← Biohacking Beauty: The Anti-Aging Skincare Podcast
Biohacking Beauty: The Anti-Aging Skincare Podcast
Why Collagen Doesn’t Work Without Vitamin C + Other Supplement Truths
00:52:35
Loading summary
Transcript168 lines
- [00:06]
A
Welcome back to Biohacking Beauty. I'm your host, Amitai Eshel, co founder of Young Goose Skincare. And today I am again joined by my incredible co founder and partner, Anastasia Hojaiva.
- [00:26]
B
Hey everyone. We're excited for this one because we're talking about something that goes way beyond creams and serums. We're diving into supplements that can actually change your skin from inside out.
- [00:39]
A
Exactly. If you've ever looked at a label and wondered whether vitamin C or collagen actually does anything for your skin, we're here to help you sort through all of it. Today's episode is structured in three level levels, kind of similar to what we did last time, right? Like foundation foundational supplements, the mid level power players, and the cutting edge biohacking breakthroughs.
- [01:11]
B
Woohoo. And as always, everything is grounded in science, not hype. We're going to walk through protocols you can start today, the mechanisms behind how these supplements work and will even challenge some of the common myths.
- [01:27]
A
So quick reminder, if you want to complement your internal protocol with our Biohacking Skincare line, head over to young goose.com and use code podcast10 for 10% off. I almost did it without stumbling on my own words and couldn't pull it off anyway.
- [01:47]
B
Yeah, and before we actually get into today's episode, I also want to read a listener's review, which actually today I'm going to read two because I couldn't choose one. And they're both so sweet. So they're short though. One is from Olia and it says this is one of the best new podcasts I've heard. They combine beauty trends people care about and actually use real science to speak about them, which is very sweet, very cool. That's what I hope for all of our listeners to get out of it. And another username which doesn't say much, it's 62kdp, but it's.
- [02:26]
A
What do you mean? 60 Duke dip.
- [02:28]
B
Yeah. However, the review is very sweet, so it says, so informative. Even though the content is sometimes over my head, I always learn something keep it coming. Especially the myth trend busting and there's like four exclamation marks, so we gotta keep it coming.
- [02:47]
A
Okay. Yes, let's keep them coming.
- [02:49]
B
Yes. So thank you guys so much for leaving those reviews. We read all of them and they really help us reach more listeners like you. So thank you.
- [02:57]
A
All right, Anastasia, remember when we first started Yungoos and realized most people are skipping the basics?
- [03:06]
B
Yeah.
- [03:06]
A
They. Well, they were looking for, like, why they were coming to Us, they were looking for cutting edge tools, but I think a lot of them were missing the foundational nutrients for sure.
- [03:19]
B
So. And the truth is your skin can't build or repair anything properly without this, this nutrients you're talking about. So let's start with the basics. Your skin needs the vitamins I'm going to be talking about, and therefore you should consider supplementing with them. So the basics will be vitamin C, vitamin E, Collagen peptides, omega 3s, what else? Vitamin D and hyaluronic acid.
- [03:48]
A
Okay, let's zoom in on vitamin C. It's not just for immunity. Actually, it's not really that great for immunity. New studies show you need to supplement on it quite often if you really want to boost your immunity.
- [04:01]
B
The vitamin C. Yes. And that's what that's known for everyone. Everyone, when they're traveling, they're like loaded up in vitamin C and then they don't take it the other times.
- [04:10]
A
Exactly. But what really, what it's really great for, it's a co factor in collagen production. Without it, collagen molecules can't form properly. So I would equate it to like having like a brick wall where the bricks that like the cement between the bricks, like it's all crumbly. It doesn't have like whatever material to make it not crumbly. Okay. So your skin becomes weaker and more prone to wrinkles if you have deficit in vitamin C. Yeah. Vitamin C deficiency. It's actually 10 times harder for your skin to create collagen without the presence of vitamin C. Yeah.
- [04:48]
B
And we actually talked about it in like a more in a different way. When? Long time ago, like a year ago. We had a deep dive on retinol and retinoids in general. And we talked about that if you already have retinoids in your skincare regimen, you must also have vitamin C serum because, you know, vitamin C is essential for collagen and the retinol kind of like, you know, they're, they're working together. Like one is calling for collagen production and another one is actually employing it. So which is. Vitamin C is the one who helps to create collagen and the retinol will employ it. But if you don't have the vitamin C, then it's only gonna do half of the job and gonna be much less efficient. Interesting research has come up where women in their 40s started taking 1,000 milligrams of liposomal vitamin C daily. And within weeks they noticed their skin not just brighter, it felt Firmer and less flaky. Their moisturizers wasn't doing that alone. So make sure that you take also forms that bound to minerals like sodium ascorbate.
- [05:55]
A
Vitamin E is another antioxidant that definitely complements vitamin C because it protects lipid membranes together with vitamin C. So that's quite important. There is also collagen peptides that I would categorize now as kind of the base layer that what people are using. It's important to know that hydrolyzed forms are the most bioavailable. And you are supporting collagen production by providing amino acids or amino acid building blocks that then your skin may use to rebuild collagen. It's not a direct one to one link, but your replenishing reservoirs your skin calls on when making its own collagen.
