In this episode of The Histamine Well Podcast, Joanne takes a deep dive into MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci)—a frequently overlooked bacterial colonization that can drive chronic inflammation, histamine intolerance, and persistent, unexplained symptoms.

Joanne explains how MARCoNS colonize the nasal passages, often in the context of mould-related illness, and why these bacteria are particularly difficult to eradicate due to their ability to form protective biofilms. She explores the connection between MARCoNS and symptoms such as fatigue, brain fog, migraines, anxiety, poor detoxification, and heightened inflammatory responses, especially in individuals who don’t improve despite targeted gut or histamine protocols.

This episode walks listeners through how MARCoNS are identified, with a focus on nasal swab testing, and outlines evidence-informed treatment strategies, including biofilm disruptors, targeted herbal antimicrobials, and supportive therapies designed to reduce bacterial load and calm immune activation.

Whether you’re a health practitioner working with complex chronic cases or an individual struggling with ongoing symptoms that don’t fully resolve, this episode provides practical insight into MARCoNS as a hidden driver of inflammation and histamine dysregulation.

In This Episode, You’ll Learn:

What MARCoNS are and how they impact the immune system
Why MARCoNS are linked to chronic inflammation and histamine-related symptoms
Common signs and symptoms associated with MARCoNS colonization
How nasal swab testing is used to identify MARCoNS
Treatment approaches including biofilm disruptors and targeted antimicrobials

Joanne discusses laboratories that provide MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci) nasal swab testing, commonly used in clinical practice to identify bacterial colonisation linked to chronic inflammation, histamine-related symptoms, and mould-associated illness.

Nutripath (Australia): https://nutripath.com.au/
Microbiology Dx (USA): https://www.microbiologydx.com/

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