Most Body Creams Are Marketing Hype and Here’s What Actually Works

Summary

Biohacking Beauty: The Anti-Aging Skincare Podcast

Episode: Most Body Creams Are Marketing Hype and Here’s What Actually Works
Release Date: July 30, 2025
Hosts: Amitay Eshel & Anastasia Khadrava

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Introduction to the Myth of Miracle Body Creams

In the episode titled "Most Body Creams Are Marketing Hype and Here’s What Actually Works," hosts Amitay Eshel and Anastasia Khadrava delve into the burgeoning market of anti-aging body creams. They question the efficacy of popular ingredients touted by these products and explore what truly contributes to youthful, firm skin.

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The Trendy Trio: Retinol, Glycolic Acid, and Hyaluronic Acid

1. Retinol: Retinol is often hailed as the gold standard for anti-aging, predominantly in facial skincare. However, its application on the body poses challenges.

• Efficacy Concerns:
  “Body skin is thicker and has slower turnover compared to facial skin. So in theory, it actually needs a higher concentration of retinol to get any kind of meaningful anti-aging effect.”
  (02:43)

• Risks of Overuse:
  High concentrations necessary for body skin can lead to skin barrier damage, causing dryness, flaking, and inflammation.
  “...you're really risking barrier damage. The skin starts to dry out, to flake, to get inflamed.”
  (03:23)

2. Glycolic Acid and Alpha Hydroxy Acids (AHAs): Glycolic acid is celebrated for improving skin elasticity and stimulating collagen but comes with its own set of issues.

• Benefits:
  “Glycolic acid actually goes deeper than most people realize. It has been shown to improve elasticity and even stimulate collagen.”
  (05:17)

• Drawbacks:
  Increased cellular turnover without proper support can accelerate aging.
  “This constant stimulation without recovery can actually accelerate aging.”
  (06:13)

3. Hyaluronic Acid: Hyaluronic acid is lauded for its hydrating properties but falls short in delivering long-term anti-aging benefits.

• Temporary Hydration:
  “Hyaluronic acid helps skin hold water, which makes it look plumper, but it just temporarily. So like few hours max.”
  (08:17)

• Limited Long-Term Impact:
  While beneficial for skin barrier support, hyaluronic acid doesn't address deeper cellular issues.
  “Hydration does not equal firmness.”
  (10:35)

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Understanding the Differences Between Facial and Body Skin

A significant portion of the discussion highlights why facial skincare routines don't seamlessly translate to the body.

• Thickness and Cellular Turnover:
  “The dermis on the body is significantly thicker... making it harder for ingredients to penetrate and actually create change below the surface.”
  (11:52)
  Additionally, body skin has slower cellular turnover, necessitating a different approach to anti-aging.
  “Cellular turnover... is much slower than on the face.”
  (12:09)

• Sebaceous Glands and Barrier Health:
  The body has fewer sebaceous glands, making it more prone to dryness and barrier damage, especially when using harsh active ingredients.
  “You need to make sure if you do use those products, you also have protective measures.”
  (12:45)

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The Impact of GLP-1 Agonists on Skin Health

The hosts introduce a contemporary factor affecting skin health: the widespread use of GLP-1 agonists like Ozempic.

• Prevalence and Effects:
  “20% of the American population right now is on a GLP1 agonist.”
  (36:42)
  These medications can lead to muscle mass depletion (sarcopenia) and nutrient absorption issues, exacerbating skin aging and firmness.

• Structural Skin Changes:
  GLP-1 agonists contribute to structural changes under the skin, necessitating more comprehensive skincare strategies beyond basic hydration.
  “These are structural changes... and they need a repair strategy that goes way beyond surface level hydration.”
  (15:44)

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Beyond Surface-Level Ingredients: Effective Skincare Strategies

To achieve genuine anti-aging results, the hosts advocate for a holistic approach that supports the skin's biology at a cellular level.

1. Cellular Support and Longevity Molecules:

• NAD Precursors:
  “NAD is the currency for repair in every cell in your body. It's responsible for 600 different types of processes that are linked with youthfulness.”
  (25:08)
  Boosting NAD levels supports cellular repair and energy production.

• Spermidine:
  This longevity molecule activates autophagy, the body's natural cleanup system, facilitating the removal of damaged cells and promoting new, healthy cell growth.
  “Spermidine... activates autophagy, which is your skin's natural cleanup, recycling systems.”
  (27:03)

2. Advanced Peptides:

• Lipopeptides:
  Specifically designed peptides like Caproil Tetrapeptide 3 and Palmitoyl Hexapeptate 12 enhance collagen and elastin synthesis, directly targeting skin firmness and elasticity.
  “They penetrate deeply and stimulate collagen, elastin, and even hyaluronic acid synthesis.”
  (29:25)

3. Mitochondrial Antioxidants:

• Ergothioneine:
  Derived from mushrooms, this potent antioxidant protects skin mitochondria from oxidative stress and supports glutathione recycling, enhancing the skin's repair mechanisms.
  “Ergothioneine... is an incredible mitochondrial antioxidant.”
  (31:00)

4. Rare Longevity Mushrooms:

• Tricholoma Matsutake:
  Rich in beta-glucans and antioxidants, these mushrooms target DNA repair and reduce inflammation, contributing to structural skin regeneration.
  “They're rich in beta-glucans and antioxidants that target DNA and help with photo-aging.”
  (34:43)

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Comprehensive Skincare: Integrating Internal and External Support

The episode emphasizes that effective skincare is not solely about topical applications but also involves internal support through proper nutrition and supplementation.

