Reader Mailbag 4 — Peptide Overdoses, GLP-1 Anhedonia & Hormone Truths

Summary

Podcast Summary: The Hunter Williams Podcast

Episode: Reader Mailbag 4 — Peptide Overdoses, GLP-1 Anhedonia & Hormone Truths
Host: Hunter Williams
Co-Host: Taylor Williams
Date: June 2, 2026

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Episode Overview

This episode dives deep into reader questions on advanced metabolic health, with a focus on the nuanced effects of GLP-1 peptides (like semaglutide, tirzepatide, and retatrutide), the challenges of hormone optimization in young women, peptide overdoses, and practical acne protocols. Hunter and Taylor blend practitioner insight with practical anecdotes and biohacker mindset. Their conversational, no-nonsense tone offers valuable context and tips for anyone navigating these frontiers of health optimization.

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Key Discussion Points & Timestamps

1. Anhedonia on GLP-1 Peptides

Timestamps: 01:53–18:12

• Definition & Reader Cases:

  • Anhedonia (inability to feel pleasure) is increasingly reported among users of GLP-1 receptor agonists—semaglutide, tirzepatide, retatrutide ([01:53]).
  • "Some people, it's like one will do it and the other one won't. Some people get anhedonia from all of them." (Hunter, [03:18])
  • Cited messages from clients reporting emotional flatness, loss of libido, anger, anxiety.

• Biochemical Mechanism:

  • GLP-1s are now known to directly lower dopamine in some users ([03:43]).
  • This side effect can be a "miracle" for those with compulsive/addictive behaviors but a "curse" for others ([03:54]).

• Susceptibility & Onset:

  • Can occur rapidly or accumulate over time ([05:18]).
  • Longer-term or higher-dose users may be more at risk, but low doses over a long period can also lead to issues ([10:13], [10:26]).

• Lifestyle & Mitigation Strategies:

  • Stress and cortisol levels can amplify anhedonia ([05:38]).
  • Emphasized importance of foundational habits: “How many hours of sunlight per day are you getting?” (Hunter, [11:06]); seasonal affective components discussed.

• Potential Interventions for Dopamine Restoration:

  • Tiered approach:
    • TeaCrine (Theacrine): 200 mg daily, non-stimulant dopamine modulator ([08:22]).
    • Tesofensine: Dopamine uptake enhancer ([08:50]).
    • 9-ME-BC or Bromantane: For more pronounced cases ([09:02]).
  • Dosing frequency and "delta" (highs and lows) in peptide levels is key—side effects often occur during rapid shifts ([15:34]).
  • Rotating or cycling peptides, reducing dose, or taking breaks can reduce effects ([10:44], [17:31]).

• Notable Quote:

  • “The bad results are in the delta, meaning that the side effects come from your body shifting, not necessarily from being in a certain range.” (Hunter, [15:34])

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2. GLP-1s and Heart Health — The “RETA" (Retatrutide) Debate

Timestamps: 19:39–31:51

• Raised Heart Rate & HRV Concerns:

  • Retatrutide raises resting heart rate and lowers HRV; question is whether this trade-off is worth it long-term ([20:31]).
  • FDA approval is reportedly delayed due to heart rate issues ([20:31]).
  • Practical advice: If resting heart rate moves from, e.g., 50→60, it’s acceptable; but from 80→95, may warrant concern and rotation to other peptides ([25:17], [27:15]).
  • Recommendations include cycling between peptides (retatrutide, tirzepatide, mazdutide) to support receptor sensitivity and lessen side effects ([20:55], [30:57]).

• Mitigation:

  • Use of beta blockers to manage high heart rate ([28:19]); short-term usage is fine if necessary ([29:05]).
  • Taurine and proper hydration can assist ([31:50]).

• Blood Pressure:

  • GLP-1s can lower blood pressure, sometimes enough to require discontinuing antihypertensive meds ([29:24]).

• Takeaway:

  • "Are we sacrificing cardiovascular health for the fat loss benefits?" Both agree—properly dosed and with exercise, it’s a favorable trade ([31:20]).

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3. Hormone Optimization in Younger Women

Timestamps: 31:55–52:20

• Core Issue:

  • A large portion of young women are hormonally depleted—mainly due to prolonged birth control and, often, SSRIs ([32:57], [33:54]).
  • “What about the girls in their 20s and 30s that just can’t seem to get things right with their hormones?” (Hunter, [32:46])

• The Problem with Birth Control & SSRIs:

  • Prolonged use can “lock” hormone receptors and halve free testosterone, leading to future fertility issues ([33:32], [34:05]).
  • “SSRIs and birth control are going to naturally shut down your natural hormone production.” (Taylor, [34:05])
  • Removal often leads to years-long post-birth control syndrome—Taylor shares personal anecdote ([36:18]–[36:35]).

• Hormone Replacement Therapy (HRT):

  • Progesterone recommended even in early 20s, possibly daily ([37:20]).
  • Testosterone microdosing (2.5–5 mg/week) can restore ovulation, enhance mood, and even support IVF success ([40:56]–[41:01]).
  • Should never combine synthetic birth control with bioidentical HRT ([46:11]).

• Fitness Culture & Peptides:

  • Growing number of young women using GLPs or anabolics; microdose testosterone/ progesterone is a safer, more effective option ([43:40]).
  • “One of the worst things you can do is use anabolics and not use testosterone along with it.” (Taylor, [43:55])

• Societal & Epigenetic Considerations:

  • Increased testosterone prescriptions for young men and women may have intergenerational benefits ([47:03], [47:42]).
  • Decline in youth hormonal health observed over decades ([48:27]–[48:59]).

• Takeaway:

  • “To me, for my partner, the health and the mental health and physical health of them is much more important than them being on birth control.” (Hunter, [39:35])
  • HRT is a vital overlooked option for young women seeking true optimization.

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4. Accidental Peptide Overdoses — What to Do

Timestamps: 52:20–57:51

• Common Scenarios:

  • Accidental injection of wrong peptide (VIP, oxytocin, etc) in excess—can cause intense but generally brief discomfort (flushing, GI upset, heart rate changes) ([52:20], [54:13]).
  • Most peptides (e.g., BPC-157) are very safe even at high doses ([53:23]), but some can cause acute symptoms.

• Remedies:

  • Hydrate, take taurine, magnesium, electrolytes; lay down and wait it out ([54:13]–[54:47]).
  • Benadryl might help in minor mast cell/allergic reactions; have an EpiPen on hand if you’re prone ([55:31]).
  • For most issues, symptoms subside in 30–60 minutes.

• Labeling & Organization:

  • Always clearly label peptide bottles and take one out of the fridge at a time to avoid mix-ups ([57:31]).

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5. Teen Acne: Optimized Protocols

Timestamps: 57:51–68:23

• Context:

  • Teen acne is both physically and emotionally scarring. Many parents try CLO peptides (BPC, TB500, GHK, KPV), but these often bring deep acne to the surface and can worsen appearance initially ([58:42]).

• Best Peptide & Topical Strategies:

  • KPV: Prefer oral or topical over injection; supports gut and skin ([59:21], [59:22]).
  • LL-37: Topical, at least 8-week course for difficult cases ([59:19]).
  • Ivermectin (Horse Paste): “Absolutely. Right away.” for breakouts ([63:02]).
    • “Put that on and it’s gone in a couple days. It’s crazy how good Ivermectin horse paste is.” (Hunter, [63:02])
  • Methylene Blue: Topical spray from Young Goose or beef tallow blends ([65:34]).
  • Image Skincare Clear Cell Line: Cleanser, toner, mattifying moisturizers ([64:01]).
  • Red light & non-ablative laser treatments: Good adjuncts ([66:58]).
  • Lifestyle: Avoid dairy, sugar, seed oils, processed foods; but acknowledge this is hard for teens ([68:09]–[68:17]).

• Gut Support:

  • Oral lorazotide can help if gut issues are underlying ([68:07]).

• Personal Reflection:

  • Hunter and Taylor both share their struggles with acne as teens, emphasizing empathy and encouragement for young people ([57:51]–[67:30]).

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Notable Quotes & Memorable Moments

• Dopamine, Lifestyle, and Anhedonia:
  • “You could go all the way upstream and say that maybe the peptide is clearing inflammation in their brain to where they're seeing reality more objectively.” (Hunter, [06:43])
• Heart Health on GLPs:
  • “Is it better to be on trap type because we’re not gonna get that? I would say for the person that experiences that super high heart rate, probably.” (Hunter, [28:19])
• Birth Control & Hormone Health:
  • “SSRIs and birth control are going to naturally shut down your natural hormone production.” (Taylor, [34:05])
• For Young Women:
  • “No, I do think that hormone replacement therapy for women in their twenties is absolutely necessary.” (Taylor, [37:25])
• Teen Acne Protocol:
  • “Ivermectin horse pace for a kid. Absolutely. Right away.” (Hunter, [63:02])

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Actionable Protocols at a Glance

For GLP-1 Anhedonia:

• Take breaks or reduce dose from GLP-1s (6–8 weeks off)
• Try TeaCrine (200 mg/day), Tesofensine, or 9-ME-BC
• Address root-cause lifestyle factors (sunlight, stress, sleep)

Heart Rate on Peptides:

• Rotate between GLP-1s (e.g., retatrutide, tirzepatide, mazdutide)
• Use beta blockers or taurine for high heart rate if needed

Young Women’s Hormone Optimization:

• Get off birth control & SSRI (taper if needed)
• Use progesterone (possibly daily)
• Consider microdose testosterone (2.5–5 mg/week)
• Do NOT combine synthetic birth control with bioidentical HRT

Acne Protocol:

• Topical/oral KPV; LL-37 topical; topical ivermectin (horse paste); methylene blue spray
• Use high-quality skincare (e.g., Image Clear Cell)
• Red light therapy, non-ablative lasers
• Address diet and gut health where possible (lorazotide)

Peptide Overdose:

• Hydrate, take taurine/magnesium/electrolytes
• Rest; use Benadryl/EpiPen for allergic reactions only
• Label all vials, don’t mix bottles during prep

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Closing Thoughts

Hunter and Taylor encourage a holistic, proactive approach: “Average health is a choice. And it's the wrong one.” Each health journey is nuanced; personalized, iterative, and grounded strategies work best. For more hands-on guidance, Hunter’s private group and direct Q&A options are available.

