And same thing with Korea. So they just happen to start using it for this and also topic topical use as well. And so most of the products that we've seen in the US because it's kind of flooded the US market, you can go on Amazon, are from Korea. I don't know. I know one product that's been made recently out of Canada. I don't know if, as far as I know, we're the first product literally in the world to be made in the US with the standards that would be necessary, in my opinion, for medical use. Also, I don't know about any company out there that's using any percentage anywhere near as high as what we're using. This is a different product and it has a lot of technology that also supports this. Now, when we talk about it being compatible with human skin, there's two aspects of this. One is penetration, and this penetrates. In fact, in medical articles, they say penetration is like putting water on sand and you know, how quickly water just absorbs into sand. But that's not why it works. It works because it has to connect with certain receptor sites on the surface of the skin. Now, we have all those receptor sites on every cell in our body, but the receptor site we're talking about is the A2A receptor site. It must connect with that, that's on the surface. When it connects with the HOA in turn, it then triggers something called adenosine, connects with that, and that's a little protein on top of our cells. And when it hits that adenosine, there's a cascading effect that happens that causes all of these incredible changes or regenerative benefits to occur. And let me just tell you, there's a. There's a lot. Yeah.
- [07:39]
Tessa Zali
Jan and I were just talking offline about everything she's seeing in the medical journals, all the cool discoveries. So, Jan, if you. Do you want to tell us some of the highlights?
- [07:52]
Jan Marini
So the skin rejuvenation is extraordinary. And I want to take a second to kind of define this by talking for a moment about the difference between rejuvenation and regeneration. Because 99% of what we use out there is rejuvenation. Nothing wrong with that. There are three technologies that fall under regeneration. One would be reboot. One is the right retinoid, and another one is our regeneration booster. Now, most of what you see out there, you might occasionally come across a retinoid that could Be the right retinoid, hitting the right receptor sites and everything. But these other technologies, really, other than if you're getting a really good pdrn, they don't exist. Or, excuse me, I shouldn't say that. Companies aren't making them. So here's the difference. So if Tess bought a house and she wants to rent it out, and the pain is peeling, the windows are all dirty, the grass is brown, it looks awful. So she repaints it, she cleans the windows, plants the grass, puts some flowers in. Now it looks charming. It looks appealing. That's regeneration. Rejuvenation is as she rebuilt the house. When you're using peptides, which are signaling molecules and using other things, it's wonderful. But that's not going to rebuild the house. This rebuilds the house. A retinoid, the right retinoid corrects instructions coming from your DNA, which is the basis of all aging. This works on the other end because it can actually synthesize new DNA through salvage pathways. And it just. Well, all I can say is it's extraordinary. And it's extraordinary for so many different things. And so to kind of go down that besides gist, the fine lines and the wrinkles and the texture and the brightness, it can stimulate collagen about 300%. Now, I don't know how to translate that into thickening of the dermis. Because with the right retinoid, 50 to 90%, thickening with glycolic acid, 33%, this is 300 times collagen. It's significant, but I can't necessarily translate it in a comparison. We also know that it causes the skin to heal tremendously fast. And this is important for regeneration because, for example, a peptide. One of the ways in which it kind of makes the skin look younger is it makes the skin think it's wounded. And the skin produces more collagen. So when you're dealing with inflammation and you're dealing with skin wounding, a wrinkle is a wound to the skin. How you're able to regenerate, that is important. On wounded skin, let's say you're having laser. What you're doing is you're decreasing the thickness of the skin. It increases that thickness because you want that to regenerate by 25% almost immediately. When I say immediately with the first day or two, for example, if you were to have, let's say, fraxel. And it takes on average about seven days for all of what we call scabs. Scabs could be honey crust or just that particulate and certainly with CO2 laser resurfacing, it'd be seven days or longer for that to fall off and the redness and the swelling to subside depending on the aggressiveness of laser. With PDRN it's 4 days reduction of 45% in healing. Wow.
- [11:39]
Tessa Zali
So incredible.
