← Biohacking Beauty: The Anti-Aging Skincare Podcast
Biohacking Beauty: The Anti-Aging Skincare Podcast
Marina Moiseyeva: Skin Detoxification, GLP-1s, and What Actually Drives Facial Aging
01:09:13
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- [00:00]
A
Before we dive into today's episode with Marina, I would love to read a review of one of our lovely listeners. And because it's only me today, I am going to choose a review from four years ago and see if this person is still listening. The review is from Jake RB and he's saying, I've been listening to this podcast for the past year and I must say it's been my favorite podcast to listen to. So much knowledge about biohacking must listen. Let's see if he indeed had to listen for four years. And if he. If you did, Jake RB email us@serviceungoose.com or you can DM us on Instagram young gooseskincare and you're gonna get a free product. Yeah, let's see. That's a nice one. Let's. Welcome to the Biohacking Beauty Podcast where we explore skin aging through cellular science and regenerative biology. In today's episode, I am joined by functional medicine practitioner Maria Moiseva to unpack skin detoxification, GLP1s and the deeper mechanisms that actually drives facial aging. We get into why certain topical treatments and medications increase detox demand, how sweating.
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And lymphatic flow support skin longevity, why.
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Protein deficiency quietly accelerates aging, and how popular detox trends can backfire when they ignore basic biology. If you want to understand how the skin functions as an active detox organization and how muscle, bone and protein loss shape changes often labeled as ozempic phase.
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This episode offers a clear, grounded framework.
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A
To make sense of it. Marina is certified in Anti Aging and Regenerative Medicine, a member of the American Academy for Anti Aging Medicine, and the author of Harmonious Healing, Biohacking Regeneration and Health Resilience. Let's dive in. All right, Marina, welcome to the Biohacking Beauty Podcast.
- [02:31]
C
Thank you, thank you. Such a pleasure.
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A
So we kind of started talking off air and I said, you know what, we're going to keep it, we're going to save it for the podcast. So maybe, although it's, it's a rarity. Let's start with, with talking about how you've gotten to where you're at. Like, how did you get interested in, in health and skin health specifically?
- [02:52]
C
Yeah. So I am being in integrative regenerative anti aging medicine, functional medicine, and nutritional aspect of it for over 16 years. But truly what gave me an interest in it is my personal skin concerns are so, you know, I actually had a skin concerns since teenager, but at that point, you know, it's obvious everybody has it and then I Had like terrible sunburn, which also had to kind of take care of. And. And again, my grandma was doing natural herbal kind of like elixirs and different like type of teas to put on the face. Then it developed terrible rosacea. So. And then when I, at 18, I came to us and even though at that point my skin was pretty good, I started a new cycle of skin concerns, like, and they were terrible. I would say the worst of all, the combination I had in my early years. And I was like, puzzled. I knew I'm not like already at puberty, you know, and I didn't really change anything. Everything was just great. And I. I couldn't understand why all of a sudden I have the worst skin ever. And it got me to really think after literally being in the US For a few months, I was like, what did I do differently? I wasn't really eating a huge big different of a diet change. But overall, then after analyzing, I realized there's something else. And it was definitely the sugar, right? The sugar that was like, different. And overall the food was different, having different effects. And that's how I started treating myself because I was going to the best dermatologist. I went to many of them. And it was not getting anywhere. It was just getting drier and redder. It just was actually super not helpful. And when I was kind of searching and was trying to play with my diet and literally this is how I got into actually how nutrition affects how our bodies work and how our skin looks. And that's pretty much how from my personal interest, I was basically then, because I was already going through nursing school and I was figuring out that just besides my skin, I see other patients who are literally were just recommended for blood pressure, you know, let's say blood pressure medications or cholesterol pills or just literally just take a pill. And I was like, I'm sure for every single kind of like condition, right, you can have a good kind of aspect of it. You can treat or definitely improve and problem and cure with their nutritional set of kind of aspect, right? So. And overall, the dream of my life was really in those early years is really if I ever were able to go makeup free. But seriously, right? And that's literally amazes me these days that Even though at 40, which I'm right now, right, typically people start like doing things to cover up the skin. I'm actually going make it, you know, so that's awesome. And this is really how much this whole are nutritional. And there are, you know, all the aspects of their. How you can heal yourself and what you do to your kind of body can affect. And again, you cannot deny that skin is there, literally the biggest organ and it's really your mirror of what's happening in your body.
- [06:03]
A
Yeah. And a lot of people don't consider the fact that whether you're. You're applying something on your skin for an acute, you know, condition, like to treat something specific or you are taking any kind of medication, anything that really kind of is being taken as a solution for a specific subject, you are, you know, almost as a rule, you are increasing the demand on detoxification as a whole in the body.
- [06:37]
C
So you were saying in terms of any topical thing you would do for your skin for. Even, even if you get results, even if you get a result, as you said, it's kind of puts your body in a kind of harder mode and more things to detox. I mean, I totally agree because I would see the best, I mean the best things in terms of that. What works? Definitely typically people prescribe some type of steroid or some type of even immunotherapy related skin care. Yeah, my dermatologist, which is definitely way goes way beyond your skin. And especially when it comes to steroids, they do have anyway. But even though light but in kind of systemic effect. So it does definitely increases a lot in your body and overall you going to deal with other things. And plus it's definitely only a band aid treatment type or so you never.
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A
Even if it helps? Even if it helps.
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C
Even if it helps. Yeah, it's really kind of just works for now and you never really get to the core of it. So I do see a lot of patients who have psoriasis, eczema, seborrhea, dermatitis. And literally even though they are happy with the treatment by dermatologists frequently, you know, I mean actively continuously using the cream, they do not understand. It was a clue, it was a hint, it was a signal from the body to really look deeper, not just cover it up. So it could be the only symptom. You know, sometimes you're surprised. Let's say people eat a lot of sugar, people just overall overeat or just have a bad diet. They might have no diabetes, they might have no extra weight, no other blood work. Actually things that are kind of looking suspicious. But they could be the skin where you show the things. Let's say you get pigmentation, you get redness, you just overall it looks a little kind of like citrus, like texture. Right. So yeah, it could be skin is the only organ that shows off in terms of their actual symptoms.
