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A
Welcome to the Thriving With Addiction podcast, where we explore how recovery is not just about surviving, but about truly living. Each week, we'll dive into the science stories and strategies that help people and families heal from addiction and build healthier, more resilient lives. I'm your host, Dr. John Avery. Let's get started.
B
I'm John Avery, and welcome back to Thriving with Addiction. Today I'm joined by Dr. Yasmin Hurd. Dr. Hurd is the Ward Coleman Chair of Translational Neuroscience and the director of the Addiction Institute at Mount Sinai. Her multidisciplinary research investigates the neurobiology underlying substance use disorders and related psychiatric illnesses. A major focus of the research focuses on opiate abuse and the developmental effects of cannabis, which we'll talk about today. The group also conducts human clinical trials towards developing novel therapies for opioid use disorder. Dr. Hurd has been inducted into both the National Academy of Sciences and the National Academy of Medicine. Yasmin, welcome.
C
Thank you, John, for having me.
B
No, of course. It's great to meet you. And you're the expert in cannabis, and so we needed you to come on, since there seems to be so many different opinions about it these days or from the beginning of time, really. How'd you get interested, though, in the brain and cannabis? What brought you here?
C
It's actually had a long journey and a strange journey when I think about it. Um, I've always been interested in the brain from I was a kid. I always tell people I was a weird kid, just, you know, why do people act the way they do? And. And I knew it was from the brain. And so I started off being interested in actually neurodegenerative disorders when I was training to be a neuroscientist and in studying those, like, for example, Parkinson's disease. It's a disorder where the dopamine cells are damaged, and dopamine is a transmitter. That's not only for, you know, many people think about it for reward, but it's about motor function and attention. And we use drugs that target the dopaminergic system in teasing out the neurobiology of Parkinson's related disorders. And I was just fascinated by how these drugs, which turned out were like amphetamine and cocaine, completely changed behavior. Um, and that's when I started looking into drug. The neuroscience of drugs of abuse. And in studying adults with, you know, substance use disorders, I wanted to know, how do they get there? And looking at different risk factors as genetics and early life events. And one of them was early use of Cannabis. And so that's how I started down the cannabis path years ago now, when
B
I was becoming an addiction psychiatrist, a lot of people encouraged me not to, which is why I decided to become an addiction psychiatrist and, and study the stigma of addiction. What about on the research side were people encouraging of, of that transition from sort of the, you know, the bread and butter of the brain, Parkinson's, to trying to tackle and understand addiction?
C
I will tell you that I had previous people early that who I thought were going to be great mentors in my life who indeed said, do not go into studying addiction. And I didn't understand it, I think completely in terms of the degree of stigma, but I think that there is actually a greater stigma today still on the clinical side for, you know, clinicians like yourself compared to the, to the basic science. So the basic science of addiction, people get a lot of high, you know, high impact publications because using off the psychiatric disorders, you can model addiction more in an animal model than you can model, for example, schizophrenia. So you have now a lot of basic science and addiction is very well established, very well respected. But the stigma that comes with clinical substance use disorders, I think is still there, sadly.
B
Right, no, that's a good point. Sometimes you guys are saying to us or to patients or to families, this is really a brain disorder and we can really see everything that's going on. And sometimes we haven't quite communicated that well to people and family who are struggling. But the, the evidence is there.
C
Absolutely, the evidence is there. The, the problem still is that many people think of substance use disorders as a. Disorders of, you know, of lack of morals, lack of will, lack of that. And I don't think that they understand the nature of substance use disorders. Yes, you cannot develop a substance use disorder if you never consume the substance. So it's unlike, you know, Huntington's disease. You know, if you have the risk, if you. For Huntington's, the genetic risk, you will develop Huntington's. But if you never take an opioid, you will never develop an opioid use disorder, even if you have a genetic risk. So I think, you know, that is one of the reasons why I think our society, you know, look at people's substance use disorder, that they brought it on themselves. But many people go through the same thing of experimenting, especially during adolescence, with substances and other things. But a small handful get stuck in this and for no fault of their own, while others go on to lead, you know, very productive lives. And, and I think that that's, you know, the issue of substance Use disorders and psychiatric disorders in general.
B
And then among substances, that one study, as a neuroscientist, I think sometimes the opioids and the cocaines, amphetamines, they're sort of more accepted almost than cannabis. Right. I think you talked early on that in some of your early work, people argued against cannabis being accepted or understanding that's addictive and acts on those same reward pathways in the brain.
