← Biohacking Beauty: The Anti-Aging Skincare Podcast
Biohacking Beauty: The Anti-Aging Skincare Podcast
Jamie McGuire: Leaky Skin Debunked: What’s Really Happening
00:23:25
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- [00:07]
Jamie McGuire
Have you ever wondered why some people seem to have effortlessly glowing healthy skin while others struggle no matter what they try? In this episode of Biohacking Beauty, I'm sitting down with Jamie McGuire, a skincare consultant with over 15 years of experience and a true expert in personalized long term skin health. Jamie and I dive deep into the science of repairing your skin barrier, why nad is such a breakthrough ingredient for cellular repair, and how external factors like inflammation and environmental stressors could be silently sabotaging your skin. We also get into what leaky skin really means. It's not what you think. And the surprise, surprising way you can restore balance and vitality to your skin. Jamie's knowledge and passion for creating customized skincare regimens makes her the perfect person to help unpack these topics. So whether you're a skincare minimalist or someone who loves a multi step, expansive routine, you're going to learn actionable tips to elevate your results.
- [01:16]
Amitay
So let's get started. Foreign.
- [01:25]
Unknown Host
Thought I would just get in here a little bit early a couple minutes before we get started with Amate, the founder of Young Goose. So Amitay has come on with me before on the live and he's a wealth of knowledge and I really wanted to dive in more about the Young Goose line because I get so many questions about it. So this is a great opportunity for anybody to ask some questions. I already have some of your questions that I know are commonly asked, so I will be asking those questions also. And then we're going to go into like some favorites and some benefits and I just think will be really helpful for people. Hello, Amitay.
- [02:07]
Amitay
Hello.
- [02:08]
Unknown Host
Good to see you.
- [02:09]
Amitay
You know, awesome seeing you.
- [02:11]
Unknown Host
And how was your Thanksgiving?
- [02:13]
Amitay
It was very good. We obviously, we are immigrants. We actually don't have family in the United States. We get invited to this wonderful family and it was a blast. Yeah, First Thanksgiving for baby Lev. So that was fun.
- [02:27]
Unknown Host
I know that must have been really cute. And now first Christmas coming up, which is exciting too.
- [02:32]
Amitay
Yeah, a lot of photos of him like an elf, him like a whatever. Yeah.
- [02:38]
Unknown Host
So cute. I just got the email from, from the thankful email. I thought it was with you and a baby and the wife. Good job.
- [02:46]
Amitay
All right, thank you.
- [02:47]
Unknown Host
Well, I'm gonna just kind of dive in because I know you're very busy and we gotta just get right to it. So obviously, you know, I launched Young Goose on my site and it's been incredible by the way, with the response. So I'm so excited to have it. Obviously I've had my experience with it. But I really wanted to get in a little bit deeper to some of the things I recommend. Of course, everybody's gonna ask me which line do I prefer. Right. And it's not going to be about which is better. It's just going to be. They're completely different product lines, which I love because I want to offer both. To have options for both kind of thought processes and goals and concerns. Right. So a lot of my clientele and my audience are going to have skin concerns that are based on like, you know, severe acne, rosacea, eczema, different type of, you know, perioral dermatitis, things like that that they're really struggling with. And there's so many different, you know, options that I work with in the osmosis line that, you know, really do help. But I know that there are also so many benefits when it comes to the Young Boost line that I really wanted to cover and get some of those questions answered. So if you kind of want to dive in to some of the things that people may not know about Young Boost and why it's so beneficial for people. Different skin disorders as well.
