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Welcome to This Week in Pediatrics. This week we are covering ten notable papers spanning neonatal care and respiratory strategies, infectious disease interventions and long-term growth, and long-term neurodevelopmental and gastrointestinal outcomes in childhood. Let us dive in. We begin in the neonatal intensive care unit, where managing fragile infants requires balancing procedural risks with c…This week's papers:Empirical treatment with valganciclovir in infants living with HIV and hospitalised with severe pneumonia in Africa: a multicentre, open-label, factorial, randomised, controlled, superiority trial — Lancet 2026Hearing-Targeted Congenital Cytomegalovirus Screening: An 11-Year Experience — Pediatrics 2026Social Inequities in High-Risk Neonatal Care Delivery: Clinical Report — Pediatrics 2026Expert consensus on bedside transcatheter closure of patent ductus arteriosus in extremely low birth weight infants — Pediatric Research 2026Long-term neurodevelopmental outcomes after vacuum-assisted delivery: A population-based cohort study — PLoS Medicine 2026Diagnostic Performance of Fecal Elastase and Risk Factors for Exocrine Pancreatic Insufficiency in Children with Pancreatitis: An INSPPIRE-2 Study — The Journal of Pediatrics 2026In-utero HIV exposure and postnatal growth to 8 years of age: a prospective cohort study in the Western Cape, South Africa — The Lancet Child & Adolescent Health 2026Second- and third-line treatment options for refractory monosymptomatic enuresis in children: a scoping review — European Journal of Pediatrics 2026Impact of Respiratory Support Strategies on COVariability During Therapeutic Hypothermia in Neonates With Asphyxia: Data From the German Hypothermia Registry — Acta Paediatrica 2026Age-specific ETCOc measured by non-dispersive infrared spectroscopy predicts neonatal phototherapy — Pediatric Research 2026Listen at AudioScholar

Welcome to This Week in Pediatrics. This week we are covering ten notable papers spanning critical advancements in neonatal and perinatal care, cardiovascular and intensive care monitoring, and strategies for improving equity and long-term screening in primary care. Let's dive in. [PAUSE] We begin in the neonatal intensive care unit, where three recent publications highlight the delicate balance…This week's papers:Therapeutic equivalence of intermittent and continuous phototherapy for neonatal jaundice: a systematic review & meta-analysis with regression and trial sequential analysis. — European journal of pediatrics 2026Efficacy and safety of procedural sedation-analgesia during laser photocoagulation for retinopathy of prematurity: a systematic review. — European journal of pediatrics 2026Racial and Ethnic Variation in Outpatient Respiratory Outcomes in Bronchopulmonary Dysplasia. — The Journal of pediatrics 2026Caregiver-Reported Quality of Pediatric Primary Care Language Services. — Pediatrics 2026Update on Selected Adverse Events of Concern Following Immunization With Acellular Pertussis Vaccines, a Narrative Review. — Acta paediatrica 2026Respiratory evolution after antenatal betamethasone dose reduction in very preterm neonates: a post hoc analysis of the BETADOSE trial. — European journal of pediatrics 2026Prediction of future onset of allergic rhinitis and analysis of risk factors in children with food allergy during infancy. — European journal of pediatrics 2026Fluid balance during PICU stay in children after cardiac surgery with cardiopulmonary bypass. — European journal of pediatrics 2026A multivariate electrocardiographic predictive model for left ventricular hypertrophy in children with primary hypertension. — European journal of pediatrics 2026Screening for Neurodevelopmental Disorders in Japanese 18- and 36-Month Health Check-Ups: Utility and Reproducibility of the ESSENCE-Q. — Acta paediatrica 2026Listen at AudioScholar

