Podcast
Pushing The Limits
Hosted by Lisa Tamati · EN
Pushing the limits - the show that gets deep into the psyche of limit pushers from all walks of life. Out the box thinker, elite athlete, successful entrepreneurs, social change innovators, scientists and more.
Cutting to the chase to find out what makes them so successful, how they did it, what their life philosophies are and what gems of wisdom they can impart to us all.
Hosted by Professional Adventure Athlete Lisa Tamati, author, producer, motivational speaker and mindset coach
30episodes
Episodes
Newest firstAll episodes
INUSpheresis: Removing Toxins, Heavy Metals & Microplastics From Blood/ Tash Simons
1w ago00:52:56Tap to summarizeWhat if the reason you're not getting better isn't about what you're putting in — but what you can't get out? In this episode I sit down with Tash Simons from INUSpheresis Perth — the first clinic in Australia and the Southern Hemisphere to offer this advanced blood filtration therapy. We go deep into how double filtration plasmapheresis works, the two specialised filters (TKM58 and INUS 30), and the science behind removing autoantibodies, inflammatory cytokines, heavy metals, microplastics, PCBs, and oxidised LDL directly from your blood — without involving your kidneys or liver. We cover the clinical research across long COVID, ME/CFS, autoimmune conditions, Lyme disease, Alzheimer's, and cardiovascular risk including Lp(a) — one of the hardest lipid markers to shift. Tash shares the personal story of how a family member's chronic fatigue led her and Dr Robbie Simons to discover this therapy in Vienna, and the journey to bring it to Perth — from TGA registration and insurance approvals to Swiss certification and over 100 treatments completed. If you're dealing with a chronic condition that won't budge, carrying a toxic load, or thinking about longevity from a subtractive medicine perspective — this one's for you. Book a consult or submit a new patient form at inuspheresisperth.com.au Check out my supplement store at shop.lisatamati.com Rejuvenate Pro at shop.lisatamati.com/pages/rejuvenate My books at shop.lisatamati.com/collections/books Sign up for my newsletter at www.lisatamati.com/lisa Listen to more episodes at www.lisatamati.com/ptl-podcast/ div]:bg-bg-000/50 [&_pre>div]:border-0.5 [&_pre>div]:border-border-400 [&_.ignore-pre-bg>div]:bg-transparent [&_.standard-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.standard-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8 [&_.progressive-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.progressive-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8"> _*]:min-w-0 gap-3 standard-markdown"> This episode is also brought to you by Rejuvenate Pro from Aevum Labs. If INUSpheresis is about taking the bad stuff out, Rejuvenate Pro is about protecting what stays behind. Featuring kawakawa, carnosic acid, Immunel colostrum extract and IDP (Immune Defense Protein), it targets the chronic systemic inflammation that silently drives aging. It's the first supplement in every protocol I build for my clients — and it should be in yours. Shop now at shop.lisatamati.com/pages/rejuvenate ━━━━━━━━━━━━━━━━━━━ 🌐 Website: https://www.lisatamati.com 🛒 Supplements: https://shop.lisatamati.com 📧 Contact: support@lisatamati.com ━━━━━━━━━━━━━━━━━━━━
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Copper, Mitochondria Grey Hair & Autism: The Missing Link No One Is Talking About
