← The Hunter Williams Podcast
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Lowe's Store Associate
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- [01:00]
Hunter Williams
Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today's video is going to be the CJC 1295 masterclass. In this masterclass, I'm actually going to cover both the no DAC version and the DAC version of cjc. So we're going to get a clear distinction of what those do. But looking at cjc, I think it's a great peptide. It's obviously in the G H RH class of growth hormone peptides out there for us. Um, I think this is one of those ones. It's probably one of the more consumed peptides, at least in the research space. It does some pretty cool things. But I think people don't understand some of the side effects and how those can play out negatively in a quite substantial amount of people. I would say not everyone, but some people just don't do well, well with the side effects. I think that's. This is one of those peptides. If I have kind of a pulse on the market of it, it's one of those that a lot of people will just buy because their friend told them to or their family member told them to. And it can work well, but they don't realize how powerful it can be. A lot of times it gets combined with ipamorelin and it can work really well with that. We'll cover that today. But as always, say I like to start all of these growth hormone peptides whether it's Tessa, ipa, cjc, even Sarah Morellin. I like to start them in isolation and see how you respond to them. Because the GHRH peptides seem to have a little bit of a more um, kind of like allergic induced reactions or mcast reactions. And so we'll cover all of that today. I love cjc. It's very powerful. It can do a lot for sleep, body composition and everything. But I think it's one of those that people probably more just buy because someone told them to and they don't really have a good understanding as to what's really going on with it, why it's so powerful and what some of these side effects are. And we're going to cover all that today. As always, thank you guys so much for being here. I've gotten really good feedback on the master classes, so. So thank you so much. I love doing these and putting these together and filming them for you guys. So just make sure as far as being in contact with me that you're on the email list because censorship does seem to be. Seems like we're in another little wave of censorship with everything. And then also too, if you would like to work more directly with me inside my private group, that's the Axion Collective, you can check that out on the links link down below. And then also too, you can check out my AI tool which will be in the link down below too. Lots of people using that, getting really good feedback on that. Just because people can use that to search and query my content, you can use it as kind of a pseudo peptide calculator. You can use it for a lot of stuff. I've been getting really good feedback on that. So without further ado, we're going to jump in today and cover cjc. This is going to be the CJC masterclass. And let's get into it. All right, let's get into it. We're going to cover the CJC 1295 masterclass today. There's two forms of this. We're going to go over those and I'm not going to tell you which one to use hopefully by the end of this. But you have a good understanding of which one probably works best for you because I know there's some confusion around that as well. Let's first look at something called growth hormone releasing hormone. When we look at Tessarellin or CJC or Sermorelin, what we are looking at are these GHRH analogs, meaning that they are basically built to be similar to Growth hormone releasing hormone and work in the same way. Let's cover that first so we understand kind of what CJC is doing and why it's different than GHRH itself. Basically our hypothalamus produces growth hormone releasing hormone, which then tracks, travels from the hypothalamus to the pituitary and then triggers a GH release from the pituitary. Basically the natural GHRH that's in the body is 44amino acids, but only the first 29 are actually needed for this signal. However, the problem with natural GHRH and you can even get a peptide called ghrh. I don't even know if many people sell that anymore. It was something that was sold years ago. There's probably some people around making and selling it now. But uh, the problem with that is that we have this enzyme called DPP Dash IV, some people call that DPP4 I think. And then basically that enzyme destroys natural GHRH within minutes, meaning that GHRH itself has only have a half life, about 10 minutes. And basically what scientists did, we'll cover the, the history a little bit, but they took that and then they modified it into CJC 1295 by targeting four different amino acid swaps. And you can see in this little diagram here, Basically with natural GHRH we have a rapid DPP IV cleavage which basically inactivates the peptide in around 10 minutes after it's produced. Basically CJC had four amino acid swaps at the end terminals which extended the half life and then is able to confer more of those benefits because it hangs around for a little bit longer. And so that's how we kind of arrive from GHRH into cjc. Similar things are done with Tessamorelin and serumorelin and other GHRHs. Now let's look at this DAC versus no DAC. When we have the, the phrase DAC, what that means is drug affinity complex. So DAX stands for drug affinity complex. And we have two versions of cjc. We have CJC without dac, which I would say is probably the, the better one to use. And then we, we have CJC with dac. Now when we look at those, CJC without DAC has about a 30 minute half life, which means we get one short pulse. You'll also probably see this called different places mod grf 129 or 1 through 29, hence the 1 through 29amino acids. And then we have CJC with DAC which has a