← The Hunter Williams Podcast
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- [00:01]
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Hunter Williams
Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world today. I am really excited we are going to do the BPC157 masterclass. So this is obviously one of the most popular peptides out there. It's one of the OG peptides that's been around probably the longest, at least in the research space. Definitely, I would say probably from the clinical side of things. Outside of the GLP1s is definitely one. Although it's not FDA approved, it's is one that a lot of people would like to use just because the healing benefits are so widespread and so effective. And I'm really excited for this one. If you're in the peptide space, you're probably pretty familiar with BPC157. A lot of times it's the first peptide someone will use. But hopefully today in the masterclass we're going to cover what you might already know about BPC157 as a refresher, but also some other stuff that you might not have been aware of in terms of what you can use it for to actually do so. I'm really excited for this one. I think it's gonna be really fun to dive into it. We'll see how long it goes. But before I jump into the slides, as always, make sure you're on the email list. That's the best place to stay in touch with me to avoid censorship. I just send out notifications of new videos and different things that I might be ruminating on or thinking about a few times per week. And then also too, if you want more access to me, the best place to do that is the Axion Collective. That'll always be on that little link bottom of my videos. You can click, it'll take you to my little version of a link tree and you can click on that there to join that. And then as always too now use the AI chat tool, which is free, to be able to just basically ask questions of any of the videos in my database. It will pull from the transcript of those and answer a question. So without further ado, I will share my screen. And today we're going to cover the BPC157 masterclass. All right, let's get into it. Today's going to be the BPC157 masterclass. You're probably pretty familiar with it, but hopefully today you'll learn some things that you might not have learned before. All right, what is BPC157? It's definitely not a steroid. It's not directly build muscle shift, hormones, spike testosterone, anything like that. What it is, though, is a healing peptide. Helps the body repair tissue faster. And when we look at tendons, ligaments, gut, nerves, blood vessel, liver, it does so much. What's cool about it is we have 30 years of animal studies. However, there are few fewer than 30 human subjects in published literature and there's never been a large randomized controlled trial. And that's what's interesting is perhaps out of anything that we've had before, this is one of the least clinically studied. But most human used peptides out there, whether you're talking about the oral version or the injectable version, this is pretty much one. If someone has used BPC before or has used peptides before, they've probably used BPC in some form or fashion. And so I think it's, it's very unique in the sense that some of these other ones, we have tons of human data on BPC1 7, we don't, but perhaps it's one of the best ones at doing what it does, which is mainly healing, amongst other things, to, to get a really good effect in humans. So very interesting look at the origins of it. Obviously, BPC, the BPC in that stands for body protection compound, which is a 15amino acid fragment isolated from human gastric juice by Professor Predrag Sikarich at the University of Zagreb. It was first disclosed in a patent in 1992. So that's what's funny about a lot of these peptides is they seem novel today, but what 1992 would be like 34 years ago that it goes back the luck Your weight is 1419 Daltons. That number on a certificate analysis confirms that you actually received bpc. And the reason it's unique is that it's has three consecutive proline residues create a rigid, unusually tough structure compared to most peptides. Most peptides evolve in stomach acid within minutes. And BPC157 remains stable in human gastric juice for more than 24 hours, which enables oral dosing. Although the oral we'll talk about that is more gonna be for gut health, which is nearly unheard of for a therapeutic peptide. Although there are companies that are working on different attachments to molecules that would enhance oral absorption. BPC is one that does seem to work pretty well when taken orally. There are animal studies to show that there's benefits beyond gut health for oral supplementation. Now how I see that play out practically, practically in humans, you, you don't really see it heal injuries if taken orally, but still works. So let's look at the mechanisms behind BPC when we're looking at how it works in the body. So unlike peptides that act on one receptor, BPC has no identified specific receptor in the body, although it nudges several repair systems simultaneously. The first one's gonna be the nitric oxide system. This is perhaps one of the biggest benefits that it provides to the body. It regulates blood flow and circulation, also delivers oxygen and nutrients to damaged tissue in the body. It also works on growth factor pathways. It signals cells to multiply and replay repair, including veg F and building new blood vessels. And then we have structural systems, basically proteins that seal gut lining, help cells crawl towards wounds and hold tissue scaffolding in place. And this is why it does so well to help with injury repair. And again, think of it less like a key fitting one lock, like some other peptides do. It's more like a general contractor who gets the plumbing, electrical and framing crews all working together. Let's go deeper on this nitric oxide mechanisms. Basically we have two routes to nitric oxide. Route 1 is via VEGF. BPC increases VEG FR2 receptors on blood vessel cells, which then triggers a cascade that ends in nitric oxide production. It also turns up the volume on our own repair signal without adding a new one. Also too we have Route 2 via Src Kinase. BPC activates Src Kinase, which frees Enos, which is endothelial nitric oxide synthase from Caviolin 1, which is its off switch and is confirmed independently by Clinical studies that we have. But basically, BPC regulates nitric oxide in both directions, pushing the system towards balance instead of just cranking it up. And again, that mechanism is pretty unique for such a small peptide. Let's look at some of the growth factor ones. We have growth hormone receptor upregulation. This is probably one of those things you may not have heard of with BPC157 that it actually upregulates growth hormone receptor sensitivity and tendon cells. The gene coding for the growth hormone receptor was among the most strongly activated after BPC 157 structure in studies. Basically, it makes cells more sensitive to growth hormone, which is the foundation of why it pairs so well with growth hormone peptides. And I want to take it aside there and really examine how pivotal that can be. And anytime time someone is looking to build muscle or put on size or anything like that, I really like using BPC157 and TB500 as well as an adjunct to anabolic growth, because what it does is it upregulates the cell sensitivity to