Episode #111 Featuring Dr. Elizabeth Yurth and Dr. Robin Rose! The MOST COMPREHENSIVE Functional Medicine Interview! SGLT2 inhibitors, GLP-1's, Plasmalogens, Neuroplasticity, Covid dangers and more!

Summary

Podcast Summary: The Dylan Gemelli Podcast

Episode #111: The MOST COMPREHENSIVE Functional Medicine Interview! Featuring Dr. Elizabeth Yurth and Dr. Robin Rose
Date: April 14, 2026
Guests: Dr. Elizabeth Yurth (Boulder Longevity), Dr. Robin Rose (Terrain Health)

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Episode Overview

In this episode, host Dylan Gemelli welcomes two leading voices in functional and longevity medicine: Dr. Elizabeth Yurth and Dr. Robin Rose. This wide-ranging discussion dives deep into cutting-edge strategies for optimizing health, including SGLT2 inhibitors, GLP-1 agonists, neuroprotection, brain health, COVID’s long-term effects, the changing food landscape, metabolic flexibility, and practical supplementation truths. The conversation is energetic, candid, and rich with clinical experience, making it a genuinely comprehensive exploration for anyone serious about healthspan and quality of life.

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Key Discussion Points and Insights

1. SGLT2 Inhibitors: More than a Diabetes Drug

[05:33 – 17:38]

• What are SGLT2 inhibitors?

  • Drugs like Jardiance (empagliflozin), originally for diabetes, block glucose reabsorption in kidneys, leading to excretion of glucose via urine.
  • "It's literally one of the most multifaceted drugs I've ever come across that does so much." – Dylan (08:15)
  • Benefits extend beyond blood sugar to heart and kidney health, reducing cardiovascular inflammation, modulating the gut microbiome, and lowering uric acid.
  • Used in long COVID patients for microclotting and overall metabolic dysregulation.

• Clinical Effects & Side Benefits

  • Neuroinflammation reduction, weight management (though not a true weight-loss drug), improvements in heart failure and kidney decline.
  • Caution: Can cause electrolyte depletion and dehydration (potassium loss), so supplementation and hydration are key.

• Barriers to Adoption

  • Not as trendy as GLP-1s for weight loss, so less patient-driven demand.
  • Expensive if not diabetic, but can be compounded affordably.

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2. GLP-1 Agonists: Myths, Benefits, and Best Use

[17:39 – 34:04]

• Role & Misconceptions

  • Not just about weight loss; profound effects on longevity, metabolic health, neuroprotection, and inflammation.
  • Problematic in media due to overprescribing, mega-dosing, and lack of holistic coaching.
  • "They're the most wonderful, wonderful...I think they are incredible. And it’s a shame how they have been misinformed about." – Dr. Rose (19:22)

• Muscle Loss Myth

  • No mechanism by which GLP-1s cause muscle loss; muscle loss stems from insufficient nutrition and hydration while on the drug.

• Responsible Use

  • Ideal: Titrate down to low or microdoses after initial therapeutic phase; never stop in those with genetic causes of obesity (FTO mutation).
  • Emphasize high protein intake, resistance training, lifestyle changes.

• Flashpoint Studies

  • British Medical Journal meta-analysis: ~50% of people regain weight if GLP-1s are stopped—often due to improper protocols or genetic underpinnings.

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3. Neuroprotection, Brain Health & Plasmalogens

[35:07 – 47:39]

• Neglected in Longevity Medicine

  • Brain fog, cognitive decline, and neuroinflammation often overlooked compared to body composition and hormones.

• Plasmalogens

  • Specialized phospholipids created in the peroxisomes, essential for protecting neurons—most people become deficient with age or post-illness (e.g., COVID).
  • "Almost everybody as we age gets plasmalogen deficiency…Almost all of us need plasmalogen replacement." – Dr. Yurth (43:03)
  • Replacement (precursor via Prodrome Sciences) prevents and may reverse neurodegenerative changes; evidence in cases of early dementia and even ALS.

• COVID, Brain, and Youth

  • Even mild or asymptomatic infections can cause permanent brain changes in young people.
  • Epidemic rise in early-onset neurodegenerative illnesses post-pandemic.

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4. COVID’s Systemic Effects: Testosterone, Fertility, and Inflammation

[51:03 – 55:14]

• Pandemic Fallout
  • "I’ve never seen so many men, so many young men, with testosterone deficiency." – Dr. Rose (54:22)
  • Spike protein has high affinity for reproductive organs; rises in both male and female infertility, menstrual disturbance post-infection.
  • Marked increases in oxidative stress biomarkers (e.g., myeloperoxidase/MPO) and reduced hormonal resilience observed clinically.

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5. Food, Fats, and Metabolic Flexibility

[57:10 – 75:45]

• Macronutrient Prioritization

  • Move away from the old food pyramid (high carb) toward prioritizing protein and healthy fats, with carbs on the lower end unless training demands more.
  • "The healthiest people can switch between a glucose-fed state and a ketone fat-fed state. If you never do that, you’ll see mitochondrial function decline." – Dr. Yurth (59:13)

• Types of Carbs and Fats

  • Favor complex, whole-food carbs (vegetables, lower-glycemic fruits, sweet potatoes, white rice).
  • Use timing and food sequence (protein/fat before carbs) to blunt glucose spikes.
  • Avoid seed oils, manage omega-3 to omega-6 ratios, and tailor saturated fat intake to genetics (APOE status).

• Breakfast Guidance

  • Fasting for 12–16 hours is beneficial, but not in the severely ill, elderly, or very lean.
  • Eggs (whole) are "the most valuable nutrient source," and fears about cholesterol from eggs are unfounded (86:16).

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6. Supplement Wisdom: What Works, What Doesn’t

[87:45 – 102:07]

• Top Underappreciated Supplements

  • Ketones: for inflammation, brain energy, muscle energy.
  • Alpha-Ketoglutarate & Urolithin A: for mitochondrial health; often underdosed in commercial products.
  • Ozonated Glycerin (OG): for immune resilience (ingested, nebulized, topical), potent antimicrobial without gut microbiome disruption. "It kills the bad [bacteria], not the good..." – Dr. Rose (96:52)
  • Antibiotiques: innovative postbiotic approach—autoclaved healthy donor stool providing metabolites to support gut repair, especially in leaky gut and autoimmunity.

• Supplements to Skip

  • Branched Chain Amino Acids (BCAAs): little to no benefit over a whole protein source.
    • "There's really zero evidence that you're not better off just eating protein than taking your silly BCAAs." – Dr. Yurth (99:04)
  • Multivitamins: Most are underdosed and poorly absorbed, leading to "expensive pee."
    • "All you’re doing is just creating expensive pee." – Dr. Rose (100:36)

• Other Supplement Insights

  • Many products seriously underdose the active ingredients due to cost or marketing.
  • Always check dosing against clinical studies, not just label claims.

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Notable Quotes and Memorable Moments

• On Disagreement and Growth:
  "Robin and I don't agree on everything, so that'll be perfect." – Dr. Yurth (03:22)
• On Brain Health Neglect:
  "The brain gets sadly really neglected in our world." – Dr. Yurth (48:25)
• On Changing Your Mind:
  "We always have to be willing to change our mind. That’s huge." – Dr. Yurth (106:52)
• On Social Pressures and Testosterone:
  "We really, unfortunately created a society where we want low testosterone. It's better, more passive....It terrifies me for my boys." – Dr. Yurth (53:11-53:52)
• On Diet Evolution:
  "If you’re living in that fear or whatever—I’m the leanest I’ve been. I feel phenomenal. And I’m not miserable or hungry all day, right?” – Dylan (70:41)
• On Storytelling and Young People:
  "Stories are great. Real life goes a long way to change people." – Dr. Yurth (78:57)

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Practical Tips & Clinical Pearls

• SGLT2 and GLP-1s:

  • Use as multipurpose metabolic/anti-inflammatory drugs, not just for diabetes or weight.
  • Ensure proper dosing, nutrition, hydration, and avoid rapid titration or discontinuation.

• Protein First, Carb Last:
  Eat protein and fat first at meals to moderate postprandial glucose (82:52).

• Targeted Labs/Markers:

  • Look beyond standard cholesterol: check ApoB, Lp(a), myeloperoxidase (MPO), particle sizes.
  • Early and advanced markers for cardiovascular and neurodegenerative risk.

• Personalization Always Wins:

  • Use genetic markers (e.g., APOE) to tailor fat intake.
  • Use CGMs to personalize carb tolerance.

• Plasmalogen Replacement:
  Consider for cognitive complaints or after viral illness; ask about Prodrome Sciences product.

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Timestamps for Important Segments

• 05:33 – 17:38: SGLT2 inhibitors—mechanisms, indications, and future
• 17:39 – 34:04: GLP-1 agonists—real benefits, misuse, and weight regain
• 35:07 – 47:39: Neuroprotection and the role of plasmalogens
• 54:14 – 55:14: Rise in testosterone deficiency and fertility challenges post-COVID
• 57:10 – 75:45: Dietary priorities, fats, carbs, metabolic flexibility
• 87:45 – 102:07: Supplementation—game changers and common mistakes

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Closing: Projects and Ways to Follow

Dr. Elizabeth Yurth and Dr. Robin Rose:

• Both are active on the functional medicine conference circuit and are launching their own "Medical Mavericks" mini-podcast soon.
• For current projects, lectures, and resources, check their respective clinic websites:
  • Boulder Longevity (Yurth)
  • Terrain Health (Rose)

Dylan Gemelli:

• Stay tuned for future episodes expanding on these topics.
• Full details and links to follow the guests are in the podcast description.

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Summary prepared by AI; for all specific health interventions, always consult a knowledgeable provider familiar with your case.

Transcript

[A]

Today's episode is sponsored by Apollo Neuro. Apollo Neuro is the leading doctor Recommended wearable technology. Apollo's award winning smart vibes AI works effortlessly behind the scenes, automatically integrating into your life to deliver gentle personalized vibrations that activate your vagus nerve, helping you fall asleep faster, stay asleep longer and wake up balanced, focused and ready each day. Not only that, but the Apollo Neuro is the first and only wearable that improves your hrv. Apollo is effortless. Simply wear it throughout the day and night and let it do the work for you. It's safe for anyone and everyone with no side effects and is the only wearable that can be worn anywhere on your body. Optimal health requires both the mind and body to be in and Apollo is the key to establishing that connection. Check the description below to save $90 with my special discount. Take control over your health today with Apollo Neuro. All right everybody, welcome back to the Dylan Gemelli podcast. So I have a special edition special treat for everybody today. I have not done this before. Super blessed to be able to do this now. One of my guests is the very first person that's been on here three times. My other guest is making her second appearance. She's had one of my top downloaded episodes. These two women are on another level of brilliant. Two of my favorite people to talk to, to laugh with, to learn from and who I hold in extremely high regard. One Founder of Terrain Health Covid expert Such a kind hearted woman has a new book coming out this year. Hopefully I cannot wait for that. I'm going to encourage everybody to take a look at my second guest. I have spoken about at length about the impact she's had on me personally, professionally and every other which way. Founder of Boulder Longevity and well known all over the place for multitudes of expertise levels. There's not enough that I could say about you both other than I love you both and thank you for coming to see me. It is an honor, blessing and privilege to introduce to you Dr. Elizabeth Yurth and Dr. Robin Rose.

[B]

Dylan, you know we feel the same about you, so we're honored to be here and thank you for inviting us. Absolutely.

[C]

That was a really lovely introduction. Thank you. And the feeling is very mutual.

[A]

Thank you so much. Before I get into everything, like I said, there's not enough that I can say both of these two, the impact that they've had on me and so many people out there, there's not enough that I could say other than please, please go educate yourself with both of them. I'll get into how to follow them and everything towards the end. But the wide variety of knowledge base that you guys both have and the hearts in which you deliver this, the motives and everything in between, it has literally changed my life in multitudes of ways. So thanks for coming to see me. And we're going to get into a lot of stuff today.

[C]

Bring it.

[B]

All right. Robin and I don't agree on everything, so that'll be perfect.

[A]

That's. Yeah, that's good.

[B]

A lot, but not everything.

[A]

No human should ever agree on everything,

[C]

but a lot we do.

[B]

Yeah, a lot we do.

[A]

Anybody, this is. They agree with everybody and everything is full of shit. But it is good because that's what

[C]

provokes thought and like, why you go, right, and we're like, you know what? You're right, you're right. And you know, I always say that's

[B]

one of the problems, right, is that, you know, you never put dissenting opinions together in like medical conferences and things like that. And we always say, boy, we'd love to hear these two people who have completely opposite opinions talk against each other. It never happens. No, unfortunately we have mostly the same opinions, but.

[A]

But that's it.

[C]

Betsy's been like an unbelievable mentor to me in so many ways too, which I'm blessed. I'm blessed to have her in my life and to call her one of my, like, best friends and closest friends.

[A]

I love that.

[C]

I just adore her. And she's amazing. Well, she's like an angel helper in my life.

[A]

I couldn't agree more. I. I totally agree. Here's one of the things that I like that I want to do with you both is because you may agree on certain things, but you also probably both have more things to add to each other's thoughts and opinions too. And then if you do have a total, a different type of opinion, it'll be good to compare and contrast. We talked about this a lot, Elizabeth and I did, in terms of the SGLT2 inhibitors. And there's, you know, how this goes in our space especially. Most people have their own, like Jay Campbell's crazy thoughts that he'll say sometimes that I know irk you, even though he's brilliant, but he says some off the wall stuff and he. I love you, Jay. If you're listening, you know that. But I also know how you are because I've seen your reactions. But that seems to be one of the things we all agree upon is how good these are, what they do, and what the future is holding for them. I know I have to Take Jardians for example, for a specific purpose. But some people just take it just because of the health benefits.

[C]

Longevity.