five to nine day half life. And basically we get elevated GH for a week. And the way it is done through this is that bonds to something called albumin or an albumin binder that extends the half life of it and then can raise GH for a week. Now here, here is just. I'm going to take an aside for a minute to kind of explain this and hopefully this, this makes sense. And I'm not trying to tell you one way or the other. I'm just telling you my philosophy around this. When we look at things like albumin binders specifically for things like a growth hormone releasing hormone peptide or analog that is elevating growth hormone. To me, the, the beauty of growth hormone peptides or growth hormone itself is that it works in a pulsatile fashion. Meaning that for instance, when I take CJCC without that, I'm going to get this short pulse of GH which is then going to come back down and then I'm going to get this cascade of effects which we'll, we'll talk about, which come from raises in IGF1. But I'm not chronically elevating growth hormone. And this would be another master class in and of itself. I've talked about this in my private group. But basically the body can kind of exist in a growth state or it can resist or exist in an autophagy state. Meaning that we're kind of like in rest and digest mode. This would be like things like fasting or relaxing. And then we have MTOR mode or growth mode where we're trying to grow muscle. Now think about this. If you elevate growth hormone chronically without it coming back down, eventually, what that means is that you are signaling to the body to constantly grow. And while that can be good in short pulsatile fashion, when you're signaling chronic growth, what does that mean can happen? Well, the first thing you're going to see is insulin resistance. And then if you were to take it to the extreme, and I'm not saying you would do this from taking CJC with dac, but if you're taking it to the extreme and you did it for several years and you did it chronically and you were stimulating growth in the body via whatever mechanism, in this case, we're talking growth hormone, if you were to do that chronically for a long period of time, eventually you might run into organ growth issues, you might run into lipid issues, you might run into vascular toxicity. And so when we think about things that we're extending the half Life of we can look to retatrutide. Retatrutide or trirzepatide, they have half life of six to seven days. Retrude and terzepotide exists more on the autophagy side of things because they are releasing or they're increasing GLP hormone, they are working to reduce blood sugar. They are actually anti growth agents. They are more catabolic agents in nature than they are anabolic agents in nature. I'm not going to say taking trap causes muscle loss directly, although we know that that's a side effect for people that don't do things right. And so when we look at things that have a longer half life, I would rather see something that exists on the autophagy side of the thing side of the spectrum to have a longer half life. Because what that means is I'm going to get some of the benefits of fasting caloric restriction, which I know are good for longevity long term. Now, does that mean that we want to be on all the time? I think that's, that's yet to be determined. It depends on the agent itself. But when we look at things that chronically stimulate growth at a high level, I don't think it's the best thing to always do that. Whereas if we do growth hormone, whatever the, the means is in a pulsatile fashion, it goes up, it comes down, we get the good effects. And we can do that every day or five days on two days off. And we don't have chronic elevated growth hormone levels throughout the week. Yes, IGF will be slightly elevated or more in that therapeutic range, but we're not constantly signaling to the body to grow. And so that's where I kind of land on those things. And hopefully henceforth in the presentation you'll understand. Okay, if I, if I want D, maybe that's something you actually want. Maybe you are severely underweight and you actually need your growth hormone higher. Maybe you have pituitary dysfunction and you need growth hormone higher because you don't have kind of like in children, they have growth hormone deficiency. You actually might want that in some of those cases. There's actually a new version of growth hormone called in Jinla from Pfizer. And it basically is kind of where they only have to take growth hormone once a week because it's one shot and it chronically elevates growth hormone levels. And so I don't, I don't know specifically that much about Ingenla, but when I look at CJC with dac, some of the bad side Effects of chronically elevated growth hormone are water retention, insulin resistance, just feeling bloated and puffy. And I know I don't want that. Whereas if I post growth hormone I get the, the body recomp, effects, the muscle growth, the fat loss, but I don't have any of those side effects that would come from chronically elevated. And I know that's a little bit long winded but I just want people to understand that and understand when we talk about extending the half life for things in some cases can be very good but in other cases it might not be the best thing if we are talking about chronically stimulating growth uh, because there can be side effects that this point we just don't really know about that. Now let's, let's rewind a little bit and talk about the, the story which is pretty cool. Basically in 1982 two independent groups isolated growth hormone releasing factor from actually a pancreatic tumor. And there's a guy named Roger Guillamine and his group with John Rivier and Michael Thorner. They also turned GHRH from basically theory into a defined molecule with a real clinical picture from this pancreatic tumor. Then seven years later Lawrence from it identified DPP IV as the enzyme destroying GHRH and showed a single chemical modification at position 2 blocks the cut entirely. And basically every GHR G, H R H analog built sense cares that modification. And again we see this in Samurlin cjc Tess are the, the big ones that we all know about. And so basically from 1997 Cermorellon got approved by the FDA for children with GH deficiency which was the first GHR RH analog. 