← The Hunter Williams Podcast
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Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world today is going to be the master class for ipamorelin. Ipamorelin I think is probably one of the better gateway peptides, meaning that for people that are new to the peptide world, I love introducing them to a few peptides. One is BPC, another TB500. But I think when we talk about the growth hormone peptide class, I really think ipamorelin is probably the best peptide for someone to get started with. Doesn't mean it's the best peptide out of the growth hormone peptides. It's up there, but I wouldn't say it is the absolute best and obviously that is relative to your goals. But when we do talk about introducing someone to the class of growth hormone peptides for the very first time, if they've never done growth hormone or growth hormone peptides, I love introducing them to ipamorelin for the reasons that I'm going to talk about today. Seems like these masterclasses are getting really good feedback, which is exciting for me because this is my favorite type of content to prepare and make. But thank you guys so much for the feedback and support. As always, make sure you're on the email list in case there are any types of censorship that do come up in the future. And also too, if you want to check out my private group or you have direct access to message me privately or message a group and come on live calls and ask me questions, you can check out the Axion Collective that will always be in my links down below in the description of wherever you're watching this. And then lastly, if you want, check out my AI chat tool. Last time I checked we had like 8 or 9,000 active users on there, which is pretty cool. It seems like people are really enjoying that so far. And again, that's more just more or less just a tool to be able to access my video transcript library and interact with it in a Q and A based format. So thank you guys so much for that and without further ado, I'm going to share my screen and today we're going to talk about ipamorelin. All right, let's get into it. Today's going to be the ipamorelin masterclass. Looking forward to this one. What we're going to talk about first is one what ipamorelin is what it does inside the body, obviously for different goals, when it might be appropriate or when it might be appropriate to use a different peptide in the growth hormone class, we're obviously going to talk about how to stack it with CJC 1295 no DAC. I think that's one of the most important things. Obviously that's a different peptide that will have its own masterclass. But when we talk about CJC 1295 you would be remiss not to mention IPAMLIN or vice versa and how important it is to understand why we're stacking those, but then also best practices around how to do it because it's probably not what you think. Obviously we'll talk about reconstitution then how to track it, what labs run, what subjective markers to look at and then some of the evidence that we have. It is not one that I say we have an overwhelming preponderance of human evidence, but it is still important we look at ipamilin in terms of the growth hormone class. It is, as far as I know, the cleanest growth hormone releasing peptide. So it exists in the category of ghrp, growth hormone releasing peptide and we'll talk about what that means today. But basically it pushes out growth hormone without dragging cortisol, prolactin or appetite increases with it. And that selectivity is why it's probably one of the better compounds to use. And again, I think underrated relative to the things people are out using in the research world in the wild today we look at ipamilin. It is a pentapeptide, which is a chain of five amino acids with the sequence AIb, His, D2NAl, D, P, H, E, L, Y, S, N, H2 I would rather say ipamorelin, but its molecular weight is around seven hundred and twelve Daltons and its half life is roughly two hours. Discovered in the mid-90s by a chemistry team at Novo Nordisk in Denmark and they actually started with an older peptide called GHRP1. You've probably heard of GHRP2 and GHRP6 and they systematically strip pieces off while testing for growth hormone release. And what emerged was what we have now as ipamorelin. And it's as powerful as some of the older peptides like the GHRP2s and 6s but without their messy side effects. And again, the discovery was published in the European journal of Endocrinology first in actually 1998, which is pretty cool when we look at the history of it. Mid-90s is when Novo Nordisk discovers ipamorelin. Rigorous early human pharmacokinetics studies were conducted then. Didn't seem to have any issues. 98 to 99 discovery and pharmacokinetic papers were published, Novo's commercial interests cooled and they really just didn't pick it back up. In the late 2000s, there was another company called Helson Therapeutics picked it up for post operative ILUs, which is a real gut motility problem, which I'll talk about today in relation to GLP1s. 2014, we have phase 2 trial and 114 bowel resection patients. The safety was clean, but the drug failed to beat placebo in that specific use case. And then 2014 it basically just reached a commercial dead end. They dropped ipamorelin into the longevity and compounded peptide space where today it is thriving in the research world and hopefully it'll be moved from category two to category one as these things are taking place in the regulatory environment and that is ongoing. Let's talk about the system that it acts on. Basically, our pituitary gland fires growth hormone in six to 10 different pulses per day, with the biggest pulse being obviously during sleep. Two signals control it. We have one, which is ghrh, that stands for growth hormone releasing hormone. And we have also this thing called somatostatin. Think of JHRH