← The Hunter Williams Podcast
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You can hear it, feel it.
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I oh, let's go. Hey, everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today's video is going to be the Motsi Master Class. As with all the master classes, I'm really excited, but specifically for this one, I'm pretty pumped because I think Matzi is one of those ones. It is an incredibly useful peptide, and I think more or less is probably a little misunderstood in the marketplace in terms of what it does. Obviously, when it comes to the world of peptides, so many people are here for the fat loss, for the energy and those things, and Matzi helps a lot with those. But I think a lot of people kind of, they don't understand conceptually as much as what it's doing. So for the geek and nerd inside of me, I'm excited for this one today because hopefully for all you other fellow nerds and geeks out there, by the end of this masterclass, I think you're having a much better foundational understanding of what MATC is really doing. Obviously, I'm going to go into all the different protocols and stacking and things like that, but this one I'm probably more excited because I think it's understood and I think when we just think of MAT C now, people are like, oh, energy and fat loss, right? And while that is true, it's more indirect and there's a lot more under the hood that's going on with Matzi. So I'm really pumped for this one. As always, before I jump into the slides, thank you guys so much. I've been getting amazing responses from these masterclasses, so that warms my heart because I love doing these so much. It's good to know that people Also love consuming them. It does mean that usually my video output will be a little bit less because I'm doing longer ones. So it takes longer to prepare and, and film and edit and do all these. So I'm, I'm going down to one a week of these. We'll still do our live streams and then maybe I'll throw in a little 15 to 20 minute video if I really feel like ranting about something. But anyway, I love these. Good to know that these have been helpful to people. And what I like about these is they just kind of help build a library and encyclopedia of peptide information that is obviously not exclusive to me, but hopefully it helps in your research as well. But before I share the screen, as always, make sure you're on the email list. That's the best place to stay in touch with me and avoid censorship. And then also too, if you would like to join my private group, that's the Axion Collective. It's really cool. I think we've got over 260 or 270 members in there as of now. And so I'm really excited just for that group. And we do a lot of really cool coaching calls and live coaching calls and things like that in there. And it's a just, just group of really awesome people. And lastly, check out my AI chat tool. The last time I checked, I think there's like 8,000 or 9,000 active users on there. So that's pretty cool. And I've gotten really good feedback on that. And again, that's not like GROK or GPT or Claude or whatever really is just using my database of information to help answer questions that you may have. So very helpful there. And also helpful for me too, also to just fill in the gaps of content because it takes all of that data and then anonymizes it and then aggregates it for me to say, hey, a lot of people are asking about this. So anyway, without further ado, I'm gonna share my screen and today we are going to do the MATSI Masterclass. All right, let's get into it. Today's going to be the M Masterclass, the complete user's guide. This is an exercise mimetic peptide that actually is endogenous. So what we're going to cover today is the cellular mechanisms of MAT C, who is a good candidate for it, the dosing and cycling, obviously reconstitution, injection and then tracking and stacking and how to do that in the most optimal way. Let's just start with an overview of what MATI is. So it's a tiny peptide that our own mitochondria produce in response to exercise. Basically think the body exercises. Motsi is then produced by the mitochondria. Again, this is the only major peptide encoded inside the mitochondrial genome rather than the cell nucleus, which is pretty interesting. Think about this. When you train hard, your mitochondria release MOZZI as a chemical message telling the body to burn fat, take up glucose and build more mitochondria, also known as mitochondrial bio biogenesis. As you age, your levels fall. And taking it externally or exogenously attempts to restore signal in the body once made in abundance. And again, what I love about MAT C, a lot of the peptides we talk about are endogenous, a lot of them are not. But MAT C is already made by the body. And when you exercise, your body makes MI and then that signals all those things we talk about, which is pretty cool because as we age, the body becomes less efficient at producing MOT C. Thus we can supplement with it to get some of the effects that enhance it. Let's talk about where MOT C come from. Comes from. MOTSI stands for mitochondrial open reading frame of the 12s RNA seat. It is encoded in the 12s ribosomal RNA genome or gene of mitochondrial DNA. And the simply the C is simply a naming label. Almost every peptide in the body is built from instructions in the cell nucleus. Mitochondria carry their own small DNA loop. And for decades scientists thought it only coded for energy production proteins. However, Matzi proved the mitochondrial genome also includes S encodes signaling peptides that talk to the whole body. It was originally discovered in 2015 by colleagues at USC Southern California in a lab there. And it was the second mitochondrial derived peptide characterized in detail after humanin. Also need to work on the masterclass for human because humanin is another really cool peptide of mitochondrial origin as well. Let's look at Mitochondria 101. Basically the system that Matzi is acting on. When we have power plants, mitochondria convert food and oxygen into ATP adenosine triphosphate, which is the energy currency powering every muscle, contraction, neuron and heartbeat. And again, when we think about that, I know this is like an overblown analogy, but I want you to step back for a second and and understand how the body makes energy. We consume food and water and air and then that is converted into ATP. And when you think about that, that basically is the conversion process of those raw external building blocks into the energy that we then use to go about and live our daily lives. And again, when we look at mitochondria, they're they constantly read the cell's energy state during exercise or fasting. They signal scarcity and MOTSI is part of that scarcity signal. And obviously we have the age related decline. Mitochondrial function declines with age, so does MOT C. And those two factors are linked. And that