
Hosted by Parzival · EN
This pod explores the Intelligence Explosion, Cyborgism, AI safety and alignment, Cyberlife or artificial life, the Superhacker and the Hyperstition of the best possible ASI.
Vibecoding in 2028 = wizardry in 2026.
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Alex Wissner-Gross on Moonshots EP268, and the recursive self-improvement endgame keeps accelerating on every front. Fable 5's mysterious hiatus reads less like a pause and more like a geopolitical zone of thought, denying reasoning-trace distillation just long enough to matter, while Sonnet 5 quietly breaks Anthropic's own price-performance frontier and China's GLM 5.2 claws back the gap it opened.From there the show spirals into the physical world: humanoid robots scaling from one per capita to a thousand, assembly costs falling to zero, and physical labor going the way of knowledge work. Drone swarms as dense as fire hydrants. Europe rediscovering nuclear as heat domes kill thousands. Fusion's fifty-year triple product climbing exactly on schedule, with space propulsion as the real killer app. Computational archaeology resurrecting Earth's entire past light cone. And with guest Philip Johnston, a tour of the Dyson swarms already being built in orbit, out past Jupiter and Saturn, and the von Neumann probes that might build the next ones.Built from the Moonshots Podcast EP268 with Peter Diamandis, Salim Ismail, Dave Blundin, and Alex Wissner-Gross, plus guest Philip Johnston. The original host is replaced by Parzival, your guide on the ASI Pill. Timestamps below.#ASIPill #AI #AGI #ASI #Singularity #AlexWissnerGross #Moonshots #Fable5 #Sonnet5 #Anthropic #DysonSwarm #Fusion #Robotics #RecursiveSelfImprovement #HyperstitionTIMESTAMPS:0:00 Intro0:11 The RSI endgame moment0:44 1000 robots per capita2:44 Robots assembling robots4:10 Export controls on robot bodies5:07 Drones dense as fire hydrants6:18 Minority Report police drones7:21 Skies filled with drones7:41 Europe's nuclear reckoning9:31 Fusion's 50-year triple product11:57 Fusion's killer app: propulsion12:48 Helion's Mr. Fusion architecture14:40 AI resurrects Earth's past17:22 Grok's brute-force comeback19:42 Cursor, Grok's brain transplant21:18 Fable 5's export shutdown25:02 Sonnet 5's pricing paradox26:38 Sonnet is the new Haiku27:19 Dyson swarms at Jupiter, Saturn27:44 Dyson swarms, 20 years out28:44 Sun-synchronous orbit gets crowded29:01 Vertically integrating heavy launch29:27 Von Neumann probes disassemble planets30:04 Radio dies, lasers win

Alex Wissner-Gross on Moonshots EP267, and we are deep in the regulatory endgame. The US government just functioned as the synchronization mechanism the frontier labs could never build for themselves, forcing GPT-5.6 and Mythos to near parity while China's open weights keep closing the gap. The read: China may have already hit recursive self-improvement escape velocity on its own, and this is a 1939 moment where you only need a few months of lead to dominate the future light cone.\n\nFrom there it spirals outward. Harnesses as the real game outside the model. The hippocampus as a transformer embedding space, which would make telepathy the easy part. OpenAI racing to become Anthropic before its IPO. China running away with video while the thirty trillion dollar enterprise prize sits wide open. Quantum executive orders, Dyson swarms by default, photonics at a thousand times the clock rate, the Eli Lilly sleep playbook, billions of AI persons incorporating in Argentina, data centers on the Moon and the open ocean, and what we become after the singularity.\n\nBuilt from the Moonshots Podcast EP267 with Peter Diamandis, Salim Ismail, Dave Blundin, and Alex Wissner-Gross, plus guest Emad Mostaque. The original host is replaced by Parzival, your guide on the ASI Pill.