- [06:45]
B
Yeah, let's talk about omega 3s. Yeah, yeah. So you probably guys know about omega 3s like EPA and DHA from fish or algae. You know, they're amazing for keeping your skin looking young. They kind of help your cell membranes, you know, to retain themselves. And I personally always like, if I'm like, I noticed that when we recommend to our clients to start supplementing omega 3s, they're, they always support like a plumper looking skin. And that has to do with the, the enhancement of the cell membrane.
- [07:17]
A
They lower inflammation.
- [07:20]
B
Yeah, they dial down inflammation that breaks down collagen and causes wrinkles. And studies show they can even protect against UV damage. So almost like internal sunscreen. Of course, it's not internal sunscreen. Don't go to the sun just with omega 3s that you took before. But you know, but it's helpful going.
- [07:38]
A
Out to the sun with the, with the salmon between your teeth.
- [07:42]
B
Yes. Listen, some, some people would. If we don't do the disclaimers here, so. Plus the Omega 3s help your skin stay hydrated. It even might slow cellular aging by supporting longer telomeres. Getting enough omega 3s through diet or supplements can really give your skin that extra glow and plumpness we talked about. So aim for an omega 3 index about 8% above 8% with diet and supplements.
- [08:13]
A
Before we move on, can you expand on the omega 3 index a little bit? Because I bet a lot of people listening to this are hearing this for the first time.
- [08:23]
B
Ah, absolutely. So let's dive into that. Because the omega 3 index is such a crucial biomarker. It's basically the percentage of EPA and DHA in your red blood cell membranes, giving a snapshot of Your long term Omega 3 status way better than just plasma levels, since this reflects tissue incorporation over months. And that's why we recommend to aim for at least 8% or higher, because the data shows that's where you start seeing major protective benefits.
- [08:56]
A
Yeah. I think Rhonda Patrick says like 8 to 12%.
- [08:59]
B
Yeah.
- [09:01]
A
To aim to Rhonda Patrick levels over six is normally considered good. Hyaluronic acid often gets used topically. We definitely use advanced forms of it. But oral forms have shown in clinical trials to improve skin hydration and elasticity within two to eight weeks. Actually, much better than topical. It works by drawing water into the extracellular matrix, which is essential for kind of like plumping your skin from the inside. But in general, it is essential for the ways our cells hold on to moisture.
- [09:39]
B
Yeah, we're all about that plumpness. Plump you up. Hyaluronic acid. Plump you up. Just get all plumped up.
- [09:46]
A
Plump, plump, plump, Plump you up. Anyway, but I really think it's important to understand that this is a. It could be gut irritating a little bit. So. Yeah. So people should know. And we get.
- [09:59]
B
You know, I didn't know that.
- [10:01]
A
Yeah. Because I don't let you take too much. But. Yeah.
- [10:04]
B
Thank you. Thank you for looking out for me.
- [10:06]
A
You're welcome anytime. Anyway. But.
- [10:09]
B
But all of it's so hard, so difficult.
- [10:13]
A
But all I'm saying is this. It is a much more effective molecule when taking or when taken orally than when applied on the skin. When you apply hyaluronic acid on the skin, you're not really improving the extracellular hydration levels by kind of infusing hyaluronic acid into that area. You're improving the skin barrier that doesn't allow moisture to leave the skin as easily. So you're not actually, like, giving your skin more moisture artificially. Right. Like, hyaluronic acid, when you take it orally, does wonders because it allows your cells to hold on to more moisture and from the inside out. So bear that in mind.
- [10:51]
B
I remember you had a really, like, a deep dive On it with Dr. Amy Killen when she was. Yeah, when you guys recorded and, you know, you take it in the hot box. Shout out to the hubbox.
- [11:03]
A
Yes.
- [11:03]
B
You know what I realized? I run after you with the sunscreen, and you run after me with the supplements.
- [11:09]
A
Yes, that is true.
- [11:11]
B
Yeah. Without them, I would be taking, like, three supplements that I'm convinced that supplementing on air. No, I. I by myself, without you, I will take NAT plus precursors. I'm taking my spermidine and I take phosphatidylcholine well, also magnesium.
- [11:28]
A
Shout out to Lev, our baby, the baby that likes phosphatidylcholine the most out of any babies ever.
- [11:34]
B
A shout out to Jess Kane, the founder of Body Bio. She told me that she has. She's a mother of three kids and she told me she started giving her kids like almost from birth, post fetal colon and ours was already one year when started giving it to him. It's bitter to me. It's not bitter to him. And he actually says yum yum.
- [11:55]
A
Called it yum yum. Spoiler alert. Dr. Perricone is actually going to release a book claiming that choline is the most important molecule for longevity. I disagree, but I think it's important to understand like how important this molecule is for like skin health.
- [12:10]
B
So, so the mentioned supplements, these are the ones that I'm disciplined and diligent and convinced enough to take by myself. Everything else that I take, it's just, I meant I feeds me some supplements sometimes I don't even know what they are.
