Chronic pain affects an enormous portion of the population and for decades, the default answers have been drugs, sedation, or invasive procedures. In this Energy Code Deep Dive, Dr. Mike Belkowski and Don Bailey unpack a 2026 systematic review (Ferreira et al.) that analyzed 14 randomized controlled trials on photobiomodulation (PBM) for chronic pain conditions, including fibromyalgia, neuropathy, TMJ/TMD, and post-COVID pain.

They break down the “energy code” behind PBM: how red and near-infrared light can stimulate mitochondria to produce more ATP, lower inflammatory cytokines (like IL-1β, IL-6, and TNF-α), and modulate pain signaling in both peripheral nerves and the central nervous system. The episode also covers why PBM is not “just shining a flashlight,” why dosing and wavelength precision matter, and why this field may represent a shift from the chemical age of medicineto the energy age.

Most importantly, they discuss the clinical implications: meaningful symptom relief, improved function and quality of life, and a remarkably strong safety profile—with 13 of 14 trials reporting zero adverse events.

(Educational content only, not medical advice.)

Article Discussed in Episode:

Photobiomodulation in chronic pain: a systematic review of randomized clinical trials

Key Quotes From Dr. Mike:

“What if the answer (to chronic pain) wasn’t chemical at all? What if the answer was actually energetic?”

“You’re making the world less hostile to their bodies.” (re: fibromyalgia pain threshold)

“We’re talking about repairing the wiring, not just muting the signal.”

“PBM doesn’t just numb the pain… it is returning the tissue to a functional state.”

“We are moving from the chemical age to the energy age.”

Key points

Chronic pain is a massive global problem

The episode frames chronic pain as a major public health crisis, affecting a huge percentage of adults worldwide.
PBM is not “flashlight therapy”

This is a precise medical/biological intervention using specific wavelengths and dosing parameters—not generic red light.
The episode centers on a 2026 systematic review

Ferreira et al. analyzed 14 randomized controlled trials (2015–2025), making this one of the strongest summaries of recent PBM pain research.
PBM works through a 3-pronged mechanism
- Mitochondrial boost (more ATP / “recharging the battery”)
- Inflammation reduction (lower IL-1β, IL-6, TNF-α, prostaglandins)
- Neural modulation (reduced pain fiber excitability + neurotransmitter shifts)
Wavelength and power density are everything

The biological “key” usually falls in the 660–905 nm range, with correct irradiance needed to trigger a mitochondrial response.
Fibromyalgia results were especially encouraging

The review highlighted rigorous trials (including triple-blinded designs) showing reduced tender points, lower pain, and improved pain threshold.
Whole-body PBM may improve quality of life

In addition to symptom reduction, some studies showed improvements in health-related quality of life, which matters deeply in chronic pain.
Neuropathy outcomes were clinically meaningful
- Chemotherapy-induced neuropathy: notable response rates and reduced neuropathy scores
- Diabetic neuropathy: significant pain reductions using LED-based protocols
PBM may help post-COVID pain syndromes

The review included data on post-COVID orofacial pain and tension headaches, with reductions in pain scores and improvements in sleep/enjoyment of life.
TMJ/TMD results suggest PBM is best as part of a plan

PBM helped in some studies, but manual therapy sometimes performed similarly—supporting a multi-modalapproach.
Safety is one of PBM’s strongest advantages

13 out of 14 trials reported zero adverse events; the only noted effects were mild/transient warmth or tingling.
The big limitation: protocol heterogeneity

Different wavelengths, doses, and treatment durations make standardization difficult—this is the “wild west” problem.
PBM may restore function, not just reduce pain

The review found improvements in walking, working ability, sleep, and daily functioning—not just lower pain scores.
The larger theme: a shift to energy medicine

The episode closes on the idea that medicine may be moving from a “chemical age” to an “energy age.”

Episode timeline

0:19–1:28 — Intro: chronic pain as a global crisis

Don and Dr. Mike frame the scale of chronic pain and introduce the central question: can light treat pain?

1:28–2:40 — The review they’re unpacking (Ferreira, 2026)

Overview of the systematic review in Frontiers in Integrative Neuroscience and its 14 RCTs.

2:40–3:34 — Skeptic question: “Is this just a flashlight?”

They address the common misconception and define PBM as a real scientific modality.

3:34–6:59 — How PBM works: the 3-pronged mechanism

Mitochondrial ATP boost
Inflammation reduction
Neural modulation

Includes why 660–905 nm and irradiance matter.

7:00–9:16 — Fibromyalgia: one of the toughest pain conditions

Discussion of key fibromyalgia studies, including a triple-blinded RCT and whole-body PBM results.

9:16–11:25 — Neuropathy: chemo-induced and diabetic nerve pain

Evidence for PBM helping neuropathy symptoms and possibly supporting nerve repair/myelin health.

11:26–12:27 — Post-COVID pain and headaches

Review of 2024 post-COVID orofacial pain/tension headache study; sleep and quality-of-life improvements noted.

12:27–13:44 — TMJ/TMD: nuanced but promising

PBM helps, but manual therapy also matters; best used as part of a multi-modal strategy.

13:44–15:19 — Safety profile: the standout strength

13/14 studies reported zero adverse events; only mild temporary warmth/tingling in one trial.

15:19–17:10 — The “wild west” problem: protocol heterogeneity

Different wavelengths, doses, and treatment lengths make standardization challenging, but also explain variable outcomes.

17:10–18:23 — Function over pain scores

PBM improves more than pain intensity—sleep, work, walking, and daily function improve too.

18:23–19:42 — Big-picture summary

Ferreira review supports PBM as a safe, promising, effective chronic pain tool with real biological effects.

19:42–20:40 — Closing thought: from chemical medicine to energy medicine

Dr. Mike’s thesis on the “energy age” and what standardized PBM could mean for the future of chronic pain care.

20:40–21:28 — Outro / call to action

Encouragement to explore the research and consider light-based options for pain.

Dr. Mike's #1 recommendations:

Deuterium depleted water: Litewater (code: DRMIKE)

EMF-mitigating products: Somavedic (code: BIOLIGHT)

Blue light blocking glasses: Ra Optics (code: BIOLIGHT)

Grounding products: Earthing.com

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