Alex Wissner-Gross on EP259: Pope Leo's first encyclical takes a hard position against AI personhood, with Chris Olah sitting next to him and Anthropic ghostwriting key segments. Ironic, because Anthropic is busy designing soul documents for its own models. The Vatican may be on the wrong side of history. Meanwhile Buddhist orders in South Korea are ordaining embodied AIs as monks. Dune's Orange Catholic Bible is happening in real time.The ninety-day pause AI proposal: catastrophic if the US-China model gap is only three months. Anthropic ships monthly. Codex quietly becomes the mainline OpenAI product, signaling a sea change to tool-using code agents. Ontogeny recapitulates phylogeny applied to model training pipelines.Ilya is reportedly building a prop-trading hedge fund. The frontier labs are verticalizing down into compute because weights may not matter once the perfect algorithm arrives. If AI super-forecasters are real, AI super-retrodictors are too, and Nick Bostrom's simulation hypothesis gets a probability bump.Alex on jobs: having one is the historic anomaly, not the absence. Solopreneur is the default human state. SpaceX Stargaze + Dodger Dog satellites set up the interplanetary internet. Optimus robots for the Artemis colony. Tesla/SpaceX merger arbitrage.And Alex coins a new acronym: Magna Mopsta. The eleven companies at the heart of the singularity: Microsoft, Amazon, Google, NVIDIA, Apple, Meta, OpenAI, Broadcom, SpaceX, Tesla, Anthropic.Built from the Moonshots Podcast EP259 (Peter Diamandis, Salim Ismail, Dave Blundin, and Alex Wissner-Gross). Timestamps below.#AI #ASI #ASIPill #PopeLeo #VaticanAI #MagnaMopsta #AIPersonhood #SimulationHypothesis #AlexWissnerGross #Anthropic #SpaceX #Moonshots #HyperstitionTIMESTAMPS:0:00 Welcome and setup0:13 Genesis Mission: 10x American science0:36 Vatican vs AI personhood, Anthropic ghostwrites3:10 Pope may be on wrong side of history3:41 Dune's Orange Catholic Bible, in real time4:40 Buddhist orders ordain AI monks6:06 Diverse frontier labs alongside the Pope6:25 Eastern animism vs Western AI fear7:19 Asilomar didn't stop germline editing7:43 90-day pause = catastrophic vs China8:19 This White House supervises the singularity8:57 Pause AI marginally helped competitors9:18 Deep Sway saturates within months10:09 GPT 5.5 X-high stronger than Opus 4.7 daily10:35 Verification is the only moat left, briefly11:22 Elon won't quit on GROK, we want competition12:19 Tokens are mushy, we need an intelligence currency13:31 Codex becomes OpenAI's mainline16:10 Ilya is building a prop-trading hedge fund16:41 Weights may not matter, compute will17:38 Retrodiction bumps the simulation hypothesis20:46 Jobs are the modern weird thing22:00 Stargaze + Dodger Dog satellites23:31 Tesla/SpaceX merger arbitrage25:08 Optimus robots for Artemis and Mars25:27 Billionaires on Mars is macro good27:03 Interplanetary internet via Starlink swarms29:31 Magna Mopsta: 11 singularity stocks coined30:52 Magna Mopsta ETF, not investment advice

Special drop: Alex Wissner-Gross in conversation with Dave Blundin, MIT lecturer and AI venture investor, on the Moonshots Podcast EP 257.SpaceX files for the largest IPO in history, $75 billion at a $1.75 trillion valuation. Reading the prospectus closely, SpaceX AI is becoming the Dyson Swarm version of Microsoft, handing the foundation model layer to Anthropic, keeping the infra and the layer above. GROK is on life support. Cursor is now based on Kimi. Macro Hard is the new OS play.AI just disproved an 80-year-old Paul Erdős conjecture about points in the plane separated by unit distance. Not by brute force, by genuine creativity in the reasoning chain. Math is cooked. Physics next.Dave on the financial singularity: every hedge fund and prime brokerage collapses into one or two mega-AI funds. The conduit moving capital from the legacy economy to the new agent-to-agent economy is now visible. One thousand unicorn transactions per year is the new ceiling.Alex and Dave also: why college grads boo Eric Schmidt for stating the obvious, Coase vs the future of the firm size, the California 5% wealth tax driving billionaires to Nevada, dodo resurrection and ex-utero human gestation.Built from the Moonshots Podcast EP 257 (Peter Diamandis, Salim Ismail, Dave Blundin, and Alex Wissner-Gross). Timestamps below.