C
Yes. I remembered when we started our first studies with cannabis, and in our animal models, we studied thc, you know, the main psychoactive cannabinoid, and. And getting the first paper even published, because reviewers will come back. Why are you studying this? I mean, my grants and cannabis is not addictive. And these are themselves neuroscientists, other, you know, investigators. But they were like, you should just be focusing on cocaine and heroin. Those are the problems. And I was also looking at cannabis from a developmental lens, from a developmental perspective, because for me, it was, you know, is this really leading to risk for later challenges in life? And again, people were like, you should be studying. If you're going to study, study it in the adult brain. Why are you looking at it, you know, in. During development? And this whole issue of cannabis is so benign that it can have an elastic impact on the brain. And of course, many, as I said earlier, many people will experiment. You know, in college, people experiment with cannabis and alcohol and cigarettes, and so they think, oh, it's fine. I went on to become a neuroscientist, or I went on to become a lawyer and so on. So, you know, it's not a problem. And we now know that's not case.
B
That's right. So let's jump into why that's not the case. Let's jump into cannabis first. First, definitionally, cannabis, marijuana, weed, thc, cbd. Can you sort of unpack a little bit what we're talking about today?
C
You know, I mean, marijuana is a term definitely more colloquial use on the streets. You know, I call it cannabis because for me, how our society has changed it from being a, quote, unquote, recreational drug to voting for it to be medicine. And if that's the case, it's not marijuana that's medicine, quote, unquote, it's cannabis. But even that, I think many people don't understand that cannabis is a complex plant with, you know, over 140 cannabinoids and hundreds of other chemicals that we still have very little knowledge about. And yes, we know a lot about thc, and we know we're now learning More about the other, the second highest cannabinoid in the plant before cannabidiol, C, B, D. But cannabis is complex. And even if it's been around like many things for thousands of years, many people think that we know a lot, but we really don't. And we really don't. Because even one of the things that we started earlier to talk about, many people weren't studying cannabis because they thought it was not a problem. They never thought it really had any lasting impact on the brain. So why study it? And that's, and, and that's the issue. But I do want us to talk about cannabis and I want us to be specific and teach the public about cannabinoids, because it is THC that is the issue that we see for really psychiatric challenges and the growing psychiatric challenges with these high THC potency products that have been made as compared to cbd. So people put CBD in the context of being cannabis. And for example, a lot of the voting to legalize cannabis was really a vote to legalize cbd because when they saw that CBD was beneficial to treat, for example, these rare childhood forms of epilepsy, who wouldn't want to help the kids? And so a lot of the lobbyists used cbd, Charlotte's Web, as a way to say cannabis is completely, you know, fine, look at this, it helps these kids with epilepsy. But people weren't voting for cbd. The laws went voting for cannabis as quote, unquote, medicine. And so it's really important that people understand the difference between CBD and a cannabinoid and cannabis, the complex plant.
B
Right. And we'll talk mainly about THC today, but maybe talk a little bit just about cbd. I know you've done some research on it. I mean, as much as THC is everywhere, CBD is sort of everywhere. People are rubbing it all over their body and putting it in everything they drink. And you can go broke on CBD products, but it might have some benefit. Tell me what we understand about it.
C
I have to say I am extremely shocked with how C B D became this huge market. And I would have been a multimillionaire, actually billionaire if people had believed me. And I patented, allowed to patent cbd because in studying THC in our animal models, where we would see that adolescents, for example, rats that we gave THC to and study them in adulthood, they would self administer more heroin. So we knew that THC was changing our endogenous opioid system, making them more sensitive to opioids. But I wanted to, you know, was it really thc? Cuz in our human studies we studied cannabis and in our animal models we were studying thc and so I wanted to look at another cannabinoid and I said, let's look at cbd. And then no one knew what CBD was. It was actually very difficult to even get ligrant for our human studies. And we saw something different. We saw that CBD actually reduced heroin seeking in our animal models and then we moved it over to human clinical trials. So cannabinoids do differ. CBD is not cannabis, CBD is not thc. And I think that that again, like I said, is very important now people, you know, CBD now is in your coffee, your water, everywhere. I don't like that's shocking because we still don't know that much about cbd, even though I think that clearly it does not induce the psychiatric, you know, problems that we see with thc. But there's still a lot that we don't know. And to the point that you said, you know, it's very expensive, you know, a lot of these boutique shops that had originally popped up at CBD with these creams and everything, you pay a lot for that cbd. But the, the one issue on the negative side for CBD for me was that we did not realize that the cannabis industry would grow so fast and then use C B D to convert it to an intoxicating THC product. Because CBD is not intoxicating. We see that it reduces anxiety, but reducing anxiety does not, is not an intoxication. And that to me has been really disturbing because we took a non intoxicating product and made it intoxicating by adding the thc.
