Podcast
Peptides Explained
Hosted by John Garrett · EN
Peptides Explained breaks down the most talked-about peptides and GLP-1 medications in health, fitness, and longevity — including semaglutide, tirzepatide, BPC-157, TB-500, and more.
Hosted by Registered Nurse John Garrett, this podcast explains how these compounds work, why they’re popular, what the research shows, and the real risks and side effects — all in plain language.
No bro science. No hype. Just clear, foundational education.
For informational purposes only. Not medical advice.
For Research Peptides; Offlinepeptides.com/ref/johngarrett/
https://www.skool.com/peptides-explained-15
13episodes
Episodes
Newest firstAll episodes
I Asked ChatGPT to Build the Ultimate Peptide Stack... Here's What It Chose
2d ago00:13:09Tap to summarizeI asked ChatGPT a simple question... and the answer surprised me.For Research Grade Peptides, check out Offline Peptides 🌐 OfflinePeptides.com/Ref/JohnGarrettIf ChatGPT were a 47-year-old peptide researcher who needed to lose 40 pounds, had a nagging knee injury, wanted to preserve muscle, improve energy, and had an unlimited budget, what peptide stack would it choose?Instead of recommending every popular peptide on the market, it built a surprisingly logical plan focused on solving the biggest problems first.In this episode of Peptides Explained, we break down the science and reasoning behind each selection:RetatrutideBPC-157TB-500TesamorelinMOTS-cGHK-CuWe also discuss why several well-known peptides didn't make the list, why ChatGPT preferred individual peptides over a Glow Stack, and how prioritizing your biggest health challenge may be more important than simply taking more compounds.This episode is an educational thought experiment—not medical advice—and is designed to spark discussion about peptide science, mechanisms, and evidence.Powered by Peptide SolutionsLooking for peptide education, research resources, or provider-guided peptide options?🌐 https://peptide-solutions.infoFor Research Grade Peptides, check out Offline Peptides 🌐 OfflinePeptides.com/Ref/JohnGarrettAffiliate Disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you choose to use my affiliate link, I may earn a commission at no additional cost to you.
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Epitalon Explained: The Science of Telomeres, Aging & Longevity
4d ago00:13:16Tap to summarizeCan a peptide actually slow the aging process?In this episode of Peptides Explained, we take a deep dive into Epitalon—one of the most talked-about peptides in longevity medicine.You'll learn:What Epitalon is and where it came fromHow telomeres and telomerase workWhy the pineal gland may play a role in agingWhat the human and animal research actually showsWhy activating telomerase is both exciting and scientifically complexThe current FDA and regulatory status of EpitalonThe difference between promising mechanisms and proven clinical outcomesRather than relying on hype, we examine the available evidence and discuss what researchers know—and just as importantly, what they still don't know.New Segment – N=1: Your Real-World ResultsHave you used Epitalon or another peptide we've covered on the show?I'd love to feature your experience in a future episode.Record a 2–3 minute video sharing:• Which peptide you used• Why you decided to try it• Your results—positive, negative, or somewhere in between• Anything you learned along the wayEmail your video to:john@peptidesexplained.infoYour experience may be featured in an upcoming N=1: Your Real-World Results segment.This podcast is for educational purposes only and is not medical advice.