• Protein Intake and Weightlifting:
  Maintaining muscle mass through protein intake and resistance training is crucial for skin firmness, especially when on medications like GLP-1 agonists.
  “You really want to make sure you're eating enough protein and... lifting heavy weight to maintain the form of the way your skin is draped on your body.”
  (36:54)

• Microneedling and Professional Treatments:
  Advanced treatments like microneedling can be beneficial but should be performed by professionals who understand the importance of supporting the skin's recovery processes.
  “Microneedling... should be done especially in the body with a professional that really understands the recovery portion.”
  (38:03)

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Conclusion and Key Takeaways

Amitay and Anastasia conclude by reiterating the importance of addressing skin aging from a cellular perspective rather than relying solely on trendy topical ingredients. They advocate for a comprehensive approach that includes:

• Supporting Cellular Repair and Energy Production: Utilizing ingredients like NAD precursors and spermidine.
• Enhancing Collagen and Elastin Synthesis: Through advanced peptides such as lipopeptides.
• Protecting Against Oxidative Stress: With mitochondrial antioxidants like ergothioneine.
• Incorporating Functional Ingredients: Such as rare longevity mushrooms for DNA repair and inflammation reduction.
• Adopting a Holistic Lifestyle: Ensuring adequate nutrition, protein intake, and physical activity to support skin health internally.

“Instead of just throwing hydration or exfoliation at a problem, we are targeting real drivers of youthful skin energy production, protein synthesis, cellular recycling and cleanup, and very important, barrier strength.”
(39:43)

By focusing on these deeper, biologically-driven strategies, the hosts emphasize that achieving and maintaining youthful, firm skin requires more than just surface-level solutions.

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Notable Quotes with Timestamps

• “Body skin is thicker and has slower turnover compared to facial skin. So in theory, it actually needs a higher concentration of retinol to get any kind of meaningful anti-aging effect.”
  — Amitay Eshel (02:43)

• “Hydration does not equal firmness.”
  — Anastasia Khadrava (10:39)

• “20% of the American population right now is on a GLP1 agonist.”
  — Anastasia Khadrava (36:42)

• “NAD is the currency for repair in every cell in your body. It's responsible for 600 different types of processes that are linked with youthfulness.”
  — Amitay Eshel (25:08)

• “Instead of just throwing hydration or exfoliation at a problem, we are targeting real drivers of youthful skin energy production, protein synthesis, cellular recycling and cleanup, and very important, barrier strength.”
  — Amitay Eshel (39:43)

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By critically evaluating the effectiveness of popular body cream ingredients and advocating for a science-backed, cellular approach to skincare, Amitay and Anastasia provide listeners with valuable insights into achieving genuine anti-aging results. This episode serves as a guide for those seeking to move beyond marketing hype and invest in truly transformative skincare solutions.

Transcript

[Amitay Eshel]

Welcome back to Biohacking Beauty, the podcast where we decode the science of aging and skincare to help you look and feel your best, starting at the cellular level. I'm Amitay Eshel.

[Anastasia Khadrava]

And I'm Anastasia Khadrava. And today we're talking about something we've been seeing everywhere. Anti aging body creams.

[Amitay Eshel]

Seriously, it's becoming kind of a thing. Retinol for your thighs, glycolic acid for your arms, hyaluronic acid for your chest. People are applying their basically their facial routine to their whole body now.

[Anastasia Khadrava]

Yeah, it's like your skincare routine just expanded from a few steps at the sink to a full body commitment after the shower. And brands are totally jumping on board. Their products everywhere promising smoother, brighter, tighter skin from head to toe.

[Amitay Eshel]

But we have to ask the question, do these body creams actually work? What actually does it mean to work? Or are we just buying really expensive body moisturizers with a few buzzy ingredients?

[Anastasia Khadrava]

Exactly. Because your body skin is not the same as your facial skin. And slapping a little retinol on your arms might not give you the results you're hoping for or you're marketed.

[Amitay Eshel]

So, yeah, so in this episode we're breaking it all down. What's really inside these trending products, how they're marketed and whether they're doing anything beyond just hydrating.

[Anastasia Khadrava]

Plus we'll talk about why your body's skin is actually different, why it needs different approach if you're trying to get real anti aging results.

[Amitay Eshel]

So if your bathroom is slowly turning into a body care aisle and you're still wondering why your skin doesn't look firm, firmer or more toned, this one's for you.

[Anastasia Khadrava]

Let's get into it.

[Amitay Eshel]

All right, so let's talk about these so called miracle body creams. What are people actually reaching for? You know, right now?

[Anastasia Khadrava]

Honestly, it's the same lineup we've seen in facial skincare. Retinol, glycolic acid, hyaluronic acid. But now they're in these big body cream bottles, often with words like firming and tightening.

[Amitay Eshel]

Yeah, right. And let's start with the, I think the big one, retinol. Everyone thinks it's kind of the golden standard for anti aging. And to be fair, it is great. But mainly on the face, in the right concentration too and with the right support or the right kind of complex around it.

[Anastasia Khadrava]

Yeah, totally. So here's the thing. Body skin is thicker and has slower turnover compared to facial skin. So. So in theory, it actually needs a higher concentration of retinol to get any kind of meaningful anti aging effect.