growth hormone, which is then going to have all the downstream effects that we know growth hormone does really well. And the same way that L carnitine can help with androgen receptor sensitivity, BPC helps with growth hormone receptor sensitivity, which means we're gonna get more bang for the buck of the growth hormone or the growth hormone peptides that we're taking. And again, when we look at that, that means if we're taking Tesrellin or CJC or ipamilin or human growth hormone, when we use that and we have BPC in the system, we're gonna get a better response out of those things. And it has this one plus one equals three effects. We also have this FAK Paxilin pathway, which increases the activity of focal adhesion kinase, which is known as fak, and Paxilin, which are proteins that control how cells grip a surface and pull themselves forward. This is the cellular nuts and bolts of faster wound closure, which again, when we talk about wound healing, injury healing, BPC is gonna work really well to help with those. And then we have angiogenesis, which basically promotes growth of new blood vessels via veg, F R2 and other mechanisms and animal models of blocked blood flow. It actually sped up circulation recovery and increased vessel count, which again, in the grand scheme of things, is why it' helping so well for recovery from injuries. Let's talk about the anti inflammatory benefits, because although it's not directly an anti inflammatory, it is going to have some secondary benefits. That end up becoming anti inflammatory. What it does is it lowers TNF alpha, interleukin 6 and interleukin 1 beta. And unlike ibuprofen or corticosteroids, it turns down the destructive inflammation while leaving pro healing signals intact. And again it modulates does not suppress, which is pretty neat because a lot of those other things suppress directly and in the the, the way that they do that they end up having sometimes catastrophic consequences on other systems in the body. It also works on gut barrier repair. It increases the tight junction proteins Z, O1 and occludin, which strengthens the intestinal barrier. And the gut is home turf. It was discovered in grass. So again that's where it really came out of. When we look at the brain and the nervous system again this is something that I think a lot of people don't realize what it's doing. When we talk about the brain and then the central nervous system, it does interact with dopamine, serotonin and G systems. And an animal model is protected against brain and nerve injury. Some users also report mood or mental clarity changes alongside physical healing, though this is far less studied in people. I personally will say, especially as someone that has had a history of traumatic brain injury through concussions and playing sports. The first time I ever took BPC157, I wouldn't have said I was depressed by any means before I took it, but I got this mental clarity and boost of mood that I had not had in a really long time. And again, placebo effect maybe, maybe not. But I think for people that do have history of traumatic brain injury can be very impactful in that sense. What's interesting about that, and we talk about some of these things that modulate dopamine, they can kind of be double edged swords. And what I mean by that is if you look at the GLPs, we know that those are directly bunting dopamine, which for one person can be a godsend, meaning that they don't act as compulsive and they're in a better mood versus another person. It actually could cause them to be sad and feel depressed. And I have heard in rare cases some people do get depressed from using BPC157. I do think that might come from some of this interaction with dope dopamine modulation that it might just shift a person into a state where they don't feel as good. But for a lot of people, including myself, I've actually gotten a boost in dopamine and a boost in mood and brain function. From using BPC157 which again makes sense because when we look at these systems, even if it's just the anti inflammatory benefit that's going to help with those neurotransmitters that a lot of cases will help someone feel better. And again that it's kind of one of these things like this class today that I'm doing is what we know. But I think there's so many things that we don't know that downstream some of these peptides are doing. And again the breadth of BPC's 157 mechanism mechanism is what makes it very unusual but also very cool at the same time because again if you just look through those things that I just said kind of sounds like a Swiss army knife. It's doing so many things where it's a lot of peptides, they're having one effect and that effect could be good but we're not getting this multifactorial effect like we are with bpc. Let's talk about some of the animal evidence organ by organ and look at some of the predictions clinical literature, because we do have a lot of animal evidence. Let's look at tendons and ligaments. Basically BPC and rodent studies sped the healing of a cut Achilles or a cut Achilles tendons. It also improved load tolerance, reduced inflammation and counteracted corticosteroid impaired healing, which I think is cool for people that do have to take a corticosteroid. One thing that I've obviously seen in the literature and then also talk to practitioners with is that God forbid that you have to do a corticosteroid Using BPC alongside of it will actually improve the outcome of that. And it'll also usually suppress some of the negative effects from the corticosteroid. We look at muscle and bone, it is obviously shown to improve healing after cut quadriceps and crush injuries. And in rabbits a match gold standard bone grafting. The full they got full bone continuity within six weeks after using bpc, which is pretty cool. We look at the GI tract, it protected against ulcers from alcohol, insets and stress. It also healed every type of GI fistula tested. Also improved gut architecture in short bowel syndrome. And again I think for the gut it's obviously a wonder peptide. And then we look at the liver, heart and brain. Again not so much that we associate this with BPC with some of these things, but it also reversed alcohol insead liver toxicity. It also reversed doxo rubicin in heart failure, reduced stroke damage and Accelerated peripheral nerve generation. So again, very, very diverse in the benefits that we're getting. Obviously these were animal studies that we saw this. But again what makes it unique, it's not anabolic and it's not a painkiller. It is not directly grow muscle or shift hormones, does not blocks pain signals like ibuprofen. It reduces pain by addressing the underlying tissue problem which again I think if you look at peptides in general, it's such a unique thing that they are doing that is so cool. And then most peptides do not do one thing. BPC has shown activity in the gut, joints, tendons, brains, liver, heart and blood vessels all through a multi system mechanism. And again, no other peptide that we know of really has the ability to do this. And again, when we look at safety, there is a huge safety margin in animals obviously anecdotally speaking in humans too, which is pretty cool. Who is it for? Let's start talking about the use cases of it. And again you could probably extrapolate from what I've talked about but obviously the biggest one is soft tissue injuries, nagging tendons, chronic