← The Hunter Williams Podcast
The Hunter Williams Podcast
DSIP Masterclass | A Researcher’s Guide to the Sleep Peptide (2026)
00:38:01
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Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today is going to be the D SIP masterclass. I'm really excited for this one. I think if you look at the statistics around sleep, there is probably as many people that struggle with sleep these days as do obesity or being overweight. And so when we look at lifestyle issues, I think sleep is one of the biggest ones that people struggle with. And the thing that's tough about sleep is I think a lot of people that do everything else healthy can still end up struggling with sleep. So I don't think DCEP is a panacea or a cure all when it comes to sleep. However, there are many benefits of dcep. And I will say I think DCEP is probably underutilized. And I think the reason that's underutilized is people go, don't really understand what it's doing. And I think I'll probably reference this multiple times throughout the presentation today. I think it's more or less that people are looking for a peptide version of Ambien to just knock them out. They want to not be able to wind down before bed. They kind of want to like go, go, go and be able to take a peptide and have it knock em out and then wake up in the morning and be ready to go. And unfortunately, to my knowledge, there's not anything that can really do that in a healthy way. However, DIP is very useful and the, the ironic thing about it is it actually didn't come out of sleep research. It actually came out of opioid and alcohol withdrawal research. And then we ended up finding that it can have positive benefits on sleep architecture. So sleep is just one of the benefits that comes out of decep and there are many other things that it does that we will talk about today. But I'm excited because I think people, they use DCIP and they don't get the results that they're expecting and they kind of write it off. But today, hopefully we can revisit it, whether you're a veteran user or a news user, to really understand what it's doing so that we can actually harness it in a way that is potentially beneficial for our lives. And I say that not saying that D SIP is a worthless peptide, I think it's just a misused peptide. And if people were to use it the right way and stack it with the right things, it would actually be much more beneficial. So we're gonna cover all that today. But before I jump into the slides, as always, thank you so much for being here. The feedback on the Masterclass has been amazing. There's been a lot of people that said these have been very helpful so I will continue to make them and just kind of go down my checklist of peptides that I'm working on. But always make sure you're on the email list. It seems like lately there's actually been a wave of censorship. Fortunately for me, all my stuff is still up. But I have talked to multiple other influencers that have gotten their YouTube accounts and Instagram Instagram accounts deleted recently, which is a travesty. But hey, that's the world we live in. And so please just make sure on the email list I do not say that to try to spam you or sell you anything, just to make sure that you're in contact with me if something were to happen again with my channels, to make sure that you're in touch with me if you want to be in touch with me. And then also too make sure make sure you check out the Axion Collective that is growing. We have an amazing group there. We do live coaching calls every Thursday night at 8pm Eastern and there's tons and tons of content there that's not available publicly that you could even even if you just wanted to join and binge watch. There's probably over 40 to 50 hours of masterclass esque content in there that are not topics that I talk about on YouTube and then obviously too if you want to check out my AI chat tool, you can check that out at chat.hunter williamshealth.com it's pretty cool. Again, that's not to compete with Chat, GPT or Grok or anything like that. Basically it's just a chat function. You can search the database of my content and actually interact with it and chat with it and got really good feedback on that so far. Seems to be like there's a lot of people on there using it and so it seems to be going well. But without further ado, I'm going to share my screen and today we are going to cover dip. Okay, let's get into it. Today is going to be dip, the Complete User's Guide. I want this to be a practical masterclass on sleep architecture and neuroendocrine modulation. That sounds like a mouthful. It sounds really fancy. It's not. I promise we'll cover that today. But rather than thinking of DIP as Ambien or something to knock you out, really think about it as the context of sleep architecture and neuroendocrine modulation. And when you understand it from that context, it actually will make much more sense and hopefully you'll be able to get better results out of it. Now let's talk about what DIP is and what it isn't. One, it is not a sedative, it is not ambient. I want to be very clear about that because again, I think when people look at peptides, obviously they're looking at them to become healthier and just make their lives better, right? And we look at dip, it can absolutely do that. But it's not something that you can just run yourself ragged and then think that you're gonna take a peptide and that it's gonna fix all of your sleep problems. It stands for delta sleep inducing peptide. It is a nine amino acid chain that our brain appears to produce