as the accelerator pushing it. And then somatostatin is kind of the brakes on it. A third input, which is ghrelin, is our stomach hunger hormone also triggers GH release through its own receptor, which is known as GHSR1A. And the GSHR1A receptor was discovered by Andrew Howard's team at Merck in 1996. And its natural key, which is gin, was found by two scientists in 1999. Ipamorelin is a synthetic key to cut into that GS. Excuse me, GHSR1A lock, meaning that it is more or less a G agonist. And this is kind of how we categorize the growth hormone releasing peptides as working via this GIN pathway. Whereas the GHRHs, like your Tess and CJCs and Serlins, or growth hormone releasing hormones which, which work via the pituitary. So let's look at this pituitary GH pulse control. We have pituitary somatotrophs which integrate inputs into the GH pulses to fire GH pulses. We then have growth hormone releasing hormone which stimulates somatotroph GH release. Then we have somatostatin, which is the break that inhibits GH secretion from the pituitary. And then we have this ghrelin, GHSR1A, which enhances GH pulse amplitude when our pituitary is making it. Now let's look at what ipamorelin is actually doing mechanistically that will then lead to some of the effects that most people are using for the first thing is that binds to this GH GHSR1A receptor travels to the pituitary after you inject it and binds the ghrelin receptor on somatrop cells, triggering a triggering a calcium driven cascade. What then happens after that is that GH rises within 15 to 30 minutes of subcutaneous injection, usually peaks around 40 minutes and returns to baseline in about three hours. And then again it amplifies, it does not override. And so when we add one pulse on top of our body's existing ribbon rhythm, we do not flatten or suppress our natural pulse generator, which is obviously what makes the peptides different from actual HGH use itself. And then ultimately what happens is that the GH signals that are now amplified signal deliver to produce IGF1 which causes and carry outs, carries out most of the downstream tissue effects. And again this is what we're actually able to track, at least in the best way we can. When we talk about using growth hormone peptides to get results, that's usually the proxy that you will use. But ultimately it's the IGF1 increase that is then going to cause better fat loss, better sleep, better hair, skin and nails, and overall just a better state of well being for most people. So remember that when we talk about growth hormone peptides, it's not so much the growth hormone as it is the IGF one that comes out of the growth hormone that then has the effects. Let's talk about why Ipamorelin is unique in this class of GHRPs. Because like I said, we have GHRP2 and GHRP6. We also have one called hexarelin which is really, really strong. But in a lot of cases it's not the best thing to use because it can be so strong and we desensitize to it very fast. But they all bind to this GHSR1A receptor. And what is unique about ipamorelin is it does so so cleanly without any of the side effects one we don't get any of the cortisol spikes. So in the original 1988 study it Ipamorelin did not raise cortisol or ACTH even at doses 200 times higher than the growth hormone releasing dose, which was basically just the minimum threshold dose dose to raise growth hormone. GHRP6 and GHRP2 both raised stress hormones and cortisol in the same model that they tested the Second thing is we don't get an elevation in prolactin. Prolactin stays flat at normal doses and this is a critical advantage for long term, long term use, especially for women. But also min to we don't want prolactin too high because a lot of times that will suppress libido, which is obviously not good. And then lastly we get minimal hunger, unlike GHRP6 which is notorious for triggering intense hunger. Also MK677, although it's not technically a peptide, it's small molecule does the same thing. Ipamilin's appetite effect is mild and manageable at therapeutic doses. And in my practical experience I rarely ever, maybe one or two times I've heard people say that their appetite went up on ipamorelin, whereas with Tess it definitely can. Obviously MK677, GHRP2, GHRP6, those can too. Basically the clean cortisol and prolactin profile is the entire reason ipamorelin is still around today and why some of those other ones like GHRP2 and GHRP6 really don't hang around. Basically, if you inject something daily for years, you cannot afford slow upward drift and stress hormones, which is why those other ones are not long term candidates. You can use them obviously and very acute phases for acute reasons, like if you wanted to increase your appetite or if you wanted just a quick pulse of growth hormone or for instance with hexarelin. In a lot of cases there's benefits for API, excuse me, AFIB and cardiac tissue from hexarelin, but it would not be something that you'd be able to use long term like you would Ipinerelin in terms of doing it for several months at a time, several times throughout the year. Let's look at some of the effects beyond growth hormone because this is pretty cool and I think when we look at Ipamorelin, what makes it stand out especially relative to Tesamorelin or C cjc Some of these things are pretty cool and I think could be potentially synergistic with other peptides that we're using when we get effects on the bone. In rats, ipamorelin increased bone mineral content and counteracted steroid induced bone loss. Another good reason not to use corticosteroids. But the ghrelin receptor is expressed directly on bone forming cells, suggesting a local signal beyond GH and IGF1, which is pretty cool because again when we talk about tesmerelin, cjc, not really getting that, would we get an increase in Bone density from those potentially. But we do have