B
And then to clarify on the cbd, while it may help some things, it's not totally clear. It's, it's helping for all the reasons people are marketing it, especially at the doses they're marketing it in the ways people are using it. Correct?
C
Correct. I mean, I will be honest. In our clinical studies we use doses of like 400, 800 milligrams of CBD in the boutique shops. What they're buying, it's like 10 milligrams CBD.
B
Right.
C
So you know, I, when. So people should also know that in the US obviously cannabis is still illegal federally even if it's, you know, been voted to be legal in most states in the U.S. but there was an exclusion hemp derived products. So hemp has the plant as less than 0.3% THC. So they said okay for Those states especially that were used to making tobacco now they could like, you know, instill the agriculture. The farm bill allowed them to make hemp and hemp derived products. And hemp is cbd, basically these CBD rich cannabis plants. But they use chemistry to convert CBD to thc. And that is the problem. And also it's not just that they made THC from cbd, but the chemistry that's used. Also there are toxins in there, those chemicals. And that's one of the things. Also that's a problem that when you're using and buying these products, CBD products, you don't know what's in them.
B
That's a great point. There could be other stuff, there could be thc, even though. And they say there's not thc. And so let's jump into thc. Tell me about. And that's sort of what we, the psychoactive component that we've associated with cannabis, with marijuana for a long time. Tell us about that and tell us how the concentrations and potency of it have, have changed over time.
C
Yeah, you know, again, I think for me, and I think for a lot of people, I don't think anyone expected the explosion of these cannabis products in the manner which they have grown. So for example, you know, the plant, when people think about cannabis and like, you know, the hippie generation and Woodstock and So on, the TFC concentrations were like 2%. They kind of rose in a little later in the 80s, 1980s to like 4%. And they've continued to escalate so that today you have cannabis and you have THC products that have, I mean flower at least like 24% THC. That was not the original plant at all. But what's worse is that they have created strains of cannabis, strains that even has 60% THC. And now they have products that are the concentrates, you know, the dabs and so on, and they're vaped that can give 90% THC. Think about it. The original plant and what, you know, a lot of previous generations consumed when they experimented with cannabis was like a 4%, 2% THC product. And they would smoke and a lot of these kids in college and high school, they would giggle and share one joint. Now they're consuming by themselves, vape products. Vaping is also another thing. The, the way the means by which cannabis can get into your body, that they're putting THC in these huge hits in these concentrates, 90% THC, that is not the same drug. And I think that's another thing. I Wish our, you know, the public and politicians and policymakers would probably start calling it a different name. It is not the same cannabis. It is not the same drug. And so it's like think about, you know, when cocaine itself was very addictive and then came crack cocaine. They changed how, you know, how cocaine was consumed, and that even increased the addiction more. We know that as the concentration of any addictive substance increases, so does the addiction. And that's what's happened with cannabis. The thc, as they increase THC levels purposefully because they wanted to get more people addicted. We've actually this had more people addicted and more psychiatric and health issues out of it. So the purposeful creation of a product that's 90% THC, that has nothing to do with the original plan. I really do think we should be calling them a different name so people know what they're actually consuming.
B
Right. It's sort of marijuana on drugs. Basically. It's a whole new thing.
C
Exactly. It is the turbo marijuana. Turbo marijuana.
B
All right, we'll figure out the name by the end of this podcast.
C
I hope so. Yes, please, John.
B
But whatever we call it, it's dangerous. And so what you're seeing because of the availability, the access, the ease to use, you can use it in a stealth way with the vapes and the edibles, is that we're seeing. Well, what are we seeing? What's the evidence show in terms of who's getting addicted and the mental health and other consequences of it?