shoulder, elbow issues, lingering muscle strains. This is obviously the strongest real world case. The next adjacent one would be stubborn gut issues. So if you have bloating food sensitivities, insead issues from taking too much insets, inflammatory gut conditions, oral dosing of BPC157 alongside injectable if you, if you really want to cover your bases, works amazing. We also have post surgical recovery. You could even do it pre surgery leading up to about seven days from the surgery, but it supports the body's repair process after a procedure. Obviously you want to talk with your doctor about that, but I've seen so many people heal in such a smaller amount of time than they would have if they had not had peptides. And then also too for people that are interested in longevity, if you're already dialed in on sleep training and nutrition, adding tissue protective tools as a foundation before more aggressive compounds can be really good. And I'm a fan even if I don't have anything wrong. I wouldn't say that I use BPC all the time, but I do use it even if I don't feel like I need to a few times throughout the year just to help with my gut, help with inflammation that may be lingering, maybe there. And then also too what's really nice, if you're someone that's active in training, you're gonna recover a lot better when you're using bpc. Who should skip it? Obviously if you don't have the fundamentals in place, I would say don't use peptides at all, especially bpc. If you are not someone that is oriented, I'm not saying you have to be perfect, but if you're not oriented to living a better lifestyle, sometimes peptides are not going to be a panacea. Also too, if you're wanting muscle or fat loss, bpt, BPC does not do either. However, I would say if you pair it with a GH peptide, it is going to associate or assist the GH peptide in doing what it does alongside of resistance training and eating, eating enough calories and everything. But a lot of people think they're just going to take BPC by itself and it's going to grow this muscle. Not gonna happen. And then again, if you have nothing to repair, like I said, sometimes I'll use it. But there's no need to chronically use or consistently use BPC if you don't have anything to repair. I think you can do it cyclically, but again, it's not something that you need to be taking all the time if you're already healthy. Also too for people, I always just recommend if you do have an active or recent cancer, we don't know what we don't know. And there's this big debate over whether BPC causes or exacerbates cancer. At the end of the day, we don't know. There's data in both directions. There's data to show that it shrinks tumors in the lungs if people have lung tumors. And so again, we don't know. What we do know is it promotes blood vessel growth and then tumors rely on obviously blood to give them nutrients to help grow again. This is something that you should discuss with your doctor. Again, I'm not going to tell you whether or not to, but I would just say the best practices to probably avoid it. And I would say too for people that do have active or recent cancer, there's other peptides out there that I would feel much, much safer with. If you wanted to get the effects of bpc. I love bpc, don't get me wrong. But when we talk about active or recent cancer, let's say you're someone that is in that falls in that category and you're, you're really sore, your knees are sore, whatever. You could use Cardilax and kpv. And from what we know about the mechanisms of those, they don't seem to be any sense, in any sense pro tumorogenic, whereas bpc, it's kind of we don't really know at this point. And so I would lean towards that side of things. And there's enough peptides out there now where you can kind of get some of the benefits of BPC without having to use it. Obviously pregnancy, breastfeeding, we don't really know. I will say for people on blood thinners, BPC1v7 affects platelet function and interacts with anticoagulants. Again, just requires medical oversight. I would stay away from PPC if I was on blood thinners. And again, if you have an acute illness, sometimes bpc, if you're, if you have like a viral illness or something like that, some people like, can I take that? I don't think it's necessarily harmful, but again there's better peptides that I would probably use to help with that sort of thing. Now let's talk about dosing, because I think the dosing is pretty straightforward. But this could hopefully be a very good reminder. When we look at standard animal dose, it's usually 10 micrograms per kilogram. Obviously scaled to humans using the FDA's Alo, Alo metric scaling method ends up being around 1.6 milli micrograms per kilogram, which ends up for a human about 112 micrograms per day. Now I'll say from practical experience that's a little on the low side. And so most people are going to agree that the two 50 to 500 microgram per day dose is usually the best thing to do. So again, when we look at tiers 200 ish, 250 micrograms per day is really good for general optimization, gut maintenance, mild support, and again I, I like that dose for people that are just using it in the background. For me that's the, the times of the year that I'm just adding it in for recovery, not trying to address any specific issue. Tier 2 is gonna be the 250 to 500 microgram per day range, which is gonna be for active injury repair, athletic recovery, if you're really pounding your body, and then also for most stacking protocols with other peptides like TB500 and KPV. And if you do have significant chronic dysfunction or post surgical recovery under guidance, I think you do up to 500m per day. Honestly, I would say 1mg for me would be the upper limit of the range. Interestingly, I have noticed great benefit from doing higher doses of TB500 up to like the 5mg per day. Whereas for me, and I'm not Saying this, this can't be for someone else. But for me, beyond 1mg of BPC per day doesn't seem to have any more outsize effect. And again, what I mean by that is 1mg versus 4mg. I don't know that you're getting any more benefit of taking that extra 3 milligrams. Whereas the difference between 250 micrograms and 1 milligram, I definitely think you're going to notice a difference. And for me, the threshold dose seems to be 1 milligram. And so I always tell people usually that the rule of thumb for any sort of active injury or significant dysfunction is around 500 micrograms per day. And then you can kind of go from there. But again, there's no real evidence like beyond a thousand micrograms or one milligram that I've seen that shows that it's a lot better. And Sometimes even between 500 and 500 micrograms and 1 milligram, it doesn't seem that that much better dosing for specific purposes. If you have tendon ligament muscle issues, again, that's 2,50 to 500 micrograms per day. I like a four to eight week course of that. And again, you could do a loading phase if you did a higher dose for two weeks and then drop back down to a lower dose. For gut conditions, 500 micrograms twice daily on an empty stomach via the oral route and again give that at least four to eight weeks to do its work. Post surgical recovery, 250 to 500 micrograms per day for at least four to six weeks. And again, when it comes to surgery and some of these more chronic acute issues, I'm more of a fan of staying on the peptide until you get to at