[A]

Yeah. So what I would like to do is first explain what exactly it is, how it works, its method of function, and then the different reasons why one would take it, whether it's health related or whether it's just because these are

[B]

what are called sodium glucose transport CO transport inhibitors. So what they are doing is in the renal tubules, we have these sglt, these sodium glucose CO transporters that actually reabsorb glucose. So basically you eat something that has glucose, your body's gonna reabsorb that into your system to act as a fuel. If you block those CO transporters, instead of that glucose being reabsorbed back into your system, you just pee it out. So basically, inherently, we are actually just lowering the glucose impact that people have when they eat food. Right. And there's huge benefits to that. When we look at most of the things, we're looking at longevity, starting with the GLPs, most things that work on metabolic control, be it intermittent fasting. Right. Or calorie restriction, the biggest pieces that we've seen really have an effect on longevity are things that really make metabolic control pristine. And this is one sort of almost cheater's way in my mind of doing that. Right.

[C]

Yeah. So I, you know, I've learned a lot from listening to Betsy and also our other colleague, Avid. That's Hussein. Yeah, that's after Usain. So I started really using them. I was using them. I remember the first time I heard Dr. Hussain talk about it at the PwC, like to like year and a half ago and I was already dabbling in it. And then I really started using them a lot after I heard all the benefits, because I was using them actually in a lot of my long COVID patients that had significant micro clotting. And I found that when I added the SGL2 inhibitors, they worked really in a very good way in helping sort of like reduce that burden because of all the mechanisms that we can get into or not get into. But anyway, they worked really great for that. And especially also because a lot of them had a lot of, a lot of insulin, glucose dysregulation. So I was having really. And then like my world was blown up when I was like, oh my God. And it impacts cardiovascular inflammation, neuroinflammation. It's a gut microbiome modulator. It's a me, it's a uric isemic. So a lot of people and we can get into that being that U shaped curve with the uric acid and having too much, too little. And so I found like people that had like a lot of like metabolic, you know, disorders and also that had high, high uric acid. It was a really nice thing to sort of kill two birds with one stone. So it really has an amazing place for so many things. But again in the longevity space it's great because of all of these things. It's like a pleiotropic drug that like impacts all these different pathways and you can have like massive impact on health.

[A]

To me it's literally one of the most multifaceted drugs that I've ever really come across that does so much such a variety of things right for me as you know, and some most do. I had a low ejection fraction and that's why I got put on it. And so I started taking it in June and I was retested in November and I had a 44 on the left ejection fraction and it was up to 50 with just jardiance D ribose powder and Hydros ubiquinol in I don't know, four months right around there. So I have to retest again in February hoping It's closer to 55 where it's supposed to be. So what conditions would one use it for? I mean I'm using it for, I hate to say heart failure but I guess pre heart failure or whatever to improve that. But what is it? What's its intended purpose? Jardiance and then what would, what else could you use it for?

[B]

Well it got to start as a, just like the GLP ones, it gotta start as a drug for diabetes, right? Because absorbing less glucose, less impact on insulin. So basically we were had a great drug for helping treat diabetics. When we start to look at its mechanisms, basically by increasing this, you know, metabolic control, you can start to see all of its other benefits. Because if I, you know, you'll get that cardiac function. If the heart really likes to run on fats and ketones and things like that. So if I block glucose then the heart gets its best fuel. Right now almost all of our systems, why I love ketones, right. Or why fasting's so good for us, is that we, if we stop the mitochondria from having to work so hard utilizing glucose, we block reactive oxygen species and we use now a better source of fuel, right? So basically by you know, blocking the glucose now we're going to turn to other sources of fuel. When you do that, you're going to improve immune function, which is why it's so helpful in the long COVID patients. Right. We've improved their immune function. We're going to improve cardiac function because the heart works better on that. And we're going to improve neural function because we all know, as we know the dementias and cognitive declines are related to glucose dysregulation in the brain. So we've established now a drug that is working on all these factors. And when you reduce the risk of disease from all of these different things, whether it be immune or brain or cardiovascular, you've reduced the risk of death from any source.

[A]

What are some other SGLT2 drugs, aside from Jardians, that one would be aware of or possibly use?

[C]

It's not. Yeah. So I usually use empiclophalosin, but the other.

[B]

So canagliflozin is. Right. You know, and so, so there's, there's what I call SGLT1 inhibitors and SGLT into inhibitors. We don't really want to get into that too much. But the SGLTs are probably the most powerful piece. The SGLT ones may have their place in certain roles. Right. So I think that when we look at from our perspective of longevity, we're going to error to the SGLT inhibitors primarily, which is primarily jardians or panagliflozin as opposed to canagliflozin, which has a little bit of SGLT1. And they're maybe that.

[C]

Which is the one that has like more. That's more cardiac specific.

[B]

Has a little bit more.

[C]

Right.

[B]

Cardiac specificity. Yeah.

[C]

Which might be better for you, but

[A]

just whatever's gonna help.

[B]

I think the, the, the downside is you also see a little bit more side effects from those drugs and other issues. And that's why I think we've started turned in our longevity world to jardiansis. Incredible. For kidney function.

[C]

Yeah. Oh, yeah.

[B]

We do not have.

[C]

Yes.

[B]

And we don't have. If you so true, kidney function declines in almost all of us as we age. Yeah.

[A]

Right.

[B]

And we don't really have any way of treating that. When I see somebody whose glomerular filtration rate is dropping, what do we have to offer that patient?

[A]

It's a good question.

[C]

And post Covid, it seemed there's so much kidney injury, so much granule acid. Yeah. And so getting them on the empicliflozin or the jardiance is like really, really important.

[A]

I'll tell you why I love it because it, I mean, I'm in the bathroom Peeing a lot. But I told Queenie I, you know, I, I can eat way more because you're peeing out like 500 calories.

[C]

Right? Right.

[B]

So they're not really considered weight loss drugs. And yet they do honestly, you know, help people with weight loss. I wasn't looking for that ones, but they definitely help with weight loss.

[A]

Oh yeah. Well, I, I was always about 185 and once I started taking it, yeah, I eat the same amount I always did and work out the same and it's, I'm on that 175 range and it's just, I haven't really changed anything. I eat a little bit more. But you know what? A couple things I've noticed is it, it's triggered heart palpitations for me because of low potassium. Because I sweat so much. I was already running on low potassium and I'm peeing out electrolytes constantly. And what I found, because I couldn't figure out what was happening and I, I, I, every time I got potassium tested low, low, low, and I started, they put me on a supplement and I started slamming more and slamming more and then it stops. So it has to be what it is. And then the entrusto was added and I already have low blood pressure so I got rid of it. Because you have to be careful with those things. Yeah. Lowering the blood pressure too much.

[C]

The other cool thing about the SG2s T L2 inhibitors are that they're gut microbiome modulators also, which is really neat. Right. So like you're, which is what we're always worried about is like the health of the gut microbiome and you know, maintaining, you know, or restoring health and balance to that microbiome. So I, I love that property of it as well. I think that's like.

[B]

Can you explain a little bit more about, you mentioned it in the microclotting world why it's so helpful there.

[C]

Yeah, I try to do like a little bit of a deep dive into why it helps with the micro clotting. It, I think it, I think it, from what I remember because I looked this up like a really long time ago, but I think it does something with, when she was talking about immune function and it has something to do with the endothelial. Endothelial self. Right, yeah. And the endothelial cells. Yeah. Because when you have that chronic low grade endothelial itis, that's obviously activating platelets and then that's also activating the clot, the clotting cascade. So when you get to that level, right. Like when you're get, when you're effect impacting the endothelial cells there, then you can, you know, get like it's like root cause sort of and you're stopping that sort of like propagation of those or the activation of those, you know, pathways.

[B]

Right.

[A]

See I wasn't that whole.

[B]

Right, yeah, the whole piece. Our immune cells, people don't think about this, but our immune cells are one of the most energy dependent cells in our body.

[A]

Right.

[B]

And we don't really think about that. When we're thinking about people who are, you know, poor mitochondrial function, low ATP states, we don't. We think about muscle, we think about heart, we think about brain, we kind of don't think about that. Our immune systems are need more energy. It's why when you look at people with long Covid or fighting viruses in general, all of their energy is going to do their immune cells to help keep this virus at bay. And so that's why they start losing energy to other places like their brain and their heart and their muscles. So if we can make energy more available. So remember, if I'm not going through oxy phosphorylation, if I'm giving fats or ketone bodies, which is what your body's going to turn to as a fuel when it doesn't have glucose, you make much more ATP per molecule of oxygen. So basically now you've markedly improved energy function because I've swapped out this mitochondria having to work really hard to make energy. I've given them a simple source of energy and it's a better, cleaner source of energy. So that's why it's so, so huge really is we've changed our energy source.

[A]

Do you think it's going to be something that's continuously more prevalently prescribed and used in the future as we see more conditions and areas that it treats?

[B]

That's a good question. Is in the, in our world when we study pathways we're like, oh my God, who wouldn't?

[A]

So in our world, yeah, so in the good world.

[B]

But when you look at, you know, the reason the GLP is cut on and now it's like, oh, they're great for longevity too. Is the weight loss piece. Right, right. And these don't have that dramatic of an impact there. So I think they're going to be a little harder to grab the attention of these physicians. Physicians grabbed onto the GLPs because their patients were demanding it. Patients aren't going to go into banding jardians right there.

[A]

If they knew and understood.

[B]

Right. And so I don't know the doctors are, who are invested in research and looking at all these things are going to have the awareness. So I don't think we're going to see them catch on nearly as rapidly as like the GLP1 agonist.

[C]

That makes sense.

[A]

And I went and got the Jardian's card online and it cost me $0.

[C]

Oh, that's great.

[A]

Seriously.

[B]

So because it is an expensive drug if you don't have diabetes, but usually that only works like three months.

[A]

Yeah, I got a year off. Did you satska?

[C]

Yeah. But even if you compound it, it's not that we actually do. It's not very. Yeah, so do we. It's not very expensive.

[B]

So if you get a compounded. If you don't have diabetes and you get the, and you get Jardians, it can be a thousand dollars. So we can get it compounded for much less.

[C]

That's what we do.

[A]

Yeah, that's excellent. So to shift a little bit then, since you brought up GLP1s a little bit there, let's do another discussion. Should we talk briefly about this? But let's get more into it. Let's talk about. I want to do some numbers here and maybe some what you've seen with people that you have on it or things that you've observed. So when it comes down to the weight loss, use of it and when people stop, how big of an issue is it in terms of their hunger increasing drastically? Have they lost so much muscle they're gaining a lot of fat back? Like what do we see in percentage wise on stoppage and results of weight gain back and then problems with their eating patterns and everything from from then on.

[C]

Okay. So I am a big proponent of GLP1s and I don't really stop my patients.

[A]

Okay.

[C]

I switch them. So if they were using it, let's say because they're diabetic and because they have to lose weight, they'll be on more of a standard dosing regimen. Right. And then once they've reached their goals and they've gotten to where they are, I then put them to a very low dose or micro or what they call micros.

[A]

Microdosing.

[B]

Yeah.

[C]

Because I believe the impact of this, of this drug class is, is so impressive for longevity. And again, you know, we'll get into what the, what the SGL2 inhibitors do. Right. It's the same thing with these like pleiotropic like drug impacts, all these different systems Neuro, cardiac, you know, pain modulation addiction, like all these things that we're going to get that we will talk about. Debbie, Betsy will go into even more depth, I'm sure.

[A]

Please.

[C]

But I honestly, like, I think they're wonderful. And the problem is, is they get such a bad rap in the mainstream media because they've been mega dosed and overused and doctors and Medispas and all these places are using them and not utilizing the right way and the patients aren't being counseled the right way. So when you're, you know, when we're using them, right, our patients know that they have to be eating at least one pound or more per gram, you know, per gram of protein per, per body weight, right. That they have to be doing resistance training and exercising and doing all the things to help like, you know, build and maintain lean muscle mass, right? They're, they're in a program with us. They're doing all the things to maximize the benefits of the GLP1s. Okay? And so when you have this famous actor, actress that goes on the GLP1 and all of a sudden you see befores and afters of them on Instagram and TikTok and all that stuff. That's because, yeah, they were being mega dosed. They weren't being counseled, right. On like how to eat, what to do. They're still going to the best steakhouse every night. They're still drinking every night. They're still, you know, living their stressful life, right? Like we're also like talking about, you know, stress management and you know, helping patients with cort cortisol dysregulation, all that stuff like plays a role and also improving the health of their gut microbiome, all that plays a role in metabolic health. These patients are not being counseled that way, right? And then what gets me, and what gets me so pissed off is that then all of a sudden they go off of it and then they're like, oh, look what happened. They gained all the weight back. It's because of the way they're being dosed and overdose and again, not going through the lifestyle modifications and the changes that need to be done, you know, and their labs aren't being, you know, monitored. Like there's so many things I can talk about, but it's a shame because they are like the most wonderful, wonderful. Like most of my patients with chronic complex diseases, pretty much every long COVID patient is on a GLP1 because of what they do for, you know, mitochondrial, you know, health as well. And Efficiency and what they do for all these other pathways, I'm sure Betsy will deep dive into. But they are incredible. And it's a shame, you know, how they've been sort of mis. We've been misinformed about it.

[A]

Oh, yeah.

[B]

So completely agree. Let's talk about how big a problem this really is because British Medical. So this just got all this play, right? Because British Medical Journal just came out with a article. It was 37 studies reviewed to really look at what is how many people truly did regain the weight. And it was high. 70% of people regained weight. Not all of those back to their baseline, but about 50% or a little over 50% gained back to their baseline, back to where they started. Right. So we know it is an issue.

[A]

Right.

[B]

And as Robin said, it's because people are using these in the wrong way. But I want to kind of, I want to make a point here, please, that when you look at the number of people who gain the weight back, so about, you know, almost 50% didn't gain the weight back. Look at the number of people who have genetic issues with like the FTO gene. So what is the FTO gene? And it's prominent, especially if you're European, Caucasian, it's a prominent gene. So about 40% of people have a mutation in this gene, which makes their. They have normal GLP receptors, but their body does not respond normally with glp. So. So if you look at the. I've got a drug now that treats a genetic disorder. To me, stopping a drug in these people, it would be like, okay, if all of a sudden I came up with a drug that cures cystic fibrosis. And I just went, you know what? You just need to breathe better. High cystic fibrosis patient. Right. You know, you're just not breathing well enough. You know, I'm not going to give you this drug because you just, you know, you just need to breathe harder.

[A]

Right.