naturally. It's been studied for nearly 50 years. And I said it because it's, it's one of the more, less understood peptides out there. What it does is it normalizes sleep architecture over consecutive nights and dampens our stress axis without grogginess, rebound or dependence. And, and that's, I think what is important to understand is that it dampens our stress access and dampens the stress response that we're having that a lot of times can end up causing sleep issues for most people. Let's look at the discovery story because I think in my opinion as a history buff and nerd, it's pretty cool. In the early 60s, a guy named Marcel Monier at the University of Basel connected the blood supply of two rabbits. And when he stimulated deep sleep in the first, something crossed the blood and produced deep sleep in a second, proving sleep was carried by a chemical signal. Then Monier and biochemist Guido Schonenberger purified that signal, worked out its structure and published the synthetic version in around 1990 or 1977 and 1978. Then DISA became one of the first sleep substances chemically defined and one of the first peptides shown to cross into the brain intact after injection. Thus, it appears to successfully cross the blood brain barrier and then carry out all the effects that we actually want to get. Now, here's what we don't know about it so far, which is unresolved. We don't know if there's a receptor, meaning that 50 years of research, of searching has not found a specific DIP receptor, whether it's in the brain or the body, a gene for DIP or a precursor protein. However, DIP acts as a modulator by touching several systems at once through low strength interactions, nudging things back towards their set point. And then we also see a bell shaped curb. So a moderate dose can work better than a high one. And, and this shapes everything about how we're going to use it. And I think there's a sweet spot. I think probably we'll talk about this in the dosing section. I think probably if the, if the lower end of the dosing is what's recommended out there and people don't get the benefits, but then going high can actually, I've seen actually potentially cause people to sleep worse and actually be too energized. And again, we'll cover that in the dosing section when we look at sleep architecture and sleep systems. I by no means am an expert on sleep depending on, but I know enough as it relates to peptides to kind of walk you through this one. Let's talk about sleep architecture. We have basically light sleep, deep slow wave sleep, and then REM or REM sleep several times a night. Good sleep is usually about moving through these stages in the right proportions and the structure that encompasses all those is what we call sleep architecture. And again, I've got actually this new ring called a ringcon R I N G C O N N and I've been trying this out. In contrast to the OURA ring, it seems to work pretty well. So far it's very similar to the OURA ring. But point being is that now that we have devices that can track this and actually give us insight into what's working and what's not working. And then also on the other side of the sleep system we have the HPA stress axis which basically involves the hypothalamus, the pituitary, the adrenal glands and ultimately cortisol. And when this chain runs hot too long, you get the wire but tired state that wrecks our sleep. And, and again D can be used to turn down the volume on this chain, ultimately meaning that it can act as a modulator of cortisol, which will improve our sleep architecture. And again, just to sum up with that little diagram, we have light, light sleep that leads to deep slow wave sleep, which is where we get physical restoration. Then that leads to REM sleep where we see our dreaming. And then this cycle repeats multiple times per night. And the more that we can enhance the cycle, usually the better our sleep will be or which in turn will lead to us having much better lives. I know for me personally if I get seven hours of sleep, I feel great. If I get five hours sleep, I turn into a different person and my personality actually becomes very different than who it is when I have seven hours of sleep. And again, I think when we talk about optimizing this when we want to live a healthy, more abundant, more prosperous life, the better we can sleep. However long it ends up being, it's going to result in a life that we probably think is better. When we look at the mechanisms of what DIP does, one, we have this, this acne on GABA and glutamate. Basically it strengthens a GABA signal and it also quiets excitatory glutamate, which is the same general profile as anesthesia and anesthetics. DIP also acts as a natural painkiller. So it triggers the release of endorphins and in caliphins, which is why it appears in withdrawal and pain literature. Again, I think. Is someone that is in chronic pain going to experience this miraculous painkiller effect from bip? No. However, it does contribute to that. It does release some of these endorphins and caliphins, which can be beneficial, especially if you're pairing it with something like a Met and Caliphin or like even a low dose naltrexone that enhances that and you could potentially get a synergistic effect from those things. It also works on hormones as well. So it suppresses catabolic stress hormones while supporting anabolic hormones like growth hormone. Fun fact. We'll talk about this a little bit, but just to tease you a little bit to stay through the presentation, DIP actually can increase natural growth hormone production, which is pretty cool. We also