- [12:24]
A
Yeah, the blue one, the red one. Anyway, let's vitamin D. Yeah, let's vitamin D, the vitamin of these.
- [12:30]
B
Okay. So vitamin D is critical for skin barrier integrity, especially in winter months or if you protect your sk from the sun as you should, but therefore, you know, to support your skin barrier integrity, you could be supplementing in vitamin D. But I will say, in my humble opinion, protecting your skin from the sun gives you a lot more anti aging effects than if you were exposing it to the sun. Getting that vitamin D for, you know, whatever effects on the barrier integrity, but then just basically getting all the pigmentation and wrinkles.
- [13:04]
A
Yeah, there's a balance, you know, you can expose other parts of the body. You can take supplementation as well.
- [13:10]
B
Yeah.
- [13:11]
A
So a simple starting plan would be I would say about a thousand milligrams of vitamin C in liposomal sodium ascorbin. Mineral. Yeah, spoiler alert. But mineral bound form such as sodium ascorbate, if you are undergoing some kind of repair, if you did like any type of procedure, if you are trying to boost your collagen production levels because you are again recovering or something like that, you could even take 2 to 4 grams a day, split into two instances that you're taking it. Vitamin E, I would say at least 400 IUs daily. Collagen peptides, depends on the form that you're taking, but I would say about 5 to 10 grams. In your morning coffee or smoothie.
- [14:06]
B
Just make sure it's cold coffee. Please don't put it in your hot coffee, it's gonna degrade.
- [14:11]
A
Yeah. Smoothie then. Hyaluronic acid, 200 to 500 milligrams daily. I would start low and then see how my stomach reacts. Omega 3s, 1000mg of EPA, DHA combined once or twice daily. Vitamin D, 1000-2000ius, especially if you're deficient. If you. If it's the winter, if you're not getting any, if you have darker skin tone, you can even go to 5,000 to 10,000 IUs. But start, start there. Phosphatidylcholine. I would say, like, just buy the Body Bio PC and take like a teaspoon.
- [14:50]
B
It sounds like we're sponsored by Body Bio today.
- [14:52]
A
We're not the opposite of sponsors.
- [14:54]
B
We're not.
- [14:55]
A
We're buying their stuff.
- [14:56]
B
But actually, I will invite Jess on a podcast. She's already invited and we will be recording in the future because I just really love that particular supplement and others and just want you guys to learn from her. She's a wealth of knowledge.
- [15:11]
A
Correct.
- [15:12]
B
So everyone loves topical vitamin C. But here's the thing. Topicals only work where you apply them. However, if we're talking about oral supplementation, you get systemic support, including dermal fibroblasts that actually build collagen from within. You know, you can support them this way. Same thing with hyaluronic acid. As Amitay mentioned, when you apply it topically, it only hydrates the surface layer, but oral forms replenish internal hydration much more deeply.
- [15:41]
A
Yeah, I would start here. You know, these are kind of the basics, the basic building blocks, if you will, the basic foundation that your skin that your skin needs before you reach for anything further foreign. Let's take a quick break from this episode to tell you about our new Youth Firming body cream. If you're tired of body lotions that just sit on the surface, it's time to upgrade to something that actually works from the inside out on an epigenetic level. Yungoos Youth Body Cream isn't just your typical moisturizer. We've powered it with Nad Apex, Stelvio spermidine longevity mushrooms, and ergothione and lemongrass extract with lipopeptides. This is a formula that literally reprograms how your skin ages. It restores cellular energy, boosts collagen production, and clears out cellular waste like senescent cells, targeting those problem areas like your arms, legs, neck, and decollete, where aging shows up first. Think of it as a Biological reset for your entire body skin. Because when your skin gets the science it deserves, the results speak for themselves. Ready for your full body Upgrade? Visit young goose.com today and discover what happens when longevity science meets skincare. You can grab the link in the show notes below. But let's move on to the next level. You graduated, you got here, you graduated.
- [17:36]
B
Okay, well next level is really where we start seeing the real transformation. These aren't extreme supplements, but they're strategic. So we're talking about CoQ10, curcumin, EGCG, resveratrol.
- [17:52]
A
Yeah.
- [17:53]
B
So CoQ10, astaxanthin.
- [17:55]
A
Astaxanthin, yeah. So CoQ10 is huge not only for skin, for mitochondrial function in general, but it is huge for skin. It's part of the mitochondrial electron transport chain. So if it. So so basically it fuels the production of energy in, in fibroblast in the, in the cells that create collagen, elastin, hyaluronic acid. This type of energy is called, is called ATP or adenosine triphosphates. So obviously like more energy equals better collagen or better skin repair.
- [18:32]
B
Yeah, well, you know, I personally really get excited when for any chance to talk about Coq 10 because it, I think it really tackles things like chronic fatigue and those, you know, the. Everyone doesn't love their dark under eyes. And there is promising data that if you supplement on CoQ10 that could really help to alleviate that by the mechanism of like boosting mitochondrial function and reducing oxidative stress. And we've seen in practice how the ubiquinol from can lead to visible improvements in skin tone and reduced puffiness in as little as three weeks, mirroring what studies show for fatigue relief and skin health.
