Podcast
Longevity Optimization with Kayla Barnes-Lentz
Hosted by Kayla Barnes-Lentz · EN
Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.
31episodes
Episodes
Newest firstAll episodes
Dr. Stephanie Riley Hahn: Pelvic Floor Optimization, Leaks, Sex, And Prolapse
Feb 2601:35:53Tap to summarizePelvic floor problems are not a “just do more kegels” issue.For a lot of women, kegels are either not specific enough, or they make symptoms worse.In this episode, Dr. Stephanie Riley Hahn, pelvic floor physical therapist and founder of Longevity and Pilates, breaks down what pelvic floor dysfunction actually is, how to tell weakness from tightness, and why pressure management and breathing mechanics often matter more than squeezing harder.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIn this conversation:Why pelvic floor tightness can drive pain, irritation and symptomsThe difference between weakness and tension, and how to tellHow breathing and pressure management change everythingWhat downtraining involves, and what tends to backfireProlapse support options, and when to seek helpOveractive bladder and constipation patterns that keep symptoms aliveConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...YouTube: www.youtube.com/@KaylaBarnesLentzFollow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about StephanieInstagram: https://www.instagram.com/longevityptpilates/Website: https://www.longevityptandpilates.com/Shownotes:Pelvic floor PT locator: https://www.aptapelvichealth.org/ptlocator
Transcribe →Dr. Aimie Apigian, MD: The Biology of Trauma + Nervous System Safety
Feb 1901:54:54Tap to summarizeLongevity isn’t just workouts, supplements, and recovery tools, it starts with nervous system health. In this episode, Dr. Aimie Apigian explains what trauma actually is (not a label, but a measurable physiological response), how the body shifts from stress into overwhelm, and why “pushing through” often turns into years of avoidance, numbing, and hidden internal strain.She breaks down the biology behind the trauma response, including the role of adrenaline, cortisol timing, and how mitochondrial capacity influences resilience. You’ll also learn her practical, body-based approach to creating “safe enough” in real time, plus the three phases of healing: safety, support, and expansion, so you don’t stay stuck avoiding triggers forever.In this conversation:Stress vs trauma response (and what changes physiologically)Why adrenaline drives the response and cortisol arrives laterHow the body stores trauma as patterns, not just memoriesThe 3 nervous system states and the thoughts they generateA simple somatic exercise to build safety in the bodyWhy devices/meds can be bridges, not the destinationUsing biomarkers + wearables without fooling yourselfWhy modern media can create vicarious traumaJoin the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/YouTube: www.youtube.com/@KaylaBarnesLentzSpotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Aimie Apigian, MD:Instagram: https://www.instagram.com/draimie/YouTube: https://www.youtube.com/c/DrAimieApigianWebsite: https://www.biologyoftrauma.com/Order her Book “The Biology of Trauma”: https://www.biologyoftrauma.com/book
Transcribe →I Became the First Woman in the World to Test Her Ovarian Age
Feb 1400:18:48Tap to summarizeFor the first time in history, ovarian biological age can be measured, and I became the first woman in the world to take the test.Until now, women have had no real way to understand how their ovaries are aging beyond rough estimates like AMH. But this new machine-learning algorithm, trained on over 40,000 real women across different life stages, analyzes hormone biomarkers, body composition, and reproductive history to estimate ovarian age relative to chronological age.This is a massive step forward in female longevity science.In this episode, I walk through what the test measures, how the algorithm works, and what becoming the first data point actually means, not just for me, but for women collectively. We also explore what may be driving ovarian aging in the first place.I also share how I’m now testing specific interventions in isolation, including hyperbaric oxygen therapy, to determine whether we can meaningfully influence ovarian aging over time.Ovarian lifespan is significantly shorter than overall lifespan and once we can measure it, we can begin to understand it.This is only the first step in redefining female longevity.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-member*Kayla's social + website:*Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comSpotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQApple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comSHOW NOTES:00:01:03 Timeless Biotech Website:https://timelessbiotech.com/00:01:13 Podcast With The Founder of Timeless Biotech:https://www.youtube.com/watch?v=s-_EuNUwjsM&t=57s00:04:12 Kayla’s Protocols:https://www.protocol.kaylabarnes.com/00:09:58 Podcast With Dr. Chris Masterjohn:https://www.youtube.com/watch?v=z3quYW_pCDU00:10:48 Study About Ovarian Stiffness Increasehttps://pmc.ncbi.nlm.nih.gov/articles/PMC7681059/#acel13259-sec-000200:16:22 Study For Increased PFAShttps://pubmed.ncbi.nlm.nih.gov/41620147/00:17:56 Red Light Therapy Study:https://www.sciencedirect.com/science/article/abs/pii/S1011134424001842?via=ihub
