The treatment of asymptomatic aortic stenosis, the move to composite endpoints in trials, IFR vs FFR and high-frequency low tidal volume ventilation for AF ablation are the topics John Mandrola, MD, discusses in today's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Aortic valve intervention for Asymptomatic AS

Lindman editorial https://jamanetwork.com/journals/jamacardiology/fullarticle/2829881
Trends https://pmc.ncbi.nlm.nih.gov/articles/PMC11308430/
Podcast EARLY TAVR Nov 8, 2024 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1001865
Faith Healing and Subtraction Anxiety https://www.ahajournals.org/doi/10.1161/circoutcomes.118.004665
Early TAVR trial https://www.nejm.org/doi/10.1056/NEJMoa2405880
EVOLVED https://jamanetwork.com/journals/jama/fullarticle/2825540
AVATAR https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057639

II Trial Endpoints

Shepshelovich https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2830023
Brown meta-analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785560

III IFR vs FFR—a debate b/w RCTs and observational data

5-year DEFINE https://jamanetwork.com/journals/jamacardiology/fullarticle/2824470
5-year SwedeHeart IFR https://doi.org/10.1016/j.jacc.2021.12.030
Eftekhari meta-analysis https://doi.org/10.1093/eurheartj/ehad582
Gotberg SWEDEHEART Registry https://doi.org/10.1016/j.jcin.2024.12.003
Editorial of SWEDEHEART-Registry https://doi.org/10.1016/j.jcin.2024.12.014

IV High-frequency low-tidal-volume ventilation for AF ablation

Osorio et al https://doi.org/10.1016/j.hrthm.2024.07.094

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Feb 28 2025 This Week in Cardiology