- [08:33]
A
And it can even go beyond that. Meaning even if you take, if you're on ssri, if you are on any type of, any type of again, medication or any type of support to a specific organ, at the end of the day, there is a higher demand on detoxification. And that by the way, is shared by your skin. It's not necessarily only by your skin, you know, whatever it is, liver, kidneys, your detoxification system now needs to work harder and these things accumulate and you need to make sure that you are detoxing well, that you, that you have the ability to detoxify from your skin as well, that you're supporting that or else you are going to develop things or even just, you know, early onset of skin aging for that matter. Because you are not supporting the skin is a detoxification organ.
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C
Correct.
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A
Yeah. So what do you think is the biggest mistakes people make when they try to detoxify their skin or they're not supporting skin detoxification?
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C
I would see skipping hydration and sweating as the biggest detox kind of overall organ system. And they're just how it works. It really covers so much more than you can do with other things if you do not have your detoxification pathways open. And again, if you want to just support their fundamental stuff, you need to make sure you're well hydrated. And sweating is there honestly one of the most efficient way to detox. Right. So but if you get, you can really detox through the skin well, even if you sweat, but if you're not drinking, it's just going to be stagnant system.
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So.
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And again, sweating, ideally you want to do some type of physical activity. You can do just on top of lymphatic drainage. You can even look just do jumping jacks. But it's really something that is going to make you sweat and, but if you cannot really sweat efficiently because you're not drinking sufficiently, that's going to be not efficient.
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A
Yeah, you're touching on, on a couple of good points here. The first is sweating as a whole is a, is a way to detoxify. Right. But you also, you know, mentioned lymphatic drainage and, and jumping. So this is something, I think a lot of people don't realize that in order to support their lymphatic system they can do some kind of, I would say on and off G force type things. It could be, if you have a huge swing in the house, it could be good. But mainly, mainly jumping up and down. Right. Like trampoline or jumping, you cannot really.
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C
Make an excuse not to do it. Yes. Because let's say when it comes to lymphatic system, the trouble with that is compared to cardiovascular, you know, our flow of the fluids when we have a pump as a heart. Right. Lymphatics are totally dependent on our movement. So it gets really stagnant and stuck if we are not providing. And just kind of the easiest way is like little trampoline or literally just jumping jack, something that's actually jumping. That's the easiest way to activate it. I mean, people do a lot of, like, there is so much. There's different, like, equipment are right now, so you can just go for therapy for a session where they do like a nice, very deep lymphatic massage. But if it, you know, if the matter of like, mind your time. This is literally very efficient and just like free, you know, it's like.
- [11:59]
A
Yeah. And the. And the. And I think the one that encompasses both, obviously, as you mentioned, sweating and lymphatic obviously is working out. So, you know, the lymphatic system is built to be pumped by our muscles when they're moving, obviously sweating when we're moving. So these two things do indeed work very well together. I mean, the face, you might need to work a little bit extra to massage the face to help lymphatic or vibrate your hands around your face. I've seen people who are into facial massage doing some kind of light vibration with their hands. But these things are. Are definitely, I mean, free and. And easy to do.
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C
Right?
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Yeah. So we've started this conversation talking about nutrition. Where do you see most people that come to you? How is their nutrition? Is it because they come to you? They're already people who are very aware of healthy nutrition, or do you feel like most people have the idea or the awareness that they should hit eat healthy, but they really have a hard time understanding what that means?
- [13:10]
C
I mean, I do have honestly, a range of where people are at their relationship with nutrition and food partially. You know, these days, there's so much information. So most by now comparing to like, let's say 15 years ago, when I was just early in my practice, some people really had no idea that what you eat would impact your health. I was surprised. You know what? People are totally clueless that, you know, eating burgers and drinking Coke is bad. That right. Right now I don't really have people who totally have no idea that this is not great for your health. But still some people keep doing it because of their. I would Say life strains in terms of like very hectic lifestyle and family or a lot of demand and it's just easier convenient. Sometimes they understand they're doing bad thing for their body, but it's just how to break the cycle or what to do what kind of seems to be very convenient and just you know what you're doing. Right?
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A
Yeah.
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So. Oh yeah, at this point just to help them slowly but surely change the habits. So it becomes an easy habit change. Right. So kind of. Or switch to something that's kind of gives them the same effect in terms of let's say, let's say somebody who still relies on soda even here and there. Right. So what exactly they want from it? Or is it like literally they want the caffeine or they want their bubbles or they want their sugar part of it. Right. So you can find a lot of healthy alternative even in a can. Let's. Even in a can you can do it even like probiotics, kind of fermented tea. But it's a totally game changer in terms of the effect versus like truly high fructose corn syrup based Coke. Right. Or even, even diet Coke. You know, it's still obviously very toxic and very terrible for the skin. Even though in a lab this aspartame would affect, would show zero effect and zero sugar. But it doesn't work the same in the body. So it doesn't. Then this doesn't end up in real life. Even though overall the idea of the sugar effect should be not happening.
- [15:10]
A
Yeah, it's very smart what you just said because we really are bad as human beings and even if someone is right now listening to us and they're like, hey, I haven't had like a Coke in 15 years and my nutrition is on point, they could look at other parts of their lives. It's extremely difficult for us to understand the effects of incremental decision making. So it's just, you know, every time you reach that decision, you're in front of that, you know, pie or something, it's just another pie. It's not the story of the accumulation of all the pies you've eaten before and all the ones that you're going to eat after. So what you're saying, where the habit should be built slowly and with providing alternatives, that's a game changer and that's something that everyone can really apply. I think some of it is making sure that the alternatives are available at the point of decision, that it's not a harder decision to make from an energy expenditure point. Right. Like if I, if I have zevia or whatever or a probiotic drink, whatever they're called, like kombucha in the fridge, then it's an easy decision to make. If I now need to, you know, cross the street or whatever to buy something else and have Coke in the fridge, that's a harder, it's a harder decision to make. Right?