see mitochondrial protection that protects the cells mitochondria under stress and also crosses the blood brain barrier without saturating. So pretty cool there that we see some mitochondrial protection. Why is it unique? One it's more of this modulator. So when we look at peptides, I like to say there's peptides that are kind of a hammer. So a GOP one can be a hammer. The more you increase the dose, the more of a chemical signal is going to be affected onto the body that is then going to have an intended reaction. However, we have also these peptides that act more as modulators or normalizers. For instance, Thymus Alpha 1, I recently did the masterclass on that. That's more of a modulator. So the more and more thymen alpha one you take, you probably are not going to notice any benefit because it's only going to modulate to a point and then it's going to stop exerting the effect. DIP is much more that way. I did mention that you can potentially take too much to where it's stimulating. But even beyond a certain point, the difference between 10 milligrams and 100 milligrams of Decep supplementing, which would be a very, very hefty dose, you're not gonna notice that much more of effect, meaning that you're not gonna be sedated that much more or even energized that much more. But what it does do is it restores the pattern of sleep. And again, when we use it, we don't get any daytime sedation. Typically people report no grogginess, in some cases actually even improve daytime alertness. Also, it doesn't seem to have a tolerance built over weeks of use in the published human trials, which is pretty cool. And then there doesn't seem to be a rebound, meaning that when we come off of D sip, unlike other sleeping medications that are pharmaceutical in nature, we don't see a withdrawal rebound insomnia when people stop, which is pretty rare to see. When we look at sleep medications, however, that's what make peptides so cool. Now who is a good candidate for dip? I think anyone that sleeps, which is obviously everyone, could be a good candidate. But let's talk about like kind of the use cases of where it does well. One, we have the disrupted rhythm traveler. People that have flights that are going across different time zones and late work nights. It can actually work as a circadian rhythm modulator to kind of bring your circadian rhythm back to what would be most natural to you. I know some people are more morning people, some people are more late night people. And dip can kind of restore whatever is your more natural circadian rhythm. We also have the wired but tired high performer. That's probably a lot of you guys, myself included, that have a stress, stress axis that won't shut off at night. Guilty as charged right here, myself. And that might be you too. But dips, HPA dampening targets. Exactly this stress access, which can help modulate some of the cortisol, which can end up resulting in better, more restorative sleep. Also, people that are chronic insomniacs, I know that's something that some people just have struggled with their whole life from the time of being a child, Whether it's like narcolepsy or insomnia. And repeated, normal, repeated dosing typically normalizes within one to two weeks for most people. And then we just have the recovery and longevity user and these people, probably you as well, looking at long term inputs to improve health. And I think when we look at decep, this is actually one of Those again quote unquote sleep peptide. But actually I think cyclically speaking could be a geroprotective or longevity agent because of what it's doing as an antioxidant as mitochondrial production and probably even some beyond the stuff that we actually even understand of what's doing benefit that's beneficial in nature. Who should skip it 1 I I don't know that everyone should necessarily anyone that should necessarily skip it. However, if you're not carrying out proper sleep hygiene I don't know that D SIP is going to fix that. I can say that in my own life and it hasn't when I have not had proper sleep hygiene due to stress or work or whatever it is. It's not something that D SIP will overcome. Sure. Can it assist? Absolutely. But it's not going to fit the fact Fix the fact if you drink caffeine after 4pm if you sit in your bed and scroll your phone or have blue light bombing your eyes in bed and you don't exercise and you're not getting sunlight in the morning and you're not doing the things that we know drive upstream circadian regulation dip cannot necessarily fix those things. No amount of dip is going to replace the fact that you're not getting sunlight in the morning or you're bombing your eyes with blue light in bed. And again sleep hygiene sits upstream of every sleep tool. And also too if and I think this is the most common thing is people have wrong expectations. If you want a knockout sedative this is the not the wrong molecule. I actually you'll probably get more of a sedative effect from things like growth hormone or tesrellin than you would even decep. Again this is much more of a sleep architecture modulator than it is a Ambien supplement. And again it just extends what a working system can do. It does not rescue a broken one. Some contraindications and cautions very few but pregnancy and breastfeeding obviously just avoid cause we don't have data children and teens, we don't have any sort of data around that. I'm not saying you can't give it to children and teens, we just don't have any ones and when we talk about hormone systems I just always want to be a little bit more careful with that. And then people on