[B]

That's like telling my FTO patient who is a double mutation, you as a homozygous mutation, fto, you just need to try harder not to eat because they are never going to be satiated. They are not. Right now I have a drug that does exactly what their problem lies. It makes them satiated. Should I stop giving that drug ever? No. I have a drug that treats why they're fat. I should never stop it. Right. So to say these people are all just going back and eating.

[C]

Yeah.

[B]

Because lots of people don't have the, the messages to their brain to stop eating.

[A]

Right.

[B]

And now I'm giving them something that actually allows that. So I, like Robin, rarely take my patients off of the gop.

[C]

You just bring them down.

[A]

Yeah.

[B]

Like, I bring them down to a nose and they make great dose. Right.

[A]

Long term.

[B]

But we are in the minority. Right. Most doctors are going to say, hey, you need to be off this drug now. And to me, again, I have a drug now that is treating a genetic disorder, a complication, you know, or. Or someone who just doesn't have the willpower.

[A]

Yeah.

[B]

You know people who have a binge eating disorder. Right. Just tell my binge eating disorder patients, oh, you know, just stop throwing up.

[C]

Right.

[B]

You can't.

[A]

Yeah.

[B]

So now I have a treatment for it. And for me, for doctors to say, I can't give this to you anymore because you. You already ran a course and you should just be eating better is ridiculous.

[C]

But because piggybacking off of that, it's the. It's the. You don't know what you don't know. Right. They don't understand, like, all these unbelievable benefits. Right. And what's so comical about the whole thing is that most conventional doctors don't have problem pushing drugs and prescribing for their patients, but yet this one.

[B]

Yeah.

[C]

One amazing intervention. They're like, nope, you got to get off of it now. Because they don't understand really, why they were giving it to the person to begin with. And if it was just for the weight loss part, well, that's sort of sad, right?

[A]

Yeah.

[C]

And so they don't have a full understanding.

[B]

So we're doing a lot of injustice to patients in this world. And, you know, and so those of you who, who have, you know, who have stopped these drugs and gained the weight back, it's, you know, maybe you just are, you know, are somebody who doesn't give a. And just eats all the time, but most of those people are not.

[A]

Right.

[B]

My patients, who I've worked with now for 20 years, and, you know, I could tell you they. They ate perfectly. I can tell you I diet lots on them. They were exercising. They're doing everything right. And not losing weight. These drugs were godsend.

[C]

Yeah. I just hate, though, like, how they showcase more of, like, the famous people or they spot like that, because that's just like a bad example of, like, what not to do. Right, Right. And those patients aren't, again, being followed likely in the way that they should be. So that's what I hate about it too. Right. Because of what Betsy says. Like. Yeah. Like, if you're going to stop it. You will gain it back probably in a lot of these patients. But again, I don't think those patients were doing the right thing to begin with anyway, or weren't being followed and monitored and probably treated. Right. Right. And then it, it gets sensationalized and then it gets a bad rap.

[A]

That's it.

[B]

I do want to, you know, we really have to get rid of the myth that GLPs cause muscle loss.

[C]

Yeah.

[B]

Absolutely not. There's zero mechanism that GLP1 agonists cause muscle loss.

[A]

Right.

[B]

Not eating, not drinking causes muscle loss. Right. You need to drink water. GLP1, GLP1. So the dopul is keeping. You get muscle loss. It is, it is very hard. I mean, any of you who have been on them is very hard to eat enough when you're on these.

[A]

Yeah.

[B]

Which is why you have to find the dose that people stop eating.

[C]

Right. Dose to symptom onset.

[B]

That's what I do when I, when I find my patient can't eat anymore, I'm like, got a bath. I have to get these calories in you. I have to have you drinking water. So I think that's, you know, raw Tide as a triple agonist helps a little bit because. Because it has glucagon agonist activity, so it preferentially loses fat over muscle. So. So you do get red. True Tide is going to be a little bit more protective. Even if you're not eating enough calories, but not completely, you will still lose muscle on Red Shoe Tight as well.

[A]

Yeah. And that's part of the problem there too is people don't understand just how hard it is without something like that.

[B]

It's so hard to eat enough protein.

[A]

Yeah. So hard to put on. Even two pounds of muscle is hard.

[B]

Really hard, right?

[A]

Yeah, it is hard. And people have this conception in their head that, oh, if I do this or that if I eat too much, I'm going to gain muscle. It is a terribly difficult thing to do.

[B]

It's hard to eat. I mean, you know, I strive to get 120 grams of protein a day. It is a struggle for me to be single.

[A]

Well, some. If you're busy like we are, sometimes

[B]

I put the crack and I get right. It's two o'. Clock. You haven't eaten anything all day right now. What are you doing?

[C]

The worst patient.

[B]

Yeah. It's not my own worst. It's very hard. And so now when you have something that's suppressing your appetite, even harder. Yes, you. And just a reminder how important hydration is to Muscle. Right. If you are under hydrated you will lose muscle always. You know and. And most of us are under hydrated. Especially if you aren't real people sensors like a cat.

[A]

I didn't realize. And that's another thing just how much I don't drink enough.

[B]

Right?

[A]

You don't drink enough water during. Not even close. Especially on like something like Jardians where you're peeing all the time on top of sweating too and.

[C]

Yeah, yeah. And because people also like. Like us who are so busy it's like I don't want to drink as much water because then yeah. I have to get out and run to the bathroom every minute and I have patience. Right. And I. I have all this work to do. I don't have time to keep running to the bathroom. Right.

[A]

I'm already in there every 20 minutes.

[B]

The that is one of the things with SGLTS is they definitely. They need urinate more. Right. You definitely urinate more. So they're losing some hydration. So you have to encourage people. They've got to be. They've got to be hydrated.

[A]

Yeah.

[B]

And I love using things like. Like plug for icel water. You know I saw water is an osmotic load of hydration. So you add this to your water and it osmotically pushes the hydration into these cells. It's like so love like you know and then that.

[C]

And then that also helps with like protein synthesis mitochondrial.

[B]

So you can get a little.

[A]

You know what I notice every I don't know, three or four weeks I have this like two day period where I weigh like three pounds more because I'm holding water because I think I'm not drinking enough and all the space.

[B]

Yeah.

[A]

It's just like doing that and then the next day I wake up for like today it was three or four pounds later because I. Yeah. Because I went to the bathroom 35 times yesterday.

[B]

Yeah. So sometimes. Yeah. If your osmotic load isn't right it all starts basing right. So yeah. Just got off a plane. You've always subcutaneous fluid that sort of just collected and you know it's not doing you any good. You know what the water in the cell.

[C]

Yeah. That's why like we use that a lot. The ice. I think it's such a good cheat. It's such a good sheet. So like it really gets called ice

[B]

like really around it's better osmotic low. So when you drink your water it goes intracellular instead of extracellular. That's where you want the water and if you guys do like in body or secret scans, it gives you like, what is the intracellular water? Was the extracellular one. We really have to get intracellular water.

[A]

You got to show me that off camera.

[C]

It's awesome. You can easily get it. Yeah.

[A]

What if I told you that one molecule helped keep your body's system cleansed, supported immune health and cellular protection all at once? I'm talking about glutathione, AKA the body's master antioxidant. It exists inside nearly every cell, helping to protect DNA, proteins and cell membranes from oxidative stress, as well as playing a major role in liver cleansing, mitochondrial energy production and immune balance. Unfortunately, pollutions, toxins. Toxins and stress can rapidly deplete glutathione levels. And as we age, glutathione production decreases as well. And many traditional glutathione supplements do not absorb well, making it extremely difficult to raise intracellular levels where glutathione actually works. And that's why I use Glutaryl, the multi patented topical glutathione developed by the amazing Dr. Nayam Patel. Instead of relying on digestion, glutaril absorbs through the skin, helping provide a convenient and consistent way to support the body's most important antioxidant system. So use my link in the description and code, Dylan, to save 15% off today. So, you know what some of this reminds me of is the way the GLP ones are given out like candy and misunderstood, mis, misdiagnosed or the, the protocols are all over the place. So it's like when longevity clinics came out and testosterone was just wild, wild west. And that's how it started. Now it's gone into this to where they're putting people on TRT with 6 and 700 testosterone numbers, people that don't need it, or telling them to run everything under the sun, or the steroid dealer tell them to do this or that and then people think more is always better. And now it's the same thing with this. And then it draws a bad rap because of course if you use a gram of testosterone, you're going to have problems.

[B]

Exactly.

[A]

You know, and then you don't see the good side of it and how it's supposed to be used. And it's terrible.

[B]

A huge problem in our world. Right. And you've seen it with peptides now.

[A]

Yeah.

[C]

Why they question everyone. Questions every.

[B]

Right. Things used inappropriately are going to have bad consequences. And it's not the thing that was the inappropriate use of the thing.

[A]

Exactly how prevalent do you think the inappropriate uses of GLP1s in your eyes? I mean, do you think it's like 50%? 60? I know, it's. There's no way to know, but. And just from what you guys observe,

[C]

I would say over 50. Yeah. It's so high.

[A]

How many. What you guys do to coach everybody getting nutrition?

[C]

Because most, like, even my friends and people in my life that I know, they just go to the Medis Bar, go to the. Or They're. They're like, can you just put me on it? And they just put them on it and it goes inappropriately. It's so inappropriate very fast to me. And I'm like, why? I'm like, wait, what you're. I'm sorry. I'm like, wait, what? You're on like 15 milligrams. I was like, why? I've trapped high. I was like, what? What?

[A]

You know, I mean, how much do you need of that?

[B]

Well, it depends on the person. I mean, some people maybe need 15 milligrams, but a lot of people need.

[C]

Right. Start low and go like, see where

[B]

you sleep during set. The person that works for the. Where they're still eating enough.

[C]

Right.

[B]

Where they are still getting nutrition, where they're still getting their hydration and they're slowly losing.

[C]

And that's a happy patient. Actually, that's a much happier patient when it's coming off slowly and slowly because you're not getting any of the side effects and you're only getting the benefits and you feel so good. And it's okay for it to happen slowly. You don't have to lose 20 pounds in like two weeks.

[B]

Where our toxins are held too right.

[C]

In our fat. Hello.

[B]

Rapidly lose weight. You gave yourself a humongous toxin.

[C]

Totally.

[A]

Right.

[B]

Then you'll see people get sick. Yeah. And you know, and have.

[C]

That's why they deal with complications.

[A]

Well, too much too fast is very, very problematic, whether it's the guy steroids going crazy high or this crazy diet and going crazy low. The amount of stress and strain on ligaments, tendons, joint, and then cellularly and everything else.

[C]

And again, it's the majority, not the minority.

[A]

And when you lose that much weight that fast, it's not good up here either.

[C]

Oh, my God.

[A]

Terrible.

[B]

And otherwise, that doxing toxic, at least

[C]

when you look at it. Right.

[A]

Yeah, but neurologically, how. How negative is that? I mean, can't that just throw you off all the way around?% thinking all over the place, inability to focus. I mean, that's kind of what I wanted to talk to you too about, because we. I've never had this discussion with either one of you. And what I really learned the past probably six months is because I've always been so into fitness and nutrition and now cellular stuff and everything else. I haven't done one thing, neuroscience, neurological, nothing. And I realized what I've been missing and. And. But you know what it kind of took was looking at myself and going, man, why are you such a dick, like, constantly? And why are you having an inability to focus and why are you so stressed and why do you sleep so bad? And then I started to piece this stuff together and go, man, it's because you're not working on anything up here. You're so worried about this that you're not really that healthy because of your stress, because of all this.

[C]

It is one of the top three things that is dealt with in any of my patients. Like, we. The neuro piece is huge for.

[B]

But I would say most doctors.

[C]

Yeah.

[B]

Ignore it. Right. People don't come to us sometimes. Brain fog and things like that. But most of them are coming to you first. You know, ed or. Or weight loss or fatigue. Those are the number one people. So. So, you know, when you look at longevity clinics, how much work are they doing looking at cognitive function? I think it's very.

[C]

It's totally unk.

[B]

We're not doing measurements.

[C]

Right.

[B]

We're not getting baseline measurements. So people are following baseline measurements. We do in my clinic, but most clinics don't, you know, and see. So I think it's. Even in our longevity world, it's. It's a little bit.

[C]

I agree.

[B]

Neglected. Now, obviously, if you get the rest of the body healthy, the brain is gonna be healthier, but there's a lot more pieces to that.

[C]

Right? Yeah. And you wanna. And I think, like, again, I'm all about averting the crisis and being proactive. So I'm looking at a lot of these biomarkers, baseline. And if I see. If I see red flags in the. In the workup, the initial workup I'm doing, then I'm gonna do an even deeper dive. Right. And then that way you can really regret. And when you catch the patients early like this, you really can reverse. Reverse or regress what's starting, you know, because the first point of, like, the first step is really just this, like, sort of development of neuroinflammation, right. Before it becomes vascular, before then it becomes neurodegenerative, like these three steps. So getting them at that point is so important, right?

[B]

Yeah.

[A]

And I want to get into the markers and the physic you look at, you go to the doctor or whatever, they're not really asking you, well, how's your stress? Well, how's your sleep? Then they're looking at basic BS markers that really aren't that important. And if your stress level is so high, it's increasing inflammation, cortisol, who knows what else, and the effects that it has on everything that you're doing, sleep especially. And so like what I've tried to do is really integrate beyond my prayers, which is so important to me is like that peaceful walk and appreciation of, of the, my surroundings and of nature and the vitamin G of gratitude, which actually is important.

[B]

Yeah, right. Yeah. Journaling, gratitude, meditation. We, we talk a lot about how the value of meditation. It's hard to do. It's hard. But now we have cheer ways of doing meditation. Right. There's things like brain tap, there's tools that we can use to help us.

[A]

How big of a priority should this be though? I mean, shouldn't it be number one?