- [16:34]
C
Yeah. That's why it really, in terms of lifestyle overview, it takes the biggest part of the session with me and my patient because it's really, I, I can create a perfect regimen, right. Or just kind of standard guidelines, standard recommendations, but it's not really working. Right. So I need to understand where they are, what's their circumstances. And even though it might be minor change, I know it's going to have really long term amazing effects. It's not going to be, let's say three pounds down in a week, but it's overall going to make him feel better. And if they keep doing this change for 30 years, you know, that's going to be just saving the life at some point, you know. So, yeah, it's really meeting where the patient is at, not where I want them to be perfectly at. Let's say if somebody's really literally eating burgers and drinking Coke, like I'm not telling them to go to Whole Foods and cook at home, you know, it's just not happening. So it's really to see where is that little change is going to make a big effect long term. And it's something that sounds super physical, it doesn't sound like a stretch. And then when they feel it's actually not so hard and it's doable and they keep up. So between our sessions, you literally, I just want to make sure they feel like they are not a failure. Right. Because I give even though obviously the best plan, recommendation, nutrition and lifestyle, but I know it's not achievable, not reasonable, not possible. They just going to completely effort because it's just not realistic, you know. So yeah.
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- [19:31]
A
So the other, the flip side of that is that in today's world it's becoming increasingly difficult, especially if someone is also taking the route, especially if someone's taking the route of weight loss injections. It's becoming extremely difficult to actually get all the nutrients that you need through food. Again, especially if someone is on a weight loss injection which actually makes it. Makes it so they derive less nutrients from the food that they're eating. What is your general or how do you view IVs as a. As an adjunct to filling in deficiencies?
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C
IVs are based. I mean obviously would do amazing here when it comes to nutrients. Right. For people as you mentioned now a big chunk of population I think it's actually by statistics 30% of population either tried it or did it right now. And I think actually it's going to get even higher because you know, with coming out of more safer ones and overall with so much data actually in its favor, even though how much I was originally when it was coming out against it. I'm also now in many cases, I mean not many but I would be open and sometimes even recommend it because depends on where they are. It sometimes really gives a push and really saves some literally life because if somebody already has a list of medications or literally, you know, have a bunch of conditions that are chronic and they are because of the weight or they literally have a cardiovascular concerns, it definitely can speedily get us in a better state and not to keep damaging your body because unfortunately let's say sugar or high blood pressure, it's damaging your vessels and damaging your kidneys and damaging every single organ system. So you want to kind of honestly just get rid of this internal fire and then kind of teach them along the way how to do it long term lifestyle. So it just depends where people are and in terms of IVs are definitely in nutrient wise are you can cover it a lot. Right. So first of all I definitely advise when people are getting on those shots sometimes. I mean frequently it's just prescribed, but in regular traditional endocrinologist and everybody's happy, but nobody really checks in and nobody really does an extensive nutrient and mineral analysis. Right. So you don't know what's going on. Your sugar is getting better, you overall feel good. And. But then something starts getting off, let's say two years down the line, right. Because now people, a lot of people do just keep taking them. So really you need to work with somebody who can run your very comprehensive nutrient profile. Because even let's say if you're smart and you're doing multivitamin, right, you don't know exactly what you kind of getting accumulated. And plus even the fact that even if you take multivitamin on their GLP1 shots, right. Are you still risking not absorbing it? Well, because that's the problem. You might be getting it, but there is definitely been a study, even let's say birth control and GLP1 combination, people get pregnant because you're not getting it just does not get absorbed the same way. So you're probably even you thought you covering, you could be slacking big time. So in terms of, you know, IVs, nutritionally from the standpoint, vitamins and nutrients, perfect. Yes. Get your levels checked and get nutrients even on a monthly basis. You know, and this is even, you know, some people who do not take injections, they might be just having trouble with their digestion and absorption, you know, even without the shots. But the only thing that you cannot really do as good with their infusions is protein.
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Yeah, correct.
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C
That's it. And sometimes people would say, you know, ozempic phase. But in reality it's really, people say, oh, something happened to my skin because of the shots. But in reality, because again, if you lose fat, you're not even losing muscle, it will give your face a different look. Right. And especially when people, even a man lose a lot of fat, they going to look older because you know, men who are overweight, they already kind of really produce estrogen from this excessive fat. And estrogen is amazing in terms of collagen boost and in terms of overall skin glowing and being better. So this is another aspect why skin looks so much worse if they lose weight because it's so many things. Estrogen going down because testosterone too, testosterone.
- [24:18]
A
Is great for skin thickness too. But there is an, I think there is a little bit of a silver lining here really because as you said, most people that are going to take GLPs or whatever, whatever version of, of skinny shot there, we're going to have in the future. Haven't taken it yet, right?
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C
No.
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A
Oh, I mean like the future is really. That's stupid to say, but the future is in front of us. Right. So here is the issue with. So, so I'm actually thinking that it's fortunate that one of the first discussions around the, the visible effect, the negative, visible effects of GLPs or weight loss injections are what we call ozempic phase, ozempic butt, ozempic belly, whatever that is. And why is that? That is because these are short term changes that we know how to tackle. We can tell you hey, lift weights, eat more protein, you're gonna be fine. For the most part, obviously weight loss, what comes with it is, is definitely changing of volume. But long term, when we're gonna see people either microdosing or full on, you know, taking weight loss injections, we're gonna get, we're gonna start to get to the point where we're gonna get bone loss and obviously muscle loss as well. And that's where the real problem lies because bone is especially in the face especially. It's so difficult to remineralize. It's so difficult to kind of do redensify the bone. And, and we know it from people that have anything from tooth decay to people who have deficiencies growing older. Right. That is where the, what the future holds if we don't correct the way we approach nutrition and nutrient replenishment during those what really are absorption limiting injections. That's what they are. Right. So yeah, I mean I think, I think it's, it's, it's, it's a good discussion to have now in the beginning, you know, in business you say you should have things kind of hammered down in the beginning when there is no money on the table because with more money come. Everything is more grave in, in its decision. And the same thing here. It's good to start the discussion now when people are not happy with maybe some deeper lines or a little bit droopier face before we're talking about serious, serious, serious conditions that also affect how you look.
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C
Yeah. Just having I think an honest conversation in terms of really advantages and disadvantages and long term effects. Just kind of saying if you really just want to give it a kind of jump start and then we kind of clean up your nutrition because it's kind of also, I would say easier to really especially I'm talking about more like extreme versions when people are really not eating regularly. Just overall the diet anyway poorer like no much of nutrients anyway and they have trouble Especially with portions, it's just so much easier to give them to eat proper because overall the appetite is lower. Right. So it's, it's a good time to actually it's easier on them to change the lifestyle. Right. But at the same time to kind of save time and to prevent further damage. So. But overall I would say with all this, obviously you see in microdosing and a point of bone density which is the worst effect, which is again pretty much non reversible in terms of how your face changes and you're going to think what's actually happened. But that's why women in menopause, this is such a big difference four or five years after stopping of cycle because loss of collagen on top of their already like osteoporia, osteoporosis like their bone density loss because of also hormonal changes alone. And if you add up on that actually the shots, it's definitely going to be super pronounced and it's extremely hard to reverse. I would say, I would. It's almost impossible.