[Amitay Eshel]

Yeah, but the problem is since once you start going higher with retinol, especially over larger, larger areas like thighs, arms, chest, belly, et cetera, you're really risking barrier damage. The skin starts to dry out, to flake, to get inflamed. It's called actually retinization and it's not sustainable.

[Anastasia Khadrava]

Exactly. So that's why people actually get frustrated with retinal body creams and actually face creams as well. But we're talking about body right now, so they're not seeing results. And the results that they do see is basically irritated, compromised skin when they do it improperly. So they, they overdo it and then they end up with, you know, disrupted skin microbiome, flaky skin, compromised skin barrier.

[Amitay Eshel]

Or the, the percentage just very low. And actually there is, there is not, there's not much results that's being driven now. So yeah, if you're using retinol without the right barrier support, both in the face, but mainly in the body, or without anything that promotes active repair, for example, which we're going to talk about, you're just setting yourself up for irritation, dryness and flaking, which, spoiler alert, doesn't exactly equal firm, glowing skin.

[Anastasia Khadrava]

No, no. And yet people just end up walking around with, you know, this really dry, ashy kind of looking skin. And they, they're just confused because they're like, I'm moisturizing and I'm doing all that skincare. What's going on? Why is my skin so dry after me investing in all those lotions?

[Amitay Eshel]

Yeah, right. Okay, let's move on to glycolic acid and other alpha hydroxy acid AHAs. These seem to me that are, they're also super trendy in body lotions right now. And it kind of, I think leapfrogged the, their intended use in body products which would be for, to correct kind of coarse skin or different types of like calcium deposits around, around hair follicles which, which do. They do have their place, but I think they now kind of kind of invade the firming or kind of body skin anti aging category.

[Anastasia Khadrava]

Yeah, for sure. And I actually heard anecdotally a lot of good results for scalp treatments for people that, you know, need that support there. And yeah, I think, I think that the manufacturers of glycolic acid, they're having like really good time. You know, they, they sold lots of it for face creams and now that it's like dying off and it's not as Trendy, not as hot. Then it became scalp treatment, you know, focus. And now they're, they're selling even more of it for body cream because it's like larger sizes, but in any. Anywho. So why glycolic acid? The glycolic acid actually goes deeper than most people realize. It has been shown to improve elasticity and even stimulate collagen. But it comes at a cost. It increases cellular turnover, which raises your skin's energy demand.

[Amitay Eshel]

Yeah. So you're basically saying that the main goal is to push the skin to regenerate more frequently. That sounds like a good thing. What's the problem here?

[Anastasia Khadrava]

Yes, but when you think about the whole physiology and biology of your skin, if you're not using longevity molecules like NAD precursors or anything that supports mitochondrial energy and repair, the skin can't keep up. So over time, this constant stimulation without recovery can actually accelerate aging. Similarly. How, you know, hopefully most people know with everything else that you do for your body workout or you know.

[Amitay Eshel]

Yeah, I think, you know, and that kind of correlates with, with the way that we formulated facial products. It's one of those tools that can be very powerful but can also be overused and become risky if you're not supporting, first of all, if you're using it kind of at home, this should be something that's used by professionals. And if you're not supporting the biology underneath, it could kind of. It could kind of.

[Anastasia Khadrava]

Exactly. Yeah, yeah. No, and that's also like you said, we make like not over the counter. We make professional glycolic products that are only in use in office with professionals, highly trained, you know, because it could be good. You just need to know, you know, how to dose it and how to support just like you said. So for the body cream though, for the body care, we use glycolic acid. It's from just regular over the counter body cream. You will get short term results like smoother texture or glow. But if you keep using it without real cellular support, you're basically overdrawing from your skin's repair bank.

[Amitay Eshel]

All right, I got it. Okay, last one. I think from the. Let's slap that on the label and see the money rolling in. Is hyaluronic acid. Yeah, I think hyaluronic acid is probably like, I think probably next year people are going to start calling their kids hyaluronic acid. So it's really in everything. What's the deal with hyaluronic acid and especially like in body care, you know.

[Anastasia Khadrava]

I think next year the bottle, the bottles of water will be hyaluronic acid.

[Amitay Eshel]

Wow. They will. It's not, by the way. It's don't, you know, don't, don't underestimate oral hyaluronic acid. The problem is it can make your tummy sensitive. Yeah.

[Anastasia Khadrava]

Anyway, I actually remember when you had the podcast with Emmy Killer and you guys talked all about oral hyaluronic acid supplementation, which overall we support. But again, you have to do it well.

[Amitay Eshel]

Yeah.

[Anastasia Khadrava]

So hyaluronic acid is all about hydration. It helps skin hold water, which makes it look plumper, but it just temporarily. So like few hours max. When you talk about body cream or facial care as well, if, if you hear ingredients hyaluronic acid, it's literally nothing. It will do nothing except plump your skin for like an hour. Top.

[Amitay Eshel]

Yes. I think a lot of people ascribe traits to hyaluronic acid that are not there, but they're also ignoring the benefits of hyaluronic acid, which are skin barrier benefits rather than something on a cellular level that goes into your cells and correct some underlying condition, underlying problem.

[Anastasia Khadrava]

But I personally think if you're already looking to use hyaluronic acid for barrier support, there are better things for barrier support there. You can improve your skin microbiome with different kind of like prebiotics, probiotics already exist, you know, for your skin. And you can also invest in something like biomimetic lipids, which will be the glycolipids, phospholipids, identically to your skin barrier. And that's really going to repair your skin barrier. Hyaluronic acid. That's, that's the best that it can do for you. But is this the best choice? I don't think so.