[C]

I think that, well, you, you said this a bunch in a bunch of her awesome posts that she, she's talked, that she posts. But basically when you look at the pillars of health, right, and like, you know, movement, you know, movement, nutrition, stress management, sleep is your foundational pillar. If you don't have that person sleeping, how are they going to heal? When you sleep is when you repair, regenerate, that's when your glymph, the glymphatic system is working during that night to drain all the garbage and the toxin and all the horrible things out of your brain. If you're not sleeping, getting into good deep sleep. And so that's not going to function and work properly. Right. So just that just by getting your patients to sleep, right. And giving them good advice on sleep hygiene and you know, really working on that circadian clock is hugely important in reducing neuroinflammation. Right. Just that alone, you know, we can get into all the cool stuff, but God, you gotta address that, you know, and that, and that does overlap with, you know, stress management and cortisol dysregulation and getting that cortisol curve to like behave the way it should, like come up and then slowly come down and then cortisol passes the baton to melatonin and you can get to sleep. Like all those things are so important, right?

[B]

Yeah. And you'll add that, you know, when you look at sleep, it still does come down to some of the foundational stuff when you, you have to have optimized hormones. Right. So, you know, again, if you're like, yeah, you need both men and women need progesterone to sleep and then need more testosterone to help sleep.

[C]

So.

[B]

So we have to not forget that the basics. If somebody comes in your office and you want to work on sleep, you still have to start with some of the basic things. Right, right. Do they have the tools necessary. Yeah. You know, to sleep. But yeah, obviously those pillars are so, so hugely critical. And when you look at now all these companies coming out, like I get Instagram all, all day long. I'm sure you guys do with just order. This is your, you know, $499 lab test.

[C]

Right, right.

[B]

And so now you got, you have literally every marker that's like, what do you do? What do you do with it?

[A]

Right.

[B]

And you know, and you can run it to chat GPT. And that's great. And Chad does an amazing job. But chat doesn' on all these other pieces and how it all fits together. And you have to be careful because chat will go to the very worst scenario. On those labs. I was having sensations. I received some issues like, you know, like kind of multiple two things. I ran it through Claude, literally by the end of the conversation, Claude's like, you most certainly have metastatic cancer. As you see somebody.

[C]

That's why. But that's why people come to us free because of the, hey, I'm with you.

[A]

Some of that.

[B]

And I'm like, I think it'd be interesting. But you have to be able to weed through it. Right. Because they have to go to the worst case scenario. More like liability perspective. So you've got to sort of piece back to the person to go. It also will give you 500 things to do.

[A]

Yeah.

[B]

And you know, we know people can only do so many things at one time.

[A]

Well, and like a lot of side effects can really pinpoint to like 20 different things or 30 different things. So you have to be aware of that too. Yeah, I used to do that where I'd look at that and be like, oh my gosh. And I'd be in these panics and then I'm like, dude, just.

[B]

Yeah, you're making it worse.

[A]

You just make it worse.

[C]

I always tell my patients, I'm like, really? You graduated from Google medical school? And in, in a day. Congratulations.

[B]

I do love. My patients are trying.

[C]

No, it's, it's fine. But they need us. That's why they have us. And how that I'm Going to realize

[B]

we are, we aren't going to replace a good health coach, physician, whoever it might be to, to sit down with you and help walk you through things. Right. You know, back to the brain health, obviously. Yeah, those pillars are so foundational, but so is everything else. Right. The micronutrients are so, so critical. The hormones are so critical to brain health. And then I, I think that we aren't, we are forgetting the building blocks that, that the brain and neurons in general need, like plasmalogens. I would tell you 90% of doctors have no idea what a plasma.

[C]

90. I would say 99. What do you mean?

[B]

Like, you know, we, we in off

[C]

world, we have no idea.

[B]

I would tell you like in our longevity docs group, they don't know who is. Nobody knows what a plasmalogen is.

[A]

Well, what is it? Tell everybody.

[B]

So plus is a very specialized type of phospholipid. And you're, you, you make them from your peroxisomes. You can't eat them, you can't take them in. Well, you said.

[C]

Well technically, but not that. Not what?

[B]

Right, so, so basically your proxim, your cells make these. And what they are is think about them as the kind of protective layer on all of your neurons.

[A]

Right.

[B]

So, so they are, I like to think about like the, the insulation on all the wiring.

[A]

Okay. All right.

[B]

First thing that happens, if you get sick, you get a virus, you get stressed, you lose those plasmas. Now if your mitochondria aren't perfect, your peroxones aren't perfect, you're not going to replace them. And now what happens? Your body actually starts taking them away from you. So it's trying. Now take these and, and you know, and you start demyelinating. So the brain will suffer, your nerves will suffer. Almost everybody as we age gets plasmylogen deficiency. Some people more than others. Okay, so because we can't just all sudden make your body make more proxims that make, you know, we can do things that will help, but we still have to replace the plasmologens. Almost all of us need plasmology replacement. And because you really can't just eat them and get them to your brain. There's only one. So Prodrome Sciences came up with a precursor that can go to the brain and become a plasmaogen.

[A]

Really?

[C]

And they extract it from egg yolk, right? From the yolk. From the yolk.

[B]

Well, no, it's, it's, it's a synthesized. No, it's. So it's not choline. So Egg yolk has choline in it, right? So lots of times it's put together with an egg yolk. So you can take it with. You can just take plasma itself, which is synthesized. It's a synthesized specialized phosphatel ethanolamine that actually is, you know, has to be. Has to be made. So the precursor has to be made that can convert.

[C]

So it's synth. It's synthesis allies.

[B]

Yeah.

[A]

So, you know, prodrome science.

[C]

And then that crosses the blood brain barrier, that which he's describing, what gets across the library.

[B]

Measure plasma levels on people and if you do not have enough plasmas, I don't care what you do, it doesn't matter. You're not going to repair it.

[A]

When would those start to decline? Is it different for everybody? And is there a good world? Is there lifestyle things?

[C]

Well, all of us, with the exposures that we've had and how many vaccines we've had or how many like exposures to Covid, probably many of us are at a plasmology and deficit.

[A]

So you could be young and that could.

[B]

Yeah, oh yeah. Oh yeah. I measure all the time. Young people. And I've had young, you know, some of my really young patients and long coveted people. Everybody. Okay, yeah, we. But yeah, I mean, in a perfect world, probably around 50, we all decline, but in our Covid octop, much earlier than that.

[A]

So the only way to fix this is this. Is that a product people can buy or

[B]

technology? It was actually developed as. Really as a. As a drug for treating these kids who have a disorder where they can't make plasma outens. They all died by the time they were six.

[A]

So would you notice this cognitively?

[C]

Yeah, well, he's done like she. Betsy's, you know, is in his. What is it, like your elite practitioners group? Yeah, but like he, like I spend a little time with him. He's unbelievably brilliant. And I mean, the scans that he. He's done what, thousands of scans where he shows like the gray and white matter changes in the brain, like before even in like a person. Like one of our colleagues did this. Did you? Yeah, because I saw one of our, you know, said whatever, our very good friend. We. I saw her scan and it's insane. Like what she looked like prior to plasmogens and then after.

[B]

Right. We say you could grow a new brain. You absolutely now have a whole series of patients where we've shown they have, you know, 20% loss of gray matter, they have white matter lesions, and now we've fixed them right. Over time.

[A]

So this is totally fixable.

[B]

And.

[C]

Yeah, it can be. Yeah.

[B]

Well, again, all now, since 2006, a group of. This is. Dr. Good. Now a group of patients with Rush University of. Who have the APOE4.4 gene.

[A]

Okay.

[B]

As long as those people's plasmaogens stay high, they did not develop.

[A]

Really.

[C]

I've said this before, and I like it when I lecture and stuff, but like, even one mild or asymptomatic case of COVID and even a young 19, 20, 21 year old, one case, there are brain, like permanent brain changes like on the mri. Like, this has been, this has been published a bunch of times already in the last, like, year and a half, two years. And that there's decreased cerebral, cerebral blood flow to the brain. There's changes on the gray matter, the white matter. And this is from one asymptomatic or mild case. So imagine what's happening. And so if you can get these plasmologens into you, right, this is going to be, you know, such a saving grace for so many people. And, you know, we're, you know, we talk to people like, all over, you know, the country that, you know, specialize in different things like, you know, Amy, who does ALS and things like that. I mean, you have no idea what that we're seeing. Like, she has 19 year olds with ALS, 21 year olds with ALS. She has like, we've never seen neurodegenerative diseases like, presenting in such young ages.

[B]

We're like a complete, like, we're different world.

[C]

We're in a complete, like dementia. Parkinson's has gone up by 50%, like from the beginning of the pandemic to 2023. When you look at the trends and, you know, when you, you can verify this when you talk to the neurologists that are actually looking at this and, you know, the functional neurologists are people like, like these brilliant people that are running ALS clinics and things like that, like what they're seeing and again, how it is a true age accelerant because you're seeing such earlier presentations than like, we ever have before.

[A]

I've had Covid seven or eight times, so I'm probably really bad there. Yeah.

[B]

So you really have to be proactive and you have to. So you can look at markers like P Tau, you know, and, and Galectin 3, and you can look at these markers that tell us, yeah, your brain is in trouble. People see those numbers and immediately doctors tell you have Alzheimer's. No, you have a neuroinfl brain that we can change.

[C]

That you can and you can and you'll. And once you get a lot of these things on board that you're doing for neuro enhancement, neur. You know, you know, bathing that brain with all the things it needs, it go. You can reverse the mars g. Okay. Which is really cool.

[B]

It's really cool. And all the typical doctors do is go, oh, you have this mark, you have early Alzheimer's. Let's start you on these.

[C]

But not even that. Or they're like, nah, they don't even do. Or they're just me. Or the waiting for the symptoms to catch up with the biochemical, you know, with your, with your biochemistry. Right. That's what's so infuriating. Right? Because you can stop it.

[B]

And it's gonna need to be looking at these things. And you know, even, you know, we do wabi wabi actually using machine called neurocatch. Now that actually can show when you start losing some energy to your brain. Right?

[A]

Okay.

[B]

So think about the first. The first thing that happens in neurodegeneration is it's an ATP deficit, which is why. And you know, ketones and those kinds of things are so helpful because they're going to increase energy to the brain. But you can look at a marker called a P300 wave on these EEG tests that show you even really before you see P taus go up or things like that, you can see the patient, the brain is losing energy, it's losing ATP, it's declining in function. And you know, there's norms for age because we sort of assume everybody's going to decline. And we really shouldn't be assuming that. Right. We should be doing the things to be neuroprotective. So we really. I. I agree with you. I think the brain gets sadly, really neglected in our world for a lot more. It's in body composition and, you know, and sex drive and everything else. And the last I, you know, the last thing they really think about really is. Is the colonies.

[A]

It's so easy to just go, oh, I'm stressed so I can't think or whatever and ever.

[C]

That's the excuse. I'm like so stressed or oh my God, it's my hormones or. But no, it's not. It's really. Maybe that's a little part.

[A]

Yeah, that, that too. I was gonna say it's either, oh, I'm so stressed or oh, I didn't sleep good.

[C]

And women that are like in their late 40s, it's always like, oh, no, it's because I'M perimenopause. No.

[A]

Yeah, well, because we just look for an excuse to tell ourselves it's kind of defined or whatever and it's okay.

[B]

We need to be looking at these things and people.

[A]

Yeah.

[C]

Because you can really save these people. Like you can really decrease morbidity.

[A]

I do not buy into that. Oh, it's inevitable. Or oh, as you get this age just gonna have a.

[C]

Definitely change the course of that person. You know, health span for sure.

[A]

And the point in, in this whole thing and, and everything we do is never accept what someone says that. Oh, that's just what's going to happen. Because it not true. I mean there's certain things that are inevitable, but you can certainly mitigate, prevent or protect. Right. I mean in all of these. I hate that. And it's kind of like with the plaque in the arteries, you can't reverse it. You c. Most certainly can.

[C]

You can.

[A]

Yeah. And, and all of these things they say you can't, you can't.

[B]

And then it's this acceptance that this is normal for age. I I don't know. I'm going to bring MRI scan. It says normal atrophy for age. You're like, what your brain should not drink. Right. There's not normal attributes. There's not normal for age. There is normal. Optimal and not optimal.

[A]

Right.

[B]

There's not normal for age. And that's how we look at every marker. Testosterone, you know, even blood, Even your blood work. Even blood work. Right.

[C]

Yeah. The ranges are based off of your age.

[A]

Yeah. And I hate that too. Like testosterone levels are based on what the average.

[C]

Right.

[B]

Like how healthy.

[A]

Like, I mean how many people do you get coming to you? And they're like, like in range and they're in the 200.

[C]

I have young death. I have 30 something year olds like that, 20 something year olds like that.

[A]

So let me ask you then, why do you think that I don't know the last five or ten years that the averages have just gone down so much and why at such a young age we're seeing lower levels of testosterone that are just some of the things I see without steroid. With steroid use, I expect it it. But without I'm seeing some of these and I'm like, what the hell is happening here? What's the problem?

[B]

Well, certainly environmental toxins.

[C]

Yes. I was going to say endocrine disruptor number one.

[A]

What are some of those that just exactly.

[B]

Glyphosate.

[C]

Plastic.

[B]

Yeah, plastic BPAs. But beyond that there's a little bit of this Unfortunate demasculation of men. Right?

[A]

Yeah.

[B]

That we, you know, it's actually not okay to be masculine anymore. Right. It's called toxic masculinity. And actually we would like boys to be boys. We would like them. Yeah. Okay. A little bit more aggressive, A little bit more. That's what they're supposed to be doing.

[C]

Yeah.

[B]

When somebody keeps telling you that's not, don't act that way, don't be that way. That's not really what boys were designed for. You don't have to be impolite and rude, but you, you, you should still be a man, right? You should still be. Yeah. You know, I, I want my 18 year old to have a little bit more aggressive than my theory. And, and you know, so I think there's unfortunately now, and when, when you don't reinforce that with, you know, more sports and more, you know, these, these sort of interactions and you're just sitting or playing video games, that's not going to improve.

[C]

Disaster. Health.

[B]

Hormones. Hormones has got huge reduction outside. You need to be, you know, you need to be a boy. You need to be so I, I hate this whole topic.

[C]

That's a good, such a great point. Amazing.

[B]

It's sad.

[C]

I agree.

[A]

Frustrating as hell.