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It's impossible. And it is, it is, I think to say it's an uphill battle is. Even if it's possible, it is.
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C
So.
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Much harder than kind of the maintenance.
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If you prevent it or just kind of do consciously. That's why in general I especially really feel terrible for people who go for those shots. And look, let's see, look. It's a bunch of people who would just get it illegally or because the front doing it, they just have leftovers or just like, I mean you can imagine people just get it here and there without even doctor being a part of it, you know, or because they can't have access or you know, now you can actually buy it online without having a license.
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You know, but that's, but then first of all, I think we're gonna, I don't know how it's gonna go, but there's gonna be a lot of back and forth. There's gonna be a lot of like regulation loopholes because there's so much money to be made. Right? Regulation loopholes. Regulation loopholes. Even we saw it with semi glutide in the beginning there was just a shortage. So the FDA was like, hey, you know, people can compound it in pharmacies, they can do it. Then there wasn't a shortage. You can't do that anymore. But you know, when as science progresses, I think we're going to see this back and forth with those, you know, what, what, what we call an anoretic or appetite reducing Drugs. Right. Which, which do make dieting more sustainable. I mean, like, there is no. There's no. There is no. We know, we talked about, we talked about sugar. It improves glucose regulation, which even, you know, improves your relationship with sugar. So if that's something that you need to fix in air quotes, you could have an easier time fixing it when you don't have a crazy craving. Inflammation. We've, you know, especially inflammation in the brain. We've. We know through studies it impairs your decision making if you have an easier time because Gl GLP gips what I mentioned, those skinny shots, they reduce inflammation, less inflammation in the brain. You can make better decisions. Better decisions lead to better habits which make. Which lead to easier decisions. So again, like, I think there is a lot there in the, in the pro camp, but we, you know, it's almost like you, you never can have free, free ride. There's always work to be done. We've seen it by the way, even with people who are going vegan, right. Which is the, the, the last decade's fad, maybe go vegan, you're going to be fine. But people what, what happened. You had these, these months. These, these Frankenstein's like beyond meat or whatever. Right. I'm sure there are many. I've. As you can see, it wasn't my. For the fat that I subscribe to. However, you've had all of these replacements. My brother still eats Saitan every day, which is, which is basically gluten. So what you've had is people that are trying to keep the same simple, I'll order something from Kentucky Fried Chicken type lifestyle. But now vegan, there's no, there's no free ride. You always have. It's always the work, the work volume that you need to apply. It almost stays equal now that the question is like, what is right for you and what do you want to subscribe to as far as your belief system? I feel like almost.
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C
Yeah. I just want to kind of clarify because you were mentioning like skinny shots just for people who truly know the skinny shots. Because in our actual medical world there is a skinny shot which is not GLP1.
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A
Okay.
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C
So those are actually good ones.
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A
Okay. To be honest, I invented that term right now. I didn't think about it.
- [32:28]
C
Yes. When you think, when you're like confusing me because skinny shots, there is a name of officially kind of like skinny shot. It's basically a mix of a few B vitamins and a few amino acids, which is good because that's. Let's literally B1B6B5B12 and if the four amino acids inositol, methionine, L, carnitine which are actually just naturally support your system to affect your society, your overall fat burning capabilities. And look, overall they are skinny shots by the actual official name, but they are not related to peptides and hormones. Right. So yeah, but you are referring pretty much to the straight this kind of JLP one generation, third generation kind of group category. Right. So yeah. In terms of their, you know, when it comes to the GLP1s obviously as I said, it's going to be like a back and forth. And the fact that you said about better decision making, there is a lot of studies and again also I see that in my practice when it's actually makes sense, it is really saves a lot of health concerns and improves health in general when people have different type of addiction. Right? Yeah, because it's definitely been amazing. When I saw it first with my patients, I was thinking it's just kind of like a coincidence. Right. Let's say people who've been drinking alcohol.
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Right.
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More than need or overall these days it's kind of based on research. There is no amount of alcohol that's for brain wise even a little bit alcohol seems to be affecting our brain health. Right. Because before it was kind of a debatable and it was moderate and probably Pinot Noir or Cabernet Sauvignon. You can do a glass, a couple of glasses a week for the kind of actually antioxidant effects of resveratrol. Lately, the more research we see it seems to be. I don't know if the wine has changed or in general it seems to be there's no kind of basically alcohol serving that would be actually health protective or health kind of like promoting. Right. So it seems to be like we are done with alcohol part and in General Again, their GLP kind of want whatever second first generation or third they've seen. They've been really helpful for people who are besides sugar addicts, literally addicted to any substances, literally even smoking like weed, you name it. And even they say with addictive behaviors, you know, in terms of people who are shopping excessively or people who are gambling. This is like totally I think really interesting. And again that's also. Sometimes it makes sense to use if that's really screwing up your life.
- [35:03]
A
Yes. You know there is I. There is much to talk about here. There's also ways to obviously it's, it's. It's annoying to say what, what studies do they tack on Other drugs. Right? That's, that's what happened. It's not like, it's very difficult to find like a, like a pool of studies which, which explored having a solid weightlifting and, and protein intake routine prior to GLP1. Like it's going to be so difficult, understandably going to be so difficult to source people who are going to be good candidates for like on, on a large scale, like 300 people that are going to say hey, I also want to subscribe to the study where I lose, where I lose weight but also let me have a good weightlifting routine two to four times a week beforehand. So I mean it's, it's understandable. However, I would say that there are studies showing that there is one specific one called the Regeneron Primate Study where they, they had GLP1s and dual myostatin activin inhibition, which is like things that make you grow muscle basically. And that showed that you could have a lot of the benefits of GLP1s without the adverse effects of ozempic phase for that matter. Having said that, I think it's missing the point of the work that needs to be done in lifestyle. In my takeaways, like if someone asked me so okay, so and maybe and I would like to hear your opinion about that. If someone asked me, hey, I'm starting this GLP journey, right? And I'm so tempted to call it Skinny Shot again because I just made up this term but it's not okay, but I'm starting this, this journey. What should I do to preserve my facial whatever my facial contouring or whatever that is, right? So I would say first of all, strength training two to four times a week, high protein, high intensity and volume to, to, to, to basically build muscle. But you could think of it as preserving muscle at that, that point and really use the, the, the GLPs as, as appetite suppression rather than something to totally rely on. Yeah, to totally.