link is the entire reason people are obviously interested in this peptide. Because we're replacing something that is very integral to this whole energy loop and circuit in the body, which is good for an energy of itself, but then it's also really good for other things like fat loss and helping with chronic disease and everything. The first thing we're going to talk about today is the AMPK switch. So you probably hear AMPK on all these podcasts and everything, but today I just want to give you an overview of what that is and then how important MAT C is for ampk. AMPK stands for AMP activated protein kinase. It is the master fuel gauge of the cell. Again, just think about the cell and energy and think about AMPK as the fuel gauge telling you how much or how little is in there. When energy runs low, AMPK switches on which then pulls glucose from the blood, burns fat and halts non essential building. It is the same switch, exercise flips and the same switch product or a drug like metformin flips. So when we think about ampk, we kind of have these two different sides of the spectrum. This would actually probably be a good video to go into. We have AMPK on the one side which is kind of like the fasting and exercise and, and then we have mtor, which is more of the growth, the rest and digest phase and we want both of those. However, MAT C exists on this AMPK side of things that is inducing a state of exercise and or fasting in the body. We have MAT C which blocks folate and then this thing called ICAR AICAR accumulates and then AMPK activates fat burning again. When we look at it, MAT C does not grab AMPK directly. It works one step upstream, but by blocking a spot in the folate cycle, which then causes I I CAR to accumulate, which then is a natural AMPK activator. Your own cells make their own switch flipper. And this is why MOTSI is called an exercise memetic because it's basically inducing this process in the body is taking place without having to actually exercise. Now we'll talk about this. You should exercise in addition to using MOT C, but you've probably heard of a product called Icarus. Honestly, I don't think it's something that is really worth taking in my experience. And even though we see that it exists along the spectrum of what MAT is doing, Matzy seems to be much more efficient for the ultimate outcomes that we're trying to create than I CAR actually is. Now, what sets Matzy apart, one, we have a rear dual action. Under metabolic stress, Mozzi does not stay in the cell body. It actually travels into the nucleus and directly binds to DNA inside the nucleus, switching on protective genes that control antioxidant defenses. And so most mitochondria to nucleus communication happens indirectly. And MOT C does it directly. And again, this is a peptide born in one genome traveling to another to edit the instructions being read there. And when we get into this, this is why I often will categorize MI as a software like program because it's doing all these signal things. Whereas peptide like SS31 is much more of a structural type peptide or has structural type actions. And again, this matters because the dual action, basically from flipping AMPK in the cell body and rewriting antioxidant gene activity and nucleus, is what separates MAT C from plain AMPK activators like Metformin, Herburine, or even a product like ATX 304, which I'm a huge fan of. The downstream effects, which is where this really comes in, is we basically get mitochondrial biogenesis via PGC1alpha activation. You've probably also heard of that. Another product like SLU P P 33 2. We also get reduced myostatining signaling, which eases the break on muscle growth for all the people looking for myostatin inhibitors. You probably didn't realize that MOT C is actually a myostatin inhibitor in and of itself. And then we also get this browning of white fat into calorie burning beige fat. And again, so we have white fat that moves into brown fat, which is then easier to to lose. Again, there's this whole white fat versus versus brown fat thing. That's why people love zoo cold plunges. But the end of the day we get this Beijing of fat, which makes it easier to get rid of this visceral fat. And so when we look at a diagram here, we have exercise triggers mitochondria to release Motsi. Or we could obviously inject it. Then moxy blocks the folate cycle, I CAR builds up, AMPK activates and then we get fat burning, glucose clearance, metabolic mitochondrial benefits and biogenesis. And then again we get this moxie enters the nucleus in that process and it activates antioxidant gene so it works as an antioxidant. Again, dual action AMPK activation, the cell body and antioxidant gene writing rewriting in the nucleus is what makes it so unique among peptides and why it is so powerful because we don't really have anything else like it at this point. Talking about similar compounds, look at, look at Mot C versus SS31. SS31 protects mitochondria you already have by stabilizing the inner membrane. Motsi builds new mitochondria and reprograms metabolism. One is protective and kind of deals on the structure and the other constructs and they are partners, not the same thing. And that's why they work so well together. We have MOT Cs and then GLPs which I think work really well together, although you want to use them intelligently. GLPs work in the brain and obviously to crush appetite, help accelerate fat loss. And Motsi works at the cellular level on metabolic machinery. And again, when we talk about GLPs a lot of times people think it's GLP receptor downregulation. It's actually much more energy deficit in the body that the GLP ca that causes the GLP to stop working. And when we look at MOT C we are actually kind of shifting that state back to being much, much more efficient at burning energy which can be synergistic with a glp. Then we have Mozzi versus Humanin. Both are mitochondrial derived peptides from the same genome. Huminin leads towards neuroprotection and cell survival and Mozzi is the metabolic and exercise 1. And again, as far as mitochondrial peptides go, Humanin has much more evidence around brain protection, specifically little bit of heart protection. SS31 kind of does both of those. But humanin seems to work better than the brain is also help seems to correlate higher humanin levels lead to less Alzheimer's and and we have MOT C versus that again I think and I'll talk about how we can use all of those together. Moving into the ideal candidate profiles. Why would someone use MAT C who is a good candidate for Motsi? First let's look at the metabolically stuck person over 40. This is typically that age of like 35 or 40 when a lot of processes in the body start to slow down, start to shut down. And so I think for those people that's probably, it's hard to track but probably where they're going to start to Notice more of an energy decline and I'm probably could be explained in somewhat or in some part by a decline