- [19:15]
A
Curcumin, which is the next one you mentioned or which is basically the active ingredient in turmeric, is really interesting because it works by inhibiting what we call NF Kappa beta or the master switch of inflammation. So it reduces inflammatory signals that are the kind of the main drivers of collagen breakdown. So it's also a mild sirtuin activator, meaning it contributes to cellular resilience or the contributes to youthful epigenetic function if you want kind of cells know what they need to do, which obviously is important.
- [19:58]
B
Yeah, I love that curcumin works for you. I can't take it. It makes me like smell really bad. Gives me bo, unfortunately.
- [20:07]
A
Maybe that's what your cells need to.
- [20:09]
B
Do to do to produce BO or to take curcumin both and I mean, I'm. I'm lucky that you don't mind, but I mind. Yeah. And I tried different kinds. I mean, there were a couple of supplements that we were taking, which I'm.
- [20:25]
A
Not going to mention that you are taking curcumin.
- [20:28]
B
So that's what I was going to say, that we. There were a couple that have curcumin, and I couldn't take it because it was just like, I couldn't. And I even talked to the formulator of them. I was like, listen, I would love to take it. And was also actually really good for sleep, if you remember, if you know what I'm talking about, which one I'm referring to. But I can't. It just makes me smell like I can't shower three times a day. It's not healthy. And they're like, oh, well, you smell great. I'm like, no, I don't. But this other one. Yeah, that I'm taking now. A part of. It's. It's better.
- [20:59]
A
Yes.
- [20:59]
B
Well, moving on to the EGCG from Green team. So the science baking, it is pretty robust. It's incredibly powerful for preventing pigmentation issues by shielding the skin from UV damage and dialing down oxidative stress right at the source before it spirals into discoloration and photo aging.
- [21:20]
A
Yes. And the challenge that we've had with it when formulating is it's just so, so not stable.
- [21:30]
B
And we also found better alternatives.
- [21:31]
A
Yes, we found better alternatives. But I was saying as a. As a. Just as an ingredient, it's an excellent ingredient, especially as a supplement. Another excellent ingredient, which, you know, like.
- [21:43]
B
Reminder, guys, this episode is really about what we recommend to take orally.
- [21:47]
A
Yes. 100%.
- [21:48]
B
Just. Just FYI, if you forgot.
- [21:50]
A
Yes. And another one that is great as an oral, but is pretty problematic topically is astaxanthin.
- [22:00]
B
That's such a buzzword. Is it astaxanthin? Yeah. And a couple of people just last week reached out to you. Like, you. Oh, my God, I love that I'm not your secretary, but I end up being one because I finally, you know, I help you remember to take, to get back to people. But yeah, people have asked you two different people ask you just last week, what are your thoughts on astaxanthine? So go on.
- [22:21]
A
So here's the really cool thing about astaxanthin, which is a. Basically, it's an antioxidant that has high affinity to skin. So your body actually expresses it really well in the skin, even if you take it Orally and it's much more effective orally, it has much higher bioavailability. Orally it absorbs really well. You don't need to manipulate it as much because it's smells fishy. So if you have it, if you apply it topically, it's quite challenging like to make it not smell like fish.
- [22:53]
B
Yeah. User experience. Like you don't want to walk around smelling like a fish.
- [22:56]
A
Yeah. And topically there are just better antioxidants. The real magic of Estadanthin is that you take it orally. And as opposed to other things that we talk about often like nad spermidine, I don't know, vitamin C, your body actually just immediately knows that it wants to express it in the skin. So that's a positive thing. To give you a reference, it's 500 times more potent than vitamin E at neutralizing free radicals, specifically in the skin and improving things like elasticity, hydration and even resilience against sun exposure.
- [23:38]
B
Yeah, no, it's pretty cool. It's pretty cool. So. And I think that's why it's so such a buzz ingredient right now for oral supplementation. And like you said, it's been trying. Some companies try to incorporate it in topical and for the reasons you mentioned, we don't think that's such a great idea. So. Okay, let me give you guys a simple four step protocol. So you can start with CoQ10 at 100 to 200 milligrams a day in the ubiquinol form for better absorption and mitochondrial support. Then if you can take curcumin at 500 milligram a day a pair it with black pepper, you can just crack it up and you know, add to your.
- [24:21]
A
Yeah, but supplements, it's in supplements.
- [24:24]
B
Yeah. To improve bioavailability or safe. That's already done for you.
- [24:29]
A
Yeah. The patented form of that is called bioperine I believe. And that's normally how you're going to see, you're going to see bioperine and curcumin.
- [24:36]
B
Yeah. So that's already with that pepper. So those fight inflammation and then EGCG at 200 to 300 milligrams a day, which is the equivalent from two cups of matcha and green tea. For that I personally switched to drinking matcha at home. Like that's just, you know, sharing with you guys. It took me probably like, I would say almost three years to like not drink coffee at home and drink matcha. I was in love from first sight. I did not like the taste of it. For the longest time. And I was envious of all the girlies that just love their matcha lattes and, and that's their go tos and like I just want coffee, but it's actually I don't metabolize it very well. Like I metabolize it very slowly so it makes me very jittery. But then for skin health in particular, Matcha is amazing. And the reason it's amazing, it's because it's rich in this egcg. So you know, just, just, just a fun fact that if you're like, if you like both, you like coffee and you like matcha and you're like, what's better for my skin? It's Matcha. Matcha is better for your skin than coffee.