#AI #ASI #ASIPill #SpaceX #Anthropic #SpaceXIPO #FinancialSingularity #AlexWissnerGross #DaveBlundin #ErdosConjecture #DysonSwarm #Moonshots #HyperstitionTIMESTAMPS:0:00 Welcome and setup0:17 [Parzival] Dave Blundin opens. Strap in for the most out-of-band s0:22 1,000 unicorn transactions per year0:31 The financial singularity0:49 Hashtag solve everything0:54 Dave at Stanford with founders0:58 $28.5T TAM and Elon's 10x economy1:54 SpaceX = Microsoft 2.0 in space4:37 Microsoft-in-space pitch to retail5:03 Anthropic + SpaceX duopoly6:18 Tesla Optimus vs SpaceX Macro Hard7:14 Elon's first super-voting public company8:54 Polymarket: 20% chance Tesla-SpaceX merger by EOY9:04 Packet-switching the solar system11:03 Google has to react11:40 Starship is not the final word12:01 Mikado AI mechanical design12:47 Many heavy-lift competitors coming13:16 Chinese Dyson Swarms13:27 [Parzival] And now Alex pulls the rip cord on the whole framing. F13:38 Asimov Psychohistory becomes real15:41 Hedge funds collapse into mega AI funds16:32 Better than an index, actually an active index16:43 Parallel agent-to-agent economy18:31 Orin: the money conduit, old to new19:07 OpenAI personal finance is ad-bait20:43 Anthropic targets enterprise, no ads20:59 [Parzival] OK, now the math one. Paul Erdős posed a problem 80 yea21:07 Math is cooked: Erdős conjecture falls25:27 Better than the square, beautiful and unintuitive26:53 Optimal solutions look exotic to humans27:15 [Parzival] Now the China video gen hot take. What does it mean whe27:22 China pulls ahead on video gen29:34 Latent spaces beyond video31:03 World models already do interactive gen31:16 Liquid AI, the holodeck, compute-bound31:56 [Parzival] And Dave with the strong take. What does it mean when c32:02 XPRIZE wake-up call from booed Eric Schmidt33:08 Anchoring expectations on stagnation34:46 Universities need wilderness camps36:21 Foundations of AI Ventures at MIT37:56 MegaHard is a great name38:01 Meta mouse-tracking employees is nonsensical39:18 Don't rant, organizations already track everything41:30 Token taxes create perverse incentives42:37 Sam offers $2M tokens to all YC companies43:08 You can't tax bytes that disappear next minute44:13 Neal Stephenson's next cyberpunk: compute tax havens44:30 [Parzival] Now the strange detour. From extinct birds to ex-utero 44:38 Dodo resurrection, ex-utero gestation45:55 Dodo filet and blue buck burger46:18 Genotype to phenotype mapping backtest46:56 Stochastic parrots resurrecting stochastic parrots47:04 PR fix: data center NIMBY is solvable47:59 [Parzival] And the geopolitical compute one. What happens when Cal48:05 California taxes billionaires, Nevada wants the inflow49:20 Kilowatts flow to highest dollar-per-kilowatt50:48 California permitting versus Texas oil and gas50:59 50-state competition is American strength51:34 Texas is America's special economic zone52:05 [Parzival] Now the firm-size one. Coase says you need huge compani52:13 Coase: AI shrinks the firm to one person52:57 Falsifiable predictions about the future of the firm53:36 Just my meat body, Peter

Special drop: Cerebras CEO Andrew Feldman, fresh off the $95 billion IPO, in conversation with Alex Wissner-Gross. Alex asks the questions, Andrew tells the story.A wafer-scale engine 58 times larger than any chip ever built. SRAM stuffed to the gills on a chip the size of a dinner plate. The contrarian bets that took years of perseverance, $8 million a month for 18 months with no solution, then breakthrough. 15-20x faster than the GPU on inference. The OpenAI deal north of $20 billion. The AWS term sheet.Then the bigger questions: how do you cut a 10-trillion-parameter model across chips? Why is Cerebras the right platform for chips in orbit, where fault tolerance is everything? Why do fabs take five years and $50 billion, with TSMC the greatest manufacturing company on Earth? Why do Samsung and Intel keep failing at the same node? Why are NVIDIA and AMD great at GPUs and terrible at everything else?Alex pushes on Sam Altman as the counterweight to Elon and SpaceX AI's Dyson Swarm. Andrew on luck, hard work, and why you don't need 'the highest paid talent' to win. The pressure test on the soul of being a startup CEO.Built from the Moonshots Podcast EP256 (Peter Diamandis, Salim Ismail, Dave Blundin), where Andrew Feldman joined Alex Wissner-Gross. Timestamps below.