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Welcome to the Thriving With Addiction podcast, where we explore how recovery is not just about surviving, but about truly living. Each week, we'll dive into the science stories and strategies that help people and families heal from addiction and build healthier, more resilient lives. I'm your host, Dr. John Avery. Let's get started. I'm John Avery, and welcome back to Thriving with Addiction. Today we're joined by Dr. Albert Garcia Romeo Al is an associate professor of psychiatry and Behavioral sciences at the Johns Hopkins School of Medicine, where he is also the associate director of the center for Psychedelic and Consciousness Research. This research examines the effects of psychedelics in humans, with a focus on psilocybin as an aid in the treatment of addiction. He earned his doctorate in Psychology in 2012 from Sofia University, where he studied self transcendence, spiritual experiences, and their relationship to mental health. Al, welcome.
B
Hey, thanks.
A
No, really lucky to have you here. And your bio sort of speaks a little bit to maybe how you got into this field of studying psychedelics with your interest in spirituality. But walk me through how you ended up in this interesting space.
B
I mean, it was really kind of a long and winding road, I suppose, that brought me to all this. And it was certainly not a planned excursion, but I had a lot of interest when I was studying psychology in undergraduate, which was a long time ago at Tulane University. I thought abnormal psychology and the pathology and diagnosis and the work we were doing, even some of the more biologically focused work like cognitive neuroscience, was very interesting. But then when I was also doing more humanities related work, philosophy of mind, consciousness studies, and also studying different world religions, particularly some of the contemplative traditions, Eastern religions like Buddhism, Taoism, Hinduism, and lots of meditation types of practices that were involved. There had already been some cross talk between those, but they seem very disparate when we're talking about mind and consciousness, if you will, from the sort of Western psychological and neuroscientific standpoint and what all these other traditions were talking about in, you know, contemplative practice and meditation. And so that really just got me thinking about, you know, what the nature of mind and consciousness were and how these things could be conceptualized in different ways. And that also kind of opened up an interest in altered states of consciousness. And that was specifically kind of opened up by doing some meditation practice myself, you know, when I was an undergraduate. And that was something that got me interested in the area as well from a firsthand standpoint. So that kind of opened the door to some of what I ended up doing. But there Are a lot of other things that I think contributed to that. Spending a good amount of time outdoors in nature, that kind of opened up certain types of transcendent types of experiences I would have when I was out there. That was a big piece of it for me. And also at the time, I had been reading a lot of Maslow and reading about peak experiences and how he kind of conceived them in terms of their relationship to self actualization. That kind of brought all these different pieces together such that I became interested in what it meant for people to have experiences that they felt were transcendent or beyond their normal sense of self, and what types of mental health impacts those experiences could have. And I knew that during meditation, people could experience things like that. In nature, people could experience things like that. And of course, you know, with psychedelic substances, people can have those types of experiences. And, you know, they're not always all positive. They can lead some people into psychotic reactions or, you know, delusional thinking or lots of other issues. But there are also, you know, documented cases and instances in which people report these experiences can be quite pivotal in terms of their thinking and sometimes making positive changes for their physical and mental health. And that kind of goes hand in hand with some of these ideas around, for instance, recovery from addiction, where, you know, people can have these very, sometimes these very profound experiences, what they might consider spiritual or at least very meaningful to them, which can often lead to some behavioral changes or changes in the way that they relate to a particular substance or the, you know, substance use in general. So kind of a long convoluted path with, you know, a lot of different pieces that came together. But I was fortunate because I went to a sort of outside of the mainstream graduate program, which was then called the Institute of Transpersonal Psychology. And so that was a place where we could really ask these types of questions. And everyone who was there was, you know, required to do body based practice like yoga or aikido, as well as doing other types of, you know, kind of more didactic coursework around psychology. And so it really lent itself to doing these types of inquiry around experiences that were kind of outside the norm of everyday experience and, you know, what those might mean and how we could use them in therapy.
A
Was there some personal experiences that led you to explore this route as well?
