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Savannah Boda
Hi, guys. Welcome back to another week of the Bondis podcast. I am your host, Savannah Boda.
Tyler Jacoby
I'm your co host, Tyler Jacoby.
Savannah Boda
And we have a very special friend, a mentor, a friend, a sister, colleague, the queen of everything, Jacqueline Watchmaker. We're so excited to have you here. We first met her in LA. How many years ago? Two. Two years ago? Yeah, I think it was two years ago.
Tyler Jacoby
20. 23. Yes, it was like right after or right before your wedding.
Savannah Boda
And I was like, how can you be so young and beautiful and a doctor and have gone through all of the lives that you've lived and like, still look so flawless and be so cool? Like, she is the coolest.
Jacqueline Watchmaker
Oh, my gosh, you're too sweet. I think the same thing about you.
Savannah Boda
Stop it. We love you. And she truly is amazing. So I'm going to let her introduce herself and kind of tell you a little bit about her background. And today we're going to be talking a lot about BioRewind, which is Skin Butter's new supplement, which Dr. Watchmaker helped conduct the clinical studies. She did a lot of education for it. So she is like, if you want to know the nitty gritty about this, she is the source.
Jacqueline Watchmaker
So thanks so much for having me on. I'm Jacqueline Watchmaker. I am a board certified dermatologist and I mostly do esthetic dermatology. So a lot of lasers, skin care, I mean, injectables as well. And I love talking about skin care, using skin care. I love working with skin better and I think they're a great company because they really, you know, invest in the clinical research behind their products. And I've been had the opportunity to work on some of the clinical trials with them. So I'm happy to be here.
Savannah Boda
I'm so excited. And she did the clinical trials as well for Maestro. She's done a ton. But Maestro I thought was one of the coolest that she's done. And just honestly, I think out of the whole portfolio of skin better besides Alpharette, I would say Maestro is like probably the most innovative and best results that I see and just really big changes in people's skin.
Jacqueline Watchmaker
I love Maestro and all my friends, family, all the nurses I work with, everyone loves it. And I always say it's like the only product I used consistently twice a day.
Tyler Jacoby
No, it is phenomenal, I think especially dramatic results. Like, that's the thing, it's like you can use the product for like two weeks. Like a crazy difference.
Jacqueline Watchmaker
Yeah, I love it and I always. So I Actually just had a clinical trial patient who was in the Meister study come in this morning. And like, once they see the results and, you know, are in the clinical trial, they like, I hear them all the time coming back for more. And that's not always the case. Sometimes with clinical trials, if you try a new product, they'll use it for the duration of the study and then they kind of give up. But like, very consistently, the patients, you know, my own patients, but also the study patients, they see the results and they want to continue it, which I think speaks highly of that product.
Savannah Boda
It does. And I think one of my favorite things, and I've quoted you a lot on this, is that you said, Maestro, you see better results at that Ferrarisacea and redness and a lot of topicals that you would typically prescribe for your patients for rosacea, which is a huge statement and really is factual. I mean, I've had clients that were on prescription things for a very, very long time for rosacea. Nothing quite calmed and subdued their rosacea the way Maestro did.
Jacqueline Watchmaker
Yeah, I love it for all rosacea patients, but even patients who don't have rosacea, and I love that it's like, you know, a botanical blend. So I think patients also feel safe and comfortable using it long term, unlike some of, you know, the other things that we sometimes need for rosacea. But yeah, love it.
Savannah Boda
I love that. Okay, so tell us dummy version. If somebody has never. Well, not dummy, because why would we want to go dummy when we have the expert here? But like, basics of what BioRewind is. What is glycation? What are ages like pretend I have never heard any of this before.
Jacqueline Watchmaker
Okay, so BioRewind is basically an anti glycation supplement. It's a supplement that helps improve skin health by preventing glycation and reversing glycation that's already there. And very basically it uses different extracts of rosemary, this like proprietary core extract to achieve this. But if we're talking about what is glycation, that does get a little sciency.
Savannah Boda
Yeah, go sciencey. We're ready.