- [11:41]
Jan Marini
Every single person should be using this day and night. But also if you have a procedure, any of those kinds of things, it's going to have an extraordinary effect on the healing time. Now, acne PDRN triggers blood vessel growth. This is one of the reasons why it's really regenerative. And in doing that it transports certain factors that increase the density of the subcutaneous capillary network. And it does this by about 60%. Now that's huge because we'll get into rosacea also. Now what this does is this causes the discoloration of to fade more quickly. Now if you use duality, which is absolutely critical, it's going to be about 300% that it fades faster. But if you, and you do this, it's going to really also speed that up. And what happens is that you start to see more of a pinkness as that discoloration, the purplish or the brownish starts to recede. I look like I'm in a hole down here. But once that discoloration starts to fade, acne scarring then starts to decrease because it shows that there's collagen stimulation, there's roughly a 38% lessening in scarring. In the medical journals they even talk about patients that they don't feel they need to wear foundation. It also significantly decreases melanogenesis and that's brown discoloration. And I've seen this personally in terms of when I was doing a lot of my proof of concept and just over time anecdotally resellers that are using it, they're patients that are using it and it can make a significant difference. In one case, literally the person's, their facial color just changed. Even jawlines, they've done measurements on jawlines in which they saw a 32% decrease or increase in firmness. Again, skin texture amazing for a non surgical option. It just makes the skin look a lot younger and smoother. The skin also appears more volumized. Now this is really important test, think about this. The estimate, the statistical estimate, marketing estimate is that about 65% very soon of the population in the US will be on GLP1 weight loss drugs. Now what have we heard about that? We've heard that there can be a disproportionate facial fat loss. It doesn't happen in everyone. I haven't seen it in everyone. But in some individuals, we don't know if there's something genetic. We don't know some. They speculate that that person could have underlying structural issues that just really show up when they do something. That's a significant weight loss. But this is a volumizing product as well. So when we use retinoids, we use this, anything at all, booster that we can help to maintain volume and fat and collagen. That's really, really significant. Now, aging is considered to be an inflammatory disease, and there's other definitions of it as well, but there's a 60% decrease in inflammation. And that happens because PDRN literally starts cutting off the chemical signal for inflammation comes at it from a completely different angle. When people have erythema or redness, it decreases it by about 30, excuse me, 42%. And swelling, if you've got a procedure, whether it's IPL, whether it's Fraxel, it reduces that swelling 68% by day three. This is, I mean, these are also
- [15:57]
Tessa Zali
extraordinary because people hate downtime.
- [16:00]
Jan Marini
That's right. And so give you an example. And this again, this is. We've gotten back, by the way, we've gotten back our clinicals, a lot of our clinicals for microneedling practitioners out there. You can microneedle with the retail product.
- [16:18]
Tessa Zali
That's so great because there's a lot you can't use topically with microneedling.
- [16:22]
Jan Marini
You can't. We, we, we had this with outside physician clinicals. And, and also the, the results are really, again, very dramatic.
- [16:32]
Tessa Zali
And can I ask, is that because it's, it's not foreign to our body. That's why you can use it.
- [16:38]
Jan Marini
Topic is, I mean, you could just, you could just microneedle with just plain old pdrn, but you're not going to get the same result if you have these other factors that are helpful. I mean, they inject it. Yeah, 88% of physicians use it right along the filler. They believe the result is better. But also there's data that is indicating that it may work even better on its own because it's a bio stimulant, better than filler. So there's no reason. I mean, microneedling is not, it's not even going in, you know, it's not going in the bloodstream. You're just creating some channels. But it's the, the data we've gotten back is, is excellent. Now, rosacea. So in General with rosacea, it has to do with, with the kid and protein. It, it's not a disease of sensitivity, it's a disease of reactivity. Excuse me, a disease of reactivity. And it also is vasomotor instability. So somebody goes into a sauna, they turn bright red, they come back out and momentarily their skin comes right back down. But what happens in people with rosacea is those blood vessels are damaged, they're compromised and instead of expanding and contracting, expanding, contracting, they expand and they lose their flexibility. And this is what we see as redness and we see it as telangiectasia. And sometimes the redness is not permanent. It kind of comes and it kind of goes, but it can get worse over time. Well, PDRN doesn't act just as an anti inflammatory. It does. So we want to downregulate inflammatory pathways. Rosalie Skincare Management SYSTEM but with PDRN it actually works on the vessels themselves and it helps to bring back some of that basal motor flexibility. And as a result, overall the telangiectasius look very faded and the redness is much more decreased. It they've done studies with skiing structures like in the Swiss Alps. So you can imagine, you know, you could be wearing sunscreen and all that, but you're out there in the wind and that harsh weather and everything is just beating your skin all the time. And so it actually provides a protective film. And by film I don't mean it's something you can feel, it's just more that it is a protective. The, the, the, the beneficial ingredients are, or that or the PDRN itself is giving you a protective layer, so to speak, that prevents water loss and pre, and actually repairs that damage.