least 95 to 100% healed, rather than just cycling, cycling off at an arbitrary number. And then longevity and maintenance. You know that 200 to 250 micrograms per day and periodic blocks maybe two to three times a year for four to eight weeks usually has pretty good effects. Let's talk about timing and realistic expectations. Again, frequency and timing once or twice daily for injectable use and then splitting doses usually keeps blood level stabior. Excuse me, Blood levels steadier almost. I said steady and stable together and I called it stable. New word for you guys for active injury healing and for oral gut use on an empty stomach, on the first thing in the morning and away from meals. Again, timing relative to training is not critical. Don't Overthink it again. Morning and night dosing is completely fine for most people. They're not gonna stay up at night or they're not gonna get drowsy if they take it in the morning. When will you feel it? Usually gut issues about one to two weeks. It turns over pretty quickly. And again that's if you're doing the oral and I like the injectable on top of the oral for tendon and ligaments. Obviously this can be variable. Usually four to eight weeks is when most people will notice something because connective tissue has poor blood supply and rebuilds slowly. And then how do you know it's working? Obviously for injury you have less pain, more load tolerance, faster bounce back, and then for gut, usually less bloating, better digestion and fewer, fair, fewer flares. So again, just track deliberately, not just on, based, based on how you feel. Although it's good to do. You can track some of the subjective or objective blood markers on your blood work. Let's talk about cycling. Why would, why should we cycle at all? Honestly, the, the reasons to cycle are more theoretical than proven. Again, it's one of those things. I wouldn't say it's the best practice to use BPC 247 365. And again, it's not pure cause tolerance or receptor down regulation. Although practically speaking, again, that's from a literature perspective. Practically speaking, I do know that once someone gets into eight to 12 weeks, the effects tend to diminish over time. But again, the two real reasons to cycle anyway is again, we don't have any long term safety data. And cycling builds in a margin of safety against the unknown. And then most people use it for a specific healing goal. And once the tendon heals or the gut settles, there's no real reason to keep on going. And again, so that means, let's say you had a torn knee, use it to heal your torn knee. Everything is good. You're back to working out, you're back to doing what you need to do. There's no real reason to stay on it continuously after that because most of the tissue has been healed there, which again is pretty cool with peptides, is it's not something that we have to be dependent on if we do have an injury that we use to heal. Some of the standard cycling patterns I like four to eight weeks on, again, two to four weeks off. Usually, you know, somewhere in that line, 48 weeks on, two to four weeks off, you could do eight weeks on, eight weeks off. This is the most common pattern. Then you could do a targeted short cycle. If you wanted to do a single four to six week block for an acute thing. If you have a very chronic use case, you could obviously do up to 12 weeks, which means that I, I think that 12 weeks is, is malleable, meaning that sometimes you could do a little bit less, sometimes you could do a little bit more. And like I said earlier, I think when it comes to using this continuously, especially as for the case of an injury, I like going until that injury is near healed and then there's the option. And again, I'm not, I'm not saying this is the right thing to do, but you could do continuous low dose. So some longevity users run extended low doses. If you are going to do that, I would probably err on the side of the lower dose, meaning like 250 micrograms per do. So I would, I would stay lower if you're going to do it for a longer period of time. Again, just because we don't know what we don't know. Let's talk about the off cycle and long term considerations. What persists when you stop? Usually the structural gains are going to stay. A healed tendon obviously stays a heel tendon. And this is completely different from a compound whose effects depend on continued dosing. And again, active protection does not persist if you are buffering your gut against an irritant so that buffering stops when you stop. I always tell people this, for instance, like let's take gut health. Let's say that you are bombing your gut with pizza and beer every day. Could BPC help the damage that's coming from that? Of course it could. However, if you continue to bomb your gut with pizza and beer, BPC is only going to be able to do so much. Let's, let's take that to the athletic realm. Let's say you have tennis elbow because you're playing tennis all the time. I recently started playing tennis with Taylor and it's really fun. But let's say you have tennis elbow and you are chronically using your elbow in a way that causes inflammation. BPC can help it. But in a lot of cases, if you have repetitive use injuries, it's only going to do so much if you keep injuring it. And again, you can use it to heal. But be smart about how you do it and then also be smart with how you treat your body after that. Not saying it's not good to use, but again, if you become dependent on trying to use that in a lot of cases, I think that if the effects Diminish over time. In the case of like a tennis elbow, if you continue and continue and continue to injure the area through repetitive use. After a while, BPC is gonna kind of not work as well as probably it did the first time you do it. So again, just be smart. But we don't have a lot of human data when it comes to cycling and that's kind of my best practice around it. Let's talk about some other peptides because one, the cool thing about BPC is it pairs well with some other peptides. And I think when we talk about a comprehensive holistic approach to all this, I would be remiss if I didn't talk about other peptides. Obviously the best, the biggest one is The Wolverine stack. BPC and TB500. Why they, why they overlap? Both are foundational level. Foundational level repair tools hitting the problem from different angles. Obviously, BPC increases GH receptors on repair cells. TB500 keeps actin reserves at those cells needed to move and function. So the typical dosing, you could do it a couple different ways. I like a one to one dose. You could also do higher doses of TB 500. And so the, the one to one would be like 250 micrograms of each or 500 micrograms of each. Or if you had separate ones, you could do 2 to 5 milligrams per week of TB 500 and then 250 to 500 micrograms of BPC. So those pair really well with growth hormone peptides. I like starting with BPC157, you're gonna get some upregulation of the GH receptors. Then you could add in your growth hormone peptide, whether It's CJC and ipamorelin, tessamrelin, MK777, human growth hormone. Then we're going to get amplified GH pulses and then ultimately a stronger repair signal for our muscles and then also for injuries too, which works really well. When we talk about healing peptides. You can take those in the morning and then GH secretagogues usually are going to be before bed. You could do