B
Absolutely. I would say, you know, a couple of them that really stuck out was in one of my. It was, I think, called matter and consciousness or something like that. And one of my philosophy classes, the graduate student who was kind of the ta, started a Meditation club at Tulane that year. And so I started going to the meditation club, which was in our chapel, which is a very pretty building there. And we would practice various different forms of meditation. And I thought, you know, starting with certain types of, like, anapana, mindfulness of the breath, things like that. You know, they were compelling and interesting, but I really kind of got blown out of the water when I was first exposed to and first sat and did what they call a meta loving kindness meditation practice, which I'd never read about or didn't have any real experience with. But when we sat there and actually did it, I had very much of this sort of timeless, spaceless type of experience, was very much filled with emotion, positive emotion. You know, found myself crying even, and was not expecting that, you know, to do that, you know, on a Tuesday evening, just sort of sitting with a group of students and, you know, in this chapel. And so that was one, you know, one of those experiences that kind of hit, you know, home to me that this could be an important thing to look at and certainly that it could be healing or therapeutic in its own right.
A
I studied philosophy and religion in college and then, you know, went on to study addiction and be an addiction psychiatrist. And throughout my journey, my friends, family, and even a lot of my mentors were like, what are you doing? This is not, you know, this is not the path to take. And, you know, there's a lot of stigma towards studying these experiences. Did you encounter that? It sounds like you were very lucky at Sofia University, but. But there must have been some. Well, how did people respond to you as you explored all this?
B
Well, you know, I think my. Thankfully, my family and my teachers were supportive. I mean, I had a lot of support along the way. I also had my own, like, mental health struggles, a lot of depression and some substance use issues myself. And, you know, a lot of people around me. It was kind of, you know, one of the things that I ended up doing. And I guess this is kind of part and parcel to the, you know, work that I'm doing now was, you know, after undergraduate, I didn't really know what I wanted to do. And so I was working in odd jobs, including in, you know, bartending and working in service industry. And, you know, being around that in. In Miami, certainly there's a lot of, you know, alcohol and drug use. And seeing that also kind of just reignited my interest in how certain people seem to have no problems with that. And they kind of got on with their lives. And other people was very clear that they kind of would get into these really deleterious cycles and that they would not necessarily be able to get themselves out of that. And also noticing, you know, that I also had a predilection to that and I could potentially see myself getting caught in these cycles if I didn't do something about really kind of spurred me to move on to going to graduate school. And so I think that, you know, although it was a non traditional career path, again it, I had a lot of support from my family and I had a lot of really good mentors, like the whole way through, including once I arrived at graduate school where, you know, I was working with people who had been, you know, studying altered states of consciousness and you know, studying psychedelics in the 1960s, like Jim Fadiman, Charles Tartt. So these were people that had actually brought a fair amount of academic credibility to this type of work and they took me under their wing and were very supportive there as well. So I, I got lucky, I guess, to be able to do this. But yes, I was kind of coloring outside the lines in a lot of ways. Like you said, it wasn't a clear cut path forward and, and I, you know, I didn really know where I was headed. I was mostly just following what seemed interesting to me.
A
But it sounds like it was also sort of healing for you that process. And that was my experience too, that that going through it, you learned a lot about yourself and why you struggled, why family struggled. And it makes the work we do even more meaningful.
B
Yeah, that's right. And you know, I think as any good program for, for instance psychologists, you know, would I require that you go through a good amount of psychotherapy yourself just to sort of learn the ropes from both sides of this, of the couch and being, you know, in that, going through that process and you know, working with a cohort of other therapists in training, many who are now, you know, still really close friends of mine and also great therapists in their own right and you know, doing lots of reporting work out there. It was a journey, you know, and it wasn't just a journey about learning, you know, reading books and you know, accumulating knowledge, but it was also about self reflection and understanding, you know, oneself and you know, how, how you sort of end up with certain types of patterns or, or problems and you know, how do you use that information to help other people as well?
A
Well, I'm glad you tackled all this and help us understand your main area of research, these psychedelics. What are psychedelics to start for those that sort of have a Vague idea from the media or from movies. What are we talking about with psychedelics?