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Links:
To submit your questions or join the private group, Hunter provides a single link on all platforms—visit his website or bio for details.

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Episode’s Overall Tone:
Conversational, deeply practical, direct, and supportive—no fluff, no dogma, just evidence-rooted strategies. Biohacking for real lives.

Transcript

[A]

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[B]

Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you're at in the world today. We are back for another reader mailbag deep dive episode with my lovely life, lovely wife, who I have a lovely life with. Taylor, how you doing today, babe?

[C]

I'm feeling, I'm hot.

[B]

You're outside. I was outside doing some stuff in the garden.

[C]

Yeah. And it's like 95 degrees, taking care of the garden. 12 o'. Clock.

[B]

Yeah, it was funny. We had no middle ground. It was like straight from kind of cold outside, like in the 60s to straight 90s. Yeah, there's no, like 82ish days.

[C]

No.

[B]

Maybe it'll go back down. So hopefully we'll see.

[C]

We'll see.

[B]

Anyway. All right, as you guys know, these are your submitted questions. What I do with these is aggregate the ones that I seem to get a lot of and kind of put them into larger question buckets that we kind of address. And so I still do the solo Q A videos just with one off questions. But these, most of the ones we're gonna go through today are questions that we get asked all the time and a lot of times they're ones that we wanna do a deeper dive on because you know, you guys know when you watch us on the live stream, we, we're just ripping through Q and as and kind of doing quick, quick response answers. Whereas these we can take a little bit more time and break down the nuances around it. And so that's what we're gonna cover today. We've got some good ones and hopefully it's helpful to you guys. So I know this is a Big issue. The first one we're gonna talk about is anhedonia on GLP1s. And it seems to be happening now across every single one. So semaglutide, tirzeptide, and retatrutide. I've heard lots of cases of people having anhedonia on either of those peptides. And if you don't know, anhedonia basically means the inability to feel pleasure. And so we get tons of messages. And just for context, I'll read some examples of the. The messages that we received. One woman was 53, she's on T. BHRT. Thyroid is optimized. She lifts heavy, eats clean, takes mitochondrial peptides, microdoses, her GLPs. She switched from TERS to Retta and started giving anger, anxiety, and irritability and to switch back to s appetite. She loved what retta did. However, this feeling was just not doing. She was not doing very well on it. And there's a couple other ones, same thing. Tried sema, tried ters, tried retta, got anhedonia from all three. And so some people, it's like one will do it and the other one won't. Some people get anhedonia from all of them. I will say this. We do now know that the GLP is directly lowering dopamine.

[C]

Yes.

[B]

And so it's not just kind of a cascade of things that's happening. It's actually directly lowering dopamine. The I. The irony in that is sometimes that is like a miracle for people.

[C]

Yeah.

[B]

Because they have compulsive behavior patterns that that ends up.

[C]

That's why it's used in addiction.

[B]

Yeah, exactly. And so that can be a miracle for someone on the flip side and can actually be like the biggest curse to someone because they get sad, they can't feel pleasure, they have no libido. This is a big component of this. They have no libido. And so just to kind of sum this up to get us going, what is going on and who is the most susceptible to this?

[C]

So I think I. I wish I knew this part, but, like, I would love to know how long this person has been on GLPs in general. Doesn't matter which one, the time period, because I do think that it can be beneficial, like, to cycle off of them for like a good, even like six to eight weeks. Because I know now we talk about may just cycling off for four weeks, but I think really giving like a six to eight week break period and then slowly reintroducing the GLPs back in. I think you'll get less of that effect.

[B]

Yeah.

[C]

Can it still happen? Yes. Do I think you have a lower chance of it happening? Absolutely. So I think what I have seen from clients is that I noticed this kind of come on after they've been on GLPs for over a year.

[B]

So maybe it's like a cumulative effect. I think it's like overtime. You. I'd be interested to see if this. Because some people, I've heard it both ways. I've heard some people, it happens right away.

[C]

Yeah.

[B]

Like within a week or two, they're like, life just is not as fun to me anymore. And then some people, it kind of is like a gradual thing over time. I know for, like, in your case, this is not a glp, but with Krillin Tide, it was like, right away.

[C]

It was right away for me.

[B]

Yeah.

[C]

I think, though, that there's a big component here, like all those other peptides that you're using, all the. The hormones that you're using, and you're in check with everything. But what is the stress level? Like. Like, what's. Let's break down what's really causing the cortisol, because I think it's also a cortisol issue.

[B]

Yeah, definitely could be The. The problem with trying to diagnose anhedonia, which is the inability to feel pleasure, is you have no way to know. Because there's so many variables in a person's life now we can kind of say, like, okay, the. The peptide is inducing this. So it's inducing this state because they weren't like that before. With all lifestyle typically very like, set as a variable. And then you introduce the peptide and then this starts to happen. I think you could. You could go all the way upstream and say that maybe the peptide is clearing inflammation in their brain to where they're seeing objective. Seeing reality more objective. And so maybe the things that give them pleasure, like gambling or whatever, it just doesn't do it for him anymore because they're like, why I wouldn't do that. But it could also be too, that someone say they live like a perfectly happy life. They introduce gop, and now all of a sudden they're sad. I think it is directly blunting dopamine. And the issue when you get into, like, dopamine neurotransmitters, people are so vastly different. They are so different when it comes to neurochemistry. One thing can be the best thing for someone and another, it could be the worst thing for someone. And I think it probably is just a dopamine issue. To where that person, if I had to, if I had to generalize, I think that person specifically is suffering from some sort of dopamine downregulation. And the problem is like, people love the results they get. Like, I just don't want to feel like this anymore. I want to have libido. I want to be attracted to my partner. I want to enjoy when I walk my dog or go hiking or whatever it is. And if those things aren't doing it for you anymore, it can keep be kind of disheartening because you're like, oh, well, I don't get to, to use these. Or if I do use those, like I'm gonna have to be stuck with those side effects.

[C]

Yeah. So how would you suggest, like what would you do to help up regulate the dopamine?

[B]

Well, let's assume in a lot of these cases that it is dopamine. So let's say that that is like the, the factor in the equation that is causing the issue. I think you could use some sort of dopamine agonist, for lack of a better word. So something that is gonna drive that I think on the, like, on the, the easiest way to upregulate that would be a product called TIA cream. And so tea cream is very similar to caffeine, but it works a little bit more on dopamine modulation than caffeine does. Cuz caffeine is primarily adenosine.

[C]

This is not stimulating.

[B]

Non stimulating doesn't raise heart rate like caffeine does. You can take it later in the day just because it doesn't. It tends to not interfere with sleep as bad as caffeine does. Um, so I would say like on the, the lowest level I would just try some tea cream, 200 milligrams per day and see how that does. Now is that gonna fix everything for everyone? I don't think so, no. Some people it's like so pronounced that you're probably gonna have to go to a stronger chemical. But that would be kind of like the, the intro level.

[C]

Mm.

[B]

Try that. You can go one level further and you would have probably something like a tessofensine.

[C]

Mm.

[B]

So I think, and again, not, not everyone does well on tesofensing. But, but I do think that is going to help the uptake of dopamine. And so I do think tesofensine along with some of the appetite suppression benefits you'll get. I personally noticed that I have more dopamine when I have tessofensine. And so I think tessofensine Would be like, the next tier up, and then you could get into something like a 9 MEBC, which I've never personally used, but it's kind of a dopamine agonist. You do like, 10 milligrams per day of that, and that tends to help. That helps restore dopamine sensitivity. A lot of people have had addiction issues or have crashed from, like, Adderall or that are addicted to video games or things like that, and they're trying to, like, restore dopamine signaling that works well there. So that would be kind of like the strongest one. There's another one called Bromantain that's not as direct on dopamine, but it's a little bit of an adaptogen that you could get that's more of a nootropic, but that does drive dopamine. And so I think if it is dopamine driven, those would be the levers that I would pull first and see if it works. And again, may work for some people, may not, but at least you would say you give it a shot to try to keep the glpn. And I think, too, one of the questions I had written down around this is, like, is there a dose floor that someone could get to? Like, is this dose related?

[C]

Yeah.

[B]

Meaning that, like, is a person can get this on 5 milligrams per week of Reda versus 2 milligrams.