2w ago00:52:02Tap to summarizeCould a simple mineral deficiency be driving mitochondrial dysfunction in autism? In this episode I sit down with Melissa Atchley from MitoSynergy to hear her personal story of using BioCopper1 with her son on the autism spectrum — and the changes she saw that no one expected. I break down the science behind it: Dr Richard Frye's research showing Complex IV dysfunction in children with ASD, the brand new April 2026 Science Advances paper linking copper deficiency directly to ASD-like behaviours through mitochondrial damage and impaired myelination, and why the type of copper matters — Cu1+ vs Cu2+ — more than most people realise. We also cover MitoSynergy's new MitoActivator MAX (4x the strength of the standard formula), the hair greying reversal angle, athletic performance benefits, and practical dosing guidance. If you or someone you love is navigating autism, fatigue, grey hair, or just wants to understand why copper might be the most overlooked mineral in health — this one is worth your time. Get yours in my shop: https://shop.lisatamati.com/products/mitoactivator-max-max-strength-biocopper1-supplement-60-capsmitosynergy-mitoactivator-max?_pos=2&_sid=5c471c21c&_ss=r Or use code LisaTamati at Mitosynergy.com for your discount
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Klotho, Peptides & Limitless Longevity — Dr. Alex Grinberg & Dr. Dave Jenkins
3w ago01:00:22Tap to summarizeThese two doctors are building a clinic where the most advanced longevity therapies have no limits. Dr. Alexander Grinberg (Infinity Epigenetics, San Francisco) and Dr. Dave Jenkins (Bredesen-trained, 40+ years clinical experience) are combining peptide therapy, regenerative medicine, and personalised protocols at a level most people don't know exists. From Klotho protein restoring cognitive function in head injury patients to mitochondrial peptides that can rescue dying cells — this conversation covers the cutting edge of what's actually possible right now. About the Guests Dr. Alexander Grinberg MD is a physician, immunologist, and peptide therapy specialist practicing in San Francisco. He holds a fellowship from the Moscow Immunology Institute and consults internationally on advanced customised longevity protocols. He runs Infinity Epigenetics and teaches physicians in high-end integration of peptides, regenerative medicine, and genetic therapies. Dr. Dave Jenkins is a New Zealand-trained physician with 40+ years of clinical experience specialising in metabolic and neurological health. He is Bredesen Protocol (ReCODE) trained and runs a longevity clinic in Bali. He co-developed a Type 2 Diabetes reversal program now being published and reviewed by NZ's top diabetic specialists. In this episode Why Klotho protein may be one of the most powerful longevity interventions available — and the different delivery forms (protein injection, peptide fragments, gene therapy) Dr. Dave's clinical Klotho results: a doctor with chronic head injury returning to practice, and his own memory score jumping from the 66th to the 97th percentile in six weeks How mitochondrial peptides (MOTS-c, SS-31, Humanin) work and why dosing wrong can be dangerous — especially in autoimmune and cancer history cases The case for micro-dosing peptides and why skin testing should come first Personalised medicine taken to its extreme: harvesting a patient's own cells, expanding them in culture, and running accelerated longevity and cancer resilience tests before any intervention Why peptide purity and sourcing is a serious safety concern — and what the clinic will do differently The vision for a Pacific Island longevity clinic offering therapies unavailable in the US, EU, NZ, or Australia — with a social impact mission to address metabolic disease in local populations Off-label repurposed drugs for cancer (metformin, ivermectin, doxycycline, mebendazole) and why the regulatory environment matters How custom peptides designed from a patient's own genome could replace pharmaceuticals entirely Resources mentioned Infinity Epigenetics — infinityepigenetics.com Dr. Dave Jenkins — 🌐 https://youngerbyscience.com/ 🌐 https://theendofalzheimers.com
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The 7 Reasons Your Cells Age (And How to Stop It) Dr Sandra Kaufmann
