← Biohacking Beauty: The Anti-Aging Skincare Podcast
Biohacking Beauty: The Anti-Aging Skincare Podcast
Exosomes 101: The Truth About Cellular Messaging in Skincare - Part 1
00:22:23
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- [00:08]
A
Hi everyone, this is Biohacking Beauty. Welcome. My name is Anastasia Khuja.
- [00:13]
B
And I'm Amitay Eshel. And we are the co founders of Young Goose Skincare, the world's first biohacking skincare brand.
- [00:23]
A
And today, today we have listened to your suggestions and questions and this podcast is for everyone that have been reaching out about exosomes. Yeah, so this is really exosomes 101. We've gotten a lot of questions about them and we'll just do a deep dive.
- [00:42]
B
I feel like everyone is talking about exosomes lately, but most people have no idea what they are, actually.
- [00:52]
A
Yeah, and funny enough, they're not ingredients, they're messages. Tiny packages your cells used to tell each other how to repair calm inflammation and build new collagen.
- [01:04]
B
And you know, here's the catch. Not all exosomes speak the same language.
- [01:11]
A
Yes, interestingly enough, there are plant based exosomes. So some come from plants, some come from stem cells, and one kind, platelet derived, communicates directly with your skin's biology.
- [01:25]
B
Today we'll decode which ones truly rejuvenate and why the source changes everything. So what exactly are exosomes? Think of every cell in your body as having its own messaging app. Instead of text or emojis, it sends microscopic bubbles filled with information. Those are exosomes.
- [01:51]
A
They're like tiny delivery capsules carrying proteins, lipids and microrna. So not mRNA. Very important. Very different. Inside that package are instructions your cells use to coordinate repair, energy and regeneration.
- [02:07]
B
When we're young, those messages move fast and clear. They tell the skin, produce collagen, keep inflammation down, repair damage quickly. That's why everything looks firm and fresh.
- [02:22]
A
But as we age, the signal weakens, the conversations between cells slow down and it shows less elasticity, slower healing, duller tone. All of those signs of aging. We kind of know very well exactly.
- [02:37]
B
What modern regenerative science discovered. Is that what we can support that communication again? Exosomes can act like push notifications to the skin, reminding it how to function in a youthful way.
- [02:52]
A
And they don't replace your cells or force new tissue. They teach your own cells how to restore balance. That's what makes them so interesting. They're intelligent messengers, not aggressive ingredients.
- [03:07]
B
That's also why exosomes aren't just another serum or product. They're part of a whole new category of skin care, which is cellular signaling.
- [03:18]
A
I love that. Yeah, that's so true. And the idea came from regenerative medicine. Doctors noticed that when platelet rich plasma PRP Was used for healing or hair restoration. It wasn't just the plasma doing the work. The secret was in the exosomes inside it carrying the repair instructions. And this is why we keep saying that they're carrying messengers. Messages. And they're messengers.
- [03:47]
B
Yeah. Very similar to the way when you inject stem cells into the body, Whether it's to a joint or wherever you would inject it to induce local healing, what we see is reverberating effect all throughout the body. It's not because the stem cells kind of, you know, travel around the body, Although they do. The main effect is actually the exosomes that come with those stem cells. Once that discovery happened, the beauty industry really jumped in. Everyone wanted exosome skincare. But here's what. Where things get messy, not all exosomes are the same.
- [04:24]
A
Yes. And that's because exosomes take on the personality of the cell they come from. If you collect them from plant cells, they'll deliver antioxidant and hydration signals. Helpful, but not the cutting edge regenerative medicine you know you're looking for.
- [04:42]
B
Yeah. Even if they come from stem cells, they can carry growth factors and repair proteins. But the source, donor and culture conditions change the outcome every time. It's like baking a cake with. With a different recipe for every batch. By the way, they're also designed to kind of to relay messages that are related to that organ, Whether it is, you know.