in M C For these people who train consistently eat well and they still can't seem to get the results they got maybe when they were 25. It works really well. People with slow recovery, flat workouts and creeping fasting gluc glucose, maybe a little bit of pre diabetes or beginning stages of insulin resistance, it works really well and this is obviously probably someone whose natural mozzi levels have probably declined. Moving into people that are insulin resistant or pre diabetic if you have elevated fasting glucose rising A1C or high fasting insulin and again I look much more at that fasting insulin number than the A1C or the glucose although those are important and improving glucose uptake is Matzi's single most evidence supported benefit and it works really well in that case. Again obviously it's best as part of a broader diet and training plan probably in conjunction with glps but it works really well in in those cases with people that are insulin resistant or pre diabetic Obviously the aging athlete it works really well. People over 40 that are also engaging in athletic competition, it can really help. Mouse data on exercise capacity is strongest in older animals and in younger people we don't see as much of a performance benefit from matc whereas older people tend to notice it. And I've heard this anecdotally and again doesn't mean that young people can't benefit but I've heard anecdotally it's typically the older someone is especially if they are someone that's actively competing still kind of doing the athlete thing it seems to help there as well. Although just be aware MA is banned by most governing bodies for sport and then the longevity focused client pursuing health span rather than treating disease the goal would be to keep the metabolic machinery moving. Obviously we look at the concept of inflammation and aging inflammaging so to speak. This is one of the biggest upstream things we can do. If we affect at a cellular level all these processes is going to downstream have really really good effects for the long term. And that's why MOTC can be such a good tool here. Even if you're not using it for performance or you're not diabetic or pre diabetic or anything like that. It does make sense in my opinion to use at least a couple times per year should anyone skip it. Well, I'm going to talk about this today and I don't want people's panties to get into wine. I don't want people to think that I'm not a fan of Motsi. However, for the people that are very sensitive to peptide therapy that tend to have exist more on this MCAS/allergic response/hypersensitivity I tend to steer those people away from MOT C And the reason is in the last couple years I have just seen an explosion and people having bad reactions to it and I don't want to scare anyone away from it. However, it does seem to have a contingent of people maybe around 10% that just do not respond well to it and actually can have pretty nasty side effects. But when I tell people if you are someone that breaks out in hives or is more predispensed to or predisposed to have high allergic reactions to things, probably stay a while away. Obviously if you're a drug tested athlete it could show up on a drug test. I don't know how that works but I just say stay away. And then if you're pregnant trying to conceive a breastfeeding we just don't have any reproductive safety data. Although there is evidence to show that MOT C actually helps women. That not women but female mice because we're talking about research here but female mice that are aging, it actually seems to help prolong their reproductive years which is pretty interesting. Again, proceed with caution with active cancer. There's actually lab studies showing tumor suppressing effects of MOT C specifically around metabolically related cancers. But again we just don't know with peptides and going to be smart. I will say if you are on concurrent glucose lowering therapy I. E Metformin, insulin sulfon areas or GLP1 drugs monitor glucose closely and this is something that obviously I love this holy grail of glucose disposal type agents. We have GLPs, we have metformin and SGLT to inhibitors like Jardiance. I'm a big fan of using all of those things and I noticed that I am very sensitive to MOT C in how I respond from a blood sugar perspective. Now someone that is maybe less insulin sensitive or not as using as many of those other products they might not have an issue. But I have noticed for me the higher the dose I scale of MOT C typically the more I tend to exist in that hypoglycemia range where I have to be careful if I I don't have enough carbohydrates in order to help man manage my blood sugar and keep it, keep it higher. And then again for people with cardiac history or sensitivity to things of tachycardia. There are tons of anecdotal reports I've seen of palpitations and increased heart rate. It's kind of weird because over time Matzi seems to improve HRV and actually lower heart rate. But in the short term, especially if someone's never used it before, it actually will cause a higher heart rate in a lot of people, which makes sense. And you have to be careful that because you talk about using Retrue Tide with MOT C with some of these other agents, NAD plus things like that, sometimes you get a confluence of factors that maybe it's not one thing, but it's the combo of those things that can really drive heart rate higher. And again, just be advised. And that's why when we talk about dosing, I want to kind of walk you through what I think is the safest thing to do from dosing. But again, just the most important caution. I've seen severe allergic type reactions reported from tons of people and usually that comes at the higher doses. And this is why when we talk about dosing and get to that, I'm going to explain how I kind of walk into the dosing for MOT C. Speaking of which, let's talk about dosing. The first one I almost think of is like a screening dose for people. Again, there's no FDA approved dose. We don't really know Motsi. We're kind of just shooting from the hip. There's things that have been out there in the past and I will say I have moved away from what was probably common knowledge like 10 years ago and using Motsi to be on the lower end of dosing. Based on what I have seen just in the research public, the tier 1 dose is more of like a screening dose. And the reason I like to start here is for those people that are sensitive or just may think that they might have a bad reaction. Maybe you took CJC and had a bad reaction. Maybe you took Tesla and had a bad reaction. I'm not saying that you would have that with MAT C, however, I am saying I would start very low and work your way into it. And so the tier one dose are going to be 250 to 500 micrograms per day, subcutaneous for two weeks. And again, this is just a kind of a dose to make sure you respond okay. Because if you go and inject 10mg of Mot C the first day and your body is one of those that