Welcome to This Week in Pediatrics. This week we are covering ten notable papers spanning preventive health and vaccine implementation, advances in neonatal and infant intensive care, and practical updates in pediatric emergency medicine and gastroenterology. Let's dive in. We begin with a critical look at preventive health and immunization strategies, starting with a large-scale study published…This week's papers:Influenza Vaccine Effectiveness Against Pediatric Death in the United States: 2016-2025. — Pediatrics 2026Parenteral Lipid Dose and Bilirubin Neurotoxicity in Extremely Preterm Infants: A Factorial Randomized Trial. — The Journal of pediatrics 2026Diagnostic accuracy study assessing the ability of paediatric asthma scores to predict admission following initial emergency department bronchodilator therapy: a Clinical Asthma Scoring systems in Paediatric Emergency (CASPER) study. — Archives of disease in childhood 2026Respiratory Syncytial Virus Immunization Disparities in Mothers and Infants at the Birth Hospitalization: A Cross-Sectional Study. — The Journal of pediatrics 2026KP.2-Adapted BNT162b2 COVID-19 Vaccine Uptake and Effectiveness in Children. — The Journal of pediatrics 2026Comparison of Crohn's disease exclusion diet and exclusive enteral nutrition in prospectively followed paediatric patients with Crohn's disease. — Pediatric research 2026Home and in-hospital phototherapy as comparable select routine approach for neonatal hyperbilirubinemia. — Pediatric research 2026Cost-benefit analysis of nirsevimab for respiratory syncytial virus prevention in infants: a population-based study. — European journal of pediatrics 2026Multimodal neuromonitoring in neonatal hypoxic-ischemic encephalopathy and the association with neurodevelopmental outcomes: A Multicenter Study. — The Journal of pediatrics 2026Long-term recurrence and acute seizure clustering in children with convulsions with mild gastroenteritis: a systematic review and meta-analysis. — European journal of pediatrics 2026Listen at AudioScholar

Welcome to This Week in Pediatrics. This week we're covering 10 notable papers spanning neonatal care and preventive strategies, prenatal exposures and long-term offspring safety, critical updates in pediatric gastroenterology, and key trends in adolescent development and public health. Let's dive in. We begin with a critical look at routine preventative strategies in neonatal care, where two rec…This week's papers:Phase 3 Trial of Oral Infigratinib in Children with Achondroplasia — The New England Journal of Medicine 2026Prophylactic Dextrose Gel for Neonatal Hypoglycemia and Neurocognitive Function at 6 to 7 Years of Age: A Secondary Analysis of a Randomized Clinical Trial — JAMA Pediatrics 2026ESPGHAN position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction-associated steatotic liver disease — Journal of Pediatric Gastroenterology and Nutrition 2026Prenatal Acetaminophen (Paracetamol) Use and the Risk of Autism and/or Attention-Deficit/Hyperactivity Disorder Among Sibling-Matched Cohorts — JAMA Internal Medicine 2026Impact of Phototherapy Blanket Treatment on Need for Overhead Phototherapy in Term Infants-A Randomised Controlled Trial (The Babies in Blankets Trial-BiB Trial) — Acta Paediatrica 2026Impact of antenatal biological response modifying drugs on infant infection risk and vaccination rates: a national cohort study — Archives of Disease in Childhood 2026Safety of infant milks: Contamination with cereulide. A commentary by ESPGHAN (European Society for Paediatric Gastroenterology, Hepatology, and Nutrition) — Journal of Pediatric Gastroenterology and Nutrition 2026The frequency and characteristics of ultra-short celiac disease in children: A single-center experience — European Journal of Pediatrics 2026Hammersmith Infant Neurological Examination global scores for predicting neurodevelopmental outcomes after 2 years of age: A systematic review and meta-analysis — Developmental Medicine and Child Neurology 2026Tobacco Use Among Middle and High School Students: 2025 National Youth Tobacco Survey — Pediatrics 2026Listen at AudioScholar

Welcome to This Week in Pediatrics. This week we are covering ten notable papers spanning critical advances in neonatal development and monitoring, novel interventions for complex congenital and genetic conditions, and the long-term trajectories of pediatric diseases into adolescence and young adulthood. Let us dive in. We begin in the neonatal intensive care unit, where balancing immediate thera…This week's papers:Associations between fentanyl exposure, gut microbiome and neurodevelopmental outcomes in preterm infants. — Pediatric research 2026Therapeutic hypothermia at 35 weeks' gestation: navigating controversy between randomized evidence, real-world practice, and shared decision-making. — Pediatric research 2026Neonatal blood glucose monitoring using glucose estimation by phase delay between oxy- and deoxyhemoglobin. — Pediatric research 2026Barriers and Facilitators of Inpatient Vaccine Delivery at US Children's Hospitals: A Qualitative Study. — Pediatrics 2026Concordance Between Maternal and Infant COVID-19 and Influenza Vaccination Status. — Pediatrics 2026Non-invasive removal of the Smart tracheal occlusion device for fetal congenital diaphragmatic hernia: a single-arm, open-label, phase 1 study. — Lancet 2026Mavacamten improves energy balance in a pre-clinical model of RASopathy-associated hypertrophic cardiomyopathy. — Pediatric research 2026Evaluation of the effect of CFTR modulator therapy on lipid profiles in children. — Pediatric research 2026Biological aging and generational shifts in early-onset cancer risk. — Nature medicine 2026Posttuberculosis Lung Disease in Adolescents in Lima, Peru. — Pediatrics 2026Listen at AudioScholar

