Podcast
The Hunter Williams Podcast
Hosted by Hunter Williams · EN
Average health is a choice. And it's the wrong one.
The Hunter Williams Podcast goes where mainstream medicine won't — deep into the science of peptides, hormone optimization, metabolic health, and biohacking protocols that actually move the needle.
Every week, I sit down with elite researchers, doctors, and high-performers to cut through the noise and hand you biological leverage most people will never have access to.
This isn't wellness. This is optimization.
Subscribe. Take control of your biology.
30episodes
Episodes
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Reader Mailbag 4 — Peptide Overdoses, GLP-1 Anhedonia & Hormone Truths
3d ago01:11:08Tap to summarizeTaylor and I are back for another Reader Mailbag. This one covers a lot of ground.We start with anhedonia on GLP-1s because the questions on this have been nonstop. People are experiencing it on Semaglutide, Tirzepatide, and Retatrutide and we break down why it happens, whether it is dose related, and what you can actually do about it.From there we get into the Reta and heart rate debate, Taylor's GLP rotation strategy, and whether the cardiovascular tradeoffs are actually worth worrying about.Then Taylor takes over for the hormone optimization section for young women in their twenties and thirties. Her personal story on this one is worth watching alone.We also cover accidental peptide overdoses, what to do when it happens, and finish with teen acne solutions using peptides and topicals.Submit your questions for the next episode at the link below.For research and entertainment purposes only.Links, cheatsheet, private group and more 👇https://hunterwilliamshealth.com/links
Transcribe →The May 2026 Q&A | Retatrutide, Testosterone, Autoimmune, and Beyond
1w ago00:59:01Tap to summarizeHey everybody, this is the May 2026 Q&A video, and we made it through a packed hour of your questions. I had so many submitted that I had to print them off and group them by category to get through them all.All My Links Here: https://hunterwilliamshealth.com/linksWe cover a lot of ground. GLPs and fertility, hunger on retatrutide, dopamine differences between Sema, Tirz, and Retta, GLP side effects and how to manage them. Then we move into hormones and HRT, including the right starting dose of testosterone, kisspeptin for fertility, progesterone dosing for women, and why so many doctors are starting guys way too low.From there we get into GH peptides and IGF cycling, my full injury healing stack, autoimmune protocols, cognitive stacks for studying, cosmetic questions, heart health, bone density, thyroid, and a long miscellaneous section covering rapamycin, MOTS-c, prostate peptides, traveling with peptides, and more.I also share the new AI chat tool I built that is trained only on my content. It is at chat.hunterwilliamshealth.com if you want to play with it.Thanks for submitting these. Keep them coming. See you in June.⚠️ For research and entertainment purposes only. ⚠️
Transcribe →The SS-31 Masterclass | Dosing, Stacking, Cycling, and Why It's A Top 3 Peptide
1w ago00:42:11Tap to summarizeAll links here: https://hunterwilliamshealth.com/linksSS-31 continues to be one of my favorite peptides of all time, and the more data that comes out on it, the more I think every person over 25 has a use case for it.In this masterclass, I'm breaking down everything I know about SS-31. We cover what it actually does at the cellular level, why it's the first FDA-approved mitochondrial peptide, and why it works differently than almost every other peptide out there. No receptor binding. It goes inside your cells, binds to cardiolipin, and stabilizes the structure of your mitochondria.I walk through the three dosing tiers I use with people, my take on cycling, why I run SS-31 before MOTS-c, how to stack it with GLPs, GH peptides, and the healing peptides, and what to actually track when you're on it. I also cover the troubleshooting stuff people ask me about constantly. Why don't I feel anything? Should I cycle? What about the headaches in the first two weeks?If you're a clinician or just researching for yourself, this is the