direct evidence that ipamorelin is actually using that for improving bone density, which could be pretty cool, especially when we talk about sarcopenia, post menopause, frailty and things like that. Nature, things of that nature. It could be very useful. We have gut motility, and this is what is pretty interesting. When we agonize the scrub receptor, specifically through Ipamorelin, it actually speeds gut movement through this gut ghrelin receptor independent of growth hormone release. And again, this is why Helson developed it for postoperative ILUs, which is the mechanism be. Which is the mechanism that they were looking to agonize through using ipamilin, although it failed in the trial. I do think for the average person, they could actually get an improvement in gut motility from ipamorelin. Now, is it going to be as strong as something like oxytocin or vip? No. If you're struggling with constipation, I would use those first. But for someone on glp, I think you could do yourself a whole world of good from using ipamorelin1 because you're going to support muscle mass, bone density, better sleep, better hair, skin and nails. But also too, we get an improvement in gut motility, which, when we're slowing gastric emptying, can be uncomfortable for some people if they're not managing it properly. Obviously, we have sleep users consistently report deeper, more restorative sleep within the first one to two weeks, often before any body composition change. That's usually always one of the leading things that people notice is right away they're sleeping better. And again, this makes sense based on the mechanisms that we know about. Let's talk about some of the people that this is for. Who is a good candidate for Irellin and maybe who isn't the first one. I would say Anyone usually over 35 is going to be a candidate. If you're walking the earth and you're over really 30, but 35, you could probably stand a benefit from growth hormone peptides. You train hard, recovery is slower than it used to be, and you want better sleep, faster healing and less soreness. This would be the number one use case, I think, for Perry and postmenopausal women, especially if they have not introduced themselves to growth hormone yet. This is a very good gateway into helping. Helping with that. When we have declining estrogen, that's obviously going to hit sleep, body comp, bones, skin and hair all at the same time. Ipamorelin addresses several of these at once. And the clean cortisol and prolactin profile matters even more for this cohort of women. And again, I think this is one of the strongest and most underused applications. I will say if there is one avatar of person that I immediately think of with IPAM relin, it's the women in their 40s and 50s. They've probably never been introduced to a growth hormone peptide and I think ipamorelin even in isolation can do them a world of good. And obviously I would like them to optimize their hormones. But maybe even sometime if that's not an option or they're not ready to go down that path, ipamorelin can be a nice gateway for them to get into hrt. Obviously for someone wanting to optimize body composition, if you're training in nutrition or dial in and you want a measurable edge on visceral fat and lean mass over a 6 to 12 marble month arc, you can obviously, obviously stack it with CJC and healthy lifestyle and it'll work well. And then for people that either are poor sleepers, you're curious about HGH or you're longevity minded, deeper sleep is the most consistent early report. Like I said, if you want GH benefits without the synthetic H financial cost or maybe you're just not ready to go down that path yet. It can be a very good intro into the class and obviously too and I think when we look at longevity it's easier to make the argument if someone is using synthetic growth hormone that maybe that's not the best thing for longevity. I think you could make as as much an argument in the other direction when we talk about ipamorelin, especially for how mild it is. I really see almost zero downside whatsoever to someone using ipamilin. And I'll just go and say I see zero downside, meaning that with peptides the body seems to have this self regulating mechanism of how high it will allow GH to go. And with something like ipamorelin it's not going to be super physiological. In a lot of cases it might not even be substantially that much more from what you're already making. But we do seem to see a lot of these good side effects in people that are using it who should skip it. Obviously it's not going to fix a broken bone, things like that. It can work synergistically with healing peptides. But again if you're not going to live a healthy lifestyle, I would think you're, you're probably wasting your money. Again if you're, if you're super young. Sometimes I think some of the peptides aren't really going to do that much. And then if you have active cancer, just be aware with growth hormone peptides that could potentially exacerbate it. Talk with your doctor. Pregnancy of breastfeeding or severe untreated sleep apnea, obviously treat, treat the sleep apnea first. I think a lot of people, they're looking for peptides, help them sleep. And sometimes there's some underlying issues that they have not addressed. Dosing is very simple. I only really have two tiers of dosing. One would just be general optimization. 100 to 200 micrograms of ipamilin once daily before bed. And then if you wanted to, you could pair that with 100 micrograms of CJC, no DAC. This is gonna be the maintenance dose for sleep recovery and longevity. And most people never meet in more than this. I would even say that there seems to be a threshold dose of ipinerellin beyond which it doesn't really matter how much more you take, doesn't do any extra work. I think that's 300 micrograms. I really haven't seen any more benefits taking 500 micrograms in terms of any practical effects that it has. When I do stack it with CJC, there's kind of two ratios. Some people like a one to one, I'm more of the one to one ratio. Some people like a three to one, meaning three parts Ipamoran to one part CJC, which would mean 300 micrograms of IPA and 100 micrograms of CJC. But again I lean towards the one to one. And then for tier two, this is going to be for performance and body composition optimization. 