central nervous system modulation so no formal drug interaction testing exists but again just start low and go slow if you are using other things that modulate your nervous system. And again I don't say this to be dangerous. Most peptides are Very, very safe. But it's just we don't know what we don't know. Let's talk about the dosing. I kind of think of this as with most peptides in three dosing tiers. The, the general tier. And this is where most people, if they go online, you're going to see stuff, they start in this 100, 200 microgram range. I think that can be great if you are just starting out there or if you want something to calm you down and reduce stress. However, at those doses, I have seen very little sleep architecture modulation. At least it relates to my own data on my ordering. However, when I move up to the tier 2 dose, which is, I was gonna say most people are going to see some sort of therapeutic effect that is practical in nature. To me, that's the 500 micrograms to 1 milligram dose. And I think this is where most people will say, okay, yeah, I'm actually feeling something going on here. Whereas in my experience, people at the 100 to 250 micrograms, I just don't really see anything going on there practically or anecdotally. And again, then we would go to tier three, which would be significant. And I think this is going to be much more like if you were in the withdrawal camp and you're working on opioid alcohol withdrawal. This is where it's been clinically studied to do intravenously and where they're doing multiple milligrams at a time. And I wouldn't recommend that for everyone. Obviously that needs to be under medical supervision if you're doing intravenous. But that would be the significant amount. And I didn't put a specific milligram amount there because again, you get into the tens and hundreds of milligrams. That's something that needs to be under medical supervision. I will say for most people, 500 micrograms or 1 milligram seems to be the really sweet spot. I don't know that you benefit anymore to go to like 3 milligrams or 5 milligrams. I don't think that would be dangerous. And so you gotta do you and figure out what works best for you. But for most people, that threshold dose seems to be 500 micrograms to 1 milligram. When we look at dosing by purpose sleep architecture, I like that. 500 micrograms to 1 milligram, 30 to 60 minutes before bed and then run that nightly for 7 to 10 days for a cumulative effect. I think for a lot of people, if you don't have sleep issues, but you're just trying to improve everything. That's a, a good place for circadian rhythm and people that are traveling. Same dosing, 500 mic to 1mg but just use situationally around travel. And this is kind of my personal favorite application. Stress and HPA axis. Again, this is where that lower dose could be beneficial. If you don't necessarily need improvement in sleep, you want to save money, you could just do that lower dose again 30 to 60 minutes before bed. Also too potentially before an anticipated stressor, maybe you have something coming up that you would be stressed about with work or whatever. It could be very good as a prophylactic leaking leading into that to kind of calm your nervous system down. Because we all can let the monkey mind run wild sometimes. And dip can potentially be a good thing. It's not like a Xanax or anything like that, but it can potentially be a good thing. And I don't condone the use of Xanax. That's not something I personally use. But I do do know people do that for things to kind of chill them out. We look at as a zero protective. All that means is a longevity agent. This is much modeled on the Russian Deltaran longevity work around 500 micrograms on a five day per month cycle. And so if you just wanna do one week outta the month, Monday through Friday, you could do 500 micrograms. And again this would be more of a longevity protocol to act as an antioxidant, not something that you would necessarily say is going to change or really alter the sleep architecture that much. When we look at timing in the half life, DIP has about a 30 minute half life in the blood. The reason that matters is because if we dose too early and the peak fades before sleep, we don't get the, the benefits. And if we dose too late, the peak lands after already down. And what I have noticed practically spe speaking is that the timing for DIP can be different for everyone. So some people do better if they do it like three hours before bed. I personally find that like 60 minutes or 30 minutes before bed is the, the sweet spot for me. I will say it's completely different. But a good rule of thumb is like whenever you do well taking melatonin, that's a good rule to say okay, then dip will probably work for me at that time. Meaning that if you take melatonin immediately before bed, actually sometimes it doesn't work or it can make you groggy in the morning. So if you take it 30 to 60 minutes before bed. It actually times up to like where you're hitting that sleep rhythm to where it's maximizing its efficacy. And then sometimes some people need it like three hours before bed because that's how they kind of work and metabolize things. Just really depends on how things go. For you. A good rule of thumb is 30 to 60 minutes before bed. For me, that's personally what I do and seems to work the best. In human trials, there was actually slightly arousing effect in the first hour, which again, give yourself that 60 minutes to let your body kind of acclimate to it, metabolize it, break down, and then have the effects. And the benefit is better sleep that reveals itself as the night goes on and as the night times up. And this is one of those things. It's not gonna be like a one night thing. It really needs a cumulative effect of at least one to two weeks to get going. Obviously you could do it longer than that, but that would be my recommendation. How do we know if it's actually working? 