Transcript
A (0:00)
Foreign
B (0:03)
welcome to Hacking youg adhd. I'm your host William Kerr and I have ADHD on this podcast. I dig in the tools, tactics and best practices to help you work with your ADHD brain. Today I'm joined by Sky Waterson for our Research Recap series. In this series, we look at a single research paper, dive into what the paper says, how it was conducted, and try and find any practical takeaways. In this episode, we're going to be discussing a paper called Evaluation of Maternal Inflammation as a Marker of Future Offspring ADHD Symptoms. A Prospective investigation. And so this is a study that is investigating like these biological origins of ADHD and you know, more specifically whether a mother's immune system during pregnancy might be able to predict ADHD symptoms in those children once they're born. So, yeah, it's pretty dense paper but, you know, I thought there was a lot here, so let's get into it.
A (0:54)
Yeah, and I will say it's great. This is why I love doing this, Will, because I so much appreciate that you are willing to go into this denser paper with me. And I want to say up front, when we're going through this paper, we are not experts in the medical field. And this particular paper is also very preliminary. So at the end it specifically references that the purpose of this paper is to decide what needs to be studied more in depth. So they looked at 68 children from 62 women who were pregnant in an outpatient clinic. And basically they wanted to understand if the biomarkers for inflammation in the second trimester were connected to symptoms of adhd, not ADHD diagnosis in later in life. And they were looking at that from teachers and also from the parents themselves. So there was a, it took quite a long time, this paper. It was, it was more of a longitudinal study.
B (2:02)
Yeah, absolutely. And I was really impressed with like, yeah, they were like looking at stuff with mother during pregnancy and then following up with those children who are born and like looking at those symptoms and being like, yeah, what are we seeing here? What, you know, like, because, yeah, you have to look at both that before and after effects and seeing what does. And that is, that's a long term study.
A (2:27)
100%. 100%. And what they were doing when they were doing those initial measures is they were measuring things like maternal distress, other things like this which can affect inflammation. And they did try and control for some of those. And then they were also looking at the, you know, blood samples and they were testing them to understand what the inflammation looked like. They said they couldn't draw the blood samples at the same time of the day for all participants. And we do know that inflammation can change due. Due to so many factors, including time of day. So I wanted to zoom out here a little bit, Will, and actually just say for those of those people who are listening and they're like, okay, cool, I've heard of inflammation, but. But what is it? What are we actually looking for?
