Podcast
Peptides Explained
Hosted by John Garrett · EN
Peptides Explained breaks down the most talked-about peptides and GLP-1 medications in health, fitness, and longevity — including semaglutide, tirzepatide, BPC-157, TB-500, and more.
Hosted by Registered Nurse John Garrett, this podcast explains how these compounds work, why they’re popular, what the research shows, and the real risks and side effects — all in plain language.
No bro science. No hype. Just clear, foundational education.
For informational purposes only. Not medical advice.
For Research Peptides; Offlinepeptides.com/ref/johngarrett/
https://www.skool.com/peptides-explained-15
20episodes
Episodes
Newest firstAll episodes
AOD-9604 Explained: Can a Growth Hormone Fragment Burn Fat?
4d ago00:18:13Tap to summarizeAOD-9604 is often marketed as the “fat-burning fragment” of human growth hormone. But what does it actually do, and did it work in human obesity trials?In this episode of Peptides Explained, John Garrett, RN, breaks down:• What AOD-9604 is and how it differs from full-length HGH• Lipolysis, lipogenesis, and beta-3 adrenergic signaling• Why animal studies looked promising• What the early human trials showed• Why the obesity-development program was discontinued• Whether AOD-9604 raises IGF-1• Regulatory status, risks, unknowns, and anti-doping concerns• A responsible framework for evaluating experimental fat-loss peptidesThe central takeaway: AOD-9604 has a plausible preclinical mechanism, but the available human evidence does not establish dependable, clinically meaningful fat loss.This episode is for informational purposes only and is not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any therapy.This episode is brought to you by Offline Peptides. If you are interested in Research Peptides Learn more at PeptidesExplained.info/OfflinePeptides.For more information about Peptide Solutions, visit Peptide-Solutions.info.Send your 2–3 minute N=1 video to john@peptidesexplained.info.
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SLU-PP-332 Explained: Exercise Mimetic or Experimental Hype?
6d ago00:15:23Tap to summarizeSLU-PP-332 is being promoted as an “exercise mimetic” that may increase fat oxidation, endurance, and energy expenditure. But it is not actually a peptide, it is not FDA-approved, and the most compelling evidence comes from cell and mouse research—not human clinical trials.In this episode, John Garrett, RN, explains estrogen-related receptors, mitochondrial energy metabolism, the published preclinical findings, the oral-bioavailability problem, potential risks, regulatory status, and the difference between mimicking selected exercise pathways and replacing physical exercise.This content is for education and discussion only and is not medical advice. SLU-PP-332 is an experimental research compound with no established human therapeutic use.Learn more: PeptidesExplained.infoPeptide Solutions: Peptide-Solutions.infoOffline Peptides: PeptidesExplained.info/OfflinePeptidesAffiliate disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.Send 2–3 minute N=1 videos to john@peptidesexplained.info.
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Why Boomers Are Living Longer But Not Healthier: Where Peptides May Fit Into Healthy Aging
1w ago00:15:38Tap to summarizeWhy are Americans living longer than ever before while spending more years battling chronic disease?In this episode of Peptides Explained, we explore one of the biggest questions in longevity medicine: the difference between lifespan and healthspan.You'll learn why muscle loss, metabolic dysfunction, chronic inflammation, mitochondrial decline, immune aging, and cognitive changes are major drivers of aging—and where peptide research may fit into each of these biological systems.We discuss several categories of peptides currently being investigated, including:• Growth Hormone Secretagogues (Tesamorelin, Ipamorelin, Sermorelin, CJC-1295)• GLP-1 and Metabolic Peptides (Semaglutide, Tirzepatide, Retatrutide)• Anti-Inflammatory Peptides (KPV, Thymosin Alpha-1, BPC-157)• Regenerative Peptides (BPC-157, TB-500, GHK-Cu)• Nootropic Peptides (Semax, Selank, Dihexa)• Mitochondrial Peptides (MOTS-c, SS-31, Epitalon)This episode discusses current science, emerging research, and where evidence is strong—and where it is still evolving.This podcast is for educational purposes only and is not medical advice.Sponsored by Peptide SolutionsLearn more:https://peptide-solutions.infoResearch Peptides (Affiliate):PeptidesExplained.info/OfflinePeptidesAffiliate Disclosure: Peptides Explained is an affiliate partner with Offline Peptides. #Peptides #HealthyAging #Longevity #GLP1 #Retatrutide #Semaglutide #BPC157 #MOTSc #Healthspan #PeptidesExplained
Transcribe →NAD+ and Cancer: What the Science Actually Says