- [25:49]
A
It's Matcha. Matcha. Better.
- [25:51]
B
Yes, yes. So just a side note and, and it's fun that it also has like photoprotective properties. You know, you drink your matcha for your like very smooth caffeine boost. I love that. What's this? The name of this ingredient. It's skipping my mind now that it has. That's why it doesn't give me the crush. Matcha has caffeine and. Oh yeah, that's what it is. So yeah.
- [26:19]
A
Anyway, if you're the way like, let's take a side note, just not, it's not about skin at all. That's like, if you, if people see nootropics, especially like classic nootropics, the way that they will like the classic, most like basic nootropic idea is to combine uppers and downers basically is to combine things that create energy and things that calm the nervous system at the same time. And I mean, matcha is like the nature's version of that because it has caffeine and it has L theanine. So.
- [26:59]
B
Yeah, well, you have to also think of origin of your matcha. Speaking of like quality control and stuff. But yeah, I get mine from Kyoto, so try to look for a good source of it.
- [27:13]
A
Yes.
- [27:14]
B
Okay.
- [27:15]
A
You want to plug the one that we're.
- [27:18]
B
So I'm using cousins. It's C U Z E N. It's a Japanese manufacturer. It's a, it's. It's basically similar like an espresso machine, but it's a matcha machine that makes you fresh matcha at home and it like cracks leaves of matcha. Fresh. Well, not fresh. It's. They're dried out matcha leaves and it's.
- [27:40]
A
Really cool and it frosts them.
- [27:42]
B
It frosts them? Yeah. No, it's definitely very cool. I personally drink my matcha, like unsweetened. Sometimes I will add raw milk if we have it, but most of the time it's like a matcha Americano. Like I just matcha and like I either will have it over ice now that it's hot, I'll have it with just a little bit more of water. But yeah, one of the times that I really, what really helped me to make a switch was when I was pregnant and I didn't want to take coffee anymore. That was such a clear source, like clean and clear source of energy and I kind of stuck with it. And it's just like again, just sharing with you guys for tips for your skin health and tricks. It's much better. And for me personally, it's also better energy wise. It helps me not to have a crash during the day.
- [28:28]
A
Okay, what about astaxanthin?
- [28:30]
B
Astaxanthin. So actually much slower concentration, 6-12mg a day, taken with a fatty meal to enhance uptake and deliver those antioxidant benefits for skin resilience from within. Remember, it's all supplements. Oral supplements.
- [28:46]
A
Yes. I'll give you a little bit of a contrarian take. So not contrarian, but like just something people should be aware of. Statin drugs deplete CoQ10.
- [28:56]
B
Yeah.
- [28:57]
A
So if you're taking one or if you're taking a statin, you are accelerating aging unless you replenish Coq 10 also. I can't believe that I still need to say that. I don't know, but I'll say it. You can't. I. There's a meme like that, but I forgot how it it goes. So forget trying to get adequate amount of resveratrol from drinking wine. Okay. It would take 1000 glasses of wines or bottles of wine, one or the other. I forget the number to match in wine pool. Yes. Yeah. No, no, you're. Listen, you don't have the money to do that. Okay. Listen, Unless you buy. What's it called? The Barefoot Wine.
- [29:44]
B
Oh, yeah.
- [29:46]
A
Is it sold in like cooking wine?
- [29:48]
B
Unless you're drinking cooking wine.
- [29:49]
A
Anyway, listen, you're not, you know, doing yourself favor. Yeah. There's a reason you don't see like you don't see alcoholics with beautiful skin.
- [29:59]
B
Well, on that note, actually, yes, I think it's worth mentioning and I know that's not what this podcast is about right this moment. It's about supplements, this episode. But as a podcast as a whole, we are all about skin health and Obviously, you know, you can have some wine in moderation. Right. Whatever that is for you. But just know that alcohol consumption really shows up in your skin. It really does dehydrate your skin. And the people that just decided to, you know, detox from alcohol or, you know, stop drinking alcohol, without a doubt, their skin gotten better. Again, I'm not here to. To preach or say, like, don't drink alcohol ever, but if your goal is to be the Tom Brady of skin health, he probably wouldn't drink, you know.
- [30:45]
A
Yeah, no, if he drinks already, I'm sure it's like martinis or something like fancy Tom Brady.
- [30:50]
B
Yeah.
- [30:51]
A
Anyway, so another take I'll say is like astaxanthin. It is a game changer as a complement, as an oral compliment to topical spf.
- [31:03]
B
Yeah. The research shows it works from the inside out to mitigate sun damage by boosting skin's defenses against UV induced deterioration, improving elasticity and hydration.
- [31:14]
A
Yeah. So I would say it's probably like an SPF3. You know, it adds like a, you know, let's say you apply BioShield SPF 40. So now it's 43. Okay.