[C]

Yeah.

[B]

I think it's less likely to happen at a smaller dose amount.

[C]

But if it's a smaller dose and a cumulative amount of, like, being on the peptide version so long.

[B]

So you think even at a low dose, if they're on it long enough, this is going to happen?

[C]

Yeah, could be.

[B]

So does that mean that. I guess my question is, does the dose matter? Like, would it go away at a lower dose versus a higher dose?

[C]

I feel like. I feel like it would. I think probably titrating back down or titrating off for a short period of time and then reintroducing it gradually, I think you'll see the effects.

[B]

Yeah.

[C]

Go down.

[B]

I do wonder, too. I mean, I know people write into me and they're doing everything.

[C]

Yeah.

[B]

This sounds very.

[C]

Lifestyle has a lot to do with.

[B]

Yeah, that's what I was gonna say. It's. It's very trivial. Like, I always want to say, like, how many hours of sunlight per day are you getting? Because if you're not getting two hours of sunlight per day.

[C]

Mm.

[B]

I don't think you're gonna be as happy as you would anyway. And I do think what I'm saying is that the chemical signal of the drug becomes a lot stronger in that regard if you are not covering the baseline stuff, which would be like two hours of sunlight per day and doing it. I know people do that.

[C]

Yeah.

[B]

But it's also, I, I wonder how much of this is seasonal affective disorder, too.

[C]

Well, think about, like, think about how, like I would say, let's use me as an example. Think about how. How some of the things that I was feeling in, like, March and April and how I kept telling you, like, I was feeling, like, emotionally flat. Like, we were talking about how, like, obviously, like, fertility and just, like, emotions were high. Feeling emotionally flat. That's when I was on a glp. It was also like, February. March is not a fun time of year in North Carolina. Like, it's. Yes, it could be worse. It could be like, you know, the Midwest. It could be North Dakota. But, you know, then we're also, you know, we sat down and we really talked about everything and really broke down on things that were stressing me out and things that I wasn't feeling in line with doing. And now removing some of those stressors out of the lifestyle, I'm in a much better place. So was it really the retitrutide or was it really the stress levels plus the glp? You know, that's. I think, I don't think in your

[B]

case it was retitrutide at all.

[C]

No, like I said, I think, I think a lot of times, like, I do think a lot of it is lifestyle stress base and sometimes not saying all the time, but I think that's a big portion of it. And when you're not feeling in line to, like, what you want to, like, truly like what your heart is telling you to truly be doing, and then you add in these wonderful molecules that we have, like GLPs, you know, I. That can.

[B]

Well, I guess that's the. I guess that's a broader question, right? Is it the. Are these the real red pill? I've always kind of joked testosterone's the red pill because it'll wake you up to what's your life? And then you kind of wake up one day be like, what am I doing with my life? Because your hormones get normalized and that's like the peptides doing the same thing. Are they, for lack of, lack of a better analogy, a red pill to show someone in their life.

[A]

Yeah.

[B]

What's there?

[C]

I don't think these are used for addiction.

[B]

Yeah. What's weird, because, like, I've heard Is. Is equally as. I hear this, I hear that GLPs make someone's life infinitely better.

[C]

Yeah.

[B]

From a mood standpoint. And so it's weird because, like I said, like, in one way, you have this contingent of people that is having the worst mood experience ever. And the other people, it's like, I can't tell you how many messages I get every day, especially when I. The content I talk about is related to GLPs, and they're like, you have no idea how much these changed my life. And so I do think there's. There's that side of it too. I think to drive to the heart of this issue, it really is probably a dopamine thing in a lot of cases. And each person is gonna have to figure out, like, what drives their dopamine. Dopamine.

[C]

Yeah.

[B]

Differently. It's tough for me. So I'll say that. Just like, personally, personal experience. I don't know that I've ever had anhedonia, but I've had pretty bad depression and anxiety, especially before I got, like, my hormones optimized and everything. I would say I had, like, at some points in my life, I had, like, pretty bad depression. And I won't go into that, but I will say so. I've felt that, but I don't know that I've ever felt, like, an inability to have pleasure. Because even being depressed, there were still things to me. Like, going to the gym was like. I mean, still a lot of times it's a highlight of my day. It was like the highlight of my day. I was like, okay, like, I still. As bad as life felt at that time, it was like, I still had that, and that kind of like, got me through that. But it's got to be weird to feel where it's like your life could be going perfectly and then you don't feel pleasure from that. And again, I wonder how much of that is driven by the short circuiting of rewards in our brain via, like, phones and notifications and things like that and then how much the GLP plays into it. So I'm not saying that, like, GLP doesn't have an effect, but I wonder, like, how much is layered on top, like, how much of that.

[C]

I think it's a layered layer problem.

[B]

Yeah. And so I think also, too, I wonder how much of this. This person said, one lady said she was microdosing. How much of this is driven by, like, big peaks and big troughs. What I've noticed is that a lot of times when we talk about peptides, we talk about hormones. The bad results are in the delta, meaning that the side effects come from your body shifting, not necessarily from being in a certain range. And so when you have a big peak and a big trough, you have bad side effects because you're going from a high to a low.

[C]

Yeah.

[B]

And if you can manage that with more often or frequent dosing, you can control yourself in a more defined range to which at least then you have a better response. If you're trying things with dopamine. But like imagine if you did one week, one shot of 8 milligrams of reta and then you're feeling this way and then you're trying to fix dopamine and like maybe on Tuesday it feels good and Thursday it doesn't.

[C]

Yeah.

[B]

You know, and so I, I wonder how much of that plays a part. Maybe it doesn't at all, but I

[C]

think that plays a part. I noticed that like when while we've been experimenting with like Mass youtide. Like because I started off just doing it just once a week and getting that like that drop effect by the end of the week.

[B]

Yeah. Like I would tell you this for the first two weeks that I did that with Mass Do Tech. Cause I wanted to see how it responded over 7 day period on a low dose. I will not be doing that again because I don't like how that feels.

[C]

No. I don't like that.

[B]

I'm like man. Cause you get so accustomed to doing it one way.

[C]

Yeah.

[B]

Of like splitting up the dosing and it's kind of just like I don't like how that feels when I am just doing it once per week, even a low dose. Because you see more of the side effect profile even at a 1mg dose versus if you took 2mg and you split it up twice per week. I think it feels better than just taking 1 milligram one time per week. So. But yeah, I guess to sum some of that question up, does this mean that GLPs are completely off the table for these people?

[C]

I think there's a lot of other things that need to be done first before just writing off the glp. I would say if you really go through and dissect everything that we talked about.

[B]

Yeah.

[C]

Then maybe the GLP is just not for you. Maybe trying an oral glp it would be better.

[B]

That would be interesting to see how. Or fork leapron.

[C]

Yeah.

[B]

Do in that regard. I just haven't heard from enough people have used it yet because it's less common to see out There. Okay, so long story short, tldr, if you can do anything to fix dopamine, I think that's gonna be the best thing that you can do in the case of GLP driven anhedonia.

[C]

Yeah.

[B]

Because we do know now there has been studies to show that it is these, these were mice, but they do know that it was down regulating dopamine, which again could be a good thing, could be a bad thing. But moving on, this is still gonna be another Reddit true type question. Honestly, like, so funny with like GLPs, like how big they are in the, the hive mind, mass consciousness right now could literally just do like hours and hours and hours and hours of the successes and the problems of glp.

[C]

Can we go back to the GLP really quick to that last question, the anonia?

[B]

Sure.

[C]

Do you think that, did they say that they had it with TAT or.

[B]

Some people do. Some people say it's one, not the other. So some people say it's all of them. Now they, we do know they all have a GLP1 component, which we know the GLP component is what is down regulating the dopamine specifically in a lot of cases, I think semaglutide, it seems to be more just because that's all GLP. And so like a 2 milligram dose of semaglutide is like probably equivalent to like a 6 milligram dose of retta with the GLP component. Like you're getting as much GLP out of that. Okay, higher dose.

[C]

So never mind my thought. Okay. I changed my thought process.

[B]

Yeah. Who knows? And I think the cool thing is now is like GLPs are great, but I was off for like six or seven weeks and it's like we have so many things out there that it is not. I think the GLPs are the best, obviously, but there are other options if you just for whatever reason said you can't use them.

[C]

Yeah.

[B]

To maintain fat loss. Anyway, next one on Reddit is basically about heart health. And so there's a big thing now. I got sent a bunch of questions. I guess there have been social media types of that are talking about basically on long term Retta. We know that Retta raises heart rate. Long term, we know that Retta probably is going to decrease HRV because it's raising heart rate. The question is, is this sustainable? Meaning that like we're kind of in this experiment right now. Is it sustainable to have a higher heart rate and you have a lower HRV on Reddit? Is the benefit worth the cost of that. Because if you look at your aura ring, that aura ring is not going to be as good on retta as it is. But you might heck of a lot like what you see in the mirror.

[C]

Yeah.

[B]

And so the question is like, where are we at this trade off? Because I've, from what I've heard, this is actually what's delaying the RETA from being FDA approved is they have had some heart rate issues in the trials. And so I think the question, the general question that we got was like, can we use this forever or do we use RETA to get where we want to go and then go back to Tide? Because we know we're not going to have as much of that.