- [19:29]
Gloss Genius Promoter
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- [20:16]
Jan Marini
It.
- [20:16]
Gloss Genius Promoter
They also have all the HIPAA compliant tools you need for charting consents and client records without the chaos. You guys are always asking how I take client notes and how I keep things organized. I can't recommend Gloss Genius enough. And now you can see for yourself. Use code treatmentlossgenius.com for 50 off your first two months of the gold or platinum plans. Gloss Genius. More revenue for your business, more time for everything else.
- [20:45]
Jan Marini
As I go through a lot of the literature because this has been out there a while, again, using diabetes. And it's one of those things that's been a real sleeper as far as using it on the skin until recently. And we're just finding more and more all the time. At least I am.
- [21:03]
Tessa Zali
Mm. Do you recommend? Because I know you typically start with skincare management system and then add boosters later, but this seems so reparative. Would you recommend somebody could start it right away?
- [21:16]
Jan Marini
Absolutely. The reason why we wait on certain things that are additive adjunctive is because we need the skin to acclimate. So duality. We want the skin to acclimate first. Luminant. But this doesn't require any acclimation. In fact, it would probably help with acclimation. So. Absolutely. Oh, that's another study. Before we went on, you and I talked about this, but there was a study where they worked with influencers and influencers, because they're having to try so many products, there's a higher rate of reactivity and if you want to call it sensitivity or breakouts or whatever. And this using PDRN reduced it significantly.
- [22:02]
Tessa Zali
You know what? Every year, this time of year, springtime, I notice clients just have more bizarre reactions because inflammation is higher. So I'm really excited actually to have something to combat a lot of that,
- [22:16]
Jan Marini
too, is somebody could be reacting to pollen.
- [22:19]
Tessa Zali
Yeah.
- [22:20]
Jan Marini
Because you have pollen. And so that's not necessarily a topical issue. That would be. One of the things that really helps with that is using, like, a nasal spray, which would be Nasonex, which is now called generically mosaic. And it. What it does is it prevents you from reacting. Yes.
- [22:41]
Tessa Zali
Oh, I'm. I'm on all those things.
- [22:43]
Jan Marini
Yeah. So. And that's really helpful. But you're right, you know, you can get weird things. It's.
- [22:48]
Tessa Zali
Yeah, it's this weird connection I've seen, like, because I think the internal inflammation is higher, even the skin can be more reactive. So.
- [22:58]
Jan Marini
And I'm just saying. I'm. I think I came across. I'm just saying that there's anything else here that I maybe. Let's see if there's anything that I might have missed barrier function, which goes along with what they did in the Swiss Alps. But it really kind of, one of the ways in which they describe this is that one of the things that happens after laser and some of these procedures is the skin literally has to make bricks. It's like putting the skin back together again. It re epithelializes and PDRN actually alleviates the skin from having to make bricks right away. It makes it for it. Then the skin can take over and make its own bricks. And so that's one of the ways in which it has an effect so quickly after laser. And those kinds of things even burns. If somebody had a you. You could call a laser CO2 laser in which they, they talk about as a burn to the skin. Because with a CO2 laser that's ablative, that's literally taking off everything, as opposed to fraxel, which is behind little pinpoint fractions of skin that kind of reconnect more quickly. So a CO2 and so what it does is it closes that up incredibly, incredibly quickly. And we talked about how it can just reduce that healing time. And it just the fact of how it, it has this effect on blood vessels and that helps with rosacea, that helps with acne scarring. It's just, it's, it's just so many aspects of this. And that's why it comes under the heading of skin rejuvenation or, excuse me, regeneration. Oh, and by the way, besides collagen, it also stimulates a lot of elastin. It's a lot harder to stimulate elastin than it is collagen.