them in the morning too, but overall that's how you could use it. So you could do your BPC in the morning and then the secretogs or your growth hormone at night. And again, why is the reverse order of that suboptimal? If you run GH peptides alone first with no PPC 1, 7, you're sending growth hormone signals to tissue with fewer receptors to catch them and worse blood supply to deliver them. So does that mean that it's going to be bad? Of course not. But you're leaving a lot on the table if you're doing that, and especially if the goal is healing or optimal performance. And again, without BPC1v7, we have fewer GH receptors. With BPC we have more GH receptors, better vascularity, inflammation is more modulated, and GH signals land harder with amplified repair. Let's talk about reconstitution and injection because I think this is obviously, it's interesting to me that with my new AI tool, basically what that will do is it's obviously anonymized and aggregated data. So it's not looking at what people are actually typing in, but it is looking at the trends among the data. That's what's kind of cool with some of these large language models that we have. And what's interesting for me is the number one thing hands down is reconstitution and mixing. And people. I always forget because we have so many people coming into the peptide space, how important that is because obviously that's the first barrier to entry and most people are very scared of it. Again, that's why I'm covering this because I know for a lot of you guys it's basic, but something that I think is good for everyone to review. Most BPC comes in a 5 or a 10 milligram vial. I would just recommend 2 mls of water into that vial. If you have a 5 milligram vial and you add 2 mls of water, it's now 2.5 milligrams per milliliter, meaning that 10 units is 250 micrograms. If you have a 10 milligram vial, you had 2 mls, it's now 5 milligrams per milliliter. 10 units would be 500 micrograms. Again, that's the easiest thing to do with BPC. That slide right there. If you want to screenshot it, that's the easiest thing to do. 2mL water into your vial, take 10 units and you'll be good. Easy thing to do there. And again, I think for the, the most beginner friendly setup, this is the easiest thing to do. BPC is probably the most beginner friendly peptide for most people. And that is the easiest way to mix it. Obviously reconstitution, just prep it, draw the water, add gently when you're shooting it down the vial, don't, don't add it in all at one time or shoot it down really hard, let it dissolve and sit and then again Just wait for it to completely dissolve, then injection. I like to use a 29 to 31 gauge insulin syringe. Common sites are obviously for systemic use, going to be the abdomen, upper outer thigh, back of the upper arm. For a localized injury, I would inject sub Q to the injured area. Now what I mean by that and I'll try to show you. I don't know how well you'll be able to see it, but like for instance, what I like to do is just grab that skin like that and then slide the needle in there. So again, if you have your knee, you want to inject right on top of your knee because that's going to be pretty hard to do. You just pinch some skin and then slide it in sideways, inject into that and then let the skin go back down. And that's the easiest thing to do. You can kind of do it like a 45 to 90 degree angle slowly and then just rotate those sites. Even if it's an injury area, try to rotate the site so you're not getting too much tissue or scar tissue buildup, which you shouldn't with an insulin needle. But just to cover your bases, just kind of make sure you rotate it. And again, whether that's at the injury site or into your abdomen, then storage rules obviously just keep in the refrigerator and you should be good. The debate over whether it's good for 30 days. I've used BPC that's probably been seven or eight months old before and it was totally fine. But again, just be aware that there is some degradation of potency over time. Typically after like 30 to 60 days is when you'll see it start to fall off some. Now what do we track when we're looking at bpc? Obviously subjective markers, pain at rest, pain with movement, range of motion, bloating, digestion, sleep, energy, all those things. When we look at objective biomarkers, we can look at our metabolic panel or lipid panel. Fasting insulin, A1, C, H, S, C, R, P is really important for inflammation. And then also ferritin, vitamin D and our thyroid. Then performance metrics, HRV and resting heart rate via a fitness tracker like an aura ring you can do. And then for, for injury recovery you can look at grip strength, load tolerance on those movements. So again, know that's kind of simple. But just remember that when we're doing these things, we do want to measure the outcome, especially to make sure that we are getting our money's worth, but then also improving at the same time. We look at stacking, talked about TB500. I really like BPC and GHK. Basically, BPC is going to drive early prolifera phase and then GHK is going to support the later remodeling phase. And again, dosing for GHK I like around 1mg to 2mg start. You could go as high as 5mg if you wanted to. That's totally fine. I just usually don't feel the need to go that high. We obviously have kpv. I love love, love, love, love. I know I beat it like a dead horse, but KPV is so amazing. This one's gonna be a really good gut repair stack. BPC repairs the gut lining. KPV inhibits NF kappa B which is an inflammatory marker. And then both taken orally on an empty stomach will help with that. You could also inject both of them together in the same syringe. And I like 500 micrograms of each. And then obviously Thymos Alpha 1. I think a lot of people forget how powerful BPC and Thymosin Alpha 1 can get be together, especially for people with chronic issues that involve a lot of pain. Tissue repair plus immune support for chronic infections, autoimmune situations or or recovery where immune resilience matters. I think a lot of people fail to realize the importance of the immune system just in overall general recovery because obviously as we age, the thymus shrinks. And another great reason to use growth hormone or growth hormone peptide because we get some thymic tissue regrowth there. But I love BPC and thymos alpha one together for some of those more chronic autoimmune type conditions that are kind of weird things like that. We also obviously have the GH peptides. I just put CJC and I. But you could use Tess and MK777 human growth hormone. It's always gonna be synergistic with BPC. Doesn't mean that I stay on BPC all the time like I do my growth hormone, but there are times where I can use that to enhance the results for it. And again, we look at stacking. There are no famous hard no nos with bpc. It's usually a very friendly base compound that you can do with any other compound. But again, I like to just introduce one compound at a time. And so some people, if they've never done peptides before, they'll get the close stack, which can be fine. But I like working up to that where I know how I'm going to respond to each of those Peptides, so particularly the ghk. Whereas a lot of people can have a histamine or a swelling reaction from using the GHK and it becomes very painful. And again, just remember, if you're using blood thinners, make sure that you're not doing BPC