2w ago00:18:24Tap to summarizeNAD+ is one of the most talked-about molecules in longevity and wellness. It is marketed for energy, mitochondrial support, cellular repair, brain fog, recovery, and anti-aging.But what happens when we bring cancer biology into the conversation?In this episode of Peptides Explained, we break down the relationship between NAD+ and cancer in clear, responsible language. NAD+ is essential for normal cellular function, DNA repair, mitochondrial energy production, redox balance, and immune signaling. But cancer cells may also rely on NAD+ metabolism to support growth, survival, DNA repair, oxidative stress control, and possible treatment resistance.This episode covers NAD+, NADH, NR, NMN, niacinamide, IV NAD+, NAMPT, PARP enzymes, DNA repair, cancer therapy, human evidence, preclinical evidence, and why active cancer or recent cancer changes the risk discussion.This is not a hype episode and not a fear episode. The real answer is context.NAD+ biology is real. The cancer concern is biologically plausible. The human evidence is incomplete.This podcast is for informational purposes only and is not medical advice. Always consult a licensed healthcare professional before considering any therapy, supplement, peptide, injection, or infusion.Peptides Explained is powered by Peptide Solutions.Learn more: peptide-solutions.infoAffiliate disclosure: Peptides Explained is an affiliate partner with Offline Peptides . If you use my link, I may earn a commission at no additional cost to you.PeptidesExplained.info/OfflinePeptides#NAD #NADPlus #NMN #NR #CancerBiology #LongevityScience #Mitochondria #DNARepair #NAMPT #PARP #PeptidesExplained #PeptideScience
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DSIP Explained: The Sleep Peptide That Science Still Can't Explain
3w ago00:08:29Tap to summarizeDescriptionCan a tiny peptide discovered nearly 50 years ago hold the key to better sleep?In this episode of Peptides Explained, we explore Delta Sleep-Inducing Peptide (DSIP)—one of the most mysterious compounds in peptide research. Unlike many peptides discussed today, DSIP has no confirmed receptor, conflicting clinical data, and decades of unanswered questions.In this episode you'll learn:✔️ What DSIP is✔️ How sleep is biologically regulated✔️ The fascinating history of DSIP's discovery in the 1970s✔️ Proposed mechanisms involving GABA, serotonin, dopamine, and the HPA axis✔️ Human and animal research findings✔️ Potential side effects and safety considerations✔️ Why DSIP is not FDA approved and why no major medical organization recommends it for insomnia or other sleep disordersThis podcast is intended for educational purposes only and is not medical advice.🌐 Peptide Solutionshttps://peptide-solutions.info🧬 Research Peptides (Affiliate Partner)PeptidesExplained.info/OfflinePeptidesIf you use my affiliate link, I may receive a commission at no additional cost to you.📧 N=1: Your Real-World ResultsHave you researched DSIP?Send a 2–3 minute video describing your experience to:john@peptidesexplained.infoYou may be featured in a future episode.#DSIP #SleepPeptide #Peptides #SleepScience #Insomnia #Longevity #PeptidesExplained #SleepResearch #Neuroscience #Biohacking
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5-Amino-1MQ Explained: NNMT, NAD⁺, and Fat Cell Metabolism
3w ago00:29:11Tap to summarize5-Amino-1MQ is often talked about in peptide circles, but it is not actually a peptide. It is a small-molecule NNMT inhibitor being studied for its potential role in nicotinamide metabolism, NAD⁺ biology, methylation, fat-cell function, insulin sensitivity, and liver metabolism.In this episode, John Garrett breaks down the proposed mechanism behind 5-Amino-1MQ, why people are discussing it for fat loss and body composition, and what the current research actually shows.The data is interesting, especially in preclinical studies involving adipocytes, diet-induced obese mice, glucose tolerance, insulin sensitivity, and fatty liver markers. But the human clinical evidence is still limited, and 5-Amino-1MQ is not FDA-approved for fat loss, obesity, metabolic disease, longevity, or body composition.This episode takes a balanced look at the science, the grey-market reality, and how to think about emerging metabolic compounds responsibly.This podcast is for informational purposes only and is not medical advice. Always consult a licensed healthcare professional before considering any therapy.Peptides Explained is powered by Peptide Solutions.Peptides Explained is also an affiliate partner with Offline Peptides. If you use my link, I may earn a commission at no additional cost to you.Offline Peptides affiliate link:https://offlinepeptides.com/ref/JohnGarrett/Podcast website:https://peptidesexplained.infoPeptide Solutions:https://peptide-solutions.info
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BPC-157 & TB-500 for Dogs: Healing, Recovery & the Science | Veterinary Series Ep. 1
3w ago00:21:44Tap to summarizeBPC-157 & TB-500 for Dogs: Healing, Recovery & the Current ScienceWelcome to Episode 1 of the Peptides Explained Veterinary Series.In this episode, we examine two of the most talked-about peptides in regenerative veterinary medicine—BPC-157 and TB-500.We'll discuss what researchers currently know about these experimental peptides, why they're generating interest among veterinarians and dog owners, how they may influence tendon, ligament, muscle, and connective tissue repair, and where the evidence remains limited.Whether you own an active family pet, a hunting dog, an agility competitor, or a working K9, this episode provides a balanced look at the science while separating evidence from online speculation.Educational only. BPC-157 and TB-500 are experimental compounds and are not FDA-approved veterinary medications.Learn more at https://peptide-solutions.infoPeptides Explained is an affiliate partner with Offline Peptides. If you use my link, I may earn a commission at no additional cost to you.https://offlinepeptides.com/ref/JohnGarrett/Have a real-world experience using peptides with your dog? Send a 2–3 minute horizontal video to john@peptidesexplained.info for a chance to be featured in our "N=1: Your Real-World Results" segment.
