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The most expensive peptide in the world will do absolutely nothing for your skin if the cell underneath is dysfunctional. And that's exactly the part almost nobody talks about. Welcome to Biohacking Beauty, the podcast where we break down the real science of skin aging, longevity and performance without the noise. I'm Amitay Eshel, co founder of Young Goose Skincare. And today we're going deeper into something that completely changes how you should think about peptides and honestly, skincare as a whole. Because most people are buying signals, peptides, growth factors, exosomes, actives, but they're completely ignoring the terrain those signals are acting on. And if the terrain isn't healthy, if the cell is inflamed, low energy, not producing ATP properly, those signals don't just underperform, they do nothing. So today's conversation is with the incredible Chris Duffin. He's an engineer, a world record powerlifter, and one of the few people in the peptide space who actually think in systems. He's been working with peptides since 2003 and his core idea is simple, but I believe it's also a paradigm shift. The peptide is not the point. The terrain is the point. We're going to break down copper peptides, the healing peptide class, what's actually real versus what's marketing and how, how to build a system where these things actually work. Because your skin and your body are not separate from your entire biology. It's a direct reflection of it. And once you understand that, you stop chasing products and you start building skin that is functional or functioning as a younger tissue. So let's get into it. Okay, Chris, welcome. What a pleasure to have you here. Someone, I, I don't know when I started following you, but I am a huge admirer of your, of your mind, of the way you view fitness and the world. And it's, it's a truly great pleasure to, to have you here on the podcast.
B
I've enjoyed getting to know you this last month or so and having conversations and been looking forward to this.
A
Yeah, incredible. So, you know, the way I want to start our discussion is that the world is now obsessed with peptides to the extent that I think there are people who, this is now part of their Internet identity. But I think that when someone is truly a peptide master, I think they understand that peptides are not the point.
B
You are so spot on. So one, I am really mixed because I've been really excited about that. This has come into the common realm. I am someone that's been using peptides for 25 years. And it is something that I literally couldn't talk about because I own companies in the field and my advisors are like, you can't talk about that. That's like steroids because it's got a needle involved. And so this being commonplace because they are so powerful, you can do things that were impossible before with them. But at the same time, the mixed part is the fact that they're just part of a larger solution. They're a tool in a mix, and they won't do anything. For most people that I see on social media talking about them or interested in them, they will not do anything because it is a signaling molecule. And if you've got a house that's, you know, been demolished in a storm, let's say.
A
Yeah.
B
And we're. All we can do is send signals to the job site. And yeah, you know, the. The tower for the. That's. The cell signals are going through. Everybody's sending because it's. There was a storm. And that is a lot of people's body at that that are trying to do this, and they're not taking care of the fundamentals. That is literally, you know, calming that down. And it's like, why. Why in the world are you trying to jump on, like, Retitrutide and the Motsi and all this other stuff? And it's like, you're not even exercising regularly. Like, that is the number one biohack in the world, is to push against resilience. Like, what are you doing with your sleep? What do you. And I know that those conversations are so boring, but when you start mixing them together, because it's like, okay, what are the lifestyle factors? What are the nutrient factors? What are the supplementation? What is the. Literally the terrain that we're sending these signals through? Because if we've got all that interference going on, they're. Nothing's coming through. Nothing's getting to the job site, telling the foreman what to do. Like, you're just burning money, wasting time, and potentially doing negative things, actually, because some of these are really powerful with some of the stimulus that they can do in sending that wrong stimulus or sending the wrong stimulus in the wrong environment might have potential negative consequences. So. So, yeah, incredible mixed feelings about this because it's. I know I'm starting right into a rant here, but, like, all right, you've got the cellular terrain, We've got the raw materials that we need to use, then we have the signals. Then we have the ability to amplify those through additional modalities, like Red light therapy, shockwave, so on. And then we have to make all this stick. And that usually comes down to again the movement, these main signals into the body of training and load, like to get those changes. Because at the end of the day now we have to drive adaptation and adaptation happens from putting demand on the body in some way. And then that process happens. I mean, it's one of the most. This is the fundamental science behind exercise. Science is one thing. It's one word, the said principle specific adaptation to impose demand. And it's like we've got this magic molecule that's going to fix everything. Everybody needs to be on these five different peptides. And what's the perfect peptide for this and that? And it's like, well, it varies like from person to person, the different environment, the different issues that they've got going on. Like, there is no. There's a peptide plan or preptide protocol for X. Like, it doesn't work that way.
A
Yeah, I think, you know, Derek from More Plates, more Dates once said it best and probably like, you know, probably butchering. He. He said it like really well. He said there is no peptide that's going to fix bad sleep. Like, it's there. It doesn't fundamentals. And the thing is that you talked about red light, shockwave, all of that. I really think of a Tesla like an electric car. It's much easier to charge it to 50% than the last 20, 10% of charge. And that's when these modalities become extremely impactful. Because the last 30, 2010% of adaptation of charge, the. The help there is significant, but at the 50% there are. They don't matter. They literally don't matter. So what does matter? Like, yeah, I was going to say
B
it's another analogy to that is back to building this repaired house because I'm probably going to dive into that. Like, you'll see if you ever drive by construction in a couple of days, all of a sudden all the framing's up and it's like you can see the house, it's there, but then six months later, it's still not finished. Because all the finishing touches that getting from 98% to 100% takes forever doing all of that work. But man, up front, you're like, this thing's going to be done in no time. Look at that. Yeah, but I like the battery analogy. That's a good one.
A
No, no, no, I like your analogy and I'm going to actually use your analogy. I see your analogy and I raise you, you Know, a poorly built house and an incredible, incredibly built house can look identical. Yes, they can look identical. You know, you and I know people who look incredible, but their body is completely torn down by their. By the time they're 40, by the time they're 40, they need hip replacements and they cannot get their, you know, their endocrine system under control, et cetera, et cetera, et cetera. And there are people that would look not as good, but are going to be able to not only perform now, but also go through adversity, go through illness or whatever that is, and maintain optimal function well, well, well into their, you know, 70s, 80s, et cetera.
B
Off of that, you've got people that look good, let's say a business professional, they're in their 30s, they're working out, they're going out, taking clients out for dinner, they're driving hard in business. They've got all the things, they've got the fancy car, they've like, they're a hard driving professional across all realms. And then you get all of a sudden in 45, and it's like the things start crashing, you know, for this individual. Yeah. And all of a sudden it's like they're running their blood work, their lipids are out of control, they're pre diabetic, they've got brain fog, they're struggling, like doing the work that they did before because just the emotional resilience when things are bounced around, they can't handle it. They're having trouble getting through the workday. It's like, what is going on?
A
Yeah.
