Welcome to This Week in Pediatrics. This week we're covering 10 notable papers spanning new insights into genetic disease mechanisms, the push for population-based screening, and critical updates in clinical communication and global health. Let's dive in. [PAUSE] We begin with a look at the fundamental building blocks of disease, with a major study on genetic cancer risk and several basic scienc…

This week's papers:

From PCOS to PMOS: inclusion of the adolescent voice in setting clinical and research priorities. — The Lancet. Child & adolescent health 2026
Cost of health systems strengthening for small and sick newborn care in four sub-Saharan African countries implemented with NEST360: incremental cost analyses. — The Lancet. Global health 2026
Scavenger receptor class F member 2 is an intracellular receptor for hepatitis B virus. — Cell 2026
Screening Children for Early-Stage Type 1 Diabetes. — JAMA 2026
A New Type 1 Diabetes Diagnosis Paradigm. — JAMA 2026
Mitochondrial L-2-hydroxyglutarate is a physiological signalling metabolite. — Nature 2026
Pathogenic germline variations and cancer risks in pediatric patients referred for genetic testing. — Nature medicine 2026
Genome instability triggers intercellular DNA transfer between human cells. — Cell 2026
Advancing Indigenous Health Equity in Medical School Curricula. — The New England journal of medicine 2026
Childhood Vaccine Hesitancy. — The New England journal of medicine 2026