B
Well, believe it or not, psychedelics is still kind of a fraught term in terms of what exactly is a psychedelic. I like to go back to the sort of historical source, which is specifically, you know, British psychiatrist by the name of Humphrey Osmond. And this was in 1956 and 1957, when he was already doing very early work with LSD and mescaline. And he was out in Saskatchewan in Canada, and he had been investigating these drugs. He thought that it would be possible that he could get people who were in the throes of alcoholism specifically to have a sort of simulated rock bottom experience by giving them like a high dose of LSD or mescaline and by kind of having this terrible experience with this drug that maybe it could kind of help them come around and make some behavioral changes. So this was sort of some of the working hypothesis that he had at the time. And again, this is, you know, quite early on in the field. But what he found instead was that actually these people were often coming back and reporting these really insightful experiences and very meaningful experiences and sometimes experiences that they describe as feelings of interconnectedness and, you know, revealing sort of new thoughts and insights about themselves. And so this sort of forced him to reckon with the fact that these drugs, at least at that time, were really most often referred to as psychotomimetics. You know, so there are hallucinogens or psychotomimetics. They were drugs that would cause people to hallucinate or have psychosis. At least that's what people thought at that time. And Osmond said, no, you know, people are finding new parts of themselves and they're having sort of new insights when they're under the influence of these substances. And so that causing the sort of suggest the term psychedelic, meaning it would help reveal what was in the psyche or uncover what was already there in the mind. And so that was the word that he proposed in 1957 specifically to talk about these drugs, LSD, mescaline. Around that time, psilocybin was first sort of documented in the scientific literature in the west as well. And so this would also account among those what we call now classic psychedelics. And these are substances that they definitely function on the serotonin system. This specific activity at serotonin 2a receptor seems to be particularly important. But there's also a whole lot of other drugs in that have sort of gotten thrown under this bigger umbrella of psychedelics. And so you've likely heard of others like mdma, which is often also referred to as ecstasy or molly drugs like ibogaine, you know, ketamine. So lots of other drugs that from a pharmacological standpoint work a little bit differently, have also sort of fallen in with this whole class of what people call sort of loosely psychedelics. But often, you know, the ward can be really meant to talk about a class of experience that people can have as well. And that really relates to this sense of altered perception, altered sense of time and altered sense of self. And so that's really why all these drugs are often lumped together, because many of them can induce similar types of experiences that people would have where their sense of time, their sense of self, their thinking and their emotions are deeply shifted temporarily. And during that time, there appears to be a window in which it allows them to step outside of some of their normal patterns and potentially reevaluate those and possibly even make some changes in those patterns. And so that's really what we've been studying. And so it's those substances like psilocybin, lsd, you know, mescaline, as well as, you know, the experiences that they induce that, you know, we kind of study in this field of psychedelic medicine. Right?
A
And before we talk about sort of the benefits and risks in the clinical setting and targeting specific conditions, what, what are the benefits and risks for people to just experiment casually out in the world and maybe even talk a little bit of how that might differ from how they're used in clinical settings.
B
So people have used psychedelic substances, especially these naturally occurring psychedelics, for it seems to be thousands of years. We have archeological records showing people have been using psilocybin containing mushrooms. So they're found in all these mushrooms that grow all over the world. But also mescaline, which is derived from different types of cacti like peyote or San Pedro. Dimethyltryptamine or dmt, which is a close cousin to psilocybin, is also found in a number of different plants and animals and has been used in admixtures like ayahuasca in indigenous cultures. So for a long time, people abuse these. And in terms of what the kind of risks and benefits were in those settings, they're not particularly well documented. You know, from a scientific standpoint, there was a really interesting project that was done back in the 90s, kind of going down to look at indigenous practitioners who and people who would use these substances regularly as part of their religious life. And really what they found was just that there didn't seem to be any negative empathy. In fact, if anything, they appeared to be as healthy or healthier than people around, you know, the same areas. And this was, I believe, done in Central or South America, showing that, you know, those folks seem to be operating at a good or better level than people who didn't use Ayahuasca. But, you know, from a sort of more recreational standpoint, people have certainly used these drugs for a very long time. And really, a lot of that kicked off in the US and, you know, in the West, I would say, in the 1960s when, you know, bands like the Beatles and Pink Floyd and the Doors were coming into popularity and, you know, they were using these drugs and, you know, it really became kind of swept up in the countercultural movement. You know, nowadays there's sort of a whole new zeitgeist and seeing around these and, you know, their use. But the studies that we've done at least, you know, on a relatively small scale, we're talking in, you know, maybe in the hundreds, but also epidemiological data, which, you know, often is coming from tens of thousands or more people, seem to indicate that for some people who are using these out there in the world, there can be mental health benefits, including things like reduced risk of addictions to things like tobacco or opioids, potentially reduced risk of suicidal ideation. You know, there was just a paper published in the clinical setting related to that, but I'll save that for later. And, you know, even in the sort of smaller scale, prospective longitudinal studies that we've done, which have been in, you know, hundreds of people, when we sort of follow their trajectory and measure before they use any psychedelics, like, in this case, psilocybin. And then afterwards, the majority of these people, on average, are showing what you think of as salutary effects, like reductions in depressed mood, reductions in anxiety, improvements in cognitive flexibility, improvements in emotional regulation. So these seem to be the types of benefits that some people can experience when they're using these substances outside of a more clinically oriented setting. But there are a lot of caveats that are not always captured when you're looking at the averages or the aggregate data, because there are often some, at least in one of the big studies that I publish, I think it was in the ballpark of about 9, 10, 11% of people who ended up having some pretty serious problems, you know, mood issues, you know, other types of relational issues that they feel like they stem from their experiences using psilocybin recreationally. So there's always some subset of people for whom these experiences can not only not be beneficial, but could potentially be harmful. And so that's also something that's really both interesting for us to study and try to understand more, but also so that from a clinical standpoint, we understand who are not good candidates to receive these types of treatments should they become available.