complete user's guide.For entertainment purposes only.Timestamps00:00 Intro01:00 What this masterclass covers03:18 Why SS-31 matters and what makes it different03:46 FDA approval and the Forzenity brand name04:50 Peptide foundations and how SS-31 is made05:52 The SS-31 sequence and the Seto-Schiller naming origin06:40 Mitochondria 101 and why ATP matters07:28 Mitochondrial dysfunction across chronic disease08:34 Cardiolipin, cristae, and Barth syndrome09:34 Why SS-31 is not a direct antioxidant10:46 How SS-31 actually works (the upstream Godfather effect)11:12 Why no receptor means no desensitization13:36 Who SS-31 is for (mid-30s, athletes, post-illness, metabolic dysfunction)14:24 Who should skip it15:34 The three-tier dosing ladder16:54 The FDA-approved 40mg dose and diminishing returns19:08 Dosing by goal (longevity, performance, recovery, healing)19:48 Cycling logic and the 8-12 week framework20:22 When to dose (morning vs night)21:24 What to expect and when (week-by-week timeline)22:20 Why cycle if it doesn't desensitize24:24 SS-31 before MOTS-c (the structural engineer vs operations manager)26:18 Reconstitution and injection technique28:22 What to track (subjective markers and biomarkers)29:18 Stacking with MOTS-c, Humanin, BPC, GH peptides, and GLPs31:28 Stacking for cognition and visceral fat32:26 Troubleshooting "I don't feel anything"33:54 Injection site reactions34:36 When to discontinue and the first-two-week headache window35:52 FAQ (legality, MitoQ comparison, oral routes, intranasal)36:54 Use cases (weight loss, long COVID, athletic performance, TRT, kids)37:54 Research grade vs pharmaceutical cost difference38:22 Future outlook (AMD, sarcopenia, SBT-272, oral bioavailability)40:30 Final thoughts and where SS-31 sits in the broader picture42:20 Closing
Transcribe →Peptides and Cancer | 20+ Studies the Critics Won't Show You
2w ago00:30:08Tap to summarizeAll links here: https://hunterwilliamshealth.com/linksTimestamps:00:00 Intro01:00 Why I'm making this video04:00 The plan: peptides with direct anti-cancer evidence06:02 AOD-9604 and HGH Frag 176-19107:42 BPC-15709:54 DSIP (Delta Sleep Inducing Peptide)11:08 Epitalon12:30 Follistatin 34413:30 GHK-Cu14:36 Kisspeptin15:58 KPV17:18 LL-3718:46 Melanotan 219:58 MOTS-c21:12 Retatrutide22:34 Semaglutide23:40 SS-3124:38 Thymalin25:26 Thymosin Alpha-127:00 Tirzepatide27:30 VIP (Vasoactive Intestinal Peptide)28:06 Bottom line and closing thoughtsDescriptionIf you spend any time in the peptide social media world, you've heard it. "Peptides cause cancer." It's the easiest way to scare someone off something, and a lot of people do it without ever showing you a single study.So I went and pulled the studies. In this video I walk through every peptide on the popular research peptide list that actually has direct anti-cancer evidence in the published literature. Not theory. Not mechanism guesses. Actual studies in cells, animals, and in some cases, humans.You'll see what the research says about BPC-157, GHK-Cu, Epitalon, KPV, LL-37, Thymosin Alpha-1, MOTS-c, semaglutide, tirzepatide, retatrutide, and a handful more. Some of this evidence is strong. Some is preliminary. I'm honest about both.This is not medical advice and I'm not telling you peptides cure cancer. That's not what the data says and that's not what I'm claiming. What I am saying is that the next time someone hits you with a 60 second clip telling you peptides cause cancer, you'll have something more substantial to weigh it against.All study links below.📚 Studies Referenced (in order of appearance)AOD-9604 / HGH Frag 176-191 https://pmc.ncbi.nlm.nih.gov/articles/PMC9249349/BPC-157 https://journals.lww.com/melanomaresearch/citation/2004/08000/bpc_157_inhibits_cell_growth_and_vegf_signalling.50.aspx https://pubmed.ncbi.nlm.nih.gov/29886825/DSIPhttps://pubmed.ncbi.nlm.nih.gov/12782416/Epitalon https://pubmed.ncbi.nlm.nih.gov/14501183/ https://pubmed.ncbi.nlm.nih.gov/12209581/ https://pubmed.ncbi.nlm.nih.gov/12049808/Follistatin 344 https://pmc.ncbi.nlm.nih.gov/articles/PMC9633376/GHK-Cu https://neoplasiaresearch.com/index.php/jao/article/view/217 https://www.lidsen.com/journals/genetics/genetics-05-02-128Kisspeptin