is going to respond negatively to it, I Would much rather have taken 250 micrograms and have a manageable response or allergic response than the 10 milligram dose, which could potentially be dangerous for you. And again, that's like kind of that screening dose. You're probably. If as long as you respond well, meaning you don't have an allergic reaction, you're probably. You're probably gonna be. Not notice anything at all. And that's okay. And that's why we start there for two weeks, because it introduces the body to the compound, gets it used to using it, and then you can walk your way into the performance and optimization dose, which would be tier two, to which I would say 1 to 2 milligrams per day, five days on, two days off. And again, to me, this is the workhorse range. I can take 1mg of MOTSI per day, five days on, two days off for eight weeks, get amazing results. I feel amazing. Works well. Everything on my blood work usually is super sound and does really well. And again, works great for metabolic optimization, improved exercise capacity and longevity. However, some people will say, well, that just doesn't do anything at all for me. I don't notice anything. For me personally, I notice a lot. So much so that I have to be careful if I'm resistance training that I don't go hypoglycemic during the resistance training workout. And again, it's one of those things like everyone's gonna respond differently. I would much rather you start at the slower dose, work your way into it, and if you do want to experiment with higher doses, by all means do that. I don't care what you do, and it doesn't matter to me, But I would rather have you respond well, work your way into those and then see how you do rather than just injecting 5 milligrams out of the gate and then having an allergic reaction and you end up in the hospital having to get an EpiPen administered. And then tier three is going to be much more of the chronic illness slash, significant dysfunction group, to which I would say probably if you're severely inflamed, severely insulin resistant, have lots of energy issues, chronic fatigue, things like that, I think these people can work their way in to, to this 2 to 5 milligram per day range. And again, some people go to 10 milligrams. I would really cap it at 5 milligrams per day. I would not do that. And again, this would probably be more of a couple times per week. I personally wouldn't do 5 milligrams a day, every single day. Although to each their own. That can work for some people. But I like this. Two to five milligrams per day for eight to 12 weeks under closer monitoring. And again, I think five milligrams is kind of the practical ceiling for native Motsi in real world use. It doesn't seem like least I've not seen in practice anyone getting more benefit from 10 milligrams versus 5 milligrams. For me, personally, I don't get any more benefit from 5mg than 1mg. But I know some people don't feel 1mg, so they work their way to 5mg and it feels great. And to them that works and that's really good. But again, I would just say work your way into this. And again, probably spend a month at those lower doses before you get into the higher dose. If you want to go there and see how you do and then kind of run it for a cycle there. But that's kind of my philosophy on dosing. I know there's the old, you know, 5 milligrams three times a week, Monday, Wednesday, Friday day. That works for you. Do that. But I would say work your way into it before you get there. Just a little bit of dosing by purpose for metabolic optimization or insulin resistance. I like 1-2mg a day, five days on, two days off for eight weeks. Pair with obviously a carb controlled diet. I'm not against carbs. I think MATI makes you use carbs better. But just be aware of what you're consuming. And then obviously check all your blood work for improved exercise capacity. Same exact dose for the same exact thing. You could do it pre workout for the exercise capacity. I would say if you want to do it pre workout, intramuscularly works well there. I'll talk a little bit about that in the injection technique section. General longevity and health span, same thing, one to two milligrams a day. Obviously. See, see a theme here. It's kind of standard dosing, but I did want to talk about these. Then we get to fatty liver support. Obviously, if someone is inflamed, has metabolic, fatty liver, things like that, I like that higher dose. But again, I would work my way into that. Talking about the small versus big dose protocols, let's look at small daily doses. If you do one to two milligrams a day, five days a week, what happens? One, you keep your levels steadier, you get better tolerance with fewer Side effects and it reaches the same outcomes for most people. Again, this is what I would recommend. By default, I have no problem. People want to do it. Conversely, we look at big infrequent doses. This could be 5-10mg twice weekly. It creates higher peaks that may mimic the natural exercise pulse of Motsi. However, we don't know if someone is going to respond bad to that. And again, just be careful for that. I like to inject once per day on dosing days and morning would be my time of choice. Again, it could be energizing. And you'd rather not have that effect at bedtime. I don't really know anyone that likes to take it at bedtime because it tends to have an energy producing or stimulating effect. Let's look at a timeline of what to expect. I would say weeks one to two, you might notice a subtle energy sift or slightly different relationships with hunger or nothing at all. Both can be normal. Some people don't notice anything. Some people are like, wow, this is amazing. Again, who knows what's happening? You could say maybe it's the end state of the mitochondria. We it could be how much mitochondria or how much mi, your mitochondria are naturally producing. We don't really know. Weeks 36. This is where you're gonna see more noticeable changes. Again, typically better stamina, faster recovery, steadier energy, and the sense that antigen is finally turning over. And for people that do feel it, I will say this is where things really start to kick in. And then us. Usually by week eight, the lab work should tend to catch up to what you're feeling. You'll probably see fasting glucose, fasting insulin and A1C start to improve there. On fatty liver, the human trial dropped liver enzymes meaningfully, but did not change actual liver fat on imaging. And again, the enzyme improvement likely reflects reduced inflammation, not specific flat clearance. And that's where something like retrutide would come in really. Well, I will say, I think that human trial, I'm quoting off a memory, was on the Mozzi analog. It was not on Mozzi itself. And so it's hard to say again with Mozzi because we don't really have data. Let's talk about cycling. And again, it comes to one of those things. If you really get into first principles, Socratic method