1 I. I like to look at people. How do you feel in the morning? Did you wake up feeling like you just slept deeply rather than lay unconscious? Because sometimes you can be too groggy? It's not something people really experience with dip, but it definitely is something to be aware of. Obviously the wearable data, I think is the best objective way that we have today. Whether it's a whoop or an order ring or ringcon, whatever it is. And deep sleep and total sleep, are they improving over the week? I know in my experience, dip, typically I'll see those numbers move in the right direction and also subjectively feel better. And then we look at daytime performance. Is your alertness better without the fog that sleep drugs leave behind? Hopefully it is. And hopefully that's why you would use D SIP instead of things like Trazodone or Ambien. And then after seven to 10 days at a proper dose, nothing has moved. Again. It just might be that you need to combine it with other things. We'll talk about those other things here shortly. But it's, it's one of those things. You, your dose might be too low. You might need some other peptides in there with it to kind of help what's going on. Let's talk about cycling. Is there something that explicitly tells us we need to cycle dip? Not really. DCEP is did not build tolerance in the human trial, so it didn't seem to have a tolerance buildup, which makes continuous nightly use technically Defensible and then people cycle mostly out of caution and also to verify if it's still earning its place. Again, I am less of the opinion that every peptide needs to be eight weeks on and eight weeks off. I think it's a very nuanced contextual discussion. Say like okay, is this getting us where we want to go? Do you need to use DSIP every night of your life? I don't think you would harm yourself doing it, although I just think you might be wasting your money. However, is it something that you can use in cycles to create a cascade of effects that here carry over and then as the stress of life goes on we can bring that back into cycle. And so that's kind of how I think about it. Because D SIP doesn't create dependence. You should not expect a crash when you stop, which is a nice thing of it. I like a couple different things. You can do five days on, two days off. This is the most common pattern. You can do 10 days on and then 10 days off again for those stress blocks. If you have acute times of stress and then situational only. This is more I would say like what I personally do because on the average night, when I have an average day working, going to sleep, I wouldn't say that I need assistance from decept to sleep. I sleep really, really good for the most part because of the things that I do and if there's not some outside stressor event. However, when I am traveling that's where decimp can come very handy to reset my circadian rhythm, help align me with whatever time zone I'm in and then also help the fact that I'm not out of or that I'm out of my normal routine and my normal bed and my normal wind down routine. Uh, because when you're traveling obviously a lot of that goes out the window. Let's talk about long term use. The longest continuous human dosing is about four weeks. So we just don't have anything along that. The longest data set in Russia and rodent work where monthly dosing across the animals whole lifespan was associated with better survival and actually fewer tumors. Again this is reassuring, but is in animals not peaceful. And again we just don't have long term safety data. But I did want to throw that in there because we did have studies done on mice that shows that long term use for the entirety of their lifetime actually resulted in fewer incidences of cancer and a higher incident or a longer lifespan, so to speak. Let's talk about some sequencing with other peptides and I Think when we look at dip, particularly in terms of getting practical results, this is where we will see potentially your DP actually doing something versus not doing something. The first one I want to talk about is epitalon. I haven't done the masterclass on epitalon yet, but that is in the works, I promise. Epitalin restores the upstream timing signal by working on the pineal gland and helping modulate melatonin production. And dip normalizes the structure of sleep once it begins the the epital on sets a schedule and then the D sip improves the work done on that schedule. And again, this is why sometimes leading with D sip alone on a badly mistimed circadian rhythm clock can end up getting subpar results. And I think it's why a lot of times you can either use epitalon leading into D sip or just start using them at the same time together. I kind of like using epitalon initially. So run a 10 day cycle or a 20 day cycle of 1 milligram per night of Epitalin. And then step two would be to introduce DIP toward the end of the course or immediately after at that 500 microgram to 1 milligram range, 30, 60 minute before bed. And then we're gonna get this carryover effect, it seems from epitalon. And then the D sip continues situationally on the chosen cycle. And then we would just repeat that epital on course maybe two or three times per year sometimes. You know, I am becoming more of the