[Amitay Eshel]

I think it has a place in formulation. I think it, it allows for a water based product that supports skin barrier to some extent. I mean it could be one of the ingredients that supports skin barrier where a product needs to be based on water rather than on lipids.

[Anastasia Khadrava]

Yeah.

[Amitay Eshel]

Having said that. Yeah. I think again, I think we're saying kind of the same thing where that's not something you should be looking for in your skin care.

[Anastasia Khadrava]

Yeah, that's what I was referring to as a hero ingredient. I think you can do much better. But I agree with you. As one of the supportive ingredients, hyaluronic acid definitely has its plate in, you know, water soluble products.

[Amitay Eshel]

Yeah, absolutely. And I think the bottom line is it's not really changing anything long term.

[Anastasia Khadrava]

Yeah. So let's be clear, hydration does not equal firmness.

[Amitay Eshel]

Yeah.

[Anastasia Khadrava]

And yeah, I mean if hyaluronic acid could tighten your face significantly, your neck, your thighs, everybody would have already done it and we would all know about it. It just doesn't do it.

[Amitay Eshel]

Yeah. I think the takeaway is. Yes. These in the, the ingredients that we mentioned, retinol, hyaluronic acid. Aha. Glycolic acid. Namely they can improve your, the, the look of your skin or the feel. The feel feel of your skin. Short term you might get smoother texture, a little more glow softer skin. Short term.

[Anastasia Khadrava]

Yeah, but they're not reversing aging on their own. For long term firmness, density and true regeneration, you need to go deeper and you need to support the skin's biology, not just, you know, use trendy ingredients for like surface hydration.

[Amitay Eshel]

Yeah. So now that we've covered what these, you know, what the kind of trendy body creams actually do or not do, let's talk about why your body's skin needs a different approach. I don't know if to say like completely different approach, but a different approach than your face.

[Anastasia Khadrava]

Yeah. And as we alluded before, it starts with biology. So the dermis on the body is significantly thicker in most areas, as especially on the thighs, stomach and upper arms. That makes it harder for ingredients to penetrate and actually create change below the surface.

[Amitay Eshel]

And that's not the only difference. I feel like there is also the issue of cellular turnover on the body, which is much slower than on the face. So cellular turnover. In other words, this is the rate of renewal. So even when you're you using the right actives, your skin is responding more gradually and it needs more recovery time or the, the function of recovery needs to be more robust in the supportive. The, the, the what how we fuel support needs to be a bigger part of the overall process.

[Anastasia Khadrava]

Exactly. And let's not forget about oil production. The face has far more sebaceous glands which helps protect and moisturize the skin. Naturally. The body has fewer of those, especially in the areas like arms and legs. So it's more prone to dryness barrier damage, especially when people start using all those harsh ingredients. We talked about retinol AHAs. You know, I'm, I'm excluding obviously hyaluronic acid from that. So yeah, you, you need to make sure if you do use those products, you also have protective measures.

[Amitay Eshel]

And that's when we hear, especially from people who are very interested in the firmness of their skin as, you know, as they grow older, that's when we start hearing things like my skin feels dry or itchy or I'm flaking even though I'm moisturizing. Really it's because these active ingredients are stressing the skin and the body doesn't have the same built in, built in tools to bounce back or to respond to that stimulation.

[Anastasia Khadrava]

Yes. So that those a lot of the times were like some sort of internal processes, but they're also external stressors. So think sun exposure, hormonal shifts, which are basically internal weight changes. They all show up more dramatically on the body. We're talking about loss of elasticity, stretch marks, crepey texture people complain about. And that's basically the number one complaint I feel like when it comes to, you know, neck and chest, body, arm and the, you know, stomach as well. And so these, these are the reasons people start to feel self conscious about the way their body skin looks. And then obviously, you know, it makes you feel really bad.

[Amitay Eshel]

And I think now the, the addition of GLP1s to the conversation, I think that's a big factor. Whether it, it is sarcopenia inducing, whether it is, in other words, whether it is depleting muscle mass which would lead to less firm skin in the body or, or not, or just depriving you of nutrients which would make skin quality decline in both of those areas. I feel like that's just another player that has changed the way that people's skin looks, especially in the body. Also in the face. Obviously there is the big discussion around ozempic face, but there's also a discussion, yeah, there's also a discussion on ozempic butt. Anyway, but this is not something a basic moisturizer can fix. These are structural changes in the, you know, in the skin, under the skin. And they need a repair strategy that goes way beyond surface level hydration.

[Anastasia Khadrava]

Yeah, yeah. The body skin doesn't just need skin care in that sense that you just care for the surface layer of your skin. It needs actually cellular support because like you mentioned, it's all about skin integrity and makeup. And that really, really comes from within because none of the ingredients superficially can really go ahead and firm up your skin. Unless it comes from, you know, unless these are the instructions your body tells your body to do.

[Amitay Eshel]

Yeah, unfortunately a lot of these products on the market, they don't address that at all. The formulation is, you know, when you formulate a product, you don't actually start with, oh, this is a cool ingredient. I mean, for the most part, oh, this is a cool ingredient. I'm going to make a product around that or anything like that, you're like, okay, what do I want to focus on as the end result? And for 99% of the. 99.9% of the product, it is, you know, user experience. I want the user, after they put it, like, for the next hour, to feel like they have a smoother or more hydrated or softer skin. There's no cellular changes are irrelevant. I feel like when other people formulate.