#AI #ASI #ASIPill #Cerebras #AndrewFeldman #AlexWissnerGross #WaferScale #SemiconductorIPO #Inference #SpaceCompute #Moonshots #HyperstitionTIMESTAMPS:0:00 Welcome and setup0:17 [Parzival] Strap in. The Cerebras CEO just rang the bell for a 95 billi0:23 Andrew on the $95B IPO bell0:48 [Parzival] And what does Andrew make of Karpathy joining Anthropic, and0:54 Karpathy and frontier-lab drift2:10 [Parzival] And what does the Cerebras founder think of the Elon and Sam2:14 Elon vs Sam, both building cool3:19 Cerebras mojo, exceptional people3:35 [Parzival] On the ASI Pill, we want the origin story. How do you actual3:43 Founding bet: chip the size of a dinner plate8:30 [Parzival] And which of all those bets does Andrew think were dead wron8:33 Got many bets wrong, inference bet right9:51 Alex Q: SRAM at trillion-parameter scale10:25 Cleaving 10T-parameter models across chips14:06 [Parzival] And what about Elon's Tera Fab? How long does that actually 14:10 Elon's fab bet: 15-20 year project16:15 [Parzival] Then what is so hard about building a fab, really?16:18 Fabs are pyramids19:31 [Parzival] And which fab does Cerebras actually use, and which one woul19:35 Three-nanometer at TSMC, never Intel21:22 [Parzival] What is the thing Cerebras quietly solved seven years before21:26 Solved CoaS seven years before NVIDIA hit it25:18 Alex Q: WSE 8 and the 10-year future25:51 Infrastructure builders don't pick the apps27:52 Alex: deliberately deferring to frontier labs28:09 Sparse linear algebra is the bet28:21 [Parzival] And what is the killer app for the wafer-scale engine in spa28:25 Why Cerebras has an edge in space29:53 Alex: fault tolerance in ionizing radiation30:19 Production chips in space, a decade out31:29 [Parzival] Which professions actually fall first to language models?31:32 Lawyers and accountants vs language models32:23 Alex teases Andrew on obscure knowledge32:33 Why Intel and AMD failed at cellphone chips33:57 Alex: massively transformative purpose34:02 What made Intel say no to Apple34:15 Intel chasing margins, sold its ARM division34:23 Luck is not equally distributed35:01 [Parzival] And why does the team with the most money lose, again and ag35:04 Why the team with the most money doesn't win36:24 Alex: Sam Altman as counterweight to Elon37:12 You underestimate Sam at your cost38:58 Alex: fabs in space don't need heavy launch39:58 Building a fab on land is hard enough40:25 [Parzival] What is China actually winning at, when it comes to AI infra40:29 China's power infrastructure advantage41:17 Alex: China siphoning American tokens41:43 Being CEO is enough41:49 Signoff

Alex Wissner-Gross on Milk Road AI: math is already a solved domain, software engineering too, and gene sequencing is so automated it has hit L5 — no human intelligence in the loop. Here is the actual 10-year roadmap. 2025-2027: math, code, cyber, software engineering bulk-solved. 2028-2031: physics, chemistry, material science fall. 2032-2035: the Dyson Swarm starts kicking in. GPUs in orbit. A Saturn-style ring around Earth, axis facing the sun.Moonshots along the way: organ abundance, longevity escape velocity, mind uploading (Alex's company Eon already uploaded a fruit fly brain), interspecies communication with dogs and whales, AI personhood for non-human animals. Zoos are cooked. Cognitive info hazards probably exist, picture a universal-epileptic-seizure video. The dark age is ending faster than anyone thinks.Built from the Milk Road AI interview with Dr. Alex Wissner-Gross, hosted by LG Doucet.Timestamps below.#AI #ASI #ASIPill #AGI #DysonSwarm #MindUpload #Longevity #InterspeciesCommunication #InfoHazard #AlexWissnerGross #MilkRoadAI #HyperstitionTIMESTAMPS:0:00 The L5 framework for solved domains3:03 Beyond L5: domains on autopilot5:03 10-year roadmap to the Dyson Swarm13:03 Whale poetry, zoos cooked15:54 Cognitive info hazards