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SS-31 Explained: The FDA-Approved Mitochondrial Peptide
1w ago00:14:53Tap to summarizeSS-31 (Elamipretide) may be one of the most fascinating peptides ever developed.Unlike most peptides that work by activating receptors on the surface of cells, SS-31 targets the mitochondria—the cellular power plants responsible for producing energy.In this episode of Peptides Explained, we break down:✅ What mitochondria actually do✅ The role of cardiolipin in cellular energy production✅ How SS-31 works biologically✅ Why SS-31 received FDA Accelerated Approval in 2025✅ What Barth Syndrome is✅ The latest human clinical data✅ How SS-31 compares with MOTS-c✅ Whether repairing mitochondria before metabolic optimization makes biological senseWe'll separate proven science from speculation and discuss what remains investigational.This podcast is for informational purposes only and is not medical advice.Support the ShowPeptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.https://offlinepeptides.com/ref/JohnGarrett/For peptide education, provider resources, and information about compounded peptide options through licensed providers:https://peptide-solutions.info#PeptidesExplained #SS31 #Elamipretide #Forzinity #BarthSyndrome #Mitochondria #Longevity #MOTSc #Peptides
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Peptide Math Explained: Dose, Volume, Concentration & Reconstitution
2w ago00:12:35Tap to summarizeMost peptide users understand what peptide they want to use, but many struggle with the math behind vial size, reconstitution, concentration, units, volume, and medication calculations.In this episode of Peptides Explained, we break down the fundamentals of peptide math in plain English. You'll learn the difference between total vial contents and dose, what reconstitution actually means, why concentration matters, how syringe units can create confusion, and the medication calculation formula used throughout healthcare.Whether you're interested in GLP-1 medications, growth hormone secretagogues, BPC-157, TB-500, Tesamorelin, or other peptides, these mathematical principles apply across the board.Topics Covered:• Vial Size vs. Dose• Reconstitution Explained• Concentration Made Simple• Units vs. Volume• The D ÷ H × V Medication Calculation Formula• Common Mistakes Peptide Users MakeThis podcast is for informational and educational purposes only and is not medical advice.Support the Show:Visit Peptide Solutions:https://peptide-solutions.infoPeptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.https://offlinepeptides.com/ref/JohnGarrett/
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Melanotan I, Melanotan II & PT-141 Explained: The Tanning Peptides That Changed Sexual Medicine
2w ago00:10:09Tap to summarizeWhat do tanning peptides have to do with sexual medicine?More than you might think.In this episode of Peptides Explained, we explore the fascinating science behind Melanotan I, Melanotan II, and PT-141 (Bremelanotide). What began as research into skin pigmentation and UV protection unexpectedly led to the development of an FDA-approved medication for hypoactive sexual desire disorder.You'll learn:• How the melanocortin system works• The role of alpha-MSH in pigmentation and physiology• The differences between Melanotan I and Melanotan II• Why Melanotan II became known for effects beyond tanning• How PT-141 was developed from Melanotan II research• The clinical data behind pigmentation and sexual function• Potential side effects and safety considerations• The current regulatory status of these compoundsWhether you're interested in peptide science, dermatology, sexual health, or drug development, this episode highlights one of the most unexpected stories in modern peptide research.This podcast is for informational purposes only and is not medical advice.Learn more at:📍 Peptide-Solutions.infoResearch Peptide Affiliate Partner:📍 https://offlinepeptides.com/ref/JohnGarrett/Affiliate Disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.#PeptidesExplained #Melanotan #Melanotan2 #Melanotan1 #PT141 #Bremelanotide #PeptideTherapy #Longevity #HealthPodcast #MedicalScience
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Inside the Peptide Industry: Quality, Testing, Regulation & Grey Market Peptides