[B]

So, you know, it terrifies me for my boys because it's always being down. Right. Oh, you know, you can't act like that. You can't do that. You know, boys are supposed to be, you know, in school not being able to sit still and you know, I mean, that's just boys and it's okay. And we should foster that and learn how to teach them the way they should be taught, which is moving and active and doing things.

[A]

Absolutely.

[B]

So, you know, we really have unfortunately created a society where we want low testosterone. It's better, more passive and look, and

[C]

you know how unhealthy that is for you.

[B]

It's terrible.

[A]

It is literally like one of the things I despise the most of the, that gets thrown in our faces. And what I see and what they try to tell you is how you're supposed to be, which is the polar opposite, how we were designed.

[C]

An amazing, amazing point that Betsy brings up. I mean, I will also say added to that is like the lives that we live, you know, like the, the constant stress, the constant going.

[A]

You think like stuff like that is a problem. Constant looking at screens and in a.

[C]

That dysregulates your cortisol. Like. What do you mean?

[B]

Animals now.

[C]

Yeah. And then when you're. And then the lack of sleep Too like you produce testosterone in the wee. Early morning of the, you know, we. Early hours of morning. I can't talk. But. Yeah, like, that's huge. Right.

[B]

And so speak to Covid's effect on.

[A]

Yeah, please. How was that affected, the level like that? I'm curious.

[C]

Well, the spike protein has a very high affinity for the testicles and. Or and the ovaries and.

[B]

Okay.

[C]

Yeah, it's really impacted. I mean, I've never seen so many men, so many young men with such. Every. I would say nine and a half out of 10 people come in my office. Not with like, even just my regular, like, patients that aren't seemingly coming in for like long Covid or something. They're testosterone deficient.

[B]

Yeah.

[A]

Really?

[C]

Like, people just coming in to help me with like, you know, gut stuff, GI stuff, whatever, you know. Or like some other, you know, that would.

[B]

The rise in infertility.

[C]

Yeah.

[B]

On both male and female.

[C]

They have noticed nobody makes testosterone.

[B]

So many of my young female patients have lost their cycles.

[C]

Dysmenorrhea. Yeah. Amenorrhea. Agreed, agreed.

[B]

Or an ovulatory cycle anymore. You've been crawling has been huge. And again, even, of course, people who've got a few, you know, didn't get horribly sick, but they got Covid a few times. We are seeing this.

[C]

Yeah. Really so common.

[A]

Is there a type of diet that's having a negative effect too, on. On testosterone levels?

[C]

I mean, like, I mean, just the stands of it. The syringe.

[B]

Yeah.

[C]

Terrible for you. Well, what is it? Yeah. High fructose corn syrup. It's literally in every. Like, if you look at a label that's like one of the first ingredients on anything that's packed.

[A]

You're telling me the labels with 20 and 30 ingredients aren't good?

[B]

Yeah.

[A]

What you're trying to say, you think it's like eating that chees cake factory menu of my.

[C]

Yeah. Protein, protein, protein. And like. Oh, but what about like, let's. I love the cholesterol thing too. I feel like it's coral too low. Oh, my God.

[A]

You know, they had my cholesterol down in the 30s, my LDL.

[C]

And I panicked and go back to the brain.

[B]

The job's not happy. He's like, look at this. No, they were.

[A]

Oh, this is great. This is where he wanted you.

[B]

And I said, what?

[C]

No, no, that's like your rate limiting. Like, you know, that's the reliming stuff for all of your hormones, like to produce all your hormones and your glucocorticoids and all your stu. Like that's insane. Right. And then, you know, Betsy can talk more about too. But Dr. Good now he shows that like the low cholesterol correlates with lower brain volume. Right.

[B]

We're seeing smaller brain volume. People who have. So. So we absolutely know that we don't want to push cholesterol.

[A]

Doesn't. Don't we need like fats for cellular membranes and things?

[C]

Yeah.

[A]

You know, I told you this before, but I lived in that low fat diet even though I was coaching against it for like 15 years. And I believe that's probably why I had some of the heart problems that I had. Cuz when I flipped like the pyramid now.

[C]

Yeah.

[A]

So I went from like 25 grams of fat a day to 130 is what I eat now.

[C]

Yeah.

[A]

And I'm. My HDL went up 40 points.

[B]

Wow.

[A]

And my ability to.

[C]

That's amazing.

[A]

Oh, it did. It went from the 40s to. To the right at 80 in like two to three months of switching and doing all of these animal fats and you know, pissed off. I'm for not eating grass fed butter every day and the things I cook.

[C]

Yes.

[A]

But having like these whole good foods and prioritizing protein and fats. So I guess my question then for you guys is on the way that the food has flipped now because some people still have this inability to understand the needs for fats and the things that are prioritized now as we know they should be for you on a normal diet that you feel is good. Do you feel like that is where we need to be? And then carbohydrates would be on the lower end or how do you guys structure or find a. And I know it's different if you're bodybuilding or something or training for something, you need a little bit higher carbs. But in general, normal people, how do you prioritize macros for your diets?

[B]

Well, I love the new pyramid. If you remember, the first pyramid was designed for the, you know, the companies like Kellogg's.

[C]

Yeah.

[B]

You know, I mean that's really where it came from.

[A]

Yeah.

[B]

It had nothing to do with health. It came with keeping these big companies and big money happen. Right. So we know that this is a much better way to go. You've got to be prioritizing proteins and fats and have carbohydrates on the lower side. Now there are people who do need more carbohydrates despite even if you're not in the bodybuilder road. And I think one of the things is looking at timing of carbohydrates to appropriately utilize them, you know, correctly. And we, we, we, we still, our, our body still likes glucose, right? So, so it still is a good fuel source. You know, fats, fats and ketones are, are a faster, cleaner way of making energy, but glucose is still a useful way of making energy going through oxy fluoration. So I think that we, we forget that, that you know, the zero carb diet, you'll actually, you know, people who are just following a ketotic diet forever, you will lose metabolic flux. You will actually start to see a decline in cell health and in mitochondrial function. Yeah, the mitochondria are like to be able to switch fuels. The healthiest people can switch between, between a glucose fed state and a ketone fat fed state. And if you never do that, you'll actually see over time mitochondrial function decline.

[A]

Okay, so you, that's what I was going to talk about was the metabolic flexibility aspect.

[B]

If you're going to do it, if you're going to do, you know, if, if you, if you say I feel great on ketone diet, but I have patients who do you really need to cycle in and out of it.

[A]

That's what I thought. And that's where I was kind of going structurally for me, on the changes, I've gone like 40, 40 protein fats and 20 carbs. But you know, how much I train. So I've kind of been thinking, yeah, I probably need a little bit, a little bit more.

[B]

Right.

[A]

So I've tried to bump that number up and I'm just playing and testing with stuff, you know, and I think that people that train a lot need more carbohydrates. And so then that poses the question, which kind of carbs do you think that you would recommend and what should people stay away from that are causing a lot of the problems?

[C]

So. Well, I was gonna just say, you know, piggybacking off protein fat, which are great, like understanding, like you have to have a good understanding of the type of fat. Right. And what exactly fat you're taking that's really important, right, because people are like, oh, well, this is saturated, this is unsaturated. But what is it? What is the fat? And like patients, like I am still careful with my APOE four fours and my APOE three fours. And you have like a fat, how much saturated fat? Yeah, they can have. You have to be careful because you don't want to like, you don't want to amplify that gene. Right. So you have to be Careful. So like, and, and Betsy does too. Like we check an APOE and everyone. Right. Because if you want to be able to like, take care of your patients properly, that's like a good gene to look at.

[A]

What gene is that for everybody listening?

[C]

The apoe.

[B]

Yeah.

[C]

APO lipoprotein.

[B]

The fat transport protein.

[C]

Yeah, yeah.

[B]

So if you're a 2, 2, a 2 3. A 3 3, you have a normal risk of dementia. If you're a 3, 4, it's increased. You're 44. It's market 20.

[C]

Yeah. 12% increase risk of like dementia.

[A]

Okay.

[B]

And. And because the. The fat transport for the brain is. Is altered, you need to be a little bit more careful with how those people are eating.

[A]

I see.

[C]

Yeah. So you want to be careful with that. It also impacts heart cardio. They're both. It's like, people always like, focus on dementia, but it's cardiovascular health as well. So you want to just like, you know, it's really good marker to have like, you know, Betsy and I were talking about enough. The biggest, like snips. People like get 20,000 snips. And you know, like you're, you know, the gene testing when you do epic, you know, because not all of them. You're. It's not every one of them that's, you know, that you're necessarily manifesting. Right. And you don't know what, you know based on your epigenetics, what's going on with those. But there are certain mutations like apoe, mthfr. We talk about that later.

[A]

Yeah.

[C]

That you want to, like, know so that you could take better care of your patients and do a lot of preventative medicine about. Around. But anyway, so what I'm saying is, is the fats. I love the fats, but. And then we said it briefly too, like seed oils.

[A]

Yeah.

[C]

That's like really important. Like, people have to like, understand like what that is.

[B]

That. And they. That 3:6 ratio. Yeah. Really critical longevity source.

[C]

Yeah, yeah.

[A]

Right. Yeah.

[B]

When you're in a loss, your Omega 6s go very high and that ratio gets obscured. It is a very good longevity mark marker.

[A]

Yeah.

[B]

An inflammatory marker.

[C]

But. But the thing with the sixes, and this is what I've learned, is that those are adulterated sex. Right.

[B]

They're like. Right.

[C]

We get really good. Right.

[B]

You need.

[C]

That's. Yeah. So like when you supplement sometimes you could be doing a little bit more harm to the ratio. Like, that's why, like, you have to be careful with unadulterated sexes. Two threes and making sure that ratio is. Is right.

[B]

Type of omega 6. Yeah, yeah. Letic chondria. Actually use arachidonic acidic and arachidonic acid. Those are mega six. Yeah, but.

[C]

But we get the bad. We don't want the bad sexes.

[A]

Right.

[B]

The good. So that's where this, those sea oils comes in.

[C]

Yeah.

[B]

You know.

[C]

Yeah. And I mean, that's. They're in like, if you look at the label even like, they're like, oh, but I'm eating organic tortilla chips. Yeah. And I'm eating organic. It's like, do you know how like you look at that? It's like sunflower oil, safflower oil, palm oil, you know, like on all these things that say they're organic too. So you have to lay it under your sense.

[B]

Right?

[A]

Yeah.

[C]

You don't know what you're getting.

[A]

Why do you think I never eat out?

[C]

Yeah.

[A]

Once to twice a year maybe if queen, you make something. But now she.

[C]

But it's like building. It's like getting the patients to build the plate, right? Yeah. Right. And then, and then building the plate based on what your biomarkers are. Right. So somebody might be more cardio, metabolic and also need like low glycemic index, like a more low glycemic impact diet and stuff like that. But like, yeah, I, I'm so such a proponent of having this like higher protein, good fats, you know, and like. Yeah, like, maybe not as much carbs, but like good complex cards, like no refined sugars, like none of the garbage, but really good complex carbohydrates, you know, to fuel you.

[B]

Yeah. So carbs have gotten a little bit too shamed.

[C]

Right. I like carbs. I mean, I'm a carb girl. I'll tell you right now. I like, I say you go the

[B]

way you train and, and have trouble keeping weight on, but you may need a few more carbs.

[A]

Right? I, I don't like, like crave carbs or anything like that, but I do.

[B]

Yeah.

[A]

I get most of mine from like vegetables and fruits and, you know, I do the pomegranate juice because I know for the heart.

[C]

Oh, the palm. Yeah, yeah, yeah. I love the palm. Yeah.

[B]

Did you do, did you do the testing or the pomegranates into your elephant

[C]

separate the good superfood.

[A]

Yeah.

[B]

Pomegranate.

[A]

No, I do that juice every day. And.

[C]

Yeah.

[A]

But I don't. And I, you know, I'm Italian, of course, so I ate some pasta all the time when I was a kid, but I don't crave.

[B]

It.

[A]

But I do try to keep it very structurally sound of what I do take in. And I can't stand these fears of fruits and the things that people say. I'm like, brother, just don't eat pounds of fruit a day. But you do need some, you know

[C]

and if you have a problem just again, lower glycemic. Yeah, like low, you know the ones that have a lower glycemic. Berries and. Yeah, yeah, the berries. Yeah, exactly.

[A]

So what are some other ones? Like I, I know everybody's always going to say sweet potatoes so we know that is going to be one. I tend if I do do it. The purple ones, the amazing, amazing make me feel heavy for some reason. But I still have them sometimes because they are so good. But what are some other ones? So we got vegetables, fruits, sweet potatoes. What about like rice or oats or anything like that? What are you guys thoughts on?

[B]

White rice can be a very like, you know, I'm a rice child and very interestingly you, one of the ways you can sort of lower the glycemic impacts of rice is to cook it ahead of time, keep it in the refrigerator and then reheat it.

[C]

Same same with potato. With a white potato.

[B]

Yeah.

[A]

Okay.

[B]

Or even, even pastas.

[A]

If you eat them by cook in the fridge.

[B]

In the fridge and then reheat it, you've lowered the bite.

[C]

Better for you.

[A]

Okay.

[B]

So but I think you know, white people always think well the brown rices are better actually white rice is probably a clean.

[A]

White rice is better, I think. Yeah. Okay. All right.

[C]

I like my jasmati. I do like a jasmine basmati combination. It's delicious. Yeah.

[B]

Such a good like you mix that with your meats and some sausage and,

[C]

and that's so good. I love over like I, I love a good like gluten free version of like overnight like whole like overnight oats like mixed with like chia seeds.

[B]

I'm like soft date aspir with that kind of.

[C]

I'm sorry Dave, but I do, I think it's okay to have in moderation.

[A]

Like ate so much oatmeal for so many years I can't even eat it at all.

[C]

But instant oatmeal. I wouldn't say instant oatmeal. I say like the whole oat.

[B]

I mean the biggest about oats. No, but I'm just that they absorb a lot of toxins. Oh it's really the toxins, they're absorbed.

[A]

I swear.

[B]

Be a little careful with oats because they do their really, you know, like, oat milk's probably one of the most

[C]

toxic we talked about.

[B]

So with that, I know it really.

[C]

But unlike an oat, like it said,

[B]

oats love to absorb toxins out of the soil.