4w ago01:20:57Tap to summarizeYour cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. 👉 FREE Longevity Cheat Sheet — subscribe to my weekly newsletter: https://www.lisatamati.com/lisa/ Description: Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Dr Sandra Kaufmann is a cell biologist, physician, and creator of the Kaufmann Protocol — the first comprehensive rating system for anti-aging supplements. In this episode she shares the off-label drugs, supplement stacks, and cellular strategies she uses daily to slow aging at the molecular level. We go deep on mast cell activation and its connection to aneurysms and heart attacks, why NAD infusions may be doing more harm than good, the three sirtuins you need to prioritise after 40, why she takes 70 supplements and 13 medications at low doses, and the SGLT2 inhibitor drugs that are regrowing healthy heart cells by clearing senescent zombie cells. This is one of the most important longevity conversations I have had on the show. ⏱️ TIMESTAMPS: 0:00 - Teaser: Senolytic drugs that regrow healthy heart cells 0:20 - Welcome and intro to Dr Sandra Kaufmann 1:38 - Sandra's background: cell biologist to longevity expert 3:14 - The Post-it note office and chasing the aging puzzle 8:33 - The Seven Tenets of Aging overview 10:19 - Tenet 3: Sirtuins, AMPK, mTOR, and circadian rhythms 11:54 - Tenet 4: DNA repair, proteostasis, autophagy 13:07 - Deep dive: Mast cells and tissue destruction 14:16 - Mast cells, heart attacks, and aneurysms 17:43 - Mastering the Mast Cell: Sandra's new publication 21:06 - Stress triggers mast cell degranulation 23:04 - Mast cell stabilisers: supplements and drugs 27:17 - Sirtuins 1, 3, and 6: the keys to cellular homeostasis 30:05 - Best activators: pterostilbene, DHM, fucoidan 33:38 - The NAD debate: NMN vs NR vs infusions 36:23 - Why NAD IV infusions are a bad idea 39:06 - Rotating NAD precursors: Sandra's approach 44:52 - NRF2 pathway and why daily glutathione is a mistake 50:05 - 70 supplements and 13 drugs at low synergistic doses 56:50 - Rapamycin: Sandra says no 57:51 - Metformin: 250-500mg not 2000mg 1:00:16 - The Flozins: glucose excretion plus senolytic activity 1:02:32 - Epalrestat: blocking the glucose to fructose conversion 1:04:41 - Sandra's 5 daily eye drops protocol 1:08:13 - Naringenin, nobiletin, and the orange peel stack 1:11:28 - Supplement roundup and the Kaufmann Rating System 1:15:23 - Where to find Dr Sandra Kaufmann SPONSOR MESSAGE This episode is brought to you by MitoSynergy. If you are looking for next-level mitochondrial support, MitoSynergy delivers bioavailable copper in a patented form that supports energy production at the cellular level. Head to mitosynergy.com/lisaTamati and you will get 10% off your order. And if you have not tried Re:juvenate Pro yet, this is the supplement I formulated with my biotech company Aevum Labs. It is not another NAD supplement. Re:juvenate Pro targets immunosenescence, the aging of your immune system, which sits upstream of so many of the problems Sandra and I discussed today. It contains kawakawa, carnosic acid, Immunel colostrum extract, and Immune Defense Protein working across multiple pathways including NRF2 activation, gut barrier support, and immune modulation. It is the first thing I put in every client protocol and it is what I give my mum every single day. You can grab it at https://shop.lisatamati.com/pages/rejuvenate 🔗 LINKS MENTIONED IN THIS EPISODE: Website: kaufmannprotocol. Website: kaufmannprotocol.com Clinical practice: kaufmannlongevity.com Instagram: instagram.com/kaufmannantiaging Books: amazon.com/stores/Dr-Sandra-Charlotte-Kaufmann/author/B07BDL1WV8 E-treatise: Mastering the Mast Cell (search Amazon) Club Exosome: quarterly in Las Vegas with Steve McCain ━━━━━━━━━━━━━━━━━━━━ 🌐 Website: https://www.lisatamati.com 🛒 Supplements: https://shop.lisatamati.com 🎙️ Podcast: https://www.lisatamati.com/podcast 📧 Contact: support@lisatamati.com ━━━━━━━━━━━━━━━━━━━━ About Lisa Tamati: Longevity specialist, functional health practitioner, co-founder of Aevum Labs (home of Rejuvenate Pro), and host of Pushing The Limits — a globally top-200-ranked health podcast. Author of 4 books.