A
So it sounds like potential benefits and maybe lower risk even than some other substances that a lot of people use. But some of the risks are for people with mental health issues. And then what about the risk for addiction, Frank? Addiction to. To these. Yeah.
B
Well, I mean, I'll turn the question to you, right? You're an addiction psychiatrist and you see patients with. With substance use disorders, I imagine. Yeah. So, like, how often do you would you say you've seen in your career people who come in and say, you know, I'm addicted to this lsd, I need to get off of it, or I'm addicted to the psilocybin, these psilocybin mushrooms, and I can't stop using them.
A
I'd say it's pretty rare, and I think the numbers show something similar. What I tend to see more in my addiction psychiatry practice is people that have some mental health struggles, psychosis or bipolar, that seems to have been made worse by their use, I'd say. And then I get a lot of questions from family members saying, my teenager has started experimenting, or everyone in the PTA is using chocolate bars that have a little bit of hallucinogens in them. I mean, what do you say to those groups too?
B
You know, I would say that buyer beware. Because, you know, there have been studies that published showing that what's out there, if you're buying these chocolates, like in places where they may be available on a counter, is not always what is purported to be in there. That includes sometimes there are research chemicals that we don't have good knowledge about their safety and toxicity as well as the dose, you know, may be quite different than what. What's expected. Um, and the other issue, I would say, is that both around the risks, they are real and they're, you know, real risks to people, as you noted, you know, who may have a predisposition, either latent, which they're not even aware of, or, you know, one that they. They may have had some experiences with things like manic episodes, psychotic episodes, or even prodromal types of features of those which can be triggered or exacerbated by some of these drugs. And it doesn't necessarily have to be a large high amount. Using these high doses, it's possible that Repeated low dose administration could lead to that. And actually, one of my colleagues here, I think it was Dr. Paul Kim, who published a nice case series about this not long ago where, you know, people ended up having the types of problems that you noted around psychotic illness or bipolar mood that seem to have been kicked off by, or at least, you know, exacerbated by some psychedelic use, including microdosing. The other big thing that I say about microdosing, which I think is important to highlight and emphasize, is that there has not been a controlled clinical trial showing that it has any significant benefit in terms of mental health. And so there have been studies, for instance, using microdoses of LSD in people with adhd. There's been other studies of psilocybin, mushrooms, microdosing in people with depression. And these are not shown to be any better than placebo in those types of studies. There haven't been a ton of them. And, you know, it's quite difficult still to do these types of research studies. It's expensive and, and so on. But, you know, the studies that have been done with the, you know, randomization and placebo control and rigorous sort of design in place have not shown that it actually is helpful. So, you know, because of all of those things, I tend to err on the side of, you know, being cautious around, you know, people using these substances kind of casually in those ways, and particularly because, you know, there's also obviously legal ramifications.
A
What about in the clinical setting now, even though, yeah, some concerns about use out in the community, there's a ton of excitement in this in the clinical space. Tell me what you found and what we should know in terms of both mental health and addiction.