2005 we had CJC bound to albumin and elevating GH for days and rats. And then that eventually led to the development of CJC. In 2006 we had the first foundational human trials that confirmed pulsatility is preserved. And then 2006 we had a phase two trial halted after a P participant death with CJC. Now I will tell you this. When that participant died from taking tjc, what they were doing is they were looking at CJC as a agent to help people with HIV lipodystrophy which basically means that HIV and I think in this case aids. And what happens with that is they get a fat buildup. You guys probably know this is where Tessellin came from. They're actually looking at CJC to be something similar to Tessa Morellin. Now a lot of these people had heart disease and while a guy was using tjc, he actually had a heart attack and died. And they couldn't prove that it was from the CJC because he already had heart disease. He already had AIDS and lipodystrophy. But they said, okay, we don't want this being something that ends up causing any more issues with that. And that's why it got stopped. Again, it's very hard to prove one way or the other where it came from. But I just want people to understand that you'll hear that in the. The mythical lore of cjc, like, oh, CJC can't be approved. There's someone that took, that died. And as much as I'm not someone that tells, like, at. At the end of the day, I'm gonna tell everyone to take growth hormone. That's gonna be the, the path that everyone goes down. At some point in your life, at some point. Not saying you can't do the peptides or the. Even the peptides can't be very useful in a lot of cases. But I just want people to understand that, looking at the GH system, I want you to understand kind of mechanistically what's going on here. Again, basically, the hypothalamus sends the GHRH accelerator into somatostatin break, and then on the pituitary somatrops, they release stored growth hormone impulses. So we have that all going on in the brain. And then eventually what happens is that growth hormone goes into the liver, and then the liver produces IGF1. And then that feedback or that feeds back into the inhibited release of extra growth hormone. Basically, growth hormone is not released steadily. It comes in pulses, which are mostly during sleep. And again, we're not doing it again in. In between, which is why I like that pulsatile faction of whatever we're using to increase growth hormone. But basically, those gaps let receptors reset and keep IGF1 from staying elevated around the clock, which, again, is not what we want. And then again, think of this as a lighthouse. The darkness between sweeps is part of the design. You want it very focused in pulses rather than just being all around. Then we look at cjc. Basically, CJC is going to bind to the GHR receptor on the pituitary somatrops. And then what happens when that that happens is it raises cylic amp, known as camp, which activates something called protein kinase A. And then this switches on GH gene expression and releases stored GH packets. And then this release GH gets in the Bloodstream goes down to the liver, and then the the liver produces IGF1. And then IGF1 is what carries out most of the downstream effects like tissue repair, protein synthesis, and body recomposition changes. That's how it works. Very simple terms. That's how all the GHRH works. I'm not gonna go into the GHRPs, which would be like an ipamorelin or an MK677. Those are a little bit different, but that's what GHRHs are doing. When we look at those four amino acids which make CJC different from endogenous GHRH, we have the D alanine at position two. This blocks the D DPP Ib from recognizing the cut site, which is the most critical change without the molecules destroyed in minutes like we talked about. We also have glutamine at position 8, which re replaces asparagine, which degrades in the solution, improves stability in the bio and in the body. Then we have alanine at position 15, which changes the molecule's 3D shape to better fit the receptor, which increases the potency of CJC. And then the fourth one, we have Leucine at position 27, which replaces the natural methionine that's there, which oxidizes and the loose leucine protects the molecule from air exposure. And again, all those things to make the molecule more stable in lyophilized powder. And once it gets into the body,
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Lowe's Store Associate
now it loaves faster. Quotes. Start at the Lowe's Pro desk. Got a material list handwritten on a stick, sticky note or saved as a photo.
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Perfect.
- [16:03]
Lowe's Store Associate
Bring it to us and get a quote in minutes. And if you don't see what you need on the shelf, we'll help you get it. You can access thousands of products beyond what's available in store or on lowe's.com right from the Lowe's Pro desk. Build quotes faster and source the materials you need to keep your jobs moving. Just like that at Lowe's.
- [16:24]
7-Eleven Commercial Voice
When your 7 11's hot as fire chicken sandwich. People think you're intense. Well, yeah, I'm hot, so, yeah, intense. See if you can handle the heat. Then try me with pickles or spicy mayo and jalapenos. Oh, and it's all just $4.99. That's a deal. Almost as hot as I am.
- [16:42]
Hunter Williams
Almost.
- [16:44]
7-Eleven Commercial Voice
Sweets? No, Spicy. See for yourself. $4.99 and only at 7:11. Followed through 82546 participating stores only while supplies last visit store for full terms.