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The One System Behind ALL 14 Hallmarks of Aging — And How to Target It | Courtney Van Bussum
Apr 2401:18:31Tap to summarizediv]:bg-bg-000/50 [&_pre>div]:border-0.5 [&_pre>div]:border-border-400 [&_.ignore-pre-bg>div]:bg-transparent [&_.standard-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.standard-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8 [&_.progressive-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.progressive-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8"> _*]:min-w-0 gap-3 standard-markdown"> Your immune system isn't just fighting off colds. It's the foundational system that influences all 14 hallmarks of aging — and when it declines, everything downstream accelerates. In this episode, I sit down with Courtney Van Bussum, COO of Longevity Launch Labs, to dive deep into immunosenescence — the aging of the immune system — and why it starts far earlier than most people realise. We unpack what Stanford's landmark 1000 Immunomes Project revealed about the real driver of biological aging, why your supplement stack might be missing the most important piece, and how we built Re:juvenate Pro (Cell Restore in the US) to target immune aging at its root. We get into the fire station analogy that makes the immune system finally make sense, why 70-80% of your immune system lives in your gut and what that means for barrier health, the science behind four synergistic ingredients — Immune Defense Protein, Immunel colostrum extract, carnosic acid from NZ rosemary, and kawakawa — and why standard colostrum supplements aren't cutting it. We also cover why NSAIDs are impairing your recovery, what CXCL9 is and why most practitioners have never heard of it, Isobel's lymphocyte count recovery story, the immune age calculator app, and why "boost your immune system" is the wrong approach — modulation is everything. This is not another colostrum product. This is upstream immune intervention. Links: Shop Re:juvenate Pro (NZ): https://shop.lisatamati.com/pages/rejuvenate Aevum Labs: https://aevumlabs.co.nz Cell Restore (US practitioners): https://aevumlabs.us Cell Restore (US patients): https://ohphealth.com Longevity Launch Labs: https://longevitylaunch.com Lisa's books: https://shop.lisatamati.com/collections/books Longevity newsletter: https://www.lisatamati.com/lisa More episodes: https://www.lisatamati.com/ptl-podcast/
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Reverse Alzheimers with Dr Dave Jenkins
Apr 1100:41:14Tap to summarizeWhat if you could know 20 YEARS before symptoms appear whether you're heading for Alzheimer's? And what if there was a proven way to reverse early cognitive decline? In this episode, I sit down with my dear friend Dr. Dave Jenkins — the leading Dr. Dale Bredesen Protocol practitioner in the Southern Hemisphere — to unpack the p-Tau 217 blood test revolution and the stunning results from Bredesen's latest randomised controlled trial. Dr. Dave breaks down how a simple finger-prick blood test can now detect the Alzheimer's process with 95% certainty up to TWO DECADES before memory symptoms begin. This isn't diagnosing Alzheimer's — it's diagnosing the process, which means you have 20 years to intervene. We dive into Bredesen's 2024 multi-site RCT showing the ReCODE precision medicine protocol is 6–7x MORE POWERFUL than the best Alzheimer's drug currently available in America (lecanemab) — a drug with devastating side effects including brain bleeds and even death. Dr. Dave shares real clinical insights from his Bali longevity practice including the 30–60 "holes in the roof" driving cognitive decline, cutting-edge peptides (Semax, Selank, Cerebrolysin, Dihexa), bioregulators, and his personal experience with Klotho gene therapy that took his memory scores from the 70th to the 97th percentile in just 6 weeks. This is essential listening for anyone with a family history of Alzheimer's, anyone watching a loved one decline, and anyone who wants to take brain health seriously BEFORE it becomes a crisis. ⏰ CHAPTERS: [to be generated after edit] 🧠 IN THIS EPISODE: ✅ The p-Tau 217 blood test — detect Alzheimer's 20 years early ✅ Bredesen's RCT: 6–7x more powerful than lecanemab ✅ The BrainScan panel: p-Tau 217, NfL, GFAP explained ✅ Why amyloid drugs chase the smoke, not the fire ✅ The 30–60 "holes in the roof" driving cognitive decline ✅ APOE4 genetics — who needs to pay attention ✅ Peptides for brain health (Semax, Selank, Cerebrolysin, Dihexa) ✅ Klotho gene therapy — 70th to 97th percentile memory scores ✅ Dr. Dave's Bali longevity program at Ravivo Resorts ✅ How NZ/AU listeners can access testing remotely 🔗 CONNECT WITH DR. DAVE JENKINS: 🌐 youngerbyscience.com 🌐 endalzheimers.com.au 🔗 RESOURCES MENTIONED: 🧬 BrainScan p-Tau 217 Test — neurocode.com 🧠 Dr. Dale Bredesen / Apollo Health — apollohealthco.com 📄 Bredesen 2025 RCT — apollohealthco.com/rct-2025 💊 EPISODE SPONSOR: MitoSynergy BioCopper1 — Get 10% off at mitosynergy.com/lisatamati The patented copper nicotinate chelate I take daily for mitochondrial ATP production, mental clarity, and sustained focus. 🔗 WORK WITH LISA: 🌐 lisatamati.com 🛒 shop.lisatamati.com 🧬 aevumlabs.co.nz 🎙️ Pushing the Limits Podcast — lisatamati.com/podcast 📧 support@lisatamati.com 📱 FOLLOW LISA: Instagram: @lisatamati Facebook: @lisatamati
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Robots in Healthcare: Tesla Optimus, Terafab - Cern Basher
Apr 201:12:06Tap to summarizeThe global healthcare system is heading for a catastrophic workforce shortage — 10 to 15 million workers short by 2030. In this episode, financial analyst and Tesla expert Cern Basher (@cernbasher) returns to break down how humanoid robots like Tesla's Optimus could be the only scalable solution, why New Zealand is uniquely positioned to lead a healthcare robotics pilot, and what the Terafab chip factory and Digital Optimus mean for the timeline. From fleet learning to the privacy concerns, from Moxy robots already in 25+ US hospitals to Elon Musk's vision of billions of robots powered by space-based AI — this is the conversation that healthcare, tech, and policy leaders need to be having right now. IN THIS EPISODE: The global healthcare workforce crisis — why no recruitment drive can fix it Robots already in hospitals: Moxy's 1M+ deliveries across 25 US hospitals Tesla Optimus: where the technology is right now The three components: physical body, AI brain, and language model Fleet learning explained — 40 robots learn in 6 months what takes a human 25 years Why New Zealand is the ideal proving ground for healthcare robotics Digital Optimus and Macrohard: the software robot that runs businesses Terafab: Tesla's $25B chip factory with SpaceX and xAI This episode is sponsored by MitoSynergy Copper 1+ Most copper supplements use poorly absorbed oxidised forms that can actually increase free radical damage. MitoSynergy's patented BioCopper1 (Cunermuspir) is a copper-niacin chelate that delivers reduced copper (Cu1+) directly to your mitochondria, supporting ATP production at cytochrome c oxidase. I've been personally testing MitoActivator EX and have noticed a real difference in training power and energy output. Try it: https://mitosynergy.com/lisaTamati (10% off with this link) ABOUT CERN BASHER: NZ-born financial analyst and one of the most influential voices on X at the intersection of AI, Bitcoin, Tesla, and macroeconomics. Follow Cern: @cernbasher on X and YouTube -------------------------------------------- PTL SIGNAL — AI, Tech, Bitcoin and Markets: https://ptlsignal.com Free founding member access to our AI-powered Financial Document Analyzer — earnings transcripts, annual reports, Fed minutes analysed in 60 seconds. Take control of your health and unlock the secrets to a longer, healthier and more vibrant life: https://www.lisatamati.com/healthspan-hacks-course/ SHOP Longevity Supplements: https://shop.lisatamati.com -------------------------------------------- PODCAST — Pushing The Limits: https://www.lisatamati.com/podcast https://podcasts.apple.com/nz/podcast/pushing-the-limits/id1207975008 https://open.spotify.com/show/6mc5BfQispXYMxd4AaYXYL FOLLOW LISA: Instagram: @lisatamati X/Twitter: @lisaytamati YouTube: @LisaTamati Enquiries: support@lisatamati.com Website: www.lisatamati.com Shop: shop.lisatamati.com PTL Signal: ptlsignal.com
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Robots In Healthcare: Why This Changes Everything For The Future Of Medicine