Jacqueline Watchmaker
It's a non enzymatic, so it doesn't use. It doesn't need an enzyme to make this process occur in the body. But it's a non enzymatic reaction that occurs in the body when a sugar and sugars can be. The most common one we think about is like glucose in the body and a protein or a lipid. And proteins in the body that a lot of people are familiar with are like collagen when they react and kind of bind together. And when this sugar and this protein react and combine together, that process is called glycation. And then kind of the end final product result of that glycation reaction is something called an advanced glycation end product. Or we call them ages for short. And those age, you can think of them as being like inflammatory and destructive throughout the body. They can basically go anywhere. I know with biorewind we talk about it primarily, you know, are almost exclusively in the context of the skin. But glycation occurs in all of our organs throughout our body, including our skin. The skin, I think it's good that we talk about it mostly because the skin is very prone to glycation and the effects of these damaging age for a few reasons. One, the kind of collagen and a lot of different components of the skin don't actually turn over as quickly as other cells in our body do. And also UV damaged sunlight contributes to glycation and the formation of these advanced glycation end products. So the skin kind of has a double whammy of why it really is prone to glycation. But all of our organs can have glycation. And I know I've mentioned this before, but as far as talking about glycation, an extreme example is a diabetic patient. And I think a lot of people know people who have diabetes and they have eye issues, they have kidney issues, they have skin issues, they basically have nerve issues, they have issues throughout their body. And the primary driver is advanced glycation end products. And that is because people with diabetes have super high levels of glucose circulating throughout their body. So that glucose and the proteins throughout their body are reacting and basically damaging their organs. So in everyone, even people without diabetes, there is some low level of glycation happening all the time. And it's, it is one of the primary drivers of kind of why you age. So having kind of a tool, even for healthy young people, you know, everyone has some glycation and having a tool to kind of reverse and prevent that to some degree, I think is really powerful.
Savannah Boda
Yeah, and I think the coolest thing is like, you know, glycation. I've heard the term thrown around in my like, skincare journey, but I've never really dove deep into it until this, like, it's always kind of just been like something you hear about but not really talked about because there wasn't a lot that could be done. Like there are things that can kind of help stop from furthering or getting worse, but there was nothing to actually reverse the Damage that already occurred. And that I think is like, what is so important for those clients that are in their 50s and 60s and they've had this glycotive damage for years and years and years. And it's like, okay, yeah, we can, with other products, stop it from getting worse, but what about if we turn back the time and actually start to, you know, peel that glue off of those proteins and give it a chance, you know, to come back to normal and in a more healthier state? So I think it's so amazing. And I've had such good feedback already from clients that are taking it now. It's been out for what, two months now or maybe a month and a half. But I had a client literally only four weeks, and she was like, I literally look younger. Like, I can see a difference. And her confidence has boosted, like glow redness, like, all of those things have improved. So it's pretty amazing. And I think, you know, people, when we talk about supplements, a lot of stuff out there can be gimmicky, A lot of stuff can be, you know, not FDA regulated. And, you know, people are just make all these claims. But the thing I really appreciated about this specifically and Skin Butter, like, I trust this company more than I trust my husband because they are just so ethical and honest about everything they do, like, every step of the way. There are a lot of skincare companies out there, guys that are scammers or trying to just get a quick buck or, you know, harping on things. But Skin Butter has never been that way. Like, if you knew the founder, Jonah, I've met him thousands of times. He calls me on my birthday every year like he is just a good human being. And Jaclyn has a very close relationship with him too. The way he's. And why I think Skin Butter has been so successful is not only because the products are amazing, but they're not just going to throw something out there just for fun or just for money or for profit. Like, they're really focused on making things that no one's done before and enhancing things that have already been done to make them different, more stable, more tolerable, and kind of just rewriting the skincare industry as a whole. Like, nobody can really keep up with them. Like, they just keep on pumping out things that were, like, never could even fathom happening. So anytime they have a new product launch, I'm like, I don't even have a first thought about what it could be be, because it's always something that, you know, they find a problem and Skin Better's method is like, okay, here's a problem. How can we fix it? So I think it's really just this product has been so cool.
Tyler Jacoby
Well, I think another thing about Skin Better is, and you talked about this earlier, but, like, the clinical backing they have for every single one of their products. And, you know, I feel like so many times we encounter in this space companies that say they have clinical studies, clinical data, but then you dig a little bit deeper, and it's like they had a pool of eight people that they tried it on, two dropped out, and they're like, these are the results. And you're like, well.
Savannah Boda
And as a normal esthetician, you wouldn't know these things. You know, like, I did not. I think a lot of my education came from working with Skin Better closely because they kind of peeled back the layer of, like, consumerism for me. And, like, I didn't just see, like, you know, oh, here's a product. Like, I got to see, like, kind of the back end of, like, how much goes into acquiring a technology and, like, then putting it into a formulation and just like, you know, the clinical studies, the testing, and, you know, just regulations and just so many, like, nitty gritty things that, like, I would never have known about. And so I don't fault any esthetician for that because, again, like, you want to trust your rep, you want to trust these companies, but a lot of it is smoke and mirrors, and a lot of it doesn't have any clinical testing or third party testing. So, Jaclyn, I want you to kind of talk about this study because it is so, so special. This is their most robust study that they've done. And, you know, way more about this because she's the one doing it. I just hear about it after the fact.
Tyler Jacoby
Yeah, that's what I. That's what I was trying to segue to is like, what is the difference between double blind placebo study versus like, someone doing. We have eight patients over here and they tried it. It was great.
Jacqueline Watchmaker
No, I totally agree with you guys. And I think. I mean, estheticians, but even dermatologists sometimes, you know, reps come in and they, like, you know, show a few before and after, sometimes with different lighting. And, you know, they never tell you, oh, this was nine patients. And I think it's easy to, like, look at a beautiful before and after of one patient and be like, oh, this really works.