opinion that we can use epitalon probably more frequently, especially if it's the oral version. There's this in acetyl epitalon that's making the rounds to which I have had really good results trying. But I think when we, we talk about the injectable epitalon couple times a year we're going to get this carryover effect and then we can use the dip after that or in conjunction with it to really enhance the the effects of it. So I love that. Let's talk about some reconstitution. Dip obviously comes lyophilized power. There is no weird reconstitution nonsense that goes along with this one. You can just use backwater and same rules apply as always. Just don't just shoot it down the side of the vial, don't shake it, keep it refrigerated after being mixed. Typically you're going to see dip come as a 5 milligram vial. In my experience, that's what's mostly out there in the research world. Sometimes you'll see a 2mg vial, but I like to do 5mg bile, add 2mls of water, that makes it 2.5mg per ML and then each unit on an insulin syringe would be 25 micrograms. Thus if I wanted to do 250 micrograms that would be 10 units. If I wanted to do 500 micrograms that would be 20 units. If I wanted to do 1 milligram that would be 40 units. There you go. And like I have on there on the slide if you want to do that, 1 milligram would be 40 units. We talk about injection techniques. Abdomen obviously good 29 to 31 gauge insulin needle. Just make sure you're rotating the injection site and then store correctly. The rule of thumb is obviously like store for 30 days. But I've used dip that's been reconstituted for four or five months in a pen and it was still good to go. What to track? Obviously the subjective one. Just your morning sleep, sleep quality, rest, rest, fullness upon waking, daytime energy, mental clarity, mood, stress, resilience and then compare that versus not using it obviously the way the wearable data. And then I would say after 8 to 12 weeks of cyclical use. Also look at just a comprehensive blood panel that includes CMP, CBC, lipids, fasting, insulin, A1C. I think most people will probably notice improvements in the cortisol would be the best kind of proxy to see if it's working or not. You could also look at CRP and then growth hormone igf. I don't think you're going to see much of a movement in IGF levels, but it does increase growth hormone levels. Talk about some more stacking. Like I mentioned we have epitalon. I think some other good ones to pair are C link, especially for the stress modulation, potentially cmax. If you are doing CMAX in the morning, kind of just going to help with the nootropic and then also helping restore the nighttime access with dip. And then we have melatonin. I think you could absolutely use epital and dip and melatonin together to get a really good effect in terms of melatonin. One thing I've played around with recently is actually using transdermal melatonin. For me that seems to metabolize a lot better than oral melatonin to where I'm not groggy in the morning, but I feel like I got a really, really restful sleep. Take with that what you will. But I think in terms of a sleep Stack dcep, epital and melatonin can work really well. I've actually even seen those in a nasal spray that you can do. I've done that myself and it does work well. I'll talk a little bit about that in a second. We also have the GH secretagogues. I think this is a must do. Obviously I'm a big fan of HGH and the HGH peptides, but when we look at dip, it has documented growth hormone releasing activity through the hypothalamus and pituitary. Thus when we stack with a GHRH or a ghrp it's going to add to the nocturnal GH release which obviously improves body composition but also improves sleep architecture. Then we have SS31. I think SS31 just is one of the greatest peptides. I would probably say it's the second best peptide next to Redis, True Tide or Trap Tide, whatever you would want to crown your king because I know some people like Dr. Zeptide better. It's totally fine. But I would say SS31 it also is going to stabilize the inner mitochondrial membrane. We get DIP protecting mitochondrial respiration and the pairing would be good for chronic fatigue, post viral recovery or ischemia reperfusion scenarios. Also too we have all these cavins and bioregulators. We've talked about Epitalon. I think DIP also works really well with thymin or Penelon and other cabins and peptides that help the neuroendocrine immune system going on there. So I really like it with those and it seems to be pretty synergistic with those. What not to stack. I personally don't recommend benzos Z drugs or sedatives with this. So if you do want to use D Pre, please try to wean yourself off of those if that's something that you're on. Also active opioid use outside a structured supervised withdrawal protocol. I would not recommend doing D SIP with that. And then also high dose somatostatin blocking medications theoretically pulls against DCEP's GH effect. Again there are clinical trials. It's not really the purpose of this today to go into how this is done, but there are clinical trials showing that people that were coming off of alcohol addiction or opioid addiction once they stopped the substance and then went to dcp, manage their withdrawal, reduce seizures and it really helped there. Let's get into some troubleshooting. One, I don't feel anything. Here is probably why you don't feel anything. 