[A]

I did like 15 years of 3 servings

[C]

have them in moderate. This my boy. Like having. It's all like about moderation.

[A]

Moderation. Because, you know, we all get on

[C]

because you have to be able to enjoy your life, lifestyle, and be able to have things that make you happy.

[A]

It's easy, though, when you haven't had something for a while and then you eat it and then you want it all the time.

[C]

Right.

[A]

You know what I mean? I. I've been that type to where I'm like, oh, just, just. Let's not just get out.

[C]

Right. You need GLP1 for that.

[B]

Yeah.

[C]

Yeah. If you had a GLP1, you'd be okay.

[A]

I think sometimes too, the older you get, the more control that you seem to have. Or maybe it's just my lack of desire to eat because I get so busy to work or whatever. Probably. I swear to you, though, the foods I prioritize now are all things I wouldn't touch like two years ago and that I can't live without them now. Let's see her avocados.

[C]

Oh, I was gonna say, avocados are wonderful.

[A]

You know, I eat. I went in. So I. I went into the kitchen one day and I told Queenie because I'm like the spur of the moment guy where just cars will show up, just whatever. I just. Just comes and I'm just like that. So she's used to it. And I went in there and I know she. She's prayed for years about me just stopping the. Because I've had eating disorders from modeling and being in bodybuilding and just as a kid, and it just never went away.

[C]

Yeah.

[A]

And I was. You know how I train.

[B]

Yeah.

[A]

15, 1600 calories a day is always eating for years, burning 4,000.

[B]

Listen, you're. You're doing this long endurance.

[A]

Oh, yeah. So I went in one day and I said, okay, I can't. I can't live like this anymore. I'm gonna try all this. I tell you. I don't like, like salmon avocados. We're going to Whole Foods. Pounds of meat. And then I started going down the line. Elk, venison. Had them all. And I can't. This is what I eat every day. Avocado. Whole eggs. Not just egg whites.

[C]

Full yogurt, that. Can we talk? Can we go back to the egg White versus whole egg.

[A]

I love this discussion.

[B]

Oh my God, the egg.

[C]

You feel you finish and then we'll go back to that because it's really important. And I have this argument with like my. Even my friends or my patients like all the time.

[A]

So I was eating 10 to 12, just egg whites. Bites never.

[B]

Because bodybuilders, you're just massive protein. All right?

[A]

No calories, full fat yogurt instead of low fat. And just the disgusting nature of the low fat, not to mention all the strip out of it every day.

[C]

So you were eating the low fat yogurt?

[A]

Yeah, the fat free, plain. Terrible.

[C]

Oh yeah.

[A]

The. The most dreadful thing in the world. And. And then I have to mix all kinds of in there to make it even palatable.

[C]

Right.

[A]

And then all of these grass fed meats and beefs every day. Fatty fish. But then I do like to mix in this for you and everything. But these are the things, like I'll sit down and have damn near a thousand calorie meal because the avocado I'll do. I used to do 80 grams, then I did 100, then it was 150, then it was 200, you know, and so it's a good range. And then the Ezekiel bread, I wouldn't touch bread. The good cheeses, the pecorinos and those things. All these things I have now, I wouldn't touch any of them. Wouldn't touch all the things I listed. None of it. Now that's all you'd ever say.

[B]

But when you come from your world of, you know, you know, I work with a lot of bodybuilders, you know, when you come from that world of this such disrupted eating, eating, it's, you know, you know, where you're trying to massively just eat tons of protein but no calories and you know, terrible nutrient loss that occurs with that.

[A]

And you know, you know, I don't eat chicken. I don't even touch it. I don't even like it. I'm so sick of it. And then I realized this sucks like it does. Aside from chicken thighs, I think it all just. It's so dry and bland. Yeah, they're good. That's what I'm saying. That's the only one I even touch.

[C]

Chicken Hazard Delash.

[A]

Yeah, they're freaking great. But I wouldn't even look at them right. You know, because I was terrified. I was the exception. Yeah. That. That doesn't exist.

[C]

Yeah.

[A]

So it just opened up a whole new world for me. And I say that to humanize myself, but to Tell others, like, if you're living in that fear or whatever. I'm the leanest. I've been. Aside from steroid use.

[C]

No, you look great. Do you feel great?

[A]

Yeah, I do. I mean, aside from matter irritation sometimes with all the work and everything. Yeah, I feel phenomenal. And I'm not miserable. One. Hungry all day, right?

[B]

Yeah.

[A]

You know, eating 13 servings of vegetables a day, which is what I was doing. Snacking all day on peppers and onions and that crap that's I like. But you don't want to eat that all day, you know, And I think that a lot of people lack either. They're not eating enough because, like, we're talking about, they're busy, they're scared, they want to lose weight and all of that. And I think if people ate more, they'd realize they burn more, right?

[B]

Yeah.

[A]

But that's what I want to talk to you guys about, because we talked about this. I like to measure my breath in the morning to see how my flexibility is and what I'm burning and everything. If you're a constant, what are you measuring it with? The lumen.

[C]

Are you using the lumen? I used to use that a lot. Yeah, I practice.

[A]

Yeah, I love it.

[C]

You like it?

[A]

I do. Just because I like to know, okay. Sleep effects, if you wake up, fat burning and everything. But I like to see, I take what I did. If I mix something up the day before and test it and see, did I eat too late, Did I do this? Did I have a little extra this? And compare it, and some days it's just off. But you talked about in class, we had that if you wake up really hungry in the morning or whatever, you're kind of in the carb burning stage. Can you. Can we talk about what it means when you wake up? If you're like sugar carb burning as opposed to fat burning, how we want to be, what that all means, and how we stay metabolically flexible. Because I think people don't know.

[C]

Yeah.

[B]

I mean, really, you know, when you wake up absolutely starving, Right. When you wake up in the morning, you are just like, oh, my God, I have to get to food. Likely you produced a lot of cortisol, you know, overnight. You. You spiked up glucose and insulin overnight, and then you crashed it. Right. So you were in this completely, you know, just glycolytically starved state. And your body craves something right away.

[A]

Right.

[B]

Don't crave something immediately to try and get some glucose back. You just had this big spike of glucose either maybe because you Ate a high carb meal before the night before, lots of times because of stress. So we get these big cortisol spikes at night and we see this all the time. Right. And you can do. You can monitor with cgms and clc. Yes, we do that scope in the middle of the night. Right. And you know, and then what happens? You know, cortisol spikes, glucose spikes, insulin spikes. Now what happens? Blood sugar drops out, you wake up, I'm like, I'm ravenous. I need my. I need glucose. Right. Yeah. Whereas we can keep ourselves in a more. More, you know, ketonic state a little bit. So by eating something like a protein before you go, basically you blunt that effect. So even if I have. If I have a little bit of protein on board, even if I have this cortisol, glucose, insulin spike, it's gonna be blunted somewhat by having this little. So sometimes I'll have people do a little bit of protein so they just don't wake up completely. Right. You do a small protein load before they go to bed and to keep them more stable through the night.

[A]

Yeah.

[B]

You know, and. And now CGMs. You know, I think the loom is great. We can do so much now with CGMs too, to help people figure this out.

[A]

Yeah.

[B]

What is happening to them?

[A]

Y.

[B]

You know, how are they keeping their glucose nice and stable?

[A]

Yeah, I do. So I take the yogurt, mixed protein powder in it and then a little bit of fruit. And that's like, I have a couple bites before bed and I. Tablespoon of almond butter.

[B]

Don't need a lot stabilize these. Yeah, we.

[C]

We do like a tablespoon of like a nut butter or like, maybe if they have like a little bit of a whey protein. A whey protein, Like a whey based protein powder, like with a little bit.

[B]

And those are the people too. You got to say, you know, we need to work on. On why are you Cortisol.

[C]

Right. The cor. Right. Like, I mean, it's really amazing because we do CGMs. I've been doing them for years in my practice. And it's really unbelievable the amount of patients you see with these really high glucose levels, like throughout, especially women. It's insane. It's actually really crazy. And then. Yeah, of course. And then because of that driving, the cortisol and glucose are married. Right. So like you're. And then you're becoming. You're breeding more insulin resistance. And I love the CGM because it's really. This is really unbelievable to. To me too. And Fascinating to me rather that like you can have like two people right. With like even maybe similar glucose spikes and like in, in you know, you know, readings on the cgm. But their bio, their biochemical individuality is so different that like when you pair them with certain foods, like one part like that C might have to be paired differently than I have be paired so that you avoid those. That's why I love like the cgm because of that amazing biofuel like that

[B]

like my partner Dr. Hussain sent me, he was doing a CGM. He sent me, ate a half a banana, half a banana spike.

[C]

But not for someone else.

[B]

I can eat banana and I'm fine. Right. So it's really interesting to have different things. All my spikes for somebody and not somebody else. Really individualized.

[C]

And that's where precision medicine comes in. Because again like everyone wants everything to be boilerplate and wants it to be like oh, a protocol. Oh well if this person is having all these spikes and having issues in the more like what we were just talking about, what you intervene with and what you give them could be totally different for you know, patient A versus B. Right, right. And so you have to have that understanding and knowledge of like yeah, I

[B]

know what has a neuropathy and is him going to see is a little bit high and he has like a cookie every day. I go, you're gonna have to stop the cookie. I go, I'm not gonna stop my cookies. So I put a CGN off cookie.

[C]

Didn't. Didn't do it.

[B]

It was like, did nothing to him. But he would have these horrible cortisol spikes at night.

[A]

Why do we not want glucose spikes or too high of ones?

[C]

Because that's going to bleed in. That's going to bleed into your.

[A]

I know the answer. You're looking at me like what's wrong with you? I want them to know I know the answer.

[C]

Okay, sorry, I wasn't trying to be.

[A]

Look at it be like what happened to you, Bill?

[B]

And this is my high glucose spike. High insulin.

[C]

Right, right, right.

[B]

And then insulin glucose is not the evil thing insince learned.

[C]

And then eventually the receptors get desensitized to insulin and you have it more nervous. Right.

[A]

So what's on going gonna is is it just foods that causes or stress or combinations?

[C]

Yeah, like stress is huge. I mean and even like going back to stress like cortisol just regulation is probably the biggest. I think one of the biggest drivers of like why we have insulin resistance and then. And that's also messing up your sleep and Whatever. And like. And then that messes up your gut microbiome because when you have high cortisol and you feel stressed, you want comfort food, and then you're going back to like, refined sugars and bad garbage. And then your gut microbiome is getting screwed up and you're becoming more constipated. Like, there's just like. And then your vagus nerve is like, becoming super floppy. And like, there's just like so many things, like, happening.

[B]

Alcohol.

[A]

Will that cause it too?

[C]

Alcohol's terrible.

[B]

Alcohol is just a pure glucose load.

[A]

Right?

[B]

At least when you're eating a cookie, you've got a little bit of fiber. You've got maybe, you know, other things that something.

[C]

It's a direct. It's a direct toxicant to your mitochondria.

[B]

Yeah, cute.

[C]

Mitochondria, girl. Direct. Toxic. Toxic.

[B]

I honestly have this argument with my children who are all know, teens and 20s about, you know, drinking, because it didn't like my 20, I was like, you. You know, I can't socially interact without drinking. And I'm like, you can really?

[A]

I used to think the.

[C]

Or just have drink and make sure you're like, it's. And when you're drinking, like, not on an empty stomach and not like it's like, it's how you do it. And also I feel like certain alcohols are. I know it sounds ridiculous. Are a little better for you, are cleaner for you like that.

[B]

That we need to just get. And I don't know how you hit the young people. I think our generations are now getting a little bit more like alcohol. Just bad. I don't need it. How do you hit the young people? How do you hit the frat bros who still, you know, party every weekend and get drunk off their butts? I don't know how to change that behavior.

[A]

It's hard.

[B]

It's really hard.

[A]

Hard.

[B]

They are too invincible to tell you. You know, every time you're doing that, Even though you're 18, it is really messing your brain up. I don't know how we impact that population.

[A]

It's tough.

[C]

And your liver, it's very.

[A]

And your gut trying to do is give the information that doesn't scare people. Like, when I deliver it, I'm like, listen, I've done all this. This is what it is. Do whatever you want because I'm not going to lose sleep. But look, this is what it does and this is what it's going to end up when you're older. Sometimes it's just how you say it. Because if you, if you bring it across in a fearful way or a lecturing type of way. Shut up off. That's not going to happen to me. That's not going to happen to me. I start telling stories about that's happened to me and the way I convey it.

[B]

Stories are great. Right. People actually hear real life. It's like your story has gone a long way to change people. Right. You know, so I think stories are a really good tool to do that. Yeah. But it to me it's one of my number one. Our medicine needs to be started earlier.

[A]

Yes.

[B]

Right. We need to get people in their 20s interested in looking at this stuff. Yes. You know, looking at their markers, understanding that you might. My 26 year old son has horrible lipids. It's just his, his genetics. Right. If I can address those now and really get him optimized there, you know, his LP as high as apob.

[A]

That's where I was going.

[B]

Yeah, we can save him a whole lot of trouble. We're seeing people now. We're trying to backtrack. If we can start getting out to the younger generation. And you know, I hope just when I see, you know our age have kids that they, the kids start picking it up. Right.

[A]

You know, we gotta teach like parents and things that they need to look at in their kids because like you said LP Lilly had I known that right here maybe I never.

[C]

They don't even check an insulin level on like Jason's that you're like an insulin level is not even checked.

[A]

That's insane.

[C]

And I tell like a lot of. I'm like make sure they check an insulin level. I'm like tell them to do advanced cardiac like advanced cardio like in a cardio cure. Like pet them labcord.

[A]

Yeah.

[C]

I'm just look at these other inflammatory biomarkers. Like that's the thing that's a big fallacy. Like everyone thinks the LDL is the biggest deal. I'm like look at. It's all these other inflammatory biomarkers that

[B]

like are driven stress.

[A]

Right.

[B]

Alcohol does not become problem until is oxidized. So you don't say hi any stress even LP is not a problem until. Do you have oxidative stress? LP member has some protective properties. It exists for a reason.

[A]

Right.

[B]

Otherwise all you LP people would have died off.