[Anastasia Khadrava]

When we formulate.

[Amitay Eshel]

Yeah, yeah, yeah.

[Anastasia Khadrava]

But. But. And also, especially for the body cream, it is that moment of like, you think, you know, like, conventionally and marketing wise, when will a person use it right after shower. So it has to smell, smell good, look good, make the skin look glossy and shiny. You know, all like you said, and you're right, is if. If it feels good and there is immediate improvement in skin softness and appearance, most people will, you know, be hooked on this product for a little bit, unless. Until they see, okay, it doesn't actually help make creepiness of the skin. It actually, like, the results disappear within a couple of hours, and then the skin is back to being itchy and red, you know?

[Amitay Eshel]

Yeah. And I would say even. Even companies who, I feel like, do a better job with formulation for the. The real majority, what I see is the. Is they basically repurpose their face formulas, water them down a little bit because they need to be cheaper per gallon. Right. Per bottle, and sell them in a bigger bottle. That's why you water them down with it, you know, with an alternate label, like, you know, for the body or whatever.

[Anastasia Khadrava]

Totally. And honestly, the minute you. You mentioned, like, ozempic face as a ozempic butt, I. I just now drew the connection. Why There is, like, such a boom of body creams, and I think it's definitely connected. No, I know, but, you know, sometimes it's like we get. So I get it.

[Amitay Eshel]

Anastasia, you're saying, oh, I don't have ozempic face and ozempic butt. So, you know, ooh, I never thought about that. I get it. Okay. Yeah, but most people are listening to this podcast. Even people who are looking at the podcast. It's not like they can see their butt. So for the record, Anastasia doesn't have oic butt. Okay, guys.

[Anastasia Khadrava]

God. Yeah. But. But it's also. You have this, like, really, you can.

[Amitay Eshel]

For the record, you're not even on Ozempic. I don't know. Even.

[Anastasia Khadrava]

Yeah, Listen, guys, I mean, I don't know why it's such a big point to. To defend the natural. Natural but the. It is true that, you know, we live in like sometimes I, I think I stay in my own kind of bubble and I didn't. Don't even like draw this connection and you have like the broader look and you can see this type of trends and, I don't know, connect the dots.

[Amitay Eshel]

Hey there.

[C]

This is Amitai, co founder and CEO of Young Goose and host of the Biohacking Beauty podcast. I wanted to take a brief moment to share something really special with you, our dedicated listeners. At Young Goose. We've always been about more than just skincare. We are about cellular care. We believe in not just addressing the signs, but truly diving into the very source of skin aging. The reality is, as time goes on, our skin undergoes damage and this damage accumulates gradually leading to those signs of aging we all see and know very well. But what if we could hit the rewind button? What if we could delve deep, not into the layers of the skin, but into the life sustaining mechanisms of our skin cells? That's exactly what we're doing at Yungooks. We're pioneering a renaissance in skincare by employing principles from regenerative medicine. By rejuvenating and restoring the cellular flow functions, our products aim to rewind time, gifting your skin a youthful, vibrant glow. And for our Biohacking Beauty listeners, we have a special treat. Head over to Yongoos.com right now and use the code PODCAST10 to get 10% off your first purchase. Discover the magic of truly transformative skincare. And hey, because we value our research returning customers just as much, use podcast five on your subsequent purchases to get 5% off. And the best part, that this discount can be combined with subscriptions in our already discounted systems.

[Amitay Eshel]

So why wait?

[C]

Dive deep into the realm of regenerative skincare with Yungoos and let your skin. Thank you. Remember, it's not just skin care, it's cellular care. And now back to our conversation.

[Anastasia Khadrava]

Let's shift gears a little bit and we have very, very big news to announce. And that's not very easy. When I said big news, I thought about that. Well, since the moment we launched Care over five years ago, people have been asking us to make it for the body. And, and I quote, people would say I would just take a bath in the care moisturizer, you know, so the ask of creating a body product has always been there and we really took our time with R and D to to create something that not going to follow trends. We always set the trends. I. I know I'm tooting our own horn here, but that's just the reality. We brought NAD plus precursors to the market, we brought sperm with it, and we could have made already a lot of body creams if we. Our point was just to make one and sell one. But now I think we made really something special that I'm very proud of.

[Amitay Eshel]

So, you know, I think a lot of the times what I would like to do as a company as a whole is I get people into our head first, like decision making and stuff like that. So how about we start by talking about, like, what would work in, in, in a body cream, what would work on a cellular level? Maybe we'll start there.

[Anastasia Khadrava]

Absolutely. I mean, that's what we've been asking ourselves for the last, like four or five years. So we should definitely talk about it. So this is really where biohacking skincare shines. We're talking about body skin that's aging, sagging, or losing structure. So you need to go beyond non biohacking, beyond hydration and exfoliation, which is what the mass market tells you to do. So you need to restore, to restore your cellular energy, you need to support collagen production in a meaningful way from the inside, giving your body directions to, you know, go ahead and make collagen and protect your skin's internal system.