B
And just because they look good, they were pushing hard through all those years doesn't mean they weren't burning their system too hard. Like we have to have this balance and structure and that amount, that situation I described. What's wrong here? Well, they probably weren't getting sleep, you know, they were taking those clients out, they were drinking regularly because they were exercising. They weren't. Their bodies still look good because you can, you could still look good and not be taking, doing that. So they've got, they've got some toxic burden, they've got stress overload, they've got, they're, they've got a poor diet especially combined with this, like the work stressors.
A
Right.
B
This is that work stressor. So now they, they've had this GI leakage that they just didn't worry about because damn, they look fit. They were doing like they were the one everybody wanted to be at 35, but now it's this cascade. Well, what happened, you know, we had some leakage across that, that, that GI barrier, that cross linking in the gut. Well, what happens if we get some particulates, some toxins that are passing that barrier and this ties directly into peptides and we'll get there, but passes that barrier. Well, what's going to happen from that? Well, the immune system is going to respond. The immune system's responding to those. You get an overreaction. Now we start getting some inflammation, we start getting maybe some autoimmune conditions starting to develop from that inflammation. Now we've got. It starts affecting the cellular metabolic production of ATP. Don't feel it at first because they're cranking some. They've got their pre workout, they've got their caffeine, they're doing all the things to drive their business hard. They've got the stress and adrenals dropping on them because of the work that they do. Right. And they're pushing it and pushing it. And what's happening is we've got leakage, we've got inflammation. Well now that electron transport chain that develops all the power in that body, there's a five stage that drives and creates ATP at the end of this and that's leaking.
A
Shout out to the mitochondria.
B
That's right. I love where the research has come, particularly in the last five years. Like, oh my God, it is just. Absolutely.
A
Yeah.
B
I'm gonna stick on before I go on a tangent there.
A
Yes, yes, yes.
B
But we're starting to, to have some leakage there. This, where's this come out like 10 years later all of a sudden? Well, that is, that's metabolic disease at a cellular level. That's the brain fog kicking in because they're literally starving. They're their brain of ATP. And if, what happens, if they keep down this route like. Well, that is the root of a number of, of neurodegenerative diseases. Not all of them, but a lot of the research is showing that that is a metabolic disease. Like literally it was Approved last September, SS31, I can never say it died. Ah, screw that one up. He got approved for its first neurodegenerative disease. Of course it's a rare run like they always are. In this case it's Banff disease, but they're expanding and using other ones and it's literally treating that. This cardiolipin, that's this protein that's unique to the, to the mitochondria and it has the opposite electrostatic charge comes in and repairs it. But that stops the leakage, it stops the metabolic and ATP loss that is literally starving the brain of energy.
A
Right.
B
So we've got this huge cascade that's going, that's going on here. What are the drivers? Well, what are the drivers of sleep? Sleep affects digestion, the toxins affect digestion, the stress affects like all these things. And we could start throwing peptides at this so they feel good right away. What are we gonna do? It's 45, low energy, all this stuff. This is TRT all right, we're gonna slam some TRT, we're gonna put em on some MOT C we're gonna put em on a GLP and they're gonna just describe.
A
You described the birth of every TRT clinic in the world and the protocol
B
that they give makes them feel great for another couple of years but it doesn't resolve the base level issues and it's going to the casket. You're just pushing it harder. That's a harder on the performance stand. I mentioned right before this like a family that I'm taking on work for. I saw exactly what was being done. You know this is happens with some of the people with the best resources in the world and they feel great. Like peptides changed in this case changed like the world for them because all of a sudden they're very much this avatar kind of person of just a high profile group of people that are moving and shaking business celebrities in, you know, in the media all the time. They get on this exact same protocol, this high driven performance stuff which pushing the same thing again. Let's unwind this. What are we going to do? But we can use peptides to fictus if we do them right. It's the right approach, right layer. Like how do we, how do we do this? Like well we need to fix like the sleep issues, we need to fix the diet, we need to fix the toxins, we need to fix the stress. Maybe we need to teach breathing patterns and do all this sort of stuff. But we can accelerate and that's what peptides can do. So in that case like I would do an oral set of peptides because yeah, I'm probably run blood work. I'm going to have seen the inflammatory response. I'm going to have done and talk to the person and one of the things we're going to dive into obviously sleep and digestion, things like that. And this is certainly not the suggestion as a stock. I'm just, I'm just, I just made up an example on you know, on the call right here. Right. And so we might as we're doing those changes to accelerate that. We need to clean up those signals because we can put those performance signals in and they can kind of drive things. They can get through. You know, TRT is not a signal. TRT is a drug. It is the chemical doing the thing.
A
Yeah. It sits like significantly, significantly lower down that cascade. It basically is like a, you know, it's basically. Yeah, well, the TRT is the best example of trt, but like it's, it just forces the system to behave as it should behave, where it does. And it ignores kind of everything that happens before. That's why it works well, so well for so long.
B
For so long. It doesn't work permanently. That's the issue, especially the higher doses and the others. And the issue with like people going on at 35, 40, wherever, which this person probably did this avatar that I picked. Fun. Probably went on from these other reasons a little even earlier.
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29 years old.
B
Yeah, yeah. So they, they, they, they went on trt. And what has that done? Well, they've taken this dose once or twice a week. That's saturating the androgen receptors. It's keeping. Yeah. Testosterone on that receptor in the body, which is actually meant to be pulsatile. It's pulsatile with the circadian rhythm. So this has also helped break down that circadian rhythm and helped feed that sleep cycle issues that they've got. That's literally calcifying their pituitary. Right. Because that's happening now. We're also saturating those androgen receptors, which means they've probably been having to give blood or do something else because that has a negative effect on the erythropoietic signaling. So it's affecting, it's direct testosterone, but it's a signal too. And one of those is this signal that affects hermatocrit. And that ends up being why a lot of people end up coming off of that. I'm going to get back to what I would do to fix this in a minute. But this feeds into that because this is also that adrenal stimulus, all those things. And 10 years of TRT, even at a moderate high dose, not a, you know, an actual non TRT dose. There's a lot of people that say they're on TRT and they're running like performance dosages.
A
Yes.
B
But 10 years, 20 years, that's a long time, like to be pushing on your adrenals and all these other things and never giving those androgen receptors a, a rest, which also leads to metabolic issues. Because it raises your insulin resistance.
A
Yeah.
B
Right. And the thing is the studies weren't done for people being on testosterone for 30 or 40 years. Which if you went on at 29 or 35, you are going to be. Yeah, people don't think about that. You're going to end up with the same result as what a bodybuilder that pushes gear hard, steroids hard for, you know, five, 10 years, that runs into these issues because you're running into, you know, a moderate dose for decades. So here they are, that's happened. So we got to deal with all this. We've got broken circadian rhythm, we've got GI issues. How are we going to walk through this? We talked about the lifestyle, the other things. So let's talk about how they can all build a little bit. So obviously we need to clean up the diet. We might do some fasting even. I'm not a huge proponent of fasting. Not anti fasting, but in this case actually that can help get some breathing room for the gi. So just some lifestyle factors maybe we can put in there. Yeah, but we would, we would use some oral based peptides like oral BBC.