200 to 300 micrograms per dose, two to three times daily. And you could definitely do it multiple times daily if you wanted to. And then if you wanted to, you could obviously pair that in the ratio that I mentioned with cjc. Again, this is gonna be for active recomp alongside hard training and high protein. Pre bed dose is always the most important one. But I would say for someone, if you're gonna be anal retentive, you could do pre bed and then you could do pre and post training I think would also be good. The thing about it though is that pre and post training, I'm not a fan of weight training fasted, but you wanna make sure you're fasted when you're doing it. And so maybe you would do it like an hour before training and then eat right before training to let it hit and then kind of the same thing, maybe wait a little bit after training, take your ipammelin right away after the training and then wait like an hour or so to eat. But again, not 100% necessary. At the end of the day, if you want to be lazy like me, just take it before bed and you're usually going to get good results. And again, it seems to be like at that 200 to 300 microgram range, you're not getting a bigger pulse, you're just gonna cause more receptor desensitization and IGF1 feedback. And again, that's why, another reason that I'm not a huge fan of pushing the dose up, because you're basically just gonna, especially for something that's not giving you outsized benefit, you're just gonna desensitize faster at a higher dose. And although that's not the case with every peptide with Ipammelin, it is definitely the case. Longevity anti aging again, 100 to 200 micrograms. Timing wise, I like five days on, two days off. And you could do this for at least 12 weeks and then take a two week break. A lot of people are like, hey, can I use this year round? I wouldn't do it every single day for the entire year. But just be smart of how you cycle it. Whether it's 12 on, 4 off, 8 on, 8 off, however you wanna do it, or if you wanna go back and forth to a growth hormone releasing hormone, you could do that as well. For the athletic performance, that's gonna be the higher dosing, usually at longer periods. And then just for sleep, lower dose probably is enough to get you the sleep that you want. So again, just play around with the dosing and see what works best for you. When we talk about timing, fasting and frequency, the pre bed dose is non negotiable. This is the one that is most important. I, I know some people don't do well with CJC at night. I think that's fine to take in the morning. So it seems like less people do well with the GHRHs at night. But if you're stacking the peptide pulse on top of your largest natural deep sleep GH pulse, you're gonna get better results. And the combined amplitude does most of the work. If you only take one dose a day, please make it a pre bed dose. Some rules dose at least 90 minutes after your last meal. Avoid eating for 30, 60 minutes after injecting carbs and fat blunt the GH pulse. Inject on a relatively empty stomach. I know there's a big Question now around if my GLPs are slowing gastric emptying, do I have to wait longer? I think you're probably okay. Just make sure it's not like a massive meal and also make sure you're giving yourself at least 60 minutes to 90 minutes. But again I don't think it's one of those things. You have to wait four hours to do your ipamorelin injection space multiple doses by at least three hours. So each lands on a clean baseline. And then the common two do pattern is morning fasted and pre bed. And obviously you can do pre workout or post workout however you want to do it. I think that's less important in my experience. Let's talk about timeline and expectations. With week one you're going to notice deeper, more restorative sleep. Vivid dreams are usually common and this is a good sign. It is a sign that it's working. Weeks two to three we see better recovery from training and less day to day soreness. Weeks 6 to 8 typically this is where you're gonna see sub objectively on the the blood work, the IGF one climbing into the upper third of your age range. And then the body composition hopefully begins to shift. Weeks 8 to 12 typically is where you're gonna see more of the visible body composition changes with adequate training and protein. And then months 6 to 12 again we see better sleep recovery, modest fat loss, lean mass support, fewer injuries usually because of better collagen signaling, better skin and hair. And again this is going to be the compounded effect through doing cycles multiple times throughout the year. And again most people who quit early do so because they're expecting a transformation in the first month. And that is not always how this works, as you guys probably know. Now let's talk about why cycling at all. One, the ghrelin receptor can desensitize with constant high amplitude stimulation. I think when we talk about cycling peptides this would definitely be in the category of ones that you will desensitize to and it will basically stop working after a point regardless of the dose. Whereas with some of the other peptides you can keep taking up the dose. And for instance with a GLP you can keep taking up that dose and you're get better effects. You're obviously desensitizing to it, but you are able to kind of get what you want from going to a higher dose. Ipinella is not really gonna