[Amitay Eshel]

Yeah, speaking about a system, one of the coolest things that we've done in the last few years is around NAD precursors. I think one of the most powerful tools that are available right now as a whole is our NAD apex or the NAD APEX complex. So I'll just maybe say a few words about it. So this is the second or third generation of how you boost NAD in the body. And it's a dual action. So it's first of all what people know to expect from us, which are liposomal micronized NAD precursors. We've narrowed. We basically have narrowed it down to using nmn. And we are now gradually introducing other precursors, but mainly nmn. And now we've matched it with NAD recycling enzymes that basically or N N a M P T is how your body is the enzyme that your body uses to recycle nad. And what we do, we kind of stimulate that, that enzyme to recycle more nad. So basically we refuel the skin from the inside. So NAD is the currency for repair in every cell in your body. It's responsible for 600 different type of processes that are linked with youthfulness repair, gene expression. Just basically the software that is the youth software of your body runs on nad.

[Anastasia Khadrava]

Yeah.

[Amitay Eshel]

And aside from that, it also helps increase something else that's called ATP. I'm sorry, for all the acronyms, but adenosine triphosphate, which is basically the energy in your skin, which gives the skin cells the energy they actually need to repair themselves. So you're running that youth software and you're giving the body the energy to repair itself.

[Anastasia Khadrava]

Yeah. And, I mean, there is. We can. We already had podcasts on NAD that are like an hour long, and we can go even longer.

[Amitay Eshel]

We can do it again once in a while.

[Anastasia Khadrava]

I think, also to just drive the point home. Like, if you don't have NAD in your body, suddenly, for whatever reason, you would die in 10 seconds. That's how vital this is.

[Amitay Eshel]

Yeah.

[Anastasia Khadrava]

And then also, just to understand, they.

[Amitay Eshel]

Should have, like, an X Men character that takes away NAD from people's mind.

[Anastasia Khadrava]

Yeah. And then also between the age 30 to 60 or 50, your. Your NAD plus level circulating and your body go down by half. So that, you know, for those of you listening and, you know, if you already closer to 50s and 60s, you know, now that you have half of the amount.

[Amitay Eshel]

So now you know why, you know.

[Anastasia Khadrava]

Yeah. And I mean, like, not have enough energy to repair something. That's how the damage accumulates. Also, NAD plus activates fibroblasts. So this, like, in the complex that we developed, the NAD plus apex, one of the really special outcomes is the activation of fibroblasts. These are the cells that are responsible for making collagen elastic. So you're not just masking aging. You're actually building structure back into the skin from the inside out. Plus, it reinforces the skin's resilience and helps restore vitality where it's been lost.

[Amitay Eshel]

Yeah. And I think although we. We've tooted the horn of nad, nad, apex, there is another ingredient that we love and that we brought to the market. That we brought to the market and in my opinion, is the most effective at creating visible change in skin tissue, which is called celvio spermidine, which is.

[Anastasia Khadrava]

Brought to the market of skincare to be.

[Amitay Eshel]

Yeah, yeah, yeah. We've developed it with the company that one of their members is the guy who won the Nobel Prize for autophagy.

[Anastasia Khadrava]

Yeah. Which their board member also, David Sinclair, wrote a very famous book.

[Amitay Eshel]

Yeah. So, yeah. It's a longevity molecule that activates autophagy, which is your skin's or your body's natural cleanup, recycling systems. It takes basically old damaged components like collagen, like elastin, like anything, really. Mitochondria and it clears out that those damaged components, by the way, including senescent cells. So and it, it can actually then use those components to build new, fresh components. That's why it's so cool. It's not only like taking out the old collagen, it can actually then use it as building blocks for newer collagen. If people take like collagen powder, right, and they think that is collagen that their skin is now going to receive. No, what it does, you know, best case scenario is the body then breaks down that collagen in your gut and has building blocks now to create collagen. So here you're doing it out of your own reservoir of old collagen, which I think is insane. And the same thing could be said for mitochondria for, you know, again, anything. So that healthier, you, more youthful, more functional, more youthfully functioning skin can then regenerate much faster.

[Anastasia Khadrava]

Yeah.

[Amitay Eshel]

Or much better.

[Anastasia Khadrava]

Yeah. I mean, honestly, I think you, you really did a great job summarizing why skin permidine doesn't just support cleanup, but actively rejuvenates and, you know, supports like real body care and the longevity aspect of it. So let's talk about another ingredient, something that maybe people never heard about. Lipopeptides specifically. I might. It's a tongue twister, so bear with me. Capriol Tetrapeptide 3 and Palmitoyl Hexapeptate 12. These are bioavailable peptides delivered through lipid carriers. So they penetrate deeply and stimulate collagen, elastin and even hyaluronic acid synthesis. So you make your own hyaluronic acid.

[Amitay Eshel]

So what? Do what? So maybe you should talk, maybe talk a little bit about what they do, what they target, what areas do they target, you know, specifically.

[Anastasia Khadrava]

Yeah, so they're incredible for targeting areas of laxity, like thighs, arms, or the stomach, because they help visibly tighten and tone the skin. And they also strengthen the skin hydration barrier, which is like we talked about for the body, since you don't have sebaceous glands. That's a, that's a huge miss. There's a huge issue.