A
Right.
B
Oral kpv, oral ghk, cu.
A
Are you just like a caveat there, are you, are you suggesting people kind of avoid the additives that allow it to kind of go, you know, further down the gut that may cause like gut issues or, or are you pro additives that get it like to the small intestine better as far as the, the peptides. Yeah.
B
So like the, yeah. The BPC needs to be bound to an argonate salt. There's some particulars that need to be done with this. So you need to buy something. I, I've got one. It's not mine, it's by lvlup out of Australia. Really Great. There's other companies, so make sure.
A
Level up. Shout out to level up.
B
Yeah, level up. Yeah. I carry this because I need to be able to ship it to my clients. So I'm not here trying to pimp it. There's not much money in reselling supplements. It's a service like, hey, I've got it in stock and I can ship it to my clients when they need this.
A
Right.
B
This is not a ongoing thing. This is a period of time and if somebody's got autoimmune issues, almost always you'll find this correlated issue with the gut because this is the driver of some of those immune responses and that might have been kicked off from mold exposure from for example, that there's a lot of different avenues into causing that, that breakdown to start with. But we still have to fix it. And so we're going to mix in and I'm basically calling out the level up blend there. It's got lorazatide, it's got tributarine. So this is basically the. What is the fermentation process in the gut creates butyrate, which is one of, it's the. Your body uses to repair and actually does a whole lot of things. It. And then I would probably add in something like tudca. Tudca, yeah, that is. It's a synthetic bile duct fluid bound to taurine. But it has this big cascade on stress reduction particularly er, so indirectal plasma reduction. So it's er, stress but that's basically in your endothelial tissues.
A
Yeah.
B
So it bio signaling does a massive amount. So that would be in, in that protocol and that you know, for 45, 60 days is going to be, have a cascade of effects on this person, this avatar person that I just threw, threw out there. Because those things are also going to go systemic because they're also with this I described like they're going to be having trouble recovering from exercise at this point in time. They're going to have aches and pains, their joints are going to hurt. Like all this stuff has happened from this, this you know, scenario that I have created. So all as a whole they're feeling better because these peptides like they work systemically but we're fixing this driver of inflammation through the whole body. So that's going to start having a thing. This is all theory for me because the next part which is we see in that 60 days of an individual like this make far better response than if we were delivering those peptides injectably, which is more, you know, efficacy. I think it's there's a secondary impact through that vagal connection to the brain and then another secondary, you know, neurological cascade through the body. Because obviously we're driving down, attacking it through the gut. We're driving down the systemic inflammation faster. But this is game changing to have that approach during that period of time. Right? Yeah. Now once we've quieted the immune response that brought down the stress levels in the system, now we can start sending other signals in there.
A
Right.
B
We want to work on the sleep. We talked about the broken circadian rhythm.
A
Right.
B
So we're going to work on sleep habits. Obviously basic things like shutting down your work, keeping away from your phone and tech the last few hours, looking, you know, getting sunlight in the morning if we need to, it might be some moonlight at night. I don't want to get too woo woo on folks here, but some basic circadian a little bit. Yeah, some basic circadian reset principles and then we'll employ some things like hey, here's some magnesium and specific types of magnesium before bed because of the stress. Let's say with this. I would actually, I'll get to that. So we'll add glycine, would add glycine at that time. So glycine brings that core body temperature and helps with getting into sleep onset. Again, we're talking about a 45 year old that's had a lot of stress and oxidative burden that happens. So when we have that cycle of that leakage from that, we've got the inflammation, we've got leakage of that electron transport chain. This starts creating a massive oxidative burden in the body, which starts driving off another cascade of stuff that we would seek probably see in the blood work again from like lipid values and so on. So with that glycine, it does a couple things. So the glycine is also the raw materials for the recovery side. Because of that oxidative burden, they probably don't look as, as good as they want anymore. Their skin isn't as good. Again, we mentioned the achy joints, the recovery from exercise. Well, the glycine is the raw materials for the collagen synthesis for the repair of these tissues. And then we would add NAC probably earlier in the day, just in case. Again, if I run their blood work, I'd know their homocysteine levels, which would tell me their, their methylation status. But if they're, you know, depending on their methylation station, nac, super simple compound, amazingly powerful. But before bed might be stimulating, depending on methylation status, but so just too complex. Take NAC earlier in the day. NAC with glycine together are all the compounds that create glutathione.
A
Yep.
B
And glutathione being this master antioxidant for that oxidative burden that we talked about. So this glycine before bed is super powerful for that. We mentioned the trt. It'd probably throw some bore on some other things. So you're talking just conceptually, I don't, I can't. This, this program is not a be all, fix all. It's for this avatar with a certain set. But this is what I'm talking about building that, that terrain like supplements are feeding into certain aspects. They're the raw materials and Some they're helping clear the signaling pathways with others and then we can. It's like what peptides are we using, when are we using them, what effect are we getting? And yet you can do things that are crazy. I mean this can be life changing. It is often life changing for folks like I, I had a client call last week with a gentleman. He actually tell a couple stories if we got time for it.
A
Yeah, for sure. I just wanted to say one thing which, which you touched on kind of you, you've done. You. You've touched around it. But the experience of injecting peptides is really jiggle and hide. If you have. If your gut can handle the immune response.
B
Yeah. So a lot of people, they'll take a peptide and they'll get some redness, some swelling. They might get a little shortness of breath. That is a histamine response. And a lot of people go I'm allergic to X peptide. And that is actually not the case.
A
Right.
B
That is, that is the, the body's. That. That's your engine or so you're driving your car.
A
Yeah.
B
And you step on the gas and it over. It overheats. Well the overheating wasn't stepping. You know that one instance of that. There's some issues that's going on with that vehicle that have put it on the edge. And it's that one extra thing that tips you over the balance. Like you stepping on the gas pedal there or sitting at a light was not the thing that caused the, you know, the radiator to boil over. They don't really do that anymore. I guess I'm showing my age. Right.
A
But
B
yeah, that used to be a common thing. There would always be like a car, you know.
A
But you know what? You didn't blow, you didn't blow a tire because you pressed on the pedal like super fast. You, it helped but you know, but
B
yeah, your, your alignment was off and you've been wearing on the inside of the tire. That's a good one. I think I'll switch to that one because the.
A
Go. Go for it.
B
There's a, there's a whole lot of factors that have led up to that that needed corrected. And this just put you over the edge. This is a histamine load. I've got article on my community if anybody wants to go. And I've got a video, I think two videos on this. So it's a great signal. It's great to know. So it's actually seeing that is great. And we could. So in that case like Typically you're not going to have that with those oral ones. But if we switch to that blend being the injectable, the same like repair mechanism. So BPC, GHK, TB500 we would maybe add KPV in that mix. That's a blend called klow. That KPV helps bring down that histamine response. It's still a little bit of like duct tape, right to that.