- [37:29]
C
Yeah, yeah. So I would add, you know, in terms of the protein, it gets a little tricky because as you said, even let's say if they use just the minimal that gives them a little help and the rest is just easier to get into their healthier lifestyle. In terms of protein, let's see if you take about food shakes or I mean acids, right? Like just so because again, IV wise you will not be able to do as many to keep it good because you need it on a daily basis a solid amount. So you cannot cognitive, I mean acid IV every day, I mean every even week. So I would say adding to Your in terms of exercise, protein wise, let's say food wise, make sure I would even usually give enzymes, plant based enzymes or even it could be as easy as artichoke and like you know, just something that naturally. Or digestive bitters, you know, just something that naturally can help you digest it quicker and better. And so if you eat, if you rely solely on the actual food like eggs and meat, you know, if you do not do any supplemental protein that's easier to digest, right?
- [38:35]
A
Yes.
- [38:36]
C
Because that's. Even if you have it perfect, it's going to be hard, it's going to be slow and overall that's why a lot of people start feeling nauseous because the food's sitting there for hours. You know, I have a patient recently, she didn't mention to her GI doctor she's doing GLP1. She went to the upper endoscopy and she ate last time 6pm 6pm and she had endoscopy at 12pm it's been pretty much whatever 18 hours. And he was like, oh my God, I don't know what's going on with you. You had stomach full of food 18 hours later and you know she could have died because he would choke. You're not supposed to have food even like six hours, like even four hours kind of. It should be going down. So that gave her actually a realization and this is how it was easier for me to now convince her to get off because she was in it for a couple of years, right. And she stopped right after and she'd been keeping this weight has been ready to kind of like for a while. But that's kind of. People don't understand that even if your system was fine before, you really are changing so many things. You know, the point is medication as you said, you always gonna get other things you're not subscribed to. You know, because when it comes to let's say any, any other even natural things, let's say are supplements. You. Let's say you take green tea extracts for fat burning capabilities. You also getting in addition like antioxidant properties. You getting other things you didn't subscribe, but they are positive. Right. When you do subscribe basically start doing anything prescription, you're getting something you intended kind of good for you, but you're getting things that you are not willing and interested in. Yeah, and this is unevent because it's just you close one pathway and our body is just so complicated. It's not just one thing covers and addresses this. You're getting so Many chains of reaction impacted that you are really changing the whole body, how it works, how it functions, even though it's easy, one peptide, you know.
- [40:32]
A
Yeah. First of all, another way to look at it is, you know, starting small. There is a lot of longevity modalities, a lot of longevity ingredients, supplements, whatever, that work really well on very simple organisms. And when once you become more complex, whether it is animals, humans, they stop working. Why am I bringing this up? What's the. What's why? It's because it's to contrast that with something that indeed does drive results. Not necessarily longevity, but results it needs to it. It inevitably drives many different processes in a complex organism, and a lot of them we are not aware of. Years into the. Into the journey with that specific for better or for worse. By the way, I think, you know, GLPs are going to be in the future looked at as a type of longevity modality to a certain extent. But yeah, one thing I would mention, because you mentioned endoscopy, and that's something I've never thought even to. To talk about. But if you are going to go to a. To do any type of cosmetic procedure, whether it is laser or microneedling or whether it is plastic surgery, you. It's really not smart or not ideal to be on glps. Yeah, it's just not ideal. Not only because, you know the fasted aspect, but also because you are creating stimulation to which the body responds by healing. And for that, you need nutrients. Right.
- [42:28]
B
Let's take a quick break from this episode to discuss the skincare that makes big promises but delivers small results.
- [42:36]
A
We know how tiring it can be.
- [42:38]
B
Yungoos isn't playing that game. This is longevity science for your skin, where breakthrough ingredients meet real results. For example, our bio barrier formula features LPC6, an antioxidant that's 20 times more more powerful than vitamin C. We're talking triple action defense against every type of free radical that ages your skin. And our revolutionary spermidine serums, the first skincare products to harness this cellular powerhouse that literally triggers your skin's renewal process. Every Yungoose product targets aging at the molecular epigenetic level. NAD precursors that restore cellular energy, peptides that rebuild collagen, bioidentical compounds that reinforce your skin's natural defenses. This isn't surface level skincare. This is your skin's biological reset. Whether you're dealing with dryness, signs of aging, or just want skin that actually looks as good as you feel, Yungoos has cracked the code on what your skin really needs. If you're ready to experience what happens when you're. When science meets skincare, check out the Yungoos link in the show notes or go to yungoos.com because your skin deserves the future, not just another cream.
- [44:12]
A
Do you have a protocol? Protocols, you know, kind of going off GLPs. I. There's so much to do there. Just I'm going to mention if someone wants to look into kind of what I said about how to not lose muscle, I would look at just Google something called GDF8/actin A +GLP1. This is the study I mentioned before. It's very interesting and I think it's going to be kind of the stack of the future. Having said that. So do you, you know, do you have a protocol for people who aren't are kind of coming to you and say, you know what, Marina, I just got divorced or I have a wedding in eight months or fill in the blank, you know, I've, you know, that's it, the kids left the house, whatever that is, now it's my time, I'm taking this on. I want to look my best and I'm going to do a bunch of things. How do you communicate with them? Do you just tell them, hey, you should be really healthy for that or do you, do you have a protocol where you're saying, okay, let's dial up everything to the highest. It can be as far as like, you know, as far as like how your, how your cells function, youthfulness in the body, how do you view it, how do you communicate it? What, what's your approach there?