- [04:03]
Amitay
Yeah. So first and foremost, I think it's you. You hit the nail on the head as far as, like, people should use and stick with what they like. And I think every, every person is individual the same way we have different personalities. One of the things that makes or breaks or that has our skin react positively or negatively most to a product is actually the flora of the skin. So basically the microbes that live on our skin. The same way we have gut microbiome, we have also skin microbiome. And skin microbiome is an enormous part. It's like the atmosphere. If, if our skin is the living organism on the earth of our body, the atmosphere is really the gut, the skin microbiome. So we are all unique in that aspect. And a lot of obviously the things that you mentioned are microbiome related. So I'm just gonna skip all the, the, the. All the part of obviously people should. Should optimize their, their gut microbiome first to make sure that this is addressed from the inside out first. Having. Having said that, what we specialize in, Yang Goose, is the. Is youthful function is basically the ability of your skin cells, each cell individually, to access the optimal version of how your skin should behave. That's why other products that you. The person, you specifically, by the way, but also other people love and swear by would suddenly work significantly better. Because 99.9% of products on the Market right now deal with basically signaling to the skin or stimulating something in the skin which then the skin needs to respond to. The same way that an exercise is not what grows your muscle, your, your, your body grows the muscle in response to exercise. And what Yungus does best is kind of repair the, the youthful function of the skin. And obviously you can do it in many levels. That's what we have different products. So most of what you mentioned right now is a issue with the barrier function. And that becomes more and more, I think more and more talked about as time goes on, barrier function. And really I think 5 years ago I started talking about something called leaky skin and now it's not even associated with me. But you know, I, I, I like the idea that it, that it's out there making, making, traveling around. And I actually talked with Ara, Ara Peterson, which is the CEO of seed, and I told her, hey Ara, you know, what I actually meant was that, that our skin does not have leakage of material, of particles, which is what we think normally when we hear about leaky guts, it actually leaks of information. Our skin is a sensory organ and if it senses disruption, danger, our immune system senses something that shouldn't be there, it basically reacts to that. And that is why we have most of the problems that we have that you mentioned. Anything from dermatitis to rosacea to eczema. What we can do is actually repair the disruption, the information leakage of disruptors, of sensitizers, of molecules that shouldn't be relating stress to your skin layers and thereby repairing those things. So that is really, and by the way, what she responded is that actually that's what happens in the gut as well. It's not necessarily the particles that are the problem, it's that the, it's the inflammatory communication or the foreign object communication that is associated with it, which was very interesting. Which kind of full came full circle. So shout out to seed. Great probiotic. So first and foremost it is nad and it's very easy. I mean NAD is a very low hanging fruit as far as anything that we, that we would like to see change in our body. And that is because really if you think of what aging is as a whole or what youth is, youth is a zero sum between repair and damage, right? If we have our skin is repair is damaged every day. If our body is able to repair all of that damage, then we're not aging. But obviously that does not happen, right? The main culprit is the lack of nad. Every time there is shortage of nad, NAD is the currency for repair in the body. So the minute that there is lack of nad, we are facing with our body kind of needing to choose what it should repair first in our skin, by the way, especially past our reproductive prime, which is around, you know, 19 to 25, our skin is being left behind. Our body is prioritizing other things, but not our skin unless we do something about it. So supplementing with NAD topically and when I say nad, it is NAD precursors. They need to be nano sized, so they're small enough to get absorbed into the skin and they need to be liposomal so they are stable enough, they don't break down. So we have them, for example in our youth Product, Youth Daily, you3 Set Care Moisturizer Eye care, which I know is a product that you like specifically. So eye care has them. We have them also in naya Polish and in amplifying essence. So all of those are going to have these building blocks or these building ups for nib really, which is the currency for, for repair. That's number one. Because when we load our body with the ability to repair, it's going to go locally, by the way, in the skin. Because if it's not in the skin, a lot of people do any div drips, infusions or take supplements. The problem is, is again, our skin is not our number one priority as far as your body is concerned. And we really need to kind of make sure it gets absorbed locally where we want it in the skin. Then we see crazy results, especially for the things you're mentioning. Okay, why is that? It's because these already have inflammation associated with them. The body already knows they are a problem, Whereas it does not know a wrinkle is a problem, or it does not know a hyperpigmented spot is a problem, or it doesn't know laxity is a problem. Loss of fat, for sure, it doesn't know the problem. It's not there anymore. So these things require other innovations that will signal to the body, hey, here I would like repair here please. But as far as, as far as, you know, eczema, psoriasis, perioral or dermatitis in general, and rosacea, these are things that inflammation is associated with them. Therefore repair is needed. The second molecule that's super, super, super important is spermidine. I know most people would think spermidine is actually this autophagy molecule that would or out of phagy if you're in England. But basically the recycling of older material in our cells or older cells to newer cells. But really the same thing is happening in the smallest of organisms. So also our microbiome, our skin microbiome. So since they need autophagy as well, one of the, or the most effective molecule to repair our barrier and skin microbiome is spermidine and that we have in our youth products exclusively. So youth daily, youth reset, and soon also youth neck and chest and other products are going to come as well.