A
Yeah, yeah, yeah.
B
Some common ones. So like if you do have like immune or GI issues, stay away from the GH releasing peptides which I will talk about. So with this avatar I'm probably going to employ them but not right away because that can potentially make some. It's going to drive up immune response a little bit and those are typically the most common ones to create this histamine response. And so what do you want to do? It means you're probably starting too many peptides all at once. So back off and ease into it. Lower your dose, bring into it. But look at your overall histamine load and your histamine clearance factors which comes into again, diet and other factors again. I've got a whole free article and videos on this.
A
Of course it's going to be in the show note but how do people access your community?
B
If you just go to my website, enhanced executive, there's a little button at top that says community join that. It's on the school platform but it's absolutely free. I've got tons of articles and videos. My whole education system on movement principles is on there as well and I've got a set of that like all on the free side as well. That is, that's a program by the way, if people watching this video like I worked with nearly every sports team out there and thousand like essentially what is done in training and movement principles is a system that I developed and had. It basically influenced a lot of strength training and clinical practice today. If you look me up, you'll understand, you'll. You'll see that. So I've got that whole thing there. If somebody pays 29 bucks a month, you get access to all this. I've got 350 hours of lectures, 1800 videos, but I put a bunch of that for free on there as well. Just some basic stuff. Like my whole sleep course is on there right now. It's a six and a half hour course on sleep. It's free right now. So go join, walk through the sleep course. It is bomb. Yes. The intent of the course is not to put you asleep by watching six and a Half hours maybe.
A
But you can sleep to it and by morning you know everything you need to know, so. But Chris, I want to double click on something you said if that's okay.
B
Yeah, go for it. I feel like I've been on a rant for a while. I'm gonna back off for just finish this dude.
A
So I love it. So you mentioned the, you know, either clow which is with the KPV or GLOW stack which is like pre kpv.
B
Glow. Yes.
A
Yeah, yes. Something I, you know, in private conversations I voiced my opinion that if someone is not injection and habit averse, they might consider like breaking it down to the specific peptides. Because you're giving and taking something if you're using it as a compound. Right. You're nodding your head, so I'll let you finish that. But not all peptides like the same dosage and frequency, right?
B
Correct. So I reference those a lot because usually that's with people getting started to peptides and injection fatigue and adherence are the bigger issues than getting like this super optimal dosing.
A
Yeah.
B
And there is some negative information floating around that started by this guy that calls himself a Dr. Trevor B out there that kicked off this whole thing saying that those are completely bunk and they don't work because they don't compound together. And he dropped a bunch of fake, fake research to citations to justify his super just completely wrong.
A
I'm in skincare. I'm in skincare. 99 of the information out there has nothing to do with reality. They so yeah, yeah.
B
So and I validated, I put the I. I've reconstituted my fridge.
A
So awesome.
B
It's like, I'm like, you can talk about theory all you want. And I just like I let that go online for like a month while I had them sitting in my fridge, then sent them in. It was about 45 days or something at that point. And zero degradation. Like I'm like, I knew that what the results were going to be. I was around when these things were freaking cre, the blitz were created.
A
Yeah.
B
But I'm like anyway. But yes, TB500 can be taken like once a week. If we've got like a major injury, I'm going to want to load up the first few weeks and take a massive amount of TB500 because it actually kicks in a little bit slower. Bpc's half life is around 20 to 30 minutes. So we do that twice a day. GHK is a little short when it's injectable. Not so in cosmetics. Right. So those Half lives are different. The dosing is, is going to be different. But unless you're like really know that well and know what those are going to be, that's where the blends, they're, they're across the board kind of average of where those things would be. But I'm going to change that if I've got, if I've got somebody taking that blend, let's say the GLOW blend for example, and we are in a post injury situation. They're like, hey, I've got you know, three bottles of that. I'm like, we'll keep taking, go ahead and take that. We're going to go ahead and buy some TB separately. Boom. Now you're always with that it going to take this at the minimal half life. So that means because BPC has that short half life, that GLOW or Cloblend always needs to be delivered on a twice a day approach to have effects. And so, and then it makes it a little bit harder for the math if you want to get optimal dosage because it's like you'll get TB500 if you look it up. You'll get the dosing for like a weekly basis or twice a week basis. So you'll have to like take. What is your dose in that blend? Average. What am I getting for the week? Okay, so splitting those up if you want to really dial that in and if you're working with a practitioner, they're probably going to have those maybe in separate so that they can tell you very specifically this is the dose. Because hey, maybe we don't want to be on GHK for that length of time. Yeah, maybe we've got some low zinc levels that we're seeing in your blood work. So we don't want to push ghk, you know, but the minimal amount of time for example, because it does have
A
a depletion, because you're going to be, because you're going to off balance zinc and copper levels.
B
Yep. So there's reasons around that. So the, the, the most optimal approach is to not use it. But there for me, I go there and default there because it's dealing with the most biggest issues which is people just missing, you know, doing compounds going off protocol because of, of fatigue because they've got, you know, five injections that they're doing. So yeah, for sure. And math and easy. It's just like, oh, I gotta take this on Thursday and that one on Saturday and this one like, it's like, it's just, oh, you brush your taste before Morning and before bed, do your injection. Done. You don't have to think about anything, you don't have to plan anything. So I would agree with you, but also counter with the other.
A
So for sure. So let's say we talk about someone with like injection fatigue and glow cloblende. These are gonna be, you're recommending twice a day. However, what is the minimum that people can inject that I've seen like protocols that ask for like three times a week or something like that. Are you saying, hey, this is just not, don't do that, it's not effective?
B
I'm saying, so it's still effective, but if I drop it to once a day, it's going to be half as effective. Right, Got it. I can't up the dose during that period. There's only so much absorption. Now you can. The GHK, the TB500 is going to be, the TB500 is going to build a little bit. So it's not quite half as effective because some of the compounds are going to be half of as effective as soon as you do that.
A
Right.