Savannah Boda
But I think my favorite is the reps being like, this is my personal photo at my house, in my bathroom, like, girl, like, come on, give me something better.
Jacqueline Watchmaker
We need Visio. We need. Yeah. Double blind standardization. No, totally. And I think. But unless you know what questions to ask and what to like, look for when kind of like dissecting data from skin care companies, you don't. You only have to go off of what the reps tell you. And they're obviously trying to sell a product. So. But yeah, I think asking the right questions and knowing what to look for in studies is like so important when evaluating, you know, studies and clinical results. But yes, you're right. This product was like six years in the making. There was kind of, this study was kind of a two part study. It was a double blind, randomized clinical trial. And double blind means the doctor who was dispensing the product didn't know if it was the actual supplement or if it was just kind of a placebo supplement. The supplements looked the same. They actually did like a capsule within a capsule. So it's not like, you know, someone was taking a little, you know, sugar pill and someone was actually getting the, you know, real capsule. It was, they looked the exact same to both the doctor who was giving the study patients the supplement and then also the patients didn't know if they were taking the actual supplement or the placebo. So that's what the double blinded part means. And then the study, the patients took kind of two to two, so two capsules three times a day initially, then two and two, and then maintained one capsule in the morning and one capsule a night. And it was a 12 week long study. There was over 100 participants in the study. So it was like huge. And they looked at tolerability, safety, they obviously looked at clinical endpoint from both the patient's perspective, the investigators perspective, but also what makes this study really stand out. And this is the second component of the study is they did biopsies from the arm of a subset of patients and they sent these to a different lab. It was actually, I think in Italy. And they had blinded, you know, people in the lab look at the studies and they looked at different markers in the skin and from patients who were on the placebo and patients who are actually on the supplement. And they looked at different kind of oxidative stress markers as well as different markers that like looked at advanced glycation end products and in the. And it's important that it was blinded because, you know, I think there is some placebo effect in any study. But the people who received these biopsy samples were completely blinded. They didn't know if they were looking at a biopsy from the placebo group or from the supplement group. And they found that both the oxidative stress markers and the advanced glycation end product markers were improved in the patients who were on the actual supplement and not the placebo. So I think that's really, really powerful data to have. The investigator who was blind did see an improvement in the patient's results. The patients who were on the supplement saw an improvement based or compared to the placebo group. And then this other lab also saw an improvement on the biopsy samples. So I think it was like a very elegantly done study and all of the data points to, you know, that this product really does work.
Savannah Boda
That's amazing. Yeah, I never knew like, I thought when people like, oh, we have like white papers, like explain that because I used, that used to throw me for a loop when like, oh yeah, we have like white papers. What is a white paper? What does that mean?
Jacqueline Watchmaker
White papers you always have to, you take with a little grain of salt. They're like usually industry sponsored papers that basically I don't believe they're peer reviewed. So basically like, and I'm pretty sure this is correct, but basically, you know, they're usually it's good data but it's not like someone else is outside and like reviewing. Yeah, this to ensure it's accurate. And I also think these papers by skin better were published like in, you know, a peer reviewed journal. White papers you can kind of just put out.
Tyler Jacoby
It's like marketing materials basically.
Jacqueline Watchmaker
Yeah, it's like scientific marketing material. They're not bad and you can learn some good things from them. You do have to kind of look at them, I think with a, you know, a different lens than papers that are actually published in actual, you know, medical journal.
Savannah Boda
No, that makes sense. Yeah. There, it's crazy to me. There are like so many things I feel like in the industry that we just, you know, with some, you know, we see changes in our patients. So like, hey, we don't need like a clinical study on it. But I think what was so important with this like such a big claim like reverse glycation has never been said before, never been done before. That's a big thing to say. So that's, it's important that they did their due diligence and you know, invested so much in these studies and got them peer reviewed and made sure they were non biased and all the things to prove the results. And it's honestly to me one of those products that has really changed the industry. And I Think it's hard for some people to grasp the concept now because it's so new. And I feel like skin butter does that with so many things. Like, it took Alpharet such a long time for people to comprehend that I used to get so much backlash. You can't say that. That's not true. There's no such thing as a retinoid that isn't irritating or you can't have retinoic acid in your practice. It has to be prescribed and all the things.
Tyler Jacoby
You can't use an aha.
Savannah Boda
Yeah. Or you can't use an aha with a retino. Like, just so many things. Or you can't use a vitamin C with the retinoid. And you can with Skin Better. So I think it's just really cool how they've kind of gone against the grain and like, just shown, you know, through science that in results and studies that, you know, you can do these things and, you know, skincare in the skincare world and what we have access to and how we can amplify results has changed so much than back in the day. Because I feel like for a really long time before Skin Better, I feel like everything was just so boring. Like, it was like everyone was kind of doing the same thing and skin butter was like, okay, let's shake this up. Like, how can we make this industry better and bring more science and technology? And, you know, we're really lucky that Jonah, like, had the money and the funding for it, because a lot of these lines, like, it's hard to start a skincare line. It's hard to acquire technologies if you don't have money. So that's why most of the lines, you know, we see, you know, they're good, but, like, you really gotta have some capital backing to, like, make products like skin better.