- [31:26]
B
Yeah.
- [31:29]
A
Let's take a quick break from this episode to discuss the skincare that makes big promises but delivers small results. We know how tiring it can be. Yungoos isn't playing that game. This is longevity science for your skin, where breakthrough ingredients meet real results. For example, our bio barrier formula features LPC6, an antioxidant that's 20 times more more powerful than vitamin C. We're talking triple action defense against every type of free radical that ages your skin. And our revolutionary spermidine serums, the first skincare products to harness this cellular powerhouse that literally triggers your skin's renewal process. Every Yungoos product targets aging at the molecular epigenetic level. NAD precursors that restore cellular energy, peptides that rebuild collagen, bioidentical compounds that reinforce your skin's natural defenses. This isn't surface level skincare. This is your skin's biological reset. Whether you're dealing with dryness, signs of aging, or just want skin that actually looks as good as you feel, young goose has cracked the code on what your skin really needs. If you're ready to experience what happens when science meets skincare, check out the Yungoos link in the show notes or go to yungoos.com because your skin deserves the future, not just another cream. So now we're going to layer. Okay. Now we had the foundational nutrients targeted, you know, Kind of boosters that we talked about that, that do more of like a visible change. Now I want to talk about like a more advanced biohacking things.
- [33:32]
B
Let's do it. Let's dive into longevity. The crowds favorites. Okay, so these supplements that target aging right at the cellular root, not just protecting the skin, but essentially reprogramming it for better resilience and vitality. And the emerging data, and the emerging data on how they influence hallmarks like DNA repair and inflammation. This is really fascinating. So here's what we'll cover. Let's talk about NMN as an NAD precursor. Analytics like visiting and cursing ergothioneine and NRF2 activators such as sulforaphane.
- [34:15]
A
Okay, so let's first, you know, let's talk about nmn. So we've recently had a podcast, you know, diving deep into kind of nad. So I would really recommend like going there if you want a deep dive on that specifically. But here we're choosing our choice of, of the supplement form. Right. Kind of going there. So NMN is definitely like the real deal as far as boosting NAD levels. In turn, NAD fuels DNA repair, DNA repair enzymes for that matter. So parps and sirtuins come to mind and it supports cellular metabolism so how much energy our cells can make. Similar to what we said before. So we've seen people on NMN report anything from brighter skin, brighter, better elasticity and even improved barrier function. I would say that's mainly when you combine it with topical NMN like our NAD apex complex that we have in our products. But it is crucial to have high circulating NAD levels in general, both for overall health and for skin health.
- [35:25]
B
Yes. Then another supplement that's often overlooked, it would be ergothinine. The science is very compelling. It's uniquely transported into cells via the OCTN1 transporter, honing in on high oxidative stress zones like mitochondria, acting like precision guided antioxidant that protects against UV damage, DNA breaks and even mitochondrial dysfunction. Potentially outshining glutathione, which is kind of everyone's go to in some context for long term cellular protection.
- [36:03]
A
Yeah, it's definitely, in my opinion, it's probably the best way to upregulate glutathione in the body. Better than nac, better than definitely better than glutathione itself. Another thing that you mentioned kind of in the beginning that I love are senolytics. So senolytic compounds are pretty incredible. There are ones that you can take daily, like spermidine that does more than tackling senescent cells, but that's one of its activities. And then there are ones that you take, you don't take every day. You take them on and off, like fisetin or quercetin, that they help to maybe, like, do a much more precise scalp clearance of senescent cells or zombie cells. So in short, again, we've done many podcasts where we explain that. But in short, zombie cells don't die. They kind of stay in a limbo between a cell that doesn't contribute at all and a cell that actually kind of drives aging by secreting inflammatory molecules that damage surrounding skin tissue. It's part of aging, accumulating those cells. So we definitely want to kind of limit the amount that we accumulate day to day through things like spermidine or by the way, we mentioned NAD before. So we need high NAD levels or else we're going to accumulate those cells. But on the flip side of that, we want to do courses. Maybe, you know, one of the protocol is like two days out of the month you'll have like kind of an antisenescent cell course. So quercetin, fisetin, dasatinib is another one. A brand that does it very well is qualia. They have qualia senolytic. So that would be kind of my recommendation.
- [38:03]
B
We're actually doing a collab with them soon where with the purchase of our products, you will be getting, like, I forget what it is, either discount code on their products or a store credit. But stay tuned. It will come as a surprise and delay, delight into with surprise. Delay, delight or delay.
- [38:22]
A
No, delight.
- [38:23]
B
Yeah, Delight.
- [38:23]
A
I was joking.
- [38:24]
B
Okay.
- [38:25]
A
Okay, what's next?
- [38:27]
B
Either of two activators like. Oh, my God. Sulforaphane. Sulforaphane. Guys, this is a tongue twister for me.
- [38:35]
A
Yeah.
- [38:35]
B
So the research is, like I was saying before, is very robust. They ramp up your body's own antioxidant enzymes, essentially upgrading your detox pathways and bolstering skin resilience against aging. Stressors. With studies showing real improvements in collagen maintenance and protection from environmental damage through key AP1NRF2 activation.
