Rabbi Ami rules that one is liable for placing a leavening agent onto a meal offering dough and leaving it to leaven on its own, just as one is liable on Shabbat for an act of cooking in the same manner. The Gemara questions this, noting Rabbi Yochanan's ruling that on Shabbat, one who places meat on coals is generally only liable if they actively turn the meat. Rava explains that Rabbi Ami's comparison means one is liable for the result even without active intervention, provided the leavening reaches a certain minimum level.

The Gemara delves into Rabbi Yochanan's statement regarding turning the meat and establishes the case as one where the meat would not cook on both sides to the minimum level of ben Drosai (1/3 cooked) if not turned. Rava adds that if a portion the size of a fig-bulk were cooked fully on one side, in one place, one would be liable. A Mishna regarding building on Shabbat is brought as a difficulty for Rava's statement, but the challenge is ultimately rejected. Some have a version where Rava said that even if not in one place, and the Mishna is brought to support, but the support is rejected.

A braita derives from Vayikra 2:11 that the leavening prohibition applies to the entire mincha, not just the kometz burned on the altar. However, it also derives that this applies only to a valid offering, not a disqualified one. This leads to two unresolved inquiries. Rav Papa asks: if one leavened a dough, took it outside the Temple courtyard, and then leavened it further, is there liability for the second stage? Or, is removing it not considered a disqualification since it was already leavened and invalid? Rav Meri asks if one is liable for leavening an offering already on top of the altar, or if the act of "bringing" is considered complete at that point.

The Gemara discusses which additional offerings are included in the prohibition. According to a corrected version, Rabbi Yosi haGelili includes the showbread, while Rabbi Akiva includes the mincha libation accompanying sacrifices. This dispute hinges on whether dry-measure vessels possess the inherent sanctity to disqualify an offering if it leavens within them. This is linked to a debate between Rabbi Yoshiya and Rabbi Yonatan regarding the sanctification of liquid versus dry-measure vessels in the Temple.

The Torah prohibits offering leaven or honey as a fire-offering, and Vayikra 2:11 further teaches that leftovers of various offerings cannot be offered on the altar if a portion has already been burned. Rabbi Yochanan and Rabbi Elazar disagree on whether one is liable for offering these prohibited substances on the ramp (kevesh) of the altar.