- [16:55]
Hunter Williams
Again, the DAC leaker I kind of went into this. But basically the drug affinity complex adds a 30th amino acid, which is a lysine, curing a malamide group. And that bond permanent bonds permanently to album's free sulfur at Site 34. And then the album circulates for around 19 days, carrying the peptide along for the ride. Basically the FDA flag. The malamide can bond to other proteins beyond albumin. Whether this happens or what it means has never been studied. But an open question specific to the DAC form, again, just another unknown that we we don't know. Around the DAC form, let's talk about this idea of GH bleed. Basically, the DAC version raises the floor without flattening. The peaks and pulses still happen, but the body now sits in measurably elevated GH continuous including hours when your own physiology would keep it near zero. Again, which is not always we want basically, practitioners call this the race for the GH bleed. And whether it matters over years, we don't really know. Again, it's one of those things. We do know that the pulsatile nature is much more congruent with what the body naturally does. We do know that the body does not chronically elevate gh. And when you talk about chronically elevating growth signals, it's one of those things we just don't know. Basically there was a study where they looked at uh, one dose of the DAC version and 12 healthy men. Basically their pulse frequency preserved. Was preserved, meaning that her body kept naturally making it. So unlike using growth hormone, their body didn't shut down. Uh, the mean GH rose 46%. They also had the, the Amplitude Pulse Reserve preserved IGF actually rose 44%, which again is not, not nothing, but it's not a lot either. Um, and then you see there the, the hormones trough and the trough levels rose around seven and a half fold, meaning if their baseline went up way higher. And again, that's just where we don't really know now how CJC differs from some of the similar compounds that are also GHRHs. When we look at CJC versus Serlin, it's the same backbone, but Samorellon lacks the four stabilizing substitutions and basically CJC. No, DAC is essentially the upgraded version of serum relin, which is why again, for the cost of what it is, I would just tell people to take CJC versus Sermorellon. We look at Tessellin. Obviously it's FDA approved with phase three trial data. And again, this is the one that you could get through a compounding pharmacy and has real tangible data where CJC doesn't really have a lot of human data. When we look at growth hormone, obviously when you inject growth hormone, it bypasses the pituitary and suppresses our own production. CJC works via the pituitary, which could be good or bad, depending on how you look at it. Because sometimes when people get over 50 or 60 years old, sometimes the pituitary is just not gonna signal as good as it was when it was in his 30s. And then we look at the GHRP side of things like ipamorelin. Those hit a completely different receptor, which is the ghrelin receptor through a calcium pathway. And activating both together produces more GH than either of those do alone. And so we do have a synergy there when we do that. We'll talk about that in a minute. Moving on to the use cases of cjc, let's look at who benefits most. I think obviously, like anyone can benefit from increasing growth hormone, but I think these are the ones that make the most sense of like, why I would use CJC. I think for people between ages 35 and 55 with declining recovery, GH pulse amplitude declines with age. And I think this is like the age group there. You'd still notice a good benefit. It's usually like after that age of 50, people start forking off into like, okay, growth hormone's gonna do a lot better for them than the, than the, the peptide itself. And again, the pituitary is still capable. It just fires less forcefully. So turning the signal back up fits our existing physiology. I think obviously athletes and hard training blocks that value recovery. It's very important. Elevated IGF is going to provide an anabolic background. And that's why people just do so much better when they're on some sort of growth hormone support. I think another use case is for injury and surgical recovery. If you are someone that has a soft tissue injury, you're using GLO or clo, bpc, Wolverine, you name it. It always behooves us to have a growth hormone player in the background, in my opinion, to help support that. Obviously you could use something like PEG MGF to help with localized IGF1 production, but for the purpose of increasing systemic IGF, which is only going to improve the healing process. I love that and I think CJC can be a good thing to do there and then for poor sleepers. GHRH analogs promote deep sleep, slow wave sleep independently of GH itself basically a bedtime dose, deep in sleep, noticeably, often within one to two weeks. And I think this is one of the main reasons people would use it. Especially if you're not ready to make the leap to growth hormone yet or you just can't source it for whatever reason. CJC works really well there and it's interesting because I always get asked about sleep. I just released the DIP masterclass last week. But even before all those sleep agents, I'm always like, growth hormone is the way. And so whether it's growth hormone, testament, cjc, whatever it is, can really benefit sleep. And that's usually the frontline defense that I have for people that are struggling sleeping, who should slip it one or who should skip it. Fundamentals not in place. If you have untreated low testosterone or thyroid dysfunction, GH peptides don't work. It's really sad. I've actually heard that more common lately and probably just because people can make money selling it. You do not replace testosterone with iParellin and CJC. That will never work. Is it better to take it if you're not taking anything? I mean, probably. But don't take something supporting growth hormone thinking it's going to fix your thyroid or thinking it's going to fix your testosterone levels. It's not going to happen, unfortunately. You are going to have to get on testosterone replacement therapy probably at some point. Blood work, just make sure that you're