Jacqueline Watchmaker
Yeah, 100%. And they're not going to, like you said before, just put anything out. There's like so much thought and behind the scenes kind of work that goes into it.
Savannah Boda
I wanted to ask you, with Maestro, how many times did they try to do a formulation? I can't remember the number. I know I knew it at one point. I know, like 96 times or something like that.
Jacqueline Watchmaker
It was something crazy. And I tested more than one formulation as well, kind of in our clinic. And they just kept going back to the drawing board until it was like, perfect.
Savannah Boda
Perfect. Because that was what. How many years was that one?
Jacqueline Watchmaker
How many years in the making was it? I'm not exactly sure, but more than one, for sure. I worked on it for, I think, a good year before it came to market. And I know it. Obviously, people were working on it before it even kind of got brought to me. Clinical trials, so amazing.
Tyler Jacoby
Yeah.
Jacqueline Watchmaker
They, like. And. And, you know, I think it takes so much time and energy to every single formulation. And I think some companies would be like, oh, it's good enough. Like, we've spen. Spent enough time, We've spent enough money.
Savannah Boda
Let's just, like, get it to market.
Jacqueline Watchmaker
Yeah. And they are like, no, like, let's go back. Let's.
Savannah Boda
Let's redo it until it's refining foam cleanser. I'm just kidding. That was not a formulation issue. That was. The cap was just not capping.
Jacqueline Watchmaker
Oh, yeah.
Savannah Boda
But it's not pumping.
Jacqueline Watchmaker
Obsessed with the new one. I actually just ran out this morning.
Savannah Boda
I know. It is so good. I. I think it took me a bit to adjust because I was just such.
Tyler Jacoby
She was the biggest oxygen.
Savannah Boda
I mean, like, that was my child. Like, I literally thought it was. Like, when Michelle called me and was like, have some news for you. Like, I was hoping it was a death and not death of oxygen wash.
Jacqueline Watchmaker
The death of oxygen Wash. Yeah. I mean, I loved oxygen wash too.
Savannah Boda
But I was like, you're kidding. I was like, no, that has to be a joke. Like, that was her telling me, like, trio was gone. I was like, oh, yeah.
Tyler Jacoby
Personally, I like refining foam better. Oxygen wash was too strong for me, but.
Savannah Boda
Okay. So here was my thing on that with him is he's on, like, a bunch of Actives already. For someone like me who really doesn't use a lot of Actives, like, it was great because that was like. Like all I really needed, you know, that and Alpharette. And Alpharette. Yeah.
Jacqueline Watchmaker
Yeah. I like both. But I. I might be with Tyler on this one a little bit.
Savannah Boda
He's a big refining foam fam. I'm getting there. You know, it's just like when you miss your ex, but, like, more time with the new boy, like, you start to realize, like, maybe he's better. I don't know. But then at night, you, like, kind of dream about your ex. That's about oxygen wash. I'm like, just one more time we could be together. Um, okay, so tell me, what were the biggest things or what are some of the biggest things that glycation can show on the skin? Like, what are, like, some of the, like, markers that you see and you can tell, like, okay, someone's experiencing this.
Jacqueline Watchmaker
Yeah. You can kind to think of, like, an extreme example of glycation I like to think of like an old smoker or like, oh, you know, Caucasian woman in their 60s who's been chain smoking for years.
Savannah Boda
Mom. Oh.
Jacqueline Watchmaker
If you look at their skin, there's pigmentation, there's like sallowness, which is like kind of like a yellow discoloration. It's just not bright. They're kind of puffy, there's wrinkles. So like, that's obviously the extreme example. But everyone, even people who are young and healthy and eat healthy and don't smoke, they'll have some component of kind of those markers of glycation, be it pigmentation or dullness or some puffiness or a little bit of that kind of like yellow aged sallowness. So all glycation can contribute to kind of all of that. Also glycation. And those unbiased glycation end products are inflammatory. And as we know with the skin, anything that causes, you know, inflammation can cause the skin, you know, barrier to not function optimally. It can cause some redness and inflammation in the skin. There's so many different skin conditions like acne and rosacea and even somewhat melasma that has inflammation kind of at its core. So this product, I think can kind of globally help the skin and any skin disease process that has inflammation associated with it, which honestly is everything. Everything. Yeah, I would potentially be helped with this. Of course, Skin Better hasn't studied it and, you know, a subset of patients with rosacea or with acne or anything like that, so the company can't make any claims. But just from my perspective, I think it would be able to help, help anyone struggling with kind of like any skin concern. And also I love, you know, it's a supplement. So we always, you know, talk about our face skin, sometimes our neck skin, but the supplement is systemic, so it's, you know, affecting all of our skin. So I have so many patients, even in their socially, like late 30s, 40s, who are starting to notice like, you know, just the skin on their, you know, chest and arms and even like their knees isn't as like bouncy and youthful and vibrant as it used to be. And I do think this is a, you know, that's sometimes hard to moisturize and put active all over your whole body. So I think this is like a really great, relatively easy way to kind of address your whole skin health. Not just your face, obviously your face too.