- [05:09]
Fat or whether it is umbilical cord. They relay very general messaging. And when you use them in skincare, it's not a one to one match.
- [05:20]
A
Yeah. And then there are platelet derived exosomes, the ones found in prp. They naturally contain wound healing and tissue repair messages that your skin already recognize.
- [05:33]
B
That's what makes them so powerful for both medical treatments and daily skin care. They speak the same biological language as your own repair system.
- [05:46]
A
And it's like your skin getting a voice memo from itself. Just younger.
- [05:51]
B
Exactly. That's why at Yungoos, for example, we focus on exosomes that mirror the body's own communication system, Instead of chasing exotic sources that sound trendy but don't perform.
- [06:06]
A
Yeah. The future of skincare isn't about adding more ingredients. It's about restoring conversation between your cells. And really, at Yungoos, we've always been about making yourselves your skin cells functionally younger. And this is really the. The top technology for that.
- [06:27]
B
Yeah. And once that connection is rebuilt, your skin knows what to what. You know what it what to do. You just have to give it maybe like the right message or nudge it in the right way.
- [06:42]
I want to take a moment to tell you about something we've been working on for for years here at Yungoos. Our newest innovation, vampire exosomes. You've probably heard us talk before about how most skincare focuses on surface fixes. A cream here, a peel there, while ignoring what's actually happening inside your cells. Vampire exosomes are different. They are PRP derived exosomes, meaning they come directly from platelets, the body's natural repair system. Each exosome carries micrornas and growth factors that tell your skin to repair, renew and reorganize collagen. Basically, it's how your cells communicate healing directly to your tissues. What makes this launch so special is that we finally have quantified potency. Each 30 milliliter bottle contains 3 trillion exosomes, or 25 billion exosomes per drop. And every batch is third party tested for both exosome count and micro RNA profile. That's true transparency. You know exactly what you're getting and that it's active, stable and real. The formula is shelf stable, gentle and designed to protect the exosomes. We've even paired it with Rejuve nad, a cosmetic active that boosts the skin's NAD economy, the molecule your cells use for energy, so the exosomes can actually do their job once they've been delivered. The results have been incredible. Early human imaging shows visible improvements in tone, redness and fine lines within weeks. Not because we're forcing change, but because we're giving your skin the right signals for repair itself. If you want to experience it, go to younggoose.com and use the code podcast10 for 10% off your first order. That's yungoose.com code podcast10. The link and the details are also in the show notes. And now let's get back to the episode.
- [09:16]
We've said not all exosomes speak the same language, so let's break down the three you'll hear about most plant, stem cell and platelet.
- [09:27]
A
I love that. And it's definitely one of the most common questions we were being asked.
- [09:33]
B
Maybe also we asked it, but.
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Anyway.
- [09:37]
A
So starting with plant exosomes, brands love to use them because they're stable, easy to source, and technically natural. But the truth is plant exosomes were designed by plants for plants. I always say, say, and I said it in our previous episode about vampire exosomes. It's like when you're speaking to someone that speaks a different language. A lot of the times you can get to some understanding between you and the other person. But it's never going to be as efficient, as direct, as seamless as, you know, really perfect as if you were speaking the same language. And that's why it really makes a huge difference.
- [10:18]
B
Yeah, plants use them, you know, to survive drought, sun, stress of some sort, you know, whatever that is, deficiency of nutrients just to help, you know, heal from different things that happen. Pests, for example. That's great for the plant kingdom. But our skin doesn't know what to do with those messages. Exactly, exactly.
- [10:43]
A
They deliver nice surface that benefits. So things like you were mentioning, hydration, antioxidants, a temporary glow. But they don't contain the growth and repair signals that human skin recognizes. Think of them as a postcard written in another language. Again, pretty. But you might misunderstand it or misinterpret it.
