Dr. Fred Appelbaum, Executive Vice President of Fred Hutch Cancer Center, joins Green Bay Oncology physicians Dr. Brian Burnette, Dr. Kamal Abbi, and Dr. Evan Wenig, along with Dr. Brian Merkel, Professor and Chair of Human Biology at the University of Wisconsin–Green Bay, to reflect on one of the earliest eras of bone marrow transplantation through the eyes of both patient and physician. Dr. Merkel recounts his leukemia diagnosis at age 18, the reality of informed consent, and the life-or-death decisions that shaped not only his survival, but his future as a scientist and educator. Together, the group explores how transplantation has evolved—from isolation wards and experimental protocols to outpatient care, clearer communication, and a deeper understanding of the human experience of treatment.

“I was prepared to die. I really was. But I was determined to live and to do what was necessary for my part to make that happen.”
— Dr. Brian Merkel

On this episode of Cancer Covered, you’ll learn:

What “informed consent” really means: Why understanding risk intellectually is different from living through it—and why family conferences can be one of the hardest parts of the transplant process.
How communication reduces fear: The physicians discuss how explaining why treatments are given—using stories, analogies, and repetition—can significantly lower patient anxiety.
The role of trust and self-advocacy: From choosing a transplant center to speaking up when something doesn’t feel right, patient confidence and agency matter.
How transplantation shaped modern cancer care: Early transplant research laid the groundwork for today’s cellular therapies, including CAR-T, and continues to influence the future of oncology.

From Patient to Professor: Dr. Brian Merkel and the Transplant Ripple Effect