[C]

I think that you can. Okay, let's break this down a little bit too because I know we've talked about this a little bit on our. One of our coffee talks is that it's not, it's the RETA is great, but it's great because you have the glucagon receptor in there. And I think it's because you're combining glucagon, glp, gip. Like a lot of people think it's the glucagon that's causing the increase in heart rate. And I think it's more so combining all three of those receptors into one. So I, I personally think that it's good to kind of do like a rotation of all the GLPs just to help with receptor sensitivity and they all can kind of pair a little bit differently. Now would I really use semi glutide by itself? No, but I mean that's just me personally. I think that you can get really great results. So let's say if you are somebody who's having the issues with the heart rate, I would say use RETA for, you know, anywhere for like 8 to 16 weeks, get the results that you want and then cycle off of it and then switch over to another none other glp, whether it's tirzepatide or mazutide. At least with the mazutide you are still getting the glucagon in there. You just don't get the gip. And then with trazeptide you're getting the gip. So I think it might be beneficial to rotate. Might be more beneficial if you have the increase in heart rate to rotate between mastutide and tirzepatide. That way you're working with, with the glp that's only triggering three recept or two. I'm sorry, they're only working on two receptors rather than all three. Yeah, like retta. So I think that, I think it's just good to do a, to do a rotation. It's kind of like when I used to do hair, I used to tell my clients to like change up your shampoo. Don't keep using the same like moisturizing shampoo, Change it up. And also use a volumizing one, use a smoothing one, Use like change up even like your products. So that's why I say like it's good to change up and use a different receptors. And I. Because I do think there's a lot of really great benefits you have with using glucagon. And I think that people are missing out on that if they just completely write off like glucagon altogether.

[B]

Well, I'll say this. It's my third week of trying mazutide. It is definitely different than retatrupcide. Yes, I think definitely what I'm saying is that like you would think like, oh, it's gonna be that much different. I don't know, it's. Something is different about it for sure. And I can't quite put my finger on it yet.

[C]

But I think using mastutide more so for fat loss and more so like for the liver I think is going to be more beneficial. And I think maybe using like tirzepatide more for longevity and anti inflammatory is better.

[B]

I would say if you, if you gave me one. This is a really tough question. Like if you had to do one, if you got to do one shot a week or. Excuse me, one shot a month of a GLP is like kind of just like a maintenance microdose background. Would it be red atrutide or would it be terzepatide?

[C]

I think it's. I mean for me it's hard for me to answer because I don't get the heart rate issues with reta.

[B]

Yeah, you really don't.

[C]

I don't. So I would still pick the retta, but if I was somebody who had the heart rate issues and anxiety and that I would pick the terz appetite.

[B]

I also think it's relative to like, where is the heart rate itself? And I, I'm like in my head, I'm telling myself, like, don't go there because then what I'm gonna get is a bunch of people asking me like, well, my heart rate's this. Can I do this? I will say, generally speaking, and this is not gospel, because nothing I say is gospel by any means. We're literally just talking about this, like, this is just entertainment and educational purposes. This is not for like what you should do. So here's an example. Someone's resting heart rate is 50, they take Reddit, it goes to 60.

[A]

Okay.

[B]

I mean, really, is it that bad? I think for what you get? No. Like you're gonna be perfectly fine in a lot of cases. In some cases maybe even a little healthier because I think you're actually getting. Sometimes I think your heart rate can be too low. I'm not saying 50 is too low. Yeah, but sometimes, like, I don't think that's necessarily a bad thing. I wouldn't even consider that a trade off. Just like, hey, your, your resting heart rate went up, now your HRV going down. I think there's things that you can do to mitigate that. But understand you're probably not going to run the same HRV if you're on retta. Like that just comes with the territory.

[C]

Yeah.

[B]

Although I will say I haven't been wearing my aura ring lately because it broke. I don't want to buy a new one because they're, I think they're overpriced for what you're getting. Sorry to like, I'm not trying to disrespect aura or anything, but like I like it, but it's like $400 for.

[C]

I see that.

[B]

Cuz I could pretty much tell you what my score is going to be once you get to the point. You can pretty much tell what the score is going to be in the morning. I'd say I could. With 90% accuracy. I could tell you like a range of 5 to 10 points of like my HRV heart rate, sleep score of what it would be.

[C]

And it never, it never really tracked my temperature properly, which was just like the whole point of me getting that was.

[B]

Are you sure that wasn't user error? I don't know. I don't know the temperature feature. I'm just kidding.

[C]

I feel like my water ring never really worked properly. I think it worked good for like three months and that was it.

[B]

But yours did seem to die very. Like mine took a while before it started dying, like every 12 hours. But yours started to die like months before mine did. Early.

[C]

Yeah, I also put in the wash a couple times.

[B]

Oh, interesting. Anyway, so to go back to it. Pattern interrupt yet your heart rate goes from 50, 60. Is that that bad? I don't know. However, I do know people. Maybe the resting heart rate was like a 75 or an 80. And Reddit true tie takes is like a 95. That. That's in a short window. I don't think it's bad. But if you're taking that longer than like 812 weeks and it's not coming back down, I personally wouldn't want mine sitting that high.

[A]

No.

[B]

And so I probably, if that was the case, I would say use retta to get to your goal weight and then go to perzepatide to not have that happen.

[C]

Yeah.

[B]

And so 50 to 60. I don't think it's me an issue like you like me.

[C]

Yeah.

[B]

I would say, like, retta for me usually, like, would push mine into the high 60s. So I would sit like mid-50s to high 50s. Heart rate, it would push it to like the mid to high 60s. And my heart rate, I know, would be lower if I didn't take desiccated thyroid. That obviously like bumps your heart rate a little bit. But I'll say that for me, I was always fine right there. And even after sustained use, it kind of would normalize around like 65. And so I felt fine even at 4 or 5 milligrams of retta. I'm sitting at 65. Like, I'm not worried about that. So I would feel comfortable myself doing that long term. However, I know if I went to Zaptide, it would probably go down and then my HRV would probably go up a little bit. I think the question, do we. Do we know conclusively if that's going to be bad for our heart long term? I don't know. And I think if you look at every objective market that we have, other than those two.

[C]

Mm.

[B]

We know that it's doing good things right at true tattoos. But I think the question is, is it better to be on trap type? Because we're not gonna get that. I would say for the person that experiences that super high heart rate, probably. Now one of the questions we got was about a beta blocker. So it's like, obviously your heart rate goes up, take a beta blocker, goes down. I don't have a problem with that. If it makes someone tolerate it better. I don't inherently see anything wrong that I could see in the data from long term beta blocker, you know, use. And so like, you could combine it with that. I wouldn't have an issue with that. I wouldn't need to do that myself. But if, if I was that person that went up to 95, you take a B blocker goes down, I think that could help. Especially if you need to get to a certain point that's going to Be obviously like healthier to get the fat off to get where you need to be.

[C]

I agree with that. Think it's short term usage.

[B]

Yeah. For someone. This was part of this too. For someone with existing high blood pressure meds is read off the table. No, I don't think so. I do think, and you see this in the clinical literature too, and I've seen this practically, Retitrutide will end up causing a lot of people to have to get off their blood pressure medication because it might drop their blood pressure too low.

[C]

Yeah, it does.

[B]

And especially if you're doing Red up plus Jardians.

[C]

Yeah.

[B]

That can drop your blood pressure really low.

[C]

Yes.

[B]

And then you have that. You've seen that firsthand and so that firsthand. Yeah. I think a lot of cases. I know for me, like a GOP and Jardiance, I don't really have to take Telma Sartin at all.

[C]

Yeah.

[B]

I think there's benefits to taking Telma Sartin. If I didn't take both of those together. I may add it in, but I think so. We talked about Mazdu tied for maintenance. Like, I think Mazdu tied could be something that you rotate between. I will say this. I was on Retta for like six to seven months consecutively. I took like a month or month and a half off and I went to Mazdu tide. I can't say whether I would have responded to Retta like it was the first time if I had just like picked it back up.

[C]

Yeah.

[B]

But mazdutide felt like the first. Like it. It basically was like I had never taken a GLP before.

[C]

And the question is exactly how it felt.

[B]

Was that. Was that because I was offered six or seven weeks?

[C]

No, because I was it.

[B]

Because it's a different. Yeah, because it's a different drug.

[C]

I think it's because it's a different drug. Because I was only off of Vertatrutide for like three or four weeks and I started taking it. I started taking it before you did.

[B]

And it hit hard.

[C]

And it hit hard. Yeah, like it hit hard. It's still hitting hard.

[B]

Yeah. And so that's the question. It's like, what if you just bop back and forth ters Mass Reddit turds.

[C]

Yeah, well, that's what I said.

[B]

And you don't realize earlier, obviously you're stimulation. Yeah. You're stimulating the receptors. But I think the key is a little bit different on that lock and it's going to work a little bit differently.

[C]

Yeah, I think it's Good to rotate. Because I think think of it too as like. Okay. Like you get comfortable.

[B]

Yeah.

[C]

With something.

[B]

Yeah.

[C]

Gotta rotate.

[B]

Final question on this. Are we, in closing, are we sacrificing cardiovascular health for the fat loss benefits with red? I would say no.

[C]

No. If you're properly exercising.

[B]

Yeah. Well, that's the thing too. Is like the thing.

[C]

A lot of people don't.