B
Yeah, well, there has been a lot of work that has been focusing, and this has been, you know, now decades in the making of research focusing on the use of drugs like psilocybin, mdma, lsd, you know, within sort of a structured setting to help people that are dealing with a number of different mental health conditions. And that would include things like major depression, generalized anxiety and substance use disorders. You know, those, I would say, have been some of the biggest areas of interest where you've seen a lot of evidence accumulating, you know, oftentimes slowly and little by little. But we're kind of getting to this breaking point where it appears that we may see some of these drugs actually approved as new medicines within a relatively short amount of time, meaning, you know, they may become available for doctors like you'd prescribe to patients and to administer in A therapeutic manner. And so I think that's going to be both very interesting and very exciting because it represents potential sea change in terms of how we're able to treat certain conditions and some of which have been very recalcitrant to treatment. And I think addictions and mood disorders are two of the big areas that are, you know, of most interest at the moment. So, yeah, stay tuned because I don't really know how things are going to unfold over the next few months or years, but having kind of kept my finger on the pulse now for some time, you know, I, I would say there's quite a bit of excitement, even more so than I've seen, you know, since I started in the field, which is like 14 or so years ago. So.
A
And how are these substances given in the clinical setting? What, what if a patient comes into one of the research studies? What, what?
B
Well, we have a whole process that we go through and you know, we would hope that should these become FDA approved, that there will be a similar type of, you know, wraparound care that's in place. But there's normally a sort of screening for eligibility where we would look for those things that might rule you out in terms of safety. If you have a cardiovascular problems, if you have a history of psychosis or bipolar mood, or you have the family history of some of these issues, that can often be a red flag that perhaps this is not a good candidate to get a high dose psychedelic treatment. Once we kind of get through that and we find that this person seems to be safe, we would do a course of preparation where that's usually several weeks of counseling without any sort of drug on board, but mostly just talking about what to expect and forming treatment goals and, you know, getting a good sense of the patient's sort of life history and their symptom burden and, you know, what they would like to work on and get relief from. And that would move into the drug dosing where there's typically anywhere from one to three high doses administered of a drug like psilocybin or LSD or mdma. And those, those administrations are usually spaced out by several weeks from one another. And you know, during those drug dosing sessions, people are usually kind of lying down on a couch. They're not really being talked to very much. So we, we wouldn't be doing any sort of therapeutic intervention during the drug experience, but really asking people to have an introspective experience where they may lay down for six hours and listen to music and sort of just reflect on what they're feeling and what's going through their minds. And you know, once that's over and people are typically releasing the care of like a friend or family member, then there's this period of aftercare, often referred to as integration. But really it's a period where people are coming back and talking about what, if anything, kind of came up for them during these experiences. I know there's a sort of misperception that people will often have these mind blowing experiences that are incredibly insightful. But there's a lot of different, there's a lot of variances how people respond to these substances and how sensitive they are to the doses that we administer. And so that needs to sometimes be calibrated somewhat. Dose may need to go up more or not. But regardless, the next several weeks in aftercare is a period of sort of reflection, meaning making and continued support towards those therapeutic goals that had been set forth in the preparation period. And so even if a person feels like they didn't have an experience that was incredibly productive, you know, the therapist is still there to help them make meaning of what they're going through and also to support any sort of progress that they are interested in making. And if that's, you know, around substance use or around mood, you know, trying to find ways to capitalize on the therapy during that window. And you know, that's the kind of general model that we use with this high dose psychedelic therapy. But it has shown now, you know, in a number of different studies to have this significant antidepressant effect, significant anxiolytic effect, and also to really help people who are struggling with things like alcohol, tobacco and cocaine in terms of, you know, increasing their, both their abstinence or their likelihood of becoming abstinent or reductions in their, in their regular use. So that's really what the clinical evidence to date has suggested. And the reason why I think there is so much excitement and why this is sort of under consideration right now, seriously, is a potential new treatment paradigm.
A
Right. And the data is pretty strong. Right. Especially for mental health, maybe ptsd, mood and then for alcohol and some other substances that it really improves outcomes.