work, but like that basically the lock becomes less responsive to the key over time so the same dose produces a smaller pulse. And then when we cycle this keeps the receptor sensitive and gives rise our feedback loops a chance to reset and then get the results that we want to. Again, Iparellin is gentler on the receptors than the peptide hexarelin. But the same principle still holds. And the reviews of the growth hormone secretag class support cycling as the safer long term approach for this reason. And again, ultimately it preserves the response and prevents dose creep. That does nothing but raise your risk profile over time. Some of the cycling patterns obviously I like five days on, two days off. Even just taking those two days really does help reset the receptors a little bit, which allows you to extend the cumulative cycle a little bit longer than if you were doing seven days a week. I like eight weeks on, four weeks off or 12 weeks on, four weeks off, either of those is fine. Most people do start to notice the results begin to diminish in that 8 to 12 week window. And so if you want to run it longer, that's fine. If you want to run it shorter, that's fine. And you could do the same amount of time off. But if you weren't doing anything else, like if you were not using another growth hormone peptide, I think four weeks is plenty of time off. And then again, if you wanted to do continuous low dose with just one week break here or there, I think that could also be beneficial too. Just understand that you kind of have to see for yourself what is the amount of time off that you need to reset your receptors, because that's usually going to look a lot different for everyone. Let's talk about the core pairing of ipamorelin and CJC Nodac. Okay, let's go over mechanistically again what's going on here so you guys understand how important this is. One, we have Ipamorelin opening the ghrelin lock, which is obviously the GHSR1A receptor. Then we have CJC, no DAC, pressing the GHRH accelerator through a different receptor. And the somatotroph cells respond to both pathways simultaneously. And the combined pulse is 3 to times 3 to 10 times larger than either compound alone. Again, which kind of has this one plus one equals three effects. When we talk about cjc, I like the no DAC version. The DAC version extends the half life to five to eight days, which I don't think is the best thing to do for growth hormone because again, we want it to operate in a pulsatile fashion. Again, this keeps GHRA signaling elevated continuously, which flattens the natural pulse pattern, which is the same tonic exposure problem you are avoiding by not using HGH at multiple doses per day. And again, the Nodak version preserves the pulse, which is the whole point. And then standard pairing. I like the one to one. You could do the three to one, meaning three parts Hyperrella and one part CJC. But I like one to one and you could do 150 micrograms of both if you wanted to. You could even do 300 micrograms of both if you're really going to go big and take that up. I think in most cases, Even for me, 150 micrograms of both seems to do really well and you just get this synergistic effect. I will say this. I like starting with ipamorelin just by itself. I think that's a very important thing to understand because some people take IPA and CJC right away and they have a bad reaction to the CJC and then they, they just don't want anything to do with it. I like priming the body with ipamorelin. Make sure that you respond good to it. And even if you know you're going to eventually do IPA and CJC together, just use four weeks or eight weeks of IP and relin by itself and then layer in the CJC after and do it at a low dose. And if you don't respond well, then you know to just pull it out and you can go back to using it from Marlin. But I've talked to so many people and they just buy the blend because they think that's more is better and they have a bad reaction and they just end up not wanting to do it and just never revisiting them. Talking about foundation, obviously fix thyroid and sex hormones first. Always, always, always. When you talk about the GH peptides, they're not going to really do anything if your other hormones are not working properly, they will never address a testosterone deficiency, not really going to address a thyroid deficiency. And again, we can then layer in the GH peptides on top of that. And then again, if you really wanted to, for recovery or if you have an injury or something, you could use a BPC and TB500. But again, that's just so important. IPAM, Relin, Tessellin, CJC, all these peptides work so much better when testosterone is optimized. And for anyone that doesn't believe me, take someone with low testosterone introducing these peptides, maybe they sleep a little bit better, but that's going to be about it. They're really not going to change their body comp, whereas when we have optimized levels of testosterone, the increased growth hormone works alongside the testosterone to enhance and, and have a synergistic effect that then changes our body. Again, one of the reasons so and so, so, so important to address hormones. First we can talk about stacking. I will say so. One of the stacks I will mention is IPAM and Tesrellin. As far as peptides go, this is the absolute strongest stack of peptides. I guess technically you could do Tessin and hexamin. I don't know why anyone want to do that because it would probably be so uncomfortable of how you would feel, meaning that you would have so much water retention. But obviously, Tess, this is going to be a ghrh. It sits on the other side of the growth hormone peptide equation. And then a visceral fat is your single most dominant problem. TESS is the targeted choice. But for broader longevity and sleep and recovery using ipamilin and cjc. No, DAC is more flexible