[B]

How the. Yeah.

[C]

Don't.

[B]

Their heart rate would be improved if they were doing. Doing some three or four hours of cardio per week. Yeah, yeah, yeah. There's so many variables, it's hard to say. But I do think it's an interesting topic of conversation. It is definitely one of the ones that you see a lot. Obviously we didn't even mention taurine. Taurine is huge. So like taurine could be very beneficial to the heart rate equation side of that. And so keep that in mind.

[C]

Yeah.

[B]

Okay. This is right up your alley. Throwing you a softball.

[C]

Okay. I think, I think I did really good with the hard ones.

[B]

Okay, well, I think this will be a good topic of conversation. So it's about hormone optimization for younger women. Younger women. Okay, so I got two questions. One was actually from a guy. He was reading my book and he's like, this is great. Guys can use testosterone, but what about women? He was in his mid-20s and he's like, all the women that I talk to, they just are destitute hormonally. Like, what am I supposed to do? Like, all of them are crazy because he said it, but all of them are crazy because, you know, similar conversations, their hormones aren't optimized. And so when we look at this, especially considering that a woman in her 20s or 30s probably is going to want to have kids at some point. How do you address hormone optimization? We talk so much about Perry and postmenopausal.

[C]

Yeah.

[B]

Women with hormones, which obviously is a very needed thing because that's a very underserved market.

[A]

Yeah.

[B]

But what about the girls in their 20s and 30s that they just can't seem to get things right with their hormones? What are the options?

[C]

So hormone optimization, like, is not bad for women in their 20s and 30s. I think the first step is throwing away the birth control.

[B]

Well, that was my next question, actually. I probably should have said that first when I was writing these out, because you have a lot of these women. They're even a 25 year old woman can be coming off of a decade of birth control.

[C]

Yeah.

[B]

From the age of 15 to 25, she's on birth control and now she's

[C]

I mean, there are people. I mean, there's. There's girls that go on birth control the age of, like, 13 now.

[B]

Yeah. And then they get to 29, 17 years later, and they've been on birth control.

[C]

Yeah.

[B]

We know. On average, that will cut their free testosterone in half.

[C]

Yeah.

[B]

Which they don't a lot of times have that many. That much to begin with.

[C]

Yeah.

[B]

Because of the. The environment.

[C]

Yeah.

[B]

Yeah. It is a. It's a very tough question. You have millions of women in their 20s and 30s walking around teens, for that matter, on birth control and a psych. Psychotic medication, like an SSRI.

[C]

Yeah. So both of those things are going to SSRIs and birth control are going to naturally shut down your natural hormone production.

[B]

Mm.

[C]

And this is coming from somebody who was 15 years on synthetic birth control and getting off of it.

[B]

And didn't you take an SSRI in combo with that?

[C]

In combo with that, I did get prescribed an ssri.

[B]

What did that feel like in combination with birth control?

[C]

I took it for a week and I. Yeah. And I was not, like, it was not something that I wanted to do. And I remember. I remember going and meeting and talking to a counselor about everything. And she was just a therapist, and she looked at me. She's like, there's nothing psychologically wrong with you. This is a hormonal deficiency. Like, you need to go get this IUD taken out immediately. And I did. And I was very. It was a very much. I was flat and had, like. It was like anadolia. Like, just. How about Anadola? I was just, like, numb. Like, I just, like, did not care about anything. I had no empathy, had no appetite. Like dopamine. I had no dopamine. So that was. Tried that for, like, a week. And I was 22 at the time. Yeah. So I think that what a lot of people don't realize is that those also cause. The SSRIs will actually also cause your natural hormone production to go down. Then you have birth control on top of that. The birth control, synthetic birth controls are going to block your natural testosterone production, your natural progesterone production, and your estrogen production. It locks onto those cells and it prevents that from being able to basically grow or develop or anything. It blocks it. So, you know that's going to cause your hormone levels to go down, and that's actually going to cause you to have more fertility issues in the future.

[B]

Yeah.

[C]

So. And that's, like, where a lot of people don't think. Now, do some. Do some people have issues Once they get off birth control.

[A]

No.

[C]

Know, some people get off birth control and they get pregnant right away. I know for my case, like, it took like several years for me to ovulate after being on synthetic birth controls. I didn't ovulate for three. Three years is what we tracked.

[B]

Yeah.

[C]

And I didn't ovulate until I started injecting testosterone. So who knows? It might have been longer if I had stayed on cream, maybe not. But I mean, I had been on testosterone cream for a year prior, still never ovulated, started injecting, and then several months later started ovulating again. So I don't think that hormone replacement therapy is out for younger women. I think starting off with progesterone days 14 through 28 in the menstrual cycle for women in their young 20s can be very beneficial. Honestly, I don't see an issue with using progesterone year round. Some people are going to argue that. With me personally, I feel better doing that. And it doesn't mess with my menstrual cycles.

[B]

You mean the entire cycle?

[C]

The entire cycle, yeah. Taking it every day.

[B]

Yeah.

[C]

So, no, I do think that hormone replacement therapy for women in their twenties is absolutely necessary. I think that so many more women now have issues with pcos, which they did change the name of pcos,

[B]

and

[C]

that's more so from being insulin resistant, not from high levels of testosterone. That's. I'm very glad that's now been, like, explained better. But that's where testosterone and progesterone can help women in their 20s and early 30s. I think for men, that if men are wanting to start testosterone therapy in, you know, in. In their late 20s, early 30s, and they want to have kids and they don't have children yet, I think that, you know, options like look at getting your sperm frozen, it's a lot easier for a man than it is for a woman to get man. For them to get their sperm frozen versus a woman to get their eggs frozen. I would look into that. And then I would also look into using HCG to keep the natural production of the testosterone growing as well.

[B]

Yeah, I think to the, to the women's point here is what I would say is like a gross generalization that I think you could approach it. Most women 20s and 30s or on birth control, plus or minus an SRI SSR, I think the best thing you do is throw the birth control in the trash. Now people gonna do that? No, they. They would rather be on birth control and not risk having an unplanned pregnancy. Than to do it. In my opinion though, as a man, it's an interesting conversation because like, as a man, I would take more responsibility over the pregnant, like getting my girlfriend or wife pregnant. Then I would rather have to see her on birth control. But that's an easy thing for me to say.

[C]

Yeah, but like what if like you're like two months into dating somebody?

[B]

Well, there's no easy answer. What I'm saying is as a man,

[C]

I mean, it wasn't you when we met. Like, I wasn't on birth control. Like, Correct.

[B]

And I wasn't like, you need to get on birth control.

[C]

No, like you met.

[B]

You're like, okay, yeah, I would even responsible. So again, not everyone's going to do that. But no, to me, what I'm saying is that for my partner, the health and the mental health and physical health of them is much more important than them being on birth control. But a lot of guys, they might not see themselves long term with that partner. So hey, maybe, you know, it's like, well, there's. Yeah, get what they can and then run away.

[C]

But then there's other ways you can prevent pregnancy.

[B]

Yeah, exact. That's just birth control.

[C]

There's other practices.

[B]

That's what I'm saying.

[C]

Just birth control.

[B]

It's so bad for a woman. There are so many other stops along the way before I would get them on birth control. But hey, you have parents putting their 13 year old daughters on it for acne, you know, or whatever, or hormone issues. But.

[C]

And all that's going to do is make the hormone issues worse because it keeps you.

[B]

My order of operations would be throw the birth control and the SSRIs away. You can stop the birth control. You would need to taper down off the SSRIs. Get those out of your life as fast as possible. That's like tens or hundreds of millions of women are on that right now. So get those out of your life as fast as possible. From there. Step one, get some progesterone. I think that's like the bare minimum.

[C]

Yes.

[B]

Like you said, maybe it's 14 through days, 14 through 28. Maybe it's every day. Figure out what works for you. Yep, get some progesterone and then from there. Ironically, there are studies to show that testosterone replacement in women enhances fertility outcomes, particularly in ivf.

[C]

Yes.

[B]

A lot of times they give women on IVF testosterone. In the, in the studies, they give them gel.

[C]

Yeah.

[B]

And it enhances their fertility outcomes and it also enhances their ability to carry the pregnancy to term, yes. So they actually like have a higher chance of bringing the child into the world without a miscarriage. With testosterone. Preconception.

[C]

Preconception, yes. Not during the pregnancy.

[B]

Correct. But leading up to the conception. Okay, so we know that. And so progesterone first. I think it would be perfectly reasonable for a woman that's in her 20s to start a microdose of testosterone, even maybe more so than a man, because they don't have typically at the right dose the side effects on fertility.

[C]

Yes.

[B]

And so I think if you took a 25 year old woman, she's distressed,

[C]

they don't have the negative side effects.

[B]

Correct. She's distressed, she's distraught. Men can obviously, like we talked about, mitigate that with hcg. If you do that, a lot of guys won't even run into issues because they're using HCG from the start. But anyway, you see that and it's like, okay, even those two things. So progesterone and testosterone will fix so much and all of a sudden their life is better. I think in that case, a lot of issues if they're not married yet or not in a long term relationship, they're on testosterone. It's gonna be the red pill for them to go back to that. It's gonna be really hard for a woman in her twenties that's like hormonally optimized now to go out into the male dating pool and find a male that is also hormonally optimized. But again, hey, that's like just part of life, right? You gotta find your person if that's what you want to do. But yeah, I would say that would be how I approach that. And I think you do that. It's just like your daily lifestyle and then once you get pregnant, you stop it, the testosterone and then you have your kids and then you go back on it. But you know what's interesting is we have this huge like part of fitness culture now. I haven't realized until people have told me like how crazy it is with like sorority girls using peptides and all this stuff.