- [11:42]
Unknown Host
Yeah, that's, I mean that's something that I think is really important to note with these specific ingredients that aren't found in any other product line as far as, I mean, I can't say for sure. There's always little brands that start to pop up here and there. But anyway, NAD and spermidine combined, I feel like that is not something that I see out there yet. Correct.
- [12:02]
Amitay
So. So no, no. So spermidine, we're the only one and there always are. And, and nad, we are not the only one. But I think it's important to know that NAD is or NAD precursors, NAD building blocks and NAD the molecule. It took us from 2014 until 2020, a lot of what took us six years to do or five and a half years to do is actually to find a way for these molecules to stay valid, to stay coherent, to stay true to their form and effective while they travel to, you know, from Florida, where we ship them to Tucson, Arizona, where it's very hot, you know, or cold or anything, barometric pressures, anything in keep them valid. So there are companies that have NAD or NAD precursors, but by the time you're getting them, you are not getting NAD precursors, you're getting niacin, which is okay, but niacin actually isn't, isn't not. It doesn't do anything for the skin, good or bad. It doesn't, doesn't absorb well, et cetera. So they break down into niacin. It's to the basic form of vitamin B3, basically, spermidine. We're the only one within spermidine we know because we actually have an R and D facility which most people don't know is associated with Young Goose, but it's pretty famous within the, I would say the longevity community that is, that is looking at research. So we get a pretty large companies which we obviously cannot name, but you know, company that is doing $400 million and um, something crazy like a hundred thousand dollars every minute there on qvc, something insane. It has contacted us saying, hey, we have, we would like to do spermidine skincare. Obviously we tell Them, no, but we know of two other companies that are looking into it within Spermidine. Actually, the, the conversation should be very similar to Nadine where spermidine is a, is a catchy name. That's the end process of what's happening in the body. But in general, and I think we had conversation about collagen peptides last time we spoke. In general, our body does not. That doesn't work like that. It's not like whatever I put in is the way that it's going to live in my body. Our body likes to do conversions. It's used to do. Doing conversions. So actually spermidine, similar to nad, needs a molecule with precursors as well. Spermine and putresine, which are other polyamines that are, that basically create spermidine in our, in our body, in our skin. So the other companies that are going to come out with it and a lot of supplements right now in the market, not Spermidine Life, which we use, but other supplements in the market use synthetic spermidine that does not contain those precursors. And those precursors together with spermidine are about 10 times as powerful as fermenting alone.
- [15:04]
Unknown Host
Okay.
- [15:04]
Amitay
Yeah.
- [15:04]
Unknown Host
I have a question in here that I would love to get into. Somebody asked, what about mixing with other brands? For example, if I use a retinol now, I'll have your answer to this, but I will give mine. So there's two sides to this. First of all, I do know that Young Goose plays well with others. So I do know that you can cross combine Young Goose with, let's say Osmosis, right, Or product. Um, however, Young Goose has its own bioretinol, so I don't think there'd be a need to be using a separate retinol and a bioretinol. Correct me if I'm wrong about that in a second. But the other part is my skincare philosophies are a little bit different. Regardless if Yungoos plays well or not, I prefer to stick within the same family. And there's a reason for that, is because I want to know what's showing the benefits, what's working, and give it enough time to properly show those benefits, which come over a lot longer than people even realize. So whether it's Young Goose or Osmosis or any skincare line for that matter, when you have a product line that has like minded ingredients that are all working together, it's meant to be as a system. That's why I design systems. That's why I design, you know, customized protocols and work with clients one on one. Because whether or not it's going to be an osmosis system or a Yungu system, I want them to all be working together within the same family. I want all of these ingredients to play well with each other, but to also optimize, because that's the best way, in my opinion, in order to see the most beneficial results over time. I think what people really mess up with quite a bit with skincare is they'll give, you know, a line, six months, they'll run out, and then they'll switch to another or they'll start incorporating something else. Now we don't know what's working, and now we don't know if it's the line that you were already using for six months that's now just maybe starting to show the benefits, or if it's the new thing that you just introduced or, you know, and that also goes to say, with prod or, I'm sorry, with skin disorders as well, we don't know what the issue was that maybe your skin has plateaued with this specific line or that maybe it, you know, had a reaction to a different product. It's just too muddy, in my opinion. And I just prefer. And also just to take up the guesswork, I think that it's such an oversaturated market. There's a million products out there. Cut down the noise, stick to one family, make it intentional, make it that you are adding things or subtracting things as needed within that same line. But you have this focus. You. You can stay motivated with it and you have to give it. I mean, I always tell my clients, don't even have any expectation for at least a year ever. I just don't think that any amount of time, three months, six months, nine months, is even enough to be able to fully tell what a product line can really show and what benefits are really there. I mean, for me personally, it just gets better with time. So the more that I use it, the more consistent I am, the more I see those benefits, the more I see those results. So please tell me what you think.