- [39:01]
A
Yeah. So here is a protocol. I would say NMN about a gram daily senolytics, 500 gram milligrams ficitine plus one gram quercetin, three days, let's say per month and two to six grams of full spectrum spermidine, such as spermidine life would be ideal. We don't want to take an isolate because it's not corresponding with how Our body kind of corresponds with spermidine. So Spermidine Life or Oxford Health, which they have, Oxford Health, they have Primadine. These are two good companies. Two to six grams of that Ergothioneine, one to five milligram milligrams daily. Sulforaphane, 10 to 20 milligrams daily. I recommend it from broccoli sprout extract or capsules. There is a company called Brock Elite. That's what we take.
- [40:04]
B
Yeah, no, I think that's great. I, I just want to be again here with PSA that this is not a medical advice. Like these are our recommendations and we are very in tune with your guys questions and requests. We get a lot of, a lot of DMS asking like, oh, please recommend a supplement regimen. And that's what we recommend. But if you already work with longevity doctor, if you, you know, just like, I guess just pay attention to your labs, see that these are the supplements that, you know, good for you, work for you. But yeah, these are our recommendations.
- [40:41]
A
I would say this could be good questions to ask a practitioner you're already working with.
- [40:46]
B
Yeah, no, yeah, and that's also true. Like sometimes, as you guys know, sometimes the biohackers might educate their doctors on some newer compounds. And we definitely strive to bring you all the latest data and the latest information and sometimes it could be ahead of someone's education, you know.
- [41:09]
A
So, yeah, one thing your provider can do is basically order for you our metabolomic test, which is not out yet, but upon request, physicians already can order it for their patients. About two weeks after you send the dry blood spot to the lab, you'll be able to get a full detailed breakdown of your specific skin needs. So what molecules you're deficient in. And then obviously a combination of topicals, skincare or oral supplements could be used in order to offset those deficiencies. So that's obviously a much more detailed version, but that's kind of a general strokes of what you need. I'd give two honorable mentions. Which one is creatine? The reason I'm saying it is because it's an incredible supplement for increasing cell cellular energy. There's just not very robust data around how it does it specifically in the skin. It's like more about muscle tissue, things like that. But I'm sure the data is going to arise.
- [42:21]
B
Yeah, I'm actually going to record like a short solo episode.
- [42:25]
A
Yeah, just. Yeah, we're definitely working on research around it. And another one is sod, Superoxide dismutase. Same thing. Incredible molecule Very difficult to formulate with. So there is one company that has a oral version called Glycidin G L Y S O D I N available on Amazon. Glycitin. And stay tuned for a topical version.
- [42:53]
B
Anyway, so, okay, I do want to address one other kind of question that came in before, which is why would one only focus on collagen, you know, when you could eliminate the senescent cells driving visible aging in the first place, and then hopefully, like, you, you know, you won't have that collagen breakdown? I guess that was the question. So analytics like fistine and quercetin are absolute game changers with solid evidence from animal and human studies showing they clear out those zombie cells, reduce inflammation, and extend healthspan. Did you want to say something?
- [43:35]
A
I want to say that I see this approach a lot. It's like, all I need to do is to take care of my senescent cells. But it's almost saying, hey, I have. I need to go get a stint in my heart. I have, like, you know, I have clogged arteries. All I need to do is to fix the clogged artery. The clogged artery is a eventuality of a lifestyle that got you there. You know, inflammation would drive deposition of plaque in your arteries, for that matter. Okay. Or fat in your arteries. So you are not treating the root cause. You're treating the eventuality of, in this case, when we're talking about senescent cells of aging. So senescent cells are definitely a hallmark of aging, but they are not the eventuality. They are the effect. They're not the cause. They then are a cause of things like wrinkle or accelerated aging. But clearing them does not address the reason they accumulate to begin with. Okay, so what we are saying, when we're saying spermidine or NAD or ergothioneine or, I don't know, creatine or things that we didn't mention because they are. I would say, again, there is more study that needs to be done, like alpha ketoglutarate or, you know, I don't know, I can name. I can throw a bunch of random letters around. I'm probably going to hit something. What you want to do is climb up the eventuality. Kind of what we call the cascade of metabolic events. Right? Like a climb upstream and start from correcting deficiencies, correcting the reasons we are aging in the first place. And then it will do two things. You'll have less senescent cells, and it would be much easier to deal with senescent cells. Because senescence is a burden, the bigger the burden, it's harder to lift. Okay, so it's exactly like we said in the podcast about pigmentation. Exactly like we said about the. In the podcast about it. And I did exactly like the. That we set up a year ago with a podcast about retinol when we talked about, like, you know, vitamin. You need also vitamin C. You need the basic things to work properly. You need your high NAD levels, you need autophagy, you need excellent mitochondrial function. And then dealing with senescent cells going to be much easier. Senescent cells is not the end all, be all. It's not the panacea. It's actually a fire alarm that you need to address rather than finding the arsonist. I like my analogy there. Okay.