[C]

Yeah, I didn't realize that.

[B]

I think if you look at peptides, like the growth market of whatever it ends up being, whether it's telehealth, research, whatever is so big because these kids in their 20s now are like on peptides and it's going to be like the biggest thing ever, I think in 10 years.

[C]

Is it more so like, is it like the sorority girls are all on GLPs?

[B]

Mostly, of course.

[C]

Mostly, yeah. And Then are like the guys, like, trying to do growth hormone releasing peptides.

[B]

Well, I think a lot of guys are on GLPs too. Yeah, that's what, that would be the, the thing. But what I'm saying is, like, you have this fitness culture and now peptides are becoming much more accepted. I think it would be a lot better for a woman in her 20s to start with a microdose of testosterone than to get on Anavar or something. Because, you know those chicks are doing that. Like, they're getting on Anavar, they're taking anabolics that they shouldn't. They're using a lot of peptides and stuff.

[C]

Yeah.

[B]

I would feel much safer if you just got up on testosterone and progesterone.

[C]

Yeah.

[B]

And then throw in a GLP if you need it on top of that. Like, there's, I think for a woman, there's like, this is what no one talks about is like, there's essentially like, very little downside to do that.

[C]

I think one of the worst things that you can do is use anabolics and not use testosterone along with it.

[B]

Yeah. I mean, how many naturally.

[C]

Yeah, you're gonna feel good, like using, I mean, time for a time, like, because you do feel good when you, when you use those. But it's gonna shut your natural production.

[B]

Yeah. Like eight weeks of Anavar, 12 weeks of Anavar. That's going to shut down your natural production. You're gonna feel good, you're gonna look

[C]

good, you're gonna look great.

[B]

And then all of a sudden, and then you're gonna crash, crash. And then you're gonna feel terrible. And then you're gonna have to worry then. Then your testosterone is gonna be shut down. If there was any to begin with.

[C]

And the lower.

[B]

And your estradiol is gonna be lower because you're using a DHT compound which is gonna.

[C]

And you're at a higher risk of losing your menstrual cycle. Like, I know fitness competitors that have used anabolics in the past without testosterone completely lose their menstrual cycle. Thyroid goes. They should basically shut that down. And. And then they run cycles with the same amount of anabolics they did in the past, but then they add in desiccated thyroid and then they add in therapeutic amount of testosterone, and they don't lose their cycle during their cut season.

[B]

Yeah.

[C]

Because they still have the production going on with supplementing with testosterone.

[B]

You know, one of the most dangerous things I think people do is compete in natural bodybuilding competitions because they're actually at A way worse health disadvantage. Like if you look at the blood, blood work of some men and women, natural bodybuilders, it is awful, awful like what they do to their bodies because you're basically putting yourself through that. Their liver usually is just like liver's trash.

[C]

Trashed. And a lot of people would think like their liver would be. No. Do I think some people, their livers are trash that you overuse anabolics. Yes. But like the people that are natural versus using like small amounts of anabolics, like it's just like the blood work comes back better.

[B]

Yeah, yeah. But anyway, I think that in terms of like the whole fitness culture, there are a lot of women that would probably be better off with a microdose, even if it's just like two and a half to five milligrams a week of testosterone than what they're doing, which is like training really hard. Putting themselves through this. Being on birth control. Yes, Doing that. Like having to maintain an image of fitness and whatever.

[C]

Also too, you do not want to be on birth control and take testosterone and progesterone. You do not want to do that. Cuz I. That has. People have, has come up. If you are on synthetic birth controls, you do not need to be using bioidentical hormone replacement therapy. Yeah, pick one or the other. I'd pick the hormone replacement therapy, but do not combine them.

[B]

Yeah, yeah, it's. It's a tough thing out there. You know, I think of the, the younger generation, it's so. I mean we're in our 30s, but like they just don't really know where to turn. I will say this. Statistically speaking, from 2019 to 2025, the amount of prescribed testosterone by doctors to men in the 18 to 25 age group was up like 140%.

[C]

That's awesome.

[B]

And then 25 to 34, I think was up like almost 100%.

[C]

That's awesome.

[B]

Now what that tells me is like over the next 20 years, all of those guys like that has become much more common than the guys that are in their 50s and 60s now. Like you're going to see way more people, I think in actually for women, Testosterone prescriptions, like 2000 for women, there's like 1 million women and most recently there was like 12 million women. So like in 25 years we've seen like a 12 fold increase in the women using testosterone. But we do see in young men, that younger age group there is a much more clinically prescribed like increase of testosterone in those age groups.

[C]

I wonder. I think that this could be something that maybe we'll see a shift in the next generation. Like the generation that come from those people that are being prescribed testosterone. Three children. If we'll see a change in the development of those children. Because I definitely think. And in a positive way, I don't think it's going to be a negative impact at all whatsoever. I think it's going to be a positive impact and probably save humanity.

[B]

Well, maybe that's. It's interesting if you look at the, the genetic modification or epigenetic modification of the human race. We were talking about this the other day when I was in high school. I had a full beard when I was 14 years old. And that was not rare. Like, that was. Most guys in my football team.

[C]

Yeah.

[B]

Had a full beard when we were in high school.

[C]

Yeah.

[B]

Early high school and then to late high school. I was like, my football team, like. And we were pretty good. But like, it was like grown men. And now you go to a high school and there's like good athletes, obviously.

[C]

Obviously. But there's not.

[B]

The look of the guys is not the same. My mom would always talk about that because she was a football mom in 2007, from 2007 to 2023. And she would talk about, like, the transition of like, from those 16 years of being a football mom for me and my brothers, of how different the males looked.

[C]

Yeah.

[B]

In that window. And so to your point is like being on hormone therapy because of the. The instate, the health instate of the parents confer better genetics in utero to the kids to like, where they don't have as much of the epigenetic modification from the plastics and the EDCs and everything. I would hope, I think when we look at glp is improving fertility, obviously, like hormones improving fertility. Done in the right way with the right things. Like, Dr. Shana Schwann has this. Brook has this book, it's over on my bookshelf called Countdown. It's basically about, like, how plastics and chemicals are killing the human race.

[C]

Yeah.

[B]

And if you extrapolate it, it's going to be like done in like 20 or 30 years. Now do we get there? I don't know. I mean, I don't think that'll be case. But like you said, are GLPs and hormones like mankind's last hope of existing? I think if you look at it from like, from a standpoint of like, existing in a healthy manner.

[C]

Healthy manner, yes.

[B]

Because like the normal personnel, if you don't do these things, like, you're just Gonna be, like, unhealthy by default.

[C]

Yeah.

[B]

In a lot of cases. And then if you even do the right things, I think you're still not gonna be as healthy as possible. Like, there's some people that, like, do everything right and they're perfectly healthy, but, like, it's hard to have hormones that are optimized. It's hard to do the. Even if you're doing everything right from a lifestyle standpoint.

[C]

Yeah.

[B]

And so to that point, it will be interesting to see, like, if these, like, is. The human race is, like, always developing in a way that's like, we have things that come against us, and then we, like, come up with these interventions. You know, like penicillin. Like, penicillin saved so many lives. Like, think how many people used to die in battle or from getting a cut. They got infected. Like, used to, like, if you got a flesh wound in the Civil War, like, it was like, you could. That could be a death sentence, just a flesh wound, because you can get infected and get gangrene and then you're done.

[A]

Yeah.

[B]

And like, are we in this inflection point now with some of these medications that they're like, for the modern lifestyle, which is basically, like, being a blob person is like, what your greatest risk for a lot of people is, becoming a blob.

[C]

Yeah.

[B]

Do these, like, help. Help with that? I think so. I mean, we're probably in that point now. Like, we'll look back at GLPs and be like, that was a penicillin moment. And then there'll be better. There'll be better ones and be better things and whatever. So anyway, to sum up, I have no problems with women. Yeah. I think it's good because this is where this leads, because I think it gives people context for, like, understanding what we're dealing with here.

[C]

Yeah.

[B]

We are dealing with millions of women between the age of 18 and 35 that are destitute. And in a lot of cases, they're trying to do everything right, and they don't know where to turn. And they don't even know that testosterone is an option for them. Progesterone is an option for them. No, I mean, just think of, like, the massive amount of anxiety in that age group of women.

[C]

Also, I want to go back and say too, when you also block your natural hormone, hormone production, when you block your estrogen, your testosterone, and your progesterone cells, that's actually going to give you a higher risk of diseases to happen that are going to be more life threatening.

[B]

Yeah. I Mean, a lot more chronic disease

[C]

is going to happen.

[B]

More chronic disease occurs when hormones are low.

[C]

Yeah. You know that for when you block them.

[B]

Yeah. And especially when you're blocking them. Yeah, yeah. So, yeah, it's bio hormone replacement therapy

[C]

is not going to trigger those chronic diseases to happen.