B
But others aren't. So it's give or take. Like, hey, I don't need as much of the BPC effect. You know, this is super easy. I'm just going to take this once a day. So I'm going to get those other compounds. So yeah, I, you can do that. And I do have some clients do that as well. But usually I'm talking about an injury case scenario or hey, let's not. I, I'm a, I'm a big fan of giving things a break. Like your reception. Yeah, the research around these compounds, you can take them continuously. There's doctors that prescribe them continuously. I just don't agree with that though. That is fundamentally receptor biology. Human like physio like tells me we should not do that. But most people like 40, 45 plus they're, let's say the Globelin for example, or that combo, running a cycle of those, you know, for eight to 12 weeks, twice a year, it's gonna end up being beneficial. Like your skin's gonna be better, your joints are gonna be better. Maybe you can push exercise a little bit harder. Like, hey, if you're prepping for a marathon, tie it to the, to the, the training cycle leading into that, but during that you're gonna move backwards a little bit. And there's a lot of people that are in that 45, 50 plus that wanna run it a little more continuously because they're like, wow, I had A lot of damage, beat up. And so I'm like, hey, all right, do 12 weeks on, four to six weeks off. Okay, well if we're only getting half, like half the effectiveness for whatever period of time that we're doing, that's why I'm going, if you're going to do it, try to do it twice a day. But if that's a stalling point, don't stop. You're still getting additional benefits of the TB500. For example, by doing it once a day, you're still getting half that dose of bpc. So nothing with that. But you can't really like, I guess you could bump it. It's just like you're wasting extra of the bpc, so you could double up that dose and those other compounds, the, the anti inflammation. So let's talk just a second about what they do. My house analogy, like BPC is the, the foreman at the site. So we've got our substrate, our raw materials, like our glycine collagen coming in and it's going, all right, this is where the raw materials go, right? It's directing, it's the site forming. TB500 is more of the architect. And that architect showing up on the site also has an anti inflammatory effect. It's helping with. You guys are a mess. Get your stuff and go order this up. But it's the architect. It's creating the 3D blueprint for the foreman to follow. And I say that because it affects this protein called actin that makes up 20% of the cell and creates the structure. GHK CU is the master craftsman. And I call it that master craftsman because it's leaving it in better condition. It's the one that's doing that 98, that final bit that takes forever, that is putting the molding on, doing the countertops, like all that fine work. But it's, what it's doing is making sure the materials are laid down in the right area. So instead of the collagen blasting and it's just like, you know, all over the place. Yeah, it's, it's, you know, it's, it's got, it's got direction to it. It's, you know, aligned in the way that it needs to as it interacts with the fascia. Is it like. So it's the master craftsman. It does affect 4,000 different pathways and it does affect neurological. So typically, you know, if we've got some pain, sensitization pathways or let's say back pain that maybe have a neurological base into it as well, maybe some peripheral nerve sensitization. It has an effect on that. So there's some really interesting studies around that they did with TBIs. You know, it's animal studies, but the effect that it had neurologically in that is really, really fascinating. So GHK is that KPV is the firefighter. KPV is standing there with the blaster ready. If there's a little flame, you know, or some smoke smoldering somewhere to, you know, blow that out, it's insurance. It's making sure that oh my God, there's a little smoke. Everybody's running around crazy. We're not, they're not listening to the signals anymore. There's. If there's fire going on, it's helping. So it may or may not be doing anything. Now if we've got somebody with higher levels of inflammation or autoimmune type issues, things like that, we're definitely going to go with that cloblend. But there's also not anything bad that can happen from having the extra insurance too. At the same time, you know, obviously if we push anti inflammatory effects too high with multiple pathways, then we start dampening our body's adaptive response from like exercise and other things. Right. Because it's like inflammation is the driver of inflammation is good, the right kind of inflammation. Like it's the signal that creates the body to have some adaptation. It's chronic and sustained inflammation that is bad.
A
Yeah. And sometimes I say the problem is the exchange inflammation is absolutely never the problem. It's how well you resolve inflammation that is the, that is the issue.
B
It's how your body is responding to this.
A
Yes.
B
Just like immune, like people think like a strong immune system's good. Well, no, like an overreactive strong immune system. That's autoimmune disease. So it's ready to damp every. It's the right, it's like the right response. Just enough, fast enough being reactive, but also not over responding.
A
By the way, they now know that even acne is, is a, is significantly. There is significantly higher attribution denominator that goes to your immune response to acne bacteria than the actual bacteria.
B
Yes.
A
Yeah.
B
That's why I said when you start clearing this stuff up, like so many things like get better. Like you can see it in a, like. That's why I was going to give a couple case studies.
A
Yes.
B
So simple one. Last week I was talking to an attorney that has his own practice. A year ago he had a heart attack while he was training. Wife had to call the ambulance. They Took him in. Then he had another one shortly after that. And when he reached out to me, he was in bad shape. Like he was the sole provider for his family. His kids are getting ready to go to college and he's like, I can't even get through a day. I'm crashing. I can't train my, my, like cognitively. I'm not there. There's. There was problems, you know, relationship wise, you know, not being able to do things emotionally. Same thing. I mean his, like this was. He didn't know what to do. His life was falling apart in every direction. We had cognitive damage from the two heart attacks, right? We had, we. We had neurological issues. We had just a cascade of stuff. So similar is thing. We. There's a. I can't walk through that whole protocol. But I'm on the phone with him last week and he's just, you can just see like he was just full of energy and he's talking about all this. Last week I got my.
A
Wow.
B
My son moved from one apartment to another at his college. We're prepping the other one. We just had grad. We did two weeks and he's just going off and. And I'm like, dude, you like your energy just in this meeting, you couldn't even sustain one of those days. And. And he's. And then I hear in the background somebody. Is that Chris? Is that Chris? And he's like, yeah. His wife runs over, gets on the screen and she's like, I just want to thank you. And this is me. And I clarified this on the call, like for the, the life changing effect you've had on our entire family. Like, this is a game changer. Not clarified. That's him. He did all the work. I didn't do anything. I'm just a guide, like a mentor in like that plan. But when I'm talking about life change, I mean this guy was suicidal. When he got on the call with me. We had coaching sessions along those type of realms because that's where he was like physically, mentally, emotionally, everything was, was just absolutely destroyed. Having exercise taken from him because he couldn't sustain. Like, I mean he'd go out to. Try to go out to dinner and like have an issue. Like he couldn't, like he, I can't describe the shape that he was in. I was worried. I'm like, I don't. Like this can be a long road. I warned him of that. But we got there. Another case I had. So we've been talking a little bit about autoimmune I had a client, he was a. Not in this country, but one of the most famous actors in the world. And he's getting close to 40. He's been using steroids for 20 years. And he kicked off an autoimmune disease. He's trying to prep for this movie and they canceled the movie because he looks so bad. They're like, movies. This shoot's canceled until you get your stuff. And so he's trying to like, you know, train run his cycle and every couple weeks he's in the hospital for that. And he, by this time he's also got a staph infection that won't heal.
A
Wow.
B
So that's, that's what I get. I got referred by one of the top doctors in the country that he's, that he's in that, that knew me. And they're like, well. And honestly the reason I got referred was also because I do have an experience in anabolics. And they were literally like, we also need to know what anabolics he can take because let's just get him looking. Okay. Enough that they can film this last movie of his career. He can put that in his bill, then he can focus on health. And we didn't do that, by the way. So we dealt, we, we dealt with the things. Within six months, not only was the autoimmune in full remission, by the way, his back, he couldn't train, he couldn't lift heavy because his back was shot. So he was doing, you know, really basic rudimentary exercises. Within six months, auto, autoimmune in complete remission. Staph injection, you know, staff infection healed.