type thinking, I love doing that. And it's kind of like why would, why would we cycle in the first place? Right? Well, here's the reasons that I feel it's probably appropriate to cycle. I'm not telling you what to do. But we look at it. No long term human safety data. And again cycling keeps total lifetime exposure modest. While we can catch up hopefully with more human studies again it can also show us whether the benefits are holding. And I think it's one of those things. A lot of times peptides specifically, specifically you see this kind of on the bioregulators. But a lot of times you can use them for a period but the effects carry on indefinitely or sometimes it's for months or years later. And I think when we look at MOT C, do we need to chronically be stimulating it or can we kind of use it to alter the environment in the body? To which maybe I use it two or three times per year. One, I don't have to spend a bunch of money to take it every day. And then also two, maybe I'm doing more, more, more benefit by cycling it because I'm kind of creating this environment in the body, letting it do what it does. And then assuming things start to return to the way they were pre using Mozy then I would go back to it. Then obviously it fits broader peptide protocols. I think for, for specifically Motsi, this is where it's cool because we can do different mitochondrial kind of things that we're addressing with mitochondrial health at different times to create different results that when you look over the course of a year, like hey, I actually reverse age myself because I did these specific protocols. And again, caution here is not about tolerance. There's no strong evidence of receptor desensitization. Is more about just being prudent and kind of being smart with what we are doing. From a practical perspective, I like eight weeks on, eight weeks off. That's the typical thing. And you would do that three to four times per year if you wanted to. You could do 12 weeks on with four to eight weeks off. You could also do four. Sometimes I'll do this just with four week specific targeted short cycles where I'll just like month to month go back from mat C to SS31, you can do that too. Or you can do eight weeks on, eight weeks off. And then sometimes people like to do continuous low dose. I'm not as much a fan of this with MOT C. However, I don't, I think there's worse things you could obviously do, right? And so if you do want to do that because it makes you feel better or you like the results, I wouldn't have a problem with that. I would just say probably the error on the side of doing the lower dose rather than the higher dose, what should we expect off cycle and for the long term? One, the acute effects usually gradually fade rather than crashing again. That's where I would say the moment you come off MOT C it's not gonna be like oh my goodness, I lost my month C now I have to worry it usually is going to be like a month time period that it would tend to diminish. But energy and workout capacity ease back towards your new baseline over a few weeks. And if you generally improved metabolic health through the combination of MASI training and diet, good chunk of that is going to hold for the long term. And again, it lives in the tissue, not just you taking the peptide exogenously. When we look at long term, the the longest published animal exposure run weeks to months with no cumulative toxicity signal. And again, there's no long term human data. The reassurance is that Motsi is a peptide our body already makes. And again, when we look at those endogenous peptides, although you could obviously overdo it with those, it seems to be pretty safe because it is something that our body knows how to use and knows how to use it. Again, doesn't mean it can't go wrong. But again, I feel a lot better in most cases with some of those endogenous peptides just because it's something the body recognizes when we are introducing it from an exogenous source. Let's talk about the pairing that everyone probably is here for Mozy and SS31. What to use, when to use, how to use it. Let's get into that. And obviously I probably talked, I, I know I talked a little bit about this on the SS31 masterclass. But basically picture mitochondrial health as a manufacturing operation. SS31 is the maintenance quality control specialist and Motsi is a construction crew and operations manager. Combined we have SS31 kind of in the background making sure everything works properly and then Matzy coming in and building new mitochondria and signaling to enhance what is going on from an antioxidant perspective. SS31 binds a cardio lipin in the inner mitochondrial membrane. It protects the existing energy production line from oxidative damage, basically stabilizing everything there. And then Mati comes in and builds new production lines through mitochondrial biogenesis and reprograms how the plant uses foolishness or uses fuel. And then think about that as scaling up mitochondrial health, which is pretty cool.
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how would we do it? There's a ton of different ways to do this. There is no right or wrong way to do it. I think at the end of the day, if you take both of them, you're probably going to be healthier than if you didn't take both of them. And again, you could get into the weeds of this. There is so much debate or confusion around this and I just want you to know you're probably okay whatever you're doing. If you're. You're taking these. Here's my best approach to it and what I think is best. But again, you don't have to do this. You can do whatever works for you. Here's one. For significant mitochondrial dysfunction, typically what I would do is weeks one to four I would use SS31 alone. Again, maybe that's one, two or five milligrams per day. And what that's going to do is going to stabilize existing mitochondria. Weeks 5 to 12 I would actually add MOT C at 1 to 2 milligrams per day, overlapping in addition to SS31 for at least four to eight weeks. And again, this is going to get protection and construction simultaneously. And then from there I would come off of SS31 and continue MOT C through its eight week block while tapering SS31 to maintenance. The reason I do this is because leading with Matzi on badly damaged mitochondria means ramping up production on a crumbling base. And we don't really want to do that. And that's why I like to lead with SS31 first. But if you're someone that's already healthy and you're just like, hey, I want to do something to address mitochondria, I feel good, but I want to just improve everything and kind of COVID all my bases. I like eight weeks of SS31 and then eight weeks of MOT C and you kind of just go back and forth, if you want to do MAT c first, by all means, go ahead. I think for people that are more healthy, probably matters less than if you are inflamed and had mitochondrial dysfunction. I would tend to. If someone's never done it