[Amitay Eshel]

Yeah, great. Fantastic. I think, as we say, you know, many, many, many times, peptides are super tricky, super tricky to formulate with. Super tricky, super tricky. And another thing, super trick, super trick. Another thing is that they are not very normally, the skin barrier and the acid mantle is not very peptide friendly. So a lot of them just get damaged and broken and denatured, et cetera. By the time that they hopefully do absorb. And the cool thing about lipopeptides is that they are wrapped in this lipid membrane or they're interacting with lipids in a way where they can penetrate through those barriers that are lipid based much more easily. And the results are really cool. Having said that, I do want to talk a little bit about antioxidant. So we, we included ergothioneine, which I think is like the, the next hype again. Another molecule where we're starting with it. There is no, there is no patent around it by the way. You derive it from mushrooms. There's no pattern around it. We know other companies are going to follow suit. It's just that it is crazy expensive right now. But it's an incredible mitochondrial antioxidant. So it protects the skin from oxidative stress at its source, which is in the mitochondria and ones that are caused by pollution or UV exposure. And the really cool thing that it helped you recycle glutathione. So remember we said, I said that peptides are like really difficult to absorb. Glutathione, which is built of peptides built of proteins, is one of those things. Any way you spin doesn't absorb very well or you need to basically like create a system that kind of bursts through your skin barrier and it's going to damage it and stuff like that to get it absorbed through your skin. And the really cool about ergothioneine is that there's incredible data on its bioavailability topically. And it helps your body make glutathione, which is your body's master antioxidant. It comes with a cape and everything. It's a master.

[Anastasia Khadrava]

Yeah. So that's. No, it's funny. I immediately started talking about Halloween. Well, also ergothione.

[Amitay Eshel]

Yeah, this Halloween I'm dressing as ergothione.

[Anastasia Khadrava]

Well, and I'll be an easy plus again.

[Amitay Eshel]

So who's going to dress like spermidine? And why do I have a feeling that's going to be the most funny costume? Never mind. Okay. Yeah, go ahead.

[Anastasia Khadrava]

Okay. Argotinine we were talking about also supports DNA repair, which is crucial for long term skin vitality. It's one of the best ways to protect your investment in active skin care.

[Amitay Eshel]

Yeah, I think the combination of. So we've had this holy grail of like two ingredients which work like really well together. I would even say three ingredients. So in facial skincare we use resveratrol, fermented resveratrol, nad precursors and spermidine. And I think our understanding evolved in a way where we understand ergothioneine, because before beforehand I was referring to the youth software that your. That your cells run and that basically is your epigenetic expression or DNA expression. And the reason we now are obsessed with ergothioneine is because it supports that activity of NAD precursors where they go back to your DNA and make sure it function in a youthful fashion. Or again, that we're running a software of young skin. So I think it's a really cool addition to what we're doing. Speaking of mushrooms, one more unique active or actives that we use are a combination of Tricholoma matsutake mushrooms. So one is an extract and one is a ferment, which are a rare longevity mushroom. The reason is, is the reason is. The reason is, is that they're rich in beta glucans and antioxidants that again, target DNA. And they can help specifically with things like photo aging, inflammation or inflammaging and structural regeneration, which, which we've spoken about today.

[Anastasia Khadrava]

Yeah, and more, more than that. They're also incredibly soothing. And more. They're also incredibly soothing, especially for skin that's been stressed or compromised. And we talked about our body skin to be constantly bombarded with external stressors. So while the other actives are building and energizing, this one is like the calm reset button, keeping the skin calm, balanced and protected. So always about like the team, you know, so all of the ingredients, they have to be good team players and they have to make a good team.

[Amitay Eshel]

Yes, and I would say so we, we kind of mentioned also the GLP1 agonists, you know, WeGovy, Mounjaro, good job.

[Anastasia Khadrava]

You know them all.

[Amitay Eshel]

Ozempic, etc. Semi glutide.

[Anastasia Khadrava]

Not for my personal journey though.

[Amitay Eshel]

No, no. Anyway, but we mentioned those things. I just want to mention them because someone's going to say, but that's not the one I'm using. So. No. So all of the GLP1 GLP3 agonist, one of the things that they're doing, they're making it very hard for the body to absorb nutrients or they're making it more difficult. And there are two things that we've aimed to do with the body cream. So I think one thing that we should mention, if you are on one of those, you really want to make sure you're eating enough protein and, you know, lifting heavy weight, that's going to be the thing that's going to maintain the form of the way that your skin is draped on your body most effectively. Having said that, even if you do all of those, there are micronutrients, there are things that are derived from food, like things that we mentioned, like nad, like spermidine, like, you know, antioxidants, things like that that are now going to be less available. And when you grow older, as you say often, is that the skin is just not prioritized. So, you know, one of the things that we've done is we said the 20% of American population right now is on a GLP1 agonist.

[Anastasia Khadrava]

Wow.

[Amitay Eshel]

Yeah.

[Anastasia Khadrava]

Yeah, that's crazy.

[Amitay Eshel]

Yes. It's a new statistic that I've just learned, actually.

[Anastasia Khadrava]

Yeah. And like, when you talk to Dave Asprey, he often said, oh, I didn't know that. So that's my moment. Oh, I didn't know that.

[Amitay Eshel]

I have a feeling you know about skin way more than Dave Asprey. Shout out to Dave Asprey, though. He was very nice.

[Anastasia Khadrava]

Well, he was. He was great, honestly. And he. I love it how when you go to podcasts which you are requested to come and talk about skin health and explain about jangos, you. You basically talk about science and you, like, never really plug in our products. So then it becomes the job of the host to be like, okay, so what product do I use? So what should I apply first? How many times a day? Because, like, by yourself, you will never say that you're so nice about it. Like, you're, you're really not salesy. And I think that's really honorable thing. And that's why it's so pleasant to use to, to listen to your podcast appearances.

[Amitay Eshel]

Thank you very much. You are also great.