C
For me, one of the worst things that a society could do is to not raise healthy children, because they're the next generation and they reflect what's happening in our society. And today we see that these high THC products, more so than ever, have increased psychosis in young people. I think a new study even came out from Canada, and Canada, I think is important because they have a national healthcare system and they legalized cannabis before the US And I think people don't realize it takes time to collect data to see what are the impacts of anything in our society, any change. And the Canadian data showed now clearly that the more recent Earth cohorts, they show earlier onset of first episode psychosis and greater number of first episode psychosis than previous generations. That cannot happen because of genetics. It cannot happen. You know, and it they re. And it was related to cannabis use. And so for me, it's. I don't think that people realized that cannabis, this drug, that they thought, oh, you know, you giggled and that, you know, you may eat, you know, order pizza in the Night or something that that was would become this drug where we see a very close association with psychosis and schizophrenia. Especially the younger someone starts using cannabis, um, in, in terms of teenager and the frequency. And now we have kids that they call it wake and bake. They wake up. The first thing that they have to do is to consume cannabis. That is not normal. And we see now also even more in the emergency departments, more young people coming in with cannabis hyperemesis syndrome, meaning you know, this chronic vomiting and not nausea that never happened before with cannabis use. It really was like a spurious case that could occur. You see now data showing greater even cardiac issues in young people with associated with cannabis use that again never occurred. And even children obviously showing up in terms of the toxicity to emergency departments because they'll eat a gummy that their parent made a child left out. You never had those things before. It's a different drug that's associated with more health impact. And another thing that Canada, again, like I said, when you have a national healthcare and a national system that tracks a lot of things that we do in US they even see that young people are using the healthcare system because of cannabis more. So cannabis use is, has a much greater economic impact on the healthcare system than ever before. Those things are actual numbers. They're not, well, somebody making up, oh, that cannabis is so bad. This is not the same drug. And so we're seeing much greater health impact across all spectrum in the healthcare system, not only in psychiatry, but in our colleagues in terms of car cardiology. We see it absolutely obviously in emergency department and not just Canada. I should say that also the epidemiological studies in the US Also replicate that there's an increase in psychosis and other mental and health issues with teens and young adults using cannabis.
B
And are these harms, which I think even include lesser things like worsening of depression and anxiety and sleep disturbance, and certainly the risk of addiction and functional impairment. Are these harms seen even with occasional use? Is occasional use of this sort of turbo marijuana? I mean, it's obviously different than the occasional use back in the day. But does that even come with risks or what should we tell parents and kids as they try to navigate this?
C
I mean, the data shows that obviously the more frequent you use these high potency products, the greater the risk. But there are individuals still, there are risk in terms of even the infrequent use. And it's again because of the high potency of the thc. So, you know, a teen in a party there, somebody gives them this you know, 90% THC, they've ended up in the, in the hospital even though they're not frequent users of cannabis. The question that we have, and then you know, you raised in the sense of a lot of teens today, especially even adults, in terms of such a highly anxious world, teens are suffering from a lot of, you know, social media, this, that, that their, their world is very stressful. And many of them, like adults, say they use cannabis to alleviate their anxiety. But all the data shows that it is exacerbates and worsens it to a point where they end up in the hospital, they need medical treatment for their anxiety. And yes, it's a, it's a, it's a, it's a perplexing thing for people who say, oh, you know, our endogenous cannabinoid system is indeed important for regulating our stress response. It does. Our endogenous cannabinoid system is like a break on our stress response. But with chronic cannabis use it takes away that break. So now it become, it's like a, a fast car on the highway. It just becomes, it's an excessive anxiety that they, they feel and then they're like, oh, I need more cannabis. But they don't realize that the more cannabis they use, it's this ugly cycle. It just exacerbates the anxiety and the other mental health challenges. And that's the thing, as you know, with mental health issues, people can't sit back and see that. And that's the problem, right?