[A]

Right? Right.

[B]

It's there because it actually has some protective role against viruses and things like that. There is some protective role to it. It in itself is not a horrible thing. It's oxy of stress along with an lp. So if you have a perfect, you know, redox and no, it doesn't matter. Your LV is not going to get kill you. Right.

[C]

But everyone thinks it's going to kill them and they're still going to get, you know, plasma phisis or like try to, you know, they're trying to do all these things to lower it, but they could be working on the other thing. So that. Right. Like. Like myoproxidase is a great oxidative stress marker biomarker.

[B]

I Fen. Right. Oxygen.

[C]

True.

[B]

And doctors don't know that. Right?

[C]

Yeah. And. And, and. And fe. And not ferritin and mpo. Like I am not kidding you. I've never seen. Seen so many elevated MPOs. Like post covet especially. And it was funny one of our. My colleagues such an oxygen. Yeah. And that's a good marker to like follow as like you see that coming down that you're like, wow, this you're. You're in a better place. Right. And like I have one of like a good friend of ours, actually a you know, dear colleague of mine who, you know, does the advanced, you know, lipid panel, like the cardio IQ or whatever. They do the MPO all the time. And he's like, yeah, I stopped talking the mpo. I'm like, why? He's like, it's elevated in everybody. I'm like, what do you mean?

[B]

I'm like, no.

[C]

And I'm like, no, no, no. I was like, that's okay. I was like, you're gonna use that as a marker. As a marker to show that like things are improving. Right? And that you're addressing the oxidative stress and that you're getting. Right. It's like. But yeah, that's what, that's what's happening. Like people just don't want to deal with it. They're like, why is everyone's high now? I'm not. This is wrong.

[B]

I'm like, no, it's actually not great marker that nobody.

[C]

It's like, no, it's not.

[A]

You know, I think that that cardiac IQ is one of the most important

[C]

panels and not even the Cardiologists look at L.P. little. Looking at some of these like an

[A]

apple myself every six months sometimes. So I can. Because I'm really dialed into mine. So. And then for people listening particle sizes apob.

[C]

Yeah.

[A]

Little A. All of these things that they don't look at or. But the. That's really important.

[C]

Correct.

[A]

I mean the other stuff is like secondary in my view. Total hdl, ldl I want to ask one more thing before we shift on the glucose spike stuff. So what if? What, what if. So let's say we've got a meal on the plate and one of the things I've learned to control that if you have carbs on the plate, is to eat the protein first, then the fat, then the carbs, and then control the spike. You guys agree?

[C]

Because that is gonna. That's impacting your gastric emptying too. Yeah, like how fast you're emptying and moving is.

[B]

Some of you guys have heard me talk about tros, which is a. Oh yeah. TROS is a glucose molecules hooked together and it has zero glycemic impact. It's also really good for your brain. So it actually, actually they're using it now as a drug to treat Ms. So trulose is a really interesting sugar in that it, it actually completely blunts. Not completely, but pretty significantly blocks glycemic impacted foods. So if you're gonna eat something that's a high carb meal, eat your protein first. But one of the things you can do is just drink like a little lemon water with Trailos, which tastes like lemonade drink that you're gonna see, you know, and this is where CGMs are fun, right? You can see almost no impact on your blood glucose. So I love using.

[C]

How much trailos do you have then? Like ad.

[B]

So I like, I have them do like five grams.

[C]

Five grams? Yeah. It's like that good little hack. She's. I've heard her tell me this up the tummy.

[B]

Honestly, this is amazing. Plus it has so many neural benefits. So it's such amazing sugar to use. It has zero calories, zero glycemic impact, Has a few calories, but zero glycemic impact. And it's neuroprotective and it's blunts this, the cortisol response and the insulin response. This is an amazing.

[C]

Everyone should just have that before dinner, use it like a glass of it

[B]

before dinner and it's yummy, right? You drink lemon water with tres. It's like, drink a little yam before your dinner. It's huge.

[C]

I love that.

[B]

So I add that to my protein shake in the morning. You know, I do five grams at least three times a day. So it's huge.

[A]

So morning time. What do you, what do you recommend for people, like high protein mornings, fat mornings? What, what's a good thing for people to take in? Because that's, that's one of the most confused.

[C]

What should they be eating?

[A]

Yeah, like because some people say don't eat breakfast at all. Some people want you to eat, eat this tremendous 12 from Perkins or whatever. Like what, what, what do you guys recommend for morning consumption?

[B]

Well, I think you need to have at least a 12 to 16 hour fast.

[A]

Right.

[B]

I think I agree. So if you, yeah, if you eat.

[C]

Except for very ill patients, I don't fast them because I feel like their, their body.

[B]

I used to do longer fast and that's where CGM helped me a lot. I'll show you my very worst. Be someone with a. When you have somebody like my, you and I who are thin don't know, you know, all of us who are thin and don't have a lot of extra when we fast. It's a little bit of a stress to our body. Right.

[A]

It harms me.

[B]

So my glucose, you should see how it spikes on my fasting days. So, you know, so I think that, you know, if you're eating dinner, you know, the best thing is to eat dinner earlier. But that's just so hard with most of our life.

[C]

These studies that show that too, like I heard this, yeah. There's. I watch this whole woman, Shadita, dinner

[B]

while it's still light up. Really. You know, but it's hard. I don't get work for the sun

[C]

or like as the sun's going down

[B]

or something, you know, so, so if you ate dinner 8 o', clock, you know, you wouldn't want to have something to eat until at least 10 o'.

[C]

Clock.

[B]

Yeah, 10 or noon. Right. So I do think that, that it's not so much important as, you know, do you eat breakfast? Do you not if you ate dinner at 5 o', clock, then probably it's a great thing.

[A]

The timing, it's not so much.

[B]

Right.

[A]

It's a timing thing correctly, whatever you want to call it.

[C]

Yeah.

[A]

Eggs meal number one said eggs.

[C]

I, I was saying that's what you.

[B]

That's by far, that's the very best eggs. I of all my patients try to eat three eggs a day.

[C]

That's great for your brain.

[B]

And that's where the whole egg white. Right. Egg whites are all the choline, all the good stuff is in the yolk, is in the yolks. Egg yolks are the most valuable nut.

[A]

I have four a day. Yeah, Guaranteed four a day.

[C]

But everyone's like, but my cholesterol is going to go up.

[A]

Oh, they have no effect on cholesterol. And have people that say that have no understanding or grasp of what kind of cholesterol Is coming from egg. And

[B]

you look at.

[A]

It's my favorite food in the world.

[B]

Choline is. Almost all of us are deficient in choline. And so you need so much choline. And eggs are by far one of the richest sources.

[A]

I think if you. If you forced me to say, Dylan, you have to pick one food you have every day, you only get one, it would be. Probably be eggs.

[B]

Yeah, yeah. I think, I think that it's always going to eat.

[C]

I might want pizza.

[A]

I might do this. When I was still smolling P. I would have said pizza too, for sure. Right.

[C]

Food ever. Yeah. Like, I have patients do eggs with some avocado.

[B]

Oh, yeah.

[C]

Like, it's like the best.

[A]

I started to put avocado because I just have it on toast and eggs and everything. And a couple days I didn't have time and I was like, I got to get more nutrients and so I started putting it in like the meats that I was cooking and stuff and.

[C]

Oh, my gosh, with the egg.

[A]

No, just so cook. Like I'll cook like three quarter pound of elk, for instance. And then I would put 100 grams of avocado in it. Dry cooked it, mixed it in. Yeah. Sometimes I'll drape an egg over it too. A couple. It's so good. Okay, I got. I want to. I want to talk about your staples, like, supplement, and I want you to give me five staples and I. And I understand, like magnesium, vitamin D. I'm.

[C]

You don't want to talk about magnesium.

[A]

No, let's not talk about. I'm talking like a creatine or something else. A different type of supplement that you say is good and then give me a couple that are just like unnecessary. Like, you know where I'm going to. Going with like BCAs or something like that.

[C]

Like off the beaten. You're saying more off the beaten track. Yeah. People aren't like thinking about that they're putting in that we. They should infuse into their day.

[A]

Yeah, yeah. Because I think we know certain vitamins and minerals that we absolutely have to need. I want to get more out there a little bit with you.

[C]

All right, you want to go.

[B]

Yeah. If we're not going to talk about all the basic things that you have. So you need to be vitamins. You need different. Yeah.

[C]

Minerals.

[A]

We've covered that so many times.

[B]

Kind of off the beaten path. One is going to be ketones because I can reduce inflammation with ketones. I can give myself brain energy, muscle energy. I can, I can. I mean, ketones Will honestly you could, you could live on ketones. I mean so it, it, it goes so far in all these certain pathways. Right. It rests my mitochondria. Everything I'm going to talk about is going to be focused on. I'm going to try and keep my mitochondria as healthy as possible. Okay so it's gonna be then probably alpha ketoglutarate urolithin A is gonna be high. So those are really you know if you start looking at ur especially higher dose effect on mitochondria. So huge. Alpha ketoglutarate underutilized, very underutilized in terms of mitochondrial function. It's essential for mitochondrial health. You know I will put cycling high dose birmine because high dose birmine also has so and, and we're talking about gain up into like a 20mg dose and cycling that is so beneficial for mitophagy. I think when I, so if I put together those four things I'm going to keep my mitochondria pretty humming honestly

[A]

Ultra stack, you know I take a heavy dose here.

[C]

I do it.

[B]

That's because you get it for free. That's the rest of us have to pay.

[C]

Yeah. Why do you got it for spray? No, they are. That's your sponsor.

[A]

Yeah, I do like 1250, 50 milligrams

[B]

I think an optimal dose honestly. I know they're coming out anything personal does more in the gram range but I actually think like when my people are sick all up to 1500 milligrams.

[A]

Oh yeah.

[B]

You need at least probably a gram a day.

[A]

Honestly. I think so, I think so. They, they do 500 but they five they say a gram would be the, you know but it'll kill you.

[C]

We've been talking about you in our group too like using a gram at least for like the last two like last year and a half or two. Yeah.

[A]

I take a, I take a capsule, a four full stick powder thing and then a gummy every day. So it's 12.50.

[B]

I think one of the for you biggest problems in a little bit in our world and we do this with peptides and we do it with something underdosed is underdosing things. Yeah right. They're not dosed because of cost and you know and see profiles like you don't want to put on a label

[A]

but then it takes four of these

[B]

because now someone's going to take eight. Right.

[A]

Yeah.

[B]

So, so the, the biggest issue like spermidine. Our initial recommendations for 6mg if you go back and look at the studies that was doing nothing. Yeah. Now we know we probably need closer to 20 milligrams. I think URLs. An A is like that. I don't know that 500 milligrams is probably enough. If you're super healthy and everything's fine, if you have any order or things like that, you probably need a gram alpha ketoglutarate. You need at least 3 grams. The dosing is 500 milligrams. I mean, you know, so I think we're, we're. You know, when you look at packaging and you look at what viability wise labeling has to do, we are under utilizing a lot of really good, good.

[A]

Oh, I agree. I see it all the time. A lot of products that have like six, seven ingredients, right?

[B]

Yeah, those are probably the, the worst, Right. Oh, this looks great. It's got all this cool stuff in it. But look at the numbers. All micro do. Yeah. Because that's the only way to actually sell it and not have, you know,

[A]

the Loop 332 dose used to be like tiny microgram that people recommended. And I see all these studies about 50 milligrams. I mean, what.

[C]

For what? Not.

[B]

I'm not a fan of for what blue people.

[A]

Okay. Yeah.

[B]

I, you know, we can have a whole discussion on SLPP why it's bad for. Do that one later.

[A]

What's your top?

[C]

So I love this product called OG Ozonated Glycerin. Tell me, because I just think it just, you know, can kill so many birds with one stone. But O. It's basically like, you know how you have hydrogen peroxide? It's a glucose peroxide. So instead of like throwing like, you know, basically like giving, you know, giving it. Someone like causes a fire. This is like sort of like lighting a candle.

[A]

Okay.

[C]

And like it basically the ozone is like diffusing and getting to where it has to go, whatever. And if Betsy's saying that, Come on now. And it, it basically, you know, really pushes right across the cell membrane, gets into the mitochondria, like does its job. Right. Because of the way it's designed because of, of this glucose, you know, because it's a glucose peroxide. But what's really cool about it is when you ingest it. And the Japanese have done like, like dozens and dozens of study. They actually were studying ozonated glycerin for diabetes as like a cure for diabetes because it really helps fasting glucose levels.

[B]

Okay.

[C]

Which you wouldn't think because it's a glucose peroxide. It's like sort of counterintuitive, but because of how it behaves intracellularly and what it does, it causes like this specific type of gradient that causes glucose to be taken up and it. And basically you can utilize glucose more efficiently. But anyway, you heal a lot of stuff with it. Yeah, so. So really what's cool about it is, is when you ingest it orally, it gets absorbed in the very first part of your duodenum, in the first part of your. Of your small intestine. And so systemically it has a lot of impacts because it obviously can get everywhere across the membrane barrier. So it can really help with. With a lot of things from like, different pulmonary diseases, like people with bronchiectasis, like refractory tb. It's been used in like, different neurodegenerative disease states. And you can nebulize it, you can inhale it, you can take it orally, all these different things. So it is around so long it's been around. So the. Right. So the backstory, the backstory is so interesting. So when it was presented at the conference that I went to like a year ago, basically this very, you know, brilliant physician scientist back in the late 1800s, he studied it immensely and he was curing everything like, well, these basically, you know, diseases back then that you didn't have anti vax for, you didn't have penicillin, like, you couldn't cure any of these things. And he was like getting people better. All these different viral diseases, bacterial, you know, infectious diseases and things like that. And he wrote, wrote like 15 different editions to like, his work. Right. And I guess he passed away in the beginning of the 1900s. And in it's literally all of these editions and like, all of his works that he wrote, like all these things that he wrote about, they've been sitting in plain sight at the Library of Congress. So a bunch of these guys then like a bunch of these physicians that are like super cool and like cowboys and like, like to learn all this stuff in the ozone space. They got these works and started like, like, and started reading all of his, you know, books, and they were able to figure out like, oh my God, this is how we're gonna dose. This is what we're gonna do all the things. And it's really safe. Like, you can't really like overdose it. And you can actually give it IV and you can combine it with DMSO iv and it's actually fantastic what it can do for like all different things. Especially autonomic dysfunction, you know, cancer, you know, other con. Complex chronic illnesses. But I love it just add as something to build immune resilience. Right. And something to support your mitochondria and if you want to. And also it has. It has activity against viral lipid, lipid, enveloped and non lipid envelope viruses. So. And most bacteria. And so it's really great, you know, antimicrobial. If you want to get it into your gut, to do good stuff in your gut or kill any, like, bad bacteria or bacteriophages, like Covid, you have to like, combine it with like a chia seed or something so that you can push it into the gut because it gets absorbed so quickly in the small intestine. But yeah, we use a lot. I use it intranasally every day, actually, to prevent myself from getting sick. Like, I do one spray in each nostril, like twice a day. And then if I feel like maybe something's coming on, I'll use it more. I mean, just dilute it down. And then we use it topically with DMSO. So like in a very. In a 4 to 1 solution or even like a more diluted solution. But the 4 to 1 solution is great for, like, anyone with different, you know, dermatitis. Like dermatitis, like psoriasis, eczema wounds. Yeah. Like weird, bizarre rashes. Anything that's like hot and erythematous, like, it takes away. And it's a very, very potent analgesic. And the last thing I'll say about it is it does not disrupt the gut microbiome. That's what I was saying with Japanese. They studied this extensively and they showed that it only kills the good bacteria and not the bad, which I think is super, super fascinating and cool.

