Podcast
Y Combinator Startup Podcast
Hosted by Y Combinator · EN
We help founders make something people want. The Y Combinator Podcast is where builders talk about building. From the earliest days of an idea to scaling a company that changes the world, YC partners and founders share real stories, lessons, and tactics from the frontlines.
71episodes
Episodes
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Garry Tan: Own Your Intelligence
Yesterday00:42:07Summary readyThe next generation of startups will be built by smaller teams than ever before.At Startup School 2026, YC President & CEO Garry Tan explains why we're entering the era of personal AGI: AI agents that run on your own infrastructure, compound your knowledge over time, and dramatically increase your ability to build. He shares the tools and workflows he uses every day, why every founder should own their intelligence instead of renting it, and what it means to build under your own power.Transcript: https://www.ycrootaccess.com/p/garry-tan-own-your-intelligence
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Building the First Data Centers in Space
2d ago00:36:13Summary readyPhilip Johnston is the co-founder and CEO of Starcloud, the company building data centers in space. In November 2025, Starcloud launched an Nvidia H100 GPU into orbit and trained the first large language model in space. They've since raised $200 million, hit a billion-dollar valuation just 17 months after YC demo day, and filed with the FCC to deploy 88,000 more satellites. In this episode, Philip walks us through their wild origin story, the engineering challenges behind the Starcloud-1, why they booked a SpaceX launch before they even knew what they were building, and how data centers in space make sense both economically and politically.
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Waymo Co-CEO Dmitri Dolgov: "Move Fast And Ship Safely"
3d ago00:49:24Summary readyWaymo’s first autonomous demo took eighteen months. The product took fifteen years. Today, the Waymo Driver runs 500,000 trips a week — four million fully autonomous miles across fifteen cities, with 17 times fewer serious-injury crashes than human drivers.At Startup School 2026, Waymo co-CEO Dmitri Dolgov shares the seven lessons behind that journey, from bridging the gap between a demo and a real product to building systems that can safely operate in the physical world.Transcript: https://www.ycrootaccess.com/p/dmitri-dolgov-seven-lessons-from
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Patrick Collison: "What If You Succeed?"
4d ago00:30:59Summary readyIn 2009, Patrick and John Collison went to Startup School in Berkeley, got sushi in Potrero Hill afterward, and decided on the walk home to start Stripe. The reasoning, as Patrick remembers it, was that “we might as well because it probably won't be that hard.”It took two years to launch.Seventeen years later, at Startup School 2026, he talks with YC's Harj Taggar about dropping out of MIT twice, why founders should ask what happens if they succeed, and what Stripe's own data says about the best time to start a company.
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Jeff Dean: The 1% Rule for Building in AI
6d ago00:57:06Summary readyIn 2001, Jeff Dean and Sanjay Ghemawat did the math and realized Google’s entire search index would fit in RAM — then shipped it in a few days, and search got fast. In 2013, another napkin calculation showed that three minutes of daily speech recognition per user would require doubling Google’s server fleet. That one became the TPU. At Startup School 2026, Google’s Chief Scientist talks with YC’s Diana Hu through the thought experiments behind both, why inference hardware is the next specialization, and where two or three people in a room can still win.Transcript: https://www.ycrootaccess.com/p/jeff-dean-the-1-rule-for-building
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Alexandr Wang: “This is a Once-in-a-Civilization Opportunity”
1w ago00:32:09Summary readyAlexandr Wang's advice to his 18-year-old self: develop your own internal compass for how the future will unfold, and hold conviction in it against the noise. At Startup School 2026, the Scale AI (YC S16) founder — now leading Meta's Superintelligence Labs — talks with Garry Tan about rebuilding a frontier lab from scratch, why talent density compounds, and how to spot the exponential worth betting your twenties on.
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Blake Scholl: Breaking the Supersonic Ban
1w ago00:50:01Summary readyIn 1969, we landed on the moon and flew Concorde. Half a century later, we could do neither.Blake Scholl founded Boom Supersonic (YC W16), the startup building America’s first supersonic airliner, to change that. At Startup School 2026, he shares how a cardboard mockup with Office Depot seats became XB-1, the first independently developed jet to break the sound barrier, and why founders have to build for both the worst day and the best day.He also answers founder questions about teaching yourself hard things, breaking into hardware without the right resume, and finding work-life harmony while building something ambitious.
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Sam Altman: "Never a Better Time to Do a Startup"
1w ago00:39:00Summary readyIn 2005, Sam Altman was a Stanford sophomore in YC’s first batch, building a startup in a little Cambridge office while Paul Graham cooked the founders dinner. Twenty years later, as co-founder & CEO of OpenAI, he closed Startup School 2026 in conversation with YC's Garry Tan — on agents, ambition, and why the ceiling for what a startup can take on has never been higher.
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Boris Cherny: Building Claude Code
1w ago00:36:13Summary readyFresh off the launch of Opus 5, Claude Code creator Boris Cherny joins Diana Hu at Startup School 2026 to talk about what the newest models can do, how Claude Code came to be, and what it means to build products when the underlying capabilities keep accelerating.
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Jensen Huang: The Mindset That Built NVIDIA
2w ago00:48:59Summary readyNVIDIA started with the wrong technology, learned the right one from three textbooks bought at Fry’s, and went on to invent most of the major breakthroughs in modern computing.At Startup School 2026 at Chase Center, Garry Tan sits down with Founder and CEO Jensen Huang to talk about confronting reality, learning your way into new domains, and why resilience — getting through one day at a time — matters more than anything else.
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