- [24:59]
Tessa Zali
It really seems like it's hitting on all the things that you would want in a skincare product. As an acne specialist, I really like the barrier component you're talking about because when somebody starts with me, Jan, usually their skin has been through a lot because they've been trying to treat their acne unsuccessfully. So, so they've tried so many topicals they might have not been taking care of their skin in the sun and, you know, just doing a lot of things to over dry their skin. So anything I can use to support the barrier so that we can then start the actives like benzoyl peroxide and duality is great.
- [25:44]
Jan Marini
Well, yeah, I totally agree with you. And one of the things also I can touch on kind of quickly that sheds a little bit more light maybe on sort of anti aging. So I've talked about this a lot before, probably incessantly, but the crux of everything that happens as aging has to do with instructions coming from our DNA. So our genes are made up of DNA and some of them are expressive. And that's the, the ones that spread out the instruction sheet. Now that's your body software. So if you had a computer and it didn't have any software, it'd just be a box, you wouldn't exist, you wouldn't function without the software. So that software corrupts over time. Because everything you do in your lifetime, from the time you're born, whatever you touch, whatever you eat, whatever you come in contact with, it could be in as innocuous as touching your desk. And now it's in your DNA. So that compromises those instructions. And when you get around 18 to 20, that compromised, those compromised instructions start showing up. And it's slow at first, but over time speeds up internally, externally, that's what receives aging. Now we talk about the right retinoid because we have alpha beta gamma receptor sites in our skin or retinoids. What they do medically, this is a fact, is they change gene expression or another way of putting that is they correct instructions. The instructions are more correct now when it. So those instructions are being sent out. And one of the definitions of aging is a loss of memory and information in every cell. So they're going to cells that have lost information and memory. Right now are those cells going, are everything going to improve? Yes. But think about this. If on the other end where those instructions are going, we can change that. Think about how much more profound it is. One of the things that PDRN does is it actually synthesizes new DNA through salvage pathways. The other part of this is that every person should be a law that you're not just using PDRN but you're using it with a retinoid because it's like being on steroids on say anti aging steroids.
- [28:07]
Tessa Zali
So it seems like you, I can tell you really believe in this. It seems like a lot more than just a trend. Right. You think this is a shift in skincare?
- [28:15]
Jan Marini
Absolutely. Because you're gonna. It's at medical conferences, particularly outside the U.S. and in the U.S. as well, but particularly outside the U.S. i mean it's the hottest topic, it's being discussed because it has so many regenerative, so much in terms of regenerative value. And the data as, as we're discussing the data becomes more compelling over time. It's so easy to use. Right. Just put it on your face and
- [28:50]
Tessa Zali
it's not an exfoliant. So I mean the tolerance is. Anyone can use this.
- [28:56]
Jan Marini
No you're, it's gonna, it's gonna make you more tolerant. It's just, you know, the feedback that we get is one thing to get excited when you're doing proof of concept and you're working with individuals, and then you also start doing outside clinicals. But when you, when you. It's in the marketplace and the feedback that you get, I mean, literally 100% about what people see and what they experience and how, you know, the difference that they notice with their skin. And of course, it excites me also, because I see a difference with my own skin. And one of the things that I really, really focus on in proof of concept, I like to have all kinds of different individuals in real time that I'm working with in proof of concept. But I also have a few people. My hair person is one who literally, I mean, Tessie uses everything, and I'm serious about that. It's gorgeous skin. So I like to take somebody where they say, oh, my God, my skin is the best it's ever been. I don't see I could get any better. Then you add this in, and if you see another big jump in benefits, that tells me a lot. And, and that's kind of the way it is with my own skin, because obviously I have access to everything. I'm consistent, I never skip. I do everything consistently. And so when I can add something in and see that there is actually even more of a benefit, and many times that's not the case, I'm not interested. If it's not going to be an additive benefit, I'm not interested.
- [30:34]
Tessa Zali
I know that to be true. You're very picky, and I know you wouldn't make anything, you wouldn't use yourself.
- [30:40]
Jan Marini
I've worked with exosomes. I've worked with everything. And the thing about pdrn, it doesn't need a blood supply. Exosomes, to really be exosomes, these little packets that are in your blood, little microscopic packets in your bloodstream, they have to have a blood supply. Now there's something called biometric exosomes. That means that what they've done is they have synthesized certain factors. They put them in, like a. Some kind of a nanotechnology or liposome technology, and they use that. And that's not to say that it's not delivering some good factors, growth factors. Oftentimes they get this from umbilical cord or things like that. But it's not truly an exome, because exosomes can't survive in manufacturing. It's kind of like Using a. A good example is like tns, which has been around for years. Not a bad product at all. I wouldn't call it a regenerative technology, but it would be more like that. You're still getting some really good factors.