Savannah Boda
I love that. What were you gonna say?
Tyler Jacoby
Oh, no, I just said, well, wow.
Savannah Boda
My question, and I know they didn't study this and it's like, you can't claim this, but just from your brain and understanding the dosing of this, do you feel like it could help with the organs and all over glycation more than just the skin?
Jacqueline Watchmaker
I do. I mean, obviously, I'm saying that from my standpoint, and not skin butter.
Savannah Boda
Jacqueline, watchmaker, not skin butter included. I'm saying this.
Jacqueline Watchmaker
Yeah.
Savannah Boda
Yeah.
Jacqueline Watchmaker
I mean, again, I don't like anecdotal evidence because it's not helpful, but.
Savannah Boda
Yeah.
Jacqueline Watchmaker
I have been taking bioeon for, I think, over six months now, and I just went to my primary eye care doctor, and I. People who know me, I'm not, like, the beacon of health. I love Taco Bell. I mean, I work out a. Like, I'm good with sunscreen, but, like, diet, especially. Like, I ate three scoops of ice cream last night.
Savannah Boda
Like, I'm a. I like, you live your life, baby. I'm the same way. I ate Domino's last night, and I.
Jacqueline Watchmaker
Like, got all my labs drawn, and my PCP was like, wow, I haven't seen, like, labs this good in, like, a really long time. And I was like, I eat Taco Bell, like, once every week. Is that okay? And she literally was like, double it. Do whatever you want.
Savannah Boda
That's amazing.
Jacqueline Watchmaker
Whatever you're doing, keep doing it. Because, like, you're. She was like, based on your labs.
Savannah Boda
Like, you're the epitome of health.
Jacqueline Watchmaker
Yeah. And I mean, I have to think. And again, totally, we can't make any claims in this, but, like, I do think it probably is helping. It is helping more than just our skin.
Savannah Boda
Yeah. And of course, skin butter is studying it for the skin, but that's kind of what I was thinking, too. And with the rosemaric acid as well, my esthetician. Her. Well, not my esthetician, but, like. Like, the girl that works for me, that's my esthetician. Her mom started taking it, and not only her skin, but her hair has grown so much. Like, her hairdresser is like, you have to come get your grays covered like, once a week now.
Jacqueline Watchmaker
Yeah.
Savannah Boda
Crazy.
Jacqueline Watchmaker
Yeah. I think it has, like, potential benefits, like, way outside of what's been studied, but I'm excited, continue to learn more, especially as it's been out longer, and.
Savannah Boda
Hopefully more people get their hands on it. Yeah. I think that's so important.
Tyler Jacoby
I have a question, because I am not as deep in as y'all are. So when it comes to glycation, was this always, like, a big topic, or was this, like, kind of a smaller Topic because there was nothing you could do that you could do. Or is this something. I mean, I'm sure maybe in more of the medical side when it came to like diabetes or stuff like that. But I'm, I guess in relation to skin health was glycation, Like, I think.
Jacqueline Watchmaker
And I know, Savannah, you said it's.
Savannah Boda
Like kind of tossed around, but it never was like a huge thing and.
Jacqueline Watchmaker
That honestly, like, I go to a ton of dermatology conferences. Like, if people are going to talk about it, I'm going to hear about it. And it in the dermatology world too. It's been talked about a little bit, it's been thrown around a little bit, but it's not like people are going on stage or giving talks, like specifically on glycation, at least not often. I do think it is kind of in the world of dermatology, something that over the past, you know, five years is now just kind of getting more traction and there's more data and more, you know, studies being done, like you mentioned in kind of like the diabetes, Alzheimer's, more kind of systemic medical space. It's obviously been studied a lot, but like, the focus on skin I think is relatively newer. And so I'm excited for it to kind of continue and yeah, more studies to be done on it because I do think it's like an under discussed but very important topic.