[B]

Oh, like, here's the bad bacteria, not the good.

[C]

Yeah, sorry. Thanks. That's why I had. That's why she's sitting next to me. It kills the bad, not the good, and it leaves the good away. Like when you study it, like Even like at 30 days, 60 days, 90 days, like, you might get a little drop in the. But all the bad are gone. And it really doesn't really mess with the good bacteria.

[A]

Fascinating. I'm building a list of stuff that I need to start getting.

[B]

And the platinums. Right.

[C]

And then maybe I should quickly talk about the. The antibiotics. I do like it a lot. Forgot. So the antibiotic is basically, you take healthy donor stool and you autoclave it. You autoclave the crap out of it. No pun intended. And you're left with like 13 to 15,000 different bioactive compounds, which are your metabolites that the good bacteria make. So you're getting really healthy donor stool with the right bacteria, the right balance of bacteria that make all these beautiful postbiotics or metabolites. Right. And so why I like it so much is because when you use probiotics, right, that's like, you know, yeah, I think a pro probiotics, they're good and for some reasons, but I think of them as sort of like Taurus, right? They're like passing through your gut, you know, and they're giving you those things like temporarily where this is sort of like you're not depending on the actual bacteria probiotic. You're just showering that person with all these amazing metabolites. And they've done like, you know, they have studies that, you know, show like, you know, its efficacy and different things that it can help with. But it does seem to really help patients like with autoimmune diseases with the leaky gut, you know, because it's really helping with that short chain fatty acid replacement and all the other metabolites that are going to help seal the gut up and also providing some of those bioactive compounds that the good bacteria in your gut want to feed off of. Right. So I have a lot of good success in, you know, basically when I'm dealing with patients for gut restoration and repair, like with using that product and it having like a good impact.

[A]

One more question then before we finish. What would be one for each of you that you think is often used and is completely unnecessary?

[B]

Well, you bought a branching amino acids. You know, honestly, branching amino acids, I know people and if you're fasting and you want to get some branching amino acids, go ahead. But truly the branching amino acids need a full spectrum from the protein. They need all the amino acids to really do their job job and not kick one, you know, sort of overflow one pathway and not another. There's really zero evidence that you're not better off just eating protein than taking your silly branch chain amino acids.

[A]

What about the eaa?

[B]

And I think EA can be the essential amino acids. Can be, can be useful. Okay, so I, I, I have no qualms against using the essential amino acids in people. And we will see deficiencies in those A lot of times when we look at micronutrient testing where I do need to replace those in people, especially who have been sick or older people who. But all you guys who are taking your BCA is just eat some fricking Protein, Right.

[A]

So a post workout, just drink protein.

[B]

Eat the protein. Drink, right?

[C]

Yeah, eat the protein.

[B]

Yeah, eat the protein. It's just silly.

[A]

Okay.

[B]

And again, it can actually create. When you look at what happens metabolomically, you'll see a different metabolomic pattern in somebody who takes BCAs and somebody who ate protein and it's not a healthy one.

[A]

Really interesting. Okay.

[C]

I don't know.

[A]

You don't have both.

[C]

Well, I just had one in my head and it slipped out and I went away.

[A]

There's just. The problem is, is there's a lot of nonsensical marketing too and things that are.

[C]

Oh, I know. Well, it's silly sort of.

[A]

No, nothing silly.

[C]

But I, I think people are such suckers that just. That don't know better. Right. That just take a regular multivitamin.

[A]

Yeah.

[C]

Because all you're doing is just creating expensive pee. Now. Let me qualify that. Hold on, on. So like most multivitamins out there, right. Just have the little bit, littlest bit of each thing, right. The littlest bit of all these different minerals and vitamins and you need such a high dose of each one of those things. Now granted, in our space and some companies that we work with, they make or what they call it a good multivitamin. There are some good ones that have really good high doses of zinc, selenium, you know, like all the minerals, your vitamin D A, you know, all those things. Things that makes a difference, right? But I would say when I, when my pe, like what do you mean? I'm not taking my most. Like I'm like, no, I was like, you don't need that anymore, right? And like you need all these things,

[B]

these multi products that have, you know.

[C]

Yeah. They say they're not getting, you know,

[B]

I could take this one pill, has this and this and this and this and the line is way too small to do anything. Great marketing. Yeah, yeah, great.

[C]

Goes back, right. We had a whole conversation about this this past weekend, right. Like you have this cool product that has like all these different things, let's say for even, even mitochondria. But like it's of like each thing

[A]

and they try to tell you, oh because of the synergy between them. But there's such little synergy because you're getting a little bit of.

[C]

A lot of things take that into account in somebody that like doesn't have a good like gut microbiome, which most people do and they're not absorbing properly. I mean it just, it's just diluted and diluted products yes. But anyway, all right, that was. I'm not as. Not as.

[A]

Not a big create.

[C]

Not of Create. Not as creative and thinking of what supplement.

[A]

But actually, I've been arguing this for such a long time. Time. And if you're buying a 20 multivitamin, you're probably not getting much of anything. You're getting up 5000% of vitamins.

[C]

Expensive pee.

[A]

Yeah.

[C]

Expensive urine.

[A]

No. And. And it's just getting peed out, overdoing it on the cheap stuff and then not giving you anything of the important stuff is what they do.

[C]

Right.

[A]

It's just people don't know anybody.

[B]

Yeah.

[A]

They look at price tags and go, well, this one's 25 cheaper than the other. Well, there's a reason.

[B]

Yeah.

[A]

So. Oh, my gosh, you guys, I could go for another six or seven hours with you because. Well, I look at the clock and I'm like, well, how the hell did we go?

[B]

We were only gonna talk 90 minutes. What happened?

[A]

Wait, maybe that would B.S. but I.

[C]

What did we go for?

[A]

Almost two hours.

[C]

Oh, my God. That was so fun, though.

[A]

Well, I haven't had a fraction of enough. So I. I would ask you guys to come again when we can do this again, because this was damn fun.

[B]

Yeah. You and I talked about talking about some cool peptides and things like that. We'll do that.

[A]

Yeah, we got. Well, we got a million topics to go back to. So what's the good.

[C]

We do. We have a lot of topics.

[A]

What do you guys have coming up new? You both have books coming, right? I mean, what. What do you guys have coming? Tell me. And so we can tell everybody and share you with the world, please.

[B]

So I'm just doing a lot of lecturing, you know, so I'm hitting the lecture circuit. You can go to my site and find out those places. A lot of them are medical conferences, but there's a lot that I'm going to. That I'll be lecturing at. Asprey. I'm lecturing this Da Vinci conference, Da Vinci Mastermind. So these are kind of a more public conferences. So I. So if you guys go to my site, you can sort of find those things because I think there's a lot. Like one of my. I think both of our goals is to try and teach medicine and not just.

[A]

Yes.

[B]

You know, try and counteract some of social media that's become so. So overwhelmed with nonsense. So I think both of us are really trying hard to try and, you know, get a little bit more of a presence there. It's Always hard. You're good at it. We're not so good at it.

[A]

Yeah, we're gonna make you good at it because that's the point in doing this.

[C]

So I am hitting the lecture circuit too. Not as much as my friend Betsy, but I'm getting there. I'm like just slow. I'm like low and slow. Right. But yeah, I have some conferences coming up next month, like IHS and Calm, which were. So we're such a great conference. We love columns. And then I have a few in April. The. Is it the Advancement of Medicine? I always forget. It's ahm. Something. It's in April. It's on my website. And then also we have this Women's Longevity conference that we're speaking at in Turkey. And in my.

[B]

I'll be like, oh, wow. There are longevity conferences in Turkey especially geared to women. So be really interested in this.

[C]

Then I have the AOT coming up which is in May. So yeah, so I have some like, exciting.

[B]

So ourselves and Dr. Killer are putting together. I won't call a podcast, but a few little podcast like episodes.

[C]

Yeah.

[B]

Kind of doing exactly this between the three of us together where we really just chat about topics that, you know, where you can bring a lot of this support here. Different opinions.

[C]

Yeah. And we, and it's like relatable, you know, we're awesome.

[B]

We're going to be filming all four episodes of that.

[C]

And, and we really want you on as a guest at some point, if you don't mind. Would you, would you come on.

[A]

I would do anything for you guys.

[C]

So you're going to come on at

[B]

one of us called Mavericks.

[C]

We're called the medical Mavericks. Do you like that?

[A]

I love it.

[C]

What do you think of that?

[A]

Within reason. I would do anything for you guys, especially.

[C]

You're sweet.

[A]

No, I would, I, I really would. You. I don't. I can't ever really tell you what all you do for me because it's just. There's not words past. But I am always want to give the credit where the credit is due and anything of impact, you know.

[B]

And you know, Dylan, I've told you this before is I, I, you know, there's so much out there now in the social media world and I love that you are trying. I mean, for you guys. I don't know. Dylan's taking my course. He's learning. He's learning the science. You know, I love that you're doing that instead of just out there sort of spreading no, you know, stuff that.

[C]

And with, and with such Authenticity. You are such an authentic.

[A]

I want to know everything.

[C]

Yeah, but you're, like, the best.

[A]

Thank you so much. I. Look, I only know one way to do things. I'm only smart because I hang out with the smartest people in the world. I don't know.

[C]

That's what I said.

[A]

Yeah.

[C]

I do the same thing.

[A]

You have to. Yes, you can. You can never know too much. You always know too little.

[C]

Always learning. Perpetual student.

[A]

Yes. Yeah. I mean, I always say Michael Jordan didn't stay great by not shooting anymore. Practicing every day. I try to learn something every day.

[B]

And we always have to be willing to change our mind.

[A]

That's right.

[B]

Right.

[A]

That's huge.

[B]

Like, you know how we've done things like. Like, oh, I. That was stupid. You know, I mean, there's so many things that we look back on. Like, why would I do that?

[A]

I gotta. I could write a book just on the shit I've done wrong or set up right.

[C]

But that's okay. It's so funny because I. I was a competitive swimmer growing up, and I swam D1 in college, but my coaches always told me I was really coachable.

[A]

Yeah.

[C]

Like. And I feel like I'm co. I feel like I can, like, basically parlay that into, like, any part of my life, you know, and. Cause I love being coached and I love learning and I love, like, exploring all these new things. And it's okay if I'm. And it's okay if I'm wrong.

[B]

Right.

[A]

I think the best things that we could have internally is accountability and humility.

[C]

Yeah.

[A]

Because if you have those, you can always accept responsibility for what you've done wrong. And when you do something good, you're humble about it and you just appreciate that people hear it and see what you're trying to say. When you start getting too big for your own, that's when things go wrong.

[C]

That's what I think.

[A]

You know, everything.

[C]

That's what happens with a lot of people, unfortunately. And.

[A]

And you. You have to.

[B]

I mean, there's supplements I was really get down on and then. And then.

[C]

Yeah.

[B]

And they're like, oh, actually, the evidence is not really praying away or our results. Yeah, we have the. We have the advantage of. We see the results in our kitchens. Right. And.

[A]

Yeah.

[B]

You know, it looks great on paper.

[A]

Right.

[B]

Looks so great.

[C]

But that's the point. That's okay. Because you're continually learning and understanding, so you. You know, so you're able to pivot, I think, and do the right thing.

[A]

Teachers have made the most mistakes. They Just don't make the same ones over and right.

[C]

You learn from it and then you change and you pivot. Yeah. You know, and that's okay.

[A]

You have to be willing to admit and fix and correct and then learn and teach. And that's what we try to do here.

[B]

Yep.

[A]

I thank you guys again for coming and seeing me, taking the time and doing this. And I like literally would do this with you every day if I could. I just, I value the out of this to the highest extent. So thank you.

[C]

Is mutual.

[A]

Yeah.

[C]

So much appreciate, love and adore you and.

[B]

And we're really happy because we all love left Hugely. Cold weather to come this year.

[C]

I know it could not have been more perfect timing.

[A]

Just it's an open invite the rest of the world.

[B]

Arizona seems to be protected.

[A]

That's why most part of the reason I moved.

[C]

Weird. It's sort of bizarre.

[A]

Yeah, I love it. And those early morning walks and tank tops in the winter are beautiful, let me tell you.

[C]

I'm sure they are.

[A]

I will put every single way to follow you guys and contact you in the descriptions. I will reiterate, reiterate. Boulder longevity, terrain, health and everything else that they do. Follow them. You will not learn more from more trustworthy and better people, I assure you. So that being said, stay tuned for plenty more to come. Dylan Gemelli, Dr. Elizabeth Yearth, Dr. Robin Rose signing off.

[B]

Thank you guys.

[C]

Bye. Thanks, Sam.