- [45:26]
C
I mean, it's very personalized because I need to understand and do baseline workup in terms of body composition so we know where we started. And then typically if somebody really wants to go this route with GLP1 or you know, any of those generation of those peptides for appetite suppression and sugar control, they are on at least monthly body composition. That checks fat, water content, bone density and just fat. Because again, when they do it with me, I do not even have people who would lose muscle. Let's say I see them striking. I'm like, I'm not prescribing you, I'm not giving you, I'm not like doing this if you are not keeping up your muscle, right? So like that's why they have to be mandatory monthly for weight chicken. So we can see what they lose. And if we need to up the diet in terms of protein or again, it could be shortcut arts and as you as I said that if somebody just wants to do food, you know we do the food just add the digestive natural kind of support so they can actually digest it better. So besides that it's going to give them side effects. They're just going to actually get the nutrients, get those amino acids from the food and not just feel kind of like full all the time. And then if somebody I see cannot because you know frequently even if somebody has best intentions to eat enough they just can't feed it because it just feels like they're going to straw. Right. Cannot. So it's like I'm sorry, I'm not hungry. I don't know, I'm not gonna do it right. So another one is just quality protein shakes. But it's a little trick in here because if you've seen there's a lot, a lot even the best organic shakes coming up is contaminants with levels of toxins that are like totally not great. They really health risks. So it's a little tricky with this one. I mean typically if I recommend I recommend the one that a protein Shakespeare by professional companies not you know whatever you can buy on Amazon is somebody who created and doctors of functional medicine who are behind it and those are usually I mean hopefully are the cleanest and the best. And if anything I frequently I would say honestly in terms of protocol everybody goes on amena assets on GLP1 everybody. It's just a matter of how much more food or shakes we need. But I mean assets it depends on how many servings because those are something you do not have to break down. You don't have to worry. It's ready to use And I really use the cleanest one the one that doesn't load your liver or kidney and it's zero calories. So you kind of really getting this whole thing for their basically muscle support. Right. But without adding calories or something to digest. But it's tricking the system because you're getting the nutrients because how many times people would eat 2,000 calories but get zero nutrients? Right. It's not about really we're not we need some calories obviously but it's more about the nutrients we are meant to get from the food. So amino acids are really the way that everybody on in just the matter of servings they would have to do depends on how the body composition changes when they do those monthly check ins.
- [48:26]
A
Yeah. By the way I've been. You've just triggered something that I've been on personally. Did you hear about the New. The new information about creatine made in China.
- [48:38]
C
Yeah.
- [48:39]
A
First of all here's the journey that. Okay so basically there is information starting to kind of you know come out there that basically there's obviously less regulation in China and most companies like even very big companies source they're creating from China and there's a study that came out that they are that that it's not peer reviewed but there is a study that came out that tested Chinese made creatine and it had 18,000 ppm of a compound called DCD or D cyan D. I don't remember how to say it but this is basically like it's an impurity. It's basically heavy metal associated with really bad, really bad health effects, brain effects etc. Proven to cause harm. Another one is DHT dihydrotriazine. I think these were the two most like dangerous compounds there were there but a bunch of like heavy metals things like that. And, and. And then there was recommended. There is. There is basically like two companies Korea Pure and another one where they're made in Germany. Something. Yeah people can google it where they don't have these impurities. But then I looked at companies that actually use those German German suppliers and they're almost non existent. Like I try to find out where Thorn sources they're creating. They. They don't want to tell you. So I mean.
- [50:12]
C
Yeah you tried. You know I use my. I take mine from Thorn and I do have in my practice Thorn creatine because it seems to be an overall pure one. But I'll try me do.
- [50:23]
A
That's what I think just for to be fair that's what I take right now. I take Thorn creatine and but the thing is is that that I mean something.
- [50:34]
C
I mean it's an issue overall obviously with older kind of abundance of their now supplements. Right. And information. Right. That's why again even though originally let's say years ago when I was early in my practice like almost 16 years ago it was really I was explaining people and they were like what are you talking about? I never heard of it. They would kind of like thought they were kind of like an experiment. Right. But right now creating you know which was typically again more guys and who are really trying to kind of lift heavy now I'm saying no it's actually for them and it's actually from brain. It's actually totally not what you think it is for. So now it's people come to me can I take it? Should I take it? So it's different and they get it and they come to me and give me their pictures of the things they have in the home. Sometimes they have a couple, the cabin is full of things. I'm like, why in the world you would put it all together? Right. So it's really kind of the other side of their problem when it's actually we have so much and we are just sometimes putting ourselves into self created protocols which alone could be dangerous. Plus again, not all supplements created equal. I mean in our case like yours and mine, like you know, you overall get what you think so far anyway, it's the best. This already fails us. Right. So definitely everything else is just not even talk talkable. Right. So again, do your best basically. But overall in all other ways you should. We should understand we always and all of us are. Have so many things in terms of toxins totally out of control. So that's when you. Every day you should be doing something to detox yourself. Yeah, every day. Because it's, it's just in our modern world we are exposed to so many different things that are not even like known yet to be a toxin, let's say.
- [52:20]
A
Right.
- [52:20]
C
Are. So it's just really detox is one of the things that should be part of your protocol you're doing.
- [52:27]
A
So listen, this is a, it's a great conversation and to be honest we can go for hours. However, shout out to Chelsea, the producer, she made some rapid fire questions for us.
- [52:39]
C
Okay.
- [52:39]
A
So I want to make sure we go through them, but it does connect to what you just said. I'll even make one before, before we get to hers. But what is a, a detox type solution treatment, whatever you want to call it, fad that you wished people stayed away from. Maybe it's dangerous, maybe it's just fake and, and taking advantage of people.
- [53:07]
C
I mean it's a tricky one I would say doing detox just by juicing. Right. So I mean there is a part of it that's good but overall you need protein to detox. Right. You cannot detox juices for two weeks and actually it impairs your detoxification process. So you can do it here and there. You can do just better to do green juice part of your daily detox routine. Right. But not to do lengthy green juice detoxification plans because overall you're not really helping. Again, little, I would say at most five days, you know.
- [53:45]
A
Yeah.
- [53:46]
C
Of the just kind of the green juice or smoothies stuff if you. It means because some people would go for it and not have a protein of any kind.
- [53:56]
A
Yeah. Wow. Yeah. Yeah, that's true. They're, you know. That's, that's so true. Okay, what's one thing that's aging your skin faster than the sun and you don't even know it's in your home? Well, that's a detailed rapid fire there. Okay.
