Beyond the Calcium Score: Longevity & Your Own Stem Cells

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Dr. Khoshal Latifzai - Rocky Mountain Regenerative Medicine

Guest: Dr. Kal Khoshal, MD (Rocky Mountain Regenerative Medicine, Boulder, CO) Focus: Longevity, prevention-first diagnostics, and regenerative therapies (peptides, hormones, PRP, stem cells).

Origin story & model: After Dartmouth Med and a Yale EM residency, Dr. Khoshal left the ER due to burnout and the “band-aid” nature of conventional care. He built a cash-pay concierge clinic to spend 60–90 minutes with patients, run deeper diagnostics, and create long-term, prevention-focused plans. He does not bill insurance (patients keep catastrophic coverage), which lets him order better tests and avoid the admin churn.

Diagnostics that actually predict risk:

Starts from top U.S. mortality drivers (cardiovascular disease, diabetes, cancer, trauma in older adults) and then chooses biomarkers that best reflect true risk, repeating them multiple times per year and explaining results in plain English with written notes.
Cancer screening: uses blood tests that detect circulating tumor DNA (ctDNA) as an early, broad screen; positives are followed by imaging (often full-body MRI or targeted MRI/PET).
Heart disease: warns that calcium-score CT can miss early non-calcified plaque (common in 40s–60s). Prefers imaging that sees soft plaque before calcification.
Whole-body MRI: advocates this for catching issues (like leg artery disease) that localized scans miss—especially relevant to older adults.

Therapies & philosophy:

Tools include peptides, hormones, PRP, and stem cells, but only after foundations: exercise, nutrition, and social health—there’s no shortcut.
Stem cells: strongly prefers autologous (your own) cells that are culture-expanded in a sterile lab, stored, and used over time (IV for systemic repair; guided injections for joints/spine).

Cautions against routine allogeneic (donor/cord) cells due to immune reactions and potential long-term autoimmunity.
Banking earlier is better, but even older adults can benefit; he shared an 80-year-old scoliosis case that avoided major spine surgery after one procedure.
In-clinic process: mini-lipo harvest → lab isolation & expansion → cryostorage (annual maintenance fee ~$350).
Advises skepticism about overseas clinics and some cord-blood banks with variable quality/control.

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