[Anastasia Khadrava]

Thank you.

[Amitay Eshel]

No, but what I want to say is that this product. So we know, we know you and I know that there is going to be an incredible. A crazy, crazy, crazy, crazy, crazy push for products that allegedly compensate for.

[Anastasia Khadrava]

Oh yeah, they're already there.

[Amitay Eshel]

They're already there. So, yeah, Image just launched the Volumift, which is.

[Anastasia Khadrava]

Yeah, so I did know about products. Remember how I said it in the beginning of this podcast? Like, I didn't connect the dots between the body care and the, the, you know, the drastic weight loss that this 20% that are on ozempic experiencing. I did know about facial products and also, like, there are so many modalities also like radio microneedling, radio frequency that promises to tighten your face after you lost facial volume. I just didn't think about the body.

[Amitay Eshel]

Yes, yes, yes. Product actually, by the way shout out to microneedling. This is something that again, should be done especially in the body with a professional that really understands that. But I think microneedling for the body when someone is interested in like firming the skin is something that could be.

[Anastasia Khadrava]

Very helpful, especially microneedling without radio, without radio frequency.

[Amitay Eshel]

Especially if you're talking about being special. No, especially if you're talking about the recovery. If you're good with the recovery portion. If you're, if you're using, you know, again, NAD precursors, things like that. But my point was these are not prioritized by the, by the body to go to the skin anyway, number one. Number two, if you're anyway in like caloric depletion or negative, basically in a negative caloric intake, they're going to be less available. They're going to be prioritized way less to the skin. They're going to be prioritized more to the vital organs. So this product is also for you. If you're on GLP1. This product is mandatory. Actually, it's. You can, you, you can straight to jail if you don't take this product straight to jail.

[Anastasia Khadrava]

But yeah, anyway, Parks and Recs, guys. This is from Parks and Recs. If you didn't watch this episode, you should.

[Amitay Eshel]

Yes, you should. So instead of, again, instead of just throwing hydration or exfoliation at a problem, we are targeting, I would say, like real drivers of youthful skin energy production, protein synthesis, cellular recycling and cleanup, and very important, barrier strength.

[Anastasia Khadrava]

Exactly. Because when you support your skin biology this way, the results go beyond what you can see. They're actually structural, which this is what we were saying is lacking on the market. So you're not just getting smoother skin topically, you're helping your skin function like a younger skin, which is the whole premise here at Young Goose in our labs. And that's really what we specialize in. We're making your skin function at a younger level, functionally. Younger skin function. Function now also for the body.

[Amitay Eshel]

Now for the body. And Anastasia, so because you're the special guest.

[Anastasia Khadrava]

Am I? I thought I graduated to the co host.

[Amitay Eshel]

I wish, I wish you would co host every episode.

[Anastasia Khadrava]

I already had a solo episode.

[Amitay Eshel]

I know. It was beautiful. It was amazing.

[Anastasia Khadrava]

Graduate me to the co host.

[Amitay Eshel]

Your graduate. I wish, I wish you would do every episode with me.

[Anastasia Khadrava]

So don't call me special guests.

[Amitay Eshel]

Special co host. Okay, special agent. Anyway, thank you everyone. This has been a great episode. Anastasia Hojaiva is here with me and if you liked what you heard you want to try the products? There is a special code podcast. 10, you get 10% off your [e-mail]. go crazy with it. It's not limited. You could, you could combine it with whatever, whatever's going on. Whatever's going on.

[Anastasia Khadrava]

Oh my God.

[Amitay Eshel]

On the web, on the, on the website. And yeah, if you have any questions, you can email us, you can, you can ask on Instagram, whatever, and we'll see you here next time. Thank you, Anastasia, for being an amazing co host.

[Anastasia Khadrava]

Okay, next time I promise I will, I will close the episode. I just, I, I, I see, I blanked. But I want to thank you so great today. I want to say thank you for taking us along and I also want to take a moment actually. Sorry, I'm taking them along.

[Amitay Eshel]

What do you mean they're taking us along? We're in their drive right now.

[Anastasia Khadrava]

I know they're driving right now. Most of them are driving right now somewhere. Most of listeners, you need to remember probably cleaning the house, some washing dishes, some work out on a treadmill.

[Amitay Eshel]

Yes.

[Anastasia Khadrava]

So whatever you're doing, thank you.

[Amitay Eshel]

Wait, wait, no, no, no. Treadmill. No, no, no, no.

[Anastasia Khadrava]

Weightlifting.

[Amitay Eshel]

Yeah, weightlifting.

[Anastasia Khadrava]

Lifting weights. But I wanted to say that actually we're updating some files in our Google Drive in our office and I got.

[Amitay Eshel]

I have Google Drive face.

[Anastasia Khadrava]

And I got a file with such sweet emails that we received speaking to our podcast. Thank you for a podcast. Like really, really sweet ones. Right now I don't have them handy and I know we will in the future read some of them. I just wanted to take a moment and thank everyone that sent a sweet note, whichever way possible. You know, be it the email DM on Instagram. Thank you guys. It really means a lot. But if you didn't, but if you didn't and you want to and you know who you are, the best place to do it is actually in the review section with the, you know, wherever you consume this podcast. So if it's Apple podcasts, leave a review. Spotify or YouTube leave a comment. That really helps us and that's something that we see first. So thank you and thank you and thank you.

[Amitay Eshel]

Bye.

[Anastasia Khadrava]

Bye. Bye. It.