Savannah Boda
Yeah. And honestly, I think the coolest thing about it is like, sadly, like me included and the majority of the population, like our like, inner health could be like, and we'll care more about like our hair and our skin. So I think like, just people that would take it out of, you know, more vanity side of, like, okay, I want to start taking this supplement for my skin. Actually could end up helping their health long term too. Like, of course that wasn't studied how it can help the other organs. But like, I mean, come on, kind of put two and two together. Like, it's gonna help everything. My opinion. So I think that's really cool. I think that's kind of getting people's like a little shoe in the door. Because of course, like, we're always like, what do we see first? We don't worry about the consequences of what's happening inside our body because we can't see it. But if we see our skin and we're worried about that or worried about like the aging effects of it, we're more likely to take it. I mean, I know that's how I am. Like, I'll take a supplement for that before I'll take a supplement or anything for like my headache or like gut health or anything. Like, like literally my me getting forehead acne was like what started me getting a probiotic in my body. So I was like, anything else, I didn't care. I'm like, my constant diarrhea, it's fine. The second my forehead starts breaking out, I'm like, probiotic today. So I think that's amazing. Okay, we have a couple minutes left. So I wanted to ask you about the biotin because that's been, I think when it first came out was a little bit of like people were worried about it type of thing. And then now that it's been out, I feel like, and I've said a million times how I feel about it, it's kind of died down. So why did they add biotin? Is it going to cause acne? For acne prone people, what is the recommended daily value and comparing it to like Nutrafol, what are your thoughts?
Jacqueline Watchmaker
It's like the tiniest little sprinkle. It's like the tiniest little whiff. Like I think, I think in, by everyone. It's like 3 micrograms if I'm not mistaken. And in nutrition.
Savannah Boda
Right. I think it's.
Jacqueline Watchmaker
You're right. I think too. And I think in neutrophil it's like 3000 or like some crazy exponential amount. Or in neutrophil. And in this study there was no, you know, patients who broke out with like acne and then just, you know, anecdotally, clinically, I do tend to be a little bit more acne prone. And I have taken it for a long time. I've had no issues. And my patients who have been on it, I mean, they haven't been on it for too long yet, but I haven't had any complaints to date of it. So I think skin better told me, you know, the reason they put it in is because, you know, the esthetician community is very smart and you know, we know that, you know, a high, high amount of biotin has the potential to, you know, maybe cause some breakouts. I do think the general population doesn't really know.
Savannah Boda
They hear biotin and freak out.
Jacqueline Watchmaker
Yeah, I don't think the general. Yeah. And so I think skin better put just like a whiff in it just to kind of identify it as a skin. Yeah, almond. But I really don't think it should be a concern at all. Like 2 versus 3,000. Like it's, there's no comparison.
Savannah Boda
No, it's like a Little tiny drop. And then also too, what we talked about in our live together is like whatever negative effect it could have, like the other ingredients and the supplement would counteract that. And that's kind of how I feel about some poor clogging ingredients. People are like, oh well this has like a poor clogger. I'm like, okay, but the exfoliation and antibacterial properties of these other ingredients in the formula is gonna counteract whatever small percentage of this poor clogger is. Or you know, I think everything's like double in the dosing and nothing in life is white or black. And so yeah, I think even if it did have a higher amount of biotin, I think a lot of the anti inflammatory components of Biorewind would counteract that. But again, it's so minute, guys, like it is like not even worth even mentioning or putting on the bottle. That's how small it is.
Jacqueline Watchmaker
I, I agree. And like you said like rosemary acid is like, it's like anti, inflammatory, antibacterial. I think there's even some like antiviral properties. So like all of like the inflammation that is at the core of acne, the rosemary acid and the kind of the positive beneficial effects of this supplement I think are going to way, way, way outweigh the tiny potential that this whiff of biotin is going to have.
Savannah Boda
I love that.
Jacqueline Watchmaker
Yeah.
Savannah Boda
Okay, so I think we're about at time, but tell us any last closing thoughts or anything you want to leave our listeners with. Where can they find you, your favorite color?
Jacqueline Watchmaker
My favorite color is probably turquoise.
Savannah Boda
Okay. Okay. That's so Arizona of you.
Jacqueline Watchmaker
I know. I love turquoise and I. Yeah, I practice in Scottsdale, Arizona. You can find me here. I'm the only Jacqueline watchmaker around, so you can google me. My Instagram I think is at Dr. Jacqueline Watchmaker.
Savannah Boda
If you go to my following, you'll find her too.
Tyler Jacoby
If you live in Arizona, anywhere in the whole state.
Savannah Boda
Yeah, you gotta go see her. Yeah, she's amazing. I really feel like even though I love that you're a dermatologist, I feel like in another life you should have been a watchmaker because that would have been so iconic.
Jacqueline Watchmaker
I know.
Tyler Jacoby
Is that your married name?
Jacqueline Watchmaker
No, I didn't change it. So it's my. Yeah, all my or one of my sisters changed it, but most of us kept it. It's just, it's too good to switch.
Savannah Boda
No, I love it. It's so fun. It's a good last name and it's like a memorable one too.
Jacqueline Watchmaker
Thank You.
Savannah Boda
Well, we love you. She has to go get back to her clinic today. She has a lot of more important things to do than chit chat with us rascals. But we love you and hopefully we get to see you in person and soon. I'm sure we'll have something come up or we'll just have to fly down and have a girls weekend with you.
Jacqueline Watchmaker
Yeah, come have a spa weekend.