doing blood work again. It's not mandatory to do before, but I always just do that myself to have a good baseline of where I'm going. And then again, elevating IGF1 without training really will not build any muscle. Testosterone supplementation will. But if you're just raising IGF1 without testosterone, don't expect muscle growth or don't expect to not create the stimuli of training and then have that convert into muscle growth. It's not going to happen. Contraindications. I would just say active or recent cancer. Don't, don't really get into it. I just think it's one of those ones. Like is it. Can we definitively say yes or no? No, we can't. However, it's just one of those things. If you had an active or recent cancer, probably not the best idea to stimulate growth in those things. And again, I'm. I'm not telling you that it's dangerous because there's studies to show that growth hormone supplementation in people that have cancer in remission does not increase the re. Reoccurrence of Cancer. So we do have data for that. But I'm just telling you it's just one of those things. Make sure you're cancer free before you proceed with doing anything that would stimulate growth, pregnancy or breastfeeding. Obviously, we just don't know. I think under age 25, probably not gonna benefit a whole lot from it beyond what you're naturally producing unless you're deficient, obviously. And then also too with the DAC version, I would just say if you have diabetes or insulin resistance, probably not the best thing. Ironically, like I think some of the metabolic improvements from the nodec version could probably help people in those cases. But it's also too, you have to be very religious about monitoring because you can. For people that already have very elevated blood sugars or diabetes or pre diabetes, you could potentially exacerbate it. So again, just know that IGF1 promotes cell growth. If it's something that you are, had a, had a recent tumor or whatever, I would probably just avoid it until you're sure that is out of the way. Now, probably what you've all been waiting for is the flushing and histamine question. Now here's what we do know that around 70% of people are going to have injection site reactions from cjc. Now when I talk about injection site reactions, we're usually dealing with like 15 to 25% of people that have those. But in my experience this lines up with what I hear from people, including myself. Around 70% of people get these injection site reactions. Around 30% people get transient hives which is not really dose related that we can trace to. And then also around 63% get a headache versus 14% 18 on placebo. Those are the things to be advised if you are going to do cjc. And the reason I say is because people always run to CJC and IPA is like one of the first peptide blends that they do. Just understand that this comes with the territory, so don't freak out. Now sometimes if it gets into the point of causing anaphylactic shock, yes, you might have to go to the emergency room. Have I heard of that happening? Yes, I have. So be advised that that is something that's possible if you are someone with severe MCAs or severe, just more predisposed to having allergic reactions. But I just want people to be aware. Just like if I tell someone that's taking oxytocin, you are almost always going to get flushing and a headache from taking injectable oxytocin. Same thing with cjc. Let's talk about dosing. There's obviously no FDA approved dosing protocol. I will say when we look at dosing, there does seem to be a threshold dose, beyond which going higher doesn't really do us any more good. The first dose, which would be tier 1 general optimization. I like no DAC, 100 micrograms subcutaneously before bed, and then start here just to make sure. The reason I like starting a little bit lower than most people, because some people are like, oh, you take 300 micrograms is because of those side effects. And I would rather you have the bad side effects at 100 micrograms than 300 micrograms and then definitely more than like 500 micrograms. You don't want to do that. The first time. We move up to tier two, we have performance and stacking. This is where you could do a hundred micrograms twice daily. You do it before bed and then also pre or post training or first thing in the morning. You can also pair that with ipamorelin in a one to one ratio or a one to three ratio, depending on what you want to do. I've done all of them. I think doing a one to one ratio is probably fine. It's going to get you the same results. And then tier three, significant dysfunction or recovery for an injury or something like that. You could do 100 to 200 micrograms, two to three times per day. And then if you wanted to, for whatever reason, I would. You could do DAC one to two milligrams weekly. And the reason I just put that in there is because I just wanted to give people a dose. If they're going to experiment with DAC, that's what you would do, 1 to 2 milligrams. And you could do it once a week or twice a week. And then this would be for post surgical stalled rehab or just documented decline. I think really beyond the, the 300 microgram dose, you don't see any more benefits. Taking 300 micrograms to me is the same as taking 600 micrograms. Beyond that, it just doesn't seem to work anymore. Again, you're not gonna get any more IGF one out of that. And by, by proxy, any more results. Dosing by purpose, Longevity. A hundred micrograms, five to seven nights a week, 12 to 16 weeks athletic performance, a hundred micrograms twice daily, plus IPinelin, 200, 300 micrograms at bedtime. You could obviously run this 12 to 16 weeks injury or post surgery. A hundred micrograms once or twice daily. Sleep quality, I think it does do better with IPAM for sleep. So I do a hundred micrograms with 100 to 300 micrograms of ipamorelin. Body comp, a hundred micrograms twice daily plus ipamorelin, same thing. A hundred micrograms twice daily. Twelve to 16 weeks. Usually you're gonna have to give it at least that long before you're really gonna start noticing the body composition changes and then skin and connective tissue. 