Transcribe →Cynthia Thurlow, NP: Perimenopause, Insulin Resistance and Midlife Metabolism
Feb 1200:58:49Tap to summarizePerimenopause is not just about hormones, it’s a metabolic transition that affects insulin sensitivity, gut health, stress tolerance, and long-term disease risk.In this episode, Cynthia Thurlow, board-certified nurse practitioner and functional medicine expert, explains how women’s metabolism changes in midlife and why insulin resistance, poor stress resilience, and gut dysfunction often appear years before menopause.She breaks down how perimenopause can begin earlier than most women expect, why symptoms vary so widely, and how lifestyle factors like fasting, exercise intensity, sleep, alcohol, and chronic stress interact with hormones during this transition.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberThis conversation explores:Why insulin resistance often emerges in perimenopauseHow stress and trauma shape metabolic and hormonal healthThe role of gut health in PMS, mood, and estrogen balanceWhen fasting helps women and when it makes things worseWhy “doing everything right” can still lead to symptomsHow to individualize nutrition, training, and recovery in midlifeConnect with Kayla:Instagram:https://www.instagram.com/kaylabarnes/TikTok:https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/YouTube: www.youtube.com/@KaylaBarnesLentzApple: https://podcasts.apple.com/us/podcast...Website:https://www.protocol.kaylabarnes.comLearn more about Cynthia ThurlowInstagram: https://www.instagram.com/cynthia_thurlow_/YouTube: https://www.youtube.com/cynthiathurlowWebsite: https://www.cynthiathurlow.com/Pre-order her upcoming book: The Menopause Gut (28th of April 2026):https://www.penguinrandomhouse.com/books/777129/the-menopause-gut-by-cynthia-thurlow-np/?mcp…ACE (Adverse Childhood Experiences) questionnaire:https://www.acesaware.org/wp-content/uploads/2022/07/ACE-Questionnaire-for-Adults-Identified-English-rev.7.26.22.pdf
Transcribe →Dr. Chris Masterjohn, PhD - Mitochondria, Micronutrients, and How Nutrition Actually Drives Longevity
Feb 502:39:42Tap to summarizeWhen cellular energy production is impaired, no diet, supplement, or health protocol can work as intended.In this episode, Dr. Chris Masterjohn, nutrition scientist and expert in micronutrients and metabolism, explains why mitochondrial function is the limiting factor behind stalled progress, persistent fatigue, and supplements that stop working over time.He breaks down why vitamin D supplementation often creates new problems when it is taken without proper nutrient balance, how high doses can disrupt other systems in the body, and why sunlight has biological effects that vitamin D pills alone cannot replicate.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberThis conversation explores:Why mitochondrial bottlenecks explain most energy and health plateausHow micronutrient deficiencies undermine supplements and biohacksWhen creatine supports cellular energy and why it works differently than most supplementsWhy vitamin D supplementation can backfire without context and balanceWhy sunlight affects biology in ways supplements cannot replaceHow diet, fasting, and exercise interact with mitochondrial capacityWhy optimizing one system often breaks another without proper foundationsConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr Chris Masterjohn’s work:Website: https://www.chrismasterjohn-phd.com/Instagram: https://www.instagram.com/chrismasterjohn/YouTube: https://www.youtube.com/@chrismasterjohn
Transcribe →Dr. Jessica Shepherd, MD – Menopause, Hormone Therapy and Bone Health
Jan 2900:49:13Tap to summarizeIn this episode, Dr. Jessica Shepard, board-certified OB/GYN and Chief Medical Officer of Hers, shares that the FDA just removed the black box warning on hormone replacement therapy after 23 years. We discuss what actually happened with the WHI study that created all the fear around estrogen and breast cancer, and why the research never actually supported that narrative.Dr. Shepard explains why you shouldn't wait until menopause to start the HRT conversation and how starting in your perimenopausal years can make all the difference for long-term health. Dr. Shepard shares the essential labs she runs on patients including ApoB, HbA1c, and thyroid optimization, plus the longevity metrics women should be tracking.We also get into supplement recommendations including why she recommends 10 grams of creatine daily, the role of inflammation in aging, and how estrogen is naturally anti-inflammatory which is why women see increased cardiovascular risk and metabolic dysfunction after menopause.Kayla's social + website:Instagram: kaylabarnesTikTok: femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comSpotify: https://open.spotify.com/show/4OLWWn2...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comDr. Jessica Shepherd's social + website:Website: https://www.jessicashepherdmd.com/Instagram: https://www.instagram.com/jessicashepherdmd/Transform Your Health: https://eudemonia.net/?utm_source=podcast&utm_medium=kayla-podcast&utm_campaign=jessica-shepherd