at the same time with those. All right, let's get in some troubleshooting and some faq because I think this will help some people. Because what I do with these is I take all the questions I get asked and then extract the ones around bpc. And these are some of the more common ones. Obviously with any peptide a lot of people are like, hey, I feel nothing. It's the, the nothing works for me people. One, your bas, your baseline could be already good. So BPC is repair tool. If there's nothing meaning to repair, might not do too much. Again, for the instance of muscle growth, if you just take bpc, you're not gonna really grow muscle that much, might a little bit, but it's not gonna be like a growth hormone peptide or even hrt. Your dose could be too low. So again, just check your dose. And sometimes it's not even necessarily like knowing the dose, it's sometimes the reconstitution thing. And again, I talked to so many people that they don't really build the skill of knowing how to reconstitute and then the dose ends up being too low or unfortunately the, the worst thing sometimes is when it's too high. Not with bpc, but with some other peptides. Again, not enough times. Sometimes two weeks is just too often or too early to judge a tendon. Again, give at least four to eight weeks before you really draw conclusions. And even sometimes it's still not long enough there again, your product could be junk, which is again I think rarer than people think it is, but still a possibility. And again it might be a. It might not be a tissue repair problem. Maybe it's a mechanical issue that needs surgery, a structural tear or systemic condition driving symptoms. I'm not someone that tells you that BPC is always a replacement for surgery. In some cases it definitely is not. It can help with surgery, but in some cases you do need surgery. And also too sometimes when we look at inflammation, sometimes there's so much inflammation, something like KPV is necessary to help bring down the inflammation. Whereas BBC, we might not get enough anti inflammatory action out of it. Injection site reactions. I will say these are very rare, but I've still seen them. Might get redness, mild swelling, small bruise or temporary itching. Again just minimized by rotating sites. Usually it's if you do get it from bpc, it's from injecting in the same site too much. Some users. I will say this is something in surveying people that I've seen reporting fatigue, headaches, lightheadedness and mood changes. Like I mentioned before, it's usually a blood pressure thing because again BPC is modulating nitric oxide. Sometimes, especially if someone's on blood pressure medication or something to lower their blood pressure blood pressure, they might get a headache or lightheadedness because the blood pressure is too low. Which another thing you know, if you do have high blood pressure, BPC can be a really good peptide to use in the case of high blood pressure. Obviously just check on sourcing, make sure that's good and then when to discontinue if you have an infection at the injection site, obviously discontinue any significant unexplained symptoms or allergic reactions. Obviously stop if you have new bleeding or bruising issues, especially on a blood thinner. I would definitely stop obviously if you have upcoming surgery, I'm usually a fan, obviously talk with your doctor. I'm not a doctor, definitely not a surgeon, but I usually like to stop at least seven days before and then give it a few days after, three to seven days after before you resume. And then again if you are getting no benefit after a full, properly dosed, well sourced course, you have your answer. Obviously if it's not doing anything you, there's no need to keep going. Let's talk about some, some FAQs. Is BPC legal? Well, in January 2022 it was banned by WADA. Thank goodness for all the great people at WADA. Right, and that was a joke in, in case you were not paying attention. But WADA is obviously the governing body when it comes to drug testing for sports. And it's kind of funny that they ban these things that are just natural to the human body that I think every athlete would stand a benefit to gain. From September of 2023 the FDA placed BPC in category two, which basically mean that they advise compounding pharmacies to not make it because there was not enough safety data. And then here we are, fast forward February to April of 2026. The basically the FDA proposed to remove it from category two to make it eligible for reconsideration. But it's not yet Approved on the 503A bulks list. And obviously in July of this year, June is the time of me filming this is going to be on this review. I Think it's at the end of July that they're going to be reviewing it. So who know, who knows if it officially gets moved out of category two into category one. But we will see what happens. I do think if there is one that hap that has a good case for being removed, it's bpc. So just because it's, I mean it's really from a safety perspective, so safe. When you look at the some of the data, should you use BPC or TB500? Again, they're often used together, so usually the answer is use them both together. I will say BPC157 is going to have more of a localized effect, whereas TB500 is going to have more systemic effect. They can both do vice versa. So BPCs can still be systemic, TB500 can still be localized. But the distinction among them is that they typically are going to work a little bit differently in that sense. But I really like them together. Again, if the answer is, hey, I, I have this issue I want to use almost always going to be use them together. Oral versus injectable wet route. I'm not someone that is going to say that the oral is bad. It's just a very certain use case. Oral is viable because three PRO residues make BPC stable in stomach acid for 24 hours or plus again which is nearly unheard of. The oral is preferred for gut specific, specific issues like ulcers, ibs, IBD and leaky gut. And you want it acting directly on the gut lining. Obviously this means that you're gonna have lower systemic biobio availability than an injection. And then the injectable is gonna be preferred for localized injuries, tendons, lung, ligaments, soft tissue injuries. Obviously it delivers higher local concentration near the injury site, still distribute systemically regardless of the injection site. But it's gonna be better to inject in those injured areas cause you're gonna get more of an effect and obviously it has higher bioavailability. Again, we do have oral capsules, dissolvable strips and topical creams. I have used some topical creams that are out there in the research world and they are amazing so far and I really like those especially for some of those areas that are harder to inject. And also too if you have someone that is needle phobic, they can get exposure to those via the topical creams and it's amazing. So I really like those for dosing. Ah, let's take a second to talk about the cancer question because I think obviously bpc, one of the most popular peptides Obviously this is very big, it's very, it's a very trending thing to say for people that are from the, the mainstream ilk of influencers or content creators. Say that you're going to get cancer from BPC157. And again, why they say that I don't know. I don't know if someone's paying them say it or if they just like to say it to get views because it becomes