100 micrograms before bed, and you could do that continuously for 16 weeks plus if you wanted to. Obviously you're probably gonna deal with some downregulation, but I think it, it can be something there. We look at DAC again, the standard protocol, 1 or 2 milligrams sub Q once weekly. Some practitioners split into two injections every three to four days. I would at least do that if you're going to, instead of doing it once a week. But it's just one of those ones. Because of the half life, you can't get away with injecting it less frequently. Let's talk about fasting, because this is obviously something, when we talk about these, it's very important. Fasting, I would say in this case. I'm not one to say this with all peptides. If fasting is not optionable, basically optional, basically elevated insulin blunts the pituitary response. I would say inject at least 60 minutes before or after food when you're doing that. And then 90 to 120 minutes is usually a better bet if you're gonna do that. I think timing wise, bedtime is the best single dose. Basically, you already hopefully are fasted for at least an hour or two. And you could take it at nighttime before bed. However, some people get very stimulated when they take it at night. So you could take it in the morning. There's nothing wrong with that. And also too sometimes if you wake up in the morning, you are definitely fasted, hopefully for at least eight hours. So maybe it does a little bit better in the morning if you are fasted overnight. And then you can wait, you know, another hour and a half after taking it before you have any calories. But the nighttime dose we do know lines up with the body's natural pulsatile rhythm. And then timeline of effects. Usually those days one through seven is where you have the flushing that tends to subside in most people. Weeks two to four, you see sleep improvement. Weeks four to eight, recovery gets better. And then usually weeks eight to 16 is when you'll start to notice, hopefully the body composition changes. And then beyond week 16, this is where you'll see the skin and connective tissue, if you're injured usually start to improve there. Now when we talk about cycling, I get asked all the time what's the best cycle? Is it 8 weeks, 16 weeks? Ultimately you gotta decide what's best for you. But we do know when it comes to the growth hormone peptides, we do tend to build up receptor desensitization more so than things like SS31. Now let's talk about why cycling one to preserve responsiveness. Basically sustained stimulation produces diminishing response over time through receptor downregulation, pituitary depletion and the feedback loop. That's why I also too like doing the five days on, two days off because we're getting like mini breaks within the cycle there. That kind of. It's not going to stop the desensitization, but it's going to preserve it a little bit longer. Also too limiting IGF1 exposure. We don't want that chronically elevated all the time. We want it in a good range, but we don't want it chronically elevated. And then also too to preserve the feedback loop. The value of a GHRH analog is that your regulatory system stays in the loop and running the accelerator continuously for years works against that. And that's why it's good to even if it's just like a four week break every 16 weeks to give yourself time off. Standard cycling patterns, 12 to 16 weeks on, four to six off is going to be the default. I do like that five days on, two days off to give us many breaks within the cycle. And then you could also do targeted short cycles if it's for a very specific reason. I think one of the biggest questions I don't want to tell you have the perfect answer is could you use IPA and CJC for 16 weeks and then go to test some relinquish? You definitely could. And I definitely think you're gonna respond better to Tessellin, even though it's a GHRH than CJC after you've done CJC for 16 weeks. But maybe sometimes you wanna give yourself a break or even if you wanna go back and forth with hgh. So there's, there's infinite amount of combinations you can do. But I do think the good thing when we look at these peptides is yes, they're stimulating the same way, but they're also different compounds. And so you do get a little bit of resensitization to them, even though it's still stimulating the same pathway. We look at off cycle, what to expect. Obviously sleep usually goes back down. What happens is when we come off of these, growth hormone goes back to normal. It doesn't completely shut down because again it's a peptide and it's not growth hormone itself. But typically what happens is you will see a carryover in the body, comp changes, but again, there's no crash or withdrawal. When we talk about the peptides, which is a nice advantage over them, we talk about sequencing with other peptides. I think of foundation signal and amplifier. Basically stage one, we want the hormone foundation, which is always gonna be testosterone, whether you're a man or woman. Thyroid sleep, protein training, lifestyle, obviously that's important. And then we have CJC alone. I like doing that by itself first to make sure you're gonna respond well to it. I always tell people, if you wanna do IPPA and cjc, do IPA first, make sure you do well and then stop ipa. Or you can keep doing IPA and then introduce CJC to make sure you respond okay and you're a good responder to it. And then that's what I have. Stage three, add IPA marlin on top of. And this is going to amplify the pulse from adding the CJC in first. And then if you wanted to, I like doing CJC alone first because it allows us to assess how the body is going to respond. Because again, I will say I don't think it's 70% of people, but probably 10 to 20% of people are just not going to do well with cjc and it's not going to be with you for you. And so that's why I like starting in isolation. You can do IPammerelin first by itself. You can do CJC first by itself. Just don't do them together by itself. And then once you assess your response to both of them by himself, then by all means add them together. I think if I were going to do one first, I would probably do ipamorelin first and then layer in the cjc. You could do the CJC first if you wanted to, but I always just like ipamrellin first because the, the negative effects are usually so few and far between compared to cjc.