A
Wow.
B
He's squatting in deadlifting more weights than he's ever done in his life. In nine months, he's in the best shape of his life. There he is. He's already starting shooting the second and third movie since then. And they are planning a full fitness release because he's never looked so good. And shall I note, he's not on steroids.
A
Wow.
B
So that is why I've gotten from there. I got a lot of very high profile clients after that because people saw that, that knew in that community, you know, they're like, what happened to you? Who, where did you do so? But that wasn't a peptide. That was all the things that's, we were managing the exercise and the load progressions, we're managing the nutrition and the, the supplementation and ensuring lifestyle. Like it's all has to come together to pull that off. The right environment, the right substrates, the Right signaling, the right amplification and the right adaptation.
A
I love it. Chris, these are incredible stories. And you know, I think everyone, wherever they are, they can, they can literally like put themselves there and adapt their conditions and see how that's going to benefit them. Have you ever had people who. Their goal, their main goal, and I'm sure you have, their main goal was like this guy was to look their best. And when you're doing something like that, a lot of the, when we educate consumers, listeners, as far as the things that they want to do to their skin in order to look its best, we emphasize the, you know, I try to trademark, I, I tried to trademark prejuvenation and the U.S. patent office, you know, laughed me out of the, out of the building, the proverbial building. But the reason I wanted to do it is because I believe any, any type of, you know, procedure people are doing, they are obviously are going to respond to it. How they respond, it's on them to get the results. It's not the laser, it's not this microneedling or that. It's how they're going to respond to it. So when someone is living, doesn't have to be high profile. Everyone is high profile in their life, right? When someone is living with the main goal of presenting the best version of themselves visually every day, is there kind of a crescendo that you aim for as far as like the body's response when they're going through like rejuvenation procedures, etc.
B
What do you mean by crescendo?
A
Yeah, let me explain more. A lot of the times when people meet Yungus, it's when they are looking to go deeper and more profound in the way that their skin, you know, behaves day in, day out, right? They want to younger looking skin and normally it's a decision. It's exactly like the New Year's resolution, right. They want to do everything at the same time. It's kind of what we alluded to in the beginning.
B
Okay? Yes.
A
And normally we're telling them, hey, could you stop for a second? You need to use, you know, these two basic products like the ones that cover the whole 12 hallmarks of aging. And you need to use them at least for two months before you're going ahead and doing the, the, the thing, the stimulatory actions that are going to, you know, increase cellular turnover or increase collagen production. And all of that you are right now are going to over exhaust your mitochondrial. Everything that we talked about in the beginning. Mitochondrial function the demand on cellular repair, etc. You're just going to create it, create a fibrotic, less functional tissue and you're normally, by the way, there is a cascade after that that is even worse that they don't look as good. They think they should have done more, they're looking for, for the best thing, etc. Etc. So are you meeting something similar in your practice as well? Because I'm sure a lot of people come to you as a New Year's resolution type situation as well.
B
So I guess I was alluding to that upfront with like the scenarios I was walking through and going, hey, well we would start here and then after that we move to here. And if we were doing IGF with that example, maybe we'd start that over here. Yes, a hundred percent. You have to build to be prepared for the next phase and then the next phase. So we're actually typically projecting out 9 to 12 months conceptually. Like these are the focuses in general idea of what those plans are going to be. We can't really refine that until we discover where we actually get to at the close of this phase. Because what's adherence, what's the body's response? All of that. Like, what does the blood work show us so that now we can build upon that? Like there is. And that's why I said there's no, no, here's the protocol. Here's the best protocol for X, right? Because it's always where are we at now? What is the objective and where are we going from here? And, and preparing for that next phase. It's the same thing in an ex. Like, because this is physiology at the whole, like if we're training an athlete for an Olympic prep cycle, there's not, here's the fixed training cycle that runs from here to here. Like there, there's an accumulation phase, there's a realization phase. There is like this has been researched for so long in incredible depth in like the, the, that kind of physiology. But the same principles are at play and we have to do the exact same thing. So. Absolutely. Now I don't get people that are just solely interested in the cosmetic presentation, but it's, it's kind of still tiered. So like with our clients, we are generally looking also at the, so we look at three things. What is, what's the physical training, what's the cell, you know, what are we doing at a cellular level and what are we doing with the mind? Because you could try. I need to tackle all three, right, because yeah, you get the biohacker that wants to inject all the things and fix everything. Then it's like, yeah, we need to, we, you know, you, you, you, you, you, you can't, you can't biohack your way around these, you know, these base things. Like, but you also get like, maybe the person that just does is so set. Like, it's just hard training and I can train my way through this. And it's like, dude, we've got a hormonal problem.
A
People think. I also took a course that the guy said that I can sleep four hours a night, but if I do this, this and that, and if I take this supplement, then it's gonna be, it's gonna count as eight hours
B
exactly. And it's like, we can't biohack our way around like, poor loading, poor movement. Like, we can fix that shoulder, but you're gonna keep blowing that shoulder out over and over and over again until we fix that. That's the example or the mind. Why are you where you're at?
A
Right?
B
What you know or why can't. Why are you not able to achieve the, you know, what you think that you're possible of? So our coaching includes this whole pattern and without too much of a giant background. But my prior career was executive turns arounds and mentorships. For 20 years I was an athlete on the side, run these other businesses. Anyway, I've got 25 years, so I've got a three year curriculum on this executive mentorship component which is leading yourself, it's leading through others, it's leading through execution. Super in depth. Our celebrities aren't interested in that. So our celebrities are generally like, hey, I want to look good, you know, on camera for the movie. But that looking good also means feeling good. Because you can't look good without having the energy and the vibrance right. To, of feeling good to be able to present in that manner. So if you dig in, you will find like there's usually almost always these gaps, you know, in both. And so we're typically. I've never addressed cosmetics just alone because it's always that other aspect of it when it comes to looking good. And it's probably just related to the product and the coach type of coaching that we do because we're not in the, you know, the cosmetic side, although we do affect that.
A
Yeah. And I think also you mentioned the mental aspect and that's something it's very difficult for us to dedicate a lot of time for because it's a lot of legwork or Mind work, if you would. But one of the things that determine long skin longevity the most is the, the basically cortisol. It's like metalloproteases. You know, metalloproteases which are, which are affected by a raise of cortisol are the number one thing aside from UV that's going to break collagen down. And by the way, that's not even, not, not even skin specific. That's any, any, any elastic tissue in your body.