- [54:14]
C
I mean, I would say, I mean your nose in your home, it's a sugar, right? Nothing really inflames and notorious collagen production and overall 100 is because. Yeah, it's just meta inflammation and everything.
- [54:26]
A
Amen. Okay, what's one in air quotes? Clean beauty product people swear by that actually blocks detox. Detox. I need to think about that too.
- [54:38]
C
I don't know Blocks detox. Not sure.
- [54:44]
A
Yeah, I don't know about blocks detox. Obviously. I, I, I hate skin applied ascorbic acid as opposed to other vitamin Cs.
- [54:54]
C
Right, right, right.
- [54:54]
A
So I'll give that as an example. But I don't know about blocks.
- [54:58]
C
Yeah, I'm not sure. I'm sorry.
- [54:59]
A
Okay, that's fine. Next, if someone's using retinol but not addressing inflammation, what's actually happening to their skin?
- [55:07]
C
I mean, overall, you just aggravating whatever is going on because it just makes the whole inflammation times 10.
- [55:15]
A
Yes. Okay, what's on one IV therapy ingredient that gives skin glow without anything else. I changed that question.
- [55:26]
C
I would definitely say glutathione.
- [55:28]
A
Okay. Glutathione.
- [55:29]
C
Glutathione is the huge one. I mean I remember originally I didn't realize until I have people doing chelation therapy, you know, like removing the toxins and usually glutathione is a big part of it. And the patient was like, what are we doing for my skin? I'm like, nothing. She's like, no, we're doing something. My skin never been so good. And then I figured. And then obviously it's been more studies and yeah, so is the go to for support because it's our really powerhouse in the best defense mechanism for inflammation, oxidation and mitochondrial support. So I mean no wonder. But it's always the safest, the quickest and always works like a magic.
- [56:05]
A
Right. Love it. Okay, what's the most expensive skincare mistake you see in your clinic every single.
- [56:12]
C
Week is first of all are skipping their home care routine because let's say people go for crazy, literally amazing treatments, they spend thousands of dollars and they think that's pretty much it. Right. But it's what you do beyond that is actually going to either make it effective, like 20% or 200%. So definitely home care is there is the core and yeah if anything addressing obviously also internal stand but home care, it's all of it.
- [56:44]
A
So funny story. When I was extremely young, when I was, I don't know, 20 years old, I dated a famous model and that's the end of the story. No, I'm kidding. I dated a famous model that ate very poorly and would go constantly to do liposuction. And she was also 20. I mean I don't know how old she was. I don't remember. Maybe she was 19, maybe 21.
- [57:10]
C
Yeah, let's see. But I like. Yeah.
- [57:11]
A
Not. Yeah. So this is, this is like to me the most unhealthy example. Right. It's insane that there, there is this paradigm that we can go and kind of hard core treat something and then we're allowed to go ahead and you know, basically live off of donuts or, or something like that.
- [57:32]
C
No, but that's actually, I mean very extreme. But it. Besides the fact that it's a really like quick fix but it's very hard on your body, you're going to take so long to recover. Plus beyond even anesthesia itself the damages your brain. It's like proven right. It's overall like such a kind of process to forward to one liposuction. It's their intervention as your body is really kind of. It's really aging you just alone. Any surgery ages you because 100.
- [58:01]
A
Okay, fantastic. I love that answer. What's one lab marker that predicts skin aging before fine lines show up?
- [58:10]
C
I mean there's. I would say no one. If I would have to pick, let's say three. Right. CRP. CRP is inflammation marker. Right?
- [58:18]
A
Yes.
- [58:19]
C
And. Or A1C. I mean the sugar. And the third one I would say would be DHEA. Right. Which is more hormones. And if again we are. The levels are lower than for age. It's age specific. Right. So we have specific good kind of optimal numbers for every five pretty much at least 10 kind of decayed of the age. So that definitely our means of all our hormone health is actually slacking. And it would affect again because you said testosterone definitely going to be affected. The BHA is low and overall for women is going to be just in general like speedy aging.
- [58:53]
A
Love it. What's one?
- [58:55]
C
If you have let's say access to like more advanced tests. There is a true diagnostic, you know, true age test when you can actually check it's not one marker, it's like 200 markers. But it's more Giving you actually how your skin ages.
- [59:09]
A
Fun story about True Diagnostic and what we do. So we almost got into. Got in bed with True Diagnostic because we've developed a metabolomics test. We did it with a company called Theriom. Their metabolomics test is called Shout out to Therium. Their metabolomics test is called Aristotle. And we've developed a test with them to check metabolomes that are. That are related to skin aging and obviously how we change them with topicals, with supplements, things like that. But yeah, that's coming. You know, that's, you know, if you want to spend 900, a thousand dollars to check what you can do to improve your skin, there are those things too, right?
- [59:53]
C
No, but actually, this is a good idea. I would love if you guys would provide, let's say, let's say baseline skin age test. I don't know how to check, like, the scrap of it. I don't know what would be the way. Right. And then you use your products, and then we do it.
- [60:09]
A
We do it. And I think. So what we try to do is to provide extra value. Because at the end of the day, quite honestly, I am uncomfortable with asking you to pay. You know, there is no price that we've set yet, but let's say $900 for a test and then turn around and say, the way that you act on that test is also to pay me money for my product. What we could do is to say, this is how basically, what is a metabolomic test? It deciphers how your cells provide or process nutrients, how much nutrient that do they have? And also how do they process it in order to then act more youthfully? So basically it deciphers their youthful function. So we do provide a score that relates to skin aging. We do. Even though it's a dry blood. Blood spot, like you prick your finger, you touch the. Yeah. So then, yeah, we tell you, hey, these are the products are going to help you. But also you could do these other strategies, and it's only through providers, because the idea is not. If we did it, you know, online, we cannot recommend what you should do in other cases. And it will be really to sell products. So the idea is not really to sell products, is to empower the practitioner.
- [61:26]
C
You know, even though, yeah, obviously I can imagine it's not gonna be like 20 bucks.
- [61:31]
A
Yes.
