Episode Overview

Podcast: Biohacking Beauty: The Anti-Aging Skincare Podcast
Episode Title: Exosomes 101: The Truth About Cellular Messaging in Skincare – Part 2
Hosts: Amitay Eshel (A) and Anastasia Khoja (B), Co-founders of Young Goose Skincare
Date: December 17, 2025

This episode is a continuation of the deep dive into exosomes—a cutting-edge topic in regenerative skincare. Amitay and Anastasia address common myths, clarify scientific details, and explain how exosomes and NAD work together to rejuvenate skin from within. They spotlight their own product, Vampire Exosomes, emphasizing transparent dosing, scientific verification, and novel ingredient synergy.

Key Discussion Points & Insights

1. Exosomes in Skincare: Potency & Transparency

• Exosome Quantity Matters

  • Many brands use the term "exosomes" loosely without specifying dose or activity.
    • B [01:00]: "Some brands just sprinkle the word on a packaging, but never say how many exosomes are actually in the... bottle."
  • Young Goose’s Vampire Exosomes: 3 trillion verified platelet-derived exosomes per 30ml bottle (approx. 100 billion/mL; 50 billion/application).
    • A [02:22]: "It breaks down to about 100 billion exosomes per milliliter. Or roughly 50 billion per... application."

• Third-Party Testing and Full Ingredient Transparency

  • Each batch is independently tested for count, purity, and even microRNA (miRNA) profile. Details and lab analyses are published on their website.
  • B [02:58]: "Our sequencing shows about 43% of what's inside those exosomes is Microrna. The tiny regulators that tell cells how to make collagen, calm inflammation and renew the skin's structure."
  • B [04:13]: "We've created a QR code for every batch. You can scan your own bottle and see the exact exosome count and the microRNA fingerprint of your exact product."
  • A [04:29]: "That level of proof doesn't exist anywhere else in skincare. Most brands still use vague phrases like 'exosome technology'..."

• Why Dose & Consistency are Critical

  • Without a biologically active dose, exosomes will not yield real results.
    • B [05:28]: "If a serum only contains a few billion exosomes in the whole bottle, the skin might not even notice. Sometimes, you know, the exosomes are just kind of like purely used for branding."

2. Exosomes as Cellular Messengers

• Role of miRNA and Verified Potency
  • miRNAs act as software updates for cells, guiding older cells to behave like younger ones.
    • A [03:55]: "You can think of miRNAs as the software update for your skin... guiding older cells to behave like younger ones."
• Transparency, Consistency, and Potency
  • The three pillars that set their product apart from the industry standard.
    • A [06:30]: "First, it's transparency, it's consistency, and it's potency that's backed by real lab data."
    • B [06:48]: "In other words, it's not just marketing science, it's measurable science."

3. The Essential Role of NAD in Skin Regeneration

• What is NAD and Why Pair with Exosomes?

  • NAD (Nicotinamide adenine dinucleotide) is a vital molecule for cellular energy and repair.
    • B [07:27]: "NAD is a coenzyme foundation found in every cell... your skin's fuel for repair."
  • Distinction: The product doesn't use NAD precursors, but rather stimulates natural NAD production with a proprietary sunflower sprout extract (RejuveNAD), promoting the skin's own NAD recycling enzyme (NAMPT).
    • B [08:49]: "NAD controls hundreds of cellular reactions... DNA repair, collagen production, antioxidant defense, and even how quickly your skin recovers after stress."
    • A [10:05]: "...we pair our platelet derived exosomes with... a proprietary sunflower sprout extract proven to activate NAMPT."

• Synergy: Messaging Meets Energy

  • Metaphor: Exosomes = text message, NAD = phone battery. Without energy, the message won’t be acted upon.
    • A [08:16]: "Think of exosomes as text messages and NAD as the battery on your phone. You can have the clearest message, but if your phone’s dead, nothing happens."
  • As NAD declines with age, the skin's response to exosomes weakens. By the 60s, NAD drops by half or more compared to the 20s-30s.
    • A [09:05]: "The problem is NAD levels drop dramatically as we age. By the time you're 60, you have half of what you had when you were 30..."

4. Scientific Results, Anecdotes, and Unique Claims

• Senescent/Zombie Cell Clearance

  • Platelet-derived exosomes may remove up to 40% of senescent cells in the application area, based on studies.
    • A [11:06]: "This is also a kind of unique feature of platelet derived exosomes... one study showed that it can clear up to 40% of the zombie senescent cells..."

• Personal Anecdote: Melasma Improvement

  • Anastasia shares how Amitay’s melasma dramatically improved after regular use of Vampire Exosomes.
    • B [14:14]: "It really is mind blowing that his melasma lightened... it's really pretty crazy how much his skin, like the melasma got lightened."

5. Practical Takeaways

• Combining Exosomes & NAD for True Biohacking

  • "Higher NAD doesn't just enhance exosome results, it multiplies them." (B [15:29])
  • The symbiotic effect: messaging + energy = ongoing, natural regeneration and youthful resilience.
    • A [15:41]: "That's the... real definition of biohacking your skin, combining the messenger and the fuel so your biology can do the rest."
    • A [16:02]: "Exosomes are messengers. NAD is the fuel... together they let your skin perform the way it was designed."

• The Future: Smarter, Not Harsher

  • The industry is shifting from harsh interventions to smarter, biology-friendly approaches.
    • A [17:27]: "I think this is really... the future of skincare. It's smarter, it's not harsher..."

Notable Quotes & Memorable Moments

• "It's the difference between whispering to your skin once a week or having a full conversation every single day." – B [01:25]
• "It's like charging the battery while delivering the message. The exosomes tell the skin what to do, and the NAD gives it the power to do it." – B [10:33]
• "When communication and energy meet, rejuvenation becomes effortless and sustainable." – B [15:51]
• "Try it for yourself. Apply this baby on your skin and see what happens when your biology finally just works with you." – B [17:14]
• "[Exosomes] are the messengers. NAD is the fuel... together they let your skin perform the way it was designed to perform." – A [16:02]

Timestamps for Key Segments

| Time | Topic / Quote | |---------------|------------------------------------------------------------| | 00:13–01:41 | Intro, Exosome dose matters, industry issues with vagueness| | 02:04–03:55 | Dose verification, 3rd party testing, microRNA profile | | 04:13–05:28 | QR code for transparency, inconsistent industry claims | | 06:30–06:53 | Three pillars: Transparency, Consistency, Potency | | 07:17–10:33 | NAD background, difference from precursors, RejuveNAD | | 11:06 | Senescent cell clearance and study mention | | 14:14–15:17 | Melasma anecdote | | 15:29–16:19 | NAD-Exosome synergy, real biohacking | | 17:27 | Smarter, not harsher: the future of skincare |

Listener Engagement

• The hosts encourage listeners to visit their site, check the FAQ, and scan QR codes for batch-specific data.
• They read a winning listener review from "Tahoe1984," reinforcing community connection and trust in the product. [19:10]
• Repeated calls to like, share, subscribe, and review to spread science-based skin health knowledge.

Conclusion: Why This Episode Stands Out

This episode demystifies the hype around exosomes in skincare, showcasing the necessity of verified dosing, transparent ingredient reporting, and the overlooked role of NAD. By combining real science with relatable analogies and personal stories, the hosts position "intelligent skincare" as the leading edge of anti-aging. The actionable insights, memorable metaphors, and uncompromising transparency offer something valuable for both the curious consumer and the science-minded practitioner.