I’m excited to have Ashley Koff, a registered dietitian with over 25 years of experience in functional and integrative nutrition, with me today for the second part of a two-part series.

In Part 1, we explained why your satiety hormones may be underperforming, what that means for aging and longevity, and what you can do today to optimize your metabolic health in a natural way.

In Part 2 today, we explore what your best shot for weight loss truly is, why people on GLP-1s lose hair, future options in the pipeline, and the problem with info-obesity.

Tips for Optimizing Your Satiety Hormones:

Get a structured assessment of your weight, body composition, and bloodwork
Ensure your meals are balanced
Include a variety of fibers to support your gut bacteria and hormone production
Pay attention to your meal timing and frequency
Prepare meals that you genuinely enjoy to reinforce your satiety signaling and prevent cravings

Bio: Ashley Koff

Ashley Koff is a registered dietician and who is the founder of the Better Nutrition Program (BNP), the nutrition course director for UC Irvine’s Susan Samueli Integrative Health Institute’s Integrative and Functional Medicine Fellowship, and a faculty member at the Integrative and Functional Nutrition Academy (IFNA), where she teaches “An Integrative and Functional Nutrition Approach to Obesity and Weight Management.”

She is also the author of the upcoming book Your Best Shot (HarperOne, Jan. 6, 2026). A practitioner for more than 25 years, Koff is leading a transformative movement in personalized nutrition, turning “better, not perfect” choices into practical, sustainable strategies that deliver real health outcomes. Through patient stories and personal experience, she shows that optimal health is not just possible — it’s essential to living your fullest life. Koff has been recognized as one of CNN’s Top 100 Health Makers, featured in InStyle as “Hollywood’s Leading Dietitian,” and selected as Westin’s global nutrition ambassador.

In this episode:

A five-part assessment to uncover whether your satiety hormone activity is suppressed, delayed, or dysfunctional
How weight and digestion are part of a larger ecosystem that impacts your entire health span
How GLP-1 agonists can create stress within the body
The differences between biosimilar and non-peptide GLP-1 medications, and what that means for your body
How meal timing and frequency, macronutrient balance, and varied flavors support hormone signaling and satiety
How “infobesity” creates confusion in midlife, making personalized nutrition essential
Why you need to assess your own body, rather than following generic rules

Links and Resources:

Guest Social Media Links:

Ashley Koff on Instagram

The Better Nutrition Program

Your Best Shot

Relative Links for This Show:

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Calocurb Clinical — Appetite & Craving Support

A practitioner-exclusive, plant-based supplement designed to enhance your body’s natural fullness signals (GLP-1 and PYY), helping reduce cravings and calorie intake. Available only through clinics such as the Integrative Health and Hormone Clinic. Visit us or order here: ⁠⁠https://ihhclinic.com/

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242: The Hormone Dysfunction Epidemic: What GLP-1 Drugs Reveal About Metabolic Health Part 2

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