before I would do the SS31 first. But again for me I'll do SS31, I'll do MATZI, I'll do SS31, I'LL do MAT C and I just go back and forth and then during any overlap both peptides stay at their standard standalone doses. They do not compete for the same target. And again there's no risk in. Or there's no risk in. In doing the same doses on top of each other. And then you could also rotate with human and this is what I've been kind of going to. So you would have SS31 human and MAT C SS31 human. However you wanted to structure it. And again, I think it's one of those things you could debate about what comes first but then when you start cycling them it's really like which one was first because you do human SS31 mot C. That would be the standard that I would take someone through if they've never done it before. But at any given time I'm using one of those. So it's really one of those things. It's like what was first or what was last doesn't really matter when it's in sequence and you can just kind of rotate every eight weeks between those things. And for me that seems to work really well. I will say I s. I tend to. To feel less from humanin than I do the other ones. But again it could be one of those things. My brain's probably pretty healthy at this point with everything that I do. And so there might not be any noticeable improvement from what I'm doing. Maybe there's something under the hood. But again, I think for people that are interested in neuroprotection for the long haul, for staving off dementia and things like that, it can work pretty well. Obviously reconstitution Mozzi is really easy. Comes lyophilized and freeze dried powder. You can use back water. There's no special water or anything you use most. Mozzi usually comes in 10 milligram vials. I do see some that come in 40 milligram vials if you want to get those. But typically what you're going to do is just add 2ml of water. Easiest thing 10mg vial. Add 2mls of water and you see there on the chart. So if you wanted a 1mg dose that would be 20 units. Very easy. If you wanted 500 micrograms that would be 10 units. If you wanted 5mg that would obviously be a whole entire ML based on that reconstitution. But super easy for that one. Nothing to worry about, no weird reconstitution issues or anything like that. There was always the debate over whether MAT C degrees in the first 15 minutes. It does not. We have now purity and analytical testing studies, studies to show that obviously reconstitution. Just make sure you're doing everything sterile. Shoot down the side of the bottle. Don't just shoot it straight down. But from what we can tell, M seems mozzy. Seems to be really good. 30 days, I think is the best practice for how long it lasts. But I have used Mati that has been well beyond 30 days and it still seemed to work for me. But I think when we look at purity or potency, probably within 30 days is the best thing. Again, injection subcutaneous is the easiest one. So you can do it in the fat layer under the skin. If you're doing the sub Q, you can do intramuscular. I will say here is where I would do intramuscular. If you want MOT C to hit faster, quicker and clear quicker, do intramuscular. If you want a slower effect over time, I would use sub Q. If it's your first time, I would do sub Q because if it's intramuscular, it's going to hit quicker and you might have some of those bad side effects quicker. For instance, the hypoglycemia. But notice I go more hypo when I do intramuscular MOT C if I'm doing it before a workout. I will say though, for people that do have mass cell reaction to things, you might benefit from doing it intramuscular instead of sub Q because there are less mass cells in the muscle tissue than there are in the fat tissue. And for someone that's sensitive, I would start with a low dose, maybe half a milligram and then you could do intramuscular. And a lot of times, not all the time, but a lot of times that seems to improve that allergic response. For people that are sensitive, again, you could do ab, outer thigh, back of upper arm, wherever. If I'm doing intramuscular, sometimes I'll do it my glute or my delt 2129 to 31 gauge needle again, 45 to 90 degree angle, depending on where it's at. Then just inject slowly and then again. Storage rules. That's easy. Just keep in the fridge once it's mixed. 30 days is best, but you could probably use it for longer and then travel again. Just make sure it's it's cooled down, no need to double up on the dosing if you miss a dose. It's fine looking, attracting, tracking. What do we track? Is there any actually thing that we could track? Well in this case, yes, we have subjective again, daytime energy, workout capacity, recover sleep quality, all those are important. We look at objective biomarkers. Fasting glucose, fasting insulin, Homa, IR, A1C, lipid panel, liver enzymes, CMP, comprehensive metabolic panel, those are all important performance metrics. You can monitor your hrb, resting heart rate, bot max, those would be the biggest things there. Then body comp. Obviously it's not going to be a direct fat loss peptide, but I would test it if you are trying to move your body fat percentage in the right direction. Talking about stacking, what pairs well SS31 in human, this is going to be again a foundational or foundational stack to the mitochondria. So we can rotate those in or stack them together if you want to. If I was going to stack 2 I would probably do SS31 and M together. GLPs work amazing. Reddit or Zepatide, they are very powerful and complimentary for body composition. Obviously the GLP reduces the intake, usually increases the metabolic rate a little bit. Matzi improves how cells handle what we eat. And again, just make sure that you're monitoring your glucose. If you tend to be on the more hypoglycemic side of things. Obviously growth hormone, growth hormone, secrete cogs work really well alongside those. You do get a little, little bit of myostatin inhibition out of those as well. And then TRT and hormone replacement obviously is gonna be one of the biggest things that's what will make MOT C work so much better is if your hormones are optimized. When we talk about stacking, please just be aware. Introduce one new compound at a time. And so if you're on a GLP and you're thinking about doing all these different things, maybe just add in Motsi in addition to it and make sure that your body adapts pretty well. Because what I have seen is a lot of people are doing 15 different things. They throw in mot C and sometimes Reddit, True Tide and Monsieur together can be so strong it's overwhelming to people. Also when we talk about am, am, P K if you are taking metformin or berberine, it's it does activate the same AMPK switch that MOT C does. So combining them can be redundant or push blood sugar lower than intended. Most practitioners prefer one or the other. I do take metformin, just 500 milligrams of metformin when I'm on mozy. But I think with