- [11:06]
B
And you like the photo on the backside? You can like the photo on the backside. Yeah, yeah. Well, what we see, I think what we see most in the regenerative space are what we call MSC exosomes or mesenchymal stem cell exosomes. These are human derived, they come from mesenchymal stem cells. These are closer to our biology and they can deliver impressive repair signals.
- [11:35]
A
Yeah. And a lot of companies on the market that might be offering mesenchymal stem cells and a different variation of the same product with plant stem cells. And that's because, you know, there are some regions that you can't ship the mesenchymal stem cells. And then again, there are some people that they just feel better with the word vegan. You know, if, if something is vegan that's better for them than, I guess, effective. But the challenge with the mesenchymal stem cells, for example, is consistency. Every donor, every cell culture, every lab produces slightly different exosomes. One batch might be rich in collagen, building proteins, the next could be totally different.
- [12:21]
B
First of all, to, to, to your point, I think it's important to kind of understand that skincare goes. Energy flows, whatever it's called. Like, like skincare goes normally where focus goes. Energy flows, where focus go. Exactly. So the focus right now is on the word exosomes. So I think it's, it would be the most insincere just to say exosomes and not have any exosomes. But most companies, what they do is they are saying, you know, we have ex. Sometimes they just say we have exosomes. But sometimes they want to say the amount of exosomes that they have there. So we have, you know, X amount of exosomes. Obviously plant exosomes are significantly less expensive than everything else. So in order to have a formula with a lot of exosomes, what they're going to do is they're going to have a kind of a blend of some human derived, normally mesenchymal stem cells, stem cells and plant exosomes. And they're going to say, you know, they might even emphasize the fact that they have the human derived exosomes. But when they talk about the number, they're going to talk about the general number again. Of course there is an issue with what you're getting at the end of the day as far as like the results. But you're also getting.
- [13:32]
Very inconsistencies, as you said before, like between your, your donors, what you can actually get. It's like baking cookies without a recipe, you know, without a recipe. Sometimes they come from, they come out perfect, sometimes they're flat and burnt. You really never know. Yeah, it's, there are so many variables. And again, as you said, it's not exosomes are just the, the out, the outer layer. It's what's inside that matters.
- [14:01]
A
And I also think that mesenchymal stem cells, there are a little bit a technology and a breakthrough of the past. As you know, as science progresses, new data comes in and maybe 10 years ago they were the best that the science had to offer and, but now that's where platelet derived exosomes really changed the game. Platelets are your body's first responders. Whenever there is an injury, they rush to the side and release these tiny vesicles loaded with growth factors, cytokines and regenerative micrornas.
- [14:37]
B
Yeah. Those messages literally tell your cells, close the wound, build collagen, elastin, hyaluronic acid, calm inflammation, take out the trash, remove senescent cells, make sure the function is youthful. That's the exact communication your body already uses to heal itself.
- [15:02]
A
Yes. Which means your skin instantly understands it. There is no translation needed, no confusion, no waiting for your system to figure it out. And it really is the most efficient technology.
- [15:15]
B
Yeah. That's why ex plant platelet exosomes have shown results not only in clinical treatments, but also when applied topically on intact skin.
- [15:27]
A
Yeah, which is huge. They follow the same four phases of the body's repair cycle. Homeostasis, inflammation, proliferation, and remodeling. It's like handing your skin a step by step recovery plan that is already like, is convenient for your skin. This Is the plan that your skin kind of trusts.
- [15:49]
B
Yeah. Meantime, plant. And also, sometimes you also see bacterial exosomes are missing those healing instructions entirely. And with stem cell sources, you just don't know what mix of instructions you're getting.
- [16:05]
A
Yeah. And I think it's an important factor that we keep, you know, bringing up. So platelet exosomes end up being the perfect intersection. They're biocompatible, consistent and potent.
- [16:18]
B
Plus when they're purified correctly, you get an incredible clean signal. No cell debris, no residual DNA or rna, no inflammatory noise, just pure communication.
