From anesthesia decisions to ablation strategy, what really separates a good outcome from a great one in bone tumor ablation? This BackTable MSK Brief features an enlightening conversation between host Kavi Krishnasamy and bone ablation pioneer Dr. Damian Dupuy. They cover anesthesia choices for different patient scenarios, optimal procedural techniques and agent selection for bone ablations, and the combination of local and systemic therapies for oligometastatic and oligo-progressive diseases. The doctors also tackle myths and realities around thermal and cryoablation, examining both clinical trial data and real-world experiences.

Episode Outline

00:00 - Introduction

00:40 - Selecting General Anesthesia vs. MAC

03:30 - Approach to Multiple Bony Lesions in Metastatic Disease

07:27 - Ablation Confirmation and Techniques Utilized in Bone Ablation

09:00 - Research Insights Surrounding RFA in Bone

12:16 - Sclerotic vs. Lytic Lesions: Techniques and Considerations

14:47 - Skin Protection During Superficial Lesion Treatments

16:38 - Analyzing Clinical Trials: Motion and OPuS One

20:51 - Conclusion

Resources

Dr. Damian E. Dupuy, MD, FACR

https://www.linkedin.com/in/damian-e-dupuy-md-facr-6b080b1b/

Radiofrequency Ablation Provides Rapid and Durable Pain Relief for the Palliative Treatment of Lytic Bone Metastases Independent of Radiation Therapy: Final Results from the OsteoCool Tumor Ablation Post-Market Study

https://pmc.ncbi.nlm.nih.gov/articles/PMC10156864/

Cryoablation for Palliation of Painful Bone Metastases: The MOTION Multicenter Study

https://pmc.ncbi.nlm.nih.gov/articles/PMC8011449/