- [32:48]
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- [33:17]
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- [33:35]
Hunter Williams
Almost.
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- [33:49]
Hunter Williams
Let's talk about some Reconstruction basics. Basically, CJC is very easy. Just use backwater, shoot it down the side of the vial, don't shake it really bad, even though that's probably a little overblown in terms of how careful you need to be. And then just make sure it's refrigerated. Nothing weird there with CJC to my knowledge. And then there's the, the reconstitution amounts. Easiest thing. Usually you have a 5 milligram bio. Add 2 mls of water and then 100 microgram dose is 4 units. That's the common default. Obviously you can do whatever you want. Use the peptide calculator, et cetera, et cetera. I usually do it subcutaneously. You don't need to do it intramuscularly, that I know for any reason. 29 to 31 gauge needle and then just rotate across the belly. You can also do the thigh, arms, wherever is good. And then just make sure you know you're stored in the fridge. Usually it's going to be very good in three to four weeks. You could probably do it after, but usually three to four weeks is going to be when it's the most potent. Also what to track. Obviously IGF1 is the best proxy that we have. It's not perfect, but it's, it's definitely better. Um, you could also just track sleep quality, energy recovery, training, capacity. Also photos, body measurements, blood work via IGF1 and then also too I think a really good thing with the growth hormone releasing hormones is a track HRV data, sleep data, all those things to see if that's improving. Let's talk a little bit more about the pairing with Ipamorelin. Again, basically they, they activate different receptors through different pathways and converge on the same pituitary cell, which produces more GH than either produces alone at any dose. Ipammelin was characterized in 1998 as the cleanest compound in its class. Has a potent GH release without raising cortisol, prolactum or reproductive hormones at up to 200 times the effective level. And again, that's why it's better than GHRP2 or GHRP6. Again, the ratio, you can start at a one to one ratio, which would be 100 micrograms of CGC and 100 micrograms of ipamorelin. If you moved any of those up, I would probably move the, the IPAM relin up to 300 micrograms. But you could do like 150 CJC, 150 ipamorelin. That's also a very standard dose to do also too. It can work well with BPC and TB500, especially for injuries. And then what I'm always going to say, I think if there's one pretty doggone good rule of thumb in the peptide world is if you're doing a gop, whether semators, retta, whatever, to use a GL or a GH peptide with it, they work so much better. Obviously testosterone is very important, but in terms of the muscle loss that people experience on GLPs, again, I'm not going to sit here and tell you that a GH peptide is going to accrue some crazy amount of muscle, but it will at least help stop the loss of lean mass so much. Probably, I would guess like 80% of the lean mass lost. And people that are not on a GH peptide on GLPs could be stopped by a GH peptide and then the rest could be stopped by testosterone, obviously. But again, also, 2 GLP is going to help with insulin sensitivity. And so if you did want to do the DAC version for any reason, I would be on a glp, I would be on metformin and I would be on an SGLT2 like Farsiga or Jardians. But I think it's, it's wonderful to pair GLPs with a GH peptide. Talk about some troubleshooting. One, I don't feel anything because that's obviously I always put this in the master classes. Cause it's usually like something I hear about every pep Dad, I took it and I don't feel it. One, your baseline could already be good and so you might be making GH and the, the extra increase from CJC might not be anything that's very possible. Also too you might not have given enough time. And so sometimes it's gonna take that 8 to 12 or 16 week mark. And also too timing can be a big thing. And that's a very real thing. With these compounds in the GH class. If you're not fasted, it can seriously impair the absorption and the effects created by it. Injection site reactions. You know, this is very common with CJC to get welts or hives around it. You could use some Benadryl to offset that. You could use topical Benadryl or oral Benadryl. Obviously flushing and histamine. You know, I would say if you are someone that has an experience with anaphylactic shock, keep an EpiPen on hand because I've seen that happen for people where they have to go to the hospital for this. You will probably get some sort of water retention. One to two pounds in weeks. One to two is expected, but usually it goes away. And that's also too why I like giving myself a break on the weekends. And then also to just make sure you're checking your blood sugar because probably gonna be okay. But it can happen in people that are borderline diabetic that you see it go up. Obviously too just quality product. CJC is not one that's fake that much. Is it legal? No, it cannot legally be compounded by US Pharmacy because it was put on that category two list. Will it get moved? I think that's one of the ones that's going to be evaluated in February. So we'll see what happens with that. I guess it's probably not because of that one death that has kind of marred it. So we'll see what happens when it comes to it. Obviously they voted on six out of the seven on the first meeting to least recommend to be decategorized. But we'll see what happens with the fda because again, even though those got voted yes, it doesn't mean that they actually were signed off on by the fda. It just means that the advisory committee recommended them to. So we'll see what happens. You know, still going to be probably another year before we really know what's going on