B
And that is why if anyone watches like my YouTube content or listens to this discussion, you'll hear the things around me hitting through on, hey, if it works for you, like the adhere, like the, the adherence, the fatigue, the, hey, calm down, don't worry about like my YouTube content. Like there's influencers spouting this, spouting that, like, hey, just chill out. You don't need to change everything. It's just that response of like, don't stress and don't freak over what you're doing because that is going to have such a negative impact. And that's where I'm trying to get people like, it has such a profound piece now. There's a lot to unwind there. As far as the mind side, again, we don't need to get into that. But I even, I teach a course at UC Berkeley once a quarter on applied human resilience. I've, you know, lectured at the, at the Capitol and many other places around things related to this. It's actually I also have a best selling autobiography that is in those category that was bestseller for psychology, personal development and stoicism, other stuff so kind of related to those topics. So anyway, I'm just speaking to that other piece of that curriculum that we're not diving into. There is a significant amount of depth in that.
A
So, you know, it's interesting because that's something I've tried to explain for a long time about, you know, we were the pioneers in skin longevity. And for a very, very, very long time I had to convince people that this is a paradigm they want to subscribe to. Right? Yep. Right now I need to explain to them that they are being sold an adjacent paradigm, but it's not a complete, complete picture. So I experienced it in the early 2010s with red light therapy when, you know, was an executive in a red light therapy company. You had to convince consumers it's real and later you had to convince them you're special. Right. So the person that I kind of stole the framework from is Dr. Jeffrey Gladden. He has a book called 100 is the New 30. And he said it really well. You know, the way I view longevity or whatever you want to call this are the three pillars. First pillar is what is optimal performance right now. It's a lot of what we talked about. The people that, the, that. The executive that. That got a heart attack, did everything that we talked about, the people that take people out and, and, you know, are drinking the alcohol. Alcohol and pushing themselves hard. There is. We don't want to take, you know, as far as skin is concerned. That's how the skin looks right now. But if you focused only on that, you are jeopardizing. So if you focus on one pillar more than the other ones, you're. You're putting the other ones at a. At a disadvantage. So the other, the second one, which you've, which you've raised is resilience. Resilience is probably the thing that is. That is the most overlooked in, I think in health in general, but skin health, definitely it applies to skin health as well. You know, if you had a poor night's sleep, if you, if you were exposed to a lot of pollution or if you, you know, are under a lot of stress, all of those, you know, I had a, I had a. I had a lecture about it. And my, the pictures on the screen, they were the emperor from the Star wars, but before and after and after. It looks disgusting. But if you look at any president, obviously you could see the difference in four to eight years. And the third one is slow aging, is longevity, health span. How well do you look later on? Do you think this is a paradigm that applies to the way you view the world as well, or do you view it a little bit differently? Are there things there that you. That you feel like there. Are there other verticals that you feel like have to be addressed?
B
I think that hits that pretty well. And for me, resilience is the big thing. Like, that's what I consider myself as, is a resilience coach. So I teach cellular resilience, physical resilience and mental resilience like that is underlying. And if you read my book, you'll understand why this is so powerful for me. But resilience is the thing that we have control over. We don't have control over time in the aging process as a whole. But our resilience is the best way to be able to withstand the things that are going to come at us in this world that we don't anticipate from, you know, some significant exposure event to resilience to Aging to resilience, to trauma, to result, like to some imposed demand or load. Like that is the most powerful thing that we have the ability to. And that ties back to one of those first sentences I said around specific adaptation to impose demand. That is how we can fundamentally have an impact on it. So everything for me is tools that I employ across the resilience on that. But the overall framework I would agree with that just is my personal focus within that.
A
Yeah, yeah, I love it. Chris, we're exhausting the time. It's such a wonderful conversation. Let me ask you something. We talked a lot about kind of your philosophy and how it applies. You know, we talked a lot about the fact that you've developed a philosophy for over 25 years that is now. The zeitgeist is kind of now drifting towards your view of the world. And I'm sure, again, kind of what I described before about being. Being a pioneer. I'm sure some of it is very satisfying and vindicating and very nice, but some of it, you feel like there's a drift from. From the truth. Again, people are, you know, when money is involved, the truth is being leveraged right within the longevity world. By the way I use the word longevity. Wellness could be used there, whatever you want the word to be. What do you feel like is the most misunderstood or overrated idea that's circulating right now? That is. Or something that is overhyped, that people are kind of really missing the point there.
B
So, yes, I feel grateful that the zeitgeist has moved to where, yeah, I've been for so long, because that is, yeah, it's a great place to be. But at the same time, I end up finding myself as the individual that is now kind of almost anti peptides as a result of that. Because I'm like, okay, there is the biggest issue is the fact that it's gotten so popular so fast and everybody is an expert and everybody thinks that they have been in it from the beginning because they've been in it for two years or so long because they literally think that that's how long it's been around. Like, I've filmed some content where I've talked about how long I've been in it. And they're like, well, you're just making stuff up. Like peptides weren't even around then. I'm like, shall we talk about the history of peptides starting back in 1926?
A
Oh my God.
B
So I've synthesized, they've been around forever.
A
It's crazy. I start to see Trends looping themselves in skin health. Well, that's the crazy part.
B
So that is exactly what I'm seeing. So when I mentioned that Dr. Trevor B. Thing earlier, doesn't really matter who he is, but here's where the overhype cycle happens, everybody. So in social media, they want to be sharing something new and crazy to demonstrate their expertise, authority, and more importantly, draw views so someone will come out and say something. And in this case, this one person just, they have AI generate these scripts and do the research for them. And it's hilarious because this, the, the research they're citing is just made up. If you know anything, you're like, those are all just made up studies. But he's just so authoritative, just boom, boom, boom, this is the way it is. And then you will see another person pick it up and then another. And then all of a sudden there's this whole cycle and of this parroting and that's all people are doing. That's the problem with the, how fast it's gotten is people don't have the depth of knowledge and they just parrot this stuff. And you have so many experts and so many people trying to make a buck. And yeah, I'm, I'm making a buck in this. This is, this is what I do for a living. But there's, there is no. So I'm, I'm, I'm the guy that's been, you know, on the research Peptide front, like, so I have access to the tools that aren't necessarily fda, you know, approved yet that we need in unique situations. My whole business is based on clinical referrals because of those tools, because I have them available through that network. Yeah, but I'm now like, there needs to be some controls. There needs to be some things in place because of how much this has grown. This isn't early 2000s and I'm on some unique forum talking to the people that are literally in the lab doing the research on this stuff that are publishing the papers, because that's how that operates. Like, that's not the place anymore. It's some girl I went to high school with, that's a hairdresser that's Learned about peptide 6 months ago, pimping codes and talking about this is what NAT plus does. I'm like, that is crazy.
A
Shout out to Christy the hairdresser. I'm kidding.