- [61:31]
C
But you know what? For some people, like, I love science, right. And again, for many of my patients, it just, as you said, motivational. Right. You'll be like, no, my skin is good. And like, you know, they go to plastic surgery and then they're like, what really do we do to make it more glowy? Right. But it's really drives and then it's more like a game, like a sports. You know, let's see what's gonna be, I'm gonna do it. And then they more religious about doing their treatment in interventions. That's why typically, obviously not everybody will decide to do it. But you're gonna find, especially in these days when people are like biohackers and everybody who is like really into this, they want numbers, they want not just like young goose. Yeah. And I see this like, yeah, it sounds cool because it's metal and blue is because everybody talks about. I wasn't this for your company's shoe? Because I've been doing an ad, you know, years before you guys, at least I learned about you. I mean, I've seen you through other biohackers.
- [62:26]
A
Yeah.
- [62:26]
C
But I'm like, come on, you know, now you put in this nad on your skin, you know how it's gonna work, right?
- [62:31]
A
Yeah.
- [62:31]
C
But then I figured, like, you are not just superficial company who just again, trying to be transy and get people who just whatever, getting anything that's trendy. That's why I was like, you know what? I have to have it in my practices and use it personally. So, yeah, I will still, you're going to have a decent amount of people who would be willing. And again, it's going to be even more encouraging for them to stick to their protocols.
- [62:54]
A
Exactly. Yeah, I agree. And again, it's, It's. If anyone's, you know, just for those. Because I think, you know, we. I do want to address this. Like, if anyone is saying right now, oh my God, Amitai is telling me that I now need to spend another $900 every six months. I'm not telling you that. Okay, this podcast is for free, right? This podcast we talked about today, about things that you can do that actionable today. However, however, in order to allow this free conversation and to give, I would say, like the most up to date free recommendation, we need to explore the entire spectrum. And most of the kind of the bleeding edge part of the spectrum is very expensive. That's the truth. Anyway, next. This is the least fire, rapid, rapid, rapid fire questions I've ever had in my life. Okay, let's. What's one healthy habit that might secretly be inflaming your skin?
- [63:52]
C
I mean, I mean, going back to sugar, it's literally if it's dietary, if you're talking about any lifestyle. I would say sleep wise. I mean if you're not sleeping in the right hours in the right amount, that's just screwing up the whole system. So in terms of food. Yeah. Sugar and in terms of overall lifestyle.
- [64:11]
A
But let me, let me, let me, let me point you in a direction. What is something people literally doing? They're thinking it's healthy. Like they're doing it as a healthy stack. But really is aging them, aging their skin, aging them. What do you think.
- [64:29]
C
They believe it's actual health?
- [64:31]
A
Maybe eating tuna out of a can.
- [64:33]
C
I mean. Yeah. In terms of vaccines. No. Right, right. One of those. Obviously that's going up you. It's a food supply. Right. And the current situation with the seafood in general. Right. Is besides mercury, it's arsenic.
- [64:46]
A
Yeah.
- [64:46]
C
And even though you would think, you know again there is not all fishes better. It's just literally certain ones, certain kinds. You know, because you people trying to eat health as you said, increasing omega levels which are amazing for skin inflammation and overall for skin health. But they could be the source of mercury and arsenic that are worse effects of the opposite toxication. Right?
- [65:10]
A
Yeah. Yeah, yeah. Okay, let's do one more. What's a common toxin? You test for that. Almost everyone has and nobody realizes it or not. A lot of people realize.
- [65:23]
C
I mean it's not a very. I mean a lot of people basically I would say the phthalates and other more PBCs. Whatever is related to plastic.
- [65:32]
A
Right.
- [65:32]
C
I mean it's there. It just nobody tested it because it's a little extra. It's urine test. It's like you have to the specialty labs. But it's just a question of how toxic you are. It's not like if you are toxic with those plastic related cycles. Right.
- [65:46]
A
Have you seen that there's now a probiotic that's supposed to like help you detox from plastics. Have you seen that? I got targeted?
- [65:52]
C
No, I haven't.
- [65:55]
A
Next time I get targeted by this ad, I'll send it to you.
- [65:57]
C
Yes. Oh my God. No, no, absolutely.
- [66:01]
A
Okay, listen Marina, this has been fantastic. I really appreciate the time that you've spent with us. And let's talk a little bit about how do people work with you? How can they reach out? How do you work normally?
- [66:15]
C
Yeah. So my practice is located in Brooklyn, New York. But overall I do offer also teleconsultations. Right. So then it's just going to be a few tests that you will be going. I'll send you where to go for the blood work. And other like body composition tests Overall actually in terms of free stuff. Right. I'm very excited to announce actually this is the first place I'm kind of sharing this news. I'm an author. My book is coming out this month.
- [66:42]
A
Wow.
- [66:42]
C
The book is Harmonious Healing Blueprint. It's about biohacking, it's about regeneration and health resilience. It. It really gives you an idea to be like an advocate for your own health. What blood work to do. It gives a lot of information again tips like what to do for your energy, you know, in terms of supplements, nutrients, food. Really like our like blueprint for that beauty. Beauty, beauty, aging and energy. Kind of three of those things are in there and just overall a lot of information on all aspects from there standpoint of experience and they're in the most innovative things are mentioned there. So. And actually your brand too. So I will have to give you probably the page number where you are. Yes, located obviously you are on their beauty recommendations. One of the things you can do intervention wise because yeah he's personally I've been using your branded things from like either January, like literally slightly under a year. I mean it's impressive. You know, even though again I had a lot of skepticism about this and the kind of using just trending nutrients for topical things like this. You know, you would think as well as you said putting vitamin C versus eating it or like you know, if it's how you're actually gonna make it work for the skin, not just whatever kind of making it fun. So overall in terms of consultations I do offer. Yeah in person or our telecom version and I see children, adults, families. So you can find my website, I guess you're going to provide it and.
- [68:17]
A
We'Ll provide it in links, Instagram, things like that. However, this podcast is probably going to come out after your book is coming out. So we're going to make sure to add a link to the book on Amazon.
- [68:31]
C
Right.
- [68:32]
A
On Amazon. So that's going to be in the show notes. Is there a name for the book?
- [68:37]
C
Harmonious Healing Blueprint.
- [68:39]
A
Harmonious Healing Blueprint on Amazon. You can always obviously look for it on Amazon. Marina, thank you very much. It was such a pleasure.
- [68:46]
C
Thank you. I love that. Thank you. Such a pleasure.
- [68:49]
A
All right, thank you everyone. Bye bye.
- [69:04]
C
Sa.