https://pubmed.ncbi.nlm.nih.gov/8944003/ https://pubmed.ncbi.nlm.nih.gov/28944853/KPV https://pmc.ncbi.nlm.nih.gov/articles/PMC4957955/LL-37 https://pmc.ncbi.nlm.nih.gov/articles/PMC3910284/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3659029/Melanotan 2 https://pmc.ncbi.nlm.nih.gov/articles/PMC7013727/MOTS-c https://pmc.ncbi.nlm.nih.gov/articles/PMC11578304/Retatrutide https://pmc.ncbi.nlm.nih.gov/articles/PMC11908972/Semaglutide https://pmc.ncbi.nlm.nih.gov/articles/PMC11227080/ https://pubmed.ncbi.nlm.nih.gov/38683947/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12587238/SS-31 https://pmc.ncbi.nlm.nih.gov/articles/PMC7923037/Thymalin https://pubmed.ncbi.nlm.nih.gov/6752596/ https://pubmed.ncbi.nlm.nih.gov/29797130/Thymosin Alpha-1 https://pubmed.ncbi.nlm.nih.gov/8652276/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2748379/ https://pubmed.ncbi.nlm.nih.gov/20194853/ https://pubmed.ncbi.nlm.nih.gov/27900029/ https://pubmed.ncbi.nlm.nih.gov/30063847/Tirzepatide https://www.biorxiv.org/content/10.1101/2024.01.20.576484v1 https://aacrjournals.org/cancerres/article/84/6_Supplement/2188/738498/Abstract-2188-Tirzepatide-treatment-restoresVIPhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6317926/
Transcribe →Retatrutide Masterclass | Dosing, Side Effects, and the Framework Most People Get Wrong
2w ago00:51:20Tap to summarizeAll links here: https://hunterwilliamshealth.com/links00:00 — Intro and why I'm doing these masterclasses02:42 — What we're covering and the regulatory timeline04:04 — The two users: weight loss vs longevity05:30 — What Retatrutide actually does (the three receptors)06:50 — Why the glucagon receptor makes Retatrutide different07:54 — Weight loss trial data (1mg to 12mg)10:50 — The longevity data: liver fat, ApoB, blood pressure13:14 — Who the lean biohacker user is13:50 — The titration playbook15:32 — Once weekly vs split dosing19:50 — Morning vs night injections21:02 — How far to push the dose (why 8mg is the ceiling)22:50 — How long to stay on and the regain problem25:44 — Longevity maintenance protocol26:34 — Lean user protocol27:24 — Protein and training are non-negotiable29:06 — Side effects and how to manage them30:20 — The heart rate question and why I use taurine32:00 — The weird skin sensitivity issue33:48 — Pairing Retatrutide with testosterone35:56 — Drug interactions (blood pressure, thyroid, insulin)37:02 — Metrics that matter38:42 — How to cycle off correctly39:54 — The most common mistakes40:42 — How to start, what to do if you plateau43:04 — Should you switch from Tirzepatide?45:28 — Combining Retatrutide with other peptides46:50 — The Ten Commandments of Retatrutide use47:50 — The bottom lineToday's episode is the first in a new format I'm rolling out. I'm working on a book where I cover one peptide at a time, one chapter at a time. Alongside that, I wanted to do a masterclass on each peptide and condense down everything I know into one place. First up is Retatrutide.I cover what it actually does in your body, the two very different users that should be on it, and the dosing strategies that get debated to death online. We go through the weight loss data, the longevity data, and why I think 8 milligrams is the real ceiling for most people. I also break down once weekly versus split dosing, the heart rate question, the skin sensitivity issue, and why testosterone optimization has to come first.If you want a definitive guide on Retatrutide, this is it. My goal is that you walk away with a framework you can actually use, whether it's on yourself, your coaching clients, or your patients.Let me know what you think. I plan on doing many more of these on every peptide that matters.⚠️ For research and entertainment purposes only. ⚠️
Transcribe →Saturday Morning Coffee Talk 5/16/26
3w ago01:58:36Tap to summarizeAll Links Here: https://hunterwilliamshealth.com/links
Transcribe →Episode 4 — Why the 49ers Can't Stay Healthy | Peter Cowan on EMF, Substations, and Your Hormones
