Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it.

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Description: Your cells start failing at 35.

Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it.

Dr Sandra Kaufmann is a cell biologist, physician, and creator of the Kaufmann Protocol — the first comprehensive rating system for anti-aging supplements.

In this episode she shares the off-label drugs, supplement stacks, and cellular strategies she uses daily to slow aging at the molecular level. We go deep on mast cell activation and its connection to aneurysms and heart attacks, why NAD infusions may be doing more harm than good, the three sirtuins you need to prioritise after 40, why she takes 70 supplements and 13 medications at low doses, and the SGLT2 inhibitor drugs that are regrowing healthy heart cells by clearing senescent zombie cells.

This is one of the most important longevity conversations I have had on the show.

⏱️ TIMESTAMPS: 0:00 - Teaser: Senolytic drugs that regrow healthy heart cells 0:20 - Welcome and intro to Dr Sandra Kaufmann 1:38 - Sandra's background: cell biologist to longevity expert 3:14 - The Post-it note office and chasing the aging puzzle 8:33 - The Seven Tenets of Aging overview 10:19 - Tenet 3: Sirtuins, AMPK, mTOR, and circadian rhythms 11:54 - Tenet 4: DNA repair, proteostasis, autophagy 13:07 - Deep dive: Mast cells and tissue destruction 14:16 - Mast cells, heart attacks, and aneurysms 17:43 - Mastering the Mast Cell: Sandra's new publication 21:06 - Stress triggers mast cell degranulation 23:04 - Mast cell stabilisers: supplements and drugs 27:17 - Sirtuins 1, 3, and 6: the keys to cellular homeostasis 30:05 - Best activators: pterostilbene, DHM, fucoidan 33:38 - The NAD debate: NMN vs NR vs infusions 36:23 - Why NAD IV infusions are a bad idea 39:06 - Rotating NAD precursors: Sandra's approach 44:52 - NRF2 pathway and why daily glutathione is a mistake 50:05 - 70 supplements and 13 drugs at low synergistic doses 56:50 - Rapamycin: Sandra says no 57:51 - Metformin: 250-500mg not 2000mg 1:00:16 - The Flozins: glucose excretion plus senolytic activity 1:02:32 - Epalrestat: blocking the glucose to fructose conversion 1:04:41 - Sandra's 5 daily eye drops protocol 1:08:13 - Naringenin, nobiletin, and the orange peel stack 1:11:28 - Supplement roundup and the Kaufmann Rating System 1:15:23 - Where to find Dr Sandra Kaufmann

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🔗 LINKS MENTIONED IN THIS EPISODE: Website: kaufmannprotocol. Website: kaufmannprotocol.com Clinical practice: kaufmannlongevity.com

Instagram: instagram.com/kaufmannantiaging

Books: amazon.com/stores/Dr-Sandra-Charlotte-Kaufmann/author/B07BDL1WV8

E-treatise: Mastering the Mast Cell (search Amazon)

Club Exosome: quarterly in Las Vegas with Steve McCain

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About Lisa Tamati: Longevity specialist, functional health practitioner, co-founder of Aevum Labs (home of Rejuvenate Pro), and host of Pushing The Limits — a globally top-200-ranked health podcast. Author of 4 books.