[B]

Yeah. If anything, it's going to be better for that. And unfortunately there, I think in the older generation, 50, 60, 70 age group, they have been brainwashed to think that hormones are bad and cause cancer. So anyway, this will be an interesting question. We can talk about, we can share some of our personal experience. So let's talk about accidental overdoses of peptides. So someone. I've done this before. I will, I will not claim that I haven't done this before. Meant to inject their BPC and they accidentally took Vip because I guess they didn't have them labeled. And she did way more basically like three times the amount of vip. If you've never used VIP injectable, the experience is very similar to oxytocin. Flushing, heart rate, increase for VAs dilation, probably get like a headache. Some people feel like they're dying if they don't know what's going on. And so I've heard this a bunch and I thought it'd be a good question to ask. If we accidentally over inject peptides, is there anything that you can do or should you be worried?

[C]

No, I mean, I mean, I guess it all just depends on the peptide. But I mean, I mean, I could inject an entire bottle of BPC and I would not be worried.

[B]

Yeah, it definitely depends on the peptide.

[C]

Depends on the peptide.

[B]

You can inject five bottles of BPC in a row and it's not going to do.

[C]

Not gonna do anything. Entire bottle of vip.

[B]

Oh, yeah.

[C]

Not gonna feel good. Inject a bottle of oxytocin. That's not gonna feel good either.

[B]

Yeah, Like I've done this with oxytocin, which has a very similar experience to this.

[C]

Yes.

[B]

And I did 300 micrograms instead of 30 micrograms just because I wasn't paying attention when I mixed it and measured it and everything. And fortunately, like, there wasn't anything bad, but you do have to deal with probably about 30 minutes to an hour of some very bad discomfort. And for me, that was sitting on the toilet. Yeah. With oxytocin, VIP can kind of do the same thing.

[C]

I think one of the best is to hydrate and take some extra taurine. Take some extra magnesium.

[B]

Yeah.

[C]

And take some extra electrolytes.

[B]

Well, think about this, like, if you. If you do accidentally overdose, I think the worst ones would be vip, Oxytocin, melanitan. Yeah, you take too much melanin, you're gonna get really, really nauseous. Those are the worst ones. I think if you overdose on a glp, it's not gonna be right away. It's gonna be like three and four is gonna be really, really bad, and you just kind of have to, like, bite the bullet. There's no that's gonna be there, and it sucks. But, like, I've done that with, like, set. Melanotide is like, the worst GLP feeling. And even worse when you take. I only took 250 micrograms of it, but I think that the. If it's VIP or oxytocin, just know this can be okay. I mean, you shouldn't faint or anything. Like, you just need to lay down, drink some water, like you said, take some minerals, and it'll typically go away in a few minutes. I think to a glp, you kind of just have to deal with it. Like, you're just gonna deal with it. I think the CJC question is different because that's not from overdosing. That's just how people respond to it.

[C]

Yes.

[B]

So it doesn't really matter if you took 100 micrograms or 600 micrograms, you're still going to have that response. And so a lot of times, like, some people have to have an EpiPen on hand because of the allergic reaction.

[C]

Yeah.

[B]

That they have to it. And so if you're one of those people, I would say have an EpiPen on hand. I don't think that's going to do anything. If you take too much vip, like, you're just going to have to kind of.

[C]

I mean, could you take Benadryl? Worst case scenario, you could try.

[B]

I don't think it would be harmful.

[C]

Yeah.

[B]

For the vip.

[C]

Yeah.

[B]

For the chc. Yeah, absolutely. Like, if you're having those allergic reactions to it, I think the. The Benadryl would be.

[C]

If you don't have an EpiPen.

[B]

Yeah. If you don't have an EpiPen can be beneficial. But some people do have to end up going to the hospital. That happens more than you think. Where a woman takes cjc. Just seems that women have more mast cell reactions to it. So they take cjc, they have it, and they end up having to go to the hospital. Like, lot of people now are having it with Tess. A lot of people having it now with MOT C too. That's what I always tell people. Start, please start low on the MOT C dose. Cause a lot of people try this like 5 milligrams three times a week thing and it's just too much. I don't know how they do it.

[C]

I don't know how they do it. Even for me like 1 mil.

[B]

But 1 milligram is so strong for me. But anyway, so yeah, there's just not a lot you can do other than try to like expedite the process. Um, I will say ironically that we're talking about this. If you do have those bad side effects from a glp, I've noticed that oxytocin can help with that because it one. It helps like relax the bowels.

[C]

Yeah.

[B]

So I think it speeds up the digestion.

[C]

Especially if you're having like the, the digestion like delay of like.

[B]

Yeah, just like it does sitting there things along. It relaxes the stomach.

[C]

Yeah.

[B]

A little bit. And so I do think you can use that. And it also acts as a little bit of a natural pain reliever. So if you have stomach cramps or pain, it does, does work there. VIP I don't know that it would do as much as oxytocin would in that case. But yeah, unfortunately, to answer that question, it's just one of those things you gotta deal with. I would say just please make sure you're labeling your bottles because I know a lot of people buy kits of peptides that the bottles aren't labeled. We just have a little label maker because that's what we do and just print off the amount and how much water was put into it so you know what you're doing. If you do that, you usually can avoid that.

[C]

And especially if you're taking like, if you're doing a couple at a time, like take one out of the time out of the fridge. Because I've definitely done that where I've had like three sitting on the counter.

[B]

I'm like, wait, you don't know which ones you put?

[C]

I don't know which one I just put. Even though I should know because they're right here in front of me. Like I've definitely done that.

[B]

Yeah, I think that's pretty much. Pretty much that one.

[C]

Yeah.

[B]

Okay, last question. Go back to the young, to the youngins a little bit. The teen acne question. I always have a soft spot for this one because acne to me as a teen was so damaging to my self image because I had severe acne as a child and or A teenager. And it's right in that like phase for me. It was right in that phase for me where you're like trying to like come of age and like find out who you are in the world. And when you have acne, it can be like very hard on your confidence, I think, at any age, but especially at that age. And so I've gotten a few questions about like 17, 18 year old kids dealing with acne. And a lot of parents are giving their kids clo, which can be beneficial. Although in some cases I've actually seen a lot lately of the GHK making the acne worse.

[C]

Yes.

[B]

And what I think is probably happening is, is bringing it to the surface.

[C]

Yes.

[B]

But in doing so is making it worse in a lot of cases. And so I'm not saying GHK is bad for acne, but I do think if you have like cystic acne, it will bring it to a head which can be very painful and can be very like acne that you didn't think was there will come to the surface and then you experience it. And then now the question is like, if you push through that, will that bring it all out? I don't know. But let's just say for whatever reason, CLO, which is BPC, TB500GHK and KPV, is not working for them. They're taking it, they're injecting it and it's not working for them.

[C]

I wouldn't do any of those for acne.

[B]

I actually wouldn't.

[C]

I wouldn't.

[B]

Aside from the kpv.

[C]

The kpv, I wouldn't. I think it could, I think you'd have more benefit doing KPV orally for the gut issues. I would do both. Yeah, I think that would be beneficial. I think in checking it topically can be really beneficial. I think peptide wise, I think LL37 is going to be the best and doing at least an eight week cycle of that is going to be extremely beneficial. Topical ivermectin, horse paste, you'd get to horses, you can use that topically and that works really good. And also like skincare routine, which I know at teens and that age is not, not always easy, but that can also make a big difference. And there's now a lot of laser treatments that you can actually get done there. I wish I knew the top of the head, the laser treatment that I've been doing, but it's a basically no downtime laser treatment. So it's not like a ipl, like you're Burning layers of the skin off. It's just literally killing the bacteria in the skin. So doing that can be very beneficial, especially for the cystic acne, because it will just go in and actually kill what's underneath the dermis. And it's also. There's no downtime. It. Does it. Is it not a little painful sometimes? Yeah, it's kind of like. Kind of like how Terahertz says is that like it actually is. Like, if it is painful in certain spots, it means that there's some type of bacteria there. And I think the, the Lima laser is a Lima. That's an at home, like, laser treatment you can use on your skin. A lot of women use it for anti aging, but it also, because of the lighting in it will also kill any bacteria. That is a. I pretty sure that's a. That's an expensive, expensive laser.

[B]

Notice how Taylor said that? Like, I had any idea what she's. She's supposed to be talking Chinese to me. When it comes to like, skin care products, it's actually flattering to me that anyone thinks I would have any sort of advice on skin care stuff because, like, to me, I'm just like, when I don't know that much about actual skin care technically, like you do because you have like a cosmetology background. But then also the fact that, like, I look like anything more than a caveman to people, but they think like, I would even be qualified to speak on skin care.

[C]

You have good skin now.

[B]

I know, but it's just. I guess that's really for it. But yeah, that's like that, like part of me in the past, if I used to be so ashamed of that to, to. If you would have told me when I was 17 that one day, like, people would ask me for advice on skin care, I would have been like, what? Like, I was so ashamed.

[C]

Pictures of you at 17. And like, I didn't think your acne was that bad. I mean, you had just the way

[B]

I feel like it's just the way I remember.

[C]

I'm sure. And I, I know that like, when I've seen pictures of you, like, like you were so handsome, I would just

[B]

remember waking up and I would have like eight whiteheads.

[C]

Yeah.

[B]

And then like four ones that I know.

[C]

I look, I get it because I had issues.