Savannah Boda
Yes, we definitely will. We love you. Thank you so much for doing this. You are phenomenal. You guys are literally just got blessed by the best. She is so smart, like, it blows my mind.
Jacqueline Watchmaker
Thanks, guys.
Savannah Boda
We love you. Bye. Have a good day.
Jacqueline Watchmaker
Bye.
Savannah Boda
Salt of the earth.
Tyler Jacoby
The second we met her, I was.
Savannah Boda
Like, they're like, oh, like one of the doctors that conducts clinical trials is coming to the center. I'm like, oh, they're probably gonna be like, boring. Oh, no, not boring.
Tyler Jacoby
Because there was like 20 people at this thing we were invited to and we were stuck to her at the end.
Savannah Boda
Like, we were like, that was our first. But she's just so intelligent and just so beautiful. So smart and just kind. I think, you know, anytime I hear doctors, I'm like, get a little nervous because a lot of them can have really big egos. And just especially for me, like little fucking Estee that went to school for seven months. And then Tyler, who is just a placebo esthetician, basically.
Tyler Jacoby
Hey, I'm your esthetician, so watch yourself. Watch yourself.
Savannah Boda
That is true. Yeah. They could be like, why would I want to, like, waste my time with you? Like, you're so beneath me. But she's just not like that at all. Like, she's just an angel. I love her. I love her more than I love by rewind. I stand by that. But I do love Briar Rewind a lot. And you guys can get it on our skin butter link if you want to try it.
Tyler Jacoby
Absolutely.
Savannah Boda
Link in bio reversing that glycation.
Tyler Jacoby
Or you can always request a quote on our website too if you want some other goodies.
Savannah Boda
Explain that, Tyler, because that confuses a lot of people.
Tyler Jacoby
I don't. I feel like it's pretty self explanatory. But if you go on any of our Skin Better products, it will have a. You'll have two options. It'll say request a quote, which is means that we will fulfill it. We'll receive your requests and you can select the sizing. This is the only way also that you can get Skin Better travel sizes. Because Skin Better doesn't sell their travel sizes directly on their website. So if you're looking to, you know, get a 15mL of L2 advanced, then come to our website to do that because again, you can't purchase it on Skin Better's website. So you'll just literally hit request a quote or request order, click on it and then you'll see all the different sizes. Normally it's like 1.7 ounces, 1 ounce. And then you have the smallers, you add the quantity and then you it'll say, do you want to add other items to your quote or do you want to submit your quote? And then you fill out your information. It'll send us your contact information similar to like when you're filling out to check out anywhere. So first name, first name, last name, email, phone number, you, name won't charge you. Then it'll send it to us and then we will email you back an invoice. Or there's the second link below that says shop this product on Skin Better and that's through Savannah's portal on Skin Better's website. They fulfill those orders. That's great. If you're not looking for travel sizes, if you're looking to take advantage of the promo, Skin Better basically always has a promo going. So if you spend a certain amount of money, you can get a free 15ml Alto advance and a free tone smart lotion, whatever promo they're running that month. We, we don't get those promos in our clinic. So if you want to take advantage of that, shop their Skin Better's website. And if you want a pretty pink package with an affirmation card and some SBA stickers and some travel sizes, then.
Savannah Boda
Shop through SBA Slay.
Tyler Jacoby
Okay. We love you.
Savannah Boda
Love you guys. Have a blessed Monday. We love.
Release Date: April 28, 2025
Host: Savanna Boda
Guest: Dr. Jacqueline Watchmaker, Board-Certified Dermatologist
In this episode of The blondEST, Savanna Boda welcomes her co-host, Tyler Jacoby, and introduces their special guest, Dr. Jacqueline Watchmaker. Savanna gushes about Jacqueline, highlighting her as a mentor, friend, and a leading expert in dermatology.
Savanna Boda [00:10]: "We have a very special friend, a mentor, a friend, a sister, colleague, the queen of everything, Jacqueline Watchmaker."
a. Understanding Glycation
Dr. Watchmaker provides an in-depth explanation of glycation, the process where sugars react with proteins or lipids without enzymes, leading to the formation of harmful compounds known as Advanced Glycation End Products (AGEs).
Dr. Jacqueline Watchmaker [04:20]: "BioRewind is basically an anti-glycation supplement... glycation is a non-enzymatic reaction that occurs in the body when sugars bind with proteins or lipids, forming AGEs."
b. Clinical Studies and Efficacy
Jacqueline discusses the rigorous clinical trials conducted for BioRewind, emphasizing its role in preventing and reversing glycation. The supplement utilizes proprietary extracts of rosemary to achieve its effects. She highlights the study's robust design, including double-blind, randomized trials with over 100 participants, and blinded lab analyses that confirmed significant reductions in oxidative stress and AGEs.