very controversial. I don't really. I try to tamper away from doing very blatantly controversial type things because I like educating people, I don't like creating fights in the comments. But anyway, when we look at BBC it obviously promotes new blood vessel growth through VEGF related pathways. Tumors rely on exactly that kind of blood vessel growth to establish itself and grow. And again, this is a very plausible concern. Although we, we don't have a lot of data that shows that it plays out this way. When we look at it from a data perspective, the honest status that we don't know, it's a very plausible concern. It's unproven either way. I say the best practice, if you have acts of cancer, recent cancer history or elevated risk, discuss with your oncologist, be smart about how you use it. Maybe use some of those alternative peptides like a kpv, like a cardilax, like a thymus and alpha one like a PEG MGF that we know well, maybe not PEG MGF because it's upregulating localized igf. But anyway, we know that it's helping. We know those things are, are doing it in a way that BPC157 is not. And I feel more comfortable like if someone had an active tumor, a very recent active tumor, to do so. So again, use your own discretion. I can't tell you what to do. I know people that do it and they don't have issues. But who's to say down the down the road that that's not something, something that comes up. That's my ultimate verdict on it is if you're a very high risk person, probably stay away from it. But otherwise I don't lose sleep over this at all. I don't think it's one of those things. If you're healthy, you're doing everything metabolically healthy, you're living a healthy life, you're doing what you can. Not to say that you can't get cancer, but I worry zero, I lose zero sleep over BPC and cancer, especially in a relatively healthy person. What about anxiety, palpitations, insomnia, Some users report these and they often appear in enough anecdotal reports to mention a lot of times I think it's, it could be psychological because that does happen. I'm not saying it's every case, but it does happen that someone has a psychological reaction. Obviously the change in blood pressure can cause some of these things for people. And obviously there's the interaction with dopamine and serotonin that it definitely can affect people. And the longer I've been doing this, the more I am open minded and realize that that is a very plausible thing. And I never will say someone's crazy for telling me that because it can be very real. And how one thing affects someone's dopamine and serotonin can be completely different from the same compound and how it affects another person, which could be very beneficial in some cases. So that's kind of my thoughts around that. Trt, obviously we know no known interaction like we know BPC helps with growth hormone sensor sensitivity. We don't really know if it does with androgen receptor sensitivity. However, I like it alongside of it. So there's no known interaction gp1s I think it'd be great also people for the they're on GP1s that deal with gut side effects and use BPC for gut comfort. This can be very, very good to help. And again just if you're on blood blood thinners, I would not use it alongside blood thinners. Let's talk briefly about insets and alcohol. With inseads we don't see any dangerous interaction. BPC has actually shown protection against inset induced gut and liver damage in animals. However, insets blunt inflammation broadly and inflammation is a part of the early healing signal the BPC works with again, heavy chronic inside use. While trying to heal a tendon may work against your goal, I'm always very careful with those if you do have to use them very short time, very as needed basis. But obviously BPC is gonna be better with alcohol. There's no known dangerous interaction. It is actually shown to protect against alcohol induced gut and liver damage in animals. Again that doesn't make drinking on it a good idea. Alcohol undermines recovery, sleep and tissue repair. But if you are someone that is struggling with alcohol or struggling to repair your body from alcohol, BBC can be very beneficial. But I would definitely not say you can drink as much as you want to take bpc. That is definitely the wrong thing to do. When we look at animal safety data, there's no lethal dose identified, no mutagenicity, genotoxicity birth defects or anaphylactic potential from ppc. Again, doses in animals have been thousands of times higher than therapeutic range produced with no fatalities. And again, human safety, we do have strong animal safety data. There's not a lot of long term human evidence when we look at this. But from what I have seen, because I have seen a lot of data from people giving me anecdotal reports in humans, I don't see any issues other than maybe the lightheadedness, pregnant, pregnant, breastfeeding. I just avoid teenagers and children. I'm not going to sit here and tell you publicly to do it, but I do know people that do it. Again, you got to make your own decision, check with your doctor, do all those things. But the usual rule of thumb is to like, hey, only use it as needed. And then the cool thing now is we have some of these alternative delivery systems where you don't have to do injections. And then we look at nerve damage, neuropathy, Animal data is interesting for accelerated peripheral nerve regeneration and protective effects and spinal cord and brain injury models. Obviously we don't have human data, but I do think it's one of those things that could assist in that I really like pairing it with are290 for nerve damage or neuropathy. A lot of people would just use bpc. Sometimes it works, sometimes it doesn't. But usually if you pair it with are290, it works really well. To help with that, we look at leaky gut. One of the more coherent uses of VPC1,7 mechanistically is for leaky gut because again, it increases tight junction proteins z o 1 and occluding that seal the intestinal lining while calming gut inflammation. We also have cortisone shots. They actually do opposite, opposite things. Cortisone powerfully suppresses inflammation for fast pain relief, but can impair tendon healing with repeated use. Again, that's the the downside of cortisone shots. Whereas BPC modulates inflammation and actually supports repair, and in animal models it counteracted the healing impairment caused by corticosteroids. And again, if you do have to do the cortisone shots, at least use the BPC alongside of it. We look at drug testing, I don't really know, meaning that people ask me all the time, will I fail a drug test for bpc? To my knowledge, there's not anything that can test positive, but again there may be. And that's just what I what I think. But again, I'm not gonna tell you if you're if you're someone that gets drug tested that you can use BPC because there may be metabolites that can show up in the urine to look at it. And again if you are a drug tested athlete, just be aware if you get found using BPC you can get in trouble for that. But there's not any that I'm aware of that are able to test for. But that doesn't mean you you can't look at obviously pharma versus research grade. Just know what you're doing when it comes to that stuff. Obviously research is going to be much cheaper but it does seem like that we'll be able to access it pharmaceutically hopefully in the near future.