- [31:40]
Tessa Zali
There's kind of a moment right around growth factors and exosomes. How would you say PDRN is different?
- [31:48]
Jan Marini
Well, those types of things aren't regenerative. So regenerative again would be literally rebuilding the house. So we could take, we could rub exosomes on a wound and it wouldn't keep it from necessarily turning into gangrene or being amputated. It's not actually regenerating tissue.
- [32:07]
Tessa Zali
There's a true medical regeneration happening.
- [32:10]
Jan Marini
Oh my gosh. Yes. This is, this is where it kind of, sometimes it gets minimized because people don't understand that the really medical history of this and how profound this is.
- [32:24]
Tessa Zali
How can consumers differentiate between, you know, a twenty dollar formula?
- [32:30]
Jan Marini
And I can just tell you, I know how much it takes to make this product.
- [32:34]
Tessa Zali
Yeah, tell us how much does it cost?
- [32:36]
Jan Marini
You have no idea. I'm not going to go into a lot of proprietary information, but just let me tell you. Recently, one of the types of salmon that's been used and you don't have to have a certain type of salmon, it should be cold water, it should be like wild salmon. But Japanese chum was discontinued because all of a sudden worldwide it became an endangered species. And a lot of it was being coming from Japanese chum and the other types of salmon because of the purification processes goes through. Now you could buy some real cheap knockoff, but if you're going to have it really purified the way it needs to be, the cost went up by 40 times. Now we're doing it in such quantity, we've been able to get that down to some extent. But let me tell you, it is horrendous. You have no idea how expensive this technology is to get it in the percentage we're using. And when I was doing a lot, this has been a two year process when I was doing a lot of research and again there's products on Amazon, some of them would say they were pdrn. They didn't even list it in the ingredient listing.
- [33:49]
Tessa Zali
That's the crazy thing about skin care. They can put anything on a label,
- [33:53]
Jan Marini
all coming from Korea. So I know of one product that has come from Korea and it has been used in the US and there's a couple of Medispas that actually carry it, but the percentage is nowhere near as high as ours.
- [34:09]
Tessa Zali
What kind of percentage should somebody look for?
- [34:14]
Jan Marini
They're not going to list the percentage. It's not legal, ah, illegal for us to really talk about percentage. You know, I've done it in acne and things like that because that's different. That's considered an over the counter drug. But when it's not a drug, percentage indicates that it is a drug.
- [34:26]
Tessa Zali
Would you see something higher up on an ingredient label if it was more legitimate?
- [34:32]
Jan Marini
You know, probably. But the thing is, is that when you're getting products from outside the U.S. and they're coming across into the U.S. do you have somebody standing there that is an expert and looking at the ingredient listing and say, oh, you've listed this according to exactly how you're supposed to. From the biggest to the smallest. It can be all over the map. They don't necessarily have the same oversight that we have the same rules. And so, and this is, and being a product researcher for well over 40 years, you know, I see this. It's, it's, it's rampant. And even if there are certain laws or oversight that a country has, they can get away with a lot just by exporting something. Because again, unless the FDA comes out and says, oh, this has got arsenic in it or this has, you know, mercury or something like that, where it is absolutely going to be an FDA oversight. The FDA doesn't even regulate cosmetics. And so when I talk about something that's appropriate for the medical market, it also has to do with where it's manufactured. So we manufacture in a gmp, which stands for Good Manufacturing Pro, Good Manufacturing Processes. But that is the designation for a drug lab. So it's the same lab in the same oversight. We're making cancer drugs, antibiotics, anything like that. Very few products are manufactured in that type of a lab because it's very expensive and it can take years to get approved and it's inspected by the fda. Let me tell you, they're brutal. So GMP lab, for example, in a GMP lab they have things that are called clean rooms. And one time I gave a doctor a tour of our GMP lab and she was looking at the clean room. She says, oh my God, I could do surgery in here. I mean, it is so highly structured and it's required by law that they get inspected on a regular basis and cosmetic labs don't. Now if there's a complaint or they're making sunscreen, which is an over the counter drug because they're not allowed to make sunscreen. And that's another thing. The Ones that are really well known in the marketplace, but they could be made in a cosmetic lab as opposed to a GMP lab and, or let's say benzoyl peroxide, which is an over the counter drug or other things that are not allowed to be made because they're not getting inspected. So you, the consumer, you know, these are things that you really need to know about these products. Because just because a product is expensive doesn't mean it's being made properly.