and cheaper. I would say for someone that wants to put on size and for whatever reason, you don't want to use growth hormone, Tessamorelin, Epirelin will definitely help you put on size. It will be a very, very powerful combination for me, so much so that I end up feeling kind of bloated. Whereas if I just do ipamilin alone or tesamorelin alone, I don't really feel as bloated when I do combine them. There definitely is a little bit of bloat there, but that's why a lot of people just using ipamilin with CJC because it's not as strong. But you still get more effect than just the marellin alone. Obviously BPC and TB500, they drive blood vessel growth and help repair torn tissue. And again, the GH stack supplies the systemic trophic IGF1 signal. Together they are kind of the standard for injured rehab. That's part of the Wolverine stack. If you're doing everything and then also cool. What's, what's cool too is that BPC and TB500 are gonna help upregulate growth hormone receptor sensitivity, meaning that we get more results out of our IPAM relin, which is cool. SS31, I think pretty much every peptide pairs well with SS31. Just going to help us with mitochondrial health, which again is going to have a better effect when we are taking ipam because our mitochondria are going to be in better shape. And then obviously GLP1s retrutide, they work so well. I think this is One of the things I know, Iperon is not FDA approved. If you just gave everyone on a GLP1A growth hormone peptide like IPAM relinquish, you'd solve probably 80% of the issues that people are dealing with now. One, because we help preserve muscle mass, we're also going to lose better, lose fat better, we're going to sleep better. But ultimately with Ipamorelin we get that improvement in gut motility, which is going to maybe not negate, but definitely mitigate some of the side effects that other people have. And just when we talk about GLP1s with ipamorelin, again it's pulling blood sugar in opposite directions. Ipine seems to really not affect blood sugar the way that maybe a Tesrellin or HGH will. However, just understand that it could potentially raise blood sugar. Obviously GLP1s are dropping blood sugar, so you kind of have this net neutral effect, but you're still getting all the other the other benefits. But again, GLP1 drugs blunt hunger and Iparellin's brief post dose hunger nudge is tiny by comparison to the other ones. But we still get a benefit of the GLP one with that. And I think for the people that do struggle with agonizing growth hormone or using something along the growth hormone pathway to increase their appetite, the GLP one can be a nice counter that to keep their appetite from going crazy and going wild. What should we not stack? You definitely don't want to stack up and run with some of the other GHRPs which would be GHRP2, GHRP6, Hexarelin, even MK677 or MK777. It would just be redundant to stack it because they're hitting the same receptor. You would not need to use those in conjunction. Obviously don't use a somatostatin analog because these directly block GH release at the pituitary which will net out the effect of ipamorelin and then again with multiple new peptides at once. Especially if you're using ipamilin. As a beginner into and getting kind of your feet wet in the peptide world, I am not a fan of just dumping a bunch of peptides at once. I'm not even a fan of using IPA and CJC together at first. I only like that after someone's been acclimated to ipamorelin and then obviously trt, estrogen, progesterone, HRT and Serumorelin are all fine to pair with ipam. Just make sure that you're getting your hormones checked because that's, that's always gonna be a good foundation. Let's talk about reconstitution. The good thing is ipamorellin. All you have to do is mix it with backwater and it usually doesn't have any issues. Typically you're gonna see a 5 milligram or a 10 milligram bottle of Ipamorelin. I would recommend adding 2 mls of water. If you did a 5 milligram vial with 2 mls of water, 150 micrograms would be 6 units. If you had a 10 milligram vial with 2mls of water, 150 microgram would be 3 units. This is one of those ones. Because the dose is smaller, you're typically going to have less units per the amount of backwater that you have. And again, same thing. Nothing new needed. With Iparellin that's different from any other peptide. Just shoot the backwater down the side of the syringe slowly. Don't shoot it right into the puck of the peptide. Let it dissolve and then obviously refrigerate it. And I always like to label mine with how much water I added to it just so I know the dosing. I don't have to think, oh, did I put 2 mls or 1 mls or 3 mls of water into this one injection site? The, the easiest thing with this is just to inject to the fat layer, whether it's in your belly, thigh or wherever, and rotate sites. The good thing about ipamrelin is almost no one has injection site reactions. Whereas with CJC almost everyone. Not everyone, almost. I would say probably 30% of people do have an injection site reaction. Just make sure you're rotating again if you get anything, it's usually just a little bit of mild redness. But I will say ion is one of the most side of free side effect free peptides that we have out there. And again, just keep it in the fridge. And if you're traveling with it, make sure you keep it on ice. Some subjective markers to track. One is energy. Two is recovery. Three, sleep quality. Four, mental clarity. Because we do see that with peptides, especially GH peptides, then training capacity and mood. And again, just make sure that you're doing that to see if it's a good peptide for you. Then objectively we can look at IGF1. Obviously that's the biggest proxy to tell how it's working. Usually it's not going to take you up much more than like 300. I've rarely seen IP like take someone