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Zootopia 2 has come home to Disney Plus.
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Hunter Williams
Let's go get ready for a new case.
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Hunter Williams
we're the greatest partners of all time. New friends you are Gary the snake and your last name Desnake. Dream team New habitats.
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Hunter Williams
You can watch the record breaking phenomenon at home. You're clearly working at Zootopia 2 now available on Disney Plus. Rated PG. Clinical trial history Did BBC ever fail a clinical trial? Not exactly. The development story is kind of mercury murky. We had a Croatian company run phase 1 and phase 2 trials for IBD and those were only ever reported as conference abstracts. The full repair, full peer reviewed data was never published. And again why that never happened we don't really know. But A separate phase one trial of oral BPC tablets registered in 2015 was later canceled with results withdrawn. So again did those get canceled because they weren't doing anything or it was just never funded? We don't really know. It's kind of hard to find out the stable and arginate variants. You will see marketing variants sometimes called BPC157 argonate salt or stable versions claiming better self stability or oral absorption than the standard acetate salt we don't really know. But it does seem that the originate salt version seem to be the better oral one and then the stable one would be better for injection. But again if in case you see that out there, looking at future outlook again what's changing? Obviously the regulatory environment is shifting and so it looks like more prescribers are going to be able to use this. I think we will probably see, assuming that the regulatory environment is friendly to it, we will probably see a boon in people using BPC157 and what that means for the broader economy, especially in healthcare. I don't know. Hopefully it means that more people have access and people have less surgeries and things like that. But again, that's a very big industry and sometimes the powers that be don't want that happening. So just be aware of that. Again, what's likely in the near term, hopefully we have some more, more small clinical pilots and case studies that come out in a clinical literature standpoint, more mechanistic work, continued heavy, real world off label use running well ahead. A formal evidence is probably what's gonna happen and to me that's okay. But again, are we gonna get a large rct? Probably not anytime soon because there's not a lot of incentive to do so. Again, just summing up, BPC works best as a foundation on doing all the things right, especially for the case of injury. Shines most when there is an actual tissue problem to repair. The fundamentals are in place and the product is sourced carefully and again, just get those things right and this is the best place to start learning what peptides can do for your body. I will say BPC is probably the easiest gateway peptide to get people into peptides because it's so mild from a side effect standpoint and usually the benefits kind of touch everyone out there. Regardless of wherever you're at, you're probably going to see some sort of benefit from BPC 157. Unless you are just an absolute pillar of health and nothing, nothing has ever been wrong with you. Which, you know, who's that? I know it's not, it's not me. So that is it for the slides and that is my masterclass on BPC157. Hopefully that was enjoyable. And hopefully even if you knew a lot about BPC157, maybe you picked up some, some things today that you didn't know that can be helpful for you going forward. Again, whether you're just researching on yourself, whether you're helping coach other people. But I love, I love bpc. Again, sometimes I think relative to some of the other peptides we have out there, I. One of my missions is to help get people exposed to some of these other peptides that might be underrated or just not enough people know about when it comes to peptides. A lot of people that know about peptides, usually if it's not a glp, BPC is one of the first ones that they talk about and say, hey, you gotta try bpc. I used it and I had all these good effects and I'm, I'm all for that. Like I said, I think it's an amazing gateway peptide to get people started on their peptide journey and kind of break them into peptides, introduce them, say hey, there's some really cool things going on here in the peptide space. Why don't you try this, even if it's just the oral version, to see how it helps some of the chronic issues that you may be having. Again, I wouldn't expect to heal injuries just using the oral one, but for someone that is a newbie to peptides and maybe scared of injecting, I think taking oral bpc, a lot of people will notice. Really good benefit from that. But that's it for this one. I would love to hear your thoughts and feedback. It seems like a lot of the feedback on the Masterclass is that people really like them. I know it's not the short 2 minute, 3 minute video of fast food type content, but that's okay. I really love doing these deep dives and trying to cover every nuance that comes up with the peptide. Just so you kind of know from a practical implementation and application standpoint how you would you use this. And again, whether it's for yourself or other people that you're helping, that you have a really good framework for understanding that. So looking forward to your feedback on this one. As always, make sure on the email list check out all that. And just in closing, thank you guys so much. Whatever shape, form or fashion it is that you support me that goes so far in helping me bring these messages to you. So I have so much gratitude in my heart. Again, whether that's using my coded places, sharing this with friends and family, being in the private group, being on the email list, liking coming, subscribing, any of that stuff helps so much me, helps me so much bring these messages to you and I appreciate that so much more than you know. So that's it for this one and I will talk to you in the next one. Peace.