Mar 2700:28:07Tap to summarize🔬 This episode is sponsored by MitoSynergy Copper 1+ Most copper supplements use poorly absorbed oxidised forms that can actually increase free radical damage. MitoSynergy's patented BioCopper1 (Cunermuspir) is a copper-niacin chelate that delivers reduced copper (Cu1+) directly to your mitochondria, supporting ATP production at cytochrome c oxidase. I've been personally testing MitoActivator EX and have noticed a real difference in training power and energy output. 👉 Try it: https://mitosynergy.com/lisaTamati (10% off with this link) -------------------------------------------- New Zealand has a once-in-a-generation opportunity to position itself at the front of the humanoid robotics revolution — but nobody's talking about the real safety, privacy and cybersecurity concerns. In this video I break down why NZ should be aggressively pursuing Tesla and robotics in healthcare, the genuine risks around humanoid robots in personal spaces, and why the countries that get involved early don't just get the economic upside — they get to write the rules. 🎯 IN THIS VIDEO: → Why NZ could transform its economy with robotics in healthcare → The 5 real safety concerns about humanoid robots in personal spaces → Physical safety: the fall problem and force-limiting technology → Cybersecurity: what happens when someone hacks a walking camera → Privacy: the robot secretly sending data to China every 5 minutes → The teleoperation problem — strangers controlling robots in your home → Why there are NO safety standards yet for home robots → How NZ can shape global robotics regulation instead of inheriting it → The healthcare pilot approach: why hospitals first, homes later → First-mover advantage: NZ as the proving ground for humanoid robots 📺 RELATED EPISODES: → AI Just Broke The Economy — Cern Basher Part 1: https://www.youtube.com/watch?v=eh0hKibH6Zs → Tesla's Building A Robot Army — Cern Basher Part 2: https://www.youtube.com/watch?v=eh0hKibH6Zs → Why Tesla, Bitcoin & AI Are Moving Together — Cern Basher: https://www.youtube.com/watch?v=QzRPBLa2_Do&t=9s -------------------------------------------- 🔬 SPONSOR: MitoSynergy Copper 1+ Patented BioCopper1 (Cunermuspir) — delivers reduced copper directly to your mitochondria for ATP production, energy, mental clarity, and healthy ageing. Not your average copper supplement. 👉 https://mitosynergy.com/lisaTamati (10% off) -------------------------------------------- ➡️ Take control of your health & unlock the secrets to a longer, healthier & more vibrant life: https://www.lisatamati.com/healthspan-hacks-course/ 🛒 SHOP Longevity Supplements: https://shop.lisatamati.com Lisa's Ai, Tech, Crypto and Investing Website www.ptlsignal.com -------------------------------------------- 🎙️ PODCAST — Pushing The Limits: 🎧 https://www.lisatamati.com/podcast 🎧 https://podcasts.apple.com/nz/podcast/pushing-the-limits/id1207975008 🎧 https://open.spotify.com/show/6mc5BfQispXYMxd4AaYXYL 📱 FOLLOW LISA: Instagram: @lisatamati X/Twitter: @lisatamati YouTube: @LisaTamati Facebook: /lisatamatiultrarunner 📧 Enquiries: support@lisatamati.com 🌐 Website: www.lisatamati.com 🛒 Shop: shop.lisatamati.com #TeslaOptimus #RobotsInHealthCare #HumanoidRobots #NewZealand
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Wall Street Macro Investor Reveals: HRV, Longevity, Bitcoin & The AI Revolution | Jordi Visser
Mar 1801:21:35Tap to summarizeWall Street veteran and macro investor Jordi Visser spent 30 years managing billions in risk — building turbulence models to predict market crashes before they happened. Then he turned that exact same framework on his own biology. The result? He raised his HRV from the high 20s to the 60s over six years. Not with a protocol. With a system. Jordi is back on Pushing The Limits for round two and this episode covers everything. We go deep on HRV and longevity — what your wearable is actually telling you, why your gut health is the foundation of your HRV, why breathwork beats meditation, why muscle is a signal organ not just a performance tool, and how to use AI as a daily thinking partner to accelerate your health journey. Then we flip to macro. Jordi breaks down why he believes capitalism's 10,000 year bargain between capital and labour officially broke in 2025, why Bitcoin is the architectural blueprint for what comes next, why AI agents cannot operate without crypto infrastructure, and what the Strait of Hormuz crisis means for oil, commodities and your investments right now. We also get into the AI revolution and what it means for ordinary people — why entrepreneurs will beat Google, why you don't need to be technical to benefit from AI, how to build multiple income streams using these tools, and why leaning in