B
Nothing against, but that's where we're at right now. And that is dangerous. So I've become, I'm a research Peptide person that thinks that, hey, we need to be Going route of, of tightening some controls. I'm the peptide guy going, wait, hold, don't do some peptides. Let's talk about these other things first. So yeah, I'm literally like anti all the things that I literally do for a living. Like that's what it is created from out of this for me. But yeah, the, the loop cycles are just crazy because it's just parroting, it's just parody. And you'll have these major platforms that are followed by people that are, you can tell, just parroting the same language again over and over and over again. Like, I don't know. And you're also my glow and cloth video. Like the people I put in that have millions of followers as peptide experts just espousing completely, completely false information.
A
Well, I think I told you in one of our conversations that we are, you know, we are trying very hard to introduce good research into skincare. And I had a conversation with the guy that owns a patent for Motsi, by the way. He says he literally is like, hey, I don't even know who to sue. Like who am I? Who am I going to sue? But he's like, you know, I got to tell you, any publication we had was a two a day injection. I don't even know where the current cycle is, what it's based on. I have no idea. I'm looking at the cycle. I'm like, what mechanism are you rationalizing that through? But yeah, I'm just one. When another looping is like the things that we see when the community is small, you see them kind of becoming hyped up and I, and I now see them. I'll give you an example. So you know, pdrn Salmon sperm DNA is now like super popular as an injectable for, for the skin. It was, it was an ingredient that, that companies were trying to push into skincare in the 90s.
B
Oh my God. Yet these bigger loop cycles are hilarious where people are coming out and they're like, oh my God, this thing, this whole new supplement is being released again. It's like, we went through this in the 90s. We went through this again. The 2000 and tens. They're like, have you heard of this? And I'm like, yeah,
A
I wonder when we're going to hear again that AOD 9604 can replace STEM cells when injected into a joint. Because of this one rabbit study, I believe it's probably 12 months away from us hearing about that again. And that's going to complete the peptide loop and we can start Over. Anyway, listen, Chris, we're gonna have to do it again. We've scratched the surface.
B
I think it was a really fun conversation. Thanks for letting me just spout off on things.
A
This is my favorite conversations. Listen, normally it's me and I really appreciate when it's someone else. So I super appreciate you. Everything is going to be in the show notes. We are going to prepare kind of a little downloadable field notes of this interview as well because it was full of great information and you did talk about your school community. Where else is it best to kind of follow you or see what you're doing and then how can people work with you directly?
B
Yeah, it's pretty easy because I'm actually really easy to find. You just type Chris Duffin. That's like Muffin but with a D, D, U, F, F, I, N. You can do Google. You can do whichever social media account I'll come up. And typically the handle is Mad Scientist Duffin. You can guess why. And you'll. You'll find me. If you go to chrisduffin.com it'll redirect you to the new site, which is Enhanced Executive. Just because we've gotten very kind of focused on our coaching, because we can. And so you can find me there. We do consults, full coaching, and have peptide supplements and the regenerative modalities on there as well. So Red Light partners. Our own pimp mat. Yeah, just all the stuff. Free ebook or not? No, the ebooks do cost you. I think they're like 10 or 20 bucks. But if you join the community, I think you get some of those just for free. So our community is kind of like the main point. I am on social media posting on occasion, but I'm really not there anymore. So I'm focusing pretty much on the YouTube and so if you want to chat with me, go to the community. I drop in there and answer questions two, three, four times a week. And yeah, reach out. Schedule a call or not. I'll get.
A
All right. Thank you so much, Chris. This was incredible and we are definitely going to bug you to come on again.
B
I love it, man. I love it.
A
Thank you,
B
Sam.
Release Date: July 15, 2026
Host: Amitay Eshel
Guest: Chris Duffin
This episode challenges the current hype around peptides and their place in longevity, skin health, and regenerative medicine. Host Amitay Eshel and guest Chris Duffin—a systems thinker, engineer, and world-record powerlifter with decades of peptide experience—break down why focusing solely on peptides or “signals” is often a red herring. The real variable: the underlying biological “terrain”—cellular health, environment, sleep, and resilience. The conversation offers a systems-level paradigm for actual results, moving beyond fads and protocol parroting toward intelligent biological recalibration.
“The most expensive peptide in the world will do absolutely nothing for your skin if the cell underneath is dysfunctional.” – Amitay Eshel [00:05]
“They're a signaling molecule. ...If you've got a house that's, you know, been demolished in a storm, all we can do is send signals to the job site... you’re just burning money, wasting time.” – Chris Duffin [04:15]
“Why in the world are you trying to jump on, like, Retitrutide and the Motsi ... and it's like, you're not even exercising regularly. Like, that is the number one biohack in the world, is to push against resilience.” – Chris Duffin [04:16]
“A poorly built house and an incredibly built house can look identical... but one falls apart at 40, the other thrives into old age.” – Amitay Eshel [08:53]
“TRT just forces the system to behave as it should behave, and it ignores everything that happens before.” – Amitay Eshel [16:03]
“You have to build to be prepared for the next phase and then the next phase. ...Typically projecting out 9 to 12 months conceptually...” – Chris Duffin [50:19]
“That is a histamine response... There’s a whole lot of factors that have led up to that that needed corrected. And this just put you over the edge.” – Chris Duffin [27:12]
“The most optimal approach is to not use [blends exclusively]... but for fatigue and adherence, blends are the practical choice for most people.” – Chris Duffin [34:28]
“Inflammation is absolutely never the problem. It’s how well you resolve inflammation that is the issue.” – Amitay Eshel [41:06]
On peptide hype and protocol parroting
“Everybody is an expert and everybody thinks that they have been in it from the beginning because they’ve been in it for two years... Peptides weren’t even around then. I’m like, shall we talk about the history of peptides starting back in 1926?”
– Chris Duffin [62:13]
On social media cycles and pseudo-experts
“In social media, they want to be sharing something new and crazy to demonstrate their expertise... There are so many experts and so many people trying to make a buck.”
– Chris Duffin [64:34]
On overall philosophy
“Resilience is the thing that we have control over. We don’t have control over time in the aging process... Resilience is the best way to be able to withstand the things that are going to come at us.”
– Chris Duffin [58:58]
Case Study Highlight
“When I’m talking about life change... this guy was suicidal when he got on the call with me... Now he and his family completely turned things around. That’s him. He did all the work. I didn’t do anything. I’m just a guide, like a mentor in that plan.”
– Chris Duffin [43:19]
On skin health protocols
“Any type of procedure people are doing, they are obviously going to respond to it. How they respond, it's on them to get the results. It's not the laser, it's not this microneedling or that. It's how they're going to respond to it.”
– Amitay Eshel [47:16]
“If you just go to my website, Enhanced Executive... my whole sleep course is on there right now. It’s free.” [29:11 & 30:22]
This episode challenges the single-molecule obsession dominating anti-aging and biohacking—advocating instead for a functional, resilient system as the only route to true optimization. Peptides are not the beginning; they are the finishing touch on a foundation of health.