B
Yeah, I mean, there are now, you know, a number of these randomized control trials. There are still problems and I think, you know, it's good to be aware of those. It's almost impossible to really do a placebo controlled study with these because, you know, if you're laying on a couch for an hour and you took a pill, you will know if you have a feeling of these subjective drug effects which tend to be very profound with the high doses that we use, or if you're just feeling nothing, in which case often that can lead to what we call a nocebo effect, meaning not only are they, you know, not getting a response, but they're so disappointed they didn't get this treatment that they want. They, you know, they were interested in trying that their depression or their anxiety may even, you know, become worse to some degree. And so it's, it's really hard at this point to parse out, you know, all of the clinical impact of these drugs because of these methodological difficulties. But, you know, regardless, the data that has been accumulating really does kind of point to this signal of efficacy and, you know, shows relatively good safety, you know, in these well controlled contexts. And so with that, you know, you are seeing, you know, These now phase 3 clinical trials emerging with hundreds of patients where you do see this, you know, statistically significant and, you know, in many cases, clinically significant signals that, you know, somebody who receives a single dose of psilocybin, for instance, with a few weeks of talk therapy may be six or more times more likely to quit smoking, for instance, than someone who received an FDA approved treatment like nicotine patches with counseling. And so when you look at those data, I think it's a very, makes a very compelling case for considering, you know, whether these should be available to people. And particularly given that when given in these types of settings, we have a very good safety record.
A
Right. And in terms of what makes it effective. And it may be hard to tease this out, but how much is sort of the experience that one has versus what it's doing to the brain or not?
B
Yeah, and yeah, that's a great question and is one that we don't know the answer to. It would be nice if we can say, well, it's 40% the experience and 60% that it's inducing some neuroplasticity in the prefrontal cortex or something. But the real problem is we at least to date have not been able to sort of separate out the two, because when people get the drug, whatever it's doing in their brain is often inducing these types of experiences. We can use other drugs like benzodiazepines or anesthesia, which people have used to try to basically make people unconscious of the effect. The problem with that is you have now complicated polypharmacology going on where the combination of the drugs may be doing something to sort of render the key ingredients or the signaling cascades that may be happening ineffective. And so it's hard to tell even from those types of very sophisticated experiments where the magic is happening or, you know, what is the therapeutic mechanism at play. One of, you know, some of the data that we have definitely point to an importance for the relationship between the person who is overseeing the treatment, whether their therapist or facilitator, and the. The person who's going through the treatment, the patient or the client. And so that relational component does seem to add to the outcomes in terms of therapeutic improvement. But at least the data that we have now suggests that there is some relationship between the types of experiences that people have when they're on the substance and the therapeutic improvement they see afterwards. And so that's definitely, you know, appears to be a part of it. And, you know, the other stuff that's happening from a biological standpoint is also, you know, really interesting and still being investigated heavily. But, you know, we're seeing that the brain, in terms of its activity is changing, you know, across multiple different levels and different types of data that have been collected in this area using mri, eeg, PET imaging, and even in animal models where you're able to more at a fine grain, you know, investigate things like synaptic density, the appearance of new dendrites, and basically connections between neurons that seem to be forming, at least in these animal models. And then, you know, you take that along with all this other data that's accumulated on changes in brain activity related to mri, an eeg, and it starts to paint a picture of, you know, a drug that's having a biological impact on the brain that could be having these reverberating and persisting effects that could last weeks or months and interacting with, you know, this sort of therapeutic component that could potentially help support that process or even amplify some of the therapeutic benefits. So that, you know, is my best sort of crack at explaining how we think this works right now. But again, you know, that's something that's changing rapidly. We just finished a textbook for American Psychiatric association, which will be coming out in July, and that was a frustrating experience because, you know, just in the time that it took us to put the book together, you know, so much new work has come out. And so it's like stuff that you want to include, but you have to wait until the next edition, I suppose.
A
Well, I'm excited to see what comes next, and I'm also reassured that we're in such steady hands as your hands. I think your personal experiences and your thoughtfulness make you such a unique person to really lead the charge in all of this?
B
Well, I wouldn't say I'm leading the charge, but there's a lot of people working on this, you know, here at Hopkins, but all over the world. I mean, it seems at this point we're really excited to see that work is happening in places like the Czech Republic, in Australia. You know, work is happening in Europe and Denmark, UK and, you know, obviously all over the US as well. And so, yeah, I agree with you, though. I'm very excited to see sort of where the field goes and how this unfolds in the coming years, especially as it relates to, you know, whether or not we're going to be able to see improved treatment outcomes for these patients that are out there suffering now and who aren't necessarily getting the relief that they're seeking from the available treatments.
A
Wow. Thanks so much for educating us on all this. And thanks for spending the time with me today.
B
My pleasure. Thanks very much for having me.