- [17:53]
Amitay
No, no, I. First of all, I love that answer. And obviously we see eye to eye there where I. And the reason it's so important is because a lot of the things that a company decides on are contingent, are kind of trying to build a system within. Within a product line. And I think the most. The kind of, the clearest explanation to that is that there is only so much you can cram into one product. You cannot have A product that would have all the ingredients everyone ever needs. Right. So what companies normally do, they have a way of customizing a routine which normally, by the way, would be around the serums. And, you know, older companies would also have like a lot of different moisturizers for, for different user experiences, really, but they're going to have the same kind of active ingredients almost within each one. And, and really they're just playing with user experience and then, and then adjusting the routine with serums or masks, things that are really moving the needle as far as like active ingredients that could, that could differ so 100%. I'll give an example. We have a molecule that we love and is becoming popular. We own one of the patents around it, but there are many more, which is, which is called ectoin. And ectoin is a protein that actually structures water around other proteins like collagen and elastin. And I call it everything hyaluronic acid wished it was. But we cannot have it within every product because it does not play nice with every product. And it. So, so we kind of count on. We're saying, okay, not, not everyone's going to use the amplifying essence, right? But we're going to put it in Amplifying Essence. You three set Serum Youth Daily Moisturizer and BioShield SPF 40. And we know that combining those, you, you really saturate the skin with the ectoid. You know, using one or two would give you some benefits, but it is not the complete system that we would hope someone would, would have. So, so I agree with what you're saying.
- [20:08]
Jamie McGuire
One caveat.
- [20:09]
Amitay
I'll, I'll, I'll, I'll introduce there. And, and you know, before I introduce the caveat, I would say as far as, like, your, your, your, your what you're telling clients, which is like, if you're seeing results within four weeks, the. You are not seeing results because of the real active ingredients of the product.
- [20:30]
Unknown Host
Right?
- [20:30]
Amitay
You are seeing results. Maybe the results, by the way, are not good. Why? Because we know studies show many, many studies show that when introducing new ingredients, like the actual ingredients to your skin, that higher concentration of ingredient that your skin did not recognize before will have your skin go into a state of preservation. So it activates a lot of longevity pathways. And then your skin builds some kind of tolerance to that ingredient and those, and you really cannot replicate this over time. And then people say, oh, we're not, I'm not getting results anymore. But the results are not because of a specific molecule. It's a reaction to a new molecule. So your skin is doing it by the way. It's not the, it's not the ingredient. Um, and I agree with you that over time that's when you know true longevity youth promoting ingredients shine obviously.
- [21:32]
Unknown Host
Yeah.
- [21:33]
Amitay
The caveat I put there are, there are people that their skin really agrees with a specific product. I think a real role in their longevity game or their skin health game, know what specific product or products really do make the difference in their skin. And then introducing products like Young Goose again because we are excavating, we are revealing the ability of your skin and there's this. The reason I say revealing it's because we do reveal the DNA encoding of youthful function in the skin. If anyone has ever heard about David Sinclair or read the book Lifespan or heard about the information theory of aging, that is what we're doing. We are correcting the patterns of DNA that exhibit youthful function. And by doing that the, the products that you like that really move the needle for you would work even better and better and better over time. So there is a caveat there.
- [22:34]
Unknown Host
Yeah, I completely agree with that. And that's the thing that I just want people to if they're in the skincare game, like how you and I where they're really invested in achieving these skin goals and getting their skin super healthy. And the longevity thing is something that I am a huge know believer in. It's, it's all about how do we get you to achieve long term skin health. I don't want you to, to have a few products that are just going to maybe promise, you know, overnight success which is a bunch of bs. SA.