3w ago00:35:38Tap to summarizeThe founder of Offline Peptides joins Peptides Explained for a candid discussion about grey market peptides, quality control, regulation, and the future of the peptide industry.What are grey market peptides, and why have they become one of the fastest-growing topics in health, wellness, longevity, and performance?In this episode of Peptides Explained, host John Garrett sits down with Matthew Pacheco, founder of Offline Peptides, for an in-depth conversation about the current peptide landscape, quality control, consumer education, and the realities of the peptide industry.Together, they discuss why peptides have exploded in popularity, what consumers should know about third-party testing and Certificates of Analysis (COAs), the challenges facing the industry, and how the regulatory environment may shape the future of peptide access.This is not a sales pitch. It's an honest discussion about one of the most talked-about areas in modern health and wellness.TOPICS COVERED• What "grey market peptides" actually means• Why peptides have become so popular• Quality control and third-party testing• Understanding COAs and lab testing• Common misconceptions about peptides• Regulatory and FDA considerations• Consumer safety and education• The future of peptide research• The role of transparency in the peptide industryGUESTMatthew PachecoFounder, Offline PeptidesPEPTIDE RESOURCESPeptides Explained Podcast Websitehttps://peptidesexplained.comPeptide Solutionshttps://peptide-solutions.infoPeptide Solutions was created to help connect listeners with peptide education and peptide access pathways through trusted partners.OPTION 1: RESEARCH PEPTIDESOffline Peptideshttps://offlinepeptides.com/ref/JohnGarrett/OPTION 2: LICENSED PROVIDER & COMPOUNDED PEPTIDESPremier PharmacyFor clinicians interested in prescribing peptides in their practice, or individuals interested in speaking with a licensed healthcare provider regarding peptide therapies, visit:https://peptide-solutions.infoAFFILIATE DISCLOSUREPeptides Explained is an affiliate partner with Offline Peptides. If you use the affiliate link above, I may earn a commission at no additional cost to you.ABOUT PEPTIDES EXPLAINEDPeptides Explained is a podcast dedicated to helping listeners understand peptide science, mechanisms, clinical research, and real-world applications through evidence-based discussions and expert interviews.DISCLAIMERThis podcast is for informational and educational purposes only and is not medical advice. Nothing discussed in this episode should be interpreted as medical, legal, or regulatory guidance. Always consult a qualified healthcare professional regarding your individual health needs.#PeptidesExplained #OfflinePeptides #PeptideSolutions #Peptides #GLP1 #Retatrutide #Tirzepatide #Semaglutide #Longevity #Healthcare #MedicalEducation #FunctionalMedicine #WeightLoss #PeptideResearch
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KPV Explained: Gut Inflammation, Ulcerative Colitis, and the Science Behind the KLOW Blend
3w ago00:18:53Tap to summarizeIn this episode of Peptides Explained, we take a deep dive into KPV, a three-amino-acid peptide derived from alpha-melanocyte stimulating hormone (alpha-MSH) that has generated growing interest for its potential anti-inflammatory effects.We explore the biology behind KPV, how it may influence inflammatory pathways such as NF-kB, and why researchers have studied it in models of ulcerative colitis, Crohn's disease, inflammatory bowel disease (IBD), and intestinal barrier dysfunction.You'll learn:• What KPV is and where it comes from• How KPV may reduce inflammatory signaling• The role of PepT1 transporters in the gut• What animal and laboratory studies have shown• The limitations of current human data• Why KPV has become popular in gut health discussionsWe also examine the growing interest in the KLOW Blend, a combination of:• KPV• BPC-157• TB-500• GHK-Cuand discuss the scientific rationale behind combining these peptides to target inflammation, tissue protection, cellular migration, and regeneration.As always, we separate biological mechanisms from marketing claims and review what the evidence actually shows.Peptide Solutions is owned and operated by host John Garrett and helps educate both patients and healthcare professionals about peptide science and peptide therapy pathways.Learn more at:Peptide-Solutions.infoPeptides Explained is an affiliate partner with OfflinePeptides.com.If you use the link below, I may earn a commission at no additional cost to you:https://offlinepeptides.com/ref/JohnGarrett/Healthcare providers interested in prescribing compounded peptides and individuals interested in telehealth consultation options can learn more through Peptide Solutions.Visit:Peptide-Solutions.infoDisclaimer: This podcast is for educational and informational purposes only and is not medical advice. KPV and the KLOW Blend are not FDA-approved therapies, and much of the research discussed comes from laboratory and animal studies. Always consult a licensed healthcare professional regarding medical decisions.Powered By Peptide SolutionsResearch Peptide Affiliate DisclosureCompounded Peptide Information
Transcribe →Selank vs Semax: The Russian Peptides for Anxiety, Focus, and Brain Health