all these new things I'm. I'm shifting my opinion. I think Metformin is becoming much less relevant. Maybe it's still necessary, maybe not. But I think it's much less relevant when we do have things like M C. Let's go into some troubleshooting for people that might not be getting the results they want. The first one is usually I don't feel anything. This is kind of with every peptide. But Motsi, I do hear this a good bit. Again, your baseline may already be good. For young, lean and metabolically healthy people, MOT C has little to fix there. And again, however they may feel might not be the same again, doesn't mean that a young person can't benefit. If they are fat and inflamed, they're probably going to have lower MOT C levels. Again, the dose may be too low. So if you're still in that screening dose window, work your way up to the one to two milligram range. And again, even then you might not feel it. But I would rather you do that than jump straight to the high doses. Again, you might not have just given enough time. It's more of a cumulative thing. And so if you're doing it every day for period of time, you're going to see results over time. Again, just check your product grade. Again, I don't think Motsi is one that is faked very often. And then again, Motsi can't fix what it doesn't address. So fatigue from poor sleep, thyroid issues, low testosterone or nutrient deficiency are not going to be improved by using MOT C. So we always have to go back to the fundamentals. We look at side effects. The most common hands down is injection site reactions. You get localized redness, mild discomfort or small painless lumps. Minimize this by rotating sites daily in injecting slowly and ensuring the peptide is fully dissolved at room temperature before injecting. Sometimes taking out of the fridge and letting it sit for a little while can help. Again, during the early stages, you might get a mild headache or transient fatigue. In the one to one to two weeks as AMPK comes online, it usually settles. Also make sure you stay hydrated. I have talked to a lot of people recently, last year or so, they get really tired from MOT C. Probably is because of an electrolyte imbalance. And then also too we're getting this metabolic shift change in the body which is Very tiring and very taxing on the body. Again, low blood sugar. Just be aware of that. I've, I've hinted at that, but just make sure that you have carbohydrates around because that could be something that happens if you're on MOT C. If you do get a severe allergic reaction, I would stop immediately. You could get hive spreading across the whole body, swelling the lips, tongue, throat. Again, stop the peptide. And a lot of cases you might have to go to the emergency room. I don't say that to scare people, but I've just heard that happening more than once, I'll say. So just be aware of that. And again, if you get a severe allergic reaction, persistent injection site infection, repeated symptomatic low blood sugar, persistent heart palpitations or racing heart and then no benefit after full 8 week trial. There's nothing wrong in skipping MOTs C. I don't think it's one that you necessarily have to have. Again, it. There's so many other great peptides out there. If you're someone that just doesn't do well with it. Again, there's other things that you can take to still get really good effect. Let's go into some faq. Is MOTC legal? No. Oh well, excuse me. It is legal. It is not FDA approved. It's obviously sold for research purposes. That's the best way to get. It does look like it's Moving from Category 2 to Category 1, which means compounding pharmacies will now be able to make it hopefully in the, in the, in the future. It is banned by wada. So again, be aware of that. If you are in a sport or a drug tested sport. If you are getting drug tested, how much weight will you lose? It's really hard to say. It's not directly correlated with the dose of a GLP to weight loss or like a GLP is. It obviously improves how cells handle glucose and fuel. It supports fat loss when combined with diet and training, but does not crush appetite at all. People chasing dramatic scale changes from MOTSI alone are usually disappointed and they definitely think you could use it in an off cycle of a glp. But unfortunately it's just not gonna do the fat loss by itself that some of the other peptides will do. Can you take it orally as a, or as a nasal spray? No, not that I've seen. I know people will try to sell it, but it doesn't appear right now that it works well. So again, this one is strictly going to be an injection. Does it break a Fast or kick you out of ketosis? No, it has no calories, it does not raise insulin. If anything it lowers it and by activating mpk, it actually pushes the cell towards the same fat burning state that fasting and ketosis produce. So it actually be kind of an inducer of fasting and ketosis rather than an inhibitor. Can women take it? Obviously yes, women can take it. I don't think there's any dosing differences poor for different sexes. But there are peptides out there that, that you would say that probably. But for women, I think it's the same dose. Is it safe with cancer history? Obviously we have data to show that it suppresses cancers, but again, we just don't really know. Can you take it with metformin and berberine? I would be careful, I personally do. But just be careful with it because if you are more insulin sensitive, that could cause you to go hypoglycemic. And again, we have this 15 minute myth is, is it degrading within 15 minutes of mixing? There is substantial data to show now that that is not the case. And, and again, because a lot of people confuse the short half life in the bloodstream with stability in the vial. Reconstituted moxie is good for at least 30 days when it is refrigerated. Again, just because something has a short half life does not mean that it's still not having signaling changes well after the drug clears. So just remember that if it's only in your system for a few minutes, that's totally fine. But we're still getting a effect over time, especially when we're doing a cumulative dose over time. Will it help with long clo, long Covid or chronic fatigue? We don't have clinical trials, but it does seem to help a lot of people. I've seen anecdotal suggest. Anecdotal data suggest that. Does it reduce liver fat? There was in the analog, I believe 21% drop in liver enzymes, 28, 21% in ALT, 28% in AST. But actual liver fat on imaging did not change versus placebo. And again, this is likely from mozzy improving the metabolic state in the body, not actually directly removing liver fat like retrutide would. And again, Cobar's CB4211, which is the analog, it finished a phase one trial in 2021 was safe, no serious adverse signals. But eventually they were not able to bring it to market. And so it kind of just sits where it's at. Where's the science heading? We see a lot of these animal models suggesting pretty cool things aside from the metabolic benefits we Talked about today. 