Dr. Watchmaker [11:56]: "This study was a double-blind, randomized clinical trial with over 100 participants... Both the oxidative stress markers and the AGE markers were improved in the supplement group."
c. Benefits Beyond Skin Health
While BioRewind is primarily marketed for skin health, Dr. Watchmaker speculates on its potential benefits for overall organ health by reducing systemic glycation. She shares personal anecdotes and observations from colleagues indicating improvements in various health markers.
Savanna Boda [24:19]: "Do you feel like it could help with the organs and all over glycation more than just the skin?"
Dr. Watchmaker [24:35]: "I do think it probably is helping more than just our skin."
The conversation shifts to Maestro, another standout product from Skin Butter. Dr. Watchmaker praises its effectiveness, especially for conditions like rosacea, and shares her personal commitment to the product.
Dr. Watchmaker [01:51]: "I love Maestro... it's probably the most innovative and best results that I see and just really big changes in people's skin."
She recounts experiences from clinical trials and personal use, noting a high rate of continued use post-study due to visible results.
Dr. Watchmaker [02:25]: "Patients see the results and they want to continue it, which speaks highly of that product."
Savanna and Tyler commend Skin Butter’s dedication to clinical research and ethical product development. They contrast Skin Butter’s approach with other companies that may cut corners or prioritize profit over efficacy.
Savanna Boda [10:21]: "Skin Butter does that with so many things... They've really invested in making products that no one's done before."
Dr. Watchmaker elaborates on the painstaking process behind Skin Butter’s formulations, including extensive testing and multiple iterations to achieve perfection.
Dr. Watchmaker [19:24]: "They kept going back to the drawing board until it was perfect... It was more than a year in the making."
The hosts discuss the transition from Oxygen Wash to Refining Foam Cleanser, highlighting preferences and adjustments in product use.
Savanna Boda [20:18]: "I think Refining Foam is better... It took me a bit to adjust because I was so attached to Oxygen Wash."
Tyler Jacoby [32:02]: "Personally, I like Refining Foam better. Oxygen Wash was too strong for me."
Biotin's inclusion in BioRewind raised questions about potential acne outbreaks. Dr. Watchmaker clarifies that the biotin amount is minimal and unlikely to cause breakouts, reassuring listeners about its safety.
Savanna Boda [29:29]: "Why did they add biotin? Is it going to cause acne?"
Dr. Watchmaker [29:39]: "It's like the tiniest little sprinkle... In this study, there were no patients who broke out with acne."
She emphasizes that the anti-inflammatory properties of other ingredients in BioRewind counterbalance any negligible risks.
Dr. Watchmaker [31:39]: "Rosemary acid is anti-inflammatory and antibacterial, so it outweighs the tiny potential effect of biotin."
In the closing segment, Dr. Watchmaker shares her favorite color and provides information on how listeners can connect with her. She encourages listeners in Arizona to visit her clinic and highlights her Instagram presence.
Dr. Watchmaker [32:15]: "My favorite color is probably turquoise... You can find me on Instagram @DrJacquelineWatchmaker."
Savanna and Tyler wrap up the episode by expressing their admiration for Jacqueline and promoting Skin Butter products, guiding listeners on how to purchase through their website or request quotes.
Tyler Jacoby [34:50]: "You can always request a quote on our website if you want some other goodies."
BioRewind Supplement: An anti-glycation supplement designed to prevent and reverse glycation, improving skin health and potentially benefiting overall organ health. Backed by robust clinical trials.
Maestro Skincare: An innovative product highly effective for treating rosacea and other skin conditions, with strong clinical support and user satisfaction.
Skin Butter’s Dedication: A company committed to rigorous research, ethical practices, and continuous innovation in skincare, distinguishing itself from competitors.
Product Formulation: Emphasis on perfection through extensive testing and multiple iterations to ensure product efficacy and safety.
Biotin in BioRewind: Included in minimal amounts to prevent concerns about acne, supported by the supplement’s anti-inflammatory properties.
Accessibility: Listeners can connect with Dr. Watchmaker via Instagram and purchase Skin Butter products through Savanna and Tyler’s website.
Dr. Jacqueline Watchmaker [04:20]: "BioRewind is basically an anti-glycation supplement... glycation is a non-enzymatic reaction that occurs in the body when sugars bind with proteins or lipids, forming AGEs."
Savanna Boda [10:21]: "Skin Butter does that with so many things... They've really invested in making products that no one's done before."
Dr. Watchmaker [11:56]: "This study was a double-blind, randomized clinical trial with over 100 participants... Both the oxidative stress markers and the AGE markers were improved in the supplement group."
Dr. Watchmaker [31:39]: "Rosemary acid is anti-inflammatory and antibacterial, so it outweighs the tiny potential effect of biotin."
This episode of The blondEST provides valuable insights into cutting-edge skincare solutions, emphasizing the importance of scientific research and ethical practices in product development. Dr. Jacqueline Watchmaker’s expertise underscores the efficacy of Skin Butter’s offerings, making it a must-listen for anyone invested in advanced skincare.