4w ago00:11:13Tap to summarizeIn this episode of Peptides Explained, we take a deep dive into two of the most talked-about Russian research peptides: Selank and Semax.We'll explore where these peptides came from, how they work in the brain, and why researchers have studied them for anxiety, stress resilience, cognitive performance, neuroprotection, and stroke recovery. You'll learn about key mechanisms involving GABA, dopamine, serotonin, BDNF, and neuroplasticity while separating scientific evidence from internet hype.We also review the available clinical data, discuss regulatory status in the United States, and explain what is known—and still unknown—about the safety and effectiveness of these compounds.Whether you're a clinician, researcher, peptide enthusiast, or simply curious about emerging neuroscience, this episode provides a balanced, evidence-based look at Selank and Semax.Topics Covered:• What are Selank and Semax?• Russian peptide research history• Anxiety and stress-response signaling• BDNF and neuroplasticity• Cognitive enhancement claims• Stroke recovery research• Safety considerations and limitations• Current regulatory statusSupport the PodcastPeptides Explained is powered by Peptide Solutions, owned and operated by John Garrett.For educational information about peptides and available options:Peptide Solutions: https://peptide-solutions.infoFor those interested in research-use peptides:https://offlinepeptides.com/ref/JohnGarrett/Affiliate Disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use the affiliate link above, I may earn a commission at no additional cost to you.This podcast is for informational and educational purposes only and does not constitute medical advice.
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Can Peptides Help Menopause? The Truth About Libido, Weight Gain & Aging
Jun 300:19:43Tap to summarizeIn this special episode of Peptides Explained, we're focusing on a topic that affects millions of women but often isn't discussed openly enough: menopause, hormonal signaling, libido, body composition, and the emerging role of peptides.Why does weight gain seem different during menopause? What causes the sudden changes in energy, sleep, skin, hair, and sexual desire? And where do peptides like Kisspeptin, PT-141 (Bremelanotide), Tesamorelin, GHK-Cu, BPC-157, and GLP-1 medications fit into the conversation?Join host John Garrett, RN, as he breaks down the science behind female hormone signaling in clear, understandable language. We'll explore the biology of menopause, the neurochemistry of desire, the "collagen cliff," metabolic changes, and the latest research on peptides being studied for women's health and aging.This episode covers:• Menopause and metabolic changes• GLP-1 medications and weight management• Kisspeptin and reproductive hormone signaling• PT-141 and female sexual desire• Tesamorelin and growth hormone pathways• GHK-Cu and collagen production• BPC-157 and recovery science• Oxytocin and emotional connection• What is evidence-based vs. what remains experimentalWhether you're navigating perimenopause, menopause, or simply interested in understanding how peptide science intersects with women's health, this episode delivers a balanced, evidence-based look at one of the most important conversations in modern medicine.Learn more:www.peptide-solutions.infoPodcast website:www.peptidesexplained.infoSupport the podcast and learn more about peptide research:offlinepeptides.com/ref/JohnGarrettAffiliate Disclosure: Peptides Explained is an affiliate partner with Offline Peptides. If you use my affiliate link, I may earn a commission at no additional cost to you.Follow Peptides Explained:• Instagram: @PeptidesExplained• Facebook: Peptides Explained• LinkedIn: Peptides Explained• Patreon: Peptides Explained• Skool: Peptides Explained CommunityIf you enjoy the show, please follow, subscribe, leave a review, and share this episode with someone who would benefit from understanding the science behind menopause, hormones, and peptide therapy.Peptides Explained is powered by Peptide Solutions, founded and operated by John Garrett, RN, providing education on peptide science and helping connect patients and clinicians with peptide-related resources.This podcast is for informational purposes only and is not medical advice.
Transcribe →GLP-1 Medications and the Brain | Mood, Anxiety, Motivation & Dopamine Explained
Jun 100:15:37Tap to summarizeGLP-1 medications may affect far more than appetite and weight loss.In this episode, we explore the growing evidence surrounding semaglutide, tirzepatide, and retatrutide and their potential effects on mood, anxiety, dopamine signaling, motivation, and compulsive behavior.We discuss both the research and the real-world patient reports clinicians are increasingly hearing in practice.
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