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I Asked ChatGPT to Build the Ultimate Peptide Stack... Here's What It Chose
4w ago00:13:09Tap to summarizeI asked ChatGPT a simple question... and the answer surprised me.For Research Grade Peptides, check out Offline Peptides 🌐 OfflinePeptides.com/Ref/JohnGarrettIf ChatGPT were a 47-year-old peptide researcher who needed to lose 40 pounds, had a nagging knee injury, wanted to preserve muscle, improve energy, and had an unlimited budget, what peptide stack would it choose?Instead of recommending every popular peptide on the market, it built a surprisingly logical plan focused on solving the biggest problems first.In this episode of Peptides Explained, we break down the science and reasoning behind each selection:RetatrutideBPC-157TB-500TesamorelinMOTS-cGHK-CuWe also discuss why several well-known peptides didn't make the list, why ChatGPT preferred individual peptides over a Glow Stack, and how prioritizing your biggest health challenge may be more important than simply taking more compounds.This episode is an educational thought experiment—not medical advice—and is designed to spark discussion about peptide science, mechanisms, and evidence.Powered by Peptide SolutionsLooking for peptide education, research resources, or provider-guided peptide options?🌐 https://peptide-solutions.infoFor Research Grade Peptides, check out Offline Peptides 🌐 OfflinePeptides.com/Ref/JohnGarrettAffiliate Disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you choose to use my affiliate link, I may earn a commission at no additional cost to you.
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Epitalon Explained: The Science of Telomeres, Aging & Longevity
4w ago00:13:16Tap to summarizeCan a peptide actually slow the aging process?In this episode of Peptides Explained, we take a deep dive into Epitalon—one of the most talked-about peptides in longevity medicine.You'll learn:What Epitalon is and where it came fromHow telomeres and telomerase workWhy the pineal gland may play a role in agingWhat the human and animal research actually showsWhy activating telomerase is both exciting and scientifically complexThe current FDA and regulatory status of EpitalonThe difference between promising mechanisms and proven clinical outcomesRather than relying on hype, we examine the available evidence and discuss what researchers know—and just as importantly, what they still don't know.New Segment – N=1: Your Real-World ResultsHave you used Epitalon or another peptide we've covered on the show?I'd love to feature your experience in a future episode.Record a 2–3 minute video sharing:• Which peptide you used• Why you decided to try it• Your results—positive, negative, or somewhere in between• Anything you learned along the wayEmail your video to:john@peptidesexplained.infoYour experience may be featured in an upcoming N=1: Your Real-World Results segment.This podcast is for educational purposes only and is not medical advice.
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SS-31 Explained: The FDA-Approved Mitochondrial Peptide
Jun 2400:14:53Tap to summarizeSS-31 (Elamipretide) may be one of the most fascinating peptides ever developed.Unlike most peptides that work by activating receptors on the surface of cells, SS-31 targets the mitochondria—the cellular power plants responsible for producing energy.In this episode of Peptides Explained, we break down:✅ What mitochondria actually do✅ The role of cardiolipin in cellular energy production✅ How SS-31 works biologically✅ Why SS-31 received FDA Accelerated Approval in 2025✅ What Barth Syndrome is✅ The latest human clinical data✅ How SS-31 compares with MOTS-c✅ Whether repairing mitochondria before metabolic optimization makes biological senseWe'll separate proven science from speculation and discuss what remains investigational.This podcast is for informational purposes only and is not medical advice.Support the ShowPeptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.https://offlinepeptides.com/ref/JohnGarrett/For peptide education, provider resources, and information about compounded peptide options through licensed providers:https://peptide-solutions.info#PeptidesExplained #SS31 #Elamipretide #Forzinity #BarthSyndrome #Mitochondria #Longevity #MOTSc #Peptides
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