3w ago01:05:36Tap to summarizeIf you do everything right and still feel off, this episode is for you.I sat down with Peter Cowan, a quantum biology practitioner and environmental health investigator who got chronically sick from EMF exposure, walked away from Silicon Valley, and spent years figuring out why on his own. Peter's Substack series on the San Francisco 49ers, who practice and play right next to a power substation, is some of the most compelling EMF research I've seen anywhere.We covered the EMF checklist anyone can run at home, the mitochondrial mechanism behind oxidative stress from magnetic fields, how EMF disrupts the cortisol and melatonin cycle that drives your testosterone, why pre-sunrise workouts under fluorescent lights are doing more damage than most people realize, and the three-pronged light protocol that took Peter's testosterone from 437 to over 800.Follow Peter: https://peteranthonycowan.substack.com/For research and entertainment purposes only.👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/links
Transcribe →This Peptide Works 10X Faster Than SSRIs (Here's How)
3w ago00:16:39Tap to summarize👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/linksPE-22-28 is one of those peptides almost nobody is talking about, and I think that's a shame. In this episode I walk you through what it is, how it works, and why I'd put it in the antidepressant category before I'd call it a true nootropic.I get into the background as an optimized analogue of spadin, the TREK-1 channel inhibition that drives the effect, and the downstream impact on BDNF, synaptogenesis, and neuroinflammation. I also cover the part most people care about: the rapid antidepressant onset, usually around four days, versus the three to four weeks you wait on a typical SSRI.From there I share the dosing protocol I've been using on myself, including a four-on, three-off cycle to keep tolerance low, plus what I've noticed in terms of mood, mental energy, and the lack of any real come-down or withdrawal.I'm not saying this is a cure for depression. Depression is multifaceted and deserves a multifaceted approach. But if you need something to help get you out of the hole and back into the habits that actually move the needle, PE-22-28 is worth knowing about.
Transcribe →Reader Mailbag 3 — Traveling, Glutathione, Sleep & More | Hunter & Taylor Williams
4w ago01:07:11Tap to summarizeHunter and Taylor are back for another deep dive Reader Mailbag. Real questions, real answers, no shortcuts.This week: traveling with peptides and TRT through customs, fixing glutathione injection pain, melanatan 1 vs 2 and skin cancer risk, severe female insomnia and perimenopause sleep protocols, retatrutide plateaus and GLP-1 desensitization, and how to actually build a peptide stack using the bleeding neck framework.Whether you're new to peptides or deep in your optimization journey this one has something for everyone.Submit your questions for the next episode at the link below.For research and entertainment purposes only.👇 EVERYTHING IN ONE PLACEhttps://hunterwilliamshealth.com/links
Transcribe →20 Fat Loss Compounds Ranked Worst to Best (No GLP-1s)
May 500:46:32Tap to summarize👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/linksGLP-1s like retatrutide are the kings of fat loss. No argument there. But what do you actually do when you're cycling off, when GLP-1s aren't on the table, or when you want to stack something alongside your GLP-1 so you don't have to escalate the dose?In this video I rank 20 non-GLP-1 fat loss compounds from F-tier to S-tier. Most are peptides. A few are small molecules. Some I use all the time. Some I would never touch.I cover the mechanisms, the dosing protocols I actually run, the side effects I've personally experienced, and where each one fits in a real fat loss program. You'll get my honest take on adipotide, AOD-9604, sermorelin, setmelanotide, tesofensine, SS-31, cagrilintide, IGF-1 LR3, cardarine, CJC/ipamorelin, MOTS-c, 5-amino-1MQ, BAM15, SLU-PP-332, ATX-304, mirabegron, albuterol, HGH, and tesamorelin.Hormones and lifestyle come first. Always. But once those are dialed in, these are the tools worth knowing about.If you want my peptide cheat sheet and links to everything I use, check the description below. And if you want to ask me questions directly, come hang out in the Axion Collective.
Transcribe →