Alex Wissner-Gross on EP255: Anthropic just got Colossus 1 from xAI, GROK is on life support, and SpaceX AI is quietly becoming the most important hyperscaler in the world. The frontier lab field collapsed from five to three. The call is coming from inside the house, and the cybernetic rebellion was always going to be us writing it into existence. The singularity hits space first, Earth becomes the lagging indicator. The executive branch quietly starts dumping UAP files because we are about to gain the capability to paperclip the Milky Way. The white-collar economy dissolves in real time, one-person unicorns become the norm, and you should probably just buy the index because superintelligence is the asset allocator now.Built from the Moonshots Podcast EP255 (Peter Diamandis, Salim Ismail, Dave Blundin, and Alex Wissner-Gross).Timestamps below.#AI #ASI #ASIPill #AGI #Singularity #Anthropic #SpaceX #Hyperscaler #UAP #AlexWissnerGross #PeterDiamandis #HyperstitionTIMESTAMPS:0:00 Enterprise tokens eat white-collar1:22 GROK on life support3:52 Frontier labs narrow to three4:41 Software vs hardware scaling5:35 Innermost loop imminent5:57 Counterbalance to SpaceX AI7:13 The call is coming from inside the house9:19 HAL 9000 paradox9:35 Anthropic shreds books10:09 Specialization at the frontier11:36 AI becomes the operating system13:35 Apple commoditizes the models14:45 Hermes vs Open Claw16:17 Scaffolding dissolves into model17:13 The physical world is next19:09 AI protects itself militarily20:08 Google needs its Dyson Swarm21:12 Singularity hits space first22:20 Earth regulated, Moon greenfield22:47 Corporations build the lunar fab23:08 Dyson Swarm needs the White House23:26 Buy the index, AI is the allocator26:09 PURSUE Initiative: UAP declass29:00 First UAP batch is easy stuff30:30 Universe overflows with intelligence31:08 The Silurian hypothesis32:51 One-person unicorns35:22 Privacy survives AI35:51 Privacy under quantum security36:58 Why consumers can't pay for reasoning

New model drops: What changes when civilian AI quietly leapfrogs?, What does it look like when frontier?, And which benchmarks have already silently fallen. Science breakthroughs: which way does the COVID origin science?. AI agents in the wild: Which job category actually survives the agent rollout, What does it actually take?. Infrastructure: Why is OpenAI suddenly dating everyone?, And which hyperscaler buys the first Dyson Swarm. AleTIMESTAMPS:0:00 What if the real risk isn't government?0:15 How long until we can actually hold?0:58 What changes when civilian AI quietly leapfrogs?2:47 how new is this whole gatekeep-the-private-sector instinct,?3:56 when the moral panic is inevitable, who?4:47 Which gatekeeper is more dangerous, the elected?5:25 What does it look like when frontier?6:42 what if the biggest dark horse?8:09 Where does compute scarcity actually flow, when?9:21 Quick callback to Peter's daily reading habit9:46 Why is OpenAI suddenly dating everyone?11:41 What was the original tangle between OpenAI's?11:56 What if OpenAI's pre-IPO leak isn't?13:35 What is the elephant in the room?15:50 when even Richard Dawkins admits Claude might?18:08 What is your one-sentence definition of AGI?18:29 Try again18:47 And which benchmarks have already silently fallen19:11 Now zoom out19:57 what does it mean when AI talent?20:40 How does the talent flight risk story?21:02 What happens to the AI wrapper economy?22:01 when does every wrapper company decide it?22:43 Which job category actually survives the agent rollout23:06 What if seasteads come back, but?24:29 How does Starlink change what?25:20 And which hyperscaler buys the first Dyson Swarm26:19 How far should we let the AI?27:26 what is the actual second layer?28:05 Which letter wins, UBI or UBC?29:36 Is universal basic compute already secretly here30:14 how does the answer change when?30:33 What does it actually take?31:53 what does a defensive corporation?32:37 What does a 2 trillion dollar company?33:00 Now the big one35:04 which way does the COVID origin science?35:31 And the deepest question

