Dr. Roger Seheult Dr. Roger Seheult is the co-creator of MedCram Videos. In the early days of the COVID-19 pandemic, MedCram emerged as a beacon of insight, providing continuing coverage and perspectives in an environment almost defined by information scarcity. What particularly excited me about the unique opportunity of this interview is that apart from Dr. Seheult being a unique voice of public scholarship during the early days of the pandemic, he's also a quadruple board-certified pulmonologist with deep experience working on the frontline of the COVID-19 pandemic.

In this episode, we discuss:

(00:00) Introduction
(06:20) How MedCram Videos got started
(09:37) Using evidence to make COVID-19 treatment decisions
(12:46) The differences in treating early vs late-stage COVID-19
(14:40) How doctors would've treated COVID-19 one-hundred years ago
(18:13) Increasing ventilation reduces SARS-CoV-2 transmission
(20:28) Masks are virtually universally beneficial regardless of type
(21:32) Vitamin D and COVID-19
(22:22) Steroid chemical structure of vitamin D
(23:24) The vitamin D RDA is likely too low
(24:23) Vitamin D is more like a hormone than vitamin
(26:21) The overlap between COVID-19 and vitamin D deficiency
(30:27) How Mendelian randomization studies helped solve the vitamin D puzzle
(34:20) The gene regulatory effects of vitamin D
(35:49) Vitamin D and the ACE2/renin-angiontensin system
(42:00) Daily doses of vitamin D are more effective
(43:23) A prescription-only form of vitamin D (calcifediol) may be best for COVID-19
(47:06) Skin synthesis of vitamin D from sunlight can be unreliable
(53:43) The safest dose range for vitamin D
(01:06:15) The beneficial circadian effect of early morning sunlight
(01:07:38) Sleep deprivation impairs vital immunity
(01:12:08) Dr. Seheult's suggestions for the best sleep
(01:19:18) A Spanish flu era treatment boosts interferon by ten times
(01:22:38) Why interferon is so important for the viral response
(01:26:43) Treating the symptoms of fever during the Spanish flu harmed patients
(01:31:58) Dr. Seheult's ongoing research of hot hydrotherapy
(01:47:00) COVID-19 Vaccines

If you're interested in learning more, you can read the full show notes.

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