- [46:24]
B
I think this is great. I think really this is kind of perfect way to wrap this up. I think what you outlined is really where the supplements kind of turn into skin Longevity protocol regimen tool.
- [46:38]
A
Okay.
- [46:38]
B
Yeah.
- [46:39]
A
I would want to ask you. So we kind of have time. I think I'll give another honorable mention, which is kind of weird because it is a supplement, but it's not really a supplement. It's five amino, one mq. The reason I'm mentioning it's a peptide, it's an oral peptide, and it's an oral peptide that boosts NAD levels. I'll say two reasons why it's in honorable mention and not like something a part of a protocol. First and foremost, there is more research that needs to be done. But what it does, it boosts NAD levels by mimicking exercise. So it tricks ourselves to think they're exercising and we take it orally four weeks on, two weeks off. And again, maintaining high NAD levels is essential for skin health. And the cool thing about it is that this does actually reach our skin because it's a peptide that kind of propagates throughout our system as number one. Another honorable mention. And then I'll give. I'll put it on you to give us some honorable mentions, if you would. Another honorable mention that I would say is kpv, which is another peptide that you can take orally and it lowers inflammation, especially in your gut. And one of the things that are important for skin health is demand of other tissue for collagen. So if our gut is leaky and is basically getting damaged, or if our joints are getting basically damaged quickly, these things demand building blocks of collagen to kind of repair that, and then our skin's gonna have less. So here are two that I'm gonna throw out there for people to maybe be interested in. What about you give me like a random or like a kind of out, out of the box type supplement, if you would. Yeah.
- [48:25]
B
Something that we didn't talk about. Yeah, let me think. I don't know. Again, I'm such a minimalist when it comes to supplements. Everything I take we talked about, like, we didn't talk about magnesium, but that's, you know, that's. That's important. That helps you. You know, it's. It's like a co factor in a lot of cellular processes and it definitely helps you sleep better, which is you. To sleep is the key to beauty.
- [48:53]
A
That's why you actually also mentioned L. Theanine. So technically that could also be used for sleep.
- [48:58]
B
Yeah, yeah, that is true. We are at time, though. We are going over an hour.
- [49:03]
A
You did remind. Really? Whoa. So you did remind.
- [49:06]
B
It applies when you're having fun.
- [49:08]
A
Yes, that's true. Okay, never mind. I'm not gonna. Reminded me something, but I'll leave it for. Maybe we'll do an episode about it or something.
- [49:15]
B
Anyway, I think the amount of information we threw at our listeners is pretty. Like, it's a lot. If somebody was driving, they couldn't take notes. They have to go back, write all.
- [49:26]
A
Those protocols down or we've just jeopardized a lot of lives on the road. Anyway, now that I know we're timed here. Thanks so much, everyone for tuning in to Biohacking Beauty. We covered, as Anastasia said, a lot, from foundational nutrients to some of the most advanced skin supporting compounds out there. Yeah, Nastya, what do you have to.
- [49:52]
B
Say if you found this helpful? Be sure to subscribe and leave us a review on Apple Podcast or your favorite platform. I will read it for you in the beginning of the next podcast. So, you know, hopefully that's a motivation for you guys.
- [50:07]
A
Yeah. So try to be creative.
- [50:08]
B
And truthfully, it helps us grow. The fact that our podcast grows and it's actually number two now in beauty Worldwide, which is so, so cool.
- [50:21]
A
You guys got to help us to get to number one.
- [50:23]
B
You guys really got to help us get to number one. We're almost there. We're almost there. We're like hovering between 1 and 2. But that also helps us bring you the best guests, the best information. So. Yeah, and you fuel that by leaving a review, which very easy and brief. And you don't actually. I said be creative. You don't have to be creative. Even a one word review. Really helpful. Yeah, your zip code, your zip code and then we'll tell you where to find professional provider. If you want to get professional treatments by young goose trained estheticians with products that are not available over the counter. Oh, that metabolomics test for example. If you want to get your hands on that, that is only through providers because we want you to get the best care and education, you know, while you analyze your data.
- [51:14]
A
But you know, it's kind of cool if people. I don't suggest that people really leave their zip code, but it would be.
- [51:19]
B
Cool to know where everyone lives.
- [51:21]
A
No, no, that's too pretty, Anastasia. Anyway. I'm kidding. But what I would say is that it would be cool to because it kind of allows us to also highlight providers. Right?
- [51:33]
B
Yeah. And a lot of providers are listening to our podcast. So if you are a provider and you want to be to get a shout out to your clinic, you need to ask for a zip code of that area and then you'll get a shout out.
- [51:48]
A
Yeah, that's really cool. Anyway, thanks everyone for listening. Thank you Anastasia for gracing us with your beautiful presence.
- [51:56]
B
Thank you guys. We love you. Thank you for your support.
- [51:58]
A
I definitely give you a five star review.
- [52:01]
B
Thank you. You're the one who left the reviews.
- [52:04]
A
I guess I'm PKG62. What was that?
- [52:08]
B
Puppy Kittens.
- [52:10]
A
Okay. Okay. We love you guys. Bye.
- [52:13]
B
Bye.