Transcribe →Dr. Khanh Nguyen - The Blood Swap: Why Doctors Are Replacing Your Plasma With THIS
Jan 2201:09:08Tap to summarizeWhat if your blood is what’s making you sick and the key to reversing it is removing it?In this episode, I sit down with Dr. Khanh Nguyen, a regenerative and anti-aging physician, to explore therapeutic plasma exchange and the rising use of young plasma. We talk detox, autoimmune disease, aging, peptides, and why your blood might be holding you back.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/...Kayla's social + website:Instagram: kaylabarnesTikTok: femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comSpotify: https://open.spotify.com/show/4OLWWn2...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comDr. Khanh's social + website:Instagram: https://www.instagram.com/regenwithdrnguyen/ Website: Austin Regenerative Therapy
Transcribe →Female Training and Exercise Protocols with Dr. Stacy Sims
Dec 12, 2024Tap to summarizeToday I’m speaking with Dr. Stacy Sims, a leading expert in exercise physiology and nutrition science, to delve into the unique physiological differences between men and women. In this episode, we explore how the menstrual cycle impacts women’s training and performance, and the critical need for personalized exercise regimens tailored to different stages of a woman’s life. Dr. Sims shares her groundbreaking insights on optimizing health and performance for women through science-backed strategies. Dr. Stacy Sims is an acclaimed researcher, author, and speaker specializing in women’s health and performance. Known for her mantra, “Women are not small men,” Dr. Sims focuses on empowering women with the knowledge to harness their physiology for optimal training, nutrition, and well-being. With years of experience in academia and practical application, she is a pioneer in redefining the approach to female-specific health and fitness. Follow Dr. Sims Here Chapters 00:00 Introduction to Female Health and Exercise 02:46 Understanding Female-Specific Physiology 05:54 Differences in Exercise Protocols for Women 09:04 The Impact of Menstrual Cycle on Training 11:58 Training Through Different Life Stages 14:49 Nutrition and Iron Needs During Menstruation 18:09 Building a Sustainable Training Routine 20:54 Creating a Community for Female Health Optimization 27:15 The Importance of Strength Training and Recovery 30:31 Training Cycles and Adaptation Strategies 32:21 Mobility and Stretching: Key to Injury Prevention 33:46 Empowering Women Through Compound Movements 36:34 Bone Health and Strength Training for Women 38:57 Nutrition: The Best Approach for Women 44:06 Recovery Modalities: Sauna and Cold Plunge Benefits 47:54 Sleep Needs and Circadian Rhythms in Women 50:40 Essential Supplements for Women's Health
Transcribe →Cancer Prevention with Dr. Leigh Erin Connealy, MD
Jun 27, 2024Tap to summarizeToday I am speaking with Dr. Leigh Erin Connealy, MD. Dr. Connealy is absolutely amazing, and I was so interested to have her on the podcast because of her incredible experience and philosophy on cancer prevention. We discuss cancer rates, what she recommends for preventing cancer, cancer early diagnostics, how she treats patients in her clinics and much more. If you are interested in joining my Female Longevity Optimization Group, learn more here: https://www.skool.com/femalelongevityoptimization/about About Dr Connealy: Leigh Erin Connealy, M.D. is a prominent leader in the field of Integrative Medicine. She utilizes the best of all sciences, including conventional, homeopathic, eastern medicine and modern medicine. She is the Medical Director of Cancer Center for Healing and Center for New Medicine. The combined 30,000 S.F. clinics have become the largest integrative medical clinic in North America, and have been visited by over patients 47,000 patients. Dr. Connealy's Website: https://www.connealymd.com/ Dr. Connealy's Instagram: https://www.instagram.com/connealymd/ Timestamps: 00:00 Introduction and Background 06:13 Taking a Holistic Approach to Healthcare 11:04 The Rise of Cancer and the Health of Children 31:39 Reducing the Risk of Cancer: Lifestyle Recommendations 32:09 Preparing the Body for Pregnancy and Raising Healthy Children 33:07 The Importance of Sleep, Water, and Reducing Plastic Use 35:21 Exercise and Mindful Eating for Optimal Health 37:18 Addressing Emotional Well-being and Trauma 46:19 Early Cancer Detection Methods: Full Body MRIs and Liquid Biopsies 52:30 A Comprehensive Approach to Cancer Treatment
Transcribe →Longevity Molecules with Dr. Kyle Gillett
May 22, 2023Tap to summarizeToday we welcome back my friend, Dr. Kyle Gillett. Today we are diving into all things longevity medicine and exogenous molecules that we can use to improve longevity. We discuss: HRT (hormone replacement therapy), Peptides, Metformin, Rapamycin, underrated supplements and so much more. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health. Dr. Gillett's Clinic Dr. Gillet on Instagram
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