into three 50s or four hundreds, but it definitely can get you to 250 to 280 to somewhere in that range. Fasting glucose, obviously track it. A1C track it. Fasting insulin, track it. Prolactin, if you do want to get that measured just to make sure because the other GHRPs do have it. And in one way it's probably a good, good test to make sure that you're actually getting a real IPamorelin. And then obviously you can get a comprehensive comprehensive metabolic panel and lipids and then a full thyroid panel just to make sure that you're optimizing that because it's very important to optimize the thyroid axis alongside the GH axis. Then you could get that done, you know, if you wanted to, every three to six months. Wearable data is good, grip strength is obviously good. And then body composition. If you could do a DEXA scan, it's also very helpful too. Let's talk about some troubleshooting. I think the first one, as with mo most peptides is I don't feel anything. And again this could be because your baseline is already good. Your IGF one might already be sitting in that 250 to 300 range naturally. Cuz that can happen for some people, so you might not notice any difference. If that's the case, your dose could be too low. And again, if you start with 100 micrograms, work your way up to 300 micrograms. I definitely think there's a benefit to go from 100 to 300. Again beyond 300, I don't know that there's that much more. Obviously you haven't given enough time. If it doesn't feel any different in the first week, again it's really going to take at least 6 to 8 to 12 weeks to feel something. You just got to be patient with these. And that's with any growth hormone peptide or growth hormone itself. It really is a cumulative effect over time. Again, just check your source, make sure that it actually is ipamorelin and then an underlying issue could be blunting the response. If you have untreated thyroid issues, low testosterone, poor sleep hygiene or chronic stress. I don't know how much IP is going to do and I don't know how much any growth hormone peptides we're going to do for that matter. Common side effects, injection site reactions can be common. Again I would say less common than other peptides, but that's like the main thing. You could get a little hungry. Again, it doesn't increase appetite as much as those other ones, but you could get a little hungry. Just be aware of that. Water retention is definitely a plausible thing that happens. I will say out of all the growth hormone peptides, you get the best results with the least amount of water. Water retention with ipam, in my experience, obviously vivid dreams could become something that is part of your sleep now and then. Sometimes people do get headaches within the first few minutes after injection and then those typically go the way again. If you're just feeling worse at month two, maybe just look at, look at your labs, look at how you feel and maybe it's just not the peptide for you. When did it discontinue? If for any reason your IGF is super, super high to the point of being dangerous, which I would say is probably way beyond 500, you might want to look at discontinuing again. I've never seen that. Obviously glucose trending in the wrong direction. I will say if you're, if you're refusing to exercise, your diet or anything, I don't know that ipamorelin won't raise your blood sugar. It could be possible. And then again, if you get numbness or tingling, obviously that's from IGF and growth hormone. Being too high rarely happens with Ipinerellin, but I just put it out there and then obviously cancer diagnosis. I would just say for anyone that knows that they might have cancer, it might not be the best thing. You gotta decide that for yourself. Let's talk about some, some FAQs. Is zipper Merlin legal? Like I said, it is looking at being moved from category two to category one. Meaning that compounding pharmacies will hopefully be able to make it in the future and then we will be able to get it prescribed via doctors, via telemedicine or your local clinics or wherever. Will it make me gain weight? Not in the way most people fear. If anything, you might get a small bump from water retention or increased muscle mass. But typically it's not just going to pile on excess weight. Can you take it orally or is this nasal spray? No, not in my experience. I would say if you want to do. The closest thing to oral ipamorell and I have seen is the, the small molecule MK777, if you want to check that out. I've had really good experiences myself with that. Will it show up on a drug test? It's possible. It is banned by wada. Again, whether or not they can actually get that to show up on a urine test, I don't know. But I always just tell people it is banned. And if you did test Positive for it, you could potentially get suspended. Will you become dependent on it or crash when you stop? No, there's no addiction, withdrawal, crash. And the good thing about the peptides is you just go back down to baseline. It's not something where you completely shut off your natural production. And I'd never worry about that with the peptides. And obviously, can you mix IPA and CJC in the same syringe? Yes, there are peptide vials that come blended as this and if you got them separately because you wanted to control a ratio, you could obviously mix in the same syringe and then just inject in one injection. Just be aware that the CJC is probably the culprit if you are getting injection site redness or hives or itching or things like that. Let's talk about cancer risk and blood sugar. There was a large meta analysis found that higher circul IGF1 is associated with a moderately, moderately increased risk of prostate, premenopausal breast and colorectin cancer. And again, I just put this out there because there's as many studies that show this as there's ones that. Not again, if