Alzheimer's isn't just a diagnosis that shows up in old age. It's a slow metabolic unraveling that can start decades before the first symptom.

In this episode, Jeff sits down with Dr. David Perlmutter, a board-certified neurologist and author of the new book Brain Defenders (out August 18), to unpack what's really driving Alzheimer's and other neurodegenerative diseases. They get into the brain's own immune system, the microglial cells that either protect or destroy your neurons, and why the beta-amyloid hypothesis may have sent decades of research down the wrong path.

Why microglia, not amyloid plaques, may be the true driver of brain degeneration
The link between insulin resistance, blood sugar, and neuroinflammation
How the gut microbiome and oral health shape the brain's immune response
Practical diet, sleep, and supplement strategies to protect your brain starting now

This episode is for anyone who wants to understand Alzheimer's prevention before symptoms start, and for the millions currently caring for a parent or partner facing cognitive decline.

Preorder Dr. David Perlmutter’s new book “Brain Defenders” at braindefenders.com.

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