B
It's, it's both hijacks reward pathway. But then this withdrawal state that you enter really propels you forward because it's, it's just so unpleasant. And maybe speak to that a little more. What is it doing under the brain for your, for your research and what
C
you know, you know, the research shows that you know, chronic cannabis use or high, high potency products does even change the structure of your brain cells. The structure that stays with when we started the adolescent exposure and look in adulthood. So it's not a make believe thing. It changes the structure of your cells. It also changes the re. How quickly your stress system reacts in a negative way. So all these stress related. Your, your stress hormones, the genes that regulate a lot of the stress response, they are very high especially when exposed to high potency THC products. And yes, you know, withdrawal for cannabis as you know is actually one of the worst of many of the substance use disorders. You know, the depression, the sleep. Sleep is a huge aspect of many mental health disorders, actually many disorders. And I think that that's one of the things as well. But, you know, the withdrawal from cannabis impacts sleep tremendously. So again, many people think that cannabis is benign. Nothing is benign if it causes such huge impact on, on brain cells, on other cells in the body as well, but on the behavior and the long term effects that we see. And from a research perspective, you know, my question was, what maintains this? Why is it there? And we could see that these epigenetic changes and epigenetics, as you know, you know, we inherit the DNA sequence from our parents to, you know, to determine, you know, everything in our, in our bodies and brain, but the environment can put tags on those DNA so that genes that should be turned off are now turned on and vice versa. And we see that developmental exposure to, to THC changes the epigenetic platform or the signature in our brain. And that signature, interestingly, looks like what we see in aspects of schizophrenia when we look in the brains of people who were diagnosed with schizophrenia. And it changes those epigenetic changes linked to how the cells communicate at the synapse. So these are things that are not, you know, fiction. These are actual scientific facts. High potency THC impacts the brain. It impacts fundamental biological processes. That does have a long arc. Does it mean that you can't go back to normal? No. The one thing that I will say that when we saw that these changes were mediated by these epigenetic mechanisms, I actually was very hopeful because unlike genetics, you can't change your, the, the things you inherit. But epigenetic mechanisms are reversible. And so that to me gives hope. And that's why the earlier someone stops using cannabis, make it, try to make it through that really tough withdrawal period. There is hope. And you know, obviously on a research level, we're trying to see how we can target these epigenetic mechanisms. We can target them in an ML model and reverse the, you know, bad behavioral outcomes of developmental cannabis use. But trying to find ways that we can do that in humans in a healthy way. Way.
B
Right. And what about the person that says, all right, Dr. Her, Dr. Avery, I get it, kids shouldn't use weed. Their brain's developing. It is all these changes. But as an adult, I hear all the worry about alcohol and weeds everywhere these days. Isn't it safer if I just smoke a little bit of weed instead of drinking? I mean, holiday parties this year in New York, I heard there were so many that actually were serving not no alcohol or less alcohol, but they were serving marijuana products to adult adults.
C
Yeah.
B
And there's this Sort of this perceived safety more maybe even on the adult side. What would you say for the adult, casual or interested user too?
C
Yeah, I mean, the adolescent brain. Absolutely. And young adult brain are much more vulnerable to cannabis than the fully mature brain. Every data shows that really. However, even adults, because of this high potency THC products are, are having mental health issues then. So I don't want to make people to think it's only the teens and only young adults, the mature brain as well. And alcohol is one of the worst drugs, you know, substances, I should say, in our society, which creates a lot of health issues. I think everyone has to think about what they're consuming or putting in their bodies. If you are at a party often many people at a party are not drinking grain alcohol. You know, many people are. The same thing with cannabis. What kind of cannabis product are you putting in your body as an adult? You should do the same thing in looking at these products. What is the concentration of thc? To me, it's knowledge. People have to understand that our society have become guinea pigs for these companies that create these high TFC products. We are their guinea pigs. We have not done that with, you know, nicotine, the tobacco. They never made the nicotine higher. Yes, Juul made these, you know, food products which got teens and so into it. But that's what the cannabis industry has done. They have increased the THC concentrations that even at the adult brain is also vulnerable. So, you know, alcohol or cannabis, for me, it's like it's, I always say, is it, you know, do you want to jump up the fifth floor? Do you want to jump off the third floor? You know, it's, you know, nothing is, say, without harm. But we do know that the THC products today are not the same. They are manufactured to create addiction, not because otherwise there was no reason for them to change the amount of thc. And not only do they increase addiction risk, they also have increased the, the risk for other mental health illnesses and other physical illnesses. And yes, I'm sure, perhaps the industry that was not there thought. But that is what has happened.
B
Right. But it's encouraging if someone's listening to this and trying to stop that. A lot of the brain changes seem potentially reversible, at least the epigenetic ones. And then what do we know about treatment if someone's in trouble? What are some of the options available to get to the other side of it?
C
Today there are no pharmacological treatments as yet. There are a lot of, you know, studies in the, in the pipeline for trying to develop new treatments for substance, for cannabis use disorder. But there are a lot of behavioral treatments that are out there for me. There are more and more clinicians that recognize cannabis use disorder, motivational behavioral therapy. There are a lot of behavioral therapists that, who can help. So there is hope. And those, those behavioral therapies have worked. It's just to stick it out, especially during the withdrawal period that I know a lot of people feel that they can't make it through, but you can, you absolutely can.