Welcome to This Week in Pediatrics. This week we're covering 10 notable papers spanning critical care innovations in the NICU and PICU, common diagnostic challenges from seizures to ECGs, and a look at complex care in immunology and oncology. Let's dive in. We begin this week in the intensive care setting, with several studies aimed at optimizing care for our most vulnerable patients. A major nat…This week's papers:Individualised duration of antibiotic treatment in culture-negative early-onset sepsis in late-preterm and term-born neonates in Denmark (DURATION): a multicentre, open-label, randomised, controlled, non-inferiority trial. — The Lancet. Child & adolescent health 2026Performance of a Pediatric Early Warning Score Among Children With Severe Acute Malnutrition. — Pediatrics 2026Dexmedetomidine use in Infants undergoing Cooling due to neonatal Encephalopathy (DICE trial): safety and pharmacokinetics. — Pediatric research 2026Correlation of Oxygen Saturation Index with Oxygenation Index in Congenital Diaphragmatic Hernia: in A Secondary Analysis of a Randomized Clinical Trial. — The Journal of pediatrics 2026Semiological features of epilepsy seizures and paroxysmal non-epileptic events in children: A systematic review and meta-analysis. — Developmental medicine and child neurology 2026Live viral measles-mumps-rubella revaccination and varicella vaccination in children and adolescents with juvenile idiopathic arthritis: a systematic review. — European journal of pediatrics 2026Guideline-Discordant Bronchiolitis Care in Community Emergency Departments. — The Journal of pediatrics 2026Parental Perspectives and Experiences with Genetic Testing and Surveillance for Cancer Predisposition in Healthy Young Children. — The Journal of pediatrics 2026Targeted efficacy of BCG Hsp70-anti-CD123 immunoconjugate in childhood acute myeloid leukemia. — Pediatric research 2026Don't Skip A Beat: Deliberate Practice and Mastery Learning of Pediatric Electrocardiograms. — The Journal of pediatrics 2026Listen at AudioScholar

Welcome to This Week in Pediatrics. This week we're covering 9 notable papers spanning advances in chronic disease management, key updates in prevention and public health, and a look at emerging diagnostic and therapeutic trends. Let's dive in. We begin with chronic disease, looking at new insights from basic science to long-term clinical surveillance. In *Nature*, a study offers a potential new…This week's papers:GPR15-guided CD8T regulatory cells control intestinal inflammation. — Nature 2026Bowel ultrasound scan in the management of pediatric moderate ulcerative colitis: The applicability of international bowel ultrasound segmental activity score. — Journal of pediatric gastroenterology and nutrition 2026Survivors of Cyanotic Congenital Heart Disease: A Review. — JAMA 2026Egg Allergy Prevalence Before and After Guidelines for Earlier Egg Introduction. — JAMA pediatrics 2026Rotavirus Vaccine Coverage and Potential Barriers Among US Children Born From 2007 to 2024. — Pediatrics 2026Inclusion of young adolescents in policy development for new tuberculosis vaccines. — The Lancet. Global health 2026Automated contactless radar-derived movement index for outpatient motor surveillance. — Pediatric research 2026Survodutide Once Weekly for the Treatment of Adults with Obesity. — The New England journal of medicine 2026Use of Leucovorin After the FDA Announcement of Its Use for Autism Spectrum Disorders. — Pediatrics 2026Listen at AudioScholar