now is the most empowering thing you can do for your financial future. This is one of the most wide ranging conversations we have ever had on Pushing The Limits. Health, wealth, technology and the future — all connected by the same framework. Topics covered include heart rate variability, HRV and longevity, resonance frequency breathing, the gut brain vagus nerve axis, muscle and ageing, fermented foods and the microbiome, AI tools for entrepreneurs, Bitcoin 2026, macro investing, the private credit crisis, Strait of Hormuz oil shock, commodities bull market, hardware stocks and why 2008 can never happen again. Find Jordi Visser at visserjhrv.substack.com for his HRV Substack and visserlabs.substack.com for his macro AI and Bitcoin research. His YouTube channel is at youtube.com/@JordiVisserlabs and he heads AI Macro Nexus Research at 22V Research. Find out more about Lisa and her work at lisatamati.com. Shop longevity supplements including Re:juvenate Pro at shop.lisatamati.com. Re:juvenate Pro is Aevum Labs flagship longevity formula targeting immunosenescence, inflammageing, gut health and cellular repair — co-developed with Dr Elizabeth Yurth of the Boulder Longevity Institute. Learn more at aevumlabs.co.nz. Pushing The Limits is available on all major podcast platforms. Subscribe and leave a review if this episode added value to your life. REJUVENATE PRO — AEVUM LABS: Our flagship longevity formula targeting immunosenescence, inflammageing, gut health and cellular repair. Co-developed with Dr Elizabeth Yurth of the Boulder Longevity Institute. NZ made, science backed, no fillers. Shop now: https://shop.lisatamati.com/pages/rejuvenate LONGEVITY SUPPLEMENT STORE: Everything Lisa personally uses and recommends: https://shop.lisatamati.com WORK WITH LISA: Functional health practitioner consultations for complex cases: https://www.lisatamati.com/page/work-with-lisa LISA'S BOOKS: https://www.lisatamati.com/page/books FREE NEWSLETTER AND LONGEVITY CHEAT SHEET: https://www.lisatamati.com/lisa/ WEBSITE: https://www.lisatamati.com PODCAST: https://www.lisatamati.com/podcast CONTACT: support@lisatamati.com FOLLOW LISA: Instagram: https://www.instagram.com/lisatamati Facebook: https://www.facebook.com/lisatamati YouTube: https://www.youtube.com/lisatamati X: https://x.com/lisatamati
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The Dark Side of NMN Nobody Tells You About
Mar 1200:45:58Tap to summarizeIs your NAD+ supplement actually working against you? Millions of people are taking NMN or NR thinking they're doing something smart for their longevity. And the science behind NAD+ is genuinely extraordinary. But the way most people are supplementing it is incomplete — and there's growing evidence it could be creating downstream harm most people never connect back to their supplement. In this episode I break down the full NAD+ story — the methylation trap, the CD38 drain, why high-dose NMN may be elevating your cardiovascular risk markers, and what an intelligent systems-level approach actually looks like. I co-developed NAD+ Next Gen with Peter Lehrke— and in this episode I walk you through exactly why every ingredient is in the formula. WHAT WE COVER: - The 2023 Nature Cardiovascular Research findings on NMN & ADMA - How high-dose NMN drains your SAM pool and disrupts dopamine, DNA methylation and homocysteine - CD38 — the biggest NAD+ drain in ageing nobody talks about - The bathtub model: precursors, drains, sirtuin efficiency - Why niacinamide may be smarter than high-dose NMN - EGCG, resveratrol, apigenin, quercetin, rutin — the why behind each ingredient - 6 practical takeaways including which blood test to get now KEY LINKS: NAD+ Next Gen → https://aevumlabs.co.nz Rejuvenate Pro → https://shop.lisatamati.com Pushing The Limits community → https://www.lisatamati.com GET YOUR HOMOCYSTEINE TESTED: Optimal: below 7–8 µmol/L Above 10 µmol/L: address your methylation cycle urgently Lisa Tamati is a functional health practitioner, longevity specialist, co-founder of Aevum Labs, host of Pushing The Limits, and former elite ultra-endurance athlete with 25 years and 140+ ultramarathons across the world's most extreme environments. Visit Lisa's website www.lisatamati.com shop.lisatamati.com www.longlifehyperbarics.com www.aevumlabs.co.nz www.Yourhealthcompass.org www.Myimmuneage.life Work with Lisa:
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