[B]

I just had acne.

[C]

Just like a couple weeks ago, they

[B]

explode on the mirror, you know, like. And that's just what I remember when I think of, like being a teenager and acne and stuff. And I was on like antibiotics and they made me sick and it made me worse. And I stomach hurt all the time. Like have diarrhea and stuff.

[C]

I do think that Ivermectin horse face is probably like, I wish I would

[B]

have had that, man. That stuff is like for me anytime now that I get like a little breakout. Put that on and it's gone like in a couple days. Like it's crazy how good the Ivermectin horsepace. So to go back to the question instead of talking about myself, Ivermectin horse pace for a kid. Absolutely. Right away. And you can go to Tractor supply. Ace Hardware. Not Ace Hardware, but Tractor supply. If you get off Amazon, you can get off Amazon. So you go on Amazon, type in Ivermectin horse pace. You don't have to have a script.

[C]

Everybody has Tractor supply and I really is out in the country.

[B]

Like tractor supply, like 15 minutes down the road. But. But just go to Amazon. Ivermectin horse paste. Get it and it comes in a tube. You do not use it. You do not ingest it. You just take it out and you use like a little like thumb size amount and apply it to wherever. Like if it's a pimple with a thumb size amount, obviously if it's like a bigger area, you can apply it like over that whole area. It's kind of sticky so you gotta let it dry. It's gonna be like kind of annoying. I like to do it before I go to bed.

[C]

Yeah. I would do it at bedtime. I would not do it in the morning. Morning. I would keep the skin care very light. Yeah.

[B]

Cause it's gonna be oily or.

[C]

Yeah. I will say this too. Like Image Skincare has one of the Clear cell line as one of the best like acne based skincare products I've ever used.

[B]

Yeah.

[C]

And you know, I would definitely put like our kid on that entire line. And there's. They have like a great daytime moisturizer. Because that's the other thing too is that a lot of people don't realize is like not moisturizing can actually cause the acne to be worse. So they think like, you know, putting moisturizer on is going to be bad. It's going to make you more oily. It's just knowing what moisturizer to use

[B]

and when you do it.

[C]

And when you do it you need to moisturize like morning and night. So you know, cleanse, tone. Moisturize is like routine morning and night. And this Clear cell line has a great mattifying daytime. Like lotion for the face. It's not oily. You can wear it underneath makeup. It doesn't like make your makeup oily. It's not going to show up shiny at all if you're a guy.

[B]

So yeah, I would say for a teenager. Ivermectin horsepace first. From there I would do injectable LL37 injectable KPV. I would actually did the KPV from all angles. So I do injectable KPV in the stomach or wherever you do sub Q. You don't really need to inject it near the acne site.

[C]

No.

[B]

Which actually could be more.

[C]

No, I would not.

[B]

Because you just. If you're face or something, you don't want to do that. No, I would do topical kpv. So you can't get topical kpv.

[C]

Now, methylene blue. We didn't talk about topical methyl.

[B]

Topical methylene blue can be really good. So there's like.

[C]

Young Goose has a topical spray.

[B]

Yeah. We should get him on the podcast. I need to reach out to him.

[A]

You do?

[B]

Yeah.

[C]

But he would be that for a while.

[B]

I know. I just need to text him and say it. So topical methylene blue. That stuff works really well. I know it just. But it does topical methylene blue. But. So I would do KPV from all angles. So oral injectable and topal topical KPV and then topical methylene blue. You get that spray from Young Goose. That seems to work really well. You can get like beef tallow methylene blue as well. Yeah, I just don't like how that feels because it's kind of greasy and oily. You definitely want to put that on at night because you don't want to be walking around with that. You'll get real oily and sweaty if you're working out at all. And I would just do those. So that would be like the non clo. I guess that still includes kpb, but the non clo anti acne stack. And I think you will definitely see some benefit from doing all those. Anything else you would add other than like the typical. You said like image Skincare has like a salicylic acid wash that you can use.

[C]

Yeah, that wash. That entire line. The wash, the toner, the moisturizer. They have like an acne spot treatment that would be beneficial. Non embracive. No downtime Laser treatment.

[B]

Yeah.

[C]

Is going to be beneficial. Even if you can do a red light. Red light.

[B]

Getting ideas as we're talking about this.

[C]

I mean, to Be honest. Like, I mean the laser, the laser treatment, the non downtime laser treatment does make a huge.

[B]

Yeah.

[C]

Huge difference. The chemical peels can be great too. You do have to be kind of careful. Like a very like low grade chemical peel. Nothing too abrasive because it can make it worse.

[B]

Yeah.

[C]

The scarring worse. So.

[B]

Yeah.

[C]

Yeah. But that whole line from image, the clear cell line, everything on there.

[A]

Amazing.

[B]

And like my mom used to always tell me I do notice my skin is better at least like if I have acne spots on my back. Getting in the pool, there's something I think in the chlorine. Yeah. Helps like kill if there's bacteria and stuff. But I do notice that, that my skin is clearer when I go in our, our pool. So that's what I would do. Obviously there's lots of different things. Oh, last thing. Cause I meant to say this lorazatide orally because of what that does to help heal the gut environment. I do like oral arasatide. I don't know if it's going to cure acne, but it does help a lot with the gut issues that could then manifest as acne.

[C]

Yeah.

[B]

So good.

[C]

You know, diet wise too. And I know it's hard with teenagers, but you know, diet wise, Dairy.

[B]

Yeah.

[C]

Sugar.

[B]

Vegetable oils.

[C]

Vegetable oils.

[B]

Food. Processed food is not processed food. It's not going to help. And it's really hard at that age.

[C]

It is.

[B]

If you go back to what I was eating as a teenager, it was probably fast food like three or four days a week. Some sort of fast food. Because you're just like. Yeah, just because you're going. And we had off campus lunch and so it's like you go. I would pack my lunch a lot of times, but a lot of times I'd be like, hey, you know. Yeah. And so as a teenager, it's just you're not like, you know, gonna be eating the healthiest. I know I sure wasn't. I didn't even really have the concept of healthy eating as a teenager. I was just like, for me, I was an athlete, so I was like, gotta eat whatever I can to like keep my weight on. And so I didn't think about like how much that played into probably how bad my acne was.

[C]

When I was a teenager in high school, like I would have a V8 for lunch. That was be. My lunch was a V8 McDonald's.

[B]

We drove by the McDonald's the other day and I was like, like I remember going to high school lunch there and getting two McChickens two McDoubles and some French fries. And I've. It's been years. Probably like.

[C]

Yeah.

[B]

15 years since I've been to McDonald's.

[C]

I mean that wasn't healthy that I was drinking a V8 for lunch. I mean there's some other.

[B]

Healthier than what I was eating.

[C]

There's some other issues going on there.

[B]

Yeah, yeah.

[C]

I did not want to eat the cafeteria food cuz I thought it was so disgusting.

[B]

I couldn't eat the cafeteria food. It was so bad. No, it was so bad. Like which luckily we had. I always.

[C]

We didn't have off campus lunch because there was. There was no like restaurants nearby. And then like so many kids got into accidents that they took it away.

[B]

Yeah, well they didn't have it till we could. You could drive. So freshman and sophomore year.

[C]

Yeah.

[B]

No, and I packed my lunch most of the time my freshman sophomore year.

[C]

Yeah.

[B]

Like if I had to for whatever reason I'd eat the cafeteria food and it was so nasty. But almost always I was packing like a sandwich or something.

[A]

Yeah.

[B]

But then when you had off campus, you know, it was like go wherever and I packed my lunch sometimes but a lot of times it'd be like eat fast food and then just do it back. So yeah, I feel for the teenagers and I'm always, always going to help them whatever I can. So anyway, that is all the questions. So thank you guys for tuning in as always. I'll always make sure if you. On all my properties or destinations now there's a link and it's one link and it has everything on there and so you can just click on that link and then you'll see a way to submit a question to me. And so I add all of those to my document I have and then I aggregate these and then kind of make these little things that we do and I use those for the solo Q&As which I will continue to do as well. Then obviously two coffee talks. Feel free to always come on the coffee talks and we'll do the rapid fire Q and A there. But anything in closing. I thought it was a good, good one today. Yeah, it was a good one. Nice little assortment of topics. Anything you want to leave the viewers with?

[C]

No, no, sorry for. We got very chatty today.

[B]

So I think it's a good thing. I think people as much as sometimes I don't know why they think they like listening to give them context for understanding.

[C]

Yeah.

[B]

Like what we're talking about. So as always, thank you guys. Without you guys we don't exist. So whatever shape, form or fashion is that you support us. Thank you so much. It goes so far in helping us bring these messages to you and to give you the content. And my goal with content is always to get as much out there. So obviously, if you want access to us, you can join the private group. And that's where we do live coaching calls, where you can come on live and ask us questions with your video on and everything. And also, too, you can private message us and get all of your messages responded to if you have questions. I know a lot of people just are like, hey, I've got these questions I want to ask you. I want to make sure I get to talk to you. That is the best place to do so. So we've actually got like 240 people in the private group now, so there's a lot of other amazing people and health coaches and everything that you can talk to in there if you have questions. So that's it for this one. We'll go ahead and shut it down. We'll see you in the next one. And thank you guys again so much and we'll talk to you soon.

[C]

Thanks, guys.