1 the dose is too low Again, move up to that 500 microgram to 1 milligram range. That would probably help. Also, expectations. Again, just don't expect this to magically fix all your sleep hygiene issues. One, the duration. Sometimes you gotta give it at least one to two, maybe even four weeks to really notice something happening. Obviously check your source. I don't need to get into that. And then again your problem. So sometimes if you have sleep apnea, untreated depression, caffeine screen issues, again, DCEP is not going to solve those issues for you. Common issues, I would say DIP is a very low side effect peptide as it stands among peptides. But you can't have injection site reactions, so you could get a little redness. It's very, very minimal if I've ever seen that paradoxical arousal. So sometimes people get this arousal from BIP and they end up not sleeping as well. That's usually early on when they first start it and seen some subside after the first week or two. However, in this case, you can absolutely take deep in the morning. So there's no downside to take it in the morning and actually end up sleeping better. And again, I would rather have it 30 to 60 minutes before bed. But if it does arouse you, hey, take it in the morning and you still get the benefits. In my experience, vivid dreams generally benign and reflect dip's effect on sleep stages. I think that's actually a good side effect, but it is a side effect nonetheless. And then sometimes people do get a mild headache again, usually this helps with hydration. It is ameliorated by hydration. And then also too, just once you become acclimated to it. But very, very, I would say mild as peptide side effects go. Is decent legal? No, it's actually. I'm actually filming this on July 24th. It's actually one of the ones being evaluated right now by the Pharmacy Compounding Advisory Committee. Seems to be yesterday actually at the time of this filming, they did pass BPC TB500KPV and what was the other one, mot C to actually be legally compounded now. So they're not FDA approved, but they're able to be made. Hopefully DCEP ends up becoming one of those peptides because I think it can help a lot of people. And then we look at melatonin. DIP and melatonin do different things. Melatonin is a timing hormone, best for jet lag and shift work with former human evidence. Obviously DIP works on depth and structure, but they can work together. And so if your sleep issue is purely timing Melatonin is probably a little bit better if it's fragmented stress driven sleep, DIP target something melatonin doesn't and again use them together. And I also want to pe tell people too that I, I don't think I've covered thus far is DIP does not work to put you to sleep. It can help you stay asleep, but it's not gonna be something that helps you go to sleep. Can you take it orally, sublingually? Not that I know of. I have seen intranasal work, I have tried that and it has worked. But to me injection is still the best. When we look at the half life, uh, again it has a 30 minute blood half life, which is why I recommend 30 to 60 minutes before bed. And this is also why cumulative nightly use builds benefits better than one big dose. And does it cause more morning Dr. Grogginess? Typically no. But everyone's different, right? Everyone has different brain chemistry. So it might in your case is DEC addictive or will it build tolerance? No, there is even no washout period that seems to happen there like some other peptides, maybe like a glp. Why does it keep some people awake? Because it can genuinely in the first hour work to cause an arousing effect depending on the dose and depending on the person. So a lot of it's just because of neurochemistry unique to that person. Does it raise growth hormone? Because that is a circulated kind of thing people talk about. Yes. In animal studies, DIP stimulated GH release through the hypothalamus and pituitary tied to the natural GH pulse during sleep. And whether this translates to meaningful G changes in healthy humans has not been established. I would say probably don't lean on it to be your growth hormone peptide of choice. Can it help with anxiety and stress? Absolutely. It points from the data to decep dampening the stress axis and improving resistance to stress. Although human anxiety evidence is thin, but I would say expect a calming stress buffering effect at night while being honest that, you know, it's not probably the strongest thing, but it can work with other things. Does it help with opioid or alcohol withdrawal? Yes, the older human evidence is surprisingly strong. 1984 trial of 107 patients showed symptoms disappeared or markedly improved in 97%. Pretty good success rate of opioid dependent and 87% of alcohol dependent patients. And again, we don't have modern rigorous trials, probably never will, but it is something to be aware of. And again, when we talk about getting all the benefits of the peptide could be Something that is pretty good there. I'm also quoting off of memory, but I do believe there was one trial that did help with people that were experiencing seizures. Now whether those seizures were related to withdrawal or not, I can't remember. So go look that up. But it does seem to help there too. Can you use it with sleeping pills or trazodone? I would probably stay away from that. I'm not telling you what to do, but I would just say probably stay away with way away from that. Does it work well with TRT or hormone therapy? Yes, I would say they could be very synergistic. Pregnancy, breastfeeding or kids. We cover that. I would just say probably stay away and use your own discretion there. Cost wise, it's usually very affordable. Definitely one of the more affordable peptides. Is FDA approval coming? No, but it