B
Right? I think there's good psychological treatments. There's 12 step treatments. Unfortunately no medications quite yet like we have for alcohol, nicotine and opiates. But hopefully with time, some, some pharmacological support and sometimes it's just treating the underlying psychiatric conditions that have developed or contributed as. As well, I imagine.
C
Exactly, exactly. Coming back to anxiety, there are treatments that are well known for many years that, you know, psychiatrists can prescribe for you if you have. If the underlying issue is anxiety. The same thing for depression. There are, you know, we have pregnant women taking cannabis to, to, you know, treat their nausea and even their anxiety is also during pregnancy. There are medications that have been well studied for the impact on their fetal and their children, alcohol that show that they're safe. There are many safe medications that already exist. So kind of think about what your underlying reason was to even start and even what might have developed due to the cannabis use. But there are medications out there that are well known to, to alleviate those symptoms.
B
Right. And I guess the other thing we have to think about in terms of changing all these behaviors is, is how do we address this at a societal level, how we talk about marijuana and media and culture and the regulations. We need you basically talking to everyone all the time. But what would you recommend in those spheres?
C
You know, sadly, the, the horse had left the barn with these high potency products. The question is, how do we as a society bring back safety? We wear seatbelts. There are laws about seatbelts. Why are there not laws about the types of products that we now know cause harm? I understand we will. You know, we're never going to make cannabis illegal, but make safe products that are well studied, that they must fit a certain level, that everybody can just make these, these high potency THC products that we know cause harm. Those are the things that policymakers and the public needs to understand and demand of their politicians. The same thing. There's now, you know, bills on the capital being discussed about closing the hemp loopholes where people made, where Industry made these intoxicating Delta 8, 9 THC products, Delta 8, Delta 10 THC products from CBD. We can close those loopholes, but it's not a society. They. For the first time in our history, they were. Our public was asked to vote that cannabis or anything was medicine before we used to have to go through FDA products, evidently a pathway to say this is medicine. Cannabis is not medicine. It has medicinal properties for some conditions like, and, you know, certain products like obviously epidiolites for epilepsy, but is specific for those. And that's the thing that we need more research. So to me, the public, we should be pushing our policymakers and politicians to create and demand some industry safer products. Our society and our kids and everything deserve that.
B
You sort of alluded to it, and I don't think it's talked about too much, but there's sort of like a big marijuana lobby and like there is big tobacco. And I don't think that's quite been named as regularly as sort of the big tobacco.
C
They're the same and they're the same. Exactly. They are the same. And this is the issue. It's about money over lives. And especially for cannabis. It's not that, you know, people always say, oh, but cannabis is not like opioids that, you know, overdose that, you know, I can overdose deaths. But you're getting lifelong mental health outcomes from cannabis. And that to me is equally killing off, quote unquote, a large part of our society. That too is wrong.
B
Well, Yasmin, I really appreciate you taking the time to share all this with us today and keep doing the good work helping us understand cannabis and all these different topics in addiction.
C
Thanks, John, for having me.
B
Thanks.
A
Thanks for listening to the Thriving with Addiction podcast. If you found today's episode helpful, please follow and subscribe. Subscribe wherever you listen to your podcasts and share it with someone who might benefit. You can also connect with me on Instagram, LinkedIn and YouTube or visit thrivingwithaddiction.com to learn more. Stay tuned for next week's episode. And remember, thriving is possible.
Thriving with Addiction with Dr. Jonathan Avery
Episode: What We Get Wrong About Cannabis with Yasmin Hurd
Guest: Dr. Yasmin Hurd
Date: April 21, 2026
In this episode, Dr. Jonathan Avery is joined by renowned neuroscientist Dr. Yasmin Hurd, director of the Addiction Institute at Mount Sinai, to unravel the misconceptions about cannabis. Their conversation covers the evolving science behind cannabis, the profound changes in potency over time, the differences between THC and CBD, the real risks of high-potency cannabis on mental health—especially for youth—and the societal and regulatory challenges in addressing "turbo marijuana." Dr. Hurd translates dense neuroscience into practical, urgent advice for individuals, families, and policymakers.