1 Lung protection. Recent work shows MO protects against lung ischemia, reperfusion injury and radiation induced lung damage via nuclear antioxidant gene activation bone metabolism. We actually see a group studying mat's role in bone metabolism and osteogenic differentiation to prevent osteoporosis, which would make sense when we look at some of those mechanisms we talked about. Even if it's just myostatin inhibition and then cancer biology, early signals are tumor suppressive in ovarian and liver cancel models. Again, and this is just in rota models, not human. Human models. Where do we go from here? There have been stabilized MAT C analogs. Unfortunately they weren't brought to market. Will it give to FDA approved? Probably not, but hopefully the I think the best hope is we get it moved from category 2 to category 1 other exercise memetic drugs. I think for people that don't tolerate Motsi well. S o u p p332 we're getting a lot of the benefits, although completely different mechanism, a lot of the benefits of Motsi in an oral format or a transdermal format. Again, it's a small molecule activating estrogen related receptors to mimic aerobic exercise effects. Again, it's not a Mozzi analog, it's not even a peptide, but it still kind of works on the same things and it's obviously still preclinical. And again, when we look at human evidence, we're probably not gonna get it. And so this is probably gonna be one of those things in the research world. And again, I think the best thing we can hope for is that it becomes something that people or clinics can use because compounded pharmacies can now make it. Just to sum up, dosing 250 to 500 micrograms on the screening dose, 1 to 2 milligrams tends to be the best therapeutic range. And then 5 milligrams for me would be the practical ceiling. And then the standard cycle was about eight weeks. Just to sum up there, who gets the most out of mat? C. So what can you do to make it work best? People that usually are doing everything right, but you're still not getting the results you want, usually going to respond really well. If you are young, lean and already metabolic healthy, you might not need Motsi or you might not notice anything from taking it. And then again it's an amplifier. So Matzi works best as a multiplier on top of solid fundamentals. Training, nutrition, hormones, sleep. It amplifies those signals and it will work best when we are doing all those other things. It is not unfortunately a replacement for exercise, although it would probably be better if you're not going to exercise to take it than not take it. It will not replace exercise and it will work better when you use it. If I could give you one thing to take away about MOT C start low, go cycle, go slow, cycle it and respect it. Because this is not a peptide that not a peptide to be trifled with. It is one that is very powerful. I love it, but I do want people to understand it is a powerful peptide.
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Again, Matzi is more bioactive than its reputation suggests. It is closer in seriousness to a metabolic drug than to a casual gym. Add on Very, very important to understand that this is not just like a pre workout that you would just take from gnc. It is very powerful and it can have bad reactions some people. And again, I don't say that to scare anyone. Don't fear mat C but just understand that that's important to know if you're getting into this and have not used it before to understand how your body's going to react to it. And again, when it comes to evidence, everything looks really good but we just don't know yet. We don't know what we don't know. And there's always things that I always say, you know, to quote the notorious Donald Rumfeld, we have unknown unknowns and when we look at these things we just want to be smart about what we're doing and respect these compounds because they're a lot of cases more powerful than we probably realize. Again, I would say Motsi is a tool that reward that rewards respect. Again, use it with respect and it will get good results for you. But I would say don't use this just willy nilly. It's not like a KPV that you can just inject and pretty much nothing bad can go wrong, right? Like you can inject as much KPV you want. It's like okay, not really going to do anything and so it just. It's a powerful peptide. It works really well. But just make sure that. That you're. You're taking it seriously. Because a lot of people, I will say out there, they're just throwing in Mozzie with Retrutide and some other stimulants and stuff, and it's not always the best thing to do. And sometimes people get these increases in heart rate, and it can be scary for people. You know, they just go buy stuff that their friend told them to take. You know, like, they're like, hey, just take Retrue, Tide, MOT C and cjc. And then before they know it, their. Their heart rate's to the roof, they know what's going wrong, and they might have an allergic reaction. So again, just be advised. I love Motsi, but you do need to treat it with respect. And that is it for the slides. And that is my masterclass presentation on Mozzie. Hopefully I covered everything. I did my best job to cover as much ground as I could and to go over a lot of the issues I see in the space. Now that we have closed the loop, hopefully you understand now Motsi is much more than just a fat loss. Peptide is doing a lot to signal things at a cellular level that will improve our health through the long term. I am a huge fan of Motsi. I love using it, but again, like I said, it's one of those things. We got to respect it, we got to use it for what it is, and we got to understand how powerful of a tool it is. I look forward to your feedback on this one. I'd love to hear the comments and your results with MOT C. So drop those below. And just in closing, as always, thank you guys so much for the amazing support. It's so cool to see all the people coming to the Peptide space and all the people hopefully finding my information, all the other great people that put out information out there to really take control and have sovereignty over their own health. I think Matzi is a very powerful tool that lets us do that, obviously. But thank you guys so much. Just in closing, as always, whatever shape, form or fashion is that you support me, whether you use my code at places like Comment, subscribe, share this with friends and family, or even if you're in my private group and things like that, thank you guys so much. You don't know how far that goes and helping me bring these messages to you. So as long as you guys are still there, I always say, without you guys, I don't exist as long as you guys are still there. I will keep doing this. But that's it for this one. I look forward to your feedback. Many more master classes to come. Stay tuned and I'll see you in the next one. Peace.