you do have a history of cancer and you're really, really just blasting growth hormone peptides, it might not be this best thing. But ultimately I put this in here to say even with that, at the end of the day I do not worry about my HGH or my growth hormone peptides as it relates to cancer. Especially considering everything else I do to make sure that I am staying on top of my metabolic health. Can women use ipammelin? Yes, I would actually say it's one of the better peptides for women all around. Women seem to like this peptide more than men because the effects seem to work better for them. What about MK? MK677 versus IP? MK is an oral pill hitting the same G receptor, but it produces continuous around the clock stimulation rather than a clean pulse. It also causes stronger hunger and water retention. In the two year human trial documented a measurable drop in insulin sensitivity which is. It's very rare if you've taken MK677. And again, injectable IPAM relin gives you the pulse and softer metabolic signal at the cost of having to use a needle. What if you take more than recommended? Honestly, probably nothing's going to happen. I think you're just wasting your money and you're causing yourself to desensitize faster. Will it help with long, long Covid, chronic fatigue or fibromyalgia? Not really. I think it could be beneficial, but I don't know that it's going to solve those problems for people, obviously, from a regulatory standpoint. 2023, FDA restricted Ipyron's compounding status because it was being compounded by a lot of pharmacies and written off label prescriptions. For 2024, obviously the lawsuit moving, moving it and having access partially restored. But then 2024 to 2025, the Pharmacy Compounding Advisory Committee, otherwise known as PCAC, votes against recommending it for the official compounding list. And then in 2026, the FDA scheduled further advisory meetings on the batch of peptides of which ipamorellin was included. So hopefully we have better access to it in the future. Again, just honestly, ipamorelin is a very mature molecule. It is very safe to use. It is one of the ones that I would say it's almost one of the best peptides to get people into using peptides. Obviously we don't have a lot of human trial evidence and I think that's okay. I've seen so much anecdotal data around ipamrellin. I think it's totally fine. And then when we look at the frontier, I think we're, we're probably moving into finding maybe even better versions of this. But I even think IPA and cjc, no dac will stand the test of a long time in terms of people getting really good results, improving their body composition, and then maybe one day when they want to move over to growth hormone, being able to do that because they're comfortable with using IPA and CHC again, just to, just to give you a takeaway, iparellin is super clean. It is perhaps one of the most cleanest peptides out there. But always make sure that you are addressing the foundations first and tracking things and doing your due diligence when it comes to your own research. But if you're over 35, your basics are dialed in and you want one stacked to start with for the long arc of feeling and looking like the best version of yourself. Ipam relin starting out by itself and then eventually pairing it with cjc. No, DAC is a very, very good place to, to begin, especially for people that are already living a healthy lifestyle. And that is it for the slides. And that is my master class on iParellen. Hopefully you enjoyed watching it as much as I enjoyed making it. I think when we look at Ipermellon again, I think the, the thing that if I could drive home for me, especially for a lot of you people out there that watch me and maybe you help a lot of other people with peptides. I think ipamilin is one of the cleanest, safest, easiest peptides to introduce someone to help them get their feet wet in the peptide world. Because a lot of times they do feel it pretty, pretty, pretty soon, you know, they, they feel asleep and then they'll start to see their body change, hopefully. Obviously it pairs really nicely with GLPs. If people are starting GLPs, I would almost require them to get on ipamorelin just to have, have some support for their muscle mass and metabolic health alongside of it. But I love ipamilin for that reason. Do I personally use it often? Not really. Again, I'm usually using two IUs of growth hormone per night, but I will rotate it in from time to time. Sometimes I'll do IPPA and cjc. Sometimes I'll do TESSA and ipa. If I really want to put on size for whatever reason, which right now I don't, sometimes I'll use MK777, which is more of like an oral analog for ipamorelin. And again, I do think it is a very useful peptide that in some cases, even if you're on hgh, you could potentially use alongside of that at different times throughout the year to enhance your results and just help with the natural stimulation of the pituitary via the ghrelin receptor there. But that's it for this one. Thank you guys so much. In closing, it is truly an honor and a privilege for me to be able to bring these messages to you. So whatever shape, form or fashion, it is that you support me, whether it's using my coded places, sharing this with your friends and family, being in my private group, or even just watching and never doing anything like that. And you just help the view count. It goes so far in helping me bring these messages you, but obviously I rely so much on you guys feedback. Without you guys, I don't exist. And the more feedback that I get from you, the better content I can make. So thank you, thank you, thank you so much wherever you're at. And again, whatever shape, form or fashion is, you support me as always. Check out the links if you want to connect with me further. And stay tuned because I have many, many more master classes. Come peace.