Early Interest in Neuroscience:
Dr. Hurd was fascinated from childhood by the question, "Why do people act the way they do?" (01:24)
Transition into Addiction Science:
Initial focus on neurodegenerative diseases (like Parkinson’s) expanded into substance use after noting dopamine’s role in both movement and reward.
Cannabis and Risk Factors:
Studying addiction led her to underlying factors, including genetics and early cannabis use.
Academic and Clinical Stigma:
Both researchers and clinicians have historically discouraged studying or treating addiction, though basic science is now better respected.
Moral Model Persistence:
Many still believe addiction is a moral failing, not a brain disorder.
Cannabis Underestimated:
Early reviewers doubted cannabis was addictive, prioritizing cocaine/heroin studies.
Nomenclature and Complexity:
Cannabis (the plant) contains 140+ cannabinoids; marijuana is a colloquial term; THC and CBD are the most researched.
Political and Medical Confusion:
Votes to legalize "cannabis as medicine" often conflated THC with CBD (the non-intoxicating component).
CBD’s Rise:
Dr. Hurd’s early research showed CBD may reduce heroin seeking, differentiating it clearly from THC.
CBD Hype and Dosing Reality:
Most commercial CBD products are extremely low-dose compared to research trials (10mg vs. 400–800mg).
Conversion Loophole:
Some products chemically transform CBD into intoxicating THC, with little regulation and possible contaminants.
Dramatic Change in Potency:
1960s–70s: 2% THC
1980s: ~4% THC
Today: Flower products at 24%, concentrates up to 90%
Consequences of High Potency:
Modern cannabis is fundamentally different, “turbo marijuana.”
Psychosis and Youth:
Canadian data shows earlier and increased first-episode psychosis linked to cannabis.
Hyperemesis, Cardiac Risks, ER Visits:
Rise of cannabis-induced vomiting and heart issues; even accidental child ingestion via edibles.
Healthcare System Burden:
Not just psychiatric, but cardiology, ER, and economic impact—mirrored in US and Canadian data.
Risks Even with Infrequent Use:
Even rare use can be dangerous with today’s high potency products.
Worsening Anxiety and the Vicious Cycle:
While users claim relief, chronic use actually removes natural stress “brakes,” ratcheting up anxiety.
Biological Impact:
Withdrawal:
Hope for Reversal:
Is Adult Use Safer?
Adults less at risk than youth, but high-potency THC still causes real harm—mental, physical, and addictive.
Industry Motivations:
The cannabis industry purposefully raises potency to drive addiction.
Memorable Metaphor:
"Do you want to jump up the fifth floor? Do you want to jump off the third floor?... Nothing is... without harm." (31:02, Dr. Hurd)
No Approved Medications Yet:
Behavioral therapies (motivational/CBT/12-step) are effective; withdrawal is tough but possible to get through.
Treating Underlying Conditions:
Anxiety/depression often co-occur; treat these as well.
The Regulatory Failure:
“Big Marijuana”:
Medicinal Properties vs. Medicine:
Cannabis has medicinal properties for some approved conditions (e.g., Epidiolex for epilepsy), but has bypassed rigorous FDA processes for most uses.
| Time | Segment/topic | |----------|---------------------------------------------------------------------------| | 01:07 | Dr. Hurd’s entry into brain and cannabis research | | 04:41 | Moral stigma and societal misunderstanding about addiction | | 07:56 | What is cannabis? THC vs. CBD vs. the plant | | 10:53 | CBD’s distinct effects and rise in popularity | | 15:08 | How THC potency in cannabis has changed over decades | | 18:33 | Rise in adolescent psychosis, ER visits, and other health consequences | | 22:45 | High-potency risks with even casual/occasional use | | 25:02 | Brain changes: structure, epigenetics, and recovery potential | | 28:58 | Alcohol vs. modern cannabis for adults | | 32:10 | Hope: Treatment options and withdrawal | | 34:45 | Societal-level policy and responsibility | | 36:49 | The reality of the "Big Marijuana" industry’s role |
Dr. Hurd’s message is grounded, urgent, and compassionate: today’s high-potency cannabis is not the relatively benign drug of prior decades. The science is clear—there are significant risks, especially for youth and even for adults. As policies shift and the cannabis industry evolves, individuals and society must be better informed, advocating for regulation and safety, and recognize the reality of addiction and mental health consequences. Early cessation leads to recovery, and with the right support, thriving after cannabis use disorder is possible.