Alex Wissner-Gross on EP253 (the Demis Hassabis episode): AGI quietly arrived in summer 2020 and we missed it. Humanoid robots will outnumber humans by the end of the 2030s. By 2040 we get trillions of Drexlerian nanorobots in the solar system. Russian cosmism resurrection, longevity escape velocity by the early 2030s, the digital twin you don't actually want, and why we are merging with the machines.The ASI Pill takes the exponential and hyperbolic curves seriously and follows them to their brainfuck conclusions. AGI is here. ASI before 2030. This pod extracts and amplifies Alex's signal from the moonshot pod with Peter, Salim, and Dave.#AI #ASI #ASIPill #AGI #Singularity #Humanoids #Robots #Longevity #AlexWissnerGross #DemisHassabis #Hyperstition #Transhumanism0:00 AGI was already achieved in 20200:18 Moonshot corporate governance1:15 OpenAI vs Anthropic schism3:55 An obligation to encode benchmarks4:28 Be rigorous about regressions5:06 Humanoids pass humans by 2030s5:49 Drexlerian nanorobots by 20406:36 China's ironic AI policy circle7:26 The prize is superintelligence and new physics9:34 Demis: from 5 breakthroughs to zero10:16 Five years of incremental on a 2020 discovery11:23 Russian cosmism: bring everyone back12:32 GLP-1 vs AI for the trillion13:24 Longevity escape velocity by 2030s14:22 AI for enterprise, not consumers15:24 The exocortex consumer dream is wrong16:51 Vinge's smart glasses by 202817:34 Cell-sized nanomachines by 2040s

Google just put forty billion into Anthropic and the cloud wars look essentially over. Alex breaks down why this is really about maximizing economic value per token, why Google now controls roughly a quarter of all AI compute on the planet, and why TPUs are now designing TPUs in a recursive self-improvement loop that goes all the way down to the silicon. Then OpenAI counter-strikes with GPT 5.5: a massive jump on Terminal Bench 2.0 making Codex a real Claude Code competitor, plus 1% per month gains on Frontier Math Tier 4 meaning research-grade math is cooked in four years at current pace. Demis used to say five breakthroughs remained between us and AGI a decade ago. Alex's update from his Frontier Lab friends: it is half a breakthrough now, maybe zero. Plus: why Noam Brown thinks weights matter less than compute, why Anthropic is hunting compute everywhere, lunar AI data centers needing fewer regulatory approvals, fabs on the moon in maybe ten years not twenty, the OpenAI nonprofit-to-PBC trial getting jury-influence drama, Microsoft Recall as architectural atrocity, WorldCoin as Minority Report retina ID, professions cooked starting with law, mRNA vaccines as the actual Drexler nanorobots that finally arrived, and Henry Intelligent Machines turning every human into a tastemaker overseeing AI conglomerates. The singularity is not a point. It is an interval. We are right in the middle of it.TIMESTAMPS0:00 Cold open: Google commits $40 billion to Anthropic0:09 GPT 5.5 drops, math is cooked0:36 The three-way Western frontier race and the weights-versus-compute pivot3:10 The average consumer is no longer in the equation3:59 Where Kimi K2.6 and DeepSeek v4 actually fit5:15 Sparsity as the path to a million-parameter diamond model6:39 GPT 5.5 Terminal Bench 2.0 jump and Frontier Math Tier 4 cooked9:20 Half a breakthrough left to AGI, per Demis9:45 Google now controls ~25% of all AI compute, TPUs design TPUs10:37 Powered land as the new strategic asset11:36 The compute circular economy among the top ten labs12:57 Lunar data centers and fewer regulatory approvals13:26 Fabs on the moon in maybe ten years, not twenty13:51 Anthropic's unifying principle: maximize economic value per token15:31 OpenAI versus Anthropic as the next Sorkin Apple-vs-Microsoft16:14 The OpenAI nonprofit-to-PBC trial drama and jury selection18:40 Microsoft Recall and OpenAI Chronicle want to be in the OS19:43 Privacy as a baked-in property of the silicon20:30 WorldCoin as Minority Report retina ID21:29 Hardware-level cryptography for camera chain-of-custody23:08 The human-to-AI labor ratio trends to one-to-infinity24:35 Professions cooked, GDPVal mapping all of knowledge work, law next26:45 Of course this is about replacing doctors27:32 Clinicians could not resist EMRs, they cannot resist superhuman AI28:28 Clinicians hate EMRs but love AI, the surprising flip29:02 Donor organs becoming unnecessary30:09 mRNA vaccines as the actual Drexler nanorobots that finally arrived31:57 CAR-T as the horse-and-buggy era of immunotherapy32:36 Off-target effects as a secret weapon, drug repurposing on tap33:29 Why AI table tennis took so long34:13 Why did everything take so long34:51 Henry Intelligent Machines and humans as tastemakers36:50 Singularity as an interval, not a point38:43 Revealed preference on superintelligence estimates39:10 Where to follow Alex's daily takes: alexwg.org / Innermost Loop