A
Thanks for listening to the Thriving With Addiction podcast. If you found today's episode helpful, please follow and subscribe. Wherever you listen to your podcasts and share it with someone who might benefit, you can also connect with me on Instagram, LinkedIn and YouTube, or visit thrivingwithaddiction.com to learn more. Stay tuned for next week's episode. And remember, thriving is possible.
Date: July 14, 2026
This episode dives into the evolving science and practice of using psychedelics—particularly psilocybin—in the treatment of addiction and mental health disorders. Host Dr. Jonathan Avery (Addiction Psychiatrist) is joined by Dr. Albert Garcia-Romeu, Associate Professor at Johns Hopkins School of Medicine and Associate Director at the Center for Psychedelic and Consciousness Research. Together, they explore the history, potential, risks, and future of psychedelic therapies, separating myth from evidence while reflecting on personal journeys and professional perspectives.
Personal and Academic Background
01:15–06:12).“I had very much of this sort of timeless, spaceless type of experience… very much filled with emotion, positive emotion, you know, found myself crying even…” (Dr. Garcia-Romeu,
06:17)
Navigating Stigma and Support
08:25–10:45).“I also had my own, like, mental health struggles, a lot of depression and some substance use issues myself… noticing, you know, that I also had a predilection to that and I could potentially see myself getting caught in these cycles…” (Dr. Garcia-Romeu,
08:25)
Origins and Meaning of “Psychedelic”
12:12–16:42).
“He [Osmond] thought… a high dose of LSD or mescaline… could help them come around and make behavioral changes… what he found instead was… people were often coming back and reporting… insightful and meaningful experiences.” (Dr. Garcia-Romeu,
12:12)
17:01–25:40)“… the majority of these people, on average, are showing what you think of as salutary effects, like reductions in depressed mood, reductions in anxiety, improvements in cognitive flexibility.” (Dr. Garcia-Romeu,
17:01)
“What’s out there… is not always what is purported to be in there… sometimes there are research chemicals that we don’t have good knowledge about their safety…” (Dr. Garcia-Romeu,
22:51)
22:17).“There is not been a controlled clinical trial showing that it [microdosing] has any significant benefit in terms of mental health…” (Dr. Garcia-Romeu,
24:53)
25:40–32:17)“During those drug dosing sessions, people are usually kind of lying down on a couch… we wouldn’t be doing any sort of therapeutic intervention during the drug experience, but really asking people to have an introspective experience…” (Dr. Garcia-Romeu,
27:58)
34:38–38:45)“…there is some relationship between the types of experiences… and the therapeutic improvement they see afterwards.” (Dr. Garcia-Romeu,
34:51)
38:45–39:47)“It seems at this point we’re really excited to see that work is happening… all over the world. I’m very excited to see… whether or not we’re going to be able to see improved treatment outcomes for these patients that are out there suffering now and who aren’t necessarily getting the relief that they’re seeking from the available treatments.” (Dr. Garcia-Romeu,
39:00–39:47)
| Timestamp | Speaker | Quote |
|---|---------|--------|
| 06:17 | Dr. Garcia-Romeu | “When we sat there and actually did [metta meditation], I had very much of this sort of timeless, spaceless type of experience, was very much filled with emotion, positive emotion... found myself crying even, and was not expecting that...” |
| 12:12 | Dr. Garcia-Romeu | “People are finding new parts of themselves and they're having sort of new insights when they're under the influence of these substances... so that was the word [psychedelic] that [Osmond] proposed in 1957...” |
| 17:01 | Dr. Garcia-Romeu | “…the majority of these people, on average, are showing what you think of as salutary effects, like reductions in depressed mood, reductions in anxiety, improvements in cognitive flexibility, improvements in emotional regulation...” |
| 22:51 | Dr. Garcia-Romeu | “Buyer beware... what's out there... is not always what is purported to be in there. That includes sometimes... research chemicals that we don't have good knowledge about their safety and toxicity as well as the dose...” |
| 27:58 | Dr. Garcia-Romeu | “During those drug dosing sessions, people are usually kind of lying down on a couch... really asking people to have an introspective experience where they may lay down for six hours and listen to music and sort of just reflect…” |
| 34:51 | Dr. Garcia-Romeu | “There is some relationship between the types of experiences that people have when they're on the substance and the therapeutic improvement they see afterwards.” |
For the most up-to-date and detailed information, please consult your healthcare provider or the latest clinical research.