- [16:32]
A
Yes. And it's so important that you mentioned that there is no residual DNA. I understand that there are a lot of concerns out there, but yeah, there is absolutely no DNA left in the sample. So when we're talking about platelet derived exosome, which is why what we chose for the vampire exosome serum, we use quantified platelet derived exosomes, 3 trillion of them per bottle. So every pump gives the same reliable signal every single time.
- [17:08]
B
The idea isn't to copy the PRP facial, it's to take the part that actually does the work in a PRP facial or in a vampire facial, which is the exosomes, and make it something that you can safely apply or use every day.
- [17:26]
A
Yeah. So instead of more of an invasive treatment once a year, it becomes a steady conversation your skin has daily with itself. And I also want to distinguish here that if you love your PRP facials, you can definitely continue getting them and this will support it and you will see that you get results faster and better. But those of you more on a budget, that is a more budget friendly option to use it daily and get consistent results versus periodical PRP facials. Because PRP facials, if you want to get results, you have to do them periodically, ideally every two to three months. Maybe for those of you who can afford to do it more frequent, even that is advised. So.
- [18:16]
B
Yeah, but it's, it's a, an over $10,000 a year budget to do those.
- [18:22]
A
Exactly. So in that sense it is a more budget friendly option.
- [18:27]
B
Yeah. And I think that's the beauty of biohacking. What we used to call, when we had the consultancy and the name, the name biohacking didn't really exist yet. We used to call it consumer facing medical technologies. And really what we're doing here is we're taking something that works in a clinical setting, but it is adjusted to be able to provide the same signals to your body at home without the need of a professional Basically administering that, I think it's biohacking through communication rather than aggression. Instead of something that your body can, you know, that your budget wise and just how your body responds, it's something that you can only do once every 1, 2, 3, 3 months. And so you're really giving the body a huge push and then having it recover for that amount of time. This is something that again is non aggressive, doesn't disrupt the homeostasis in the skin. So it's something you can do on a daily basis and communicate, repair, youthful function, etc on a daily basis.
- [19:36]
A
Yeah. And I hope if you have a takeaway from this podcast is that now when you hear plant exosomes or stem cell exosomes, you ask a question of like what kind of signals are inside.
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B
Yeah. Because if the signal doesn't match your biology, it can't unlock regeneration.
- [19:56]
A
Yeah. And if it does match, like platelet derived exosomes. Like platelet derived exosomes do, you're not just applying a product, you're activating your skin's own intelligence.
- [20:08]
B
So we basically talked about where exosomes come from and the difference kind of between the different ones. What we're going to talk about.
- [20:20]
In the next episode is what's actually inside of them and how much of it you're really getting. But I think what we did today with this kind of Exosomes 101 is definitely a good start.
- [20:35]
A
Yes. And we've been getting feedback that about 20 to 30 minute podcast is a better fit for you guys. So I hope you like that new format we're adopting now before we wrap up, I do want to read a listener review. Especially now we are giving away Blue Peptide spray. You know, each time we read someone's review and we choose them, so.
- [20:56]
B
So you better be nice.
- [20:59]
A
So this is the one that we're choosing today. It's by Liz Espinel. So Liz, please either email Service to get Serviceangoos.com to get your shipping information, we'll send you a Blue Peptide spray or you can DM us on Instagram. So here's what Liz wrote. I love this podcast. I have developed a recent obsession to skincare. With the overwhelming amount of products and information out there, it's hard to really understand which products are actually going to make a difference for you. This podcast does a great job educating you about what is scientifically proven to help and what is just a social media trend. They also speak in a way that makes it so easy to uncover. Keep up the great work. So thank you so much Liz.
- [21:47]
B
Thank you, Liz. If you like what we're doing here and you would like to try Yungoos products, head over to yungoos.com and use the code podcast10 to get 10% off your first order. Bye, everyone.
- [22:01]
A
Thank you. Bye.