does seem like that we're gonna have better access to it now if things trend in the right direction. What do we have in terms of the next future outlook, next generation? I think it's gonna be just more one of those things that anecdotally in the research world or the compounding world via cash bay clinics that you see people move into using, there are some analogs with stronger antioxidant activity than D SIP does. But it's just hard to find those now and hard to have them synthesized. So that could be something that you may see in the future. Just summing up DCIP is, is kind of in this unusual spot. We have 50 years of mechanistic work, but very small actual tangible work on what it practically does from a clinical literature standpoint. I have seen enough anecdotal data in the research world out there to say, hey, this is like probably something that we can feel very, very safe about. But what it has is a solid mechanism, real but old human trials, large Russian tradition of being used and genuine clinical interest from the fda. However, we just lack the modern rigorous blah blah blah trials that are out there. But I always want people to be aware of that. What is the best thing to take away from this one? Just run it right Again, just To sum up, dip is a 9amino acid peptide. It normalizes sleep architecture and dampens the stress axis without sedating you, without bidding, building tolerance and leaving you groggy. Again, the dosing. Just be aware the dosing is 500 micrograms to 1 milligram. And again, it's a tool that works well with good sleep hygiene. It is not going to cover up bad sleep hygiene. And if you're expecting it to do that well, you're coming to the wrong place because it's not going to, not going to do it again. It works best as a tool alongside you already doing the right foundations. It's not going to help you fall asleep. Will help you stay asleep, but don't expect it to overcome a bad lifestyle. As with most peptides, my verdict is the D SIP is not Ambien. Again, people hear sleep peptide, they expect to get knocked out. Not gonna happen. For me Personally, I run 500 micrograms of 1 milligram 36 minutes before bed, situally situ situationally as needed. And then on the withdrawal trials, there's obviously like good data there, but it's not something that I would say is gonna be integrated into most doctors practices anytime soon. And then just summing up it, in my opinion, it's an excellent peptide that gets misused because people expect the wrong thing. It earns its place quietly over time. And like SS31 at the mitochondrial level, it's kind of doing this background work that's just going to make everything work a little bit better. And I think that's the best way to look at it. Choice hotels get you more of what you value. Comfort Inn. It's calling your name. Save on the stain. Oh, and free waffles are yours to claim. Bookdirectsourcehotels.com and that is it for the slides. And that is my masterclass on D sip. Hopefully it was helpful to you guys. This may have been redundant for a lot of you people that are veterans in the peptide world, but hopefully there was a couple nuggets in there that you may not have known even if you are a veteran user of peptides. But I think when it comes to dcep, I love dcep, but I love it for what it is. I don't love it for something that's not, which is, like I said many times today, Ambien. And I think when we talk about it, use it intelligently, use it, use it wisely, and use it with some of those other peptides. Epitalon, thymalin, even if you wanted to do like penelon, melatonin, some of those things, it can work really well to help with those. And I think it, it shines best when it's used in combo with those. Not that you can't use it in isolation, but it seems to work best with those. I'm a fan of it. Is it something that I do every night? No. But I do carry it with me when I'm traveling and I do use it. If there's any sort of stressor in my life that I feel like I need to be a little bit more calm for because it does help modulate that stress response. And goodness knows I have struggled with my fair share of cortisol issues in the past. Again, you can talk about all the peptides in the world, but when we talk about lifestyle, stress is part of life. And that's what's amazing about peptides. We can kind of use some of these things to help mitigate the stress or help our resilience to stress. And I love DCEP for that reason. So in closing, thank you guys. I just always want you to walk away and know that my heart overflows with gratitude for all you guys out there that help support this work. Whether it's just watching, liking and coming, subscribing, being on the email list, using my code in places, being in my community. You guys have no idea how far that goes in helping me bring these messages to you guys that hopefully improve your life and ultimately too if you're sharing this with friends and family, that goes so far. Because as you very well know, this is not things, these are not things that get picked up by the algorithm. And so the more we have this on, on the ground, boots on the ground, gorilla type, I wouldn't call it warfare, but whatever we are doing in the peptide world out there, networking, coming together, sharing this information, helping each other become better, having other people create content that do really good work. So just thank you guys so much. I'm so blessed and grateful to get to do what I do. So thank you guys. I promise to keep these master classes coming. Looking forward to your feedback and I will see you in the next one. Peace.