- [37:20]
Tessa Zali
I think that gives us a lot of insight into PDRN that we didn't have before. Is there anything else that you wanted to touch on?
- [37:30]
Jan Marini
I say this a lot, but I'm going to emphasize it and that is I always tell people, you don't need another product. I don't need another product. You need a solution. Really don't put anything on your skin unless you know it's going to really address a concern that you have. Maybe you have acne or discoloration or you'd like to have fewer fine lines and wrinkles or your rosacea or any of those kinds of common skin concerns. Because there really are technologies that can make a huge difference and think about how you look and feel about your skin. You looked in the mirror and didn't have those concerns.
- [38:09]
Tessa Zali
Yes. And I think the issue is there's so many products, there's so much over promising but very few brands putting the research into these products the way that Jan Marini does. Oh, thank you very much.
- [38:23]
Jan Marini
Well, this is, this is my passion. And you know, that's another thing, really, you should contact Tess because she is a genius when it comes to a lot of these skin concerns especially. I know that you like to specialize in acne and we've used some of her before and after pictures because they're really, really are just tremendous and it's, and, and so inspiring.
- [38:54]
Tessa Zali
It's so awesome to find a line that you can rely on and trust as much as yours. Because my process with my acne clients is, is just really seamless in getting people clear. Now I, I'm not wondering, you know, if it's going to happen. It's just a matter of time. So, so it's great to have the expertise and the knowledge, but then have the, the treatments that I can rely on to make the process as easy as possible.
- [39:23]
Jan Marini
I'm starting to recommend it for acne patients just because it has that tremendous effect on the anti. Acne is an inflammatory disorder. It has tremendous effect on that and also the scarring and it just adjunctively I think it's really helpful. So, yes.
- [39:39]
Tessa Zali
Oh, my clients are going to be so excited about it because that's almost the thing that bothers them more than the acne sometimes.
- [39:47]
Jan Marini
So I think that once you get the acne cleared up, but somebody looks at you from a distance and they think you still have it because you have the discoloration. Now the good news is it's not a scar because it's not an injury to the dermis. Scars injury to the dermis. But it is still something that can take a long time to go away. And with. We haven't had enough experience in terms of anecdotally with pdrn, but the medical data shows that it really can make that discoloration go away faster. And as time goes on, I'm going to be really interested in seeing how that translates into the real world and individuals and how the scarring and all of that resolves.
- [40:33]
Tessa Zali
Well, it's amazing that it can target both red and brown, right?
- [40:38]
Jan Marini
Well, it targets the brown by increasing that circulation, which then causes or the vascularity which then causes the brown to decrease. So it doesn't actually go after the brown is not brown like this coloration the sun. It really has to do. It's actually vascular because what happens is that you create the inflammation, creates little, I guess you could say, discrepancies in that microvascular system. They get leaky and they leak out the color of blood. And that's one of the reasons why it kind of in a sense stains the acne scar. It goes about resolving it in a different way. When we say that we can get rid of it about 300 times faster. For example, with duality, it has to do with things that remove the bilirubin and Verity Rubin, whereas PDRN comes at it from the angle of vascularity.
- [41:38]
Tessa Zali
Well, I'm excited because I have a lot of that as a rosacea girly.
- [41:45]
Jan Marini
Yeah. So it'd be interesting to see.
- [41:47]
Tessa Zali
Yes. Especially in combination with duality and Rosalie and all of your other amazing treatments. Jan, thank you so, so much for your time and your expertise. This is amazing.
- [42:00]
Jan Marini
Oh my gosh. I. This, this is so enjoyable and I always love our conversations and thank you everyone.
- [42:07]
Tessa Zali
Thank you guys for listening. So we hope you enjoyed this episode. Please feel free to let us know if you have any follow up questions. You can DM me on Instagram at my sdtessa. And thank you again, Jan for joining. We will talk to you all in the next episode.