Welcome to This Week in Pediatrics. This week we're covering 10 notable papers spanning the care of extremely preterm infants, a re-evaluation of common and future therapeutics, and new approaches to assessing and preventing chronic conditions. Let's dive in. [PAUSE] We begin in the NICU, with a focus on our most vulnerable patients: the extremely preterm infant. A series of papers this week pro…This week's papers:Novel activity and participation scales for children, adolescents, and young adults with postacute infection and vaccination syndromes and/or ME/CFS. — European journal of pediatrics 2026Comparing neuroprotective drug efficacy in rodent neonatal brain injury models. — Pediatric research 2026Atopic dermatitis. — Nature reviews. Disease primers 2026Early Amino Acid Intake in ELBW Infants: School-Aged Outcomes From a Randomized Controlled Trial. — Pediatrics 2026Respiratory trajectories of infants born before 26 weeks of gestation from birth to discharge: an exploratory analysis of a randomised controlled trial. — The Lancet. Child & adolescent health 2026Plasma signals of lung tumor promotion for molecular cancer prevention. — Cell 2026Randomised, Multicentre Clinical Trial Found That Hypertonic Saline Did Not Reduce the Length of Stay of Hospitalised Patients With Acute Bronchiolitis. — Acta paediatrica (Oslo, Norway : 1992) 2026Clinical pharmacology insights from recent cell and gene therapy approvals relevant to pediatrics. — Pediatric research 2026Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies. — Pediatric research 2026Clinical study: Cardiovascular outcomes after a 14-week exercise intervention in young adults born preterm. — Pediatric research 2026Listen at AudioScholar

Welcome to This Week in Pediatrics. This week we're covering 8 notable papers spanning surgical decision-making, care for our most vulnerable infants, and the future of molecular medicine. Let's dive in. [PAUSE] Our first theme covers clinical crossroads in surgery and screening, beginning with a major trial in The New England Journal of Medicine that addresses a long-standing question in pediatr…This week's papers:Human haematopoietic stem cells remember inflammatory stress. — Nature 2026Decompression with or without Duraplasty for Chiari I and Syringomyelia. — The New England journal of medicine 2026Coordinated regulation using small-molecule drugs enables controlled therapeutic genome editing and enhanced genomic precision in situ. — Science translational medicine 2026Fibroblast growth factor receptor inhibition for succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 2 trial. — Nature medicine 2026Prevalence of Cerebral Abnormalities in Children With Congenital Heart Disease: A Systematic Review and Meta-Analysis. — Pediatrics 2026Geospatial Indices of Neighborhood Environment and Preadolescent Behavioral Health Screening in Primary Care. — The Journal of pediatrics 2026Extended Continuous Positive Airway Pressure in Infants Born Preterm Decreases Intermittent Hypoxemia: A Secondary Analysis of a Randomized Controlled Trial. — The Journal of pediatrics 2026Urolithin A attenuates inflammation and enhances barrier integrity in an experimental NEC-in-a-Dish model. — Pediatric research 2026Listen at AudioScholar

Welcome to This Week in Pediatrics. This week we're covering 10 notable papers spanning new insights into genetic disease mechanisms, the push for population-based screening, and critical updates in clinical communication and global health. Let's dive in. [PAUSE] We begin with a look at the fundamental building blocks of disease, with a major study on genetic cancer risk and several basic scienc…This week's papers:From PCOS to PMOS: inclusion of the adolescent voice in setting clinical and research priorities. — The Lancet. Child & adolescent health 2026Cost of health systems strengthening for small and sick newborn care in four sub-Saharan African countries implemented with NEST360: incremental cost analyses. — The Lancet. Global health 2026Scavenger receptor class F member 2 is an intracellular receptor for hepatitis B virus. — Cell 2026Screening Children for Early-Stage Type 1 Diabetes. — JAMA 2026A New Type 1 Diabetes Diagnosis Paradigm. — JAMA 2026Mitochondrial L-2-hydroxyglutarate is a physiological signalling metabolite. — Nature 2026Pathogenic germline variations and cancer risks in pediatric patients referred for genetic testing. — Nature medicine 2026Genome instability triggers intercellular DNA transfer between human cells. — Cell 2026Advancing Indigenous Health Equity in Medical School Curricula. — The New England journal of medicine 2026Childhood Vaccine Hesitancy. — The New England journal of medicine 2026Listen at AudioScholar