there. Just answering some FAQs. Does it shut down my own GH production? No, it stays active. And so when you come off, there is no suppression whatsoever. DAC or no DAC, I would always say 99 of cases, no DAC is going to be much better. It's Kind of funny, I think actually. And I'm not throwing shade at all. But Brian Johnson did an experiment with CJC DAC and said it had all these bad side effects. And that's kind of like, to me that's like banging your head against a brick wall and saying that you have a bruise. It was like, duh, like that's what's supposed to happen if you bang your head against a brick wall. Again, not throwing shade or whatever. I just thought that was interesting that he would have even used that because no one that knows anything about peptides would recommend that. Can you take it orally or sublingually? Not to my knowledge. However, I have seen the, the buccal mucosa strips. I've actually used some of those with CJC and they do work like I do sleep better with them. And I did notice, you know, some like increased muscle fullness from taking it. Will it show up on a drug test? Potentially it is banned, so just be careful with that. Is it safe long term? I think the no DAC version is very safe. The DAC version, yet to be determined. Can women use it? Yes, I would say, although 87% of the trials were males. I think women do really well with the IPA and CJC combination, whereas men tend to do better on Tess and Tessa and ipa. But women really love the IPA and cjc. Where's the field heading? I don't really see anything really changing with the ghrhs. And even we have Tessellin, which would be considered an enhanced version. Although I think for women, Tess can a lot of cases be too strong and so CJC might be better for them because TESS can cause water retention in a lot of women they don't like. And so I don't really think that it's one of those that we're gonna see too much more development in the future. I think if anything we'll probably see a migration towards doing oral capsule forms that kind of have the same effects. But again, cjc, it definitely is one of my favorite for body comp recovery and long term health span work. But it's also one that a meaningful percentage of people do not tolerate well. And that gets glossed over a lot of times in marketing material that you're going to see. Basically has a very clean mechanism, works great in tandem with our body's natural physiology. The flushing, the nausea, the Welton hives, the headache, those are very real. And again, it's a, it's a substantial amount of people experience that if I were gonna run one, I would run the no DAC version, cycle it at 12 to 16 weeks, give yourself at least, you know, four to six weeks off in between. Make sure you're testing IGF1, only add iParelin once you've established your tolerance for either of those in isolation. But if you do those things, you're gonna be good. And then basically we just covered today, the science, the evidence, the protocol, and then I'm always gonna be honest with you. It's not growth hormone. Growth hormone will always do better. But I still think it's a use case and there's still gonna be millions of people that it could be a very good solution for if they are looking to increase growth hormone. And that is it for the slides. And there you have it. That is my masterclass on CJC 1295. Hopefully it was helpful to you. I know a lot of you veterans in the peptide space probably knew a lot of this already, but I think it's good to know. I would say if anything I can close out with just because I'm very familiar with sales data in the peptide world. I would say there's anyone out there that has a really good pulse on what people are consuming, what they're using, it's me. Just because I see so many different stories of people in my coaching group and now my AI tool that aggregates a lot of that data. I would say that CJC is actually a peptide that a lot of people are buying, but not a lot of people understand the implications of some of the side effects for it. And although I think it can be amazing for all the things that we talked about today, just know what you're getting into. I, I hate when people just hear anecdotes from friends or family. I'm not saying that word of mouth is bad, but I hate when they hear your anecdotes and they just jump in without really knowing what's going on or what the peptide is doing. And then they have a bad reaction. They're like, oh my goodness, it's not for me. And then they end up swearing off a lot of the peptides and just saying that they're not for them because they don't understand what's going on. I think people are really smart and if you help them understand how they are going to end up being better, more educated users of the product, that will then help more people understand the product, which will then help more people get the health benefits that we're trying to, trying to espouse to the world from the products. And that's the One of the things that I just want to help with my material is not to tell someone what to do or what not to do, but just give them informed background on how to use the peptides and what to properly do, how to properly dose it and understand really what's going on there. So love to hear your feedback on this one in the comments. Let me know if this was helpful to you guys as always. In closing, thank you so much. I have so much gratitude in my heart for all of the amazing support out there and again whether you just like comment, subscribe, share this with friends and family. If you're in my private group, if you use my co, use my code of places that goes so far and helping me bring these messages to you guys and hopefully it makes your life better in some shape